V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

NAP1L5 Gene

protein-coding GIFtS: 49

GC04M089836

nucleosome assembly protein 1-like 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
1110020M21Rik ^²
DRLM ^¹, ², ⁵
OTTHUMP00000161563 ^²

Descriptions
down-regulated in liver malignancy ^²
nucleosome assembly protein 1-like 5 ^²

External Ids
HGNC: 19968¹
Entrez Gene: 266812²
UniProtKB: Q96NT1³
Ensembl: ENSG00000177432⁷

Search outside databases for aliases for NAP1L5 gene

Previous GC identifers: GC04M090075 GC04M089974

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAP1L5 gene

Entrez Gene cytogenetic band: 4q22.1|4q21-q22 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q21-q22

NAP1L5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M089836: (about GC identifiers)

Start:	89,836,089 bp from pter
End:	89,838,409 bp from pter
Size:	2,321 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NP1L5_HUMAN, Q96NT1 (See protein sequence)

Recommended Name: Nucleosome assembly protein 1-like 5

Size: 182 amino acids; 19593 Da

Subcellular location: Nucleus (Potential)

REFSEQ proteins: NP_715638.1

ENSEMBL proteins:

ENSP00000320488

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (NAP1L5)

OriGene Purified Recombinant Human Protein: NAP1L5

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for NAP1L5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (NAP1L5)
	Novus Biologicals Antibody for NAP1L5

Assays for NAP1L5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96NT1

ProtoNet protein and cluster: Q96NT1

UniProtKB/Swiss-Prot: NP1L5_HUMAN, Q96NT1

Similarity: Belongs to the nucleosome assembly protein (NAP) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAP1L5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153757

Applied Biosystems Silencer® siRNAs for NAP1L5

Sigma-Aldrich siRNA for NAP1L5

Sigma-Aldrich shRNA for NAP1L5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAP1L5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_153757
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153757
untagged cDNA clones in CMV expression vector (see all 2): AK054689

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_153757

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Interacting proteins for NAP1L5 (ENSP00000320488³ Q96NT1^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DFFA	O00273¹	EBI-713627, EBI-727171
HAP1	P54257²	MINT-65240
KAT5	Q92993²	MINT-65241
KIAA1377	Q9P2H0²	MINT-65243
LUC7L2	Q9Y383²	MINT-65244

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAP1L5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAP1L5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153757

Sigma-Aldrich siRNA for NAP1L5

Sigma-Aldrich shRNA for NAP1L5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_153757

REFSEQ mRNAs for NAP1L5 gene:

NM_153757.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_153757

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153757
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153757
                                 untagged cDNA clones in CMV expression vector (see all 2): AK054689

Additional cDNA sequence:

AK054689.1 AL834329.1 BC022544.1 BC039416.1 BC104883.1 CR591413.1

5 DOTS entries:

DT.214207 DT.428686 DT.100774043 DT.121250597 DT.100722910

24/88 AceView cDNA sequences (see all 88 ):

BQ771809 AI246169 AI431867 BQ010322 AI816263 CA393605 AI364276 N21977

AI090144 AI040731 AI816344 F10839 Z38846 CR591413 AW161560 CB047189

Z42684 AA772367 AA954245 AA838733 BE551425 BC039416 NM_153757 BE892485

highest scoring ESTs for NAP1L5:

AK054689 AL834329 AW025330 BC022544 BM310266 BM876144 BQ639280 CA393605 CA394609 CB047190

Unigene Cluster for NAP1L5:

Nucleosome assembly protein 1-like 5

Hs.12554 [show with all ESTs]

Unigene Representative Sequence: NM_153757

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000323061

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAP1L5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAP1L5

¹ / ² / ³

5 probe-sets matching NAP1L5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53761_at²^{, 3}	U95-B	2	1.00	0.97	1.00	1.00	AW025330	0.80	1.00	0.91	1
228063_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW025330	0.80	1.00	0.91	1
228062_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW025330	0.80	1.00	0.91	1
228063_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228062_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAP1L5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGCTTTTAG

SOURCE GeneReport for Unigene cluster: Hs.12554

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAP1L5 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAP1L5¹	--	nucleosome assembly protein 1-like 5	89.73(n) 89.53(a)	607931 XM_845030.1 XP_850123.1
chimpanzee (Pan troglodytes)	NAP1L5¹	--	nucleosome assembly protein 1-like 5	98.53(n) 96.15(a)	742154 XM_001160970.1 XP_001160970.1
cow (Bos taurus)	NAP1L5¹	--	nucleosome assembly protein 1-like 5	87.36(n) 85.71(a)	508508 XM_001249425.1 XP_001249426.1
rat (Rattus norvegicus)	Nap1l5¹	--	nucleosome assembly protein 1-like 5	78.06(n) 82.58(a)	688843 XM_001063370.1 XP_001063370.1
mouse (Mus musculus)	Nap1l5^{1, 5}	6⁵	nucleosome assembly protein 1-like 5^{1, 5}	80.22(n)¹ 84(a)¹	58243¹ NM_021432.1¹ NP_067407.1¹ AB041556⁵ AK003875⁵ (see all 9)

About this table Species with no ortholog for NAP1L5

ENSEMBL Gene Tree for NAP1L5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NAP1L5 gene

NAP1L6² NAP1L3² NAP1L2² NAP1L4² NAP1L1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612203

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for NAP1L5 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. (PubMed id 12383514)^{2, 3} Harada H....Emi M. (2002)
A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. (PubMed id 17291163)³ Wood A.J....Oakey R.J. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 266812	HGNC: 19968	AceView: NAP1L5	Ensembl:ENSG00000177432	euGenes: HUgn266812
ECgene: NAP1L5	H-InvDB: NAP1L5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NAP1L5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NAP1L5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAP1L5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAP1L5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAP1L5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAP1L5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAP1L5)
	Antibodies (NAP1L5)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NAP1L5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NAP1L5

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NAP1L5 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

NAP1L5 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for NAP1L5

Summaries
for NAP1L5

Genomic Location
for NAP1L5

Proteins
for NAP1L5

Protein Domains/
Families
for NAP1L5

Gene Function
for NAP1L5

Pathways & Interactions
for NAP1L5

Drugs & Compounds
for NAP1L5

Transcripts
for NAP1L5

Expression
for NAP1L5

Orthologs
for NAP1L5

Paralogs
for NAP1L5

SNPs/Variants
for NAP1L5

Disorders & Mutations
for NAP1L5

Medical News
for NAP1L5

Publications
for NAP1L5

Search for NAP1L5

Genome Databases showing NAP1L5

Other Databases showing NAP1L5

Specialized Databases showing NAP1L5

Licensable Technologies
for NAP1L5

Services
for NAP1L5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAP1L5 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor NAP1L5

Summariesfor NAP1L5

Genomic Locationfor NAP1L5

Proteinsfor NAP1L5

Protein Domains/Familiesfor NAP1L5

Gene Functionfor NAP1L5

Pathways & Interactionsfor NAP1L5

Drugs & Compoundsfor NAP1L5

Transcriptsfor NAP1L5

Expression for NAP1L5

Orthologsfor NAP1L5

Paralogsfor NAP1L5

SNPs/Variantsfor NAP1L5

Disorders & Mutationsfor NAP1L5

Medical Newsfor NAP1L5

Publicationsfor NAP1L5

Search for NAP1L5

Genome Databases showing NAP1L5

Other Databases showing NAP1L5

Specialized Databases showing NAP1L5

Licensable Technologiesfor NAP1L5

Servicesfor NAP1L5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAP1L5

Summaries
for NAP1L5

Genomic Location
for NAP1L5

Proteins
for NAP1L5

Protein Domains/
Families
for NAP1L5

Gene Function
for NAP1L5

Pathways & Interactions
for NAP1L5

Drugs & Compounds
for NAP1L5

Transcripts
for NAP1L5

Expression
for NAP1L5

Orthologs
for NAP1L5

Paralogs
for NAP1L5

SNPs/Variants
for NAP1L5

Disorders & Mutations
for NAP1L5

Medical News
for NAP1L5

Publications
for NAP1L5

Licensable Technologies
for NAP1L5

Services
for NAP1L5