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Aliases for NANOS3 Gene

Aliases for NANOS3 Gene

  • Nanos Homolog 3 (Drosophila) 2 3 5
  • NOS3 3 4
  • NANOS1L 3
  • NOS-3 4

External Ids for NANOS3 Gene

Previous GeneCards Identifiers for NANOS3 Gene

  • GC19P013850
  • GC19P013851
  • GC19P013852
  • GC19P013854
  • GC19P013988
  • GC19P013559
  • GC19P013972

Summaries for NANOS3 Gene

GeneCards Summary for NANOS3 Gene

NANOS3 (Nanos Homolog 3 (Drosophila)) is a Protein Coding gene. Diseases associated with NANOS3 include spermatocytoma and premature ovarian failure. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot for NANOS3 Gene

  • Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS3 Gene

Genomics for NANOS3 Gene

Regulatory Elements for NANOS3 Gene

Promoters for NANOS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NANOS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NANOS3 Gene

Chromosome:
19
Start:
13,862,063 bp from pter
End:
13,880,757 bp from pter
Size:
18,695 bases
Orientation:
Plus strand

Genomic View for NANOS3 Gene

Genes around NANOS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS3 Gene

Proteins for NANOS3 Gene

  • Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60323-NANO3_HUMAN
    Recommended name:
    Nanos homolog 3
    Protein Accession:
    P60323
    Secondary Accessions:
    • Q495E5

    Protein attributes for NANOS3 Gene

    Size:
    173 amino acids
    Molecular mass:
    18844 Da
    Quaternary structure:
    • Binds mRNA from germ cells. Interacts with PUM2 (By similarity).

    Alternative splice isoforms for NANOS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOS3 Gene

Proteomics data for NANOS3 Gene at MOPED

Post-translational modifications for NANOS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NANOS3

No data available for DME Specific Peptides for NANOS3 Gene

Domains & Families for NANOS3 Gene

Protein Domains for NANOS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60323

UniProtKB/Swiss-Prot:

NANO3_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
  • Contains 1 nanos-type zinc finger.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
Similarity:
  • Contains 1 nanos-type zinc finger.
genes like me logo Genes that share domains with NANOS3: view

No data available for Gene Families for NANOS3 Gene

Function for NANOS3 Gene

Molecular function for NANOS3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
genes like me logo Genes that share phenotypes with NANOS3: view

Animal Models for NANOS3 Gene

MGI Knock Outs for NANOS3:

Animal Model Products

miRNA for NANOS3 Gene

miRTarBase miRNAs that target NANOS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS3 Gene

Localization for NANOS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250 UniProtKB:P60324}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOS3 Gene COMPARTMENTS Subcellular localization image for NANOS3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NANOS3 Gene

Pathways & Interactions for NANOS3 Gene

genes like me logo Genes that share pathways with NANOS3: view

Pathways by source for NANOS3 Gene

Interacting Proteins for NANOS3 Gene

Gene Ontology (GO) - Biological Process for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis ISS --
GO:0051726 regulation of cell cycle ISS --
GO:2001234 negative regulation of apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with NANOS3: view

No data available for SIGNOR curated interactions for NANOS3 Gene

Drugs & Compounds for NANOS3 Gene

No Compound Related Data Available

Transcripts for NANOS3 Gene

mRNA/cDNA for NANOS3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS3 Gene

Nanos homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS3 Gene

No ASD Table

Relevant External Links for NANOS3 Gene

GeneLoc Exon Structure for
NANOS3
ECgene alternative splicing isoforms for
NANOS3

Expression for NANOS3 Gene

mRNA expression in normal human tissues for NANOS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene

This gene is overexpressed in Brain - Amygdala (x5.9), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Hippocampus (x5.0).

Protein differential expression in normal tissues from HIPED for NANOS3 Gene

This gene is overexpressed in Heart (58.4) and Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NANOS3 Gene



SOURCE GeneReport for Unigene cluster for NANOS3 Gene Hs.127982

mRNA Expression by UniProt/SwissProt for NANOS3 Gene

P60323-NANO3_HUMAN
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
genes like me logo Genes that share expression patterns with NANOS3: view

Protein tissue co-expression partners for NANOS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NANOS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS3 36
  • 99 (a)
OneToOne
NANOS3 35
  • 99.18 (n)
  • 99.38 (a)
cow
(Bos Taurus)
Mammalia NANOS3 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANOS3 36
  • 70 (a)
OneToOne
NANOS3 35
  • 83.56 (n)
  • 82.88 (a)
mouse
(Mus musculus)
Mammalia Nanos3 16
Nanos3 35
  • 78.72 (n)
  • 81.56 (a)
Nanos3 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANOS3 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANOS3 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nanos3 35
  • 79.2 (n)
  • 81.56 (a)
chicken
(Gallus gallus)
Aves NANOS3 36
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nanos3 35
  • 52.21 (n)
  • 44.12 (a)
nanos3 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nos 36
  • 9 (a)
OneToMany
Species with no ortholog for NANOS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS3 Gene

ENSEMBL:
Gene Tree for NANOS3 (if available)
TreeFam:
Gene Tree for NANOS3 (if available)

Paralogs for NANOS3 Gene

Paralogs for NANOS3 Gene

(2) SIMAP similar genes for NANOS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS3: view

Variants for NANOS3 Gene

Sequence variations from dbSNP and Humsavar for NANOS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs897790 -- 13,877,226(-) CAGGC(A/G)GAAGG upstream-variant-2KB, utr-variant-5-prime
rs2016163 -- 13,877,602(-) TCACG(C/T)GTGGC reference, synonymous-codon
rs8102371 -- 13,878,208(+) caggc(A/G)tgagc intron-variant
rs10403025 -- 13,875,741(+) aacag(A/G)gtctc upstream-variant-2KB
rs10406053 -- 13,876,372(+) CCAGG(C/G)TGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NANOS3 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897
nsv911098 CNV Loss 21882294
dgv3738n71 CNV Loss 21882294
nsv911102 CNV Loss 21882294
dgv3739n71 CNV Loss 21882294
nsv833760 CNV Loss 17160897

Variation tolerance for NANOS3 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOS3 Gene

HapMap Linkage Disequilibrium report
NANOS3
Human Gene Mutation Database (HGMD)
NANOS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene

Disorders for NANOS3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NANOS3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spermatocytoma
  • spermatocytic seminoma
premature ovarian failure
  • hypergonadotropic hypogonadism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NANOS3

Genetic Association Database (GAD)
NANOS3
Human Genome Epidemiology (HuGE) Navigator
NANOS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOS3
genes like me logo Genes that share disorders with NANOS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS3 Gene

Publications for NANOS3 Gene

  1. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton V.T. … Reijo Pera R.A. (Hum. Mol. Genet. 2011) 3 4 67
  2. Homozygous inactivating mutation in NANOS3 in two sisters with primary ovarian insufficiency. (PMID: 25054146) Santos M.G. … Mendonca B.B. (Biomed Res Int 2014) 3
  3. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. (PMID: 24736845) Bhandari D. … Izaurralde E. (Genes Dev. 2014) 3
  4. A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency. (PMID: 24091668) Wu X. … Xu Y. (Cell Death Dis 2013) 3
  5. NANOS3 gene mutations in men with isolated sterility phenotype. (PMID: 19565640) Kusz K. … Jaruzelska J. (Mol. Reprod. Dev. 2009) 3

Products for NANOS3 Gene

Sources for NANOS3 Gene

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