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NANOS3 Gene

protein-coding   GIFtS: 48
GCID: GC19P013972

Nanos Homolog 3 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nanos Homolog 3 (Drosophila)1 2
NOS32 3 5
NANOS1L2
Nanos Homolog 32
NOS-33

External Ids:    HGNC: 220481   Entrez Gene: 3429772   Ensembl: ENSG000001875567   OMIM: 6082295   UniProtKB: P603233   

Export aliases for NANOS3 gene to outside databases

Previous GC identifers: GC19P013850 GC19P013851 GC19P013852 GC19P013854 GC19P013857 GC19P013988 GC19P013559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NANOS3 Gene:
NANOS3 (nanos homolog 3 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323
Function: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia
cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing
translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent
apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs)
from apoptosis

summary for NANOS3 Gene:
Endothelial nitric oxide synthase (eNOS), along with inducible nitric oxide synthase (iNOS) and neuronal
nitric oxide synthase (nNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and
molecular oxygen. It is activated at concentrations of calcium greater than 100 nM and requires
tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity.
eNOS is tightly regulated by co- and post-translational lipid modifications, phosphorylation by Akt/PKB, PKA
and AMPK and protein-protein interactions. Negative protein-protein interactions are mediated by Hsp90 and
Cav-1 in the Golgi and by NOSIP and NOSTRIN at the plasma membrane, whilst dynamin, porin and soluble
guanylyl cyclase are positive regulators of eNOS activity. eNOS is a critical mediator of cardiovascular
homeostasis through regulation of the diameter of blood vessels and maintenance of an antiproliferative and
antiapoptotic environment in the vasculature. The human gene encoding eNOS is localized to chromosome 7q36.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the NANOS3 gene promoter:
         SRF   AhR   SRF (504 AA)   MyoD   Arnt   PPAR-alpha   CP2   Sox9   NF-kappaB1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): NANOS3 promoter sequence
   Search Chromatin IP Primers for NANOS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANOS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.13   Ensembl cytogenetic band:  19p13.13   HGNC cytogenetic band: 19p13.13

NANOS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOS3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013972:  view genomic region     (about GC identifiers)

Start:
13,972,877 bp from pter      End:
13,991,571 bp from pter
Size:
18,695 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323 (See protein sequence)
Recommended Name: Nanos homolog 3  
Size: 173 amino acids; 18844 Da
Subunit: Binds mRNA from germ cells. Interacts with PUM2 (By similarity)
Developmental stage: Fetal ovary and fetal testis (at protein level)
Secondary accessions: Q495E5
Alternative splicing: 2 isoforms:  P60323-1   P60323-2   

Explore the universe of human proteins at neXtProt for NANOS3: NX_P60323

Explore proteomics data for NANOS3 at MOPED


See NANOS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001092092.1  
ENSEMBL proteins: 
 ENSP00000341992   ENSP00000380687  

NANOS3 Human Recombinant Protein Products:

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Search eBioscience for ELISAs for NANOS3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR024161 Znf_nanos-typ
 IPR008705 Nanos/Xcar2

Graphical View of Domain Structure for InterPro Entry P60323

ProtoNet protein and cluster: P60323

1 Blocks protein domain: IPB008705 Nanos RNA-binding

UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323
Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is
essential for the translation repression activity of the protein (By similarity)
Similarity: Belongs to the nanos family
Similarity: Contains 1 nanos-type zinc finger


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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NANO3_HUMAN, P60323
Function: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia
cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing
translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent
apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs)
from apoptosis

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003723RNA binding ISS--
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
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Phenotypes:
     3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nanos3):
 endocrine/exocrine gland  no phenotypic analysis  reproductive system 

Find genes that share phenotypes with NANOS3           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NANOS3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NANOS3

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miRNA
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miRTarBase miRNAs that target NANOS3:
hsa-mir-155-5p (MIRT007181), hsa-mir-335-5p (MIRT017773)

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Search for qRT-PCR Assays for microRNAs that regulate NANOS3
SwitchGear 3'UTR luciferase reporter plasmidNANOS3 3' UTR sequence
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GenScript: all cDNA clones in your preferred vector: NANOS3 (NM_001098622)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS3

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NANO3_HUMAN, P60323: Nucleus. Cytoplasm. Cytoplasmic granule (By similarity). Cytoplasm, P-body (By similarity).
Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of
proteins and RNAs that appear when the cell is under stress. Colocalizes with PUM2, EIF2S1 and TIAL1 in the
stress granules. Colocalizes with DCP1A in the P-body (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
extracellular2
cytosol1
mitochondrion1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000932cytoplasmic mRNA processing body ISS--
GO:0005634nucleus IDA--
GO:0005737cytoplasm IDA--
GO:0010494cytoplasmic stress granule ISS--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Pathways by sourceSee SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NANOS3 (see all 18)
    PKA Signaling
Sertoli-Sertoli Cell Junction Dynamics
Endothelin-1 Signaling Pathway
Relaxin Pathway
Cellular Effects of Sildenafil

3 Tocris Bioscience Pathways for NANOS3
    Akt Pathway
Apoptosis Pathway
VEGF Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NANOS3
Interactions:

    Search GeneGlobe Interaction Network for NANOS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for NANOS3 (ENSP000003419924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
AASDHENSP000002052144STRING: ENSP00000205214
DDX3XENSP000003828404STRING: ENSP00000382840
DDX3YENSP000003367254STRING: ENSP00000336725
DDX4ENSP000003470874STRING: ENSP00000347087
STAU1ENSP000003609224STRING: ENSP00000360922
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006417regulation of translation ISS--
GO:0007275multicellular organismal development IEA--
GO:0007281germ cell development IMP--
GO:0007283spermatogenesis ISS--
GO:0043066negative regulation of apoptotic process ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for NANOS3 available from Tocris Bioscience    About this table
CompoundAction CAS #
L-NIO dihydrochloridePotent eNOS inhibitor[36889-13-1]



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NANOS3 gene: 
NM_001098622.2  

Unigene Cluster for NANOS3:

Nanos homolog 3 (Drosophila)
Hs.127982  [show with all ESTs]
Unigene Representative Sequence: NM_001098622
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000591727 ENST00000591161 ENST00000339133(uc002mxj.4) ENST00000397555

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidNANOS3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat NANOS3
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GenScript: all cDNA clones in your preferred vector: NANOS3 (NM_001098622)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS3
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for NANOS3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANOS3
  QuantiTect SYBR Green Assays in human, mouse, rat NANOS3
  QuantiFast Probe-based Assays in human, mouse, rat NANOS3

Additional mRNA sequence: 

BC101209.2 BC101210.1 

2 DOTS entries:

DT.95253997  DT.75126873 

12 AceView cDNA sequences:

AA970499 BM702754 BU729805 BE043072 BI793167 CK821052 BE219497 CK821051 
BI792898 AI801869 AW384535 BG203139 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NANOS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCACCTAGG
NANOS3 Expression
About this image


NANOS3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Gonad
         Primordial Germ Cells Allantois
         Primordial germ cell-like cells
 
 Germ Cells (Reproductive System)
         Primordial germ cell-like cells
 
 Placenta (Extraembryonic Tissues)
         Primordial Germ Cells Allantois
 
 Testis (Reproductive System)
         Spermatogonium Type A Seminiferous Tubules
NANOS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NANOS3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.127982

UniProtKB/Swiss-Prot: NANO3_HUMAN, P60323
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages
of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the
oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round
spermatids (S3) and elongated spermatids

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NANOS3 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nanos31 , 5 nanos homolog 3 (Drosophila)1, 5 78.72(n)1
81.56(a)1
  8 (40.45 cM)5
2445511  NM_194059.21  NP_918948.11 
 841737335 
chicken
(Gallus gallus)
Aves NANOS36
nanos homolog 3 (Drosophila)
15(a)
1 ↔ 1
JH375862.1(9830-10903)
zebrafish
(Danio rerio)
Actinopterygii nanos31 nanos homolog 3 52.21(n)
44.12(a)
  140631  NM_131878.1  NP_571953.1 
fruit fly
(Drosophila melanogaster)
Insecta nos6
nanos
9(a)
1 → many
3R(14982962-14985924)


ENSEMBL Gene Tree for NANOS3 (if available)
TreeFam Gene Tree for NANOS3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NANOS3 gene
NANOS22  NANOS12  
2 SIMAP similar genes for NANOS3 using alignment to 1 protein entry:     NANO3_HUMAN:
NANOS1    NANOS2

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NANOS3 (see all 160)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1449107651,2
--13986341(+) GCTCCA/GTGGAG 1 -- us2k10--------
rs1168381491,2
F--13986379(+) GAGACA/GGGATC 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs1914094971,2
--13986407(+) GCTGGA/TGTGCA 1 -- us2k10--------
rs1479380031,2
--13986422(+) TGTGAC/TCTTAG 1 -- us2k10--------
rs1417747651,2
--13986460(+) CAAGCC/GTTGAT 1 -- us2k10--------
rs1124955451,2
F--13986471(+) CCTCCC/TGCCTC 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
rs759036141,2
F--13986492(+) GTAGCC/TGGAAC 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs801065651,2
--13986493(+) TAGCCA/GGAACC 1 -- us2k10--------
rs104030251,2
C,F,H--13986555(+) aacagG/Agtctc 1 -- us2k19Minor allele frequency- A:0.09NS NA WA 1014
rs1455185821,2
--13986611(+) CTCCTC/TGGCCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for NANOS3 (13972877 - 13991571 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for NANOS3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv911102CNV Loss21882294
nsv833757CNV Loss17160897
nsv833760CNV Loss17160897
dgv3738n71CNV Loss21882294
nsv911098CNV Loss21882294
dgv3739n71CNV Loss21882294

Human Gene Mutation Database (HGMD): NANOS3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NANOS3
DNA2.0 Custom Variant and Variant Library Synthesis for NANOS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608229    OMIM disorders: --


Find genes that share disorders with NANOS3           About GenesLikeMe

Genetic Association Database (GAD): NANOS3
Human Genome Epidemiology (HuGE) Navigator: NANOS3 (1 document)

Export disorders for NANOS3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NANOS3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NANOS3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. NANOS3 function in human germ cell development. (PubMed id 21421998)1, 2 Julaton V.T. and Reijo Pera R.A. (Hum. Mol. Genet. 2011)
  2. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PubMed id 17418157)1, 4 Qin Y....Rajkovic A. (Fertil. Steril. 2007)
  3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 2 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
  5. A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency. (PubMed id 24091668)1 Wu X....Xu Y. (amp 2013)
  6. NANOS3 gene mutations in men with isolated sterility phenotype. (PubMed id 19565640)1 Kusz K....Jaruzelska J. (Mol. Reprod. Dev. 2009)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Conserved role of nanos proteins in germ cell development. (PubMed id 12947200)1 Tsuda M....Saga Y. (Science 2003)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 342977 HGNC: 22048 AceView: NANOS3 Ensembl:ENSG00000187556 euGenes: HUgn342977
ECgene: NANOS3 H-InvDB: NANOS3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NANOS3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NANOS3 gene:
Search GeneIP for patents involving NANOS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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