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NAP1L4 Gene

protein-coding   GIFtS: 55
GCID: GC11M002965

Nucleosome Assembly Protein 1-Like 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nucleosome Assembly Protein 1-Like 41 2     NAP2L2 5
NAP22 3 5     NAP1L4b2
Nucleosome Assembly Protein 22 3     hNAP22
NAP-22 3     Nucleosome Assembly Protein 1-Like 4b2

External Ids:    HGNC: 76401   Entrez Gene: 46762   Ensembl: ENSG000002055317   OMIM: 6016515   UniProtKB: Q997333   
ORGUL members:         

Export aliases for NAP1L4 gene to outside databases

Previous GC identifers: GC11M003025 GC11M003216 GC11M002924 GC11M002929 GC11M002919 GC11M002922 GC11M002754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAP1L4 Gene:
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and
linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This
gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene
region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor,
rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAP1L4 Gene:
NAP1L4 (nucleosome assembly protein 1-like 4) is a protein-coding gene. Diseases associated with NAP1L4 include adrenocortical carcinoma, and beckwith-wiedemann syndrome. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is NAP1L3.

Gene Wiki entry for NAP1L4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NAP1L4 gene promoter:
         NF-YA   CBF-C   C/EBPalpha   CHOP-10   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAP1L4 promoter sequence
   Search Chromatin IP Primers for NAP1L4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAP1L4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

NAP1L4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAP1L4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002965:  view genomic region     (about GC identifiers)

Start:
2,965,660 bp from pter      End:
3,013,607 bp from pter
Size:
47,948 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NP1L4_HUMAN, Q99733 (See protein sequence)
Recommended Name: Nucleosome assembly protein 1-like 4  
Size: 375 amino acids; 42823 Da
Secondary accessions: B2R6J4 F5HFY4
Alternative splicing: 2 isoforms:  Q99733-1   Q99733-2   

Explore the universe of human proteins at neXtProt for NAP1L4: NX_Q99733

Explore proteomics data for NAP1L4 at MOPED

Post-translational modifications: 

  • Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in
    polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated
    due to the absence of functional TTLL10 in human (By similarity)1
  • Ubiquitination2 at Lys26, Lys71, Lys94, Lys105, Lys146, Lys282
  • Modification sites at PhosphoSitePlus

  • See NAP1L4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005960.1  
    ENSEMBL proteins: 
     ENSP00000369915   ENSP00000436397   ENSP00000431644   ENSP00000436488   ENSP00000387783  
     ENSP00000382523   ENSP00000405912   ENSP00000435327   ENSP00000434759   ENSP00000432126  
     ENSP00000431799   ENSP00000437130   ENSP00000412048   ENSP00000433512  

    NAP1L4 Human Recombinant Protein Products:

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    NAP1L4 Antibody Products:

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    ThermoFisher Antibodies for NAP1L4
    Search LSBio for Antibodies for NAP1L4

    NAP1L4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for NAP1L4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q99733

    ProtoNet protein and cluster: Q99733

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: NP1L4_HUMAN, Q99733
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    NAP1L4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for NAP1L4:
    nucleosome assembly protein 1-like 4, excluded of the imprinting domain,interacting with core and linker
    histones,putative chaperone

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding TAS9325046
         
    NAP1L4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAP1L4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAP1L4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAP1L4

    miRNA
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    miRTarBase miRNAs that target NAP1L4:
    hsa-mir-196a-5p (MIRT048253)

    Block miRNA regulation of human, mouse, rat NAP1L4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAP1L4 (see all 19):
    hsa-miR-26a-2* hsa-miR-520d-5p hsa-miR-570 hsa-miR-633 hsa-miR-4325 hsa-miR-33b hsa-miR-3148 hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidNAP1L4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAP1L4
    Predesigned siRNA for gene silencing in human, mouse, rat NAP1L4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NAP1L4

    Clone
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    OriGene clones in human, mouse for NAP1L4 (see all 6)
    OriGene ORF clones in mouse, rat for NAP1L4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAP1L4 (NM_005969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAP1L4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAP1L4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NP1L4_HUMAN, Q99733: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9325046

    NAP1L4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAP1L4
    Interactions:

        Search GeneGlobe Interaction Network for NAP1L4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAP1L4 (Q997331, 3 ENSP000003699154) via UniProtKB, MINT, STRING, and/or I2D (see all 322)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=7 STRING: ENSP00000352980
    HIST2H4AP628053, ENSP000003581624I2D: score=7 STRING: ENSP00000358162
    HIST1H4FP628053, ENSP000003669744I2D: score=7 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=7 STRING: ENSP00000289352
    HIST1H4BP628053I2D: score=7 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    NAP1L4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAP1L4 (NP1L4)

    2 Novoseek inferred chemical compound relationships for NAP1L4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nap-2 94.3 3 9268640 (1), 9618174 (1)
    heparin 23 2 10764593 (1), 15368365 (1)



    NAP1L4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAP1L4 gene: 
    NM_005969.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000380542(uc001lxc.3 uc010qxm.2 uc010qxn.2) ENST00000469805(uc001lxb.3)
    ENST00000469089 ENST00000526115 ENST00000492594 ENST00000526023 ENST00000492685
    ENST00000528363 ENST00000483643 ENST00000528261 ENST00000532325 ENST00000448187
    ENST00000399614 ENST00000430811 ENST00000529361 ENST00000528968 ENST00000530064
    ENST00000526842
    miRNA
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    Block miRNA regulation of human, mouse, rat NAP1L4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAP1L4 (see all 19):
    hsa-miR-26a-2* hsa-miR-520d-5p hsa-miR-570 hsa-miR-633 hsa-miR-4325 hsa-miR-33b hsa-miR-3148 hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidNAP1L4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAP1L4
    Predesigned siRNA for gene silencing in human, mouse, rat NAP1L4
    Clone
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    OriGene clones in human, mouse for NAP1L4 (see all 6)
    OriGene ORF clones in mouse, rat for NAP1L4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAP1L4 (NM_005969)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAP1L4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAP1L4
    Primer
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    OriGene qPCR primer pairs and template standards for NAP1L4
    OriGene qSTAR qPCR primer pairs in human, mouse for NAP1L4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAP1L4
      QuantiTect SYBR Green Assays in human, mouse, rat NAP1L4
      QuantiFast Probe-based Assays in human, mouse, rat NAP1L4

    Selected AceView cDNA sequences (see all 569):

    AA448113 BF525447 BU553082 AA746108 AI635549 BM907438 AI798720 BX644512 
    AA573896 BM927507 BQ027034 AW274745 BQ272153 BP367651 BE673238 H92201 
    BI521360 BU839442 BP338684 AA356087 BM458422 BM695399 AI658844 AA324587 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAP1L4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCAGGCGC
    NAP1L4 Expression
    About this image

    NAP1L4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAP1L4 Protein Expression

    UniProtKB/Swiss-Prot: NP1L4_HUMAN, Q99733
    Tissue specificity: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis

        Custom PCR Arrays for NAP1L4
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    QuantiFast Probe-based Assays in human, mouse, rat NAP1L4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAP1L4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nap1l41 , 5 nucleosome assembly protein 1-like 41, 5 85.74(n)1
    94.8(a)1
      7 (88.24 cM)5
    179551  NM_001285489.11  NP_001272418.11 
     1435135795 
    chicken
    (Gallus gallus)
    Aves NAP1L41 nucleosome assembly protein 1-like 4 83.14(n)
    88.37(a)
      423087  NM_001006469.2  NP_001006469.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAP1L46
    nucleosome assembly protein 1-like 4
    87(a)
    1 ↔ 1
    1(68646490-68699662)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nap1l41 nucleosome assembly protein 1-like 4 74.14(n)
    80(a)
      780369  NM_001079439.1  NP_001072907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nap1l4b1 nucleosome assembly protein 1-like 4b 71.7(n)
    73.58(a)
      492812  NM_001007453.1  NP_001007454.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nap13 nucleosome assembly histone-specific
    chaperone
    51(a)
    (best of 2)
      60A9   --
    worm
    (Caenorhabditis elegans)
    Secernentea D2096.83
    nap-11
    nap-11 37(a)3
    51.78(n)1
    42.96(a)1
      IV(8378271-8379497)3
    1776361  NM_069021.61  NP_501422.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAP1(YKR048C)4 Protein that interacts with mitotic cyclin Clb2p; required more   --   11(526640-525387) 853922  NP_012974.1 


    ENSEMBL Gene Tree for NAP1L4 (if available)
    TreeFam Gene Tree for NAP1L4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAP1L4 gene
    NAP1L32  NAP1L62  NAP1L22  NAP1L12  
    5 SIMAP similar genes for NAP1L4 using alignment to 14 protein entries:     NP1L4_HUMAN (see all proteins):
    NAP1L1    NAP1L6    NAP1L2    DKFZp434K0835    NAP1L5

    NAP1L4 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NAP1L4
    PGOHUM00000244155 PGOHUM00000241492 PGOHUM00000241522


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAP1L4 (see all 1088)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs587553331,2
    C--2796158(+) AGAAA-/AAGAAA
            
    GGAAA
    1 -- int11Minor allele frequency- AAGAAA:0.00NA 2
    rs740504421,2
    C,F--2965191(+) ACAGCG/ATTTCA 1 -- ds50012Minor allele frequency- A:0.08WA 120
    rs122861201,2
    C,F,A--2965252(+) GTGCCG/TGTGCA 1 -- ds500111Minor allele frequency- T:0.12NA WA CSA EA 371
    rs1845906091,2
    --2965275(+) TGCCTC/TCTCTC 1 -- ds50010--------
    rs1876493161,2
    --2965313(+) AGCTTC/TAGAGA 1 -- ds50010--------
    rs1438534251,2
    --2965422(+) CCTGGC/GGGCAG 1 -- ds50010--------
    rs1925593591,2
    --2965449(+) GGCCCC/GCAGTG 1 -- ds50010--------
    rs10505541,2
    --2965705(-) GTACAG/TAATAG 1 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs106701,2
    C,F--2965728(+) CTGTAT/ATCAGT 1 -- ut31 ese34Minor allele frequency- A:0.03MN NA WA 306
    rs10505531,2
    --2965736(-) CATTTG/ATAACT 1 -- ut312Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for NAP1L4 (2965660 - 3013607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NAP1L4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744026CNV Deletion23290073
    nsv7648CNV Insertion18451855
    dgv1009n71CNV Loss21882294
    dgv1013n71CNV Loss21882294
    nsv832050CNV Loss17160897
    nsv8766CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NAP1L4
    DNA2.0 Custom Variant and Variant Library Synthesis for NAP1L4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601651    OMIM disorders: --

    8 diseases for NAP1L4:    
    About MalaCards
    adrenocortical carcinoma    beckwith-wiedemann syndrome    wilms tumor    rhabdomyosarcoma
    breast cancer    alcohol dependence    brain cancer    hiv-1

    1 disease from the University of Copenhagen DISEASES database for NAP1L4:
    Beckwith-Wiedemann syndrome

    NAP1L4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NAP1L4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 88.2 1 10777363 (1)
    wilms tumor 67.6 1 9325046 (1)
    tumors 7.48 1 9325046 (1)

    Genetic Association Database (GAD): NAP1L4
    Human Genome Epidemiology (HuGE) Navigator: NAP1L4 (1 document)

    Export disorders for NAP1L4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAP1L4 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with NAP1L4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. (PubMed id 8923002)1, 2, 3 Hu R.-J.... Feinberg A.P. (Hum. Mol. Genet. 1996)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (PubMed id 9325046)1, 9 Rodriguez P....Pelletier J. (Genomics 1997)
    6. NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (PubMed id 10764593)1, 9 Rodriguez P....Zannis-Hadjopoulos M. (J. Mol. Biol. 2000)
    7. NAP-2 is part of multi-protein complexes in HeLa cells. (PubMed id 15368365)1, 9 Rodriguez P....Zannis-Hadjopoulos M. (J. Cell. Biochem. 2004)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4676 HGNC: 7640 AceView: NAP1L4 Ensembl:ENSG00000205531 euGenes: HUgn4676
    ECgene: NAP1L4 H-InvDB: NAP1L4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAP1L4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAP1L4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAP1L4 gene:
    Search GeneIP for patents involving NAP1L4

    GeneCards and IP:
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