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NANS Gene

protein-coding   GIFtS: 64
GCID: GC09P100818

N-Acetylneuraminic Acid Synthase

  See NANS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetylneuraminic Acid Synthase1 2 3     HEL-S-1002
SAS2 3 5     Epididymis Secretory Protein Li 1002
Sialic Acid Synthase1 2     Sialic Acid Phosphate Synthase2
N-Acetylneuraminate Synthase2 3     EC 2.5.1.563
N-Acetylneuraminate-9-Phosphate Synthase2 3     EC 2.5.1.573
N-Acetylneuraminic Acid Phosphate Synthase2 3     

External Ids:    HGNC: 192371   Entrez Gene: 541872   Ensembl: ENSG000000953807   OMIM: 6052025   UniProtKB: Q9NR453   

Export aliases for NANS gene to outside databases

Previous GC identifers: GC09P092562 GC09P094276 GC09P096198 GC09P097898 GC09P099858 GC09P070419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NANS Gene:
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded
protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated
forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN),
respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells,
expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid
synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative
mutant. (provided by RefSeq, Jul 2008)

GeneCards Summary for NANS Gene:
NANS (N-acetylneuraminic acid synthase) is a protein-coding gene. Diseases associated with NANS include hard palate cancer, and alexithymia. GO annotations related to this gene include N-acylneuraminate cytidylyltransferase activity and N-acetylneuraminate synthase activity.

UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can
also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms
of Neu5Ac and KDN, respectively

Gene Wiki entry for NANS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NANS gene promoter:
         Egr-3   STAT5B   Pax-5   Egr-1   STAT5A   CUTL1   LCR-F1   Egr-2   IRF-7A   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANS promoter sequence
   Search Chromatin IP Primers for NANS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1-p23   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9p24.1-p23

NANS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100818:  view genomic region     (about GC identifiers)

Start:
100,818,959 bp from pter      End:
100,845,365 bp from pter
Size:
26,407 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45 (See protein sequence)
Recommended Name: Sialic acid synthase  
Size: 359 amino acids; 40308 Da
1 PDB 3D structure from and Proteopedia for NANS:
1WVO (3D)    
Secondary accessions: B2RE98 Q8WUV9 Q9BWS6 Q9NVD4

Explore the universe of human proteins at neXtProt for NANS: NX_Q9NR45

Explore proteomics data for NANS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys290
  • Modification sites at PhosphoSitePlus

  • See NANS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061819.2  
    ENSEMBL proteins: 
     ENSP00000210444   ENSP00000404107   ENSP00000404642  
    Reactome Protein details: Q9NR45

    NANS Human Recombinant Protein Products:

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    OriGene Purified Protein for NANS
    OriGene Protein Over-expression Lysate for NANS
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    Novus Biologicals NANS Proteins
    Novus Biologicals NANS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NANS
    Cloud-Clone Corp. Proteins for NANS

     
    Search eBioscience for Proteins for NANS 

     
    antibodies-online proteins for NANS (17 products) 

     
    antibodies-online peptides for NANS

    NANS Antibody Products:

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    antibodies-online antibodies for NANS (28 products) 

    NANS Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NANS
    Cloud-Clone Corp. CLIAs for NANS
    Search eBioscience for ELISAs for NANS 
    antibodies-online kits for NANS (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR013974 SAF
     IPR006013 Antifreeze_III
     IPR013132 Neu5Ac_N
     IPR006190 AFP_Neu5c_C

    Graphical View of Domain Structure for InterPro Entry Q9NR45

    ProtoNet protein and cluster: Q9NR45

    2 Blocks protein domains:
    IPB006013 Type III antifreeze protein signature
    IPB013132 N-acetylneuraminic acid synthase


    UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
    Similarity: Contains 1 AFP-like domain


    Find genes that share domains with NANS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIAS_HUMAN, Q9NR45
    Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can
    also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms
    of Neu5Ac and KDN, respectively
    Catalytic activity: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate
    Catalytic activity: Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O = N-acylneuraminate 9-phosphate
    + phosphate

         Enzyme Numbers (IUBMB): EC 2.5.1.571 EC 2.5.1.561

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008781N-acylneuraminate cytidylyltransferase activity NAS10749855
    GO:0047444N-acylneuraminate-9-phosphate synthase activity IEA--
    GO:0050462N-acetylneuraminate synthase activity IEA--
         
    Find genes that share ontologies with NANS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NANS:
     Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NANS

    miRNA
    Products:
        
    miRTarBase miRNAs that target NANS:
    hsa-mir-324-5p (MIRT043076)

    Block miRNA regulation of human, mouse, rat NANS using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NANS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NANS

    Clone
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    OriGene ORF clones in mouse, rat for NANS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANS (NM_018946)
    Sino Biological Human cDNA Clone for NANS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANS

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS10749855
    GO:0005829cytosol IEA--

    Find genes that share ontologies with NANS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NANS About    
    See pathways by source

    SuperPathContained pathways About
    1Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism
    CMP-N-acetylneuraminate biosynthesis I (eukaryotes)0.00
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with NANS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NANS
        CMP-N-acetylneuraminate biosynthesis I (eukaryotes)


    1 Reactome Pathway for NANS
        Sialic acid metabolism


    2 Kegg Pathways  (Kegg details for NANS):
        Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NANS
    Interactions:

        Search GeneGlobe Interaction Network for NANS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NANS (Q9NR452, 3 ENSP000002104444) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3MINT-72658 I2D: score=2 
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    DDA1Q9BW613, ENSP000003529284I2D: score=3 STRING: ENSP00000352928
    ATG101Q9BSB43I2D: score=1 
    GOT1P171743I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009103lipopolysaccharide biosynthetic process NAS10749855
    GO:0016051carbohydrate biosynthetic process ----

    Find genes that share ontologies with NANS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NANS (SIAS)

    8 HMDB Compounds for NANS    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetyl-D-mannosamine 6-phosphateManNAc-6-P (see all 6)873185-52-5--
    N-Acetylmannosamine2-Acetamido-2-deoxy-D-mannose (see all 3)3615-17-6--
    N-Acetylneuraminate 9-phosphate ----
    N-Acetylneuraminic acidSialic acid (see all 55)131-48-6--
    N-Acetylneuraminic acid 9-phosphateN-acetyl- 9-(dihydrogen phosphate)-Neuraminic acid (see all 3)37992-17-9--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoenolpyruvic acid2-hydroxy-Acrylic acid dihydrogen phosphate (see all 6)138-08-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for NANS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-keto-3-deoxy-d-glycero-d-galacto-nononic acid 94.2 1 10749855 (1)
    sialic acid 81.7 29 16729195 (4), 16274664 (2), 16597820 (2), 14690432 (2) (see all 12)
    phosphoenolpyruvate 51.5 1 15888312 (1)
    n-acetylglucosamine 49 1 14690432 (1)



    Find genes that share compounds with NANS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NANS gene: 
    NM_018946.3  

    Unigene Cluster for NANS:

    N-acetylneuraminic acid synthase
    Hs.522310  [show with all ESTs]
    Unigene Representative Sequence: BQ706872
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000210444(uc004ayc.3) ENST00000495319 ENST00000480925 ENST00000461452
    ENST00000415280 ENST00000427646(uc004aye.1)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NANS
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    Primer
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    OriGene qPCR primer pairs and template standards for NANS
    OriGene qSTAR qPCR primer pairs in human, mouse for NANS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANS
      QuantiTect SYBR Green Assays in human, mouse, rat NANS
      QuantiFast Probe-based Assays in human, mouse, rat NANS

    Additional mRNA sequence: 

    AF257466.1 AK001659.1 AK316608.1 BC000008.2 BC019315.1 

    18 DOTS entries:

    DT.75138517  DT.100037659  DT.97860866  DT.99935837  DT.40129122  DT.40241205  DT.99986371  DT.100037657 
    DT.97860868  DT.100037658  DT.121164961  DT.121165009  DT.121165015  DT.92435154  DT.95258334  DT.97860871 
    DT.121164954  DT.95258404 

    Selected AceView cDNA sequences (see all 267):

    AA564277 BM069645 NM_018946 AW245927 BQ446501 BM772749 AA057865 AI032312 
    BE793764 AW249532 BP341076 BM563430 BF437450 CA417480 BU171085 AW004987 
    CR624153 BU727751 CR600247 BU195376 AA741294 BM982564 BU676733 BQ649507 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NANS (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                    -     -     -     -     -     -           -                                       
    SP2:                    -     -     -           -     -           -                                       
    SP3:                                            -     -                                                   
    SP4:                                                                                                      
    SP5:                                                                                      -               


    ECgene alternative splicing isoforms for NANS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NANS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAAAAAT
    NANS Expression
    About this image

    NANS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NANS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522310

    UniProtKB/Swiss-Prot: SIAS_HUMAN, Q9NR45
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for NANS
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    QuantiFast Probe-based Assays in human, mouse, rat NANS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NANS gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nans1 , 5 N-acetylneuraminic acid synthase (sialic acid synthase)1, 5 88.77(n)1
    94.71(a)1
      4 (24.83 cM)5
    941811  NM_053179.31  NP_444409.11 
     464892485 
    chicken
    (Gallus gallus)
    Aves NANS1 N-acetylneuraminic acid synthase 80.63(n)
    87.15(a)
      427283  NM_001007975.1  NP_001007976.1 
    lizard
    (Anolis carolinensis)
    Reptilia NANS6
    N-acetylneuraminic acid synthase
    85(a)
    1 ↔ 1
    GL343201.1(2372213-2387696)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124732 Xenopus laevis transcribed sequence with moderate similarity more 75.66(n)    CD301354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC050955.12   -- 77.69(n)    BC050955.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sas1 Sialic acid phosphate synthase 54.45(n)
    50.45(a)
      41528  NM_141938.1  NP_650195.1 


    ENSEMBL Gene Tree for NANS (if available)
    TreeFam Gene Tree for NANS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NANS (see all 271)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860233381,2
    --100817108(+) GCAATC/GCCGAA 1 -- us2k10--------
    rs126827851,2
    H--100817148(+) ggttcA/Cccatg 1 -- us2k10--------
    rs1897876291,2
    C--100817152(+) CACCAG/TGCCCA 1 -- us2k10--------
    rs1813886181,2
    --100817289(+) TCAGAA/GGTTTT 1 -- us2k10--------
    rs1115541111,2
    F--100817331(+) AGTTTC/TGCTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1404883301,2
    --100817595(+) TATGCC/TCCACC 1 -- us2k10--------
    rs1906591111,2
    --100817665(+) GTGCTA/GATTGG 1 -- us2k10--------
    rs1448991831,2
    --100817743(+) GGACAC/GAAGAT 1 -- us2k10--------
    rs1829135161,2
    --100817776(+) TGGTGC/GTGCCA 1 -- us2k10--------
    rs1860689401,2
    --100817790(+) GATCCA/GTCAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NANS (100818959 - 100845365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NANS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6628CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NANS
    DNA2.0 Custom Variant and Variant Library Synthesis for NANS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605202    OMIM disorders: --

    2 diseases for NANS:    
    About MalaCards
    hard palate cancer    alexithymia

    3 diseases from the University of Copenhagen DISEASES database for NANS:
    Cleft lip     Cleft palate     Hard palate cancer

    Find genes that share disorders with NANS           About GenesLikeMe

    Genetic Association Database (GAD): NANS
    Human Genome Epidemiology (HuGE) Navigator: NANS (1 document)

    Export disorders for NANS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NANS gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NANS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. (PubMed id 10749855)1, 2, 3, 9 Lawrence S.M.... Betenbaugh M.J. (J. Biol. Chem. 2000)
    2. Solution structure of the antifreeze-like domain of human sialic acid synthase. (PubMed id 16597820)1, 2, 9 Hamada T.... Hirota H. (Protein Sci. 2006)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cloning, expression, and characterization of sialic acid synthases. (PubMed id 16274664)1, 9 Hao J....Sundaramoorthy M. (Biochem. Biophys. Res. Commun. 2005)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54187 HGNC: 19237 AceView: NANS Ensembl:ENSG00000095380 euGenes: HUgn54187
    ECgene: NANS Kegg: 54187 H-InvDB: NANS

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NANS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NANS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NANS gene:
    Search GeneIP for patents involving NANS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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