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Aliases for NANOS3 Gene

Aliases for NANOS3 Gene

  • Nanos C2HC-Type Zinc Finger 3 2 3 5
  • NOS3 3 4
  • Nanos Homolog 3 (Drosophila) 2
  • Nanos Homolog 3 3
  • ZC2HC12C 3
  • NANOS1L 3
  • NOS-3 4

External Ids for NANOS3 Gene

Previous GeneCards Identifiers for NANOS3 Gene

  • GC19P013850
  • GC19P013851
  • GC19P013852
  • GC19P013854
  • GC19P013988
  • GC19P013559
  • GC19P013972

Summaries for NANOS3 Gene

GeneCards Summary for NANOS3 Gene

NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Spermatocytoma. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot for NANOS3 Gene

  • Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Additional gene information for NANOS3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS3 Gene

Genomics for NANOS3 Gene

Regulatory Elements for NANOS3 Gene

Enhancers for NANOS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H013011 2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -841.9 -841869 17.2 HDGF FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 FOS ZNF709 ZNF136 ZNF625 TRMT1 ZNF844 ZNF788 ZNF791 ZNF20 SYCE2 ZNF433
GH19H013115 1.8 FANTOM5 ENCODE dbSUPER 11.5 -743.1 -743128 7.7 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF791 ZNF136 ZNF442 MRI1 ZNF44 CCDC130 TRMT1 WDR83OS ZNF564 ZNF625
GH19H014471 1.3 Ensembl ENCODE 11.5 +613.2 613216 7.8 PKNOX1 ATF1 ZNF133 ZNF2 GLIS2 CBX5 ZNF143 ATF7 ZNF202 SP3 CCDC130 AKAP8 MRI1 ZNF333 BRD4 DCAF15 RFX1 DDX39A ADGRL1 NANOS3
GH19H013773 1.2 ENCODE 11.7 -87.4 -87391 2.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MRI1 C19orf53 MIR181C ENSG00000267735 CCDC130 ADGRL1 SYCE2 NANOS3 ZNF333 TRMT1
GH19H013747 1.1 ENCODE 11.6 -113.8 -113845 2.2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF302 TRMT1 CCDC130 DDX39A MRI1 DCAF15 SYCE2 RFX1 MIR181C ENSG00000267735 LOC284454
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NANOS3 on UCSC Golden Path with GeneCards custom track

Promoters for NANOS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107450 237 601 PKNOX1 ZFP64 ARID4B FEZF1 ZNF143 ZNF207 FOS SP3 JUNB REST

Genomic Locations for NANOS3 Gene

Genomic Locations for NANOS3 Gene
chr19:13,862,063-13,880,757
(GRCh38/hg38)
Size:
18,695 bases
Orientation:
Plus strand
chr19:13,972,877-13,991,571
(GRCh37/hg19)

Genomic View for NANOS3 Gene

Genes around NANOS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS3 Gene

Proteins for NANOS3 Gene

  • Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60323-NANO3_HUMAN
    Recommended name:
    Nanos homolog 3
    Protein Accession:
    P60323
    Secondary Accessions:
    • Q495E5

    Protein attributes for NANOS3 Gene

    Size:
    173 amino acids
    Molecular mass:
    18844 Da
    Quaternary structure:
    • Binds mRNA from germ cells. Interacts with PUM2 (By similarity).

    Alternative splice isoforms for NANOS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOS3 Gene

Post-translational modifications for NANOS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS3 Gene

Domains & Families for NANOS3 Gene

Gene Families for NANOS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NANOS3 Gene

Suggested Antigen Peptide Sequences for NANOS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60323

UniProtKB/Swiss-Prot:

NANO3_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
genes like me logo Genes that share domains with NANOS3: view

Function for NANOS3 Gene

Molecular function for NANOS3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Phenotypes From GWAS Catalog for NANOS3 Gene

Gene Ontology (GO) - Molecular Function for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS3: view
genes like me logo Genes that share phenotypes with NANOS3: view

Animal Models for NANOS3 Gene

MGI Knock Outs for NANOS3:

Animal Model Products

miRNA for NANOS3 Gene

miRTarBase miRNAs that target NANOS3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS3 Gene

Localization for NANOS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250 UniProtKB:P60324}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOS3 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IEA,IDA 21421998
GO:0005737 cytoplasm IDA,IEA 21421998
GO:0010494 cytoplasmic stress granule ISS --
GO:0048471 perinuclear region of cytoplasm IDA 22899867
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NANOS3 Gene

Pathways & Interactions for NANOS3 Gene

SuperPathways for NANOS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IMP 21421998
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS3 Gene

Drugs & Compounds for NANOS3 Gene

No Compound Related Data Available

Transcripts for NANOS3 Gene

mRNA/cDNA for NANOS3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS3 Gene

Nanos homolog 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS3 Gene

No ASD Table

Relevant External Links for NANOS3 Gene

GeneLoc Exon Structure for
NANOS3
ECgene alternative splicing isoforms for
NANOS3

Expression for NANOS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NANOS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene

This gene is overexpressed in Brain - Amygdala (x5.9), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Hippocampus (x5.0).

Protein differential expression in normal tissues from HIPED for NANOS3 Gene

This gene is overexpressed in Heart (58.4) and Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NANOS3 Gene



Protein tissue co-expression partners for NANOS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NANOS3 Gene:

NANOS3

SOURCE GeneReport for Unigene cluster for NANOS3 Gene:

Hs.127982

mRNA Expression by UniProt/SwissProt for NANOS3 Gene:

P60323-NANO3_HUMAN
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
genes like me logo Genes that share expression patterns with NANOS3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS3 Gene

Orthologs for NANOS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS3 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia NANOS3 33 34
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Nanos3 33
  • 79.2 (n)
mouse
(Mus musculus)
Mammalia Nanos3 33 16 34
  • 78.72 (n)
cow
(Bos Taurus)
Mammalia NANOS3 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANOS3 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANOS3 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NANOS3 34
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nanos3 33 34
  • 52.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta nos 34
  • 9 (a)
OneToMany
Species where no ortholog for NANOS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS3 Gene

ENSEMBL:
Gene Tree for NANOS3 (if available)
TreeFam:
Gene Tree for NANOS3 (if available)

Paralogs for NANOS3 Gene

Paralogs for NANOS3 Gene

(2) SIMAP similar genes for NANOS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS3: view

Variants for NANOS3 Gene

Sequence variations from dbSNP and Humsavar for NANOS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000108848 -- 13,877,147(+) GAGAG(A/G)GGAAG upstream-variant-2KB, utr-variant-5-prime
rs1000294725 -- 13,876,323(+) GTGTG(C/T)GTGTG upstream-variant-2KB
rs1001517292 -- 13,878,426(+) TAGAG(A/G)TGGGG intron-variant
rs1001818064 -- 13,876,244(+) AGCAA(C/T)TCTTC upstream-variant-2KB
rs1002045743 -- 13,881,158(+) GCCCC(A/G)GTGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NANOS3 Gene

Variant ID Type Subtype PubMed ID
nsv953979 CNV deletion 24416366
nsv833760 CNV loss 17160897
nsv833757 CNV loss 17160897

Variation tolerance for NANOS3 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOS3 Gene

Human Gene Mutation Database (HGMD)
NANOS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene

Disorders for NANOS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NANOS3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
spermatocytoma
  • spermatocytic seminoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NANOS3

Genetic Association Database (GAD)
NANOS3
Human Genome Epidemiology (HuGE) Navigator
NANOS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOS3
genes like me logo Genes that share disorders with NANOS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS3 Gene

Publications for NANOS3 Gene

  1. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton VT … Reijo Pera RA (Human molecular genetics 2011) 3 4 60
  2. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PMID: 17418157) Qin Y … Rajkovic A (Fertility and sterility 2007) 3 45 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 4 60
  5. Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. (PMID: 27768780) Panula S … Hovatta O (PloS one 2016) 3 60

Products for NANOS3 Gene

Sources for NANOS3 Gene

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