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Aliases for NANOS2 Gene

Aliases for NANOS2 Gene

  • Nanos Homolog 2 (Drosophila) 2 3
  • NOS2 3 4 6
  • NOS-2 3 4
  • Nanos Homolog 2 3

External Ids for NANOS2 Gene

Previous GeneCards Identifiers for NANOS2 Gene

  • GC19U900395
  • GC19M051108
  • GC19M046416
  • GC19M042844

Summaries for NANOS2 Gene

GeneCards Summary for NANOS2 Gene

NANOS2 (Nanos Homolog 2 (Drosophila)) is a Protein Coding gene. Diseases associated with NANOS2 include spermatocytoma. Among its related pathways are Disease and Pathways in cancer. GO annotations related to this gene include RNA binding. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot for NANOS2 Gene

  • Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS2 Gene

Genomics for NANOS2 Gene

Regulatory Elements for NANOS2 Gene

Genomic Location for NANOS2 Gene

Start:
45,913,214 bp from pter
End:
45,914,870 bp from pter
Size:
1,657 bases
Orientation:
Minus strand

Genomic View for NANOS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NANOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS2 Gene

Proteins for NANOS2 Gene

  • Protein details for NANOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60321-NANO2_HUMAN
    Recommended name:
    Nanos homolog 2
    Protein Accession:
    P60321
    Secondary Accessions:
    • Q17R30
    • Q4G0P8

    Protein attributes for NANOS2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15132 Da
    Quaternary structure:
    • Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9.

neXtProt entry for NANOS2 Gene

Proteomics data for NANOS2 Gene at MOPED

Post-translational modifications for NANOS2 Gene

No Post-translational modifications

Other Protein References for NANOS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NANOS2 Gene

Domains for NANOS2 Gene

Protein Domains for NANOS2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60321

UniProtKB/Swiss-Prot:

NANO2_HUMAN :
  • P60321
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
Similarity:
  • Contains 1 nanos-type zinc finger.
genes like me logo Genes that share domains with NANOS2: view

No data available for Gene Families for NANOS2 Gene

Function for NANOS2 Gene

Molecular function for NANOS2 Gene

UniProtKB/Swiss-Prot Function: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Gene Ontology (GO) - Molecular Function for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with NANOS2: view
genes like me logo Genes that share phenotypes with NANOS2: view

Animal Model Products

CRISPR Products

miRNA for NANOS2 Gene

miRTarBase miRNAs that target NANOS2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANOS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NANOS2 Gene

Localization for NANOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS2 Gene

Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOS2 Gene COMPARTMENTS Subcellular localization image for NANOS2 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 22899867
GO:0005737 cytoplasm IDA 19168545
GO:0048471 perinuclear region of cytoplasm IDA 19168545
genes like me logo Genes that share ontologies with NANOS2: view

Pathways for NANOS2 Gene

genes like me logo Genes that share pathways with NANOS2: view

Gene Ontology (GO) - Biological Process for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process ISS --
GO:0006417 regulation of translation --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS2: view

Transcripts for NANOS2 Gene

mRNA/cDNA for NANOS2 Gene

(3) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS2 Gene

Nanos homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANOS2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NANOS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS2 Gene

No ASD Table

Relevant External Links for NANOS2 Gene

GeneLoc Exon Structure for
NANOS2
ECgene alternative splicing isoforms for
NANOS2

Expression for NANOS2 Gene

mRNA expression in normal human tissues for NANOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS2 Gene

This gene is overexpressed in Testis (38.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NANOS2 Gene

SOURCE GeneReport for Unigene cluster for NANOS2 Gene Hs.434218

mRNA Expression by UniProt/SwissProt for NANOS2 Gene

P60321-NANO2_HUMAN
Tissue specificity: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
genes like me logo Genes that share expressions with NANOS2: view

In Situ Assay Products

Orthologs for NANOS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS2 35
  • 99.03 (n)
  • 100 (a)
NANOS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NANOS2 35
  • 85.99 (n)
  • 86.96 (a)
NANOS2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANOS2 35
  • 85.27 (n)
  • 84.06 (a)
NANOS2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nanos2 35
  • 75.49 (n)
  • 76.47 (a)
Nanos2 16
Nanos2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nanos2 35
  • 75 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nos 36
  • 9 (a)
OneToMany
Species with no ortholog for NANOS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOS2 Gene

ENSEMBL:
Gene Tree for NANOS2 (if available)
TreeFam:
Gene Tree for NANOS2 (if available)

Paralogs for NANOS2 Gene

Paralogs for NANOS2 Gene

Selected SIMAP similar genes for NANOS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS2: view

Variants for NANOS2 Gene

Sequence variations from dbSNP and Humsavar for NANOS2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs888950 -- 45,914,831(+) CTAAG(C/T)AAAGG upstream-variant-2KB
rs888952 -- 45,915,836(+) agaga(A/G)tcact upstream-variant-2KB
rs1422627 -- 45,913,480(+) TCGGA(C/T)GGGAG utr-variant-3-prime
rs2015728 -- 45,915,628(+) atgaa(G/T)cttgg upstream-variant-2KB
rs3051355 -- 45,915,454(-) aaaat(-/AA)aaaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NANOS2 Gene

Variant ID Type Subtype PubMed ID
nsv510770 CNV Loss 20534489
nsv2507 CNV Insertion 18451855

Relevant External Links for NANOS2 Gene

HapMap Linkage Disequilibrium report
NANOS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS2 Gene

Disorders for NANOS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NANOS2 Gene including...

Search for NANOS2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NANOS2 Gene

genes like me logo Genes that share disorders with NANOS2: view

No data available for UniProtKB/Swiss-Prot for NANOS2 Gene

Publications for NANOS2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. (PMID: 19168545) Kusz K.M. … Jaruzelska J. (Mol. Hum. Reprod. 2009) 3 4
  3. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J. … Reijo Pera R.A. (Dev. Genes Evol. 2003) 2 3
  4. Conserved role of nanos proteins in germ cell development. (PMID: 12947200) Tsuda M. … Saga Y. (Science 2003) 2 3
  5. Expression of nitric oxide synthases in keratinocytes after UVB irradiation. (PMID: 14615895) Chang H.R. … Yu H.S. (Arch. Dermatol. Res. 2003) 3

Products for NANOS2 Gene

Sources for NANOS2 Gene

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