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NANP Gene

protein-coding   GIFtS: 54
GCID: GC20M025593

N-Acetylneuraminic Acid Phosphatase

(Previous names: chromosome 20 open reading frame 147, haloacid dehalogenase-like...)
(Previous symbols: C20orf147, HDHD4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetylneuraminic Acid Phosphatase1 2     Neu5Ac-9-Pase2 3
HDHD41 2 3 5     Chromosome 20 Open Reading Frame 1471
C20orf1471 2 3     N-acylneuraminate-9-phosphatase2
Haloacid Dehalogenase-Like Hydrolase Domain Containing 41 2     dJ694B14.32
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 42 3     EC 3.1.3.293

External Ids:    HGNC: 161401   Entrez Gene: 1408382   Ensembl: ENSG000001701917   OMIM: 6107635   UniProtKB: Q8TBE93   

Export aliases for NANP gene to outside databases

Previous GC identifer: GC20M025543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NANP Gene:
NANP (N-acetylneuraminic acid phosphatase) is a protein-coding gene. Diseases associated with NANP include tetanus, and pneumonia. GO annotations related to this gene include N-acylneuraminate-9-phosphatase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the NANP gene promoter:
         TBP   AML1a   ATF-2   GATA-1   E47   CRE-BP1   TFIID   COMP1   Hand1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANP promoter sequence
   Search Chromatin IP Primers for NANP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.1   Ensembl cytogenetic band:  20p11.1   HGNC cytogenetic band: 20p11.1

NANP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025593:  view genomic region     (about GC identifiers)

Start:
25,593,571 bp from pter      End:
25,604,811 bp from pter
Size:
11,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9 (See protein sequence)
Recommended Name: N-acylneuraminate-9-phosphatase  
Size: 248 amino acids; 27813 Da
Cofactor: Magnesium
Sequence caution: Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic
DNA and not from cDNA;
3 PDB 3D structures from and Proteopedia for NANP:
2W4M (3D)        4KNV (3D)        4KNW (3D)    
Secondary accessions: B3KP12 Q5JYN8 Q8TE97 Q9Y3N0

Explore the universe of human proteins at neXtProt for NANP: NX_Q8TBE9

Explore proteomics data for NANP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NANP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689880.1  
    ENSEMBL proteins: 
     ENSP00000302441  
    Reactome Protein details: Q8TBE9

    NANP Human Recombinant Protein Products:

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    Novus Biologicals NANP Proteins
    Novus Biologicals NANP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NANP
    Cloud-Clone Corp. Proteins for NANP

    NANP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NANP
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    LSBio Antibodies in human, mouse, rat for NANP

    NANP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NANP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NANP
    Cloud-Clone Corp. CLIAs for NANP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011950 HAD-SF_hydro_IA_CTE7
     IPR023214 HAD-like_dom
     IPR006439 HAD-SF_hydro_IA

    Graphical View of Domain Structure for InterPro Entry Q8TBE9

    ProtoNet protein and cluster: Q8TBE9

    1 Blocks protein domain: IPB005833 Haloacid dehalogenase/epoxide hydrolase family signature

    UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9
    Similarity: Belongs to the HAD-like hydrolase superfamily. NANP family


    NANP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NANP_HUMAN, Q8TBE9
    Catalytic activity: N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphate
    Enzyme regulation: Inhibited by vanadate and calcium
    Biophysicochemical properties: Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P; KM=19.2 mM for fructose
    1,6-P2; KM=2.7 mM for 6-P-gluconate; KM=5.9 mM for N-acetylglucosamine 6-P; Vmax=112 umol/min/mg enzyme with
    N-acetylneuraminate 9-P as substrate; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate; Vmax=2.79
    umol/min/mg enzyme with 6-P-gluconate as substrate; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as
    substrate; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate; Vmax=0.140 umol/min/mg enzyme with 3-P
    glycerate as substrate; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate; Vmax=0.094 umol/min/mg enzyme
    with glycerol 3-P as substrate; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate; Vmax=0.072
    umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as
    substrate; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate; Vmax=0.023 umol/min/mg enzyme with
    glucosamine 6-P as substrate; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate; Vmax=0.019
    umol/min/mg enzyme with fructose 6-P as substrate; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate;
    Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as
    substrate; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate; Vmax=0.002 umol/min/mg enzyme with
    P-enolpyruvate as substrate; Vmax=0.001 umol/min/mg enzyme with ATP as substrate;

         Enzyme Number (IUBMB): EC 3.1.3.291

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
    GO:0050124N-acylneuraminate-9-phosphatase activity IDA16237198
         
    NANP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NANP:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Nanp (no phenotypes)

    NANP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NANP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NANP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NANP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NANP

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NANP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NANP (see all 19):
    hsa-miR-3673 hsa-miR-29c hsa-miR-29a hsa-miR-7-1* hsa-miR-3143 hsa-miR-3121-3p hsa-miR-613 hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidNANP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NANP
    Predesigned siRNA for gene silencing in human, mouse, rat NANP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NANP

    Clone
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    OriGene clones in human, mouse for NANP (see all 6)
    OriGene ORF clones in mouse, rat for NANP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANP (NM_152667)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NANP
    Browse ESI BIO Cell Lines and PureStem Progenitors for NANP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    NANP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NANP About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for NANP
        Sialic acid metabolism


    2 Kegg Pathways  (Kegg details for NANP):
        Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9
    Pathway: Amino-sugar metabolism; N-acetylneuraminate biosynthesis


    NANP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NANP
    Interactions:

        Search GeneGlobe Interaction Network for NANP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for NANP (Q8TBE93 ENSP000003024414) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTDNEP1O954763I2D: score=4 
    STXBP1P617643I2D: score=4 
    CMASENSP000002293294STRING: ENSP00000229329
    NANSENSP000002104444STRING: ENSP00000210444
    BICD1ENSP000002814744STRING: ENSP00000281474
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006045N-acetylglucosamine biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0016311dephosphorylation IDA16237198
    GO:0046380N-acetylneuraminate biosynthetic process IDA16237198

    NANP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NANP

    7 HMDB Compounds for NANP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    N-Acetylneuraminate 9-phosphate ----
    N-Acetylneuraminic acidSialic acid (see all 55)131-48-6--
    N-Acetylneuraminic acid 9-phosphateN-acetyl- 9-(dihydrogen phosphate)-Neuraminic acid (see all 3)37992-17-9--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NANP gene: 
    NM_152667.2  

    Unigene Cluster for NANP:

    N-acetylneuraminic acid phosphatase
    Hs.143137  [show with all ESTs]
    Unigene Representative Sequence: AL833116
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304788(uc002wuy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NANP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NANP (see all 19):
    hsa-miR-3673 hsa-miR-29c hsa-miR-29a hsa-miR-7-1* hsa-miR-3143 hsa-miR-3121-3p hsa-miR-613 hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidNANP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NANP
    Predesigned siRNA for gene silencing in human, mouse, rat NANP
    Clone
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    OriGene ORF clones in mouse, rat for NANP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANP (NM_152667)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANP
    Primer
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    OriGene qPCR primer pairs and template standards for NANP
    OriGene qSTAR qPCR primer pairs in human, mouse for NANP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANP
      QuantiTect SYBR Green Assays in human, mouse, rat NANP
      QuantiFast Probe-based Assays in human, mouse, rat NANP

    Additional mRNA sequence: 

    AK055472.1 AL833116.1 BC003415.1 BC022552.1 

    2 DOTS entries:

    DT.40297535  DT.100776215 

    Selected AceView cDNA sequences (see all 51):

    AI280765 AI422507 AW452991 BE045534 BU153984 AI150963 AI348660 AI130756 
    BX109319 BQ937679 CF126993 BF475385 AI129166 BG705027 BE909079 AI038808 
    BF511870 AL705194 BQ224337 AI146450 BU521496 BE867910 BX404146 BM801309 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NANP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACCTCCA
    NANP Expression
    About this image


    NANP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Heart (Cardiovascular System)
    NANP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NANP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143137
        Custom PCR Arrays for NANP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NANP
    OriGene qSTAR qPCR primer pairs in human, mouse for NANP
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    QuantiTect SYBR Green Assays in human, mouse, rat NANP
    QuantiFast Probe-based Assays in human, mouse, rat NANP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NANP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nanp1 , 5 N-acetylneuraminic acid phosphatase1, 5 86.5(n)1
    94.33(a)1
      2 (74.83 cM)5
    673111  NM_026086.21  NP_080362.11 
     1510296855 
    chicken
    (Gallus gallus)
    Aves NANP1 N-acetylneuraminic acid phosphatase 65.17(n)
    74.29(a)
      421467  NM_001031059.1  NP_001026230.1 
    lizard
    (Anolis carolinensis)
    Reptilia NANP6
    N-acetylneuraminic acid phosphatase
    60(a)
    1 ↔ 1
    1(232451473-232457684)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171702 Transcribed sequence with weak similarity to protein more 76.7(n)    BX780499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nanp1 N-acetylneuraminic acid phosphatase 54.72(n)
    49.58(a)
      553795  NM_001020757.1  NP_001018593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG157711 CG15771 45.66(n)
    36.07(a)
      31500  NM_132029.3  NP_572257.2 


    ENSEMBL Gene Tree for NANP (if available)
    TreeFam Gene Tree for NANP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NANP gene

    NANP for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NANP
    PGOHUM00000242195 PGOHUM00000244136 PGOHUM00000235738


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NANP (see all 275)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141368711,2
    F--25593138(+) AAAGTC/TAATGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1447227591,2
    --25593163(+) CGCACA/GTGGCT 1 -- int10--------
    rs1881917411,2
    --25593258(+) TTTCCC/TAAACT 1 -- int10--------
    rs1929423991,2
    --25593349(+) AGCTGG/TTAACA 1 -- int10--------
    rs15696171,2
    C,F,A,H--25593363(+) CTGGCG/CTTggc 1 -- int115Minor allele frequency- C:0.20NS EA WA NA CSA 785
    rs1839163981,2
    --25593544(+) TGGGCC/TCCTAG 1 -- int10--------
    rs1867522421,2
    --25593640(+) AATATA/GTTCCC 1 -- ut310--------
    rs124810371,2
    C,F,H--25593688(+) CGTAAC/TAAGAA 1 -- ut3117Minor allele frequency- T:0.24NS EA NA CSA 2114
    rs1912660281,2
    --25593713(+) TAAACA/CTATAA 1 -- ut310--------
    rs1485694331,2
    --25593773(+) ATATTG/TATTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NANP (25593571 - 25604811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NANP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3342CNV Insertion18451855
    dgv4560n71CNV Gain21882294
    dgv4561n71CNV Gain21882294
    nsv522873CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610763    OMIM disorders: --

    3 diseases for NANP:    
    About MalaCards
    tetanus    pneumonia    malaria

    1 disease from the University of Copenhagen DISEASES database for NANP:
    Malaria

    NANP for disorders           About GeneDecksing


    Export disorders for NANP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NANP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NANP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the sequence encoding N-acetylneuraminate-9- phosphate phosphatase. (PubMed id 16237198)1, 2, 3 Maliekal P.... Van Schaftingen E. (Glycobiology 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140838 HGNC: 16140 AceView: HDHD4 Ensembl:ENSG00000170191 euGenes: HUgn140838
    ECgene: NANP Kegg: 140838 H-InvDB: NANP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NANP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NANP gene:
    Search GeneIP for patents involving NANP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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