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Aliases for NANOGP8 Gene

Aliases for NANOGP8 Gene

  • Nanog Homeobox Pseudogene 8 2 3
  • NANOG Pseudogene-1 3
  • NANOGP1 3
  • NANOG 3
  • PN8 3

External Ids for NANOGP8 Gene

Previous GeneCards Identifiers for NANOGP8 Gene

  • GC15M032954
  • GC15U900257
  • GC15M033091
  • GC15M033162
  • GC15M035375
  • GC15M012220

Summaries for NANOGP8 Gene

Entrez Gene Summary for NANOGP8 Gene

  • This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009]

GeneCards Summary for NANOGP8 Gene

NANOGP8 (Nanog Homeobox Pseudogene 8) is a Pseudogene. Among its related pathways are Developmental Biology and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for NANOGP8 Gene

  • May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOGP8 Gene

Genomics for NANOGP8 Gene

Genomic Location for NANOGP8 Gene

Chromosome:
15
Start:
35,083,226 bp from pter
End:
35,085,308 bp from pter
Size:
2,083 bases
Orientation:
Minus strand

Genomic View for NANOGP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NANOGP8 Gene

No data available for Regulatory Elements for NANOGP8 Gene

Proteins for NANOGP8 Gene

  • Protein details for NANOGP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSW7-NANP8_HUMAN
    Recommended name:
    Putative homeobox protein NANOGP8
    Protein Accession:
    Q6NSW7

    Protein attributes for NANOGP8 Gene

    Size:
    305 amino acids
    Molecular mass:
    34615 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Almost identical to NANOG. There is only one change in the inferred amino acid sequence from Gln-253 in NANOG to His-253 in NANOGP8

    Three dimensional structures from OCA and Proteopedia for NANOGP8 Gene

neXtProt entry for NANOGP8 Gene

Proteomics data for NANOGP8 Gene at MOPED

Post-translational modifications for NANOGP8 Gene

No Post-translational modifications

Other Protein References for NANOGP8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for NANOGP8 Gene

Domains & Families for NANOGP8 Gene

Gene Families for NANOGP8 Gene

Protein Domains for NANOGP8 Gene

Suggested Antigen Peptide Sequences for NANOGP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NSW7

UniProtKB/Swiss-Prot:

NANP8_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Nanog homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Nanog homeobox family.
genes like me logo Genes that share domains with NANOGP8: view

Function for NANOGP8 Gene

Molecular function for NANOGP8 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.

Gene Ontology (GO) - Molecular Function for NANOGP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NANOGP8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NANOGP8 Gene

Localization for NANOGP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOGP8 Gene

Gene Ontology (GO) - Cellular Components for NANOGP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NANOGP8: view

No data available for Subcellular locations from COMPARTMENTS for NANOGP8 Gene

Pathways & Interactions for NANOGP8 Gene

genes like me logo Genes that share pathways with NANOGP8: view

Interacting Proteins for NANOGP8 Gene

Gene Ontology (GO) - Biological Process for NANOGP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NANOGP8: view

No data available for SIGNOR curated interactions for NANOGP8 Gene

Drugs & Compounds for NANOGP8 Gene

No Compound Related Data Available

Transcripts for NANOGP8 Gene

mRNA/cDNA for NANOGP8 Gene

(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NANOGP8 Gene

No ASD Table

Relevant External Links for NANOGP8 Gene

GeneLoc Exon Structure for
NANOGP8
ECgene alternative splicing isoforms for
NANOGP8

Expression for NANOGP8 Gene

mRNA expression in normal human tissues for NANOGP8 Gene

mRNA differential expression in normal tissues according to GTEx for NANOGP8 Gene

This gene is overexpressed in Testis (x5.3).

mRNA Expression by UniProt/SwissProt for NANOGP8 Gene

Q6NSW7-NANP8_HUMAN
Tissue specificity: Expressed in osteosarcoma cancer cell line (at protein level), breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines.
genes like me logo Genes that share expression patterns with NANOGP8: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NANOGP8 Gene

Orthologs for NANOGP8 Gene

Evolution for NANOGP8 Gene

ENSEMBL:
Gene Tree for NANOGP8 (if available)
TreeFam:
Gene Tree for NANOGP8 (if available)

No data available for Orthologs for NANOGP8 Gene

Paralogs for NANOGP8 Gene

genes like me logo Genes that share paralogs with NANOGP8: view

No data available for Paralogs for NANOGP8 Gene

Variants for NANOGP8 Gene

Relevant External Links for NANOGP8 Gene

HapMap Linkage Disequilibrium report
NANOGP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NANOGP8 Gene

Disorders for NANOGP8 Gene

Relevant External Links for NANOGP8

Genetic Association Database (GAD)
NANOGP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOGP8
genes like me logo Genes that share disorders with NANOGP8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NANOGP8 Gene

Publications for NANOGP8 Gene

  1. Functional evidence that the self-renewal gene NANOG regulates human tumor development. (PMID: 19415763) Jeter C.R. … Tang D.G. (Stem Cells 2009) 23 67
  2. Evolution of the NANOG pseudogene family in the human and chimpanzee genomes. (PMID: 16469101) Fairbanks D.J. … Maughan P.J. (BMC Evol. Biol. 2006) 23 67
  3. Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species. (PMID: 24598770) Liu B. … Tang D.G. (PLoS ONE 2014) 67
  4. Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer. (PMID: 23752184) Palla A.R. … Serrano M. (Oncogene 2014) 67
  5. In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals. (PMID: 23839044) Badeaux M.A. … Tang D.G. (Cell Cycle 2013) 67

Products for NANOGP8 Gene

Sources for NANOGP8 Gene

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