External Ids for NANOS1 Gene
Previous GeneCards Identifiers for NANOS1 Gene
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
GeneCards Summary for NANOS1 Gene
NANOS1 (Nanos Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with NANOS1 include spermatogenic failure 12. Among its related pathways are Immune System and PEDF Induced Signaling. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS3.
UniProtKB/Swiss-Prot for NANOS1 Gene
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.