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NANOS2 Gene

protein-coding   GIFtS: 50
GCID: GC19M046416

Nanos Homolog 2 (Drosophila)

  See NANOS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nanos Homolog 2 (Drosophila)1 2
NOS22 3 5
NOS-22 3
Nanos Homolog 22

External Ids:    HGNC: 232921   Entrez Gene: 3393452   Ensembl: ENSG000001884257   OMIM: 6082285   UniProtKB: P603213   

Export aliases for NANOS2 gene to outside databases

Previous GC identifers: GC19U900395 GC19M051108 GC19M042844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NANOS2 Gene:
NANOS2 (nanos homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with NANOS2 include spermatocytoma. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321
Function: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing
the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the
promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is
required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT
deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs
involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for
the assembly of P-bodies but is required for the maintenance of their normal state (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NANOS2 gene promoter:
         Tal-1   NRSF form 1   Lmo2   XBP-1   NRSF form 2   E47   Max   FOXO4   COMP1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NANOS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANOS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

NANOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOS2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046416:  view genomic region     (about GC identifiers)

Start:
46,416,472 bp from pter      End:
46,418,036 bp from pter
Size:
1,565 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321 (See protein sequence)
Recommended Name: Nanos homolog 2  
Size: 138 amino acids; 15132 Da
Subunit: Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 (By similarity)
Developmental stage: Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the
24-week fetus (at protein level)
Secondary accessions: Q17R30 Q4G0P8

Explore the universe of human proteins at neXtProt for NANOS2: NX_P60321

Explore proteomics data for NANOS2 at MOPED


See NANOS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001025032.1  
ENSEMBL proteins: 
 ENSP00000341021  

NANOS2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for NANOS2

 
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LSBio Antibodies in human, mouse, rat for NANOS2

NANOS2 Assay Products:

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Cloud-Clone Corp. ELISAs for NANOS2
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Search eBioscience for ELISAs for NANOS2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR024161 Znf_nanos-typ
 IPR008705 Nanos/Xcar2

Graphical View of Domain Structure for InterPro Entry P60321

ProtoNet protein and cluster: P60321

1 Blocks protein domain: IPB008705 Nanos RNA-binding

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321
Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is
essential for the translation repression activity of the protein (By similarity)
Similarity: Belongs to the nanos family
Similarity: Contains 1 nanos-type zinc finger


Find genes that share domains with NANOS2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NANO2_HUMAN, P60321
Function: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing
the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the
promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is
required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT
deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs
involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for
the assembly of P-bodies but is required for the maintenance of their normal state (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003723RNA binding IEA--
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with NANOS2           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nanos2):
 cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

Find genes that share phenotypes with NANOS2           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NANOS2
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NANOS2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NANOS2

miRNA
Products:
    
miRTarBase miRNAs that target NANOS2:
hsa-mir-26a-5p (MIRT007347)

Block miRNA regulation of human, mouse, rat NANOS2 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate NANOS2:
hsa-miR-1226
SwitchGear 3'UTR luciferase reporter plasmidNANOS2 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat NANOS2

Gene Editing
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GenScript: all cDNA clones in your preferred vector: NANOS2 (NM_001029861)
Sino Biological Human cDNA Clone for NANOS2
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS2

Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NANO2_HUMAN, P60321: Cytoplasm. Cytoplasm, P-body (By similarity). Cytoplasm, perinuclear region. Note=Localizes
at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of
the germ cells of the adult testis
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
nucleus3
cytosol1
mitochondrion1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000932cytoplasmic mRNA processing body ISS--
GO:0005737cytoplasm IDA19168545
GO:0048471perinuclear region of cytoplasm IDA19168545

Find genes that share ontologies with NANOS2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NANOS2
Interactions:

    Search GeneGlobe Interaction Network for NANOS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for NANOS2 (ENSP000003410214) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
CNOT1ENSP000003209494STRING: ENSP00000320949
CNOT3ENSP000002212324STRING: ENSP00000221232
RQCD1ENSP000002730644STRING: ENSP00000273064
CNOT6LENSP000002649034STRING: ENSP00000264903
CNOT7ENSP000003552794STRING: ENSP00000355279
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006402mRNA catabolic process ISS--
GO:0006417regulation of translation IEA--
GO:0007275multicellular organismal development IEA--
GO:0007283spermatogenesis ISS--
GO:0030718germ-line stem cell maintenance ISS--

Find genes that share ontologies with NANOS2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NANOS2 (NANO2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NANOS2 gene: 
NM_001029861.2  

Unigene Cluster for NANOS2:

Nanos homolog 2 (Drosophila)
Hs.434218  [show with all ESTs]
Unigene Representative Sequence: BC042883
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000341294(uc002pdu.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NANOS2 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate NANOS2:
hsa-miR-1226
SwitchGear 3'UTR luciferase reporter plasmidNANOS2 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat NANOS2
Clone
Products:
     
OriGene clones in human, mouse for NANOS2 (see all 5)
OriGene ORF clones in mouse, rat for NANOS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NANOS2 (NM_001029861)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS2
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for NANOS2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANOS2
  QuantiTect SYBR Green Assays in human, mouse, rat NANOS2
  QuantiFast Probe-based Assays in human, mouse, rat NANOS2

Additional mRNA sequence: 

BC042883.1 BC117484.1 BC117486.1 

1 DOTS entry:

DT.95361109 

3 AceView cDNA sequences:

BC042883 BI826677 BI463423 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NANOS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATCTTTTGT
NANOS2 Expression
About this image


NANOS2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         XY Germ Cells Testis Cord
 
 Gonad
         XY Germ Cells Testis Cord
NANOS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NANOS2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.434218

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321
Tissue specificity: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery
of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein
level)

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NANOS2 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nanos21 , 5 nanos homolog 2 (Drosophila)1, 5 75.49(n)1
76.47(a)1
  7 (9.45 cM)5
3784301  NM_194064.21  NP_918953.21 
 189875245 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 68)
Uncharacterized protein
(see all 68)
59(a)
55(a)
(see all 68)
many → 1
many → 1
(see all 68)
1(141249941-141252593)
GL343215.1(96034-96510)
fruit fly
(Drosophila melanogaster)
Insecta nos6
nanos
9(a)
1 → many
3R(14982962-14985924)


ENSEMBL Gene Tree for NANOS2 (if available)
TreeFam Gene Tree for NANOS2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NANOS2 gene
NANOS32  NANOS12  
2 SIMAP similar genes for NANOS2 using alignment to 1 protein entry:     NANO2_HUMAN:
NANOS1    NANOS3

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NANOS2 (see all 92)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1139384131,2
C,F--46416037(+) AAGAAA/GAAACA 1 -- int12Minor allele frequency- G:0.11CSA EA 122
rs1927071591,2
C--46416120(+) CTACTA/GAAAAT 1 -- int10--------
rs1431710481,2
C--46416152(+) GGTGCA/CTGTCT 1 -- int10--------
rs1178031891,2
C,F--46416176(+) CTCCGG/AAGGCT 1 -- int11Minor allele frequency- A:0.10EA 120
rs357560171,2
C--46416266(+) CGACA-/ACAGCAA 1 -- int10--------
rs105514211,2
C--46416267(+) GACAA-/CAGCAAA 1 -- int10--------
rs113845301,2
C--46416283(+) AAAAAA/-TTAGC 1 -- int11Minor allele frequency- -:0.00NA 2
rs1850634531,2
--46416321(+) GGGGCA/GCACCT 1 -- int10--------
rs1475083611,2
--46416454(+) AAAGAC/TGGAAA 1 -- int10--------
rs1895268281,2
--46416577(+) CTTCTA/TCTCTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for NANOS2 (46416472 - 46418036 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for NANOS2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv2507CNV Insertion18451855
nsv510770CNV Loss20534489

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NANOS2
DNA2.0 Custom Variant and Variant Library Synthesis for NANOS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608228    OMIM disorders: --

1 disease for NANOS2:    
About MalaCards
spermatocytoma

1 disease from the University of Copenhagen DISEASES database for NANOS2:
Spermatocytoma

Find genes that share disorders with NANOS2           About GenesLikeMe


Export disorders for NANOS2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NANOS2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NANOS2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. (PubMed id 19168545)1, 2 Kusz K.M.... Jaruzelska J. (Mol. Hum. Reprod. 2009)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Conserved role of nanos proteins in germ cell development. (PubMed id 12947200)1, 3 Tsuda M....Saga Y. (Science 2003)
  4. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PubMed id 12690449)1, 3 Jaruzelska J....Reijo Pera R.A. (Dev. Genes Evol. 2003)
  5. NANOS3 function in human germ cell development. (PubMed id 21421998)2 Julaton V.T. and Reijo Pera R.A. (Hum. Mol. Genet. 2011)
  6. Expression of nitric oxide synthases in keratinocytes after UVB irradiation. (PubMed id 14615895)1 Chang H.R....Yu H.S. (Arch. Dermatol. Res. 2003)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339345 HGNC: 23292 AceView: NANOS2 Ensembl:ENSG00000188425 euGenes: HUgn339345
ECgene: NANOS2 H-InvDB: NANOS2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NANOS2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NANOS2 gene:
Search GeneIP for patents involving NANOS2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse Kits and Assays available from EMD Millipore
 Browse Small Molecules at EMD Millipore
 Browse Purified and Recombinant Proteins at EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of NANOS2
 
 EMD Millipore genomic analysis products

  
 Antibodies for NANOS2 (Nanos2)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
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 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for NANOS2   OriGene RNAi products in human, mouse, rat for NANOS2  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene MassSpec something-or-other for NANOS2   OriGene clones in human, mouse for NANOS2  
 OriGene qSTAR qPCR primer pairs in human, mouse for NANOS2   OriGene Purified Protein for NANOS2  
 OriGene ORF clones in mouse, rat for NANOS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for NANOS2   OriGene Custom Protein Services for NANOS2  

 
 
 Block miRNA regulation of human, mouse, rat NANOS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NANOS2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANOS2 Predesigned siRNA for gene silencing in human, mouse, rat NANOS2
 QuantiFast Probe-based Assays in human, mouse, rat NANOS2 QuantiTect SYBR Green Assays in human, mouse, rat NANOS2
 Custom PCR Arrays for NANOS2 Search Chromatin IP Primers for NANOS2
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANOS2  Search GeneGlobe Interaction Network for NANOS2
 Regulatory tfbs in NANOS2 promoter
 GenScript Custom Purified and Recombinant Proteins Services for NANOS2 GenScript cDNA clones with any tag delivered in your preferred vector for NANOS2
 GenScript Custom Assay Services for NANOS2 GenScript Custom overexpressing Cell Line Services for NANOS2
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for NANOS2 (NANO2)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for NANOS2
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 NANOS2 antibodies
 NANOS2 proteins
 NANOS2 lysates
 Antibodies for NANOS2
 See all of Abcam's Antibodies, Kits and Proteins for NANOS2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for NANOS2
 Antibodies for NANOS2
 ELISAs for NANOS2
 CLIAs for NANOS2



 Browse ESI BIO Cell Lines and PureStem Progenitors for NANOS2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS2
 SwitchGear 3'UTR luciferase reporter plasmids for NANOS2
 Browse SwitchGear Promoter luciferase reporter plasmids for NANOS2
 ThermoFisher Antibodies for NANOS2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NANOS2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NANOS2
 LSBio Antibodies in human, mouse, rat for NANOS2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for NANOS2
  Search eBioscience for proteins for NANOS2
  Search eBioscience for elisas for NANOS2
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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