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Aliases for NAP1L1 Gene

Aliases for NAP1L1 Gene

  • Nucleosome Assembly Protein 1 Like 1 2 3 5
  • Nucleosome Assembly Protein 1-Like 1 2 3
  • NAP-1-Related Protein 3 4
  • NRP 3 4
  • HSP22-Like Protein Interacting Protein 3
  • NAP1L 3
  • NAP1 3
  • HNRP 4

External Ids for NAP1L1 Gene

Previous GeneCards Identifiers for NAP1L1 Gene

  • GC12M073514
  • GC12P075989
  • GC12M076156
  • GC12M074726
  • GC12M076438

Summaries for NAP1L1 Gene

Entrez Gene Summary for NAP1L1 Gene

  • This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

GeneCards Summary for NAP1L1 Gene

NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NAP1L1 include Antenatal Bartter Syndrome. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is NAP1L4.

UniProtKB/Swiss-Prot for NAP1L1 Gene

  • May be involved in modulating chromatin formation and contribute to regulation of cell proliferation.

Gene Wiki entry for NAP1L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L1 Gene

Genomics for NAP1L1 Gene

Regulatory Elements for NAP1L1 Gene

Enhancers for NAP1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G075974 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +105.9 105916 10.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000258077 PHLDA1 NAP1L1 ENSG00000251893 GLIPR1 LOC100289143
GH12G076151 0.7 Ensembl 11.3 -67.3 -67268 1.0 ZNF133 MAFG ZNF316 CBX5 EED IKZF1 ETV6 IKZF2 MAFK EMSY NAP1L1 BBS10 ENSG00000251893 GC12P076140 LINC02407
GH12G075861 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +221.5 221456 4.1 FOXA2 JUN CEBPG FOSL1 CTBP1 GATA2 FOSL2 FOS MAFK ZNF3 PHLDA1 ENSG00000251893 NAP1L1 ENSG00000258091 LOC105369846
GH12G076124 0.6 Ensembl 11.9 -39.5 -39468 0.2 SMARCA5 FOSL1 MCM3 MTA2 MTA1 EGR1 IKZF1 NAP1L1 ENSG00000258304 LOC641695
GH12G076274 1.3 Ensembl ENCODE dbSUPER 4.7 -191.9 -191855 5.6 ATF1 JUN MAX CEBPG RAD21 YY1 FOSL1 ZNF766 GATA2 SCRT2 LINC02407 NAP1L1 GC12M076305
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAP1L1 on UCSC Golden Path with GeneCards custom track

Promoters for NAP1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054131 633 2401 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for NAP1L1 Gene

Chromosome:
12
Start:
76,036,587 bp from pter
End:
76,085,033 bp from pter
Size:
48,447 bases
Orientation:
Minus strand

Genomic View for NAP1L1 Gene

Genes around NAP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L1 Gene

Proteins for NAP1L1 Gene

  • Protein details for NAP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55209-NP1L1_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 1
    Protein Accession:
    P55209
    Secondary Accessions:
    • B3KNT8
    • B3KV44

    Protein attributes for NAP1L1 Gene

    Size:
    391 amino acids
    Molecular mass:
    45374 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAP1L1 Gene

Post-translational modifications for NAP1L1 Gene

  • Monoglycylated on glutamate residues. Cannot be polyglycylated due to the absence of functional TTLL10 in human (By similarity).
  • Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and monoglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
  • Ubiquitination at Lys32, posLast=8282, posLast=8787, Lys105, and posLast=165165
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NAP1L1
  • Cloud-Clone Corp. Antibodies for NAP1L1

No data available for DME Specific Peptides for NAP1L1 Gene

Domains & Families for NAP1L1 Gene

Protein Domains for NAP1L1 Gene

Graphical View of Domain Structure for InterPro Entry

P55209

UniProtKB/Swiss-Prot:

NP1L1_HUMAN :
  • The acidic domains are probably involved in the interaction with histones.
  • Belongs to the nucleosome assembly protein (NAP) family.
Domain:
  • The acidic domains are probably involved in the interaction with histones.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L1: view

No data available for Gene Families for NAP1L1 Gene

Function for NAP1L1 Gene

Molecular function for NAP1L1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in modulating chromatin formation and contribute to regulation of cell proliferation.

Gene Ontology (GO) - Molecular Function for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 11940655
genes like me logo Genes that share ontologies with NAP1L1: view
genes like me logo Genes that share phenotypes with NAP1L1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAP1L1

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L1 Gene

Localization for NAP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L1 Gene

Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA 19946888
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with NAP1L1: view

Pathways & Interactions for NAP1L1 Gene

SuperPathways for NAP1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication TAS 8297347
GO:0006334 nucleosome assembly IEA,TAS --
GO:0008284 positive regulation of cell proliferation TAS 8297347
genes like me logo Genes that share ontologies with NAP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L1 Gene

Transcripts for NAP1L1 Gene

Unigene Clusters for NAP1L1 Gene

Nucleosome assembly protein 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: -
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15:
SP16:
SP17:
SP18: - - - - - - -
SP19:
SP20:
SP21:
SP22:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17: - - -
SP18:
SP19: - -
SP20: -
SP21:
SP22:

Relevant External Links for NAP1L1 Gene

GeneLoc Exon Structure for
NAP1L1
ECgene alternative splicing isoforms for
NAP1L1

Expression for NAP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAP1L1 Gene

This gene is overexpressed in Bone marrow stromal cell (11.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAP1L1 Gene



Protein tissue co-expression partners for NAP1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L1 Gene:

NAP1L1

SOURCE GeneReport for Unigene cluster for NAP1L1 Gene:

Hs.524599

mRNA Expression by UniProt/SwissProt for NAP1L1 Gene:

P55209-NP1L1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for NAP1L1 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Lung(4.5)
  • Muscle(4.5)
  • Eye(4.4)
  • Intestine(4.4)
  • Kidney(4.2)
  • Skin(4.1)
  • Pancreas(3.9)
  • Blood(3.2)
  • Bone(3.1)
  • Stomach(2.6)
  • Heart(2.4)
  • Lymph node(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.2)
  • Bone marrow(2.1)
  • Gall bladder(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NAP1L1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L1 Gene

Orthologs for NAP1L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAP1L1 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia NAP1L1 34 35
  • 96.42 (n)
cow
(Bos Taurus)
Mammalia NAP1L1 34 35
  • 96.16 (n)
-- 35
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nap1l1 34
  • 94.46 (n)
mouse
(Mus musculus)
Mammalia Nap1l1 34 16 35
  • 93.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
ManyToMany
-- 35
  • 89 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 92 (a)
OneToMany
NAP1L1 34
  • 85.85 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nap1l1 34
  • 80.82 (n)
Str.10809 34
African clawed frog
(Xenopus laevis)
Amphibia nap1l1-prov 34
zebrafish
(Danio rerio)
Actinopterygii nap1l1 34 35
  • 75.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001928 34
  • 53.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nap1 36 34 35
  • 53.41 (n)
EG:BACR7A4.18 36
  • 35 (a)
CG5017 35
  • 35 (a)
ManyToMany
CG3708 35
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nap-1 35
  • 43 (a)
OneToMany
D2096.8 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 34 35
  • 50 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15049g 34
  • 49.06 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL109W 34
  • 45.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NAP1;1 34
  • 52.93 (n)
rice
(Oryza sativa)
Liliopsida Os05g0539700 34
  • 51.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 35
  • 58 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nap1 34
  • 48.94 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01438 34
  • 48.29 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12175 34
Species where no ortholog for NAP1L1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAP1L1 Gene

ENSEMBL:
Gene Tree for NAP1L1 (if available)
TreeFam:
Gene Tree for NAP1L1 (if available)

Paralogs for NAP1L1 Gene

Variants for NAP1L1 Gene

Sequence variations from dbSNP and Humsavar for NAP1L1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000025562 -- 76,084,334(+) CCTAC(A/G)TCGCC intron-variant, upstream-variant-2KB
rs1000030196 -- 76,048,274(+) AGGTA(A/G)AACAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000048849 -- 76,053,087(+) TCAAC(G/T)TACCA intron-variant
rs1000133232 -- 76,061,492(+) CGTGG(C/T)GTATA intron-variant
rs1000177672 -- 76,066,219(+) ACAAA(C/G)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAP1L1 Gene

Variant ID Type Subtype PubMed ID
nsv474068 CNV novel sequence insertion 20440878
nsv474137 CNV novel sequence insertion 20440878
nsv474261 CNV novel sequence insertion 20440878
nsv474626 CNV novel sequence insertion 20440878
nsv477998 CNV novel sequence insertion 20440878
nsv478113 CNV novel sequence insertion 20440878
nsv479685 CNV novel sequence insertion 20440878
nsv479829 CNV novel sequence insertion 20440878
nsv480601 CNV novel sequence insertion 20440878
nsv480625 CNV novel sequence insertion 20440878
nsv481078 CNV novel sequence insertion 20440878
nsv481434 CNV novel sequence insertion 20440878
nsv559423 CNV loss 21841781
nsv973093 CNV duplication 23825009

Variation tolerance for NAP1L1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L1 Gene

Disorders for NAP1L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAP1L1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
antenatal bartter syndrome
  • hyperprostaglandin e syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NAP1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAP1L1
genes like me logo Genes that share disorders with NAP1L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L1 Gene

Publications for NAP1L1 Gene

  1. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. (PMID: 8297347) Simon H.-U. … Siminovitch K.A. (Biochem. J. 1994) 2 3 4 64
  2. Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. (PMID: 20002496) Okuwaki M. … Nagata K. (Genes Cells 2010) 3 22 64
  3. The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription. (PMID: 18226242) Vardabasso C. … Giacca M. (Retrovirology 2008) 3 4 64
  4. The nucleosome assembly activity of NAP1 is enhanced by Alien. (PMID: 17339334) Eckey M. … Baniahmad A. (Mol. Cell. Biol. 2007) 3 22 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for NAP1L1 Gene

Sources for NAP1L1 Gene

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