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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NANP Gene

protein-coding   GIFtS: 52
GCID: GC20M025593

N-acetylneuraminic acid phosphatase

(Previous names: chromosome 20 open reading frame 147, haloacid dehalogenase-like...)
(Previous symbols: C20orf147, HDHD4)
 Explore 3 diseases affiliated with
NANP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NANP    

Aliases
for NANP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Acetylneuraminic Acid Phosphatase1 2     Neu5Ac-9-Pase2 3
HDHD41 2 3 5     MGC268331
C20orf1471 2 3     Chromosome 20 Open Reading Frame 1471
DJ694B14.31     N-Acylneuraminate-9-Phosphatase1
Haloacid Dehalogenase-Like Hydrolase Domain Containing 41 2     EC 3.1.3.293
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 42 3     

External Ids:    HGNC: 161401   Entrez Gene: 1408382   Ensembl: ENSG000001701917   OMIM: 6107635   UniProtKB: Q8TBE93   

Export aliases for NANP gene to outside databases

Previous GC identifer: GC20M025543


Summaries
for NANP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for NANP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NANP gene promoter:
         TBP   AML1a   ATF-2   GATA-1   E47   CRE-BP1   TFIID   COMP1   Hand1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NANP promoter sequence
   Search SABiosciences Chromatin IP Primers for NANP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.1   Ensembl cytogenetic band:  20p11.1   HGNC cytogenetic band: 20p11.1

NANP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025593:  view genomic region     (about GC identifiers)

Start:
 25,593,571 bp from pter      End:
 25,604,811 bp from pter
Size:
 11,241 bases      Orientation:
 minus strand

Proteins
for NANP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9 (See protein sequence)
Recommended Name: N-acylneuraminate-9-phosphatase  
Size: 248 amino acids; 27813 Da
Cofactor: Magnesium
Sequence caution: Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and
not from cDNA;
1 PDB 3D structure from and Proteopedia for NANP:
2W4M (3D)    
Secondary accessions: B3KP12 Q5JYN8 Q8TE97 Q9Y3N0

Explore the universe of human proteins at neXtProt for NANP: NX_Q8TBE9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TBE9

    • NANP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689880.1  
    ENSEMBL proteins: 
     ENSP00000302441  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: NANP
    OriGene Protein Over-expression Lysate: NANP
    OriGene Custom Protein Services for NANP 
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    Novus Biologicals NANP Proteins
    Novus Biologicals NANP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NANP
    Uscn Proteins for NANP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    NANP for ontologies           About GeneDecksing



    NANP Antibody Products: 
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    OriGene Antibodies (see all 9): NANP
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    Novus Biologicals NANP Antibodies
    Search for Antibodies for NANP at Abcam  
    Uscn Antibodies for NANP
    Search ThermoFisher Antibodies for NANP

    Assay Products for NANP: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for NANP

    Protein Domains /
    Families
    for NANP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NANP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR005833 Haloacid_DH/epoxide_hydro
     IPR011950 HAD-SF_hydro_IA_CTE7
     IPR006439 HAD-SF_hydro_IA_v1
     IPR023214 HAD-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TBE9

    ProtoNet protein and cluster: Q8TBE9

    1 Blocks protein family: IPB005833 Haloacid dehalogenase/epoxide hydrolase family signature

    UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9
    Similarity: Belongs to the HAD-like hydrolase superfamily. NANP family


    Function
    for NANP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9
    Catalytic activity: N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphate
    Enzyme regulation: Inhibited by vanadate and calcium
    Biophysicochemical properties: Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P; KM=19.2 mM for fructose
    1,6-P2; KM=2.7 mM for 6-P-gluconate; KM=5.9 mM for N-acetylglucosamine 6-P; Vmax=112 umol/min/mg enzyme with
    N-acetylneuraminate 9-P as substrate; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate; Vmax=2.79
    umol/min/mg enzyme with 6-P-gluconate as substrate; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as
    substrate; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate; Vmax=0.140 umol/min/mg enzyme with 3-P
    glycerate as substrate; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate; Vmax=0.094 umol/min/mg enzyme with
    glycerol 3-P as substrate; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate; Vmax=0.072 umol/min/mg enzyme
    with N-acetylmannosamine 6-P as substrate; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate; Vmax=0.042
    umol/min/mg enzyme with ribose 6-P as substrate; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate;
    Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as
    substrate; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate; Vmax=0.016 umol/min/mg enzyme with glucose
    6-P as substrate; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate; Vmax=0.004 umol/min/mg enzyme with
    glucose 1-P as substrate; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate; Vmax=0.001 umol/min/mg
    enzyme with ATP as substrate;

    Enzyme Number (IUBMB): EC 3.1.3.291

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANP
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate NANP (see all 19):
    hsa-miR-3673 hsa-miR-29c hsa-miR-29a hsa-miR-7-1* hsa-miR-3143 hsa-miR-3121-3p hsa-miR-613 hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmid: NANP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NANP (see all 7)
    OriGene shRNA RFP: NANP
    OriGene siRNA: NANP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NANP

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NANP (see all 3)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANP 

    Cell Line
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    Search LifeMap BioReagents cell lines for NANP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008967phosphoglycolate phosphatase activity IEA--
    GO:0050124N-acylneuraminate-9-phosphatase activity IDA16237198


    NANP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for NANP:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Nanp (no phenotypes)

    NANP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NANP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino sugar and nucleotide sugar metabolism
    		Amino sugar and nucleotide sugar metabolism1.00
    2Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for NANP):
        Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9
    Pathway: Amino-sugar metabolism; N-acetylneuraminate biosynthesis


    NANP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NANP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for NANP (Q8TBE93 ENSP000003024414) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTDNEP1O954763I2D: score=4 
    STXBP1P617643I2D: score=4 
    CMASENSP000002293294STRING: ENSP00000229329
    NANSENSP000002104444STRING: ENSP00000210444
    HSPD1ENSP000003400194STRING: ENSP00000340019
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006045N-acetylglucosamine biosynthetic process IEA--
    GO:0046380N-acetylneuraminate biosynthetic process IDA16237198


    NANP for ontologies           About GeneDecksing



    Drugs & Compounds
    for NANP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NANP

    7 HMDB Compounds for NANP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    N-Acetylneuraminate 9-phosphate ----
    N-Acetylneuraminic acidSialic acid (see all 55)131-48-6--
    N-Acetylneuraminic acid 9-phosphateN-acetyl- 9-(dihydrogen phosphate)-Neuraminic acid (see all 3)37992-17-9--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about NANP 

    Transcripts
    for NANP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NANP gene: 
    NM_152667.2  

    Unigene Cluster for NANP:

    N-acetylneuraminic acid phosphatase
    Hs.143137  [show with all ESTs]
    Unigene Representative Sequence: AL833116
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304788(uc002wuy.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NANP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANP
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate NANP (see all 19):
    hsa-miR-3673 hsa-miR-29c hsa-miR-29a hsa-miR-7-1* hsa-miR-3143 hsa-miR-3121-3p hsa-miR-613 hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmid: NANP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NANP (see all 7)
    OriGene shRNA RFP: NANP
    OriGene siRNA: NANP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANP
    Clone
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    GenScript: all cDNA clones in your preferred vector: NANP (NM_152667)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NANP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANP

    Additional cDNA sequence: 

    AK055472.1 AL833116.1 BC003415.1 BC022552.1 

    2 DOTS entries:

    DT.40297535  DT.100776215 

    24/51 AceView cDNA sequences (see all 51):

    AI422507 BF475385 AI280765 AW452991 BE045534 CF126993 AI348660 AI150963 
    AI130756 BQ937679 BX109319 BU153984 AI129166 BM801309 BE909079 BE379200 
    AL705194 AI038808 BQ021092 BQ224337 NM_152667 BI092505 BX404146 AK074335 

    GeneLoc Exon Structure


    Expression
    for NANP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NANP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCACCTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NANP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NANP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NANP

    SOURCE GeneReport for Unigene cluster: Hs.143137
        SABiosciences Custom PCR Arrays for NANP
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANP
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANP

    Orthologs
    for NANP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NANP gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nanp1 , 5 N-acetylneuraminic acid phosphatase1, 5 86.5(n)1
    94.33(a)1    		   2 (74.83 cM)5
    673111  NM_026086.21  NP_080362.11 
     1510296855 
    chicken
    (Gallus gallus)    		 Aves NANP1 N-acetylneuraminic acid phosphatase 65.17(n)
    74.29(a)    		   421467  NM_001031059.1  NP_001026230.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NANP6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 1(232454257-232457374)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.171702 Transcribed sequence with weak similarity to protein more 76.7(n)    BX780499.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nanp1 N-acetylneuraminic acid phosphatase 54.86(n)
    49.58(a)    		   553795  NM_001020757.1  NP_001018593.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG157711 CG15771 45.66(n)
    36.07(a)    		   31500  NM_132029.3  NP_572257.2 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yjjG6
    		 dUMP phosphatase
    		 25(a)
    		 1 ↔ 1
    		 Chromosome(4606669-4607346)


    ENSEMBL Gene Tree for NANP (if available)
    TreeFam Gene Tree for NANP (if available) 

    Paralogs
    for NANP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NANP gene

    NANP for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NANP
    PGOHUM00000242195 PGOHUM00000244136 PGOHUM00000235738


    Genomic Variants
    for NANP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/216 NCBI SNPs in NANP are shown (see all 216)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1141368711,2
    		--25593138(+) AAAGTC/TAATGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1447227591,2
    		--25593163(+) CGCACA/GTGGCT 1 -- int10--------
    rs1881917411,2
    		--25593258(+) TTTCCC/TAAACT 1 -- int10--------
    rs1929423991,2
    		--25593349(+) AGCTGG/TTAACA 1 -- int10--------
    rs15696171,2
    		C,F,A,H,--25593363(+) CTGGCG/CTTGGC 1 -- int115Minor allele frequency- C:0.20NS EA WA NA CSA 785
    rs1839163981,2
    		--25593544(+) TGGGCC/TCCTAG 1 -- int10--------
    rs1867522421,2
    		--25593640(+) AATATA/GTTCCC 1 -- ut310--------
    rs124810371,2
    		C,F,H,--25593688(+) CGTAAC/TAAGAA 1 -- ut3117Minor allele frequency- T:0.24NS EA NA CSA 2114
    rs1912660281,2
    		--25593713(+) TAAACA/CTATAA 1 -- ut310--------
    rs1485694331,2
    		--25593773(+) ATATTG/TATTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NANP (25593571 - 25604811 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NANP
         1 CNV: 35914

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    Disorders / Diseases
    for NANP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NANP for disorders           About GeneDecksing

    OMIM gene information: 610763    OMIM disorders: --

    3 diseases for NANP:    About MalaCards
    tetanus    pneumonia    malaria

    1 disease from the University of Copenhagen DISEASES database for NANP:
    Malaria

    Export disorders for NANP gene to outside databases

    Publications
    for NANP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NANP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NANP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the sequence encoding N-acetylneuraminate-9- phosphate phosphatase. (PubMed id 16237198)1, 2, 3 Maliekal P.... Van Schaftingen E. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for NANP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NANP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140838 HGNC: 16140 AceView: HDHD4 Ensembl:ENSG00000170191 euGenes: HUgn140838
    ECgene: NANP Kegg: 140838 H-InvDB: NANP

    Other Databases showing NANP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NANP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NANP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NANP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NANP gene:
    Search GeneIP for patents involving NANP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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