External Ids for NANOS1 Gene
Previous GeneCards Identifiers for NANOS1 Gene
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
GeneCards Summary for NANOS1 Gene
NANOS1 (Nanos Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with NANOS1 include spermatogenic failure 12. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS3.
UniProtKB/Swiss-Prot for NANOS1 Gene
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.