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Aliases for NANOS2 Gene

Aliases for NANOS2 Gene

  • Nanos C2HC-Type Zinc Finger 2 2 3 5
  • NOS-2 3 4
  • NOS2 3 4
  • Nanos Homolog 2 (Drosophila) 2
  • Nanos Homolog 2 3
  • ZC2HC12B 3

External Ids for NANOS2 Gene

Previous GeneCards Identifiers for NANOS2 Gene

  • GC19U900395
  • GC19M051108
  • GC19M046416
  • GC19M042844

Summaries for NANOS2 Gene

GeneCards Summary for NANOS2 Gene

NANOS2 (Nanos C2HC-Type Zinc Finger 2) is a Protein Coding gene. GO annotations related to this gene include mRNA binding. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot for NANOS2 Gene

  • Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS2 Gene

Genomics for NANOS2 Gene

Regulatory Elements for NANOS2 Gene

Enhancers for NANOS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G045629 1.6 FANTOM5 Ensembl ENCODE 1.9 +283.4 283384 3.7 HDGF PKNOX1 ATF1 ZNF133 SIN3A FEZF1 BRCA1 YY1 ZNF302 FOS CCDC61 ENSG00000268810 IRF2BP1 PPP5D1 ENSG00000267114 EML2 IGFL4 NKPD1 NANOS2 EXOC3L2
GH19G045492 1.4 FANTOM5 ENCODE 2 +421.7 421679 2.1 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF766 ZNF143 FOS PPM1N ZNF180 CCDC61 RTN2 NKPD1 NANOS2 EXOC3L2
GH19G045927 1.3 Ensembl ENCODE 0.4 -13.0 -12991 1.1 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 PPP5D1 MYPOP IRF2BP1 SYMPK FOXA3 PNMA8B NOVA2 FKRP PNMA8A NANOS2
GH19G045952 1.2 Ensembl ENCODE 0.3 -39.8 -39819 4.7 ATF1 ZNF133 ARID4B SIN3A GLI4 ZNF2 ZNF766 GLIS2 CBX5 ZNF143 IGFL4 CCDC61 LOC105372421 PPP5D1 MYPOP MIR769 PGLYRP1 SYMPK FOXA3 HIF3A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NANOS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NANOS2 Gene

Chromosome:
19
Start:
45,913,214 bp from pter
End:
45,914,870 bp from pter
Size:
1,657 bases
Orientation:
Minus strand

Genomic View for NANOS2 Gene

Genes around NANOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS2 Gene

Proteins for NANOS2 Gene

  • Protein details for NANOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60321-NANO2_HUMAN
    Recommended name:
    Nanos homolog 2
    Protein Accession:
    P60321
    Secondary Accessions:
    • Q17R30
    • Q4G0P8

    Protein attributes for NANOS2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15132 Da
    Quaternary structure:
    • Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9.

neXtProt entry for NANOS2 Gene

Post-translational modifications for NANOS2 Gene

No Post-translational modifications

Other Protein References for NANOS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NANOS2

No data available for DME Specific Peptides for NANOS2 Gene

Domains & Families for NANOS2 Gene

Gene Families for NANOS2 Gene

Protein Domains for NANOS2 Gene

Suggested Antigen Peptide Sequences for NANOS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60321

UniProtKB/Swiss-Prot:

NANO2_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
genes like me logo Genes that share domains with NANOS2: view

Function for NANOS2 Gene

Molecular function for NANOS2 Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Gene Ontology (GO) - Molecular Function for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS2: view
genes like me logo Genes that share phenotypes with NANOS2: view

Animal Models for NANOS2 Gene

MGI Knock Outs for NANOS2:

Animal Model Products

CRISPR Products

miRNA for NANOS2 Gene

miRTarBase miRNAs that target NANOS2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS2 Gene

Localization for NANOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS2 Gene

Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOS2 gene
Compartment Confidence
nucleus 5
extracellular 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IDA 22899867
GO:0005737 cytoplasm IEA,IDA 19168545
GO:0048471 perinuclear region of cytoplasm IEA,IDA 19168545
genes like me logo Genes that share ontologies with NANOS2: view

Pathways & Interactions for NANOS2 Gene

SuperPathways for NANOS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process ISS,IEA --
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS2: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS2 Gene

Drugs & Compounds for NANOS2 Gene

No Compound Related Data Available

Transcripts for NANOS2 Gene

mRNA/cDNA for NANOS2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS2 Gene

Nanos homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS2 Gene

No ASD Table

Relevant External Links for NANOS2 Gene

GeneLoc Exon Structure for
NANOS2
ECgene alternative splicing isoforms for
NANOS2

Expression for NANOS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NANOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS2 Gene

This gene is overexpressed in Testis (x38.9).

Protein differential expression in normal tissues from HIPED for NANOS2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NANOS2 Gene



Protein tissue co-expression partners for NANOS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NANOS2 Gene:

NANOS2

SOURCE GeneReport for Unigene cluster for NANOS2 Gene:

Hs.434218

mRNA Expression by UniProt/SwissProt for NANOS2 Gene:

P60321-NANO2_HUMAN
Tissue specificity: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
genes like me logo Genes that share expression patterns with NANOS2: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS2 Gene

Orthologs for NANOS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS2 34 35
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia NANOS2 34 35
  • 85.99 (n)
dog
(Canis familiaris)
Mammalia NANOS2 34 35
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Nanos2 34 16 35
  • 75.49 (n)
rat
(Rattus norvegicus)
Mammalia Nanos2 34
  • 75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nos 35
  • 9 (a)
OneToMany
Species where no ortholog for NANOS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOS2 Gene

ENSEMBL:
Gene Tree for NANOS2 (if available)
TreeFam:
Gene Tree for NANOS2 (if available)

Paralogs for NANOS2 Gene

Paralogs for NANOS2 Gene

(2) SIMAP similar genes for NANOS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS2: view

Variants for NANOS2 Gene

Sequence variations from dbSNP and Humsavar for NANOS2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000051163 -- 45,914,120(+) GGCCT(A/G)GCTCC utr-variant-3-prime
rs1000550431 -- 45,916,193(+) CAGGT(A/G)CCCAC upstream-variant-2KB
rs1002045025 -- 45,916,134(+) TCTCC(A/G)CCTCC upstream-variant-2KB
rs1002811369 -- 45,916,378(+) AAAAA(A/T)AGCCC upstream-variant-2KB
rs1002863521 -- 45,913,057(+) CGTGG(G/T)GGGGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NANOS2 Gene

Variant ID Type Subtype PubMed ID
nsv2507 CNV insertion 18451855
nsv510770 CNV deletion 20534489

Variation tolerance for NANOS2 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS2 Gene

Disorders for NANOS2 Gene

Relevant External Links for NANOS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOS2

No disorders were found for NANOS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NANOS2 Gene

Publications for NANOS2 Gene

  1. The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. (PMID: 19168545) Kusz K.M. … Jaruzelska J. (Mol. Hum. Reprod. 2009) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J. … Reijo Pera R.A. (Dev. Genes Evol. 2003) 2 3 64
  4. Conserved role of nanos proteins in germ cell development. (PMID: 12947200) Tsuda M. … Saga Y. (Science 2003) 2 3 64
  5. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. (PMID: 24736845) Bhandari D. … Izaurralde E. (Genes Dev. 2014) 3 64

Products for NANOS2 Gene

Sources for NANOS2 Gene

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