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Aliases & Descriptions for NANOS1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC_Rep1a 3 | | NOS-1 3 | | NOS1 1, 2, 3, 5 | | OTTHUMP00000046853 2 |
| | | Descriptions |
|---|
| nanos homolog 1 2 | | nanos homolog 1 (Drosophila) 2 |
|
| | Search outside databases for aliases for NANOS1 genePrevious GC identifers: GC10U900443 GC10P120453 |
Summaries for NANOS1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41Function: May regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets |
Genomic Location for NANOS1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NANOS1 gene 
Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.13NANOS1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P120779:
(about GC identifiers)
Start:
|
120,779,218 bp from pter |
End:
|
120,783,844 bp from pter |
Size:
|
4,627 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for NANOS1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41 (See
protein sequence)Recommended Name: Nanos homolog 1 Size: 292 amino acids; 30230 Da
Subunit: Interacts with PUM2
Subcellular location: Cytoplasm, perinuclear regionREFSEQ proteins: NP_955631.1
ENSEMBL proteins: ENSP00000345924
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for NANOS1: Assays for NANOS1: | Protein
Domains/ Families for NANOS1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8WY41
ProtoNet protein and cluster: Q8WY41 1 Blocks protein family: IPB008705 Nanos RNA-binding
UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein (By similarity)Similarity: Belongs to the nanos familySimilarity: Contains 1 nanos-type zinc finger | Gene Function for NANOS1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001009553
Applied Biosystems Silencer® siRNAs for NANOS1
Sigma-Aldrich siRNA for NANOS1  Sigma-Aldrich shRNA for NANOS1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_199461                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_199461                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001009553 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_199461
UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41Function: May regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Nanos1):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for NANOS1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for NANOS1 
5/19 Interacting proteins for NANOS1 (ENSP000003459243) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006417 | regulation of translation |
IEA | -- | About this table
|
Drugs & Compounds for NANOS1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NANOS1 1 Novoseek chemical compound relationship for NANOS1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nitric oxide |
35.95 |
1 |
8972893 (1) |
About this table
|
Transcripts for NANOS1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001009553
Sigma-Aldrich siRNA for NANOS1  Sigma-Aldrich shRNA for NANOS1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_199461 REFSEQ mRNAs for NANOS1 gene: NM_199461.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_199461               OriGene GFP tagged cDNA clone in CMV expression vector: NM_199461                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_199461                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001009553  Additional cDNA sequence: AF086393.1 AF275269.2 AF458985.1 4 DOTS entries: DT.419410 DT.100798858 DT.40302531 DT.92421843 24/66 AceView cDNA sequences (see all 66
):AI138906 AW340709 AI422817 AI572316 AI421274 BE467063 AI371014 AI090689 BX094286 AW134982 W79223 AW026179 AI273269 N30160 AF458985 AA989054 BE503548 AI188525 BF590809 BE218421 W07677 AW137865 NM_199461 BE467767
highest scoring ESTs for NANOS1:AA459718 AA461301 AA482971 AA832519 AA989054 AF086393 AF275269 AF458985 AI090689 AI138906 Unigene Cluster for NANOS1: Nanos homolog 1 (Drosophila) Hs.591918 [show with all ESTs]Unigene Representative Sequence: NM_199461
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000340087
|
Expression for NANOS1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NANOS1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NANOS1
1 / 2 / 3 5 probe-sets matching NANOS1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.591918
Expression variation in blood from EXPOLDB for NANOS1 UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41Tissue specificity: Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells |
Orthologs for NANOS1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NANOS1 gene from 5 species
About this table Species with no ortholog for NANOS1
ENSEMBL Gene Tree for NANOS1 | Paralogs for NANOS1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NANOS1 gene
- NANOS32 NANOS22
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for NANOS1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NANOS1 (up to first 250kb)
|
Disorders & Mutations for NANOS1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608226
|
Medical News for NANOS1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NANOS1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for NANOS1 gene: |
Search for NANOS1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NANOS1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NANOS1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NANOS1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NANOS1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NANOS1:

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| | | | Search Tocris compounds for NANOS1 |
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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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