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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NANOS1 Gene

protein-coding   GIFtS: 50
GCID: GC10P120779

Nanos Homolog 1 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nanos Homolog 1 (Drosophila)1 2
NOS12 3 5
EC_Rep1a2 3
NOS-12 3
SPGF122
Nanos Homolog 12

External Ids:    HGNC: 230441   Entrez Gene: 3407192   Ensembl: ENSG000001886137   OMIM: 6082265   UniProtKB: Q8WY413   

Export aliases for NANOS1 gene to outside databases

Previous GC identifers: GC10U900443 GC10P120453 GC10P114419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NANOS1 Gene: 
NANOS1 (nanos homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with NANOS1 include rabies, and atherosclerosis. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex
with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and
anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion

summary for NANOS1 Gene:
Neuronal nitric oxide synthase (nNOS), along with inducible nitric oxide synthase (iNOS) and endothelial
nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and
molecular oxygen. It is activated at concentrations of calcium greater than 100 nM and requires co-factors
of tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity.
Transcriptional regulation of nNOS is very complex and the nNOS gene produces multiple mRNA transcripts
using alternate promoters, alternative splicing, cassette insertions/deletions, and varied sites for 3'-UTR
cleavage and polyadenylation. Some of these alterations lead to variation in amino acid sequence,
translating into nNOS isoforms with altered structural and functional properties. nNOS has been implicated
in a wide variety of physiological and pathological processes, including neurotransmission, neurotoxicity,
skeletal muscle contraction, sexual function, body fluid homeostasis and atherosclerosis. Consistent with
such wide involvement, nNOS is expressed in numerous tissues. The human gene encoding nNOS is localized to
chromosome 12q14.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NANOS1 gene promoter:
         TBP   Tal-1   C/EBPalpha   E47   Egr-2   HEN1   Pax-3   GATA-6   TFIID   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANOS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NANOS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.13

NANOS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOS1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P120779:  view genomic region     (about GC identifiers)

Start:
120,789,228 bp from pter      End:
120,793,854 bp from pter
Size:
4,627 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41 (See protein sequence)
Recommended Name: Nanos homolog 1  
Size: 292 amino acids; 30230 Da
Subunit: Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1
Subcellular location: Cytoplasm, perinuclear region. Cytoplasm. Note=Co-localizes with SNAPIN and PUM2 in the
perinuclear region of germ cells
Developmental stage: Fetal ovary and fetal testis (at protein level)

Explore the universe of human proteins at neXtProt for NANOS1: NX_Q8WY41

Explore proteomics data for NANOS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WY41

  • NANOS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NANOS1 Protein Expression
    REFSEQ proteins: NP_955631.1  
    ENSEMBL proteins: 
     ENSP00000345924   ENSP00000393275  

    Human Recombinant Protein Products for NANOS1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for NANOS1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NANOS1
    GenScript Custom Purified and Recombinant Proteins Services for NANOS1
    Novus Biologicals NANOS1 Proteins
    Novus Biologicals NANOS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NANOS1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12690449
    GO:0048471perinuclear region of cytoplasm IDA17047063

    NANOS1 for ontologies           About GeneDecksing



    NANOS1 Antibody Products: 
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    Abcam antibodies for NANOS1
    Cloud-Clone Corp. Antibodies for NANOS1 
    ThermoFisher Antibodies for NANOS1
    LSBio Antibodies in human, mouse, rat for NANOS1 

    Assay Products for NANOS1: 
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    GenScript Custom Assay Services for NANOS1
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    Cloud-Clone Corp. ELISAs for NANOS1 
    Cloud-Clone Corp. CLIAs for NANOS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024161 Znf_nanos-typ
     IPR008705 Nanos/Xcar2

    Graphical View of Domain Structure for InterPro Entry Q8WY41

    ProtoNet protein and cluster: Q8WY41

    1 Blocks protein domain: IPB008705 Nanos RNA-binding

    UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
    Domain: The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is
    essential for the translation repression activity of the protein (By similarity)
    Domain: The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction
    with SNAPIN
    Similarity: Belongs to the nanos family
    Similarity: Contains 1 nanos-type zinc finger


    NANOS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NANO1_HUMAN, Q8WY41
    Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex
    with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and
    anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion
    Induction: Down-regulated by E-cadherin

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI17047063
    GO:0008270zinc ion binding IEA--
    GO:0030371translation repressor activity ISS--
         
    NANOS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nanos1):
     normal 

    NANOS1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NANOS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NANOS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NANOS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NANOS1 

    miRNA
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate NANOS1 (see all 60):
    hsa-miR-549 hsa-miR-520f hsa-miR-136 hsa-miR-429 hsa-miR-4328 hsa-miR-106a hsa-miR-29a hsa-miR-4305
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NANOS1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for NANOS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANOS1 (NM_199461)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS1
    Sirion Biotech Customized lentivirus for stable overexpression of NANOS1 
                         Customized lentivirus expression plasmids for stable overexpression of NANOS1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NANOS1
    Search LifeMap BioReagents cell lines for NANOS1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NANOS1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for NANOS1 (Q8WY413 ENSP000003932754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUM2Q8TB723, ENSP000003381734I2D: score=3 STRING: ENSP00000338173
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    GRIN2DO153993, ENSP000002632694I2D: score=1 STRING: ENSP00000263269
    PUM1ENSP000003917234STRING: ENSP00000391723
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010631epithelial cell migration IDA17047063
    GO:0016477cell migration IDA18223680
    GO:0017148negative regulation of translation ISS--

    NANOS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NANOS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NANOS1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    3-Bromo-7-nitroindazoleSelective nNOS inhibitor[74209-34-0]
    Nomega-Propyl-L-arginine hydrochlorideHighly selective inhibitor of nNOS[137361-05-8]
    ARL 17477 dihydrochlorideSelective nNOS inhibitor[180983-17-9]

    1 Novoseek inferred chemical compound relationship for NANOS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 35.1 1 8972893 (1)

    Search CenterWatch for drugs/clinical trials and news about NANOS1 / NANO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NANOS1 gene (2 alternative transcripts): 
    NM_001009553.1  NM_199461.2  

    Unigene Cluster for NANOS1:

    Nanos homolog 1 (Drosophila)
    Hs.591918  [show with all ESTs]
    Unigene Representative Sequence: NM_199461
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340087 ENST00000425699(uc009xzf.1)
    miRNA
    Products:
         
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate NANOS1 (see all 60):
    hsa-miR-549 hsa-miR-520f hsa-miR-136 hsa-miR-429 hsa-miR-4328 hsa-miR-106a hsa-miR-29a hsa-miR-4305
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NANOS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOS1
    Clone
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    OriGene clones in human, mouse for NANOS1 (see all 8)
    OriGene ORF clones in mouse, rat for NANOS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANOS1 (NM_199461)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOS1
    Sirion Biotech Customized lentivirus for stable overexpression of NANOS1 
                         Customized lentivirus expression plasmids for stable overexpression of NANOS1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NANOS1
    OriGene qSTAR qPCR primer pairs in human, mouse for NANOS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NANOS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOS1

    Additional mRNA sequence: 

    AF086393.1 AF275269.2 AF458985.1 

    4 DOTS entries:

    DT.419410  DT.100798858  DT.40302531  DT.92421843 

    24/66 AceView cDNA sequences (see all 66):

    AW026179 AW340709 AI138906 AI422817 AI572316 AI371014 BX094286 W79223 
    AI421274 BE467063 AW134982 AI273269 AI090689 AI797130 NM_199461 AI694996 
    BE467534 BE467767 AI240204 H27794 AI206395 BE327781 AI188525 BE503548 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NANOS1 expression in normal human tissues (normalized intensities)      NANOS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NANOS1 Expression
    About this image


    NANOS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             brain/hindbrain   
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Heart (Cardiovascular System)

    See NANOS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NANOS1

    SOURCE GeneReport for Unigene cluster: Hs.591918

    UniProtKB/Swiss-Prot: NANO1_HUMAN, Q8WY41
    Tissue specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed
    during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the
    germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells.
    Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it
    may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell
    lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression
    correlates with tumor aggressiveness

        SABiosciences Custom PCR Arrays for NANOS1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NANOS1 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nanos11 , 5 nanos homolog 1 (Drosophila)1, 5 85.91(n)1
    85.28(a)1
      19 (56.52 cM)5
    3323971  NM_178421.31  NP_848508.21 
     607559875 
    chicken
    (Gallus gallus)
    Aves LOC1008573421 nanos homolog 1-like 70.31(n)
    58.7(a)
      100857342  XM_003641500.1  XP_003641548.1 
    lizard
    (Anolis carolinensis)
    Reptilia NANOS16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343399.1(415396-415641)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xcat-22 X.laevis Xcat-2 mRNA 77.36(n)    X72340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NANOS16
    nanos homolog 1 (Drosophila)
    36(a)
    1 ↔ 1
    14(5129615-5130301)
    fruit fly
    (Drosophila melanogaster)
    Insecta nos6
    nanos
    12(a)
    1 → many
    3R(14982962-14985924)


    ENSEMBL Gene Tree for NANOS1 (if available)
    TreeFam Gene Tree for NANOS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NANOS1 gene
    NANOS22  NANOS32  
    2 SIMAP similar genes for NANOS1 using alignment to 2 protein entries:     NANO1_HUMAN (see all proteins):
    NANOS3    NANOS2

    NANOS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/128 SNPs in NANOS1 are shown (see all 128)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127616831,2
    C,F--120787316(+) CTGCTG/AGGCAC 1 -- us2k14Minor allele frequency- A:0.38NA 8
    rs1479391411,2
    --120787370(+) TGTTT-/CCCCACA 1 -- us2k10--------
    rs2016179511,2
    C--120787370(+) TTGTTC/TCNNNN 1 -- us2k10--------
    rs1179152621,2
    F--120787393(+) TCCAGA/GGTGAG 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1174796721,2
    C,F--120787727(+) ATCGCT/CTGAGG 1 -- us2k11Minor allele frequency- C:0.10EA 120
    rs677508431,2
    C--120787793(-) TTTTC-/TT    
       TTTTT
    TTTTT
    1 -- us2k12Minor allele frequency- TTTTTTT:0.25NA 4
    rs1835993211,2
    --120787815(+) AGAAGA/GAAAAA 1 -- us2k10--------
    rs1384100971,2
    --120787912(+) GCGAGA/GTCTGG 1 -- us2k10--------
    rs1884574021,2
    --120787962(+) TCTACC/TAAAAT 1 -- us2k10--------
    rs1818892551,2
    --120788110(+) AGGAAA/GGAAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NANOS1 (120789228 - 120793854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NANOS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv825582CNV Gain20364138


    Human Gene Mutation Database (HGMD): NANOS1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608226    OMIM disorders: --

    6 diseases for NANOS1:    About MalaCards
    rabies    atherosclerosis    azoospermia    endotheliitis
    infertility    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NANOS1:
    Azoospermia

    NANOS1 for disorders           About GeneDecksing


    Export disorders for NANOS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NANOS1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with NANOS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PubMed id 12690449)1, 2, 3, 9 Jaruzelska J....Reijo Pera R.A. (2003)
    2. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PubMed id 19168546)1, 2 Ginter-Matuszewska B....Jaruzelska J. (2009)
    3. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PubMed id 18223680)1, 2 Bonnomet A....Nawrocki-Raby B. (2008)
    4. E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. (PubMed id 17047063)1, 2 Strumane K....van Roy F. (2006)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. (PubMed id 23320086)1 Lu C....Wang X. (2013)
    7. NANOS3 function in human germ cell development. (PubMed id 21421998)2 Julaton V.T. and Reijo Pera R.A. (2011)
    8. NANOS1 and PUMILIO2 bind microRNA biogenesis factor GE MIN3, within chromatoid body in human germ cells. (PubMed id 21800163)1 Ginter-Matuszewska B....Jaruzelska J. (2011)
    9. Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes. (PubMed id 16573738)1 Kurokawa H....Tanaka M. (2006)
    10. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. (PubMed id 10862698)1 Husi H....Grant S.G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340719 HGNC: 23044 AceView: NANOS1 Ensembl:ENSG00000188613 euGenes: HUgn340719
    ECgene: NANOS1 H-InvDB: NANOS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NANOS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NANOS1 gene:
    Search GeneIP for patents involving NANOS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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