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Aliases for NANOGNB Gene

Aliases for NANOGNB Gene

  • NANOG Neighbor Homeobox 2 3 5
  • Homeobox Protein C14 4
  • Homeobox C14 2

External Ids for NANOGNB Gene

Previous GeneCards Identifiers for NANOGNB Gene

  • GC12P007919

Summaries for NANOGNB Gene

GeneCards Summary for NANOGNB Gene

NANOGNB (NANOG Neighbor Homeobox) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo.

Additional gene information for NANOGNB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOGNB Gene

Genomics for NANOGNB Gene

Regulatory Elements for NANOGNB Gene

Enhancers for NANOGNB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006940 1.9 FANTOM5 ENCODE dbSUPER 14.6 -811.6 -811558 25 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF384 CHD4 ENSG00000219410 ENSG00000247853 SPSB2 NCAPD2 SCARNA12 ING4 ENSG00000256967 EMG1
GH12H006934 1.6 Ensembl ENCODE dbSUPER 14.6 -827.8 -827780 4 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ING4 CHD4 ZNF384 LOC100419825 LOC100420983 DPPA3 LOC100131676 NANOGNB RPS20P29 ENSG00000219410
GH12H006826 1.3 ENCODE dbSUPER 14.6 -936.5 -936519 3 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 MXD4 NFYC ZNF384 ENSG00000219410 CHD4 ENSG00000247853 P3H3 NCAPD2 ATN1 SPSB2 EMG1 SCARNA12
GH12H006967 1.1 ENCODE 14.6 -795.3 -795299 5 FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF384 EMG1 CHD4 ENSG00000247853 NOP2 LOC100419825 LOC100420983 LOC100131676 NANOGNB RPS20P29
GH12H007757 0.6 Ensembl ENCODE 0.4 -6.7 -6655 1 POU5F1 CLEC4C NANOGNB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NANOGNB on UCSC Golden Path with GeneCards custom track

Genomic Location for NANOGNB Gene

Chromosome:
12
Start:
7,765,216 bp from pter
End:
7,774,121 bp from pter
Size:
8,906 bases
Orientation:
Plus strand

Genomic View for NANOGNB Gene

Genes around NANOGNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOGNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOGNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOGNB Gene

Proteins for NANOGNB Gene

  • Protein details for NANOGNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5D8-NANGN_HUMAN
    Recommended name:
    NANOG neighbor homeobox
    Protein Accession:
    Q7Z5D8

    Protein attributes for NANOGNB Gene

    Size:
    188 amino acids
    Molecular mass:
    22750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NANOGNB Gene

Post-translational modifications for NANOGNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOGNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOGNB Gene

Domains & Families for NANOGNB Gene

Gene Families for NANOGNB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NANOGNB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOGNB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NANOGNB: view

No data available for UniProtKB/Swiss-Prot for NANOGNB Gene

Function for NANOGNB Gene

Phenotypes From GWAS Catalog for NANOGNB Gene

Gene Ontology (GO) - Molecular Function for NANOGNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NANOGNB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NANOGNB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NANOGNB Gene

Localization for NANOGNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOGNB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOGNB gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NANOGNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NANOGNB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NANOGNB Gene

Pathways & Interactions for NANOGNB Gene

SuperPathways for NANOGNB Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with NANOGNB: view

Pathways by source for NANOGNB Gene

1 BioSystems pathway for NANOGNB Gene

Interacting Proteins for NANOGNB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371553%0d%0a9606.ENSP00000244745%0d%0a
Selected Interacting proteins: Q7Z5D8-NANGN_HUMAN ENSP00000371553 for NANOGNB Gene via IID STRING

Gene Ontology (GO) - Biological Process for NANOGNB Gene

None

No data available for SIGNOR curated interactions for NANOGNB Gene

Drugs & Compounds for NANOGNB Gene

No Compound Related Data Available

Transcripts for NANOGNB Gene

mRNA/cDNA for NANOGNB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOGNB Gene

NANOG neighbor homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NANOGNB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NANOGNB Gene

No ASD Table

Relevant External Links for NANOGNB Gene

GeneLoc Exon Structure for
NANOGNB
ECgene alternative splicing isoforms for
NANOGNB

Expression for NANOGNB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NANOGNB Gene

mRNA differential expression in normal tissues according to GTEx for NANOGNB Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of NANOGNB Gene:

NANOGNB

SOURCE GeneReport for Unigene cluster for NANOGNB Gene:

Hs.558004
genes like me logo Genes that share expression patterns with NANOGNB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOGNB Gene

Orthologs for NANOGNB Gene

This gene was present in the common ancestor of mammals.

Orthologs for NANOGNB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOGNB 33 34
  • 98.76 (n)
dog
(Canis familiaris)
Mammalia NANOGNB 33 34
  • 74.49 (n)
Species where no ortholog for NANOGNB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOGNB Gene

ENSEMBL:
Gene Tree for NANOGNB (if available)
TreeFam:
Gene Tree for NANOGNB (if available)

Paralogs for NANOGNB Gene

Pseudogenes.org Pseudogenes for NANOGNB Gene

genes like me logo Genes that share paralogs with NANOGNB: view

No data available for Paralogs for NANOGNB Gene

Variants for NANOGNB Gene

Sequence variations from dbSNP and Humsavar for NANOGNB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000835827 -- 7,773,801(+) ACAGA(A/T)GGAGA reference, missense
rs1000971987 -- 7,768,059(+) AATCA(A/G)TATTT intron-variant
rs1001024289 -- 7,768,526(+) TTCTT(C/T)TTTTT intron-variant
rs1001194405 -- 7,766,074(+) CTTGA(C/G)GAAGC intron-variant
rs1001289355 -- 7,773,999(+) GTGGA(C/G)TAGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NANOGNB Gene

Variant ID Type Subtype PubMed ID
dgv57e55 CNV gain 17911159
dgv5e196 CNV duplication 17116639
dgv6e196 CNV duplication 17116639
esv2422393 CNV duplication 17116639
esv2759877 CNV gain+loss 17122850
esv3628440 CNV loss 21293372
esv3628441 CNV gain 21293372
esv3892131 CNV gain 25118596
nsv428270 CNV gain 18775914
nsv8897 CNV gain 18304495

Variation tolerance for NANOGNB Gene

Gene Damage Index Score: 2.10; 38.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOGNB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOGNB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOGNB Gene

Disorders for NANOGNB Gene

Relevant External Links for NANOGNB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOGNB

No disorders were found for NANOGNB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NANOGNB Gene

Publications for NANOGNB Gene

  1. The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages. (PMID: 21679462) Zhong YF … Holland PW (BMC evolutionary biology 2011) 2 3 60
  2. NANOG (PMID: 28446706) Dunwell TL … Holland PWH (Open biology 2017) 3 60
  3. Transcriptional regulatory network of SOX4 during myoblast differentiation. (PMID: 25969425) Jang SM … Choi KH (Biochemical and biophysical research communications 2015) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for NANOGNB Gene

Sources for NANOGNB Gene

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