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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NANS Gene

protein-coding   GIFtS: 59
GCID: GC09P100818

N-acetylneuraminic acid synthase

 Explore 4 diseases affiliated with
NANS via our new
 Human Malady Compendium 
Biological research products
for NANS
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
N-Acetylneuraminic Acid Synthase1 2 3     Sialic Acid Phosphate Synthase2
SAS1 2 3 5     Sialic Acid Synthase2
N-Acetylneuraminate Synthase2 3     EC 2.5.1.563
N-Acetylneuraminate-9-Phosphate Synthase2 3     EC 2.5.1.573
N-Acetylneuraminic Acid Phosphate Synthase2 3     

External Ids:    HGNC: 192371   Entrez Gene: 541872   Ensembl: ENSG000000953807   OMIM: 6052025   UniProtKB: Q9NR453   

Export aliases for NANS gene to outside databases

Previous GC identifers: GC09P092562 GC09P094276 GC09P096198 GC09P097898 GC09P099858 GC09P070419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NANS:
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein
uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of
N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it
exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in
Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially
restore sialic acid synthase activity in an E. coli neuB-negative mutant. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also
use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac
and KDN, respectively

Gene Wiki entry for NANS


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NANS gene promoter:
         Egr-3   STAT5B   Pax-5   Egr-1   STAT5A   CUTL1   LCR-F1   Egr-2   IRF-7A   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANS promoter sequence
   Search SABiosciences Chromatin IP Primers for NANS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1-p23   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9p24.1-p23

NANS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100818:  view genomic region     (about GC identifiers)

Start:
100,818,959 bp from pter      End:
100,845,365 bp from pter
Size:
26,407 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45 (See protein sequence)
Recommended Name: Sialic acid synthase  
Size: 359 amino acids; 40308 Da
1 PDB 3D structure from and Proteopedia for NANS:
1WVO (3D)    
Secondary accessions: B2RE98 Q8WUV9 Q9BWS6 Q9NVD4

Explore the universe of human proteins at neXtProt for NANS: NX_Q9NR45

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NR45

  • NANS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061819.2  
    ENSEMBL proteins: 
     ENSP00000210444   ENSP00000404107   ENSP00000404642  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: NANS
    OriGene Protein Over-expression Lysate: NANS
    OriGene Custom Protein Services for NANS 
    GenScript Custom Purified and Recombinant Proteins Services for NANS
    Novus Biologicals NANS Proteins
    Novus Biologicals NANS Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NANS
    Uscn Proteins for NANS

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS10749855
    GO:0005829cytosol IEA--


    NANS for ontologies           About GeneDecksing



    NANS Antibody Products: 
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    Uscn Antibodies for NANS
    ThermoFisher Antibodies for NANS

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    Uscn ELISAs and CLIAs for NANS


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NANS for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR006190 AFP_Neu5c_C
     IPR013974 SAF
     IPR006013 Antifreeze_III
     IPR013132 Neu5Ac_N

    Graphical View of Domain Structure for InterPro Entry Q9NR45

    ProtoNet protein and cluster: Q9NR45

    2 Blocks protein families:
    IPB006013 Type III antifreeze protein signature
    IPB013132 N-acetylneuraminic acid synthase


    UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
    Similarity: Contains 1 AFP-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
    Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also
    use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac
    and KDN, respectively
    Catalytic activity: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate
    Catalytic activity: Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O = N-acylneuraminate 9-phosphate +
    phosphate

    Enzyme Numbers (IUBMB): EC 2.5.1.571 EC 2.5.1.561

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANS
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    OriGene shRNA RFP: NANS
    OriGene siRNA: NANS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANS

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANS 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANS

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008781N-acylneuraminate cytidylyltransferase activity NAS10749855
    GO:0047444N-acylneuraminate-9-phosphate synthase activity IEA--
    GO:0050462N-acetylneuraminate synthase activity IEA--


    NANS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NANS:
     Increased cell death HMECs cel 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism1.00
    2CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
    CMP-N-acetylneuraminate biosynthesis I (eukaryotes)1.00
    3Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NANS 
        CMP-N-acetylneuraminate biosynthesis I (eukaryotes)


    2         Kegg Pathways  (Kegg details for NANS):
        Amino sugar and nucleotide sugar metabolism
    Metabolic pathways


    NANS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NANS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/14 Interacting proteins for NANS (Q9NR452, 3 ENSP000002104444) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3MINT-72658 I2D: score=2 
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    DDA1Q9BW613, ENSP000003529284I2D: score=3 STRING: ENSP00000352928
    C12orf44Q9BSB43I2D: score=1 
    GOT1P171743I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009103lipopolysaccharide biosynthetic process NAS10749855
    GO:0016051carbohydrate biosynthetic process ----


    NANS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NANS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NANS

    8 HMDB Compounds for NANS    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetyl-D-mannosamine 6-phosphateManNAc-6-P (see all 6)873185-52-5--
    N-Acetylmannosamine2-Acetamido-2-deoxy-D-mannose (see all 3)3615-17-6--
    N-Acetylneuraminate 9-phosphate ----
    N-Acetylneuraminic acidSialic acid (see all 55)131-48-6--
    N-Acetylneuraminic acid 9-phosphateN-acetyl- 9-(dihydrogen phosphate)-Neuraminic acid (see all 3)37992-17-9--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoenolpyruvic acid2-hydroxy-Acrylic acid dihydrogen phosphate (see all 6)138-08-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    4 Novoseek chemical compound relationships for NANS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-keto-3-deoxy-d-glycero-d-galacto-nononic acid 94.2 1 10749855 (1)
    sialic acid 81.7 29 16729195 (4), 16274664 (2), 16597820 (2), 14690432 (2) (see all 12)
    phosphoenolpyruvate 51.5 1 15888312 (1)
    n-acetylglucosamine 49 1 14690432 (1)

    Search CenterWatch for drugs/clinical trials and news about NANS / SIAS 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NANS gene: 
    NM_018946.3  

    Unigene Cluster for NANS:

    N-acetylneuraminic acid synthase
    Hs.522310  [show with all ESTs]
    Unigene Representative Sequence: BQ706872
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000210444(uc004ayc.3) ENST00000495319 ENST00000480925 ENST00000461452
    ENST00000415280 ENST00000427646(uc004aye.1)

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANS

    Additional cDNA sequence: 

    AF257466.1 AK001659.1 AK316608.1 BC000008.2 BC019315.1 

    18 DOTS entries:

    DT.75138517  DT.100037659  DT.97860866  DT.99935837  DT.40129122  DT.40241205  DT.99986371  DT.100037657 
    DT.97860868  DT.100037658  DT.121164961  DT.121165009  DT.121165015  DT.92435154  DT.95258334  DT.97860871 
    DT.121164954  DT.95258404 

    24/267 AceView cDNA sequences (see all 267):

    CR624153 CR608894 CA417480 CR600247 AW249532 CD671274 AW004987 BU687286 
    BU171085 BQ773353 NM_018946 BM563430 BQ446501 CB127616 AL526281 CR602868 
    BU187658 BG746329 CB116856 AL522852 AA602087 BM976474 AA057865 BG746292 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NANS (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                    -     -     -     -     -     -           -                                       
    SP2:                    -     -     -           -     -           -                                       
    SP3:                                            -     -                                                   
    SP4:                                                                                                      
    SP5:                                                                                      -               


    ECgene alternative splicing isoforms for NANS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NANS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAAAAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NANS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NANS

    SOURCE GeneReport for Unigene cluster: Hs.522310

    UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NANS gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nans1 , 5 N-acetylneuraminic acid synthase (sialic acid synthase)1, 5 88.77(n)1
    94.71(a)1
      4 (24.83 cM)5
    941811  NM_053179.31  NP_444409.11 
     464892485 
    chicken
    (Gallus gallus)
    Aves NANS1 N-acetylneuraminic acid synthase 80.63(n)
    87.15(a)
      427283  NM_001007975.1  NP_001007976.1 
    lizard
    (Anolis carolinensis)
    Reptilia NANS6
    --
    85(a)
    1 ↔ 1
    GL343201.1(2372370-2387382)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124732 Xenopus laevis transcribed sequence with moderate similarity more 75.66(n)    CD301354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC050955.12   -- 77.69(n)    BC050955.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sas1 Sialic acid phosphate synthase 54.65(n)
    50.45(a)
      41528  NM_141938.1  NP_650195.1 


    ENSEMBL Gene Tree for NANS (if available)
    TreeFam Gene Tree for NANS (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 NCBI SNPs in NANS are shown (see all 203    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860233381,2
    --100817108(+) GCAATC/GCCGAA 1 -- us2k10--------
    rs126827851,2
    H--100817148(+) ggttcA/Cccatg 1 -- us2k10--------
    rs1897876291,2
    --100817152(+) CACCAG/TGCCCA 1 -- us2k10--------
    rs1813886181,2
    --100817289(+) TCAGAA/GGTTTT 1 -- us2k10--------
    rs1115541111,2
    --100817331(+) AGTTTC/TGCTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1404883301,2
    --100817595(+) TATGCC/TCCACC 1 -- us2k10--------
    rs1906591111,2
    --100817665(+) GTGCTA/GATTGG 1 -- us2k10--------
    rs1448991831,2
    --100817743(+) GGACAC/GAAGAT 1 -- us2k10--------
    rs1829135161,2
    --100817776(+) TGGTGC/GTGCCA 1 -- us2k10--------
    rs1860689401,2
    --100817790(+) GATCCA/GTCAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NANS (100818959 - 100845365 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NANS: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NANS for disorders           About GeneDecksing

    OMIM gene information: 605202    OMIM disorders: --

    4 diseases for NANS:    About MalaCards
    hard palate cancer    alexithymia    down syndrome    carcinoma

    3 diseases from the University of Copenhagen DISEASES database for NANS:
    Cleft lip     Cleft palate     Hard palate cancer
    Human Genome Epidemiology (HuGE) Navigator: NANS (1 document)

    Export disorders for NANS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NANS gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with NANS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. (PubMed id 10749855)1, 2, 3, 9 Lawrence S.M.... Betenbaugh M.J. (2000)
    2. Solution structure of the antifreeze-like domain of human sialic acid synthase. (PubMed id 16597820)1, 2, 9 Hamada T....Hirota H. (2006)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Cloning, expression, and characterization of sialic acid synthases. (PubMed id 16274664)1, 9 Hao J....Sundaramoorthy M. (2005)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54187 HGNC: 19237 AceView: NANS Ensembl:ENSG00000095380 euGenes: HUgn54187
    ECgene: NANS Kegg: 54187 H-InvDB: NANS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NANS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NANS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NANS gene:
    Search GeneIP for patents involving NANS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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