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Aliases for NANP Gene

Aliases for NANP Gene

  • N-Acetylneuraminic Acid Phosphatase 2 3
  • HDHD4 3 4 6
  • Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 4 3 4
  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 4 2 3
  • Neu5Ac-9-Pase 3 4
  • C20orf147 3 4
  • Chromosome 20 Open Reading Frame 147 2
  • N-Acylneuraminate-9-Phosphatase 3
  • EC 4
  • DJ694B14.3 3

External Ids for NANP Gene

Previous HGNC Symbols for NANP Gene

  • C20orf147
  • HDHD4

Previous GeneCards Identifiers for NANP Gene

  • GC20M025543

Summaries for NANP Gene

GeneCards Summary for NANP Gene

NANP (N-Acetylneuraminic Acid Phosphatase) is a Protein Coding gene. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include N-acylneuraminate-9-phosphatase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANP Gene

Genomics for NANP Gene

Regulatory Elements for NANP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NANP Gene

25,612,935 bp from pter
25,624,175 bp from pter
11,241 bases
Minus strand

Genomic View for NANP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANP Gene

Proteins for NANP Gene

  • Protein details for NANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KP12
    • Q5JYN8
    • Q8TE97
    • Q9Y3N0

    Protein attributes for NANP Gene

    248 amino acids
    Molecular mass:
    27813 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NANP Gene

neXtProt entry for NANP Gene

Proteomics data for NANP Gene at MOPED

Post-translational modifications for NANP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NANP Gene

Domains for NANP Gene

Gene Families for NANP Gene

Suggested Antigen Peptide Sequences for NANP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily. NANP family.
  • Belongs to the HAD-like hydrolase superfamily. NANP family.
genes like me logo Genes that share domains with NANP: view

Function for NANP Gene

Molecular function for NANP Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P {ECO:0000269 PubMed:16237198}; KM=19.2 mM for fructose 1,6-P2 {ECO:0000269 PubMed:16237198}; KM=2.7 mM for 6-P-gluconate {ECO:0000269 PubMed:16237198}; KM=5.9 mM for N-acetylglucosamine 6-P {ECO:0000269 PubMed:16237198}; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate {ECO:0000269 PubMed:16237198}; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate {ECO:0000269 PubMed:16237198}; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.001 umol/min/mg enzyme with ATP as substrate {ECO:0000269 PubMed:16237198};
UniProtKB/Swiss-Prot CatalyticActivity:
N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate and calcium.

Enzyme Numbers (IUBMB) for NANP Gene

Gene Ontology (GO) - Molecular Function for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0050124 N-acylneuraminate-9-phosphatase activity TAS --
genes like me logo Genes that share ontologies with NANP: view

Phenotypes for NANP Gene

GenomeRNAi human phenotypes for NANP:
genes like me logo Genes that share phenotypes with NANP: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NANP Gene

Localization for NANP Gene

Subcellular locations from

Jensen Localization Image for NANP Gene COMPARTMENTS Subcellular localization image for NANP gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NANP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NANP Gene

Pathways for NANP Gene

genes like me logo Genes that share pathways with NANP: view

Pathways by source for NANP Gene

UniProtKB/Swiss-Prot Q8TBE9-NANP_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate biosynthesis

Interacting Proteins for NANP Gene

Gene Ontology (GO) - Biological Process for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006045 N-acetylglucosamine biosynthetic process IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0016311 dephosphorylation TAS --
genes like me logo Genes that share ontologies with NANP: view

Drugs for NANP Gene

(8) HMDB Compounds for NANP Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Magnesium
N-Acetylneuraminate 9-phosphate
N-Acetylneuraminic acid
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-b-D-galacto-2-Nonulopyranosonate
N-Acetylneuraminic acid 9-phosphate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonic acid 9-(dihydrogen phosphate)
genes like me logo Genes that share compounds with NANP: view

Transcripts for NANP Gene

mRNA/cDNA for NANP Gene

(51) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANP Gene

N-acetylneuraminic acid phosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NANP Gene

No ASD Table

Relevant External Links for NANP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NANP Gene

mRNA expression in normal human tissues for NANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NANP Gene

This gene is overexpressed in Adrenal (47.2) and Heart (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NANP Gene

SOURCE GeneReport for Unigene cluster for NANP Gene Hs.143137

genes like me logo Genes that share expressions with NANP: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for NANP Gene

Orthologs for NANP Gene

This gene was present in the common ancestor of animals.

Orthologs for NANP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NANP 35
  • 88.71 (n)
  • 94.35 (a)
  • 94 (a)
(Canis familiaris)
Mammalia NANP 35
  • 88.84 (n)
  • 91.13 (a)
-- 36
  • 89 (a)
-- 36
  • 91 (a)
(Mus musculus)
Mammalia Nanp 35
  • 86.5 (n)
  • 94.33 (a)
Nanp 16
Gm6741 36
  • 94 (a)
Nanp 36
  • 94 (a)
(Pan troglodytes)
Mammalia NANP 35
  • 96.37 (n)
  • 95.93 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Nanp 35
  • 86.91 (n)
  • 94.74 (a)
(Monodelphis domestica)
Mammalia NANP 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia NANP 36
  • 71 (a)
(Gallus gallus)
Aves NANP 35
  • 65.17 (n)
  • 74.29 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia NANP 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nanp 35
  • 62.32 (n)
  • 61.34 (a)
Str.17170 35
(Danio rerio)
Actinopterygii nanp 35
  • 54.72 (n)
  • 49.58 (a)
nanp 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004391 35
  • 44.15 (n)
  • 36.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15771 35
  • 45.66 (n)
  • 36.07 (a)
CG15771 36
  • 22 (a)
Species with no ortholog for NANP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANP Gene

Gene Tree for NANP (if available)
Gene Tree for NANP (if available)

Paralogs for NANP Gene Pseudogenes for NANP Gene

genes like me logo Genes that share paralogs with NANP: view

No data available for Paralogs for NANP Gene

Variants for NANP Gene

Sequence variations from dbSNP and Humsavar for NANP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs242130 -- 25,613,384(-) GGGGA(G/T)GTTTG utr-variant-3-prime
rs242131 -- 25,613,235(+) TCTTA(A/C)TGAAG utr-variant-3-prime
rs958075 -- 25,614,487(-) GGAAC(C/T)GGAGA utr-variant-3-prime
rs1569617 -- 25,612,727(+) CTGGC(C/G)TTggc downstream-variant-500B
rs2387976 -- 25,618,924(+) GAGCA(C/T)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NANP Gene

Variant ID Type Subtype PubMed ID
nsv522873 CNV Gain 19592680
dgv4560n71 CNV Gain 21882294
dgv4561n71 CNV Gain 21882294
nsv3342 CNV Insertion 18451855

Relevant External Links for NANP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANP Gene

Disorders for NANP Gene

(1) University of Copenhagen DISEASES for NANP Gene

genes like me logo Genes that share disorders with NANP: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for NANP Gene

Publications for NANP Gene

  1. Identification of the sequence encoding N-acetylneuraminate-9- phosphate phosphatase. (PMID: 16237198) Maliekal P. … Van Schaftingen E. (Glycobiology 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NANP Gene

  • Addgene plasmids for NANP

Sources for NANP Gene

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