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Aliases for NANP Gene

Aliases for NANP Gene

  • N-Acetylneuraminic Acid Phosphatase 2 3 5
  • Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 4 3 4
  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 4 2 3
  • Neu5Ac-9-Pase 3 4
  • C20orf147 3 4
  • HDHD4 3 4
  • Chromosome 20 Open Reading Frame 147 2
  • N-Acylneuraminate-9-Phosphatase 3
  • EC 3.1.3.29 4
  • DJ694B14.3 3

External Ids for NANP Gene

Previous HGNC Symbols for NANP Gene

  • C20orf147
  • HDHD4

Previous GeneCards Identifiers for NANP Gene

  • GC20M025543

Summaries for NANP Gene

GeneCards Summary for NANP Gene

NANP (N-Acetylneuraminic Acid Phosphatase) is a Protein Coding gene. Diseases associated with NANP include Parasitic Protozoa Infectious Disease and Chronic Rhinitis. Among its related pathways are Transport to the Golgi and subsequent modification and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include hydrolase activity and N-acylneuraminate-9-phosphatase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANP Gene

Genomics for NANP Gene

Regulatory Elements for NANP Gene

Enhancers for NANP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F025622 0.6 ENCODE 14 +0.5 495 2.9 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF337 NANP ZNF337-AS1 FAM182B RNU6ATAC17P
GH20F025669 0.9 Ensembl ENCODE 11.3 -45.8 -45845 1.1 SCRT1 CTCF CEBPB CEBPG RAD21 SCRT2 CEBPA BCL6 MAFK ZBTB26 ZNF337 NANP ZNF337-AS1 RNU6ATAC17P FAM182B GC20M025672 RN7SL594P
GH20F025686 1 ENCODE 11.2 -62.0 -62005 0.2 CTCF PKNOX1 REST ZNF337 NANP ZNF337-AS1 RNU6ATAC17P ENSG00000278383
GH20F025531 0.6 Ensembl ENCODE 10.4 +90.7 90688 3.6 GATAD2A CTCF ZNF280D HLF RAD21 ZKSCAN1 SREBF1 JUND ZNF302 CBX5 ZNF337 ABHD12 ZNF337-AS1 PYGB NINL NANP GC20P025533 PIR48473
GH20F025548 0.8 Ensembl ENCODE 10.4 +73.8 73836 3.5 SOX13 CTCF KLF1 TFAP4 SAP130 KLF17 ARID4B ZNF48 ZNF644 DNMT3B ABHD12 ZNF337 RNU6ATAC17P ZNF337-AS1 NANP FAM182B PIR43236 PIR44041
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NANP on UCSC Golden Path with GeneCards custom track

Promoters for NANP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000399452 475 2601 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302

Genomic Location for NANP Gene

Chromosome:
20
Start:
25,612,935 bp from pter
End:
25,624,175 bp from pter
Size:
11,241 bases
Orientation:
Minus strand

Genomic View for NANP Gene

Genes around NANP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANP Gene

Proteins for NANP Gene

  • Protein details for NANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBE9-NANP_HUMAN
    Recommended name:
    N-acylneuraminate-9-phosphatase
    Protein Accession:
    Q8TBE9
    Secondary Accessions:
    • B3KP12
    • Q5JYN8
    • Q8TE97
    • Q9Y3N0

    Protein attributes for NANP Gene

    Size:
    248 amino acids
    Molecular mass:
    27813 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NANP Gene

neXtProt entry for NANP Gene

Post-translational modifications for NANP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANP Gene

Domains & Families for NANP Gene

Gene Families for NANP Gene

Suggested Antigen Peptide Sequences for NANP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBE9

UniProtKB/Swiss-Prot:

NANP_HUMAN :
  • Belongs to the HAD-like hydrolase superfamily. NANP family.
Family:
  • Belongs to the HAD-like hydrolase superfamily. NANP family.
genes like me logo Genes that share domains with NANP: view

Function for NANP Gene

Molecular function for NANP Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P {ECO:0000269 PubMed:16237198}; KM=19.2 mM for fructose 1,6-P2 {ECO:0000269 PubMed:16237198}; KM=2.7 mM for 6-P-gluconate {ECO:0000269 PubMed:16237198}; KM=5.9 mM for N-acetylglucosamine 6-P {ECO:0000269 PubMed:16237198}; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate {ECO:0000269 PubMed:16237198}; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate {ECO:0000269 PubMed:16237198}; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.001 umol/min/mg enzyme with ATP as substrate {ECO:0000269 PubMed:16237198};
UniProtKB/Swiss-Prot CatalyticActivity:
N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate and calcium.

Enzyme Numbers (IUBMB) for NANP Gene

Gene Ontology (GO) - Molecular Function for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0050124 N-acylneuraminate-9-phosphatase activity TAS --
genes like me logo Genes that share ontologies with NANP: view
genes like me logo Genes that share phenotypes with NANP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NANP

miRNA for NANP Gene

miRTarBase miRNAs that target NANP

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NANP

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NANP Gene

Localization for NANP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANP Gene COMPARTMENTS Subcellular localization image for NANP gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NANP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NANP Gene

Pathways & Interactions for NANP Gene

genes like me logo Genes that share pathways with NANP: view

UniProtKB/Swiss-Prot Q8TBE9-NANP_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate biosynthesis.

Interacting Proteins for NANP Gene

Gene Ontology (GO) - Biological Process for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006045 N-acetylglucosamine biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0016311 dephosphorylation IEA --
GO:0046380 N-acetylneuraminate biosynthetic process IDA 16237198
genes like me logo Genes that share ontologies with NANP: view

No data available for SIGNOR curated interactions for NANP Gene

Drugs & Compounds for NANP Gene

(4) Drugs for NANP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0
Magnesium Nutra 0

(4) Additional Compounds for NANP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylneuraminate 9-phosphate
N-Acetylneuraminic acid
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-b-D-galacto-2-Nonulopyranosonate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-b-D-galacto-2-Nonulopyranosonic acid
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonic acid
  • 5-(Acetylamino)-3,5-dideoxy-delta-glycero-beta-delta-galacto-2-Nonulopyranosonate
131-48-6
N-Acetylneuraminic acid 9-phosphate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonic acid 9-(dihydrogen phosphate)
  • N-Acetyl- 9-(dihydrogen phosphate)-Neuraminic acid
  • N-Acetyl-Neuraminic acid-9-phosphate
37992-17-9
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with NANP: view

Transcripts for NANP Gene

mRNA/cDNA for NANP Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANP Gene

N-acetylneuraminic acid phosphatase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NANP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANP Gene

No ASD Table

Relevant External Links for NANP Gene

GeneLoc Exon Structure for
NANP
ECgene alternative splicing isoforms for
NANP

Expression for NANP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NANP Gene

This gene is overexpressed in Adrenal (47.2) and Heart (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NANP Gene



NURSA nuclear receptor signaling pathways regulating expression of NANP Gene:

NANP

SOURCE GeneReport for Unigene cluster for NANP Gene:

Hs.143137
genes like me logo Genes that share expression patterns with NANP: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NANP Gene

Orthologs for NANP Gene

This gene was present in the common ancestor of animals.

Orthologs for NANP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANP 34 35
  • 96.37 (n)
mouse
(Mus musculus)
Mammalia Gm6741 35
  • 94 (a)
OneToMany
Nanp 34 16 35
  • 86.5 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
NANP 34
  • 88.84 (n)
cow
(Bos Taurus)
Mammalia NANP 34 35
  • 88.71 (n)
rat
(Rattus norvegicus)
Mammalia Nanp 34
  • 86.91 (n)
oppossum
(Monodelphis domestica)
Mammalia NANP 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANP 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NANP 34 35
  • 65.17 (n)
lizard
(Anolis carolinensis)
Reptilia NANP 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nanp 34
  • 62.32 (n)
Str.17170 34
zebrafish
(Danio rerio)
Actinopterygii nanp 34 35
  • 54.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15771 34 35
  • 45.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004391 34
  • 44.15 (n)
Species where no ortholog for NANP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANP Gene

ENSEMBL:
Gene Tree for NANP (if available)
TreeFam:
Gene Tree for NANP (if available)

Paralogs for NANP Gene

Pseudogenes.org Pseudogenes for NANP Gene

genes like me logo Genes that share paralogs with NANP: view

No data available for Paralogs for NANP Gene

Variants for NANP Gene

Sequence variations from dbSNP and Humsavar for NANP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111254165 -- 25,619,458(+) TAATC(A/G)GAAAA intron-variant
rs111359514 -- 25,624,392(+) CCTGA(C/T)GTCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111421730 -- 25,625,104(+) GATTA(C/G)AGGCG intron-variant, upstream-variant-2KB
rs111785786 -- 25,618,557(+) TCACT(C/T)GCCAG intron-variant
rs112215614 -- 25,620,094(+) GGAAA(A/G)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NANP Gene

Variant ID Type Subtype PubMed ID
esv2762069 CNV loss 21179565
esv3645589 CNV loss 21293372
esv3893324 CNV gain 25118596
nsv3342 CNV insertion 18451855
nsv522873 CNV gain 19592680
nsv964384 CNV duplication 23825009

Variation tolerance for NANP Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANP Gene

Human Gene Mutation Database (HGMD)
NANP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANP Gene

Disorders for NANP Gene

MalaCards: The human disease database

(2) MalaCards diseases for NANP Gene - From: DISEASES

Disorder Aliases PubMed IDs
parasitic protozoa infectious disease
  • mastigophora infectious disease
chronic rhinitis
  • rhinitis - chronic
- elite association - COSMIC cancer census association via MalaCards
Search NANP in MalaCards View complete list of genes associated with diseases

Relevant External Links for NANP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANP
genes like me logo Genes that share disorders with NANP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANP Gene

Publications for NANP Gene

  1. Identification of the sequence encoding N-acetylneuraminate-9- phosphate phosphatase. (PMID: 16237198) Maliekal P. … Van Schaftingen E. (Glycobiology 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for NANP Gene

Sources for NANP Gene

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