Aliases for NANOGP8 Gene
External Ids for NANOGP8 Gene
Previous GeneCards Identifiers for NANOGP8 Gene
This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009]
GeneCards Summary for NANOGP8 Gene
NANOGP8 (Nanog Homeobox Pseudogene 8) is a Pseudogene. Diseases associated with NANOGP8 include breast adenocarcinoma. Among its related pathways are Proteoglycans in cancer and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.
UniProtKB/Swiss-Prot for NANOGP8 Gene
May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.