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Aliases & Descriptions for NAP1L4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC4565 2 | | NAP2 1, 2, 3, 5 | | NAP2L 2, 5 | | OTTHUMP00000012671 2 | | hNAP2 2 |
| | | Descriptions |
|---|
| Nucleosome assembly protein 2 2, 3 | | nucleosome assembly protein 1-like 4 2 |
|
| | Search outside databases for aliases for NAP1L4 genePrevious GC identifers: GC11M003025 GC11M003216 GC11M002924 GC11M002929 GC11M002919 |
Summaries for NAP1L4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAP1L4: This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq] Gene Wiki entry for NAP1L4 |
Genomic Location for NAP1L4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAP1L4 gene 
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5NAP1L4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M002922:
(about GC identifiers)
Start:
|
2,922,236 bp from pter |
End:
|
2,970,183 bp from pter |
Size:
|
47,948 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_009237.17
| Proteins for NAP1L4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NP1L4_HUMAN, Q99733 (See
protein sequence)Recommended Name: Nucleosome assembly protein 1-like 4 Size: 375 amino acids; 42823 Da
Subcellular location: NucleusPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005960.1
ENSEMBL proteins: ENSP00000382533 ENSP00000382523 ENSP00000369915
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NAP1L4: Assays for NAP1L4: | Protein
Domains/ Families for NAP1L4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99733
ProtoNet protein and cluster: Q99733 1 Blocks protein family: IPB002164 Nucleosome assembly protein (NAP)
UniProtKB/Swiss-Prot: NP1L4_HUMAN, Q99733Similarity: Belongs to the nucleosome assembly protein (NAP) family | Gene Function for NAP1L4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005969
Applied Biosystems Silencer® siRNAs for NAP1L4
Sigma-Aldrich siRNA for NAP1L4  Sigma-Aldrich shRNA for NAP1L4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005969                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005969                                  untagged cDNA clones in CMV expression vector (see all 2): AK095320 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005969
Genatlas biochemistry entry for NAP1L4:nucleosome assembly protein 1-like 4, excluded of the imprinting domain,interacting with core and linker histones,putative chaperone1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051082 | unfolded protein binding |
TAS | 9325046 | About this table | Pathways & Interactions for NAP1L4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/15 Interacting proteins for NAP1L4 (ENSP000003699153) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for NAP1L4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAP1L4
|
Transcripts for NAP1L4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005969
Sigma-Aldrich siRNA for NAP1L4  Sigma-Aldrich shRNA for NAP1L4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005969 REFSEQ mRNAs for NAP1L4 gene: NM_005969.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005969               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005969                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005969                                  untagged cDNA clones in CMV expression vector (see all 2): AK095320  Additional cDNA sequence: AK299515.1 AK311098.1 AK312599.1 AK316242.1 AK316324.1 AK316548.1 BC022090.2 CR624939.1 U77456.1 24/29 DOTS entries (see all 29
): DT.448916 DT.95197346 DT.100798067 DT.92462968 DT.120697094 DT.97769343 DT.100811147 DT.92462973 DT.86854900 DT.439912 DT.120697081 DT.120697111 DT.101968316 DT.91745205 DT.92063326 DT.95192027 DT.95197340 DT.120697077 DT.40298417 DT.95360129 DT.100798070 DT.102842833 DT.120697088 DT.120697146 24/569 AceView cDNA sequences (see all 569
):N71060 BQ653221 AI350273 BM765931 BE253491 CB108970 BI087561 BM710883 BG820129 BQ219178 BX394357 BM982895 AI635549 BX479631 AI373211 AA448113 BM799809 AW246975 BQ027034 BI861430 BM724553 NM_005969 BM695399 AU138864
highest scoring ESTs for NAP1L4:U77456 AU099131 BI601589 BM834137 BU598621 CA338105 AL135252 AU130576 AU131441 AU139058 Unigene Cluster for NAP1L4: Nucleosome assembly protein 1-like 4 Hs.501684 [show with all ESTs]Unigene Representative Sequence: NM_005969
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000399624
ENST00000399614
ENST00000380542
|
Expression for NAP1L4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAP1L4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAP1L4
1 / 2 / 3 8 probe-sets matching NAP1L4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCATAGCTGG
SOURCE GeneReport for Unigene cluster: Hs.501684
Expression variation in blood from EXPOLDB for NAP1L4 UniProtKB/Swiss-Prot: NP1L4_HUMAN, Q99733Tissue specificity: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis |
Orthologs for NAP1L4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAP1L4 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for NAP1L4
ENSEMBL Gene Tree for NAP1L4 | Paralogs for NAP1L4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAP1L4 gene
- NAP1L62 NAP1L32 NAP1L22 NAP1L52 NAP1L12
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for NAP1L4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAP1L4 (up to first 250kb)
|
Disorders & Mutations for NAP1L4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601651
3 Novoseek disease relationships for NAP1L4 gene
About this table
|
Medical News for NAP1L4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAP1L4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/25 PubMed articles for NAP1L4 gene (see all 25
):- A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. (PubMed id 8923002)2, 3, 4 Hu R.-J.... Feinberg A.P. (1996)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)3, 4 Nousiainen M.... Koerner R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (PubMed id 9325046)1, 3 Rodriguez P....Pelletier J. (1997)
- NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (PubMed id 10764593)1, 3 Rodriguez P....Zannis-Hadjopoulos M. (2000)
- NAP-2 is part of multi-protein complexes in HeLa cells. (PubMed id 15368365)1, 3 Rodriguez P....Zannis-Hadjopoulos M. (2004)
- Nucleosome formation with the testis-specific histone H3 variant, H3t, by human nucleosome assembly proteins in vitro. (PubMed id 18281699)3 Tachiwana H....Kurumizaka H. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)4 Han G.... Gu J. (2008)
|
Search for NAP1L4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAP1L4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAP1L4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAP1L4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAP1L4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAP1L4:

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