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Aliases for NAP1L2 Gene

Aliases for NAP1L2 Gene

  • Nucleosome Assembly Protein 1 Like 2 2 3 5
  • Nucleosome Assembly Protein 1-Like 2 2 3
  • Brain-Specific Protein, X-Linked 3 4
  • BPX 3 4
  • Brain Specific Gene BPX 3

External Ids for NAP1L2 Gene

Previous GeneCards Identifiers for NAP1L2 Gene

  • GC0XM068245
  • GC0XM069606
  • GC0XM070646
  • GC0XM071298
  • GC0XM072215
  • GC0XM072348
  • GC0XM066066

Summaries for NAP1L2 Gene

Entrez Gene Summary for NAP1L2 Gene

  • The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAP1L2 Gene

NAP1L2 (Nucleosome Assembly Protein 1 Like 2) is a Protein Coding gene. Diseases associated with NAP1L2 include Neural Tube Defects. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is NAP1L1.

UniProtKB/Swiss-Prot for NAP1L2 Gene

  • Acidic protein which may be involved in interactions with other proteins or DNA.

Additional gene information for NAP1L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L2 Gene

Genomics for NAP1L2 Gene

Regulatory Elements for NAP1L2 Gene

Enhancers for NAP1L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH073943 1.2 ENCODE 26.5 -729.7 -729666 2 MLX FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A FTX ENSG00000271199 RAB11FIP1P1 JPX DDX3P1 RN7SL648P CHIC1 ENSG00000228906 TOMM20P4 ENSG00000271533
GH0XH072272 1.1 ENCODE 17 +940.0 939969 5 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF143 TAF1 NONO LOC100420758 ERCC6L OGT RTL5 LOC392489 ENSG00000229601 TOMM20P4 NAP1L2
GH0XH073566 0.4 FANTOM5 3 -352.0 -351969 0 CHIC1 NAP1L2 CDX4 PIR39676
GH0XH073214 0.7 ENCODE 0.7 -0.1 -88 1 PKNOX1 ZNF362 SIN3A SP2 YY1 ZFHX2 CBX8 POLR2A ZNF341 ZNF629 FAM226B NAP1L2 TOMM20P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAP1L2 on UCSC Golden Path with GeneCards custom track

Promoters for NAP1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247233 173 1799 PKNOX1 ZNF362 SP2 YY1 CBX8 POLR2A ZNF341 ZNF629 NFE2 CREM

Genomic Location for NAP1L2 Gene

Chromosome:
X
Start:
73,212,299 bp from pter
End:
73,214,874 bp from pter
Size:
2,576 bases
Orientation:
Minus strand

Genomic View for NAP1L2 Gene

Genes around NAP1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L2 Gene

Proteins for NAP1L2 Gene

  • Protein details for NAP1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW6-NP1L2_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 2
    Protein Accession:
    Q9ULW6
    Secondary Accessions:
    • B2RE61
    • B4E161
    • Q8TAN6

    Protein attributes for NAP1L2 Gene

    Size:
    460 amino acids
    Molecular mass:
    52542 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAP1L2 Gene

Post-translational modifications for NAP1L2 Gene

  • Ubiquitination at Lys267
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L2 Gene

Domains & Families for NAP1L2 Gene

Gene Families for NAP1L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAP1L2 Gene

Suggested Antigen Peptide Sequences for NAP1L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULW6

UniProtKB/Swiss-Prot:

NP1L2_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L2: view

Function for NAP1L2 Gene

Molecular function for NAP1L2 Gene

GENATLAS Biochemistry:
nucleosome assembly protein 1-like 2,murine Bpx homolog
UniProtKB/Swiss-Prot Function:
Acidic protein which may be involved in interactions with other proteins or DNA.

Gene Ontology (GO) - Molecular Function for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18985028
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with NAP1L2: view
genes like me logo Genes that share phenotypes with NAP1L2: view

Animal Models for NAP1L2 Gene

MGI Knock Outs for NAP1L2:

Animal Model Products

CRISPR Products

miRNA for NAP1L2 Gene

miRTarBase miRNAs that target NAP1L2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAP1L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAP1L2 Gene

Localization for NAP1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with NAP1L2: view

Pathways & Interactions for NAP1L2 Gene

SuperPathways for NAP1L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS,IEA --
GO:0035066 positive regulation of histone acetylation IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
GO:0071442 positive regulation of histone H3-K14 acetylation IEA --
GO:2000035 regulation of stem cell division IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L2 Gene

Drugs & Compounds for NAP1L2 Gene

No Compound Related Data Available

Transcripts for NAP1L2 Gene

mRNA/cDNA for NAP1L2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L2 Gene

Nucleosome assembly protein 1-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAP1L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L2 Gene

No ASD Table

Relevant External Links for NAP1L2 Gene

GeneLoc Exon Structure for
NAP1L2
ECgene alternative splicing isoforms for
NAP1L2

Expression for NAP1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.4), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for NAP1L2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAP1L2 Gene



Protein tissue co-expression partners for NAP1L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L2 Gene:

NAP1L2

SOURCE GeneReport for Unigene cluster for NAP1L2 Gene:

Hs.66180

Evidence on tissue expression from TISSUES for NAP1L2 Gene

  • Nervous system(4.9)
  • Kidney(4.2)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with NAP1L2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L2 Gene

Orthologs for NAP1L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAP1L2 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia NAP1L2 33 34
  • 89.67 (n)
rat
(Rattus norvegicus)
Mammalia Nap1l2 33
  • 84.71 (n)
mouse
(Mus musculus)
Mammalia Nap1l2 33 16 34
  • 84.53 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nap1l1 34
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nap1 34
  • 33 (a)
ManyToMany
CG5017 34
  • 32 (a)
ManyToMany
CG3708 34
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nap-1 34
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 34
  • 35 (a)
OneToMany
Species where no ortholog for NAP1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAP1L2 Gene

ENSEMBL:
Gene Tree for NAP1L2 (if available)
TreeFam:
Gene Tree for NAP1L2 (if available)

Paralogs for NAP1L2 Gene

Paralogs for NAP1L2 Gene

(4) SIMAP similar genes for NAP1L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NAP1L2: view

Variants for NAP1L2 Gene

Sequence variations from dbSNP and Humsavar for NAP1L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs34995284 Uncertain significance 73,213,985(-) ATAAA(C/T)CAGAC reference, missense
rs1000794539 -- 73,212,643(+) GCATC(C/G/T)AAGTT utr-variant-3-prime
rs1000899772 -- 73,213,249(+) GCTGA(G/T)ATTCC reference, missense
rs1001098442 -- 73,212,079(+) GAAAG(G/T)TATAC downstream-variant-500B
rs1001984002 -- 73,212,799(+) AACAA(A/G/T)TATTG utr-variant-3-prime

Variation tolerance for NAP1L2 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAP1L2 Gene

Human Gene Mutation Database (HGMD)
NAP1L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAP1L2 Gene

Disorders for NAP1L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAP1L2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • anencephaly
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NAP1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAP1L2
genes like me logo Genes that share disorders with NAP1L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L2 Gene

Publications for NAP1L2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Control of neurulation by the nucleosome assembly protein-1-like 2. (PMID: 10932189) Rogner UC … Avner P (Nature genetics 2000) 3 22 60
  3. Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. (PMID: 8789438) Rougeulle C … Avner P (Human molecular genetics 1996) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Identification of candidate genes in atopic dermatitis based on bioinformatic methods. (PMID: 26967585) Ding Y … Fang H (International journal of dermatology 2016) 3 60

Products for NAP1L2 Gene

Sources for NAP1L2 Gene

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