NANP Gene
protein-coding GIFtS: 49
GC20M025543
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N-acetylneuraminic acid phosphatase (Previous names: chromosome 20 open reading frame 147, haloacid dehalogenase-like hydrolase domain containing 4 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: C20orf147, HDHD4)
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Aliases & Descriptions for NANP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
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| C20orf147 2, 3 | | EC 3.1.3.29 3 | | HDHD4 2, 3, 5 | | MGC26833 1, 2 | | N-acylneuraminate-9-phosphatase 2 | | Neu5Ac-9-Pase 2, 3 | | OTTHUMP00000030503 2 | | dJ694B14.3 1, 2 |
| | | Descriptions |
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Haloacid dehalogenase-like hydrolase domain-containing protein 4 3 | | N-acetylneuraminic acid phosphatase 2 | | chromosome 20 open reading frame 147 1 | | haloacid dehalogenase-like hydrolase domain containing 4 1, 2 |
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| | Search outside databases for aliases for NANP gene |
Summaries for NANP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for NANP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NANP gene 
Entrez Gene cytogenetic band: 20p11.1 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.1NANP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M025543:
(about GC identifiers)
Start:
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25,541,575 bp from pter |
End:
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25,552,621 bp from pter |
Size:
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11,047 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011387.8
| Proteins for NANP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9 (See
protein sequence)Recommended Name: N-acylneuraminate-9-phosphatase Size: 248 amino acids; 27813 Da
Cofactor: Magnesium
Sequence caution: Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA;
PDB structures from and Proteopedia :2W4M (3D)
 
Secondary accessions: Q5JYN8 Q8TE97 Q9Y3N0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_689880.1
ENSEMBL proteins: ENSP00000302441
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NANP 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for NANP: Assays for NANP: | Protein
Domains/ Families for NANP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8TBE9
ProtoNet protein and cluster: Q8TBE9 1 Blocks protein family: IPB005833 Haloacid dehalogenase/epoxide hydrolase family signature
UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9Similarity: Belongs to the HAD-like hydrolase superfamily. NANP family | Gene Function for NANP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152667
Applied Biosystems Silencer® siRNAs for NANP
Sigma-Aldrich siRNA for NANP  Sigma-Aldrich shRNA for NANP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152667                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152667                                  untagged cDNA clone in CMV expression vector: NM_152667 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_152667
UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9Catalytic activity: N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphateEnzyme regulation: Inhibited by vanadate and calciumBiophysicochemical properties: Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P; KM=19.2 mM for fructose 1,6-P2; KM=2.7 mM for 6-P-gluconate; KM=5.9 mM for N-acetylglucosamine 6-P; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate; Vmax=0.001 umol/min/mg enzyme with ATP as substrate;Enzyme Number (IUBMB): EC 3.1.3.29 1 MGI phenotypic allele for Nanp (no phenotypes)
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for NANP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for NANP (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: NANP_HUMAN, Q8TBE9Pathway: Amino-sugar metabolism; N-acetylneuraminic acid biosynthesis3 Gene Ontology (GO) biological process terms (links to tree view): About this table
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Drugs & Compounds for NANP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for NANP
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Transcripts for NANP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152667
Sigma-Aldrich siRNA for NANP  Sigma-Aldrich shRNA for NANP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_152667 REFSEQ mRNAs for NANP gene: NM_152667.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_152667               OriGene GFP tagged cDNA clone in CMV expression vector: NM_152667                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152667                                  untagged cDNA clone in CMV expression vector: NM_152667  Additional cDNA sequence: AK055472.1 AL833116.1 BC003415.1 BC022552.1 2 DOTS entries: DT.40297535 DT.100776215 24/51 AceView cDNA sequences (see all 51
):AI150963 AI422507 AI129166 BQ937679 BX109319 CF126993 BF475385 AI130756 AW452991 AI348660 BE045534 AI280765 BU153984 BP351640 BQ224337 AK055472 BX404520 BM801309 AI693731 BI087780 BF511870 AL833116 AI146450 BG705027
highest scoring ESTs for NANP:AI146450 AK055472 AK074335 AL833116 BC022552 BG705027 BQ224337 BQ937679 BU153984 BX404146 Unigene Cluster for NANP: N-acetylneuraminic acid phosphatase Hs.143137 [show with all ESTs]Unigene Representative Sequence: AL833116
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000304788
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Expression for NANP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NANP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NANP
1 / 2 / 3 4 probe-sets matching NANP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.143137
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Orthologs for NANP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for NANP gene from 5/10 species (see all 10
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About this table Species with no ortholog for NANP
ENSEMBL Gene Tree for NANP | Paralogs for NANP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
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SNPs/Variants for NANP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for NANP (up to first 250kb)
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Disorders & Mutations for NANP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 610763
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Medical News for NANP(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for NANP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for NANP gene: |
Search for NANP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing NANP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
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| Other Databases showing NANP
(According to HUGE)
About This Section
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Specialized Databases showing NANP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Services for NANP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for NANP:

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| | Recombinant Proteins (NANP) | | Antibodies (NANP) |
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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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