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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAP1L5 Gene

protein-coding   GIFtS: 47
GCID: GC04M089617

nucleosome assembly protein 1-like 5

 Explore 2 diseases affiliated with
NAP1L5 via our new
 Human Malady Compendium 
Biological research products
for NAP1L5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nucleosome Assembly Protein 1-Like 51 2
DRLM1 2 3 5
Down-Regulated In Liver Malignancy2 3

External Ids:    HGNC: 199681   Entrez Gene: 2668122   Ensembl: ENSG000001774327   OMIM: 6122035   UniProtKB: Q96NT13   

Export aliases for NAP1L5 gene to outside databases

Previous GC identifers: GC04M090075 GC04M089974 GC04M089836 GC04M085368


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAP1L5 gene promoter:
         c-Fos   TBP   AP-1   JunB   FosB   Fra-1   Lmo2   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAP1L5 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAP1L5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAP1L5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1|4q21-q22   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21-q22

NAP1L5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAP1L5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M089617:  view genomic region     (about GC identifiers)

Start:
89,617,066 bp from pter      End:
89,619,386 bp from pter
Size:
2,321 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NP1L5_HUMAN, Q96NT1 (See protein sequence)
Recommended Name: Nucleosome assembly protein 1-like 5  
Size: 182 amino acids; 19593 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for NAP1L5: NX_Q96NT1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96NT1

  • NAP1L5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_715638.1  
    ENSEMBL proteins: 
     ENSP00000320488  

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    Uscn Proteins for NAP1L5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NAP1L5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NAP1L5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q96NT1

    ProtoNet protein and cluster: Q96NT1

    UniProtKB/Swiss-Prot: NP1L5_HUMAN, Q96NT1
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-21* hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-449a hsa-miR-502-3p hsa-miR-570
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAP1L5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for NAP1L5 (Q96NT12, 3 ENSP000003204884) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-65244 I2D: score=5 
    LUC7L2Q9Y3832, 3MINT-65244 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-65243 I2D: score=5 
    MAGEH1Q9H2132, 3MINT-65242 I2D: score=5 
    PTNP212462, 3MINT-65239 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--


    NAP1L5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAP1L5
    Search CenterWatch for drugs/clinical trials and news about NAP1L5 / NP1L5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAP1L5 gene: 
    NM_153757.2  

    Unigene Cluster for NAP1L5:

    Nucleosome assembly protein 1-like 5
    Hs.12554  [show with all ESTs]
    Unigene Representative Sequence: NM_153757
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000323061(uc003hrx.3)

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    hsa-miR-21* hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-miR-449a hsa-miR-502-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNAP1L5 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK054689.1 AL834329.1 BC022544.1 BC039416.1 BC104883.1 

    5 DOTS entries:

    DT.214207  DT.428686  DT.100774043  DT.121250597  DT.100722910 

    24/88 AceView cDNA sequences (see all 88):

    BQ771809 AI090144 CB047189 F10839 AA954245 AI816344 Z38846 AI431867 
    AA838733 Z42684 BQ010322 N21977 AI040731 AI246169 AI816263 CR591413 
    AA772367 AW161560 AI364276 CA393605 CK300824 AI744533 BE503105 BX452219 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAP1L5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCTTTTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NAP1L5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    BoneZeugopod Epiphyseal EndBone
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature follicles (In-vitro growth and ...)

    See NAP1L5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAP1L5

    SOURCE GeneReport for Unigene cluster: Hs.12554

    UniProtKB/Swiss-Prot: NP1L5_HUMAN, Q96NT1
    Tissue specificity: Predominantly expressed in brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAP1L5 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nap1l51 , 5 nucleosome assembly protein 1-like 51, 5 80(n)1
    84(a)1
      6 (27.90 cM)5
    582431  NM_021432.21  NP_067407.11 
     589052345 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nap16
    CG50176
    (see all 3)
    --
    8(a)
    7(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(19792698-19794837)
    3R(23738169-23739507)
    worm
    (Caenorhabditis elegans)
    Secernentea nap-16
    Protein NAP-1
    10(a)
    1 → many
    IV(8377692-8379308)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NAP1;36
    NFA26
    (see all 4)
    nucleosome assembly protein 1;2
    (see all 4)
    8(a)
    8(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    5(23032449-23035661)
    2(8438393-8441384)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 5)
    NAP domain containing protein, putative, expressed...
    NAP domain containing protein, putative, expressed...
    (see all 5)
    9(a)
    9(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    5(26745360-26749888)
    6(2557016-2561243)


    ENSEMBL Gene Tree for NAP1L5 (if available)
    TreeFam Gene Tree for NAP1L5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAP1L5 gene
    NAP1L32  NAP1L62  NAP1L22  NAP1L42  NAP1L12  
    5 SIMAP similar genes for NAP1L5 using alignment to 1 protein entry:     NP1L5_HUMAN:
    DKFZp434K0835    NAP1L4    NAP1L4b    NAP1L3    NAP1L2

    NAP1L5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAP1L5
    PGOHUM00000238271


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAP1L5
    DNA2.0 Custom Variant and Variant Library Synthesis for NAP1L5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NAP1L5 for disorders           About GeneDecksing

    OMIM gene information: 612203    OMIM disorders: --

    2 diseases for NAP1L5:    About MalaCards
    obesity    malaria

    Human Genome Epidemiology (HuGE) Navigator: NAP1L5 (1 document)

    Export disorders for NAP1L5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAP1L5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with NAP1L5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. (PubMed id 12383514)1, 2, 3 Harada H....Emi M. (2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    4. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    5. Large copy-number variations are enriched in cases wi th moderate to extreme obesity. (PubMed id 20622171)1 Wang K....Price R.A. (2010)
    6. Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
    7. A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. (PubMed id 17291163)1 Wood A.J....Oakey R.J. (2007)
    8. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 266812 HGNC: 19968 AceView: NAP1L5 Ensembl:ENSG00000177432 euGenes: HUgn266812
    ECgene: NAP1L5 H-InvDB: NAP1L5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAP1L5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAP1L5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAP1L5 gene:
    Search GeneIP for patents involving NAP1L5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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