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Aliases for NANOGNB Gene

Aliases for NANOGNB Gene

  • NANOG Neighbor Homeobox 2 3 5
  • Homeobox Protein C14 4
  • Homeobox C14 2

External Ids for NANOGNB Gene

Previous GeneCards Identifiers for NANOGNB Gene

  • GC12P007919

Summaries for NANOGNB Gene

GeneCards Summary for NANOGNB Gene

NANOGNB (NANOG Neighbor Homeobox) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOGNB Gene

Genomics for NANOGNB Gene

Genomic Location for NANOGNB Gene

Chromosome:
12
Start:
7,765,216 bp from pter
End:
7,774,121 bp from pter
Size:
8,906 bases
Orientation:
Plus strand

Genomic View for NANOGNB Gene

Genes around NANOGNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOGNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOGNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOGNB Gene

No data available for Regulatory Elements for NANOGNB Gene

Proteins for NANOGNB Gene

  • Protein details for NANOGNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5D8-NANGN_HUMAN
    Recommended name:
    NANOG neighbor homeobox
    Protein Accession:
    Q7Z5D8

    Protein attributes for NANOGNB Gene

    Size:
    188 amino acids
    Molecular mass:
    22750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NANOGNB Gene

Proteomics data for NANOGNB Gene at MOPED

Post-translational modifications for NANOGNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOGNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOGNB Gene

Domains & Families for NANOGNB Gene

Protein Domains for NANOGNB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOGNB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5D8

UniProtKB/Swiss-Prot:

NANGN_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with NANOGNB: view

No data available for Gene Families for NANOGNB Gene

Function for NANOGNB Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NANOGNB Gene

Localization for NANOGNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOGNB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOGNB Gene COMPARTMENTS Subcellular localization image for NANOGNB gene
Compartment Confidence
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for NANOGNB Gene

Pathways & Interactions for NANOGNB Gene

SuperPathways for NANOGNB Gene

No Data Available

Interacting Proteins for NANOGNB Gene

Gene Ontology (GO) - Biological Process for NANOGNB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NANOGNB Gene

Drugs & Compounds for NANOGNB Gene

No Compound Related Data Available

Transcripts for NANOGNB Gene

mRNA/cDNA for NANOGNB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOGNB Gene

NANOG neighbor homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NANOGNB Gene

No ASD Table

Relevant External Links for NANOGNB Gene

GeneLoc Exon Structure for
NANOGNB
ECgene alternative splicing isoforms for
NANOGNB

Expression for NANOGNB Gene

mRNA expression in normal human tissues for NANOGNB Gene

mRNA differential expression in normal tissues according to GTEx for NANOGNB Gene

This gene is overexpressed in Testis (x53.0).

SOURCE GeneReport for Unigene cluster for NANOGNB Gene Hs.558004

genes like me logo Genes that share expression patterns with NANOGNB: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NANOGNB Gene

Orthologs for NANOGNB Gene

This gene was present in the common ancestor of mammals.

Orthologs for NANOGNB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOGNB 35
  • 98.76 (n)
  • 97.87 (a)
NANOGNB 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANOGNB 36
  • 52 (a)
OneToOne
NANOGNB 35
  • 74.49 (n)
  • 56.52 (a)
Species with no ortholog for NANOGNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOGNB Gene

ENSEMBL:
Gene Tree for NANOGNB (if available)
TreeFam:
Gene Tree for NANOGNB (if available)

Paralogs for NANOGNB Gene

Pseudogenes.org Pseudogenes for NANOGNB Gene

genes like me logo Genes that share paralogs with NANOGNB: view

No data available for Paralogs for NANOGNB Gene

Variants for NANOGNB Gene

Sequence variations from dbSNP and Humsavar for NANOGNB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4883057 -- 7,771,905(+) tgtga(A/G)cctcc intron-variant
rs7135683 -- 7,763,380(+) gagcc(A/T)ccgca upstream-variant-2KB
rs11055677 -- 7,769,850(+) GCTCT(A/G)TGTTT intron-variant
rs11829053 -- 7,768,015(+) gcccc(C/T)gctta intron-variant
rs12309331 -- 7,768,828(+) cgccc(A/G)gccGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NANOGNB Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
esv2422393 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv1354n71 CNV Gain 21882294
nsv8897 CNV Gain 18304495
dgv456e1 CNV Complex 17122850

Variation tolerance for NANOGNB Gene

Gene Damage Index Score: 2.10; 38.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOGNB Gene

HapMap Linkage Disequilibrium report
NANOGNB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOGNB Gene

Disorders for NANOGNB Gene

Relevant External Links for NANOGNB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOGNB

No disorders were found for NANOGNB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NANOGNB Gene

Publications for NANOGNB Gene

  1. The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages. (PMID: 21679462) Zhong Y.F. … Holland P.W. (BMC Evol. Biol. 2011) 2 3 67
  2. Transcriptional regulatory network of SOX4 during myoblast differentiation. (PMID: 25969425) Jang S.M. … Choi K.H. (Biochem. Biophys. Res. Commun. 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NANOGNB Gene

Sources for NANOGNB Gene

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