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NANOS3 Gene

protein-coding GIFtS: 47

GC19P013857

nanos homolog 3 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC120114 ^²
NANOS1L ^¹, ²
NOS3 ^¹, ², ³

Descriptions
nanos homolog 3 ^²
nanos homolog 3 (Drosophila) ^²

External Ids
HGNC: 22048¹
Entrez Gene: 342977²
UniProtKB: P60323³
Ensembl: ENSG00000187556⁷

Search outside databases for aliases for NANOS3 gene

Previous GC identifers: GC19P013850 GC19P013851 GC19P013852 GC19P013854

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323

Function: Involved in the maintenance of proximal germ cells by supporting their proliferation.

Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets

(By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NANOS3 gene

Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.13

NANOS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P013857: (about GC identifiers)

Start:	13,848,950 bp from pter
End:	13,852,571 bp from pter
Size:	3,622 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323 (See protein sequence)

Recommended Name: Nanos homolog 3

Size: 173 amino acids; 18844 Da

REFSEQ proteins: NP_001092092.1

ENSEMBL proteins:

ENSP00000341992 ENSP00000380687

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nanos3)
	Human Recombinant Proteins from Abnova (NANOS3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for NANOS3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NANOS3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Nanos3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for NANOS3

Assays for NANOS3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P60323

ProtoNet protein and cluster: P60323

1 Blocks protein family: IPB008705 Nanos RNA-binding

UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323

Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule

of zinc. It is essential for the translation repression activity of the protein (By similarity)

Similarity: Belongs to the nanos family

Similarity: Contains 1 nanos-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NANOS3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_292819

Applied Biosystems Silencer® siRNAs for NANOS3

Sigma-Aldrich siRNA for NANOS3

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098622
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098622
untagged cDNA clones in CMV expression vector (see all 2): NM_001098622

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001098622

UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323

Function: Involved in the maintenance of proximal germ cells by supporting their proliferation.

Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets

(By similarity)

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nanos3):

endocrine/exocrine gland

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Interacting proteins for NANOS3 (ENSP00000341992³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOS2	ENSP00000327251³	STRING (score=.795)
NOS3	ENSP00000297494³	STRING (score=.794)
HSP90AA2	ENSP00000335153³	STRING (score=.722)
IFNG	ENSP00000229135³	STRING (score=.715)
PTGS2	ENSP00000356438³	STRING (score=.715)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006417	regulation of translation	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007283	spermatogenesis	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0048477	oogenesis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NANOS3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NANOS3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_292819

Sigma-Aldrich siRNA for NANOS3

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001098622

REFSEQ mRNAs for NANOS3 gene:

NM_001098622.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001098622

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098622
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098622
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001098622

Additional cDNA sequence:

BC101209.2 BC101210.1

2 DOTS entries:

DT.95253997 DT.75126873

12 AceView cDNA sequences:

BM702754 BU729805 BI793167 AA970499 CK821052 BE043072 AW384535 AI801869

BE219497 BI792898 CK821051 BG203139

highest scoring ESTs for NANOS3:

BI792898 BI793167 BM702754 BU729805 AA970499 AW384535 BC101209 BE219497 BG203139 CK821051

Unigene Cluster for NANOS3:

Nanos homolog 3 (Drosophila)

Hs.127982 [show with all ESTs]

Unigene Representative Sequence: NM_001098622

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000339133 ENST00000397555

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NANOS3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NANOS3

¹ / ² / ³

3 probe-sets matching NANOS3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
66737_at²^{, 3}	U95-C	1	0.62	1.00	1.00	1.00	AI801869	0.80	0.83	0.82	1
240311_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AI801869	0.80	0.83	0.82	1
240311_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCACCTAGG

SOURCE GeneReport for Unigene cluster: Hs.127982

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NANOS3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NANOS3¹	--	nanos homolog 3 (Drosophila)	85.78(n) 84.67(a)	484912 XM_542028.2 XP_542028.2
chimpanzee (Pan troglodytes)	NANOS3¹	--	nanos homolog 3 (Drosophila)	99.31(n) 99.48(a)	747879 XM_001171060.1 XP_001171060.1
cow (Bos taurus)	NANOS3¹	--	nanos homolog 3 (Drosophila)	83.03(n) 82.63(a)	523375 XM_601672.3 XP_601672.2
rat (Rattus norvegicus)	Nanos3¹	--	nanos homolog 3 (Drosophila)	77.51(n) 77.51(a)	288909 XM_222459.3 XP_222459.2
mouse (Mus musculus)	Nanos3^{1, 5}	8⁵	nanos homolog 3 (Drosophila)^{1, 5}	77.12(n)¹ 77.51(a)¹	244551¹ NM_194059.2¹ NP_918948.1¹ AB095973⁵ BC119513⁵ (see all 6)

About this table Species with no ortholog for NANOS3

ENSEMBL Gene Tree for NANOS3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NANOS3 gene

NANOS2² NANOS1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/27 NCBI SNPs in NANOS3 are shown (see all 27 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs897790^1,2	A,C,F,H	13849040(-)	`CAGGCG/AGAAGG`	1	--	ut5¹		13		EU EA WA NA	1150
	rs2016163^1,2	A,C,F,H	13849416(-)	`TCACGT/CGTGGC`	1	T/T	syn¹ ese³		3		EU EA	298
	rs10413657^1,2	C,F,H	13851126(+)	`GAGGAG/AGGGCC`	1	--	int¹ trp³		4		EU EA WA	392
--	rs10415565^1,2	A,C	13850909(+)	`ccaccA/Gcgcac`	1	--	int¹		0	--	--	--	--
--	rs8102371^1,2	A,C	13850022(+)	`caggcA/Gtgagc`	1	--	int¹		0	--	--	--	--
--	rs7257073^1,2	F,H	13851473(+)	`ggggaC/Aagagg`	1	--	int¹		4		EU EA WA	414
--	rs7245892^1,2	A,C	13851771(+)	`ggaggC/Tggagg`	1	--	int¹		0	--	--	--	--
--	rs12982455^1,2	--	13848697(+)	`ACAAGA/GAGGGG`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs7251902^1,2	--	13848167(+)	`cagggA/Tttcac`	1	--	ng5¹		0	--	--	--	--
--	rs57138018^1,2	--	13848521(+)	`ACACA-/CAAAGAA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NANOS3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608229

Human Genome Epidemiology Navigator: NANOS3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for NANOS3 gene:

The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)^{3, 4} Bonaldo M.F....Soares M.B. (1996)
Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PubMed id 17418157)³ Qin Y....Rajkovic A. (2007)
Conserved role of nanos proteins in germ cell development. (PubMed id 12947200)³ Tsuda M....Saga Y. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 342977	HGNC: 22048	AceView: NANOS3	Ensembl:ENSG00000187556	euGenes: HUgn342977
ECgene: NANOS3	H-InvDB: NANOS3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NANOS3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NANOS3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NANOS3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NANOS3		Antibodies for NANOS3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NANOS3)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Nanos3)
	Antibodies (Nanos3)

Search OriGene for NANOS3

Search Tocris compounds for NANOS3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for NANOS3

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NANOS3 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for NANOS3

Summaries
for NANOS3

Genomic Location
for NANOS3

Proteins
for NANOS3

Protein Domains/
Families
for NANOS3

Gene Function
for NANOS3

Pathways & Interactions
for NANOS3

Drugs & Compounds
for NANOS3

Transcripts
for NANOS3

Expression
for NANOS3

Orthologs
for NANOS3

Paralogs
for NANOS3

SNPs/Variants
for NANOS3

Disorders & Mutations
for NANOS3

Medical News
for NANOS3

Publications
for NANOS3

Search for NANOS3

Genome Databases showing NANOS3

Other Databases showing NANOS3

Specialized Databases showing NANOS3

Licensable Technologies
for NANOS3

Services
for NANOS3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NANOS3 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor NANOS3

Summariesfor NANOS3

Genomic Locationfor NANOS3

Proteinsfor NANOS3

Protein Domains/Familiesfor NANOS3

Gene Functionfor NANOS3

Pathways & Interactionsfor NANOS3

Drugs & Compoundsfor NANOS3

Transcriptsfor NANOS3

Expression for NANOS3

Orthologsfor NANOS3

Paralogsfor NANOS3

SNPs/Variantsfor NANOS3

Disorders & Mutationsfor NANOS3

Medical Newsfor NANOS3

Publicationsfor NANOS3

Search for NANOS3

Genome Databases showing NANOS3

Other Databases showing NANOS3

Specialized Databases showing NANOS3

Licensable Technologiesfor NANOS3

Servicesfor NANOS3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NANOS3

Summaries
for NANOS3

Genomic Location
for NANOS3

Proteins
for NANOS3

Protein Domains/
Families
for NANOS3

Gene Function
for NANOS3

Pathways & Interactions
for NANOS3

Drugs & Compounds
for NANOS3

Transcripts
for NANOS3

Expression
for NANOS3

Orthologs
for NANOS3

Paralogs
for NANOS3

SNPs/Variants
for NANOS3

Disorders & Mutations
for NANOS3

Medical News
for NANOS3

Publications
for NANOS3

Licensable Technologies
for NANOS3

Services
for NANOS3