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Aliases &
Descriptions
for NANOG
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| FLJ12581 1 | | FLJ40451 1 | | hNanog 3 |
| | | Descriptions |
|---|
| Homeobox transcription factor Nanog 2, 3 | | Nanog homeobox 2 | | homeobox transcription factor Nanog-delta 48 2 |
|
| |
Search outside databases for aliases for NANOG genePrevious GC identifers: GC12P007842 GC12U900534 |
Summaries
for NANOG(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells
proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their
differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone
morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with
SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional
complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds
optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By
similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By
similarity)Gene Wiki entry for NANOG (Homeobox_protein_NANOG) |
Genomic Location
for NANOG
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the NANOG gene 
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31NANOG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P007833:
(about GC identifiers)
Start:
|
7,833,262 bp from pter |
End:
|
7,839,922 bp from pter |
Size:
|
6,661 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009714.16
| Proteins
for NANOG
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0 (See
protein sequence)Recommended Name: Homeobox protein NANOG Size: 305 amino acids; 34620 Da
Subunit: Interacts with SMAD1 and SALL4 (By similarity)
Subcellular location: Nucleus
Developmental stage: Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner
cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein
level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at
protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES
differentiation
Miscellaneous: Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other
NANOG-related nucleotide sequences located on different chromosomes, all of which are processed
pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene
Secondary accessions: Q2TTG0 Q6JZS5Alternative splicing: 2 isoforms: Q9H9S0-1 Q9H9S0-2 REFSEQ proteins: NP_079141.2
ENSEMBL proteins: ENSP00000229307
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for NANOG:
Assays for NANOG: | Protein
Domains/
Families
for NANOG(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H9S0
ProtoNet protein and cluster: Q9H9S0 UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0Similarity: Belongs to the Nanog homeobox familySimilarity: Contains 1 homeobox DNA-binding domain | Gene Function
for NANOG
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024865
 Applied Biosystems Silencer® siRNAs for NANOG
 Sigma-Aldrich siRNA for NANOG
Sigma-Aldrich shRNA Panels and shRNA for NANOG
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_024865
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024865
untagged cDNA clone in CMV expression vector: NM_024865
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_024865
UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells
proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their
differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone
morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with
SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional
complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds
optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By
similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By
similarity)3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nanog):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for NANOG
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for NANOG (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for NANOG
5/38 Interacting proteins for NANOG (ENSP000002293073) via UniProtKB, MINT, and/or STRING (see all 38
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for NANOG(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NANOG
|
Transcripts
for NANOG(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024865
Sigma-Aldrich siRNA for NANOG
Sigma-Aldrich shRNA Panels and shRNA for NANOG
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_024865 REFSEQ mRNAs for NANOG gene: NM_024865.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024865
OriGene GFP tagged cDNA clone in CMV expression vector: NM_024865
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024865
untagged cDNA clone in CMV expression vector: NM_024865
Additional cDNA sequence: AB093576.1 AK022643.1 AK097770.1 AK290896.1 AY230262.1 AY455283.1 AY578089.1 BC098275.1 BC099704.1 7 DOTS entries: DT.407161 DT.100725442 DT.91650532 DT.75121626 DT.121074063 DT.422791 DT.121207297
 highest scoring ESTs for NANOG:AB093576 AK022643 AY230262 BF893620 BF895126 CD642640 AY578089 BX108731 CX163754 CX786835 Unigene Cluster for NANOG: Nanog homeobox Hs.661360 [show with all ESTs]Unigene Representative Sequence: AB093576
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000229307
|
Expression
for NANOG
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NANOG expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NANOG
1 / 2 / 3 3 probe-sets matching NANOG gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.661360
UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0Tissue specificity: Expressed in testicular carcinoma and derived germ cell tumors (at protein
level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell
line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes |
Orthologs
for NANOG
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NANOG gene from 5 species
About this table Species with no ortholog for NANOG
ENSEMBL Gene Tree for NANOG | Paralogs
for NANOG(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NANOG gene
- NANOGP12
Pseudogenes
- 7 related pseudogenes
|
SNPs/Variants
for NANOG(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NANOG (up to first 250kb)
|
Disorders & Mutations
for NANOG
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607937
|
Medical News
for NANOG(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NANOG (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/74 PubMed articles for NANOG gene (see all 74
):- The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PubMed id 12787504)2, 3, 4 Mitsui K....Yamanaka S. (2003)
- Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (PubMed id 12787505)2, 3, 4 Chambers I....Smith A. (2003)
- Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PubMed id 15108323)1, 3, 4 Hart A.H.... Robb L. (2004)
- Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. (PubMed id 15983365)1, 3, 4 Hyslop L.A.... Lako M. (2005)
- Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PubMed id 14990856)1, 3, 4 Clark A.T.... Reijo Pera R.A. (2004)
- Pluripotential competence of cells associated with Nanog activity. (PubMed id 15582778)3, 4 Hatano S.Y.... Tada T. (2005)
- Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. (PubMed id 15982323)3, 4 Hoei-Hansen C.E.... Rajpert-De Meyts E. (2005)
- Identification of a putative transactivation domain in human Nanog. (PubMed id 16000880)3, 4 Oh J.-H....Kim J.-H. (2005)
- Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. (PubMed id 16391521)3, 4 Kim J.S.... Chung I.Y. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
|
Search for NANOG
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NANOG
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NANOG
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NANOG(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Nanog |
|
| | | About This Section
| --
| Services
for NANOG(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for NANOG:
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