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Aliases for NAP1L4 Gene

Aliases for NAP1L4 Gene

  • Nucleosome Assembly Protein 1 Like 4 2 3 5
  • Nucleosome Assembly Protein 1-Like 4 2 3
  • Nucleosome Assembly Protein 2 3 4
  • NAP-2 3 4
  • NAP2 3 4
  • Nucleosome Assembly Protein 1-Like 4b 3
  • NAP1L4b 3
  • NAP2L 3
  • HNAP2 3

External Ids for NAP1L4 Gene

Previous GeneCards Identifiers for NAP1L4 Gene

  • GC11M003025
  • GC11M003216
  • GC11M002924
  • GC11M002929
  • GC11M002919
  • GC11M002922
  • GC11M002754
  • GC11M002965

Summaries for NAP1L4 Gene

Entrez Gene Summary for NAP1L4 Gene

  • This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAP1L4 Gene

NAP1L4 (Nucleosome Assembly Protein 1 Like 4) is a Protein Coding gene. Diseases associated with NAP1L4 include Beckwith-Wiedemann Syndrome and Wilms Tumor Susceptibility-5. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is NAP1L1.

UniProtKB/Swiss-Prot for NAP1L4 Gene

  • Acts as histone chaperone in nucleosome assembly.

Gene Wiki entry for NAP1L4 Gene

Additional gene information for NAP1L4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L4 Gene

Genomics for NAP1L4 Gene

Regulatory Elements for NAP1L4 Gene

Enhancers for NAP1L4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H002939 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.2 +51.4 51404 2 GTF2F1 PKNOX1 MAX BMI1 RAD21 ZNF316 POLR2A HNF4G RCOR1 FOS NAP1L4 ENSG00000183562 SLC22A18AS SNORA54 SLC22A18 KCNQ1 PHLDA2 KCNQ1-AS1 GC11M002963 PIR57698
GH11H003013 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -22.6 -22596 2.4 POLR2A NR2F1 IKZF1 NBN DPF2 RELA ENSG00000183562 NAP1L4 MRGPRG CARS-AS1 GC11M002982
GH11H003048 1.5 Ensembl ENCODE dbSUPER 16.7 -58.1 -58090 3.9 HDGF PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 ZNF143 FOS ATF7 RUNX3 NAP1L4 ENSG00000183562 RNU1-91P GC11M003048 CARS
GH11H003055 1.4 Ensembl ENCODE 16 -65.1 -65123 4.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ENSG00000183562 NAP1L4 CARS GC11M003048 RNU1-91P
GH11H002932 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +59.0 59023 2.2 TBP JUN MAX ZMYM3 SIN3A POLR2A NFYB ZNF143 RCOR1 FOS ENSG00000183562 NAP1L4 PHLDA2 OSBPL5 KCNQ1 SNORA54 GC11M002964 GC11M002963 PIR57698
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAP1L4 on UCSC Golden Path with GeneCards custom track

Promoters for NAP1L4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036018 1177 3601 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 FOS SP3 SP5

Genomic Locations for NAP1L4 Gene

Genomic Locations for NAP1L4 Gene
47,948 bases
Minus strand

Genomic View for NAP1L4 Gene

Genes around NAP1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L4 Gene

Proteins for NAP1L4 Gene

  • Protein details for NAP1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleosome assembly protein 1-like 4
    Protein Accession:
    Secondary Accessions:
    • B2R6J4
    • F5HFY4

    Protein attributes for NAP1L4 Gene

    375 amino acids
    Molecular mass:
    42823 Da
    Quaternary structure:
    • Interacts with core (H2A, H2B, H3, H4) and linker (H1) histones.

    Alternative splice isoforms for NAP1L4 Gene


neXtProt entry for NAP1L4 Gene

Post-translational modifications for NAP1L4 Gene

  • Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.
  • Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).
  • Ubiquitination at Lys26, Lys71, posLast=9494, Lys105, posLast=146146, and posLast=282282
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAP1L4 Gene

Domains & Families for NAP1L4 Gene

Gene Families for NAP1L4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAP1L4 Gene

Suggested Antigen Peptide Sequences for NAP1L4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L4: view

Function for NAP1L4 Gene

Molecular function for NAP1L4 Gene

GENATLAS Biochemistry:
nucleosome assembly protein 1-like 4, excluded of the imprinting domain,interacting with core and linker histones,putative chaperone
UniProtKB/Swiss-Prot Function:
Acts as histone chaperone in nucleosome assembly.

Phenotypes From GWAS Catalog for NAP1L4 Gene

Gene Ontology (GO) - Molecular Function for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 22190034
GO:0031491 nucleosome binding IDA 9325046
GO:0051082 unfolded protein binding TAS 9325046
genes like me logo Genes that share ontologies with NAP1L4: view

Phenotypes for NAP1L4 Gene

genes like me logo Genes that share phenotypes with NAP1L4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L4 Gene

Localization for NAP1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L4 Gene

Nucleus. Cytoplasm. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase (PubMed:9325046). Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary (PubMed:10764593). {ECO:0000269 PubMed:10764593, ECO:0000269 PubMed:9325046}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9325046
GO:0005737 cytoplasm IDA,IEA 9325046
genes like me logo Genes that share ontologies with NAP1L4: view

Pathways & Interactions for NAP1L4 Gene

SuperPathways for NAP1L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IDA 9325046
genes like me logo Genes that share ontologies with NAP1L4: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L4 Gene

Drugs & Compounds for NAP1L4 Gene

(1) Drugs for NAP1L4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NAP1L4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAP1L4: view

Transcripts for NAP1L4 Gene

Unigene Clusters for NAP1L4 Gene

Nucleosome assembly protein 1-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L4 Gene

No ASD Table

Relevant External Links for NAP1L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAP1L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAP1L4 Gene

Protein tissue co-expression partners for NAP1L4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L4 Gene:


SOURCE GeneReport for Unigene cluster for NAP1L4 Gene:


mRNA Expression by UniProt/SwissProt for NAP1L4 Gene:

Tissue specificity: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis.

Evidence on tissue expression from TISSUES for NAP1L4 Gene

  • Nervous system(5)
  • Liver(4.5)
  • Muscle(4.4)
  • Kidney(2.6)
  • Lung(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with NAP1L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L4 Gene

Orthologs for NAP1L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAP1L4 34 33
  • 99.02 (n)
(Monodelphis domestica)
Mammalia NAP1L4 34
  • 90 (a)
(Canis familiaris)
Mammalia NAP1L4 33 34
  • 88.95 (n)
(Bos Taurus)
Mammalia NAP1L4 33 34
  • 87.28 (n)
(Mus musculus)
Mammalia Nap1l4 33 16 34
  • 85.74 (n)
(Rattus norvegicus)
Mammalia Nap1l4 33
  • 85.74 (n)
(Gallus gallus)
Aves NAP1L4 33 34
  • 83.14 (n)
(Anolis carolinensis)
Reptilia NAP1L4 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nap1l4 33
  • 74.14 (n)
(Danio rerio)
Actinopterygii nap1l4b 33 34
  • 71.7 (n)
nap1l4a 34
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nap1 35 34
  • 51 (a)
EG:BACR7A4.18 35
  • 34 (a)
CG5017 34
  • 33 (a)
CG3708 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea nap-1 33 34
  • 51.78 (n)
D2096.8 35
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 34 36
  • 30 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nap2 33
  • 48.97 (n)
Species where no ortholog for NAP1L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAP1L4 Gene

Gene Tree for NAP1L4 (if available)
Gene Tree for NAP1L4 (if available)

Paralogs for NAP1L4 Gene

Paralogs for NAP1L4 Gene Pseudogenes for NAP1L4 Gene

genes like me logo Genes that share paralogs with NAP1L4: view

Variants for NAP1L4 Gene

Sequence variations from dbSNP and Humsavar for NAP1L4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000005175 -- 2,969,462(+) CCACA(G/T)GAAGA intron-variant
rs1000046712 -- 2,966,214(+) TATGG(C/G)ACACA intron-variant
rs1000077871 -- 2,966,012(+) CAGTG(A/G)GGAAA intron-variant
rs1000222533 -- 2,944,264(+) TGGGG(A/G)GGCTA downstream-variant-500B
rs1000301354 -- 2,986,835(+) GTTGG(C/T)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAP1L4 Gene

Variant ID Type Subtype PubMed ID
nsv8766 CNV loss 18304495
nsv832050 CNV loss 17160897
nsv7648 CNV insertion 18451855
nsv472060 CNV novel sequence insertion 20440878
esv3625132 CNV gain 21293372
esv2744026 CNV deletion 23290073

Variation tolerance for NAP1L4 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAP1L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L4 Gene

Disorders for NAP1L4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NAP1L4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
wilms tumor susceptibility-5
  • wilms tumor
antenatal bartter syndrome
  • bartter syndrome, furosemide type
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NAP1L4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NAP1L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L4 Gene

Publications for NAP1L4 Gene

  1. NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (PMID: 10764593) Rodriguez P … Zannis-Hadjopoulos M (Journal of molecular biology 2000) 3 4 22 60
  2. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (PMID: 9325046) Rodriguez P … Pelletier J (Genomics 1997) 3 4 22 60
  3. A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. (PMID: 8923002) Hu RJ … Feinberg AP (Human molecular genetics 1996) 2 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for NAP1L4 Gene

Sources for NAP1L4 Gene

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