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NANOS1 Gene

protein-coding   GIFtS: 50
GCID: GC10P120779

Nanos Homolog 1 (Drosophila)

  See NANOS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nanos Homolog 1 (Drosophila)1 2
NOS12 3 5
EC_Rep1a2 3
NOS-12 3
SPGF122 5
Nanos Homolog 12

External Ids:    HGNC: 230441   Entrez Gene: 3407192   Ensembl: ENSG000001886137   OMIM: 6082265   UniProtKB: Q8WY413   

Export aliases for NANOS1 gene to outside databases

Previous GC identifers: GC10U900443 GC10P120453 GC10P114419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NANOS1 Gene:
NANOS1 (nanos homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with NANOS1 include spermatogenic failure 12, and atherosclerosis. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex
with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and
anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion

summary for NANOS1 Gene:
Neuronal nitric oxide synthase (nNOS), along with inducible nitric oxide synthase (iNOS) and endothelial
nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and
molecular oxygen. It is activated at concentrations of calcium greater than 100 nM and requires co-factors
of tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity.
Transcriptional regulation of nNOS is very complex and the nNOS gene produces multiple mRNA transcripts
using alternate promoters, alternative splicing, cassette insertions/deletions, and varied sites for 3'-UTR
cleavage and polyadenylation. Some of these alterations lead to variation in amino acid sequence,
translating into nNOS isoforms with altered structural and functional properties. nNOS has been implicated
in a wide variety of physiological and pathological processes, including neurotransmission, neurotoxicity,
skeletal muscle contraction, sexual function, body fluid homeostasis and atherosclerosis. Consistent with
such wide involvement, nNOS is expressed in numerous tissues. The human gene encoding nNOS is localized to
chromosome 12q14.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NANOS1 gene promoter:
         TBP   Tal-1   C/EBPalpha   E47   Egr-2   HEN1   Pax-3   GATA-6   TFIID   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANOS1 promoter sequence
   Search Chromatin IP Primers for NANOS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANOS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.13

NANOS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOS1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P120779:  view genomic region     (about GC identifiers)

Start:
120,789,228 bp from pter      End:
120,793,854 bp from pter
Size:
4,627 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41 (See protein sequence)
Recommended Name: Nanos homolog 1  
Size: 292 amino acids; 30230 Da
Subunit: Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Interacts with
DDX20 (via N-terminal region)
Developmental stage: Fetal ovary and fetal testis (at protein level)

Explore the universe of human proteins at neXtProt for NANOS1: NX_Q8WY41

Explore proteomics data for NANOS1 at MOPED


See NANOS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_955631.1  
ENSEMBL proteins: 
 ENSP00000345924   ENSP00000393275  

NANOS1 Human Recombinant Protein Products:

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Novus Biologicals NANOS1 Proteins
Novus Biologicals NANOS1 Lysate
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Cloud-Clone Corp. Proteins for NANOS1

 
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antibodies-online proteins for NANOS1 (5 products) 

 
antibodies-online peptides for NANOS1

NANOS1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of NANOS1
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antibodies-online antibodies for NANOS1 (69 products) 

NANOS1 Assay Products:

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Cloud-Clone Corp. ELISAs for NANOS1
Cloud-Clone Corp. CLIAs for NANOS1
Search eBioscience for ELISAs for NANOS1 
antibodies-online kits for NANOS1 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR024161 Znf_nanos-typ
 IPR008705 Nanos/Xcar2

Graphical View of Domain Structure for InterPro Entry Q8WY41

ProtoNet protein and cluster: Q8WY41

1 Blocks protein domain: IPB008705 Nanos RNA-binding

UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is
essential for the translation repression activity of the protein (By similarity)
Domain: The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction
with SNAPIN
Similarity: Belongs to the nanos family
Similarity: Contains 1 nanos-type zinc finger


Find genes that share domains with NANOS1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NANO1_HUMAN, Q8WY41
Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex
with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and
anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion
Induction: Down-regulated by E-cadherin

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003723RNA binding IEA--
GO:0005515protein binding IPI17047063
GO:0008270zinc ion binding IEA--
GO:0030371translation repressor activity ISS--
     
Find genes that share ontologies with NANOS1           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nanos1):
 normal 

Find genes that share phenotypes with NANOS1           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NANOS1

miRNA
Products:
    
miRTarBase miRNAs that target NANOS1:
hsa-mir-744-5p (MIRT037712)

Block miRNA regulation of human, mouse, rat NANOS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NANOS1 (see all 60):
hsa-miR-549 hsa-miR-520f hsa-miR-136 hsa-miR-429 hsa-miR-4328 hsa-miR-106a hsa-miR-29a hsa-miR-4305
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat NANOS1

Gene Editing
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OriGene clones in human, mouse for NANOS1 (see all 8)
OriGene ORF clones in mouse, rat for NANOS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NANOS1 (NM_199461)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS1

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NANO1_HUMAN, Q8WY41: Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the
perinuclear region of germ cells
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus3
mitochondrion2
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA12690449
GO:0048471perinuclear region of cytoplasm IDA17047063

Find genes that share ontologies with NANOS1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NANOS1 (see all 9)
    Cellular Effects of Sildenafil
Muscular Dystrophies and Dystrophin-Glycoprotein Complex
Neuropathic Pain-Signaling in Dorsal Horn Neurons
Sertoli-Sertoli Cell Junction Dynamics
Endothelin-1 Signaling Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NANOS1
Interactions:

    GeneGlobe Interaction Network for NANOS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NANOS1 (Q8WY413 ENSP000003932754) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
InteractantInteraction Details
GeneCardExternal ID(s)
PUM2Q8TB723, ENSP000003381734I2D: score=3 STRING: ENSP00000338173
GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
GRIN2DO153993, ENSP000002632694I2D: score=1 STRING: ENSP00000263269
DDX4ENSP000003470874STRING: ENSP00000347087
PUM1ENSP000003917234STRING: ENSP00000391723
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010631epithelial cell migration IDA17047063
GO:0016477cell migration IDA18223680
GO:0017148negative regulation of translation ISS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for NANOS1 available from Tocris Bioscience    About this table
CompoundAction CAS #
3-Bromo-7-nitroindazoleSelective nNOS inhibitor[74209-34-0]
Nomega-Propyl-L-arginine hydrochlorideHighly selective inhibitor of nNOS[137361-05-8]
ARL 17477 dihydrochlorideSelective nNOS inhibitor[180983-17-9]

1 Novoseek inferred chemical compound relationship for NANOS1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide 35.1 1 8972893 (1)



Find genes that share compounds with NANOS1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NANOS1 gene (2 alternative transcripts): 
NM_001009553.1  NM_199461.2  

Unigene Cluster for NANOS1:

Nanos homolog 1 (Drosophila)
Hs.591918  [show with all ESTs]
Unigene Representative Sequence: NM_199461
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340087 ENST00000425699(uc009xzf.1)
miRNA
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Block miRNA regulation of human, mouse, rat NANOS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NANOS1 (see all 60):
hsa-miR-549 hsa-miR-520f hsa-miR-136 hsa-miR-429 hsa-miR-4328 hsa-miR-106a hsa-miR-29a hsa-miR-4305
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat NANOS1
Clone
Products:
     
OriGene clones in human, mouse for NANOS1 (see all 8)
OriGene ORF clones in mouse, rat for NANOS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NANOS1 (NM_199461)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NANOS1
OriGene qSTAR qPCR primer pairs in human, mouse for NANOS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANOS1
  QuantiTect SYBR Green Assays in human, mouse, rat NANOS1
  QuantiFast Probe-based Assays in human, mouse, rat NANOS1

Additional mRNA sequence: 

AF086393.1 AF275269.2 AF458985.1 

4 DOTS entries:

DT.419410  DT.100798858  DT.40302531  DT.92421843 

Selected AceView cDNA sequences (see all 66):

AI090689 AI421274 AW340709 BE467063 AI572316 AI371014 AI138906 AI273269 
AW134982 AI422817 AW026179 BX094286 W79223 AW137865 N30160 BE218421 
W07677 AI240204 AI694996 BE503548 BE467767 BE327781 AA989054 BE467534 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NANOS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NANOS1 Expression
About this image


NANOS1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Endothelium (Cardiovascular System)
         Adult Endothelial Cells Blood Brain Barrier
 
 Neural Tube (Nervous System)
         Diencephalon
 
 Brain (Nervous System)
         Adult Endothelial Cells Blood Brain Barrier
 
 Heart (Cardiovascular System)
NANOS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NANOS1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591918

UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
Tissue specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed
during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the
germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells.
Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it
may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell
lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression
correlates with tumor aggressiveness

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NANOS1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nanos11 , 5 nanos homolog 1 (Drosophila)1, 5 84.6(n)1
84.09(a)1
  19 (56.52 cM)5
3323971  NM_178421.31  NP_848508.21 
 607559875 
chicken
(Gallus gallus)
Aves NANOS11 nanos homolog 1 (Drosophila) 71.49(n)
60.96(a)
  100857342  XM_003641500.1  XP_003641548.1 
lizard
(Anolis carolinensis)
Reptilia NANOS16
nanos homolog 1 (Drosophila)
78(a)
1 ↔ 1
GL343399.1(415396-415641)
African clawed frog
(Xenopus laevis)
Amphibia Xcat-22 X.laevis Xcat-2 mRNA 77.36(n)    X72340.1 
zebrafish
(Danio rerio)
Actinopterygii nanos16
nanos homolog 1
27(a)
1 ↔ 1
14(5129615-5130301) ENSDARG00000078976
fruit fly
(Drosophila melanogaster)
Insecta nos6
nanos
13(a)
1 → many
3R(14982962-14985924)


ENSEMBL Gene Tree for NANOS1 (if available)
TreeFam Gene Tree for NANOS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NANOS1 gene
NANOS22  NANOS32  
2 SIMAP similar genes for NANOS1 using alignment to 2 protein entries:     NANO1_HUMAN (see all proteins):
NANOS3    NANOS2

Find genes that share paralogs with NANOS1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NANOS1 (see all 131)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs127616831,2
C,F--120787316(+) CTGCTG/AGGCAC 1 -- us2k14Minor allele frequency- A:0.38NA 8
rs1479391411,2
--120787370(+) TGTTT-/CCCCACA 1 -- us2k10--------
rs2016179511,2
C--120787370(+) TTGTTC/TCNNNN 1 -- us2k10--------
rs1179152621,2
F--120787393(+) TCCAGA/GGTGAG 1 -- us2k11Minor allele frequency- G:0.01EA 120
rs1174796721,2
C,F--120787727(+) ATCGCT/CTGAGG 1 -- us2k11Minor allele frequency- C:0.10EA 120
rs677508431,2
C--120787793(-) TTTTC-/TT    
   TTTTT
TTTTT
1 -- us2k12Minor allele frequency- TTTTTTT:0.25NA 4
rs1835993211,2
--120787815(+) AGAAGA/GAAAAA 1 -- us2k10--------
rs1384100971,2
--120787912(+) GCGAGA/GTCTGG 1 -- us2k10--------
rs1884574021,2
--120787962(+) TCTACC/TAAAAT 1 -- us2k10--------
rs1818892551,2
--120788110(+) AGGAAA/GGAAGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for NANOS1 (120789228 - 120793854 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for NANOS1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv825582CNV Gain20364138

Human Gene Mutation Database (HGMD): NANOS1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NANOS1
DNA2.0 Custom Variant and Variant Library Synthesis for NANOS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608226   
OMIM disorders: 615413  
UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
  • Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis
    defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects.
    Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12
    patients. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 2 diseases for NANOS1:    
    About MalaCards
    spermatogenic failure 12    atherosclerosis

    1 disease from the University of Copenhagen DISEASES database for NANOS1:
    Azoospermia

    Find genes that share disorders with NANOS1           About GenesLikeMe


    Export disorders for NANOS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NANOS1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with NANOS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PubMed id 12690449)1, 2, 3, 9 Jaruzelska J....Reijo Pera R.A. (Dev. Genes Evol. 2003)
    2. Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo- astheno-teratozoospermia. (PubMed id 23315541)1, 2 Kusz-Zamelczyk K.... Jaruzelska J. (J. Med. Genet. 2013)
    3. NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells. (PubMed id 21800163)1, 2 Ginter-Matuszewska B....Jaruzelska J. (Histochem. Cell Biol. 2011)
    4. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PubMed id 19168546)1, 2 Ginter-Matuszewska B.... Jaruzelska J. (Mol. Hum. Reprod. 2009)
    5. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PubMed id 18223680)1, 2 Bonnomet A.... Nawrocki-Raby B. (Oncogene 2008)
    6. E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. (PubMed id 17047063)1, 2 Strumane K....van Roy F. (Cancer Res. 2006)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. (PubMed id 23320086)1 Lu C....Wang X. (PLoS ONE 2013)
    9. NANOS3 function in human germ cell development. (PubMed id 21421998)2 Julaton V.T. and Reijo Pera R.A. (Hum. Mol. Genet. 2011)
    10. Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes. (PubMed id 16573738)1 Kurokawa H....Tanaka M. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340719 HGNC: 23044 AceView: NANOS1 Ensembl:ENSG00000188613 euGenes: HUgn340719
    ECgene: NANOS1 H-InvDB: NANOS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NANOS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NANOS1 gene:
    Search GeneIP for patents involving NANOS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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