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Aliases for NANS Gene

Aliases for NANS Gene

  • N-Acetylneuraminate Synthase 2 3 4 5
  • N-Acetylneuraminic Acid Synthase 2 3 4
  • N-Acetylneuraminic Acid Phosphate Synthase 3 4
  • N-Acetylneuraminate-9-Phosphate Synthase 3 4
  • SAS 3 4
  • Epididymis Secretory Protein Li 100 3
  • Sialic Acid Phosphate Synthase 3
  • Sialic Acid Synthase 2
  • EC 2.5.1.56 4
  • EC 2.5.1.57 4
  • HEL-S-100 3

External Ids for NANS Gene

Previous GeneCards Identifiers for NANS Gene

  • GC09P092562
  • GC09P094276
  • GC09P096198
  • GC09P097898
  • GC09P099858
  • GC09P100818
  • GC09P070419

Summaries for NANS Gene

Entrez Gene Summary for NANS Gene

  • This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]

GeneCards Summary for NANS Gene

NANS (N-Acetylneuraminate Synthase) is a Protein Coding gene. Diseases associated with NANS include fusariosis and hard palate cancer. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include N-acylneuraminate cytidylyltransferase activity and N-acetylneuraminate synthase activity.

UniProtKB/Swiss-Prot for NANS Gene

  • Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

Gene Wiki entry for NANS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANS Gene

Genomics for NANS Gene

Regulatory Elements for NANS Gene

Promoters for NANS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NANS on UCSC Golden Path with GeneCards custom track

Genomic Location for NANS Gene

Chromosome:
9
Start:
98,056,677 bp from pter
End:
98,083,083 bp from pter
Size:
26,407 bases
Orientation:
Plus strand

Genomic View for NANS Gene

Genes around NANS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANS Gene

Proteins for NANS Gene

  • Protein details for NANS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR45-SIAS_HUMAN
    Recommended name:
    Sialic acid synthase
    Protein Accession:
    Q9NR45
    Secondary Accessions:
    • B2RE98
    • Q8WUV9
    • Q9BWS6
    • Q9NVD4

    Protein attributes for NANS Gene

    Size:
    359 amino acids
    Molecular mass:
    40308 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NANS Gene

neXtProt entry for NANS Gene

Proteomics data for NANS Gene at MOPED

Post-translational modifications for NANS Gene

  • Ubiquitination at Lys 290
  • Modification sites at PhosphoSitePlus

Other Protein References for NANS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NANS Gene

Domains & Families for NANS Gene

Suggested Antigen Peptide Sequences for NANS Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR45

UniProtKB/Swiss-Prot:

SIAS_HUMAN :
  • Contains 1 AFP-like domain.
Domain:
  • Contains 1 AFP-like domain.
genes like me logo Genes that share domains with NANS: view

No data available for Gene Families for NANS Gene

Function for NANS Gene

Molecular function for NANS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

Enzyme Numbers (IUBMB) for NANS Gene

genes like me logo Genes that share phenotypes with NANS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NANS

miRNA for NANS Gene

miRTarBase miRNAs that target NANS

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NANS Gene

Localization for NANS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANS Gene COMPARTMENTS Subcellular localization image for NANS gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NANS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 10749855
genes like me logo Genes that share ontologies with NANS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NANS Gene

Pathways & Interactions for NANS Gene

genes like me logo Genes that share pathways with NANS: view

Interacting Proteins for NANS Gene

Gene Ontology (GO) - Biological Process for NANS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with NANS: view

No data available for SIGNOR curated interactions for NANS Gene

Drugs & Compounds for NANS Gene

(1) Drugs for NANS Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
phosphoenolpyruvate Experimental Pharma 0

(11) Additional Compounds for NANS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetyl-D-mannosamine 6-phosphate
  • ManNAc-6-P
  • N-Acetyl-D-mannosamine 6-phosphate
  • N-Acetyl-D-mannosamine-6-P
  • N-Acetyl-D-mannosamine-6-phosphate
  • N-Acetylmannosamine-6-P
873185-52-5
N-Acetylmannosamine
  • 2-Acetamido-2-deoxy-D-mannopyranose
  • 2-Acetamido-2-deoxy-D-mannose
  • ManNAc
  • N-Acetyl-D-mannosamine
  • N-Acetylmannosamine
3615-17-6
N-Acetylneuraminate 9-phosphate
N-Acetylneuraminic acid
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-b-D-galacto-2-Nonulopyranosonate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-b-D-galacto-2-Nonulopyranosonic acid
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonic acid
  • 5-(Acetylamino)-3,5-dideoxy-delta-glycero-beta-delta-galacto-2-Nonulopyranosonate
131-48-6
N-Acetylneuraminic acid 9-phosphate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonic acid 9-(dihydrogen phosphate)
  • N-Acetyl- 9-(dihydrogen phosphate)-Neuraminic acid
  • N-Acetyl-Neuraminic acid-9-phosphate
37992-17-9
genes like me logo Genes that share compounds with NANS: view

Transcripts for NANS Gene

Unigene Clusters for NANS Gene

N-acetylneuraminic acid synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NANS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7: - - - - - - - - - - -
SP8: -
SP9:

Relevant External Links for NANS Gene

GeneLoc Exon Structure for
NANS
ECgene alternative splicing isoforms for
NANS

Expression for NANS Gene

mRNA expression in normal human tissues for NANS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANS Gene

This gene is overexpressed in Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for NANS Gene

This gene is overexpressed in Salivary gland (9.7), Oral epithelium (7.4), and Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NANS Gene



SOURCE GeneReport for Unigene cluster for NANS Gene Hs.522310

mRNA Expression by UniProt/SwissProt for NANS Gene

Q9NR45-SIAS_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NANS: view

Protein tissue co-expression partners for NANS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NANS Gene

This gene was present in the common ancestor of animals.

Orthologs for NANS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANS 36
  • 100 (a)
OneToOne
NANS 35
  • 99.63 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NANS 35
  • 92.2 (n)
  • 96.66 (a)
NANS 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANS 36
  • 96 (a)
OneToOne
NANS 35
  • 92.48 (n)
  • 95.82 (a)
mouse
(Mus musculus)
Mammalia Nans 16
Nans 36
  • 95 (a)
OneToOne
Nans 35
  • 88.77 (n)
  • 94.71 (a)
oppossum
(Monodelphis domestica)
Mammalia NANS 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANS 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nans 35
  • 89.42 (n)
  • 94.99 (a)
chicken
(Gallus gallus)
Aves NANS 35
  • 80.63 (n)
  • 87.15 (a)
NANS 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NANS 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12473 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nans 35
  • 72.25 (n)
  • 75.98 (a)
Str.6775 35
zebrafish
(Danio rerio)
Actinopterygii nans 35
  • 73.72 (n)
  • 78.83 (a)
nans 36
  • 79 (a)
OneToMany
NANS (1 of 2) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004460 35
  • 52.69 (n)
  • 50.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sas 35
  • 54.45 (n)
  • 50.45 (a)
Sas 36
  • 46 (a)
OneToOne
Species with no ortholog for NANS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANS Gene

ENSEMBL:
Gene Tree for NANS (if available)
TreeFam:
Gene Tree for NANS (if available)

Paralogs for NANS Gene

No data available for Paralogs for NANS Gene

Variants for NANS Gene

Sequence variations from dbSNP and Humsavar for NANS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1058446 - 98,060,853(+) TTGGA(C/G/T)AGGCC upstream-variant-2KB, reference, missense
rs2181582 -- 98,070,718(+) cctgg(C/T)cacaa intron-variant
rs3832624 -- 98,056,627(-) GGGGC(-/G)GGGGG upstream-variant-2KB
rs2224773 -- 98,061,941(+) CAGGG(A/C)CTGGG intron-variant
rs7029176 -- 98,073,650(+) CTTTA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NANS Gene

Variant ID Type Subtype PubMed ID
nsv6628 CNV Insertion 18451855

Variation tolerance for NANS Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.64; 82.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANS Gene

HapMap Linkage Disequilibrium report
NANS
Human Gene Mutation Database (HGMD)
NANS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANS Gene

Disorders for NANS Gene

MalaCards: The human disease database

(3) MalaCards diseases for NANS Gene - From: DISEASES

Disorder Aliases PubMed IDs
fusariosis
  • fusarium infection
hard palate cancer
  • hard palate
leukemoid reaction
  • transient myeloproliferative disorder
- elite association - COSMIC cancer census association via MalaCards
Search NANS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NANS

Genetic Association Database (GAD)
NANS
Human Genome Epidemiology (HuGE) Navigator
NANS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANS
genes like me logo Genes that share disorders with NANS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANS Gene

Publications for NANS Gene

  1. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. (PMID: 10749855) Lawrence S.M. … Betenbaugh M.J. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Solution structure of the antifreeze-like domain of human sialic acid synthase. (PMID: 16597820) Hamada T. … Hirota H. (Protein Sci. 2006) 3 23
  3. Cloning, expression, and characterization of sialic acid synthases. (PMID: 16274664) Hao J. … Sundaramoorthy M. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NANS Gene

Sources for NANS Gene

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