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Aliases for NAP1L4 Gene

Aliases for NAP1L4 Gene

  • Nucleosome Assembly Protein 1 Like 4 2 3
  • Nucleosome Assembly Protein 1-Like 4 2 5
  • Nucleosome Assembly Protein 2 3 4
  • NAP-2 3 4
  • NAP2 3 4
  • Nucleosome Assembly Protein 1-Like 4b 3
  • NAP1L4b 3
  • NAP2L 3
  • HNAP2 3

External Ids for NAP1L4 Gene

Previous GeneCards Identifiers for NAP1L4 Gene

  • GC11M003025
  • GC11M003216
  • GC11M002924
  • GC11M002929
  • GC11M002919
  • GC11M002922
  • GC11M002754
  • GC11M002965

Summaries for NAP1L4 Gene

Entrez Gene Summary for NAP1L4 Gene

  • This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAP1L4 Gene

NAP1L4 (Nucleosome Assembly Protein 1 Like 4) is a Protein Coding gene. Diseases associated with NAP1L4 include Beckwith-Wiedemann Syndrome and Wilms Tumor Susceptibility-5. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is NAP1L6.

Gene Wiki entry for NAP1L4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L4 Gene

Genomics for NAP1L4 Gene

Regulatory Elements for NAP1L4 Gene

Enhancers for NAP1L4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAP1L4 on UCSC Golden Path with GeneCards custom track

Promoters for NAP1L4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAP1L4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAP1L4 Gene

2,944,430 bp from pter
2,992,377 bp from pter
47,948 bases
Minus strand

Genomic View for NAP1L4 Gene

Genes around NAP1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L4 Gene

Proteins for NAP1L4 Gene

  • Protein details for NAP1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleosome assembly protein 1-like 4
    Protein Accession:
    Secondary Accessions:
    • B2R6J4
    • F5HFY4

    Protein attributes for NAP1L4 Gene

    375 amino acids
    Molecular mass:
    42823 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L4 Gene


neXtProt entry for NAP1L4 Gene

Proteomics data for NAP1L4 Gene at MOPED

Post-translational modifications for NAP1L4 Gene

  • Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).
  • Ubiquitination at Lys 26, Lys 71, Lys 94, Lys 105, Lys 146, and Lys 282
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAP1L4 Gene

Domains & Families for NAP1L4 Gene

Protein Domains for NAP1L4 Gene

Suggested Antigen Peptide Sequences for NAP1L4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L4: view

No data available for Gene Families for NAP1L4 Gene

Function for NAP1L4 Gene

Molecular function for NAP1L4 Gene

GENATLAS Biochemistry:
nucleosome assembly protein 1-like 4, excluded of the imprinting domain,interacting with core and linker histones,putative chaperone

Gene Ontology (GO) - Molecular Function for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0051082 unfolded protein binding TAS 9325046
genes like me logo Genes that share ontologies with NAP1L4: view

Phenotypes for NAP1L4 Gene

genes like me logo Genes that share phenotypes with NAP1L4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L4 Gene

Localization for NAP1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L4 Gene

Subcellular locations from

Jensen Localization Image for NAP1L4 Gene COMPARTMENTS Subcellular localization image for NAP1L4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NAP1L4 Gene

Pathways & Interactions for NAP1L4 Gene

SuperPathways for NAP1L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L4 Gene


No data available for Pathways by source and SIGNOR curated interactions for NAP1L4 Gene

Drugs & Compounds for NAP1L4 Gene

(1) Drugs for NAP1L4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NAP1L4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAP1L4: view

Transcripts for NAP1L4 Gene

Unigene Clusters for NAP1L4 Gene

Nucleosome assembly protein 1-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L4 Gene

No ASD Table

Relevant External Links for NAP1L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAP1L4 Gene

mRNA expression in normal human tissues for NAP1L4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAP1L4 Gene

SOURCE GeneReport for Unigene cluster for NAP1L4 Gene Hs.731784

mRNA Expression by UniProt/SwissProt for NAP1L4 Gene

Tissue specificity: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis.
genes like me logo Genes that share expression patterns with NAP1L4: view

Protein tissue co-expression partners for NAP1L4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for NAP1L4 Gene

Orthologs for NAP1L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAP1L4 35
  • 87.28 (n)
  • 94.22 (a)
NAP1L4 36
  • 91 (a)
(Canis familiaris)
Mammalia NAP1L4 35
  • 88.95 (n)
  • 95.72 (a)
NAP1L4 36
  • 93 (a)
(Mus musculus)
Mammalia Nap1l4 35
  • 85.74 (n)
  • 94.8 (a)
Nap1l4 16
Nap1l4 36
  • 95 (a)
(Pan troglodytes)
Mammalia NAP1L4 35
  • 99.02 (n)
  • 99.2 (a)
NAP1L4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nap1l4 35
  • 85.74 (n)
  • 94.22 (a)
(Monodelphis domestica)
Mammalia NAP1L4 36
  • 90 (a)
(Gallus gallus)
Aves NAP1L4 35
  • 83.14 (n)
  • 88.37 (a)
NAP1L4 36
  • 88 (a)
(Anolis carolinensis)
Reptilia NAP1L4 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nap1l4 35
  • 74.14 (n)
  • 80 (a)
(Danio rerio)
Actinopterygii nap1l4b 35
  • 71.7 (n)
  • 73.58 (a)
nap1l4a 36
  • 66 (a)
nap1l4b 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR7A4.18 37
  • 34 (a)
Nap1 37
  • 51 (a)
CG3708 36
  • 31 (a)
CG5017 36
  • 33 (a)
Nap1 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea D2096.8 37
  • 37 (a)
nap-1 35
  • 51.78 (n)
  • 42.96 (a)
nap-1 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 36
  • 30 (a)
NAP1 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nap2 35
  • 48.97 (n)
  • 39.73 (a)
Species with no ortholog for NAP1L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAP1L4 Gene

Gene Tree for NAP1L4 (if available)
Gene Tree for NAP1L4 (if available)

Paralogs for NAP1L4 Gene

Paralogs for NAP1L4 Gene Pseudogenes for NAP1L4 Gene

genes like me logo Genes that share paralogs with NAP1L4: view

Variants for NAP1L4 Gene

Sequence variations from dbSNP and Humsavar for NAP1L4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs737872 -- 2,962,264(+) GGTGG(G/T)GCATG intron-variant
rs756692 -- 2,952,014(+) GTCAC(A/G/T)CAAAA intron-variant
rs915999 -- 2,951,378(-) TGTGG(A/T)TTGTG intron-variant
rs1050311 -- 2,959,872(-) CGACT(A/G)CTTTA reference, missense
rs1050323 -- 2,945,442(-) TTTTG(A/C)TTAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAP1L4 Gene

Variant ID Type Subtype PubMed ID
dgv1009n71 CNV Loss 21882294
nsv832050 CNV Loss 17160897
dgv1013n71 CNV Loss 21882294
nsv7648 CNV Insertion 18451855
nsv8766 CNV Loss 18304495
esv2744026 CNV Deletion 23290073

Variation tolerance for NAP1L4 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NAP1L4 Gene

Disorders for NAP1L4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAP1L4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
wilms tumor susceptibility-5
  • wilms tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NAP1L4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NAP1L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L4 Gene

Publications for NAP1L4 Gene

  1. A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. (PMID: 8923002) Hu R.-J. … Feinberg A.P. (Hum. Mol. Genet. 1996) 2 3 4 67
  2. NAP-2 is part of multi-protein complexes in HeLa cells. (PMID: 15368365) Rodriguez P. … Zannis-Hadjopoulos M. (J. Cell. Biochem. 2004) 3 23
  3. NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (PMID: 10764593) Rodriguez P. … Zannis-Hadjopoulos M. (J. Mol. Biol. 2000) 3 23
  4. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (PMID: 9325046) Rodriguez P. … Pelletier J. (Genomics 1997) 3 23
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for NAP1L4 Gene

Sources for NAP1L4 Gene