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Aliases for NANOS3 Gene

Aliases for NANOS3 Gene

  • Nanos C2HC-Type Zinc Finger 3 2 3 5
  • NOS3 3 4
  • Nanos Homolog 3 (Drosophila) 2
  • Nanos Homolog 3 3
  • ZC2HC12C 3
  • NANOS1L 3
  • NOS-3 4

External Ids for NANOS3 Gene

Previous GeneCards Identifiers for NANOS3 Gene

  • GC19P013850
  • GC19P013851
  • GC19P013852
  • GC19P013854
  • GC19P013988
  • GC19P013559
  • GC19P013972

Summaries for NANOS3 Gene

GeneCards Summary for NANOS3 Gene

NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Spermatocytoma. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot for NANOS3 Gene

  • Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS3 Gene

Genomics for NANOS3 Gene

Regulatory Elements for NANOS3 Gene

Enhancers for NANOS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F014078 1.4 FANTOM5 Ensembl 13.8 +216.5 216538 1.2 ZNF146 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 ADGRE5 RFX1
GH19F014076 0.7 Ensembl 12.5 +214.7 214738 0.4 SMARCE1 HDAC1 KLF1 ESRRA RFX1 PKNOX1 ZBTB7A KLF16 IKZF1 GLIS1 PRKACA MIR181C MIR181D NANOS3 C19orf57 CC2D1A GC19M014079 MISP3 MIR1199
GH19F013806 0.3 FANTOM5 11 -55.0 -54975 0.2 ZFHX2 ZNF157 ADNP HMBOX1 YY1 EGR2 NANOS3 ZSWIM4 RFX1 RN7SL619P ENSG00000267582
GH19F013773 0.5 ENCODE 10.9 -87.4 -87391 2.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 MRI1 ZNF333 C19orf53 ENSG00000267735 MIR181C CCDC130 SYCE2 ITGB1P1 NANOS3 TRMT1
GH19F013747 0.5 ENCODE 10.9 -113.8 -113845 2.2 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 CCDC130 MRI1 TRMT1 ENSG00000267735 MIR181C MIR24-2 ZNF333 SYCE2 RPS6P25 NANOS3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NANOS3 on UCSC Golden Path with GeneCards custom track

Promoters for NANOS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001816229 237 1001 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF143 ZNF207 FOS ZNF263 SP3

Genomic Location for NANOS3 Gene

Chromosome:
19
Start:
13,862,063 bp from pter
End:
13,880,757 bp from pter
Size:
18,695 bases
Orientation:
Plus strand

Genomic View for NANOS3 Gene

Genes around NANOS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS3 Gene

Proteins for NANOS3 Gene

  • Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60323-NANO3_HUMAN
    Recommended name:
    Nanos homolog 3
    Protein Accession:
    P60323
    Secondary Accessions:
    • Q495E5

    Protein attributes for NANOS3 Gene

    Size:
    173 amino acids
    Molecular mass:
    18844 Da
    Quaternary structure:
    • Binds mRNA from germ cells. Interacts with PUM2 (By similarity).

    Alternative splice isoforms for NANOS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOS3 Gene

Post-translational modifications for NANOS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS3 Gene

Domains & Families for NANOS3 Gene

Gene Families for NANOS3 Gene

Protein Domains for NANOS3 Gene

Suggested Antigen Peptide Sequences for NANOS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60323

UniProtKB/Swiss-Prot:

NANO3_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
  • Contains 1 nanos-type zinc finger.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
Similarity:
  • Contains 1 nanos-type zinc finger.
genes like me logo Genes that share domains with NANOS3: view

Function for NANOS3 Gene

Molecular function for NANOS3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Gene Ontology (GO) - Molecular Function for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS3: view
genes like me logo Genes that share phenotypes with NANOS3: view

Animal Models for NANOS3 Gene

MGI Knock Outs for NANOS3:

Animal Model Products

miRNA for NANOS3 Gene

miRTarBase miRNAs that target NANOS3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS3 Gene

Localization for NANOS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250 UniProtKB:P60324}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOS3 Gene COMPARTMENTS Subcellular localization image for NANOS3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IEA,IDA 21421998
GO:0005737 cytoplasm IEA,IDA 21421998
GO:0010494 cytoplasmic stress granule ISS --
GO:0048471 perinuclear region of cytoplasm IDA 22899867
genes like me logo Genes that share ontologies with NANOS3: view

Pathways & Interactions for NANOS3 Gene

SuperPathways for NANOS3 Gene

No Data Available

Interacting Proteins for NANOS3 Gene

Gene Ontology (GO) - Biological Process for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IMP 21421998
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS3 Gene

Transcripts for NANOS3 Gene

mRNA/cDNA for NANOS3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS3 Gene

Nanos homolog 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS3 Gene

No ASD Table

Relevant External Links for NANOS3 Gene

GeneLoc Exon Structure for
NANOS3
ECgene alternative splicing isoforms for
NANOS3

Expression for NANOS3 Gene

mRNA expression in normal human tissues for NANOS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene

This gene is overexpressed in Brain - Amygdala (x5.9), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Hippocampus (x5.0).

Protein differential expression in normal tissues from HIPED for NANOS3 Gene

This gene is overexpressed in Heart (58.4) and Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NANOS3 Gene



Protein tissue co-expression partners for NANOS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NANOS3 Gene:

NANOS3

SOURCE GeneReport for Unigene cluster for NANOS3 Gene:

Hs.127982

mRNA Expression by UniProt/SwissProt for NANOS3 Gene:

P60323-NANO3_HUMAN
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
genes like me logo Genes that share expression patterns with NANOS3: view

Primer Products

Orthologs for NANOS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS3 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia NANOS3 34 35
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Nanos3 34
  • 79.2 (n)
mouse
(Mus musculus)
Mammalia Nanos3 34 16 35
  • 78.72 (n)
cow
(Bos Taurus)
Mammalia NANOS3 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANOS3 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANOS3 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NANOS3 35
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nanos3 34 35
  • 52.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta nos 35
  • 9 (a)
OneToMany
Species where no ortholog for NANOS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS3 Gene

ENSEMBL:
Gene Tree for NANOS3 (if available)
TreeFam:
Gene Tree for NANOS3 (if available)

Paralogs for NANOS3 Gene

Paralogs for NANOS3 Gene

(2) SIMAP similar genes for NANOS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS3: view

Variants for NANOS3 Gene

Sequence variations from dbSNP and Humsavar for NANOS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403025 -- 13,875,741(+) aacag(A/G)gtctc upstream-variant-2KB
rs10406053 -- 13,876,372(+) CCAGG(C/G)TGGTC upstream-variant-2KB
rs10413657 -- 13,879,312(+) GAGGA(A/G)GGGCC intron-variant
rs10415565 -- 13,879,095(+) ccacc(A/G)cgcac intron-variant
rs111337223 -- 13,876,969(+) CACCC(C/T)GTGTC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NANOS3 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Variation tolerance for NANOS3 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOS3 Gene

Human Gene Mutation Database (HGMD)
NANOS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene

Disorders for NANOS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NANOS3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatocytoma
  • spermatocytic seminoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NANOS3

Genetic Association Database (GAD)
NANOS3
Human Genome Epidemiology (HuGE) Navigator
NANOS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOS3
genes like me logo Genes that share disorders with NANOS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS3 Gene

Publications for NANOS3 Gene

  1. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton V.T. … Reijo Pera R.A. (Hum. Mol. Genet. 2011) 3 4 64
  2. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PMID: 17418157) Qin Y. … Rajkovic A. (Fertil. Steril. 2007) 3 46 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 4 64
  5. The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition. (PMID: 25904364) Grelet S. … Nawrocki-Raby B. (J. Pathol. 2015) 3 64

Products for NANOS3 Gene

Sources for NANOS3 Gene

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