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Aliases for NAP1L5 Gene

Aliases for NAP1L5 Gene

  • Nucleosome Assembly Protein 1 Like 5 2 3
  • Nucleosome Assembly Protein 1-Like 5 2 5
  • Down-Regulated In Liver Malignancy 3 4
  • DRLM 3 4

External Ids for NAP1L5 Gene

Previous GeneCards Identifiers for NAP1L5 Gene

  • GC04M090075
  • GC04M089974
  • GC04M089836
  • GC04M089617
  • GC04M085368

Summaries for NAP1L5 Gene

Entrez Gene Summary for NAP1L5 Gene

  • This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. [provided by RefSeq, Nov 2015]

GeneCards Summary for NAP1L5 Gene

NAP1L5 (Nucleosome Assembly Protein 1 Like 5) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L5 Gene

Genomics for NAP1L5 Gene

Regulatory Elements for NAP1L5 Gene

Promoters for NAP1L5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAP1L5 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAP1L5 Gene

Chromosome:
4
Start:
88,695,915 bp from pter
End:
88,698,235 bp from pter
Size:
2,321 bases
Orientation:
Minus strand

Genomic View for NAP1L5 Gene

Genes around NAP1L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L5 Gene

Proteins for NAP1L5 Gene

  • Protein details for NAP1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NT1-NP1L5_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 5
    Protein Accession:
    Q96NT1

    Protein attributes for NAP1L5 Gene

    Size:
    182 amino acids
    Molecular mass:
    19593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAP1L5 Gene

Proteomics data for NAP1L5 Gene at MOPED

Post-translational modifications for NAP1L5 Gene

  • Ubiquitination at Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L5 Gene

Domains & Families for NAP1L5 Gene

Protein Domains for NAP1L5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAP1L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NT1

UniProtKB/Swiss-Prot:

NP1L5_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L5: view

No data available for Gene Families for NAP1L5 Gene

Function for NAP1L5 Gene

genes like me logo Genes that share phenotypes with NAP1L5: view

Animal Model Products

miRNA for NAP1L5 Gene

miRTarBase miRNAs that target NAP1L5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L5 Gene

Localization for NAP1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAP1L5 Gene COMPARTMENTS Subcellular localization image for NAP1L5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NAP1L5 Gene

Pathways & Interactions for NAP1L5 Gene

SuperPathways for NAP1L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAP1L5 Gene

Drugs & Compounds for NAP1L5 Gene

No Compound Related Data Available

Transcripts for NAP1L5 Gene

mRNA/cDNA for NAP1L5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(88) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L5 Gene

Nucleosome assembly protein 1-like 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L5 Gene

No ASD Table

Relevant External Links for NAP1L5 Gene

GeneLoc Exon Structure for
NAP1L5
ECgene alternative splicing isoforms for
NAP1L5

Expression for NAP1L5 Gene

mRNA expression in normal human tissues for NAP1L5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L5 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.3), Brain - Frontal Cortex (BA9) (x5.6), and Brain - Anterior cingulate cortex (BA24) (x5.6).

Protein differential expression in normal tissues from HIPED for NAP1L5 Gene

This gene is overexpressed in Frontal cortex (17.1), Retina (13.0), Spinal cord (8.9), Fetal Brain (7.9), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAP1L5 Gene



SOURCE GeneReport for Unigene cluster for NAP1L5 Gene Hs.12554

mRNA Expression by UniProt/SwissProt for NAP1L5 Gene

Q96NT1-NP1L5_HUMAN
Tissue specificity: Predominantly expressed in brain.
genes like me logo Genes that share expression patterns with NAP1L5: view

Protein tissue co-expression partners for NAP1L5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NAP1L5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NAP1L5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAP1L5 35
  • 89.05 (n)
  • 91.04 (a)
NAP1L5 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAP1L5 35
  • 89.52 (n)
  • 91.13 (a)
NAP1L5 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nap1l5 35
  • 79.34 (n)
  • 84.3 (a)
Nap1l5 16
Nap1l5 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAP1L5 35
  • 98.35 (n)
  • 96.15 (a)
NAP1L5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nap1l5 35
  • 78.79 (n)
  • 84.3 (a)
Species with no ortholog for NAP1L5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NAP1L5 Gene

ENSEMBL:
Gene Tree for NAP1L5 (if available)
TreeFam:
Gene Tree for NAP1L5 (if available)

Paralogs for NAP1L5 Gene

(4) SIMAP similar genes for NAP1L5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NAP1L5 Gene

genes like me logo Genes that share paralogs with NAP1L5: view

No data available for Paralogs for NAP1L5 Gene

Variants for NAP1L5 Gene

Sequence variations from dbSNP and Humsavar for NAP1L5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_050227 -

Structural Variations from Database of Genomic Variants (DGV) for NAP1L5 Gene

Variant ID Type Subtype PubMed ID
nsv461576 CNV Gain 19166990

Variation tolerance for NAP1L5 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAP1L5 Gene

HapMap Linkage Disequilibrium report
NAP1L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L5 Gene

Disorders for NAP1L5 Gene

Relevant External Links for NAP1L5

Genetic Association Database (GAD)
NAP1L5
Human Genome Epidemiology (HuGE) Navigator
NAP1L5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAP1L5

No disorders were found for NAP1L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAP1L5 Gene

Publications for NAP1L5 Gene

  1. Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. (PMID: 12383514) Harada H. … Emi M. (Gene 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  4. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  5. A case-by-case evolutionary analysis of four imprinted retrogenes. (PMID: 21166792) McCole R.B. … Oakey R.J. (Evolution 2011) 3

Products for NAP1L5 Gene

Sources for NAP1L5 Gene

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