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Aliases for NANOS1 Gene

Aliases for NANOS1 Gene

  • Nanos Homolog 1 (Drosophila) 2 3 5
  • EC_Rep1a 3 4
  • NOS-1 3 4
  • NOS1 3 4
  • SPGF12 3

External Ids for NANOS1 Gene

Previous GeneCards Identifiers for NANOS1 Gene

  • GC10U900443
  • GC10P120453
  • GC10P120779
  • GC10P114419

Summaries for NANOS1 Gene

Entrez Gene Summary for NANOS1 Gene

  • This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

GeneCards Summary for NANOS1 Gene

NANOS1 (Nanos Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with NANOS1 include Spermatogenic Failure 12. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot for NANOS1 Gene

  • May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS1 Gene

Genomics for NANOS1 Gene

Regulatory Elements for NANOS1 Gene

Enhancers for NANOS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NANOS1 on UCSC Golden Path with GeneCards custom track

Promoters for NANOS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NANOS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NANOS1 Gene

Chromosome:
10
Start:
119,029,716 bp from pter
End:
119,034,342 bp from pter
Size:
4,627 bases
Orientation:
Plus strand

Genomic View for NANOS1 Gene

Genes around NANOS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS1 Gene

Proteins for NANOS1 Gene

  • Protein details for NANOS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY41-NANO1_HUMAN
    Recommended name:
    Nanos homolog 1
    Protein Accession:
    Q8WY41

    Protein attributes for NANOS1 Gene

    Size:
    292 amino acids
    Molecular mass:
    30230 Da
    Quaternary structure:
    • Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Interacts with DDX20 (via N-terminal region).

    Three dimensional structures from OCA and Proteopedia for NANOS1 Gene

neXtProt entry for NANOS1 Gene

Proteomics data for NANOS1 Gene at MOPED

Post-translational modifications for NANOS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NANOS1 Gene

Domains & Families for NANOS1 Gene

Protein Domains for NANOS1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY41

UniProtKB/Swiss-Prot:

NANO1_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
  • Contains 1 nanos-type zinc finger.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
Family:
  • Belongs to the nanos family.
Similarity:
  • Contains 1 nanos-type zinc finger.
genes like me logo Genes that share domains with NANOS1: view

No data available for Gene Families for NANOS1 Gene

Function for NANOS1 Gene

Molecular function for NANOS1 Gene

UniProtKB/Swiss-Prot Function:
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
UniProtKB/Swiss-Prot Induction:
Down-regulated by E-cadherin.

Gene Ontology (GO) - Molecular Function for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17047063
genes like me logo Genes that share ontologies with NANOS1: view
genes like me logo Genes that share phenotypes with NANOS1: view

Human Phenotype Ontology for NANOS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NANOS1 Gene

MGI Knock Outs for NANOS1:

Animal Model Products

miRNA for NANOS1 Gene

miRTarBase miRNAs that target NANOS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NANOS1 Gene

Localization for NANOS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS1 Gene

Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269 PubMed:12690449, ECO:0000269 PubMed:19168546}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOS1 Gene COMPARTMENTS Subcellular localization image for NANOS1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NANOS1 Gene

Pathways & Interactions for NANOS1 Gene

SuperPathways for NANOS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010631 epithelial cell migration IDA 17047063
GO:0016477 cell migration IDA 18223680
genes like me logo Genes that share ontologies with NANOS1: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS1 Gene

Drugs & Compounds for NANOS1 Gene

(1) Drugs for NANOS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NANOS1: view

Transcripts for NANOS1 Gene

mRNA/cDNA for NANOS1 Gene

Unigene Clusters for NANOS1 Gene

Nanos homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS1 Gene

No ASD Table

Relevant External Links for NANOS1 Gene

GeneLoc Exon Structure for
NANOS1
ECgene alternative splicing isoforms for
NANOS1

Expression for NANOS1 Gene

mRNA expression in normal human tissues for NANOS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.9).

SOURCE GeneReport for Unigene cluster for NANOS1 Gene Hs.591918

mRNA Expression by UniProt/SwissProt for NANOS1 Gene

Q8WY41-NANO1_HUMAN
Tissue specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
genes like me logo Genes that share expression patterns with NANOS1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NANOS1 Gene

Orthologs for NANOS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NANOS1 35
  • 93.15 (n)
  • 96.43 (a)
dog
(Canis familiaris)
Mammalia NANOS1 35
  • 94.68 (n)
  • 94.44 (a)
NANOS1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nanos1 35
  • 84.6 (n)
  • 84.09 (a)
Nanos1 16
Nanos1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nanos1 35
  • 84.86 (n)
  • 84.73 (a)
oppossum
(Monodelphis domestica)
Mammalia NANOS1 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NANOS1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NANOS1 35
  • 71.49 (n)
  • 60.96 (a)
NANOS1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NANOS1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Xcat-2 35
African clawed frog
(Xenopus laevis)
Amphibia Xcat-2 35
zebrafish
(Danio rerio)
Actinopterygii nanos1 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nos 36
  • 13 (a)
OneToMany
Species with no ortholog for NANOS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS1 Gene

ENSEMBL:
Gene Tree for NANOS1 (if available)
TreeFam:
Gene Tree for NANOS1 (if available)

Paralogs for NANOS1 Gene

Paralogs for NANOS1 Gene

(2) SIMAP similar genes for NANOS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NANOS1: view

Variants for NANOS1 Gene

Sequence variations from dbSNP and Humsavar for NANOS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs191267549 - 119,029,901(+) CGGGC(A/C)CGGCG reference, missense
VAR_070572 -
VAR_070573 -
rs1500986 -- 119,029,035(-) GGCTT(C/T)CGTTT upstream-variant-2KB
rs3061097 -- 119,033,873(+) TGGTT(-/A)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NANOS1 Gene

Variant ID Type Subtype PubMed ID
nsv825582 CNV Gain 20364138

Variation tolerance for NANOS1 Gene

Gene Damage Index Score: 3.16; 51.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOS1 Gene

Human Gene Mutation Database (HGMD)
NANOS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS1 Gene

Disorders for NANOS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NANOS1 Gene - From: OMIM, ClinVar, GeneTests, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 12
  • spgf12
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NANO1_HUMAN
  • Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. {ECO:0000269 PubMed:23315541}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NANOS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOS1
genes like me logo Genes that share disorders with NANOS1: view

No data available for Genatlas for NANOS1 Gene

Publications for NANOS1 Gene

  1. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J. … Reijo Pera R.A. (Dev. Genes Evol. 2003) 2 3 4 23 67
  2. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. (PMID: 24736845) Bhandari D. … Izaurralde E. (Genes Dev. 2014) 3
  3. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. (PMID: 25100735) Miles W.O. … Dyson N.J. (EMBO J. 2014) 3
  4. Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo- astheno-teratozoospermia. (PMID: 23315541) Kusz-Zamelczyk K. … Jaruzelska J. (J. Med. Genet. 2013) 3
  5. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. (PMID: 23320086) Lu C. … Wang X. (PLoS ONE 2013) 3

Products for NANOS1 Gene

Sources for NANOS1 Gene

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