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Aliases for NANS Gene

Aliases for NANS Gene

  • N-Acetylneuraminic Acid Synthase 2 3 4
  • SAS 3 4 6
  • N-Acetylneuraminic Acid Phosphate Synthase 3 4
  • N-Acetylneuraminate-9-Phosphate Synthase 3 4
  • N-Acetylneuraminate Synthase 3 4
  • Sialic Acid Synthase 2 3
  • Epididymis Secretory Protein Li 100 3
  • Sialic Acid Phosphate Synthase 3
  • EC 2.5.1.56 4
  • EC 2.5.1.57 4
  • HEL-S-100 3

External Ids for NANS Gene

Previous GeneCards Identifiers for NANS Gene

  • GC09P092562
  • GC09P094276
  • GC09P096198
  • GC09P097898
  • GC09P099858
  • GC09P100818
  • GC09P070419

Summaries for NANS Gene

Entrez Gene Summary for NANS Gene

  • This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]

GeneCards Summary for NANS Gene

NANS (N-Acetylneuraminic Acid Synthase) is a Protein Coding gene. Diseases associated with NANS include hard palate cancer and alexithymia. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include N-acylneuraminate cytidylyltransferase activity and N-acetylneuraminate synthase activity.

UniProtKB/Swiss-Prot for NANS Gene

  • Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively

Gene Wiki entry for NANS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANS Gene

Genomics for NANS Gene

Regulatory Elements for NANS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NANS Gene

Start:
98,056,677 bp from pter
End:
98,083,083 bp from pter
Size:
26,407 bases
Orientation:
Plus strand

Genomic View for NANS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NANS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANS Gene

Proteins for NANS Gene

  • Protein details for NANS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR45-SIAS_HUMAN
    Recommended name:
    Sialic acid synthase
    Protein Accession:
    Q9NR45
    Secondary Accessions:
    • B2RE98
    • Q8WUV9
    • Q9BWS6
    • Q9NVD4

    Protein attributes for NANS Gene

    Size:
    359 amino acids
    Molecular mass:
    40308 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NANS Gene

neXtProt entry for NANS Gene

Proteomics data for NANS Gene at MOPED

Post-translational modifications for NANS Gene

  • Ubiquitination at Lys290
  • Modification sites at PhosphoSitePlus

Other Protein References for NANS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NANS Gene

Domains for NANS Gene

Suggested Antigen Peptide Sequences for NANS Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR45

UniProtKB/Swiss-Prot:

SIAS_HUMAN :
  • Q9NR45
Domain:
  • Contains 1 AFP-like domain.
genes like me logo Genes that share domains with NANS: view

No data available for Gene Families for NANS Gene

Function for NANS Gene

Molecular function for NANS Gene

UniProtKB/Swiss-Prot CatalyticActivity: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate
UniProtKB/Swiss-Prot CatalyticActivity: Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate
UniProtKB/Swiss-Prot Function: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively

Enzyme Numbers (IUBMB) for NANS Gene

Gene Ontology (GO) - Molecular Function for NANS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0008781 N-acylneuraminate cytidylyltransferase activity NAS 10749855
GO:0047444 N-acylneuraminate-9-phosphate synthase activity IEA --
GO:0050462 N-acetylneuraminate synthase activity IEA --
genes like me logo Genes that share ontologies with NANS: view

Phenotypes for NANS Gene

GenomeRNAi human phenotypes for NANS:
genes like me logo Genes that share phenotypes with NANS: view

Animal Model Products

CRISPR Products

miRNA for NANS Gene

miRTarBase miRNAs that target NANS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NANS Gene

Localization for NANS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANS Gene COMPARTMENTS Subcellular localization image for NANS gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NANS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 10749855
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NANS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NANS Gene

Pathways for NANS Gene

genes like me logo Genes that share pathways with NANS: view

Pathways by source for NANS Gene

Interacting Proteins for NANS Gene

Gene Ontology (GO) - Biological Process for NANS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0009103 lipopolysaccharide biosynthetic process NAS 10749855
GO:0016051 carbohydrate biosynthetic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with NANS: view

Compounds for NANS Gene

(8) HMDB Compounds for NANS Gene

Compound Synonyms Cas Number PubMed IDs
N-Acetyl-D-mannosamine 6-phosphate
  • ManNAc-6-P
873185-52-5
N-Acetylmannosamine
  • 2-Acetamido-2-deoxy-D-mannose
3615-17-6
N-Acetylneuraminate 9-phosphate
Not Available
N-Acetylneuraminic acid
  • Sialic acid
131-48-6
N-Acetylneuraminic acid 9-phosphate
  • N-acetyl- 9-(dihydrogen phosphate)-Neuraminic acid
37992-17-9

(4) Novoseek inferred chemical compound relationships for NANS Gene

Compound -log(P) Hits PubMed IDs
2-keto-3-deoxy-d-glycero-d-galacto-nononic acid 94.2 1
sialic acid 81.7 18
phosphoenolpyruvate 51.5 1
n-acetylglucosamine 49 1
genes like me logo Genes that share compounds with NANS: view

Transcripts for NANS Gene

Unigene Clusters for NANS Gene

N-acetylneuraminic acid synthase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7: - - - - - - - - - - -
SP8: -
SP9:

Relevant External Links for NANS Gene

GeneLoc Exon Structure for
NANS
ECgene alternative splicing isoforms for
NANS

Expression for NANS Gene

mRNA expression in normal human tissues for NANS Gene

mRNA differential expression in normal tissues according to GTEx for NANS Gene

This gene is overexpressed in Colon - Transverse (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NANS Gene

SOURCE GeneReport for Unigene cluster for NANS Gene Hs.522310

mRNA Expression by UniProt/SwissProt for NANS Gene

Q9NR45-SIAS_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NANS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NANS Gene

Orthologs for NANS Gene

This gene was present in the common ancestor of animals.

Orthologs for NANS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANS 35
  • 99.63 (n)
  • 100 (a)
NANS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NANS 35
  • 92.2 (n)
  • 96.66 (a)
NANS 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANS 35
  • 92.48 (n)
  • 95.82 (a)
NANS 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nans 35
  • 88.77 (n)
  • 94.71 (a)
Nans 16
Nans 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANS 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANS 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nans 35
  • 89.42 (n)
  • 94.99 (a)
chicken
(Gallus gallus)
Aves NANS 35
  • 80.63 (n)
  • 87.15 (a)
NANS 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NANS 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12473 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nans 35
  • 72.25 (n)
  • 75.98 (a)
Str.6775 35
zebrafish
(Danio rerio)
Actinopterygii nans 35
  • 73.72 (n)
  • 78.83 (a)
nans 36
  • 79 (a)
OneToMany
NANS (1 of 2) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004460 35
  • 52.69 (n)
  • 50.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sas 35
  • 54.45 (n)
  • 50.45 (a)
Sas 36
  • 46 (a)
OneToOne
Species with no ortholog for NANS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANS Gene

ENSEMBL:
Gene Tree for NANS (if available)
TreeFam:
Gene Tree for NANS (if available)

Paralogs for NANS Gene

No data available for Paralogs for NANS Gene

Variants for NANS Gene

Sequence variations from dbSNP and Humsavar for NANS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_013308 -

Structural Variations from Database of Genomic Variants (DGV) for NANS Gene

Variant ID Type Subtype PubMed ID
nsv6628 CNV Insertion 18451855

Relevant External Links for NANS Gene

HapMap Linkage Disequilibrium report
NANS
Human Gene Mutation Database (HGMD)
NANS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANS Gene

Disorders for NANS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NANS Gene including...

Search for NANS Gene in MalaCards »

(3) University of Copenhagen DISEASES for NANS Gene

Relevant External Links for NANS

Genetic Association Database (GAD)
NANS
Human Genome Epidemiology (HuGE) Navigator
NANS
genes like me logo Genes that share disorders with NANS: view

No data available for UniProtKB/Swiss-Prot for NANS Gene

Publications for NANS Gene

  1. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. (PMID: 10749855) Lawrence S.M. … Betenbaugh M.J. (J. Biol. Chem. 2000) 2 3 4 23
  2. Solution structure of the antifreeze-like domain of human sialic acid synthase. (PMID: 16597820) Hamada T. … Hirota H. (Protein Sci. 2006) 3 4 23
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for NANS Gene

Sources for NANS Gene

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