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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NANOS2 Gene

protein-coding GIFtS: 47
GCID: GC19M046416

nanos homolog 2 (Drosophila)

Explore 1 disease affiliated with
NANOS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nanos Homolog 2 (Drosophila)¹ ²
NOS2¹ ² ³
NOS-2² ³
Nanos Homolog 2²

External Ids:	HGNC: 23292¹	Entrez Gene: 339345²	Ensembl: ENSG00000188425⁷	OMIM: 608228⁵	UniProtKB: P60321³

Export aliases for NANOS2 gene to outside databases

Previous GC identifers: GC19U900395 GC19M051108 GC19M042844

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Function: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the

female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the

male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA

replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies

and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the

maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for

the maintenance of their normal state (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NANOS2 gene promoter:
Tal-1 NRSF form 1 Lmo2 XBP-1 NRSF form 2 E47 Max FOXO4 COMP1 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NANOS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

NANOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOS2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M046416: view genomic region (about GC identifiers)

Start:	46,416,472 bp from pter	End:	46,418,036 bp from pter
Size:	1,565 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321 (See protein sequence)

Recommended Name: Nanos homolog 2

Size: 138 amino acids; 15132 Da

Subunit: Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 (By similarity)

Subcellular location: Cytoplasm. Cytoplasm, P-body (By similarity). Cytoplasm, perinuclear region. Note=Localizes at

P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ

cells of the adult testis

Developmental stage: Fetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week

fetus (at protein level)

Secondary accessions: Q17R30 Q4G0P8

Explore the universe of human proteins at neXtProt for NANOS2: NX_P60321

NANOS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001025032.1

ENSEMBL proteins:

ENSP00000341021

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NANOS2 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for NANOS2
	GenScript Custom Purified and Recombinant Proteins Services for NANOS2
	Novus Biologicals NANOS2 Proteins Novus Biologicals NANOS2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NANOS2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000932	cytoplasmic mRNA processing body	ISS	--
GO:0005737	cytoplasm	IDA	19168545
GO:0048471	perinuclear region of cytoplasm	IDA	19168545

NANOS2 for ontologies About GeneDecksing

NANOS2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NANOS2
	R&D Systems Antibodies for NANOS2
	OriGene Antibodies (see all 2): NANOS2 OriGene Custom Antibody Services for NANOS2
	GenScript Custom Superior Antibodies Services for NANOS2
	Novus Biologicals NANOS2 Antibodies
	Search for Antibodies for NANOS2 at Abcam
	Uscn Antibodies for NANOS2
	ThermoFisher Antibodies for NANOS2

Assay Products for NANOS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NANOS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NANOS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NANOS2 for domains About GeneDecksing

2 InterPro domains/families:

IPR024161 Znf_nanos-typ

IPR008705 Nanos/Xcar2

Graphical View of Domain Structure for InterPro Entry P60321

ProtoNet protein and cluster: P60321

1 Blocks protein family: IPB008705 Nanos RNA-binding

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is

essential for the translation repression activity of the protein (By similarity)

Similarity: Belongs to the nanos family

Similarity: Contains 1 nanos-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Function: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the

female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the

male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA

replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies

and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the

maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for

the maintenance of their normal state (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANOS2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate NANOS2:
		hsa-miR-1226
		SwitchGear 3'UTR luciferase reporter plasmid: NANOS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NANOS2 (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NANOS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NANOS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NANOS2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NANOS2 (NM_001029861)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NANOS2
		Search LifeMap BioReagents cell lines for NANOS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--

NANOS2 for ontologies About GeneDecksing

Animal Models:
4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nanos2):

cellular

endocrine/exocrine gland

no phenotypic analysis

reproductive system

NANOS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NANOS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for NANOS2 (ENSP00000341021⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RQCD1	ENSP00000273064⁴	STRING: ENSP00000273064
CNOT1	ENSP00000320949⁴	STRING: ENSP00000320949
CNOT3	ENSP00000221232⁴	STRING: ENSP00000221232
CNOT7	ENSP00000355279⁴	STRING: ENSP00000355279
CNOT6L	ENSP00000264903⁴	STRING: ENSP00000264903

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006402	mRNA catabolic process	ISS	--
GO:0006417	regulation of translation	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007283	spermatogenesis	ISS	--
GO:0030718	germ-line stem cell maintenance	ISS	--

NANOS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for NANOS2 available from Tocris Bioscience About this table

Compound	Action	CAS #
BYK 191023 dihydrochloride	Potent and selective inhibitor of iNOS	[608880-48-4]
AR-C 102222	Selective iNOS inhibitor	[253771-21-0]
L-NIL hydrochloride	Selective iNOS inhibitor	[150403-89-7]
L-Canavanine sulfate	NOS inhibitor	[2219-31-0]
1400W dihydrochloride	Potent, highly selective iNOS inhibitor	[180001-34-7]

Search CenterWatch for drugs/clinical trials and news about NANOS2 / NANO2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NANOS2 gene:

NM_001029861.2

Unigene Cluster for NANOS2:

Nanos homolog 2 (Drosophila)

Hs.434218 [show with all ESTs]

Unigene Representative Sequence: BC042883

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000341294(uc002pdu.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANOS2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate NANOS2:
		hsa-miR-1226
		SwitchGear 3'UTR luciferase reporter plasmid: NANOS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NANOS2 (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOS2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NANOS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NANOS2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NANOS2 (NM_001029861)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NANOS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NANOS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOS2

Additional cDNA sequence:

BC042883.1 BC117484.1 BC117486.1

1 DOTS entry:

DT.95361109

3 AceView cDNA sequences:

BC042883 BI826677 BI463423

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NANOS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCTTTTGT

About this image

NANOS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatogonial Stem Cells

Selective marker (cell-identifying gene)

Germ Cells, Male Gametocytes

Testis

Testis Cord

XY Germ Cells

Germ Cells, Male Gametocytes

Testis

Seminiferous Tubules

Spermatogonium Type A

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NANOS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NANOS2

SOURCE GeneReport for Unigene cluster: Hs.434218

UniProtKB/Swiss-Prot: NANO2_HUMAN, P60321

Tissue specificity: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of

the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level)

SABiosciences Custom PCR Arrays for NANOS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NANOS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NANOS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NANOS2 gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nanos2^{1 , 5}	nanos homolog 2 (Drosophila)^{1, 5}	75.56(n)¹ 77.78(a)¹		7 (9.45 cM)⁵ 378430¹ NM_194064.2¹ NP_918953.2¹ 18987524⁵
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 68)	--	57(a) 57(a) (see all 68)	many → 1 many → 1 (see all 68)	GL343215.1(96034-96510) 1(141249941-141252593)

ENSEMBL Gene Tree for NANOS2 (if available)
TreeFam Gene Tree for NANOS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NANOS2 gene

NANOS3² NANOS1²

2 SIMAP similar genes for NANOS2 using alignment to 1 protein entry: NANO2_HUMAN:

NANOS1 NANOS3

NANOS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113938413^1,2		--	46416037(+)	`AAGAAA/GAAACA`	1	--	int¹		2		CSA EA	122
rs192707159^1,2		--	46416120(+)	`CTACTA/GAAAAT`	1	--	int¹		0	--	--	--	--
rs143171048^1,2		--	46416152(+)	`GGTGCA/CTGTCT`	1	--	int¹		0	--	--	--	--
rs117803189^1,2	F,	--	46416176(+)	`CTCCGG/AAGGCT`	1	--	int¹		1		EA	120
rs145530568^1,2	C,	--	46416266(+)	`CGACA-/ACAGCAA`	1	--	int¹		0	--	--	--	--
rs11384530^1,2	C	--	46416284(+)	`AAAAAA/-TTAGC`	1	--	int¹		1		NA	2
rs185063453^1,2		--	46416321(+)	`GGGGCA/GCACCT`	1	--	int¹		0	--	--	--	--
rs147508361^1,2		--	46416454(+)	`AAAGAC/TGGAAA`	1	--	int¹		0	--	--	--	--
rs189526828^1,2		--	46416577(+)	`CTTCTA/TCTCTT`	1	--	ut3¹		0	--	--	--	--
rs114645466^1,2		--	46416629(+)	`GGTACT/CCAAAC`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for NANOS2 (46416472 - 46418036 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NANOS2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NANOS2

DNA2.0 Custom Variant and Variant Library Synthesis for NANOS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NANOS2 for disorders           About GeneDecksing

OMIM gene information: 608228    OMIM disorders: --

1 disease for NANOS2:    About MalaCards

teratoma

1 disease from the University of Copenhagen DISEASES database for NANOS2:

Spermatocytoma

Export disorders for NANOS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NANOS2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NANOS2)

Utopia: connect your pdf to the dynamic
world of online information

The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. (PubMed id 19168545)^{1, 2} Kusz K.M....Jaruzelska J. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Conserved role of nanos proteins in germ cell development. (PubMed id 12947200)^{1, 3} Tsuda M....Saga Y. (2003)
Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PubMed id 12690449)^{1, 3} Jaruzelska J....Reijo Pera R.A. (2003)
NANOS3 function in human germ cell development. (PubMed id 21421998)² Julaton V.T. and Reijo Pera R.A. (2011)
Expression of nitric oxide synthases in keratinocytes after UVB irradiation. (PubMed id 14615895)¹ Chang H.R....Yu H.S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 339345	HGNC: 23292	AceView: NANOS2	Ensembl:ENSG00000188425	euGenes: HUgn339345
ECgene: NANOS2	H-InvDB: NANOS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NANOS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NANOS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NANOS2 gene:
Search GeneIP for patents involving NANOS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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	Antibodies for NANOS2 (Nanos2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
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	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
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	OriGene Antibodies for NANOS2		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NANOS2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NANOS2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NANOS2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NANOS2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for NANOS2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NANOS2		OriGene Custom Protein Services for NANOS2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NANOS2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NANOS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOS2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOS2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOS2

	GenScript Custom Purified and Recombinant Proteins Services for NANOS2		GenScript cDNA clones with any tag delivered in your preferred vector for NANOS2
	GenScript Custom Assay Services for NANOS2		GenScript Custom Superior Antibodies Services for NANOS2
	GenScript Custom overexpressing Cell Line Services for NANOS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in NANOS2 promoter
	Search Chromatin IP Primers for NANOS2
	RT² qPCR Primer Assay in human, mouse, rat NANOS2
	Search GNC Networks for NANOS2
	SABiosciences Custom PCR Arrays for NANOS2

Tocris compounds for NANOS2

	Browse Sino Biological Proteins and Antibodies
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	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NANOS2 antibodies
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	Search for Antibodies for NANOS2 at Abcam
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	Custom Antibody / Protein Production Service
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Browse ProSpec Recombinant Proteins

NANOS2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NANOS2

	Gene Synthesis
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	Codon Optimization
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS2

	SwitchGear 3'UTR luciferase reporter plasmids for NANOS2
	Browse SwitchGear Promoter luciferase reporter plasmids for NANOS2

ThermoFisher Antibodies for NANOS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NANOS2 Gene

nanos homolog 2 (Drosophila)

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NANOS2 Gene

nanos homolog 2 (Drosophila)

Aliasesfor NANOS2 gene

Summariesfor NANOS2 gene

Genomic Viewsfor NANOS2 gene

Proteinsfor NANOS2 gene

Protein Domains /Familiesfor NANOS2 gene

Functionfor NANOS2 gene

Pathways & Interactionsfor NANOS2 gene

Drugs & Compoundsfor NANOS2 gene

Transcriptsfor NANOS2 gene

Expression for NANOS2 gene

Orthologsfor NANOS2 gene

Paralogsfor NANOS2 gene

Genomic Variantsfor NANOS2 gene

Disorders / Diseasesfor NANOS2 gene

Publicationsfor NANOS2 gene

External Searches for NANOS2 gene

Genome Databases showing NANOS2 gene

Other Databases showing NANOS2 gene

Specialized Databases showing NANOS2 gene

Intellectual Propertyfor NANOS2 gene

Productsfor NANOS2 gene

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Aliases
for NANOS2 gene

Summaries
for NANOS2 gene

Genomic Views
for NANOS2 gene

Proteins
for NANOS2 gene

Protein Domains /
Families
for NANOS2 gene

Function
for NANOS2 gene

Pathways & Interactions
for NANOS2 gene

Drugs & Compounds
for NANOS2 gene

Transcripts
for NANOS2 gene

Expression
for NANOS2 gene

Orthologs
for NANOS2 gene

Paralogs
for NANOS2 gene

Genomic Variants
for NANOS2 gene

Disorders / Diseases
for NANOS2 gene

Publications
for NANOS2 gene

Intellectual Property
for NANOS2 gene

Products
for NANOS2 gene