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Aliases for NANOS3 Gene

Aliases for NANOS3 Gene

  • Nanos Homolog 3 (Drosophila) 2 3
  • NOS3 3 4 6
  • Nanos Homolog 3 3
  • NANOS1L 3
  • NOS-3 4

External Ids for NANOS3 Gene

Previous GeneCards Identifiers for NANOS3 Gene

  • GC19P013850
  • GC19P013851
  • GC19P013852
  • GC19P013854
  • GC19P013988
  • GC19P013559
  • GC19P013972

Summaries for NANOS3 Gene

GeneCards Summary for NANOS3 Gene

NANOS3 (Nanos Homolog 3 (Drosophila)) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Disease. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot for NANOS3 Gene

  • Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS3 Gene

Genomics for NANOS3 Gene

Regulatory Elements for NANOS3 Gene

Genomic Location for NANOS3 Gene

Start:
13,862,063 bp from pter
End:
13,880,757 bp from pter
Size:
18,695 bases
Orientation:
Plus strand

Genomic View for NANOS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NANOS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS3 Gene

Proteins for NANOS3 Gene

  • Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60323-NANO3_HUMAN
    Recommended name:
    Nanos homolog 3
    Protein Accession:
    P60323
    Secondary Accessions:
    • Q495E5

    Protein attributes for NANOS3 Gene

    Size:
    173 amino acids
    Molecular mass:
    18844 Da
    Quaternary structure:
    • Binds mRNA from germ cells. Interacts with PUM2 (By similarity).

    Alternative splice isoforms for NANOS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOS3 Gene

Proteomics data for NANOS3 Gene at MOPED

Post-translational modifications for NANOS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS3 Gene

Domains for NANOS3 Gene

Protein Domains for NANOS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60323

UniProtKB/Swiss-Prot:

NANO3_HUMAN :
  • P60323
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
Similarity:
  • Contains 1 nanos-type zinc finger.
genes like me logo Genes that share domains with NANOS3: view

No data available for Gene Families for NANOS3 Gene

Function for NANOS3 Gene

Molecular function for NANOS3 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Gene Ontology (GO) - Molecular Function for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with NANOS3: view
genes like me logo Genes that share phenotypes with NANOS3: view

Animal Model Products

CRISPR Products

miRNA for NANOS3 Gene

miRTarBase miRNAs that target NANOS3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANOS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NANOS3 Gene

Localization for NANOS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Colocalizes with DCP1A in the P-body (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOS3 Gene COMPARTMENTS Subcellular localization image for NANOS3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 21421998
GO:0005737 cytoplasm IDA 21421998
GO:0010494 cytoplasmic stress granule ISS --
GO:0048471 perinuclear region of cytoplasm IDA 22899867
genes like me logo Genes that share ontologies with NANOS3: view

Pathways for NANOS3 Gene

genes like me logo Genes that share pathways with NANOS3: view

Pathways by source for NANOS3 Gene

Interacting Proteins for NANOS3 Gene

Gene Ontology (GO) - Biological Process for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation ISS --
GO:0007275 multicellular organismal development IEA --
GO:0007281 germ cell development IMP 21421998
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS3: view

Transcripts for NANOS3 Gene

mRNA/cDNA for NANOS3 Gene

(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS3 Gene

Nanos homolog 3 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANOS3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NANOS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS3 Gene

No ASD Table

Relevant External Links for NANOS3 Gene

GeneLoc Exon Structure for
NANOS3
ECgene alternative splicing isoforms for
NANOS3

Expression for NANOS3 Gene

mRNA expression in normal human tissues for NANOS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene

This gene is overexpressed in Brain - Amygdala (5.9), Brain - Frontal Cortex (BA9) (5.9), Brain - Cortex (5.6), Brain - Anterior cingulate cortex (BA24) (5.5), and Brain - Hippocampus (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NANOS3 Gene

SOURCE GeneReport for Unigene cluster for NANOS3 Gene Hs.127982

mRNA Expression by UniProt/SwissProt for NANOS3 Gene

P60323-NANO3_HUMAN
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
genes like me logo Genes that share expressions with NANOS3: view

In Situ Assay Products

Orthologs for NANOS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS3 35
  • 99.18 (n)
  • 99.38 (a)
NANOS3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NANOS3 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANOS3 35
  • 83.56 (n)
  • 82.88 (a)
NANOS3 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nanos3 35
  • 78.72 (n)
  • 81.56 (a)
Nanos3 16
Nanos3 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANOS3 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANOS3 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nanos3 35
  • 79.2 (n)
  • 81.56 (a)
chicken
(Gallus gallus)
Aves NANOS3 36
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nanos3 35
  • 52.21 (n)
  • 44.12 (a)
nanos3 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nos 36
  • 9 (a)
OneToMany
Species with no ortholog for NANOS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS3 Gene

ENSEMBL:
Gene Tree for NANOS3 (if available)
TreeFam:
Gene Tree for NANOS3 (if available)

Paralogs for NANOS3 Gene

Paralogs for NANOS3 Gene

Selected SIMAP similar genes for NANOS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS3: view

Variants for NANOS3 Gene

Sequence variations from dbSNP and Humsavar for NANOS3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs897790 -- 13,877,226(-) CAGGC(A/G)GAAGG upstream-variant-2KB
rs2016163 -- 13,877,602(-) TCACG(C/T)GTGGC reference, synonymous-codon
rs7245892 -- 13,879,957(+) ggagg(C/T)ggagg intron-variant
rs7247395 -- 13,876,326(+) tgtgt(C/G/T)tgtgt upstream-variant-2KB
rs7251902 -- 13,876,353(+) caggg(A/T)ttcac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NANOS3 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897
nsv911098 CNV Loss 21882294
dgv3738n71 CNV Loss 21882294
nsv911102 CNV Loss 21882294
dgv3739n71 CNV Loss 21882294
nsv833760 CNV Loss 17160897

Relevant External Links for NANOS3 Gene

HapMap Linkage Disequilibrium report
NANOS3
Human Gene Mutation Database (HGMD)
NANOS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene

Disorders for NANOS3 Gene

Relevant External Links for NANOS3

Genetic Association Database (GAD)
NANOS3
Human Genome Epidemiology (HuGE) Navigator
NANOS3
genes like me logo Genes that share disorders with NANOS3: view

No data available for UniProtKB/Swiss-Prot for NANOS3 Gene

Publications for NANOS3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PMID: 17418157) Qin Y. … Rajkovic A. (Fertil. Steril. 2007) 3 48
  3. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton V.T. … Reijo Pera R.A. (Hum. Mol. Genet. 2011) 3 4
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NANOS3 Gene

Sources for NANOS3 Gene

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