NANOGP1 Gene
pseudogene GIFtS: 19
GCID: GC12P008028
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Nanog homeobox pseudogene 1
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Aliases
for NANOGP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nanog Homeobox Pseudogene 11 2 | | NANOG21 2 3 |
Export aliases for NANOGP1 gene to outside databasesPrevious GC identifers: GC12U900442 GC12P007917 |
Summaries
for NANOGP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NANG2_HUMAN, Q8N7R0Function: Probable transcriptional regulator
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Genomic Views
for NANOGP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NANOGP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NANOGP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOGP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31NANOGP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P008028: view genomic region
(about GC identifiers)
Start:
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8,025,534 bp from pter |
End:
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8,052,674 bp from pter |
Size:
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27,141 bases |
Orientation:
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plus strand |
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Proteins
for NANOGP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: NANG2_HUMAN, Q8N7R0 (See
protein sequence)Recommended Name: Putative homeobox protein NANOG2 Size: 232 amino acids; 26880 Da
Subcellular location: Nucleus (By similarity)
Developmental stage: Expressed in embryonic stem cells (ES)
Caution: Could be the product of a pseudogene. According to PubMed:15233988
Caution: Exists an other tandem duplicated gene (NANOG) and 10 other NANOG-related nucleotide sequences located ondifferent chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8which is a retrogeneExplore the universe of human proteins at neXtProt for NANOGP1: NX_Q8N7R0
NANOGP1 Protein expression data from MOPED and PaxDb: --
ENSEMBL proteins: ENSP00000432545 ENSP00000435164 ENSP00000437055
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
NANOGP1 for ontologies About GeneDecksing
NANOGP1 Antibody Products:
Assay Products for NANOGP1: |
Protein
Domains /
Families
for NANOGP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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NANOGP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7R0ProtoNet protein and cluster: Q8N7R0 UniProtKB/Swiss-Prot: NANG2_HUMAN, Q8N7R0Similarity: Belongs to the Nanog homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for NANOGP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: NANG2_HUMAN, Q8N7R0Function: Probable transcriptional regulator
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
NANOGP1 for ontologies About GeneDecksing
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Pathways & Interactions
for NANOGP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NANOGP1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
NANOGP1 for ontologies About GeneDecksing
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Drugs & Compounds
for NANOGP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NANOGP1
Search CenterWatch for drugs/clinical trials and news about NANOGP1 
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Transcripts
for NANOGP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530989(uc001qtp.1) ENST00000525030 ENST00000533269
GeneLoc Exon Structure
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Expression
for NANOGP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NANOGP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for NANOGP1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NANOGP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOGP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOGP1 |
Orthologs
for NANOGP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NANOGP1 gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
27(a) |
1 → many |
2(80930156-80934421) |
zebrafish
(Danio rerio) |
Actinopterygii |
nanog6 |
nanog homeobox |
14(a) |
1 → many |
24(12738148-12743225) |
Species with no ortholog for NANOGP1
ENSEMBL Gene Tree for NANOGP1 (if available)
TreeFam Gene Tree for NANOGP1 (if available) |
Paralogs
for NANOGP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NANOGP1 gene
- NANOG2
8 SIMAP similar genes for NANOGP1 using alignment to 4 protein entries: NANG2_HUMAN (see all proteins):NANOG NANOGP8 MSX1 NKX2-5 HOXA4 HOXB1
POU6F1 MNX1
NANOGP1 for paralogs About GeneDecksing
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Genomic Variants
for NANOGP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NANOGP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for NANOGP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for NANOGP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NANOGP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PubMed id 15108323)1, 2, 3 Hart A.H.... Robb L. (2004)
- Eleven daughters of NANOG. (PubMed id 15233988)1, 2, 3 Booth H.A. and Holland P.W. (2004)
- Evolution of the NANOG pseudogene family in the human and chimpanzee genomes. (PubMed id 16469101)1, 2 Fairbanks D.J. and Maughan P.J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Embryonic NANOG activity defines colorectal cancer ste m cells and modulates through AP1- and TCF-dependent mechanisms. (PubMed id 22851508)1 Ibrahim E.E....Nateri A.S. (2012)
- Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells. (PubMed id 20427424)1 Eberle I....Marschalek R. (2010)
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External Searches for NANOGP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NANOGP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing NANOGP1 gene
(According to HUGE)
About This Section
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Specialized Databases showing NANOGP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NANOGP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NANOGP1 gene:
Search GeneIP for patents involving NANOGP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NANOGP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NANOGP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NANOGP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOGP1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOGP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOGP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOGP1 |
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| | | | Search Tocris compounds for NANOGP1 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for NANOGP1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NANOGP1 |
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