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NAP1L1 Gene

protein-coding   GIFtS: 57
GCID: GC12M076438

Nucleosome Assembly Protein 1-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleosome Assembly Protein 1-Like 11 2     NAP1L2 5
NRP2 3     NAP12
hNRP2 3     HSP22-Like Protein Interacting Protein2
NAP-1-Related Protein2 3     NAP-1 Related Protein2

External Ids:    HGNC: 76371   Entrez Gene: 46732   Ensembl: ENSG000001871097   OMIM: 1640605   UniProtKB: P552093   

Export aliases for NAP1L1 gene to outside databases

Previous GC identifers: GC12M073514 GC12P075989 GC12M076156 GC12M074726


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAP1L1 Gene:
This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA
replication and may play a role in modulating chromatin formation and contribute to the regulation of cell
proliferation. Alternative splicing of this gene results in several transcript variants; however, not all have
been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAP1L1 Gene:
NAP1L1 (nucleosome assembly protein 1-like 1) is a protein-coding gene. Diseases associated with NAP1L1 include emery-dreifuss muscular dystrophy, and treacher collins syndrome. An important paralog of this gene is NAP1L3.

UniProtKB/Swiss-Prot: NP1L1_HUMAN, P55209
Function: May be involved in modulating chromatin formation and contribute to regulation of cell proliferation

Gene Wiki entry for NAP1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAP1L1 gene promoter:
         E2F-4   E2F-3a   E2F-5   p300   E2F-2   AP-4   YY1   GATA-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAP1L1 promoter sequence
   Search Chromatin IP Primers for NAP1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAP1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.2   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q21.1

NAP1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAP1L1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M076438:  view genomic region     (about GC identifiers)

Start:
76,438,670 bp from pter      End:
76,478,813 bp from pter
Size:
40,144 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NP1L1_HUMAN, P55209 (See protein sequence)
Recommended Name: Nucleosome assembly protein 1-like 1 precursor  
Size: 391 amino acids; 45374 Da
Secondary accessions: B3KNT8
Alternative splicing: 2 isoforms:  P55209-1   P55209-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NAP1L1: NX_P55209

Explore proteomics data for NAP1L1 at MOPED

Post-translational modifications: 

  • Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in
    polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated
    due to the absence of functional TTLL10 in human (By similarity)1
  • Ubiquitination2 at Lys32, Lys82, Lys87, Lys105, Lys116, Lys165
  • Modification sites at PhosphoSitePlus

  • See NAP1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004528.1  NP_631946.1  

    ENSEMBL proteins: 
     ENSP00000261182   ENSP00000450236   ENSP00000376947   ENSP00000409795   ENSP00000446804  
     ENSP00000448167   ENSP00000437507   ENSP00000444759   ENSP00000445008   ENSP00000447793  
     ENSP00000448007   ENSP00000447196   ENSP00000446520   ENSP00000449649   ENSP00000448133  
     ENSP00000448764   ENSP00000446787   ENSP00000448836   ENSP00000446756   ENSP00000448661  
     ENSP00000449333  

    NAP1L1 Human Recombinant Protein Products:

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    Novus Biologicals NAP1L1 Proteins
    Novus Biologicals NAP1L1 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NAP1L1
    Cloud-Clone Corp. Proteins for NAP1L1

    NAP1L1 Antibody Products:

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    Cloud-Clone Corp. CLIAs for NAP1L1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry P55209

    ProtoNet protein and cluster: P55209

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: NP1L1_HUMAN, P55209
    Domain: The acidic domains are probably involved in the interaction with histones
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    NAP1L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NP1L1_HUMAN, P55209
    Function: May be involved in modulating chromatin formation and contribute to regulation of cell proliferation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11940655
    GO:0044822poly(A) RNA binding IDA--
         
    NAP1L1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NAP1L1:
     Decreased viability after Chla 

         1 MGI phenotypic allele for Nap1l1 (no phenotypes)

    NAP1L1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAP1L1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAP1L1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAP1L1

    miRNA
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    miRTarBase miRNAs that target NAP1L1:
    hsa-mir-10a-5p (MIRT047674), hsa-mir-10b-5p (MIRT047497), hsa-mir-877-3p (MIRT037066), hsa-mir-30a-3p (MIRT049917), hsa-mir-132-3p (MIRT021853), hsa-mir-30a-5p (MIRT028667), hsa-mir-20a-5p (MIRT050612), hsa-mir-17-5p (MIRT051035), hsa-mir-26b-5p (MIRT050052)

    Block miRNA regulation of human, mouse, rat NAP1L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAP1L1 (see all 97):
    hsa-miR-124* hsa-miR-548j hsa-miR-3146 hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidNAP1L1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NAP1L1

    Gene Editing
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    OriGene clones in human, mouse for NAP1L1 (see all 13)
    OriGene ORF clones in mouse, rat for NAP1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NAP1L1 (NM_004537)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAP1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAP1L1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NAP1L1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NP1L1_HUMAN, P55209: Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage
    I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0042470melanosome IEA--

    NAP1L1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAP1L1
    Interactions:

        Search GeneGlobe Interaction Network for NAP1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAP1L1 (P552091, 2, 3 ENSP000002611824) via UniProtKB, MINT, STRING, and/or I2D (see all 295)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TTLL10Q6ZVT01, 2, 3, ENSP000003685914EBI-356392,EBI-7844656 MINT-6493231 MINT-6493246 MINT-6493222 MINT-6493255 MINT-6493277 I2D: score=1 STRING: ENSP00000368591
    CSNK2BP678702, 3MINT-8253451 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253451 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253451 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253451 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication TAS8297347
    GO:0006334nucleosome assembly IEA--
    GO:0008284positive regulation of cell proliferation TAS8297347

    NAP1L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAP1L1 (NP1L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAP1L1 gene (2 alternative transcripts): 
    NM_004537.4  NM_139207.2  

    Unigene Cluster for NAP1L1:

    Nucleosome assembly protein 1-like 1
    Hs.524599  [show with all ESTs]
    Unigene Representative Sequence: NM_004537
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000261182(uc001sxw.2 uc001sxx.2 uc010sty.1 uc001sxz.2 uc010stz.1 uc010sua.1 uc001syb.3)
    ENST00000552056 ENST00000393263 ENST00000431879 ENST00000552147 ENST00000547773
    ENST00000552013 ENST00000544816 ENST00000542344 ENST00000535020 ENST00000549596
    ENST00000547993 ENST00000547969 ENST00000552342 ENST00000547529 ENST00000548044
    ENST00000550934 ENST00000551992
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAP1L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAP1L1 (see all 97):
    hsa-miR-124* hsa-miR-548j hsa-miR-3146 hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidNAP1L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAP1L1
    Predesigned siRNA for gene silencing in human, mouse, rat NAP1L1
    Clone
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    OriGene clones in human, mouse for NAP1L1 (see all 13)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NAP1L1 (NM_004537)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAP1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAP1L1
    Primer
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    OriGene qPCR primer pairs and template standards for NAP1L1
    OriGene qSTAR qPCR primer pairs in human, mouse for NAP1L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAP1L1
      QuantiTect SYBR Green Assays in human, mouse, rat NAP1L1
      QuantiFast Probe-based Assays in human, mouse, rat NAP1L1

    Additional mRNA sequence: 

    AF086080.1 AK021751.1 AK122670.1 AK295147.1 AK297500.1 AK298936.1 AK304787.1 AL162068.1 
    BC002387.2 BC141946.1 BT007023.1 D28430.1 M86667.1 

    Selected DOTS entries (see all 98):

    DT.95370575  DT.86998877  DT.97868590  DT.100698900  DT.92325026  DT.121178617  DT.99953720  DT.75168697 
    DT.100698902  DT.95370610  DT.100698923  DT.100698892  DT.100698889  DT.100698906  DT.100045864  DT.40292868 
    DT.95370818  DT.100698899  DT.91748847  DT.121178656  DT.121178652  DT.91781259  DT.91781090  DT.95370712 

    Selected AceView cDNA sequences (see all 1688):

    CB134832 BI093838 BE328545 BM972006 CB052325 AI498236 BG058707 AI926158 
    CB133058 CR611076 AI357670 CB140099 BU608960 AA665466 AA576873 BE748880 
    BE503071 BQ025974 BM479891 BG286242 BF970434 BQ009602 AA730326 BM970567 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L1 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
    SP1:                                                        -                       -     -     -     -                                                         
    SP2:                          -                             -                       -     -     -     -                                                         
    SP3:                          -                             -                       -     -     -     -                                                         
    SP4:                          -                             -                             -     -     -                                                         
    SP5:                          -                             -                 -     -     -     -                                                               

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for NAP1L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAP1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGACATA
    NAP1L1 Expression
    About this image


    NAP1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
    NAP1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAP1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524599

    UniProtKB/Swiss-Prot: NP1L1_HUMAN, P55209
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAP1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAP1L1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nap1l11 , 5 nucleosome assembly protein 1-like 11, 5 93.27(n)1
    98.21(a)1
      10 (58.67 cM)5
    536051  NM_015781.41  NP_056596.11 
     1114731925 
    chicken
    (Gallus gallus)
    Aves NAP1L11 nucleosome assembly protein 1-like 1 85.85(n)
    90.54(a)
      417864  XM_416106.4  XP_416106.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    85(a)
    1 → many
    5(40559945-40619366)
    African clawed frog
    (Xenopus laevis)
    Amphibia nap1l1-prov2 nucleosome assembly protein 1-like 1 84.5(n)    BC043903.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nap1l12 nucleosome assembly protein 1, like 1 77.01(n)   368260  BC044152.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nap11 , 3 nucleosome assembly histone-specific
    chaperone3
    Nucleosome assembly protein 11
    47(a)
    (best of 2)3
    53.41(n)1
    55.11(a)1
      60A93
    377981  NM_001259556.11  NP_001246485.11 
    worm
    (Caenorhabditis elegans)
    Secernentea D2096.83   -- 41(a)   IV(8378271-8379497)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAP11 NAP1 50(n)
    38.01(a)
      853922   NP_012974.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NAP1;11 NAP1;1 52.93(n)
    44.19(a)
      828717  NM_118744.2  NP_194341.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05397001 Os05g0539700 51.53(n)
    42.86(a)
      4339460  NM_001062710.1  NP_001056175.1 


    ENSEMBL Gene Tree for NAP1L1 (if available)
    TreeFam Gene Tree for NAP1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAP1L1 gene
    NAP1L32  NAP1L62  NAP1L22  NAP1L42  
    4 SIMAP similar genes for NAP1L1 using alignment to 19 protein entries:     NP1L1_HUMAN (see all proteins):
    NAP1L6    NAP1L4    NAP1L2    NAP1L3

    NAP1L1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for NAP1L1
    PGOHUM00000261126 PGOHUM00000239403 PGOHUM00000258722 PGOHUM00000238149 PGOHUM00000261822


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAP1L1 (see all 827)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819773251,2
    --76438218(+) TCCCAC/TAGGAA 2 -- ds50010--------
    rs753154961,2
    C,F--76438261(+) AGTAAT/CCTATT 2 -- ds50012Minor allele frequency- C:0.04WA NA 238
    rs751084371,2
    F--76438263(+) TAATCT/CATTAT 2 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1436915641,2
    --76438301(+) TCAGAA/CTCTTG 2 -- ds50010--------
    rs1862071731,2
    --76438774(+) ACCATC/TACCAT 2 -- ut310--------
    rs788291071,2
    C,F--76438891(+) ATATAT/CGTACA 2 -- ut311Minor allele frequency- C:0.02EA 120
    rs1916585201,2
    --76438895(+) ATGTAC/TAGTGC 2 -- ut310--------
    rs1835486311,2
    --76438900(+) CAGTGC/TAGATT 2 -- ut310--------
    rs1863480281,2
    --76438906(+) AGATTA/TAAAAA 2 -- ut310--------
    rs1912552441,2
    --76439040(+) AAGGCC/TTAAAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NAP1L1 (76438670 - 76478813 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NAP1L1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAP1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for NAP1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164060    OMIM disorders: --

    13 diseases for NAP1L1:    
    About MalaCards
    emery-dreifuss muscular dystrophy    treacher collins syndrome    muscular dystrophy    malaria
    hepatitis c virus    hepatitis c    hiv-1    cervicitis
    ovarian cancer    obesity    neuroblastoma    hepatitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for NAP1L1:
    Emery-Dreifuss muscular dystrophy

    NAP1L1 for disorders           About GeneDecksing


    Export disorders for NAP1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAP1L1 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with NAP1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. (PubMed id 8297347)1, 2, 3 Simon H.-U....Siminovitch K.A. (Biochem. J. 1994)
    2. The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription. (PubMed id 18226242)1, 2 Vardabasso C.... Giacca M. (Retrovirology 2008)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)1, 2 Kho Y.... Zhao Y. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The nucleosome assembly activity of NAP1 is enhanced by Alien. (PubMed id 17339334)1, 9 Eckey M....Baniahmad A. (Mol. Cell. Biol. 2007)
    10. Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. (PubMed id 20002496)1, 9 Okuwaki M....Nagata K. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4673 HGNC: 7637 AceView: NAP1L1 Ensembl:ENSG00000187109 euGenes: HUgn4673
    ECgene: NAP1L1 H-InvDB: NAP1L1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAP1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAP1L1 gene:
    Search GeneIP for patents involving NAP1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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