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Aliases for NANOS1 Gene

Aliases for NANOS1 Gene

  • Nanos Homolog 1 (Drosophila) 2 3
  • NOS1 3 4 6
  • EC_Rep1a 3 4
  • SPGF12 3 6
  • NOS-1 3 4
  • Nanos Homolog 1 3

External Ids for NANOS1 Gene

Previous GeneCards Identifiers for NANOS1 Gene

  • GC10U900443
  • GC10P120453
  • GC10P120779
  • GC10P114419

Summaries for NANOS1 Gene

GeneCards Summary for NANOS1 Gene

NANOS1 (Nanos Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with NANOS1 include spermatogenic failure 12 and atherosclerosis. Among its related pathways are Disease and PEDF Induced Signaling. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot for NANOS1 Gene

  • May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS1 Gene

Genomics for NANOS1 Gene

Regulatory Elements for NANOS1 Gene

Genomic Location for NANOS1 Gene

119,029,716 bp from pter
119,034,342 bp from pter
4,627 bases
Plus strand

Genomic View for NANOS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NANOS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS1 Gene

Proteins for NANOS1 Gene

  • Protein details for NANOS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nanos homolog 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for NANOS1 Gene

    292 amino acids
    Molecular mass:
    30230 Da
    Quaternary structure:
    • Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Interacts with DDX20 (via N-terminal region).

    Three dimensional structures from OCA and Proteopedia for NANOS1 Gene

neXtProt entry for NANOS1 Gene

Proteomics data for NANOS1 Gene at MOPED

Post-translational modifications for NANOS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS1 Gene

Domains for NANOS1 Gene

Protein Domains for NANOS1 Gene


Suggested Antigen Peptide Sequences for NANOS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WY41
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN
  • Belongs to the nanos family.
  • Contains 1 nanos-type zinc finger.
genes like me logo Genes that share domains with NANOS1: view

No data available for Gene Families for NANOS1 Gene

Function for NANOS1 Gene

Molecular function for NANOS1 Gene

UniProtKB/Swiss-Prot Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
UniProtKB/Swiss-Prot Induction: Down-regulated by E-cadherin.

Gene Ontology (GO) - Molecular Function for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17047063
GO:0008270 zinc ion binding IEA --
GO:0030371 translation repressor activity ISS --
genes like me logo Genes that share ontologies with NANOS1: view

Phenotypes for NANOS1 Gene

MGI mutant phenotypes for NANOS1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NANOS1: view

miRNA for NANOS1 Gene

miRTarBase miRNAs that target NANOS1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NANOS1 Gene

Localization for NANOS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS1 Gene

Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.

Subcellular locations from

Jensen Localization Image for NANOS1 Gene COMPARTMENTS Subcellular localization image for NANOS1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12690449
GO:0048471 perinuclear region of cytoplasm IDA 17047063
genes like me logo Genes that share ontologies with NANOS1: view

Pathways for NANOS1 Gene

genes like me logo Genes that share pathways with NANOS1: view

Gene Ontology (GO) - Biological Process for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010631 epithelial cell migration IDA 17047063
GO:0016477 cell migration IDA 18223680
GO:0017148 negative regulation of translation IDA 24736845
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA 24736845
genes like me logo Genes that share ontologies with NANOS1: view

Compounds for NANOS1 Gene

(1) Novoseek inferred chemical compound relationships for NANOS1 Gene

Compound -log(P) Hits PubMed IDs
nitric oxide 35.1 1
genes like me logo Genes that share compounds with NANOS1: view

Transcripts for NANOS1 Gene

mRNA/cDNA for NANOS1 Gene

(66) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS1 Gene

Nanos homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS1 Gene

No ASD Table

Relevant External Links for NANOS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NANOS1 Gene

mRNA expression in normal human tissues for NANOS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS1 Gene

This gene is overexpressed in Muscle - Skeletal (4.9).

SOURCE GeneReport for Unigene cluster for NANOS1 Gene Hs.591918

mRNA Expression by UniProt/SwissProt for NANOS1 Gene

Tissue specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
genes like me logo Genes that share expressions with NANOS1: view

No data available for Protein expression for NANOS1 Gene

Orthologs for NANOS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NANOS1 36
  • 74 (a)
(Bos Taurus)
Mammalia NANOS1 35
  • 93.15 (n)
  • 96.43 (a)
(Canis familiaris)
Mammalia NANOS1 35
  • 94.68 (n)
  • 94.44 (a)
  • 83 (a)
(Mus musculus)
Mammalia Nanos1 35
  • 84.6 (n)
  • 84.09 (a)
Nanos1 16
Nanos1 36
  • 79 (a)
(Monodelphis domestica)
Mammalia NANOS1 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Nanos1 35
  • 84.86 (n)
  • 84.73 (a)
(Gallus gallus)
Aves NANOS1 35
  • 71.49 (n)
  • 60.96 (a)
  • 47 (a)
(Anolis carolinensis)
Reptilia NANOS1 36
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xcat-2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Xcat-2 35
(Danio rerio)
Actinopterygii nanos1 36
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta nos 36
  • 13 (a)
Species with no ortholog for NANOS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS1 Gene

Gene Tree for NANOS1 (if available)
Gene Tree for NANOS1 (if available)

Paralogs for NANOS1 Gene

Paralogs for NANOS1 Gene

Selected SIMAP similar genes for NANOS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NANOS1: view

Variants for NANOS1 Gene

Sequence variations from dbSNP and Humsavar for NANOS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs546753 -- 119,033,172(-) GTTGC(C/T)CAGGC utr-variant-3-prime
rs546808 -- 119,033,191(-) TTGGA(G/T)ACAGA utr-variant-3-prime
rs614465 -- 119,031,548(+) TTGGC(A/C)TTTTC utr-variant-3-prime
rs1061366 -- 119,034,496(-) AAGGA(C/T)TTTTC downstream-variant-500B
rs3061097 -- 119,033,873(+) TGGTT(-/A)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NANOS1 Gene

Variant ID Type Subtype PubMed ID
nsv825582 CNV Gain 20364138

Relevant External Links for NANOS1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS1 Gene

Disorders for NANOS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NANOS1 Gene including...

Search for NANOS1 Gene in MalaCards »

(1) OMIM Diseases for NANOS1 Gene (608226)


  • Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. {ECO:0000269 PubMed:23315541}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NANOS1 Gene

genes like me logo Genes that share disorders with NANOS1: view

Publications for NANOS1 Gene

  1. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J. … Reijo Pera R.A. (Dev. Genes Evol. 2003) 2 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. (PMID: 17047063) Strumane K. … van Roy F. (Cancer Res. 2006) 3 4
  4. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PMID: 18223680) Bonnomet A. … Nawrocki-Raby B. (Oncogene 2008) 3 4
  5. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PMID: 19168546) Ginter-Matuszewska B. … Jaruzelska J. (Mol. Hum. Reprod. 2009) 3 4

Products for NANOS1 Gene

Sources for NANOS1 Gene

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