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Aliases for NAP1L3 Gene

Aliases for NAP1L3 Gene

  • Nucleosome Assembly Protein 1 Like 3 2 3 5
  • Nucleosome Assembly Protein 1-Like 3 2 3
  • MB20 3
  • NPL3 3
  • BNAP 4

External Ids for NAP1L3 Gene

Previous GeneCards Identifiers for NAP1L3 Gene

  • GC0XM088209
  • GC0XM089906
  • GC0XM090961
  • GC0XM091697
  • GC0XM092732
  • GC0XM092925
  • GC0XM082748

Summaries for NAP1L3 Gene

Entrez Gene Summary for NAP1L3 Gene

  • This gene is intronless and encodes a member of the nucleosome assembly protein (NAP) family. This gene is linked closely to a region of genes responsible for several X-linked cognitive disability syndromes. [provided by RefSeq, Dec 2010]

GeneCards Summary for NAP1L3 Gene

NAP1L3 (Nucleosome Assembly Protein 1 Like 3) is a Protein Coding gene. An important paralog of this gene is NAP1L1.

Additional gene information for NAP1L3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L3 Gene

Genomics for NAP1L3 Gene

Regulatory Elements for NAP1L3 Gene

Enhancers for NAP1L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH093672 0.7 ENCODE 0.7 +0.2 185 2.3 MAZ PKNOX1 ZNF362 L3MBTL2 ZNF76 NFYC SP2 ZNF384 BRCA1 POLR2A NAP1L3 GC0XM093663
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAP1L3 on UCSC Golden Path with GeneCards custom track

Promoters for NAP1L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247491 182 2199 PKNOX1 ZNF362 L3MBTL2 ZNF76 NFYC SP2 ZNF384 BRCA1 POLR2A CHD2

Genomic Locations for NAP1L3 Gene

Genomic Locations for NAP1L3 Gene
2,758 bases
Minus strand

Genomic View for NAP1L3 Gene

Genes around NAP1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L3 Gene

Proteins for NAP1L3 Gene

  • Protein details for NAP1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleosome assembly protein 1-like 3
    Protein Accession:
    Secondary Accessions:
    • B2RCM0
    • O60788

    Protein attributes for NAP1L3 Gene

    506 amino acids
    Molecular mass:
    57593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAP1L3 Gene

Post-translational modifications for NAP1L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAP1L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L3 Gene

Domains & Families for NAP1L3 Gene

Gene Families for NAP1L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAP1L3 Gene

Suggested Antigen Peptide Sequences for NAP1L3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L3: view

Function for NAP1L3 Gene

Molecular function for NAP1L3 Gene

GENATLAS Biochemistry:
nucleosome assembly protein-like 3,tightly linked to DXS990

Phenotypes for NAP1L3 Gene

genes like me logo Genes that share phenotypes with NAP1L3: view

miRNA for NAP1L3 Gene

miRTarBase miRNAs that target NAP1L3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L3 Gene

Localization for NAP1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAP1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NAP1L3: view

Pathways & Interactions for NAP1L3 Gene

SuperPathways for NAP1L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with NAP1L3: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L3 Gene

Drugs & Compounds for NAP1L3 Gene

No Compound Related Data Available

Transcripts for NAP1L3 Gene

mRNA/cDNA for NAP1L3 Gene

Unigene Clusters for NAP1L3 Gene

Nucleosome assembly protein 1-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L3 Gene

No ASD Table

Relevant External Links for NAP1L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAP1L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.6), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Hypothalamus (x5.4), and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for NAP1L3 Gene

This gene is overexpressed in Fetal gut (50.5) and Gallbladder (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAP1L3 Gene

Protein tissue co-expression partners for NAP1L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAP1L3 Gene:


SOURCE GeneReport for Unigene cluster for NAP1L3 Gene:


Evidence on tissue expression from TISSUES for NAP1L3 Gene

  • Nervous system(4.9)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with NAP1L3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L3 Gene

Orthologs for NAP1L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAP1L3 33 34
  • 99.6 (n)
(Canis familiaris)
Mammalia NAP1L3 33 34
  • 85.59 (n)
(Bos Taurus)
Mammalia NAP1L3 33 34
  • 82.34 (n)
(Rattus norvegicus)
Mammalia Nap1l3 33
  • 80.19 (n)
(Mus musculus)
Mammalia Nap1l3 33 16 34
  • 80.03 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
-- 34
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
(Gallus gallus)
Aves -- 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
(Danio rerio)
Actinopterygii nap1l1 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5017 34
  • 31 (a)
Nap1 34
  • 31 (a)
CG3708 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea nap-1 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 34
  • 32 (a)
Species where no ortholog for NAP1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAP1L3 Gene

Gene Tree for NAP1L3 (if available)
Gene Tree for NAP1L3 (if available)

Paralogs for NAP1L3 Gene

Paralogs for NAP1L3 Gene

(2) SIMAP similar genes for NAP1L3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NAP1L3: view

Variants for NAP1L3 Gene

Sequence variations from dbSNP and Humsavar for NAP1L3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs863223375 Benign 93,671,995(-) TAATG(C/G)ATCAT upstream-variant-2KB, reference, missense
rs1001253882 -- 93,671,039(+) TAGAA(C/T)ACAAT utr-variant-3-prime
rs1001994084 -- 93,674,648(+) GAAGT(C/T)TAAAA intron-variant, upstream-variant-2KB
rs1002288948 -- 93,671,512(+) ACACT(A/G)TGTAG utr-variant-3-prime
rs1003326723 -- 93,673,944(+) CACCC(C/T)GAATT intron-variant, upstream-variant-2KB

Variation tolerance for NAP1L3 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAP1L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAP1L3 Gene

Disorders for NAP1L3 Gene

Relevant External Links for NAP1L3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAP1L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAP1L3 Gene

Publications for NAP1L3 Gene

  1. Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins. (PMID: 8976385) Watanabe TK … Takahashi E (Cytogenetics and cell genetics 1996) 2 3 4 22 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for NAP1L3 Gene

Sources for NAP1L3 Gene

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