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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NANOGP8 Gene

pseudogene   GIFtS: 26
GCID: GC15M035375

Nanog homeobox pseudogene 8
 Explore 3 diseases affiliated with
NANOGP8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NANOGP8    

Aliases
for NANOGP8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nanog Homeobox Pseudogene 81 2
NANOG2
NANOGP12
PN82

External Ids:    HGNC: 231061   Entrez Gene: 3881122   Ensembl: ENSG000002551927   UniProtKB: Q6NSW73   

Export aliases for NANOGP8 gene to outside databases

Previous GC identifers: GC15M032954 GC15U900257 GC15M033091 GC15M033162 GC15M012220


Summaries
for NANOGP8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NANOGP8:
This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating
self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that
could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this
pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a
recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation,
similar to NANOG. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Function: May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S
phase and cell proliferation




Genomic Views
for NANOGP8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NANOGP8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NANOGP8 promoter sequence
   Search SABiosciences Chromatin IP Primers for NANOGP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOGP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q13.3

NANOGP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOGP8 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M035375:  view genomic region     (about GC identifiers)

Start:
 35,375,427 bp from pter      End:
 35,377,509 bp from pter
Size:
 2,083 bases      Orientation:
 minus strand

Proteins
for NANOGP8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7 (See protein sequence)
Recommended Name: Putative homeobox protein NANOGP8  
Size: 305 amino acids; 34615 Da
Subcellular location: Nucleus
Miscellaneous: Almost identical to NANOG. There is only one change in the inferred amino acid sequence from 'Gln-253'
in NANOG to His-253 in NANOGP8
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NANOGP8: NX_Q6NSW7

NANOGP8 Protein expression data from MOPED and PaxDb: --

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Uscn Proteins for NANOGP8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--


NANOGP8 for ontologies           About GeneDecksing



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Protein Domains /
Families
for NANOGP8 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
NANOGP8 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR017970 Homeobox_CS
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q6NSW7

ProtoNet protein and cluster: Q6NSW7

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Similarity: Belongs to the Nanog homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Function
for NANOGP8 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Function: May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S
phase and cell proliferation

miRNA
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Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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LifeMap BioReagents: cell lines associated with NANOGP8: Human Embryonic Stem Cell Line ESI-017,
Human Embryonic Stem Cell Line ESI-035, Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
Human Embryonic Stem Cell Line ESI-053

In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--


NANOGP8 for ontologies           About GeneDecksing



Pathways & Interactions
for NANOGP8 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NANOGP8

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--


NANOGP8 for ontologies           About GeneDecksing



Drugs & Compounds
for NANOGP8 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for NANOGP8
Search CenterWatch for drugs/clinical trials and news about NANOGP8 

Transcripts
for NANOGP8 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000528386 ENST00000455486

miRNA
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Inhib. RNA
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Clone
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Primer
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12 AceView cDNA sequences:

BX956457 BC069807 AU125832 BF773088 BF773084 AI656990 AA227154 AU148881 
AA252276 AA301077 AW275006 AA301076 

GeneLoc Exon Structure


Expression
for NANOGP8 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NANOGP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

NANOGP8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

UniProtKB/Swiss-Prot: NANP8_HUMAN, Q6NSW7
Tissue specificity: Expressed in osteosarcoma cancer cell line (at protein level), breast and urinary bladder tissues,
and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines

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Primer
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In Situ
Assay Products: 
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Orthologs
for NANOGP8 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for NANOGP8 (if available)
TreeFam Gene Tree for NANOGP8 (if available) 

Paralogs
for NANOGP8 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for NANOGP8 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NANOGP8
DNA2.0 Custom Variant and Variant Library Synthesis for NANOGP8

Disorders / Diseases
for NANOGP8 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
NANOGP8 for disorders           About GeneDecksing

3 diseases for NANOGP8:    About MalaCards
breast adenocarcinoma    osteosarcoma    adenocarcinoma


Export disorders for NANOGP8 gene to outside databases

Publications
for NANOGP8 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NANOGP8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NANOGP8)		    Utopia: connect your pdf to the dynamic
world of online information

  1. NANOGP8 is a retrogene expressed in cancers. (PubMed id 16623708)1, 2 Zhang J.... Dai J. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Eleven daughters of NANOG. (PubMed id 15233988)1, 2 Booth H.A. and Holland P.W. (2004)
  4. Functional evidence that the self-renewal gene NANOG regulates human tumor development. (PubMed id 19415763)1, 9 Jeter C.R....Tang D.G. (2009)
  5. Evolution of the NANOG pseudogene family in the human and chimpanzee genomes. (PubMed id 16469101)2, 9 Fairbanks D.J. and Maughan P.J. (2006)
  6. Differential expression of nanog1 and nanogp8 in colon cancer cells. (PubMed id 22079639)1 Ishiguro T....Okamoto K. (2012)
  7. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. (PubMed id 20581802)1 Zbinden M....Ruiz i Altaba A. (2010)
  8. Expression of NANOG and NANOGP8 in a variety of undif ferentiated and differentiated human cells. (PubMed id 21136380)1 Ambady S....Dominko T. (2010)
  9. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PubMed id 15108323)1 Hart A.H.... Robb L. (2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for NANOGP8 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing NANOGP8 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388112 HGNC: 23106 AceView: NANOGP8 Ensembl:ENSG00000255192 euGenes: HUgn388112
ECgene: NANOGP8 H-InvDB: NANOGP8

Other Databases showing NANOGP8 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing NANOGP8 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NANOGP8 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for NANOGP8 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NANOGP8 gene:
Search GeneIP for patents involving NANOGP8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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 NANOGP8 Proteins, Antibodies, CLIAs, and ELISAs
 Cell Lines associated with NANOGP8: Human Embryonic Stem Cell Line ESI-017,
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