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NANS Gene

protein-coding GIFtS: 59

GC09P099858

N-acetylneuraminic acid synthase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.5.1.56,EC 2.5.1.57 ^³
OTTHUMP00000021769 ^²
SAS ^¹, ², ³, ⁵

Descriptions
N-acetylneuraminate synthase ^³
N-acetylneuraminate-9-phosphate synthase ^³
N-acetylneuraminic acid phosphate synthase ^², ³
N-acetylneuraminic acid synthase ^², ³
sialic acid phosphate synthase ^²
sialic acid synthase ^²

External Ids
HGNC: 19237¹
Entrez Gene: 54187²
UniProtKB: Q9NR45³
Ensembl: ENSG00000095380⁷

Search outside databases for aliases for NANS gene

Previous GC identifers: GC09P092562 GC09P094276 GC09P096198 GC09P097898

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NANS:

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro,

the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to

generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and

2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much

higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene

results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase

gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative

mutant. [provided by RefSeq]

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45

Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic

acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to

generate phosphorylated forms of Neu5Ac and KDN, respectively

Gene Wiki entry for NANS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NANS gene

Entrez Gene cytogenetic band: 9p24.1-p23 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9p24.1-p23

NANS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P099858: (about GC identifiers)

Start:	99,858,842 bp from pter
End:	99,885,178 bp from pter
Size:	26,337 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45 (See protein sequence)

Recommended Name: Sialic acid synthase

Size: 359 amino acids; 40308 Da

PDB structures from and Proteopedia :

1WVO (3D)

Secondary accessions: Q8WUV9 Q9BWS6 Q9NVD4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_061819.2

ENSEMBL proteins:

ENSP00000210444

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NANS)
	Human Recombinant Proteins from Abnova (NANS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	10749855
GO:0005829	cytosol	IEA	--

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Antibodies for NANS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NANS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NANS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NANS)
	Novus Biologicals Antibodies for NANS

Assays for NANS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NR45

ProtoNet protein and cluster: Q9NR45

2 Blocks protein families:

IPB006013 Type III antifreeze protein signature

IPB013132 N-acetylneuraminic acid synthase

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45

Similarity: Contains 1 AFP-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NANS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NANS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018946

Applied Biosystems Silencer® siRNAs for NANS

Sigma-Aldrich siRNA for NANS

Sigma-Aldrich shRNA for NANS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NANS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018946
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018946
untagged cDNA clone in CMV expression vector: NM_018946

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018946

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45

Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic

acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to

generate phosphorylated forms of Neu5Ac and KDN, respectively

Catalytic activity: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate +

N-acetylneuraminate

Catalytic activity: Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O =

N-acylneuraminate 9-phosphate + phosphate

Enzyme Number (IUBMB): EC 2.5.1.56,EC

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008781	N-acylneuraminate cytidylyltransferase activity	NAS	10749855
GO:0016740	transferase activity	IEA	--
GO:0019007	N-acetylneuraminic acid phosphate synthase activity	IEA	--
GO:0047444	N-acylneuraminate-9-phosphate synthase activity	IEA	--
GO:0050462	N-acetylneuraminate synthase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for NANS (Your Favorite Gene powered by Ingenuity)

Aminosugars Metabolism

GeneDecks NANS for the pathways selected above

About GeneDecksing

5/11 Interacting proteins for NANS (Q9NR45² ENSP00000210444³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSP90AB1	P08238²	MINT-72658
CMAS	ENSP00000229329³	STRING (score=.995)
GNE	ENSP00000340770³	STRING (score=.985)
ENSG00000107902	ENSP00000357835³	STRING (score=.899)
MTMR1	ENSP00000359417³	STRING (score=.899)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--
GO:0009103	lipopolysaccharide biosynthetic process	NAS	10749855
GO:0016051	carbohydrate biosynthetic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NANS
4 Novoseek chemical compound relationships for NANS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-keto-3-deoxy-d-glycero-d-galacto-nononic acid	94.39	1	10749855 (1)
sialic acid	81.36	28	16729195 (4), 16274664 (2), 16597820 (2), 14690432 (2) (see all 11)
phosphoenolpyruvate	53.10	1	15888312 (1)
n-acetylglucosamine	50.48	1	14690432 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NANS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NANS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018946

Sigma-Aldrich siRNA for NANS

Sigma-Aldrich shRNA for NANS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018946

REFSEQ mRNAs for NANS gene:

NM_018946.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018946

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018946
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018946
                                 untagged cDNA clone in CMV expression vector: NM_018946

Additional cDNA sequence:

AF257466.1 AK001659.1 AK316608.1 BC000008.2 BC019315.1 CR593110.1 CR600247.1 CR602868.1

CR608894.1 CR618616.1 CR624153.1

17 DOTS entries:

DT.75138517 DT.100037659 DT.97860866 DT.99935837 DT.40129122 DT.40241205 DT.99986371 DT.100037657

DT.100037658 DT.121164961 DT.121165009 DT.121165015 DT.92435154 DT.95258334 DT.97860871 DT.121164954

DT.95258404

24/267 AceView cDNA sequences (see all 267 ):

CR624153 BU687286 BM563430 BU727751 CD671274 AW245927 CA434954 BF437450

BQ773353 CA417480 BQ649507 BQ018989 BM069645 AW249532 AA057865 BM976474

AA602087 BU618375 BQ440854 CB116856 CF529131 CR608894 AL526281 CR602868

highest scoring ESTs for NANS:

AA056990 AA057158 AA064652 AA132974 AA195380 AA564277 AA568252 AA602067 AA602087 AA621146

Unigene Cluster for NANS:

N-acetylneuraminic acid synthase

Hs.522310 [show with all ESTs]

Unigene Representative Sequence: CR624153

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NANS (see all 9 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10
SP1:							-		-		-		-		-		-				-
SP2:							-		-		-				-		-				-
SP3:															-		-
SP4:
SP5:																													-

About this scheme

ECgene alternative splicing isoforms for NANS

1 Ensembl transcript including schematic representation:

ENST00000210444

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NANS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NANS

¹ / ² / ³

2 probe-sets matching NANS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
218189_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_018946	0.60	1.00	0.82	1
218189_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAAGCACTC

SOURCE GeneReport for Unigene cluster: Hs.522310
Expression variation in blood from EXPOLDB for NANS
UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NANS gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NANS¹	--	N-acetylneuraminic acid synthase	92.48(n) 95.82(a)	481624 XM_538746.2 XP_538746.2
chimpanzee (Pan troglodytes)	NANS¹	--	N-acetylneuraminic acid synthase	99.63(n) 100(a)	743934 XM_001157918.1 XP_001157918.1
cow (Bos taurus)	NANS¹	--	N-acetylneuraminic acid synthase	92.2(n) 96.66(a)	540602 NM_001046482.1 NP_001039947.1
rat (Rattus norvegicus)	Nans¹	--	N-acetylneuraminic acid synthase	89.42(n) 94.99(a)	298071 XM_216398.4 XP_216398.3
mouse (Mus musculus)	Nans^{1, 5}	4⁵	N-acetylneuraminic acid synthase (sialic acid synthase)^{1, 5}	88.77(n)¹ 94.71(a)¹	94181¹ NM_053179.3¹ NP_444409.1¹ AB041263⁵ AK076290⁵ (see all 16)

About this table Species with no ortholog for NANS

ENSEMBL Gene Tree for NANS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in NANS are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 33)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3199064^1,2	A,C,F,H	99858891(+)	`GAGGCG/TTTGGA`	1	--	ut5¹		12		EU EA WA NA	1052
	rs6478539^1,2	A,C,F,H	99858541(+)	`ATAGAC/TTATGC`	1	--	ng5¹		4		EU EA WA	416
--	rs6478537^1,2	C,F,H	99858165(+)	`GAGCCC/Tggggc`	1	--	ng5¹ tfbs³		4		EU EA WA	412
	rs1058446^1,2	C,F,H	99862956(+)	`TTGGAG/CAGGCC`	1	D/E	mis¹		10		MN EU EA WA NA	1066
--	rs7855984^1,2	A,C	99858111(+)	`gtgctA/Gggatt`	1	--	ng5¹		0	--	--	--	--
	rs13049^1,2	C,F,H	99862905(+)	`TGTGCC/TAAGTT`	1	A/A	syn¹		8		NA EU EA WA	588
	rs3739670^1,2	A,C,F	99859013(-)	`GCTACG/ATCCAG`	1	D/D	syn¹		4		MN NA	324
	rs10818454^1,2	A,C,F,H	99859761(+)	`tgCGTG/ACTCCC`	1	--	int¹		12		EU EA WA NA	1044
	rs9969813^1,2	A,C,F,H	99861445(+)	`AATAGC/GATGAA`	1	--	int¹		8		EU EA WA	838
	rs4743158^1,2	A,C,F,H	99861096(+)	`AGTGAT/CCTCAG`	1	--	int¹		7		EU EA WA NA	558

About this table

HapMap Linkage Disequilibrium images for NANS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605202

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/20 PubMed articles for NANS gene (see all 20 ):

Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. (PubMed id 10749855)^{1, 2, 3, 4} Lawrence S.M.... Betenbaugh M.J. (2000)
Solution structure of the antifreeze-like domain of human sialic acid synthase. (PubMed id 16597820)^{1, 3, 4} Hamada T....Hirota H. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Cloning, expression, and characterization of sialic acid synthases. (PubMed id 16274664)^{1, 3} Hao J....Sundaramoorthy M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity. (PubMed id 10873658)³ Nakata D....Kitajima K. (2000)
Event-related slow brain potentials, cognitive processes, and alexithymia. (PubMed id 693772)³ Lolas F. (1978)
Manifold decrease of sialic acid synthase in fetal Down syndrome brain. (PubMed id 16729195)¹ Gulesserian T....Lubec G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54187	HGNC: 19237	AceView: NANS	Ensembl:ENSG00000095380	euGenes: HUgn54187
ECgene: NANS	H-InvDB: NANS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NANS	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NANS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NANS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NANS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NANS		Antibodies for NANS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NANS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NANS)
	Antibodies (NANS)
	Chimera RNAi (NANS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (NANS)
	Antibodies (NANS)

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Search Tocris compounds for NANS

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Antibodies for NANS

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NANS Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for NANS

Summaries
for NANS

Genomic Location
for NANS

Proteins
for NANS

Protein Domains/
Families
for NANS

Gene Function
for NANS

Pathways & Interactions
for NANS

Drugs & Compounds
for NANS

Transcripts
for NANS

Expression
for NANS

Orthologs
for NANS

Paralogs
for NANS

SNPs/Variants
for NANS

Disorders & Mutations
for NANS

Medical News
for NANS

Publications
for NANS

Search for NANS

Genome Databases showing NANS

Other Databases showing NANS

Specialized Databases showing NANS

Licensable Technologies
for NANS

Services
for NANS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NANS Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor NANS

Summariesfor NANS

Genomic Locationfor NANS

Proteinsfor NANS

Protein Domains/Familiesfor NANS

Gene Functionfor NANS

Pathways & Interactionsfor NANS

Drugs & Compoundsfor NANS

Transcriptsfor NANS

Expression for NANS

Orthologsfor NANS

Paralogsfor NANS

SNPs/Variantsfor NANS

Disorders & Mutationsfor NANS

Medical Newsfor NANS

Publicationsfor NANS

Search for NANS

Genome Databases showing NANS

Other Databases showing NANS

Specialized Databases showing NANS

Licensable Technologiesfor NANS

Servicesfor NANS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NANS

Summaries
for NANS

Genomic Location
for NANS

Proteins
for NANS

Protein Domains/
Families
for NANS

Gene Function
for NANS

Pathways & Interactions
for NANS

Drugs & Compounds
for NANS

Transcripts
for NANS

Expression
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