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Aliases for NAP1L2 Gene

Aliases for NAP1L2 Gene

  • Nucleosome Assembly Protein 1 Like 2 2 3
  • Nucleosome Assembly Protein 1-Like 2 2 5
  • Brain-Specific Protein, X-Linked 3 4
  • BPX 3 4
  • Brain Specific Gene BPX 3

External Ids for NAP1L2 Gene

Previous GeneCards Identifiers for NAP1L2 Gene

  • GC0XM068245
  • GC0XM069606
  • GC0XM070646
  • GC0XM071298
  • GC0XM072215
  • GC0XM072348
  • GC0XM066066

Summaries for NAP1L2 Gene

Entrez Gene Summary for NAP1L2 Gene

  • The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAP1L2 Gene

NAP1L2 (Nucleosome Assembly Protein 1 Like 2) is a Protein Coding gene. Diseases associated with NAP1L2 include Neural Tube Defects. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is NAP1L4.

UniProtKB/Swiss-Prot for NAP1L2 Gene

  • Acidic protein which may be involved in interactions with other proteins or DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L2 Gene

Genomics for NAP1L2 Gene

Regulatory Elements for NAP1L2 Gene

Enhancers for NAP1L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAP1L2 on UCSC Golden Path with GeneCards custom track

Promoters for NAP1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAP1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAP1L2 Gene

73,212,299 bp from pter
73,214,874 bp from pter
2,576 bases
Minus strand

Genomic View for NAP1L2 Gene

Genes around NAP1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L2 Gene

Proteins for NAP1L2 Gene

  • Protein details for NAP1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleosome assembly protein 1-like 2
    Protein Accession:
    Secondary Accessions:
    • B2RE61
    • B4E161
    • Q8TAN6

    Protein attributes for NAP1L2 Gene

    460 amino acids
    Molecular mass:
    52542 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L2 Gene


neXtProt entry for NAP1L2 Gene

Proteomics data for NAP1L2 Gene at MOPED

Post-translational modifications for NAP1L2 Gene

  • Ubiquitination at Lys 267
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L2 Gene

Domains & Families for NAP1L2 Gene

Protein Domains for NAP1L2 Gene

Suggested Antigen Peptide Sequences for NAP1L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L2: view

No data available for Gene Families for NAP1L2 Gene

Function for NAP1L2 Gene

Molecular function for NAP1L2 Gene

GENATLAS Biochemistry:
nucleosome assembly protein 1-like 2,murine Bpx homolog
UniProtKB/Swiss-Prot Function:
Acidic protein which may be involved in interactions with other proteins or DNA.
genes like me logo Genes that share phenotypes with NAP1L2: view

Animal Models for NAP1L2 Gene

MGI Knock Outs for NAP1L2:

Animal Model Products

miRNA for NAP1L2 Gene

miRTarBase miRNAs that target NAP1L2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAP1L2 Gene

Localization for NAP1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L2 Gene

Subcellular locations from

Jensen Localization Image for NAP1L2 Gene COMPARTMENTS Subcellular localization image for NAP1L2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NAP1L2 Gene

Pathways & Interactions for NAP1L2 Gene

SuperPathways for NAP1L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0071442 positive regulation of histone H3-K14 acetylation IEA --
GO:2000035 regulation of stem cell division IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L2 Gene

Drugs & Compounds for NAP1L2 Gene

No Compound Related Data Available

Transcripts for NAP1L2 Gene

mRNA/cDNA for NAP1L2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L2 Gene

Nucleosome assembly protein 1-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L2 Gene

No ASD Table

Relevant External Links for NAP1L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAP1L2 Gene

mRNA expression in normal human tissues for NAP1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.4), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for NAP1L2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAP1L2 Gene

SOURCE GeneReport for Unigene cluster for NAP1L2 Gene Hs.66180

genes like me logo Genes that share expression patterns with NAP1L2: view

Protein tissue co-expression partners for NAP1L2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NAP1L2 Gene

Orthologs for NAP1L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NAP1L2 35
  • 89.67 (n)
  • 85.37 (a)
NAP1L2 36
  • 87 (a)
(Mus musculus)
Mammalia Nap1l2 35
  • 84.53 (n)
  • 82.79 (a)
Nap1l2 16
Nap1l2 36
  • 83 (a)
(Pan troglodytes)
Mammalia NAP1L2 35
  • 99.71 (n)
  • 99.57 (a)
NAP1L2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nap1l2 35
  • 84.71 (n)
  • 81.96 (a)
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
-- 36
  • 30 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
-- 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Gallus gallus)
Aves -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
(Danio rerio)
Actinopterygii nap1l1 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3708 36
  • 26 (a)
CG5017 36
  • 32 (a)
Nap1 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea nap-1 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 36
  • 35 (a)
Species with no ortholog for NAP1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAP1L2 Gene

Gene Tree for NAP1L2 (if available)
Gene Tree for NAP1L2 (if available)

Paralogs for NAP1L2 Gene

Paralogs for NAP1L2 Gene

(4) SIMAP similar genes for NAP1L2 Gene using alignment to 3 proteins: Pseudogenes for NAP1L2 Gene

genes like me logo Genes that share paralogs with NAP1L2: view

Variants for NAP1L2 Gene

Sequence variations from dbSNP and Humsavar for NAP1L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747976071 -- 73,214,316(+) TTTTC(C/T)CCTTC reference, synonymous-codon
rs748028067 -- 73,213,605(+) TTGAA(A/G)TATTC reference, synonymous-codon
rs748193520 -- 73,216,811(+) TCAAT(A/G)CAATC upstream-variant-2KB
rs748238407 -- 73,215,883(+) TTTTT(A/T)AAAAT upstream-variant-2KB
rs748306761 -- 73,213,426(+) TTGTT(C/T)CCCAG reference, missense

Variation tolerance for NAP1L2 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAP1L2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAP1L2 Gene

Disorders for NAP1L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAP1L2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • spina bifida
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NAP1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NAP1L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L2 Gene

Publications for NAP1L2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Control of neurulation by the nucleosome assembly protein-1-like 2. (PMID: 10932189) Rogner U.C. … Avner P. (Nat. Genet. 2000) 3 23
  3. Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. (PMID: 8789438) Rougeulle C. … Avner P. (Hum. Mol. Genet. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Interaction between nucleosome assembly protein 1-like family members. (PMID: 21333655) Attia M. … Rogner U.C. (J. Mol. Biol. 2011) 3

Products for NAP1L2 Gene

Sources for NAP1L2 Gene