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NANOS2 Gene

protein-coding GIFtS: 47

GC19M051108

nanos homolog 2 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
NOS2 ^¹, ², ³

Descriptions
nanos homolog 2 ^²
nanos homolog 2 (Drosophila) ^²

External Ids
HGNC: 23292¹
Entrez Gene: 339345²
UniProtKB: P60321³
Ensembl: ENSG00000188425⁷

Search outside databases for aliases for NANOS2 gene

Previous GC identifer: GC19U900395

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Function: Required to support proliferation and self-renewal of proximal germ cells in males only.

Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets.

Essential for spermatogonia formation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NANOS2 gene

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

NANOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M051108: (about GC identifiers)

Start:	51,108,312 bp from pter
End:	51,109,876 bp from pter
Size:	1,565 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321 (See protein sequence)

Recommended Name: Nanos homolog 2

Size: 138 amino acids; 15132 Da

Secondary accessions: Q17R30 Q4G0P8

REFSEQ proteins: NP_001025032.1

ENSEMBL proteins:

ENSP00000341021

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NANOS2)
	Human Recombinant Proteins from Abnova (NANOS2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for NANOS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NANOS2
	R&D Systems Antibodies for NANOS2
	Antibodies from Abcam (NANOS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NANOS2)
	Novus Biologicals Antibody for NANOS2

Assays for NANOS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P60321

ProtoNet protein and cluster: P60321

1 Blocks protein family: IPB008705 Nanos RNA-binding

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule

of zinc. It is essential for the translation repression activity of the protein (By similarity)

Similarity: Belongs to the nanos family

Similarity: Contains 1 nanos-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NANOS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NANOS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001029861

Applied Biosystems Silencer® siRNAs for NANOS2

Sigma-Aldrich siRNA for NANOS2

Sigma-Aldrich shRNA for NANOS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NANOS2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001029861
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001029861
untagged cDNA clone in CMV expression vector: NM_001029861

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001029861

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Function: Required to support proliferation and self-renewal of proximal germ cells in males only.

Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets.

Essential for spermatogonia formation (By similarity)

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nanos2):

endocrine/exocrine gland

no phenotypic analysis

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/38 Interacting proteins for NANOS2 (ENSP00000341021³) via UniProtKB, MINT, and/or STRING (see all 38 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL6	ENSP00000258743³	STRING (score=.919)
IFNG	ENSP00000229135³	STRING (score=.917)
IL1B	ENSP00000263341³	STRING (score=.915)
IL4	ENSP00000231449³	STRING (score=.913)
PTGS2	ENSP00000356438³	STRING (score=.908)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006417	regulation of translation	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007283	spermatogenesis	IEA	--
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NANOS2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NANOS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NANOS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001029861

Sigma-Aldrich siRNA for NANOS2

Sigma-Aldrich shRNA for NANOS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001029861

REFSEQ mRNAs for NANOS2 gene:

NM_001029861.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001029861

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001029861
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001029861
                                 untagged cDNA clone in CMV expression vector: NM_001029861

Additional cDNA sequence:

BC042883.1 BC117484.1 BC117486.1

1 DOTS entry:

DT.95361109

3 AceView cDNA sequences:

BC042883 BI826677 BI463423

highest scoring ESTs for NANOS2:

BC042883 BI463423 BI826677 BC117484 BC117486 NM_001029861 XM_371181

Unigene Cluster for NANOS2:

Nanos homolog 2 (Drosophila)

Hs.434218 [show with all ESTs]

Unigene Representative Sequence: BC042883

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000341294

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NANOS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NANOS2

¹ / ²

1 probe-set matching NANOS2 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1557767_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATCTTTTGT

SOURCE GeneReport for Unigene cluster: Hs.434218

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NANOS2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NANOS2¹	--	nanos homolog 2 (Drosophila)	85.27(n) 84.06(a)	484432 XM_541547.1 XP_541547.1
chimpanzee (Pan troglodytes)	NANOS2¹	--	nanos homolog 2 (Drosophila)	99.03(n) 100(a)	745748 XM_001167172.1 XP_001167172.1
rat (Rattus norvegicus)	Nanos2¹	--	nanos homolog 2 (Drosophila)	75(n) 75(a)	365213 XM_344868.3 XP_344869.2
mouse (Mus musculus)	Nanos2^{1, 5}	7⁵	nanos homolog 2 (Drosophila)^{1, 5}	75.56(n)¹ 77.78(a)¹	378430¹ NM_194064.1¹ NP_918953.1¹ AB095972⁵ BC160381⁵

About this table Species with no ortholog for NANOS2

ENSEMBL Gene Tree for NANOS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NANOS2 gene

NANOS3² NANOS1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/23 NCBI SNPs in NANOS2 are shown (see all 23 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 20)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs888950^1,2	A,C,F,H,O	51109929(+)	`CTAAGC/TAAAGG`	1	--	ng3¹		13		MN EU EA WA NA	1236
	rs2015728^1,2	A,C,F,H	51110726(+)	`atgaaG/Tcttgg`	1	--	ng3¹		8		EU EA WA	836
	rs9304651^1,2	A,C,F,H	51111613(+)	`AACACA/GTAGTT`	1	--	ng3¹		12		EU EA WA NA	1054
	rs1422627^1,2	C,F,H,O	51108578(+)	`TCGGAT/CGGGAG`	1	--	ut3¹		8		NA EA MN EU WA	844
	rs8111011^1,2	A,C,F,H	51108487(+)	`TTATCA/GGCGGT`	1	--	ut3¹		7		EU EA WA NA	550
--	rs888952^1,2	A,C	51110934(+)	`agagaA/Gtcact`	1	--	ng3¹		0	--	--	--	--
--	rs12460313^1,2	A,C	51111287(+)	`attacA/Gggtgc`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs8108544^1,2	A	51111293(+)	`ggtgcA/Ccacca`	1	--	ng3¹		0	--	--	--	--
--	rs35756017^1,2	--	51108107(+)	`CGACA-/ACAGCAA`	1	--	ng5¹		0	--	--	--	--
--	rs5828254^1,2	--	51109132(+)	`GAAGG-/GTTCCC`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NANOS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608228

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for NANOS2 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Conserved role of nanos proteins in germ cell development. (PubMed id 12947200)^{2, 3} Tsuda M....Saga Y. (2003)
Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PubMed id 12690449)^{2, 3} Jaruzelska J....Reijo Pera R.A. (2003)
The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. (PubMed id 19168545)³ Kusz K.M....Jaruzelska J. (2009)
Expression of nitric oxide synthases in keratinocytes after UVB irradiation. (PubMed id 14615895)³ Chang H.R....Yu H.S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 339345	HGNC: 23292	AceView: NANOS2	Ensembl:ENSG00000188425	euGenes: HUgn339345
ECgene: NANOS2	H-InvDB: NANOS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NANOS2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NANOS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NANOS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NANOS2		Antibodies for NANOS2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NANOS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NANOS2)
	Antibodies (NANOS2)
	Chimera RNAi (NANOS2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (NANOS2)
	Antibodies (NANOS2)

Search OriGene for NANOS2

Search Tocris compounds for NANOS2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NANOS2

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NANOS2 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for NANOS2

Summaries
for NANOS2

Genomic Location
for NANOS2

Proteins
for NANOS2

Protein Domains/
Families
for NANOS2

Gene Function
for NANOS2

Pathways & Interactions
for NANOS2

Drugs & Compounds
for NANOS2

Transcripts
for NANOS2

Expression
for NANOS2

Orthologs
for NANOS2

Paralogs
for NANOS2

SNPs/Variants
for NANOS2

Disorders & Mutations
for NANOS2

Medical News
for NANOS2

Publications
for NANOS2

Search for NANOS2

Genome Databases showing NANOS2

Other Databases showing NANOS2

Specialized Databases showing NANOS2

Licensable Technologies
for NANOS2

Services
for NANOS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NANOS2 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor NANOS2

Summariesfor NANOS2

Genomic Locationfor NANOS2

Proteinsfor NANOS2

Protein Domains/Familiesfor NANOS2

Gene Functionfor NANOS2

Pathways & Interactionsfor NANOS2

Drugs & Compoundsfor NANOS2

Transcriptsfor NANOS2

Expression for NANOS2

Orthologsfor NANOS2

Paralogsfor NANOS2

SNPs/Variantsfor NANOS2

Disorders & Mutationsfor NANOS2

Medical Newsfor NANOS2

Publicationsfor NANOS2

Search for NANOS2

Genome Databases showing NANOS2

Other Databases showing NANOS2

Specialized Databases showing NANOS2

Licensable Technologiesfor NANOS2

Servicesfor NANOS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NANOS2

Summaries
for NANOS2

Genomic Location
for NANOS2

Proteins
for NANOS2

Protein Domains/
Families
for NANOS2

Gene Function
for NANOS2

Pathways & Interactions
for NANOS2

Drugs & Compounds
for NANOS2

Transcripts
for NANOS2

Expression
for NANOS2

Orthologs
for NANOS2

Paralogs
for NANOS2

SNPs/Variants
for NANOS2

Disorders & Mutations
for NANOS2

Medical News
for NANOS2

Publications
for NANOS2

Licensable Technologies
for NANOS2

Services
for NANOS2