NAP1L2 Gene
protein-coding GIFtS: 49
GCID: GC0XM072348
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|
nucleosome assembly protein 1-like 2
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Aliases
for NAP1L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleosome Assembly Protein 1-Like 21 2 | | BPX1 2 3 | | Brain-Specific Protein, X-Linked2 3 | | MGC262431 | | Brain Specific Gene BPX2 |
Export aliases for NAP1L2 gene to outside databasesPrevious GC identifers: GC0XM068245 GC0XM069606 GC0XM070646 GC0XM071298 GC0XM072215 GC0XM066066 |
Summaries
for NAP1L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAP1L2:
The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encodedprotein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cellproliferation. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: NP1L2_HUMAN, Q9ULW6Function: Acidic protein which may be involved in interactions with other proteins or DNA (By similarity)
|
Genomic Views
for NAP1L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAP1L2 gene promoter:
Nkx3-1 GATA-3 Pbx1a POU3F1 CUTL1 C/EBPalpha GATA-2 GATA-1 AREB6 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAP1L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAP1L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.2 HGNC cytogenetic band: Xq13NAP1L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM072348: view genomic region
(about GC identifiers)
Start:
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72,432,135 bp from pter |
End:
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72,434,684 bp from pter |
Size:
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2,550 bases |
Orientation:
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minus strand |
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Proteins
for NAP1L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NP1L2_HUMAN, Q9ULW6 (See
protein sequence)Recommended Name: Nucleosome assembly protein 1-like 2 Size: 460 amino acids; 52542 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RE61 Q8TAN6Explore the universe of human proteins at neXtProt for NAP1L2: NX_Q9ULW6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULW6
NAP1L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068798.1
ENSEMBL proteins: ENSP00000362616 ENSP00000441555
Human Recombinant Protein Products for NAP1L2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0005678 | chromatin assembly complex |
-- | -- |
NAP1L2 for ontologies About GeneDecksing
NAP1L2 Antibody Products:
Assay Products for NAP1L2: |
Protein
Domains /
Families
for NAP1L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAP1L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9ULW6ProtoNet protein and cluster: Q9ULW6 1 Blocks protein family: IPB002164 Nucleosome assembly protein (NAP)
UniProtKB/Swiss-Prot: NP1L2_HUMAN, Q9ULW6Similarity: Belongs to the nucleosome assembly protein (NAP) family |
Function
for NAP1L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NP1L2_HUMAN, Q9ULW6Function: Acidic protein which may be involved in interactions with other proteins or DNA (By similarity) Genatlas biochemistry entry for NAP1L2:nucleosome assembly protein 1-like 2,murine Bpx homolog
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAP1L2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L2 |
|
Pathways & Interactions
for NAP1L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAP1L2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/13 Interacting proteins for NAP1L2 (Q9ULW62, 3 ENSP000003626164) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- |
NAP1L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NAP1L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAP1L2
Search CenterWatch for drugs/clinical trials and news about NAP1L2 / NP1L2
|
Transcripts
for NAP1L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAP1L2 gene: NM_021963.3 Unigene Clusters for NAP1L2: Nucleosome assembly protein 1-like 2 Hs.66180 [show with all ESTs], Hs.740565 [show with all ESTs]Unigene Representative Sequences: AK316569, NM_0219632 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373517(uc004ebi.3) ENST00000536638
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAP1L2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAP1L2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAP1L2 (NM_021963) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAP1L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAP1L2 |
Additional cDNA sequence: AB027013.1 AF136178.1 AK291297.1 AK303676.1 BC026325.1 2 DOTS entries: DT.309076 DT.97839188 24/45 AceView cDNA sequences (see all 45): BQ721589 F08328 CA771292 AI823491 BM725977 CA947068 CK826447 NM_021963 BF448963 BM683236 AB027013 AA634151 BM719302 Z41332 CD678482 AA156109 AI350825 AA081879 CK826446 AI205064 AF136178 CA946795 AA364883 AV659156
GeneLoc Exon Structure
|
Expression
for NAP1L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAP1L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATCACCTC
About this image
See NAP1L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAP1L2
SOURCE GeneReport for Unigene clusters: Hs.66180 Hs.740565
SABiosciences Custom PCR Arrays for NAP1L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAP1L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAP1L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAP1L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAP1L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L2 |
Orthologs
for NAP1L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAP1L2 gene from 4/20 species (see all 20) About this table
ENSEMBL Gene Tree for NAP1L2 (if available)
TreeFam Gene Tree for NAP1L2 (if available) |
Paralogs
for NAP1L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAP1L2 gene
- NAP1L32 NAP1L62 NAP1L42 NAP1L52 NAP1L12
5 SIMAP similar genes for NAP1L2 using alignment to 3 protein entries: NP1L2_HUMAN (see all proteins):NAP1L6 NAP1L4 NAP1L1 NAP1L4b NAP1L5
NAP1L2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NAP1L2
PGOHUM00000259279
|
Genomic Variants
for NAP1L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAP1L2 (72432135 - 72434684 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAP1L2: --
Locus Specific Mutation Databases (LSDB): NAP1L2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAP1L2 |
|
Disorders
/ Diseases
for NAP1L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAP1L2 for disorders About GeneDecksing
OMIM gene information: 300026
OMIM disorders: --
4  diseases for NAP1L2: About MalaCardsneural tube defect spina bifida neuronitis malaria
Export disorders for NAP1L2 gene to outside databases
|
Publications
for NAP1L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAP1L2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with NAP1L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. (PubMed id 8789438)1, 3 Rougeulle C. and Avner P. (1996)
- Control of neurulation by the nucleosome assembly protein-1-like 2. (PubMed id 10932189)1, 9 Rogner U.C....Avner P. (2000)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- Interaction between nucleosome assembly protein 1-lik e family members. (PubMed id 21333655)1 Attia M....Rogner U.C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NAP1L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAP1L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAP1L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAP1L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAP1L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAP1L2 gene:
Search GeneIP for patents involving NAP1L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAP1L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | NAP1L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L2 |
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