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Aliases for NAP1L2 Gene

Aliases for NAP1L2 Gene

  • Nucleosome Assembly Protein 1-Like 2 2 3
  • BPX 3 4 6
  • Brain-Specific Protein, X-Linked 3 4
  • Brain Specific Gene BPX 3

External Ids for NAP1L2 Gene

Previous GeneCards Identifiers for NAP1L2 Gene

  • GC0XM068245
  • GC0XM069606
  • GC0XM070646
  • GC0XM071298
  • GC0XM072215
  • GC0XM072348
  • GC0XM066066

Summaries for NAP1L2 Gene

Entrez Gene Summary for NAP1L2 Gene

  • The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAP1L2 Gene

NAP1L2 (Nucleosome Assembly Protein 1-Like 2) is a Protein Coding gene. An important paralog of this gene is NAP1L4.

UniProtKB/Swiss-Prot for NAP1L2 Gene

  • Acidic protein which may be involved in interactions with other proteins or DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L2 Gene

Genomics for NAP1L2 Gene

Regulatory Elements for NAP1L2 Gene

Genomic Location for NAP1L2 Gene

Start:
73,212,299 bp from pter
End:
73,214,874 bp from pter
Size:
2,576 bases
Orientation:
Minus strand

Genomic View for NAP1L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAP1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L2 Gene

Proteins for NAP1L2 Gene

  • Protein details for NAP1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW6-NP1L2_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 2
    Protein Accession:
    Q9ULW6
    Secondary Accessions:
    • B2RE61
    • B4E161
    • Q8TAN6

    Protein attributes for NAP1L2 Gene

    Size:
    460 amino acids
    Molecular mass:
    52542 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAP1L2 Gene

Proteomics data for NAP1L2 Gene at MOPED

Post-translational modifications for NAP1L2 Gene

  • Ubiquitination at Lys267
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L2 Gene

Domains for NAP1L2 Gene

Protein Domains for NAP1L2 Gene

Suggested Antigen Peptide Sequences for NAP1L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULW6

UniProtKB/Swiss-Prot:

NP1L2_HUMAN :
  • Q9ULW6
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L2: view

No data available for Gene Families for NAP1L2 Gene

Function for NAP1L2 Gene

Molecular function for NAP1L2 Gene

GENATLAS Biochemistry: nucleosome assembly protein 1-like 2,murine Bpx homolog
UniProtKB/Swiss-Prot Function: Acidic protein which may be involved in interactions with other proteins or DNA.

Gene Ontology (GO) - Molecular Function for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18985028
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

Animal Model Products

CRISPR Products

miRNA for NAP1L2 Gene

miRTarBase miRNAs that target NAP1L2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAP1L2 Gene

Localization for NAP1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAP1L2 Gene COMPARTMENTS Subcellular localization image for NAP1L2 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

Pathways for NAP1L2 Gene

SuperPathways for NAP1L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0035066 positive regulation of histone acetylation --
GO:0045666 positive regulation of neuron differentiation IEA --
GO:0071442 positive regulation of histone H3-K14 acetylation IEA --
GO:2000035 regulation of stem cell division IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

No data available for Pathways by source for NAP1L2 Gene

Transcripts for NAP1L2 Gene

mRNA/cDNA for NAP1L2 Gene

(45) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L2 Gene

Nucleosome assembly protein 1-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAP1L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L2 Gene

No ASD Table

Relevant External Links for NAP1L2 Gene

GeneLoc Exon Structure for
NAP1L2
ECgene alternative splicing isoforms for
NAP1L2

Expression for NAP1L2 Gene

mRNA expression in normal human tissues for NAP1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.4), Brain - Anterior cingulate cortex (BA24) (5.7), and Brain - Cerebellar Hemisphere (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NAP1L2 Gene

SOURCE GeneReport for Unigene cluster for NAP1L2 Gene Hs.66180

genes like me logo Genes that share expressions with NAP1L2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NAP1L2 Gene

Orthologs for NAP1L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAP1L2 35
  • 99.71 (n)
  • 99.57 (a)
NAP1L2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia NAP1L2 35
  • 89.67 (n)
  • 85.37 (a)
NAP1L2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nap1l2 35
  • 84.53 (n)
  • 82.79 (a)
Nap1l2 16
Nap1l2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nap1l2 35
  • 84.71 (n)
  • 81.96 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nap1l1 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3708 36
  • 26 (a)
ManyToMany
CG5017 36
  • 32 (a)
ManyToMany
Nap1 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nap-1 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 36
  • 35 (a)
OneToMany
Species with no ortholog for NAP1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAP1L2 Gene

ENSEMBL:
Gene Tree for NAP1L2 (if available)
TreeFam:
Gene Tree for NAP1L2 (if available)

Paralogs for NAP1L2 Gene

Paralogs for NAP1L2 Gene

Selected SIMAP similar genes for NAP1L2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NAP1L2 Gene

genes like me logo Genes that share paralogs with NAP1L2: view

Variants for NAP1L2 Gene

Sequence variations from dbSNP and Humsavar for NAP1L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs15738 -- 73,212,392(+) ACTTT(C/T)AATGA utr-variant-3-prime
rs2362986 -- 73,213,152(-) GCTTG(A/T)TGCAA stop-gained, reference
rs2885665 -- 73,215,512(-) TTACT(A/T)GTCAC upstream-variant-2KB
rs3747405 -- 73,213,575(+) AGCAC(A/G)TAGGT synonymous-codon, reference
rs5938504 -- 73,214,974(+) AGATC(C/T)ATCAA upstream-variant-2KB

Relevant External Links for NAP1L2 Gene

HapMap Linkage Disequilibrium report
NAP1L2
Human Gene Mutation Database (HGMD)
NAP1L2
Locus Specific Mutation Databases (LSDB)
NAP1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAP1L2 Gene

Disorders for NAP1L2 Gene

No disorders were found for NAP1L2 Gene.

No data available for UniProtKB/Swiss-Prot for NAP1L2 Gene

Publications for NAP1L2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Control of neurulation by the nucleosome assembly protein-1-like 2. (PMID: 10932189) Rogner U.C. … Avner P. (Nat. Genet. 2000) 3 23
  3. Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. (PMID: 8789438) Rougeulle C. … Avner P. (Hum. Mol. Genet. 1996) 2 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. SNPs in the CpG island of NAP1L2: a possible link between DNA methylation and neural tube defects? (PMID: 12116227) Rogner U.C. … Avner P. (Am. J. Med. Genet. 2002) 3

Products for NAP1L2 Gene

Sources for NAP1L2 Gene

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