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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NANOGP8 Gene

pseudogene   GIFtS: 24
GCID: GC15M035375

Nanog Homeobox Pseudogene 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nanog Homeobox Pseudogene 81 2
NANOG2
NANOGP12
PN82

External Ids:    HGNC: 231061   Entrez Gene: 3881122   Ensembl: ENSG000002551927   UniProtKB: Q6NSW73   

Export aliases for NANOGP8 gene to outside databases

Previous GC identifers: GC15M032954 GC15U900257 GC15M033091 GC15M033162 GC15M012220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NANOGP8 Gene:
This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating
self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame
that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from
this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies
using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell
proliferation, similar to NANOG. (provided by RefSeq, Sep 2009)

GeneCards Summary for NANOGP8 Gene: 
NANOGP8 (Nanog homeobox pseudogene 8) is a pseudogene. Diseases associated with NANOGP8 include breast adenocarcinoma, and osteosarcoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Function: May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S
phase and cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NANOGP8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANOGP8 promoter sequence
   Search SABiosciences Chromatin IP Primers for NANOGP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOGP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q13.3

NANOGP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOGP8 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M035375:  view genomic region     (about GC identifiers)

Start:
35,375,427 bp from pter      End:
35,377,509 bp from pter
Size:
2,083 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7 (See protein sequence)
Recommended Name: Putative homeobox protein NANOGP8  
Size: 305 amino acids; 34615 Da
Subcellular location: Nucleus
Miscellaneous: Almost identical to NANOG. There is only one change in the inferred amino acid sequence from
'Gln-253' in NANOG to His-253 in NANOGP8
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NANOGP8: NX_Q6NSW7

NANOGP8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

NANOGP8 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
NKL: Homeoboxes / ANTP class : NKL subclass

3 InterPro protein domains:
 IPR017970 Homeobox_CS
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q6NSW7

ProtoNet protein and cluster: Q6NSW7

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Similarity: Belongs to the Nanog homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


NANOGP8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NANP8_HUMAN, Q6NSW7
Function: May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S
phase and cell proliferation

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
NANOGP8 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NANOGP8

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--

NANOGP8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000528386 ENST00000455486
miRNA
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12 AceView cDNA sequences:

BC069807 AU125832 BX956457 BF773084 BF773088 AI656990 AA227154 AA252276 
AA301076 AW275006 AU148881 AA301077 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NANOGP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NANOGP8 Expression
About this image

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Tissue specificity: Expressed in osteosarcoma cancer cell line (at protein level), breast and urinary bladder
tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for NANOGP8 (if available)
TreeFam Gene Tree for NANOGP8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NANOGP8 gene
10 SIMAP similar genes for NANOGP8 using alignment to 23 protein entries:     NANP8_HUMAN (see all proteins):
NANOG    NANOGP1    NKX2-5    MSX1    PITX2    HOXB1
HOXA4    POU6F1    MNX1    DLX6

NANOGP8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing NANOGP8
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
4 diseases for NANOGP8:    About MalaCards
breast adenocarcinoma    osteosarcoma    adenocarcinoma    colon cancer


NANOGP8 for disorders           About GeneDecksing

Genetic Association Database (GAD): NANOGP8

Export disorders for NANOGP8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NANOGP8 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NANOGP8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. NANOGP8 is a retrogene expressed in cancers. (PubMed id 16623708)1, 2 Zhang J.... Dai J. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Eleven daughters of NANOG. (PubMed id 15233988)1, 2 Booth H.A. and Holland P.W. (2004)
  4. Functional evidence that the self-renewal gene NANOG regulates human tumor development. (PubMed id 19415763)1, 9 Jeter C.R....Tang D.G. (2009)
  5. Evolution of the NANOG pseudogene family in the human and chimpanzee genomes. (PubMed id 16469101)2, 9 Fairbanks D.J. and Maughan P.J. (2006)
  6. NANOGP8: evolution of a human-specific retro-oncogene. (PubMed id 23173096)1 Fairbanks D.J....Maughan P.J. (2012)
  7. Differential expression of nanog1 and nanogp8 in colon cancer cells. (PubMed id 22079639)1 Ishiguro T....Okamoto K. (2012)
  8. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. (PubMed id 20581802)1 Zbinden M....Ruiz i Altaba A. (2010)
  9. Expression of NANOG and NANOGP8 in a variety of undif ferentiated and differentiated human cells. (PubMed id 21136380)1 Ambady S....Dominko T. (2010)
  10. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388112 HGNC: 23106 AceView: NANOGP8 Ensembl:ENSG00000255192 euGenes: HUgn388112
ECgene: NANOGP8 H-InvDB: NANOGP8

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NANOGP8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NANOGP8 gene:
Search GeneIP for patents involving NANOGP8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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