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Aliases for NANOG Gene

Aliases for NANOG Gene

  • Nanog Homeobox 2 3
  • Homeobox Transcription Factor Nanog 4
  • HNanog 4

External Ids for NANOG Gene

Previous GeneCards Identifiers for NANOG Gene

  • GC12P007842
  • GC12P007833
  • GC12U900534
  • GC12P007941
  • GC12P007940

Summaries for NANOG Gene

GeneCards Summary for NANOG Gene

NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with NANOG include ovarian germ cell tumor and sacrococcygeal teratoma. Among its related pathways are Proteoglycans in cancer and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity.

UniProtKB/Swiss-Prot for NANOG Gene

  • Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Gene Wiki entry for NANOG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOG Gene

Genomics for NANOG Gene

Regulatory Elements for NANOG Gene

Genomic Location for NANOG Gene

Start:
7,787,794 bp from pter
End:
7,799,141 bp from pter
Size:
11,348 bases
Orientation:
Plus strand

Genomic View for NANOG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NANOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOG Gene

Proteins for NANOG Gene

  • Protein details for NANOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S0-NANOG_HUMAN
    Recommended name:
    Homeobox protein NANOG
    Protein Accession:
    Q9H9S0
    Secondary Accessions:
    • D3DUU4
    • Q2TTG0
    • Q6JZS5

    Protein attributes for NANOG Gene

    Size:
    305 amino acids
    Molecular mass:
    34620 Da
    Quaternary structure:
    • Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 (By similarity).
    Miscellaneous:
    • Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene

    Three dimensional structures from OCA and Proteopedia for NANOG Gene

    Alternative splice isoforms for NANOG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOG Gene

Proteomics data for NANOG Gene at MOPED

Post-translational modifications for NANOG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for NANOG Gene

Domains for NANOG Gene

Gene Families for NANOG Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for NANOG Gene

Suggested Antigen Peptide Sequences for NANOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9S0

UniProtKB/Swiss-Prot:

NANOG_HUMAN :
  • Q9H9S0
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Nanog homeobox family.
genes like me logo Genes that share domains with NANOG: view

Function for NANOG Gene

Molecular function for NANOG Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Gene Ontology (GO) - Molecular Function for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001158 enhancer sequence-specific DNA binding --
GO:0003677 DNA binding IDA 16153702
GO:0003682 chromatin binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 16153702
GO:0003714 transcription corepressor activity ISS --
genes like me logo Genes that share ontologies with NANOG: view
genes like me logo Genes that share phenotypes with NANOG: view

Animal Model Products

Targeting motifs for NANOG Gene
HOMER Transcription Factor Regulatory Elements motif NANOG
  • Consensus sequence: GGCCATTAAC Submotif: canonical Cell Type: mES GeoId: GSE11724

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANOG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targeting for NANOG Gene

Localization for NANOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOG Gene COMPARTMENTS Subcellular localization image for NANOG gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18932205
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 20458727
genes like me logo Genes that share ontologies with NANOG: view

Pathways for NANOG Gene

genes like me logo Genes that share pathways with NANOG: view

PCR Array Products

Gene Ontology (GO) - Biological Process for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter --
GO:0001710 mesodermal cell fate commitment --
GO:0001714 endodermal cell fate specification IDA 20713518
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 16153702
genes like me logo Genes that share ontologies with NANOG: view

Transcripts for NANOG Gene

mRNA/cDNA for NANOG Gene

(10) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOG Gene

Nanog homeobox:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NANOG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOG Gene

No ASD Table

Relevant External Links for NANOG Gene

GeneLoc Exon Structure for
NANOG
ECgene alternative splicing isoforms for
NANOG

Expression for NANOG Gene

mRNA expression in normal human tissues for NANOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOG Gene

This gene is overexpressed in Testis (5.7).

SOURCE GeneReport for Unigene cluster for NANOG Gene Hs.635882

mRNA Expression by UniProt/SwissProt for NANOG Gene

Q9H9S0-NANOG_HUMAN
Tissue specificity: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.
genes like me logo Genes that share expressions with NANOG: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for NANOG Gene

Orthologs for NANOG Gene

This gene was present in the common ancestor of chordates.

Orthologs for NANOG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NANOG 35
  • 78.93 (n)
  • 70.9 (a)
NANOG 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANOG 35
  • 79.59 (n)
  • 70.31 (a)
NANOG 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nanog 35
  • 73.33 (n)
  • 61.03 (a)
Nanog 16
Nanog 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NANOG 35
  • 99.23 (n)
  • 98.36 (a)
NANOG 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nanog 35
  • 73.97 (n)
  • 64.73 (a)
oppossum
(Monodelphis domestica)
Mammalia NANOG 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
NANOG 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NANOG 36
  • 23 (a)
OneToOne
Species with no ortholog for NANOG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOG Gene

ENSEMBL:
Gene Tree for NANOG (if available)
TreeFam:
Gene Tree for NANOG (if available)

Paralogs for NANOG Gene

Selected SIMAP similar genes for NANOG Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NANOG: view

No data available for Paralogs for NANOG Gene

Variants for NANOG Gene

Sequence variations from dbSNP and Humsavar for NANOG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs877716 -- 7,794,263(+) GACAC(A/G)GTGTT intron-variant
rs877717 -- 7,794,154(+) CTGCA(A/G)CCTTC intron-variant
rs1108032 -- 7,794,152(+) CACTG(C/T)AGCCT intron-variant
rs1860931 -- 7,794,421(-) TATTC(A/G)TAATA intron-variant
rs1894825 -- 7,791,005(-) CGACT(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NANOG Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
esv2422393 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv1354n71 CNV Gain 21882294
dgv456e1 CNV Complex 17122850
nsv7227 OTHER Inversion 18451855
esv2745493 CNV Deletion 23290073
dgv457e1 CNV Complex 17122850
nsv596 CNV Insertion 18451855

Relevant External Links for NANOG Gene

HapMap Linkage Disequilibrium report
NANOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOG Gene

Disorders for NANOG Gene

(3) University of Copenhagen DISEASES for NANOG Gene

Relevant External Links for NANOG

Genetic Association Database (GAD)
NANOG
genes like me logo Genes that share disorders with NANOG: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NANOG Gene

Publications for NANOG Gene

  1. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PMID: 14990856) Clark A.T. … Reijo Pera R.A. (Stem Cells 2004) 3 4 23
  2. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PMID: 15108323) Hart A.H. … Robb L. (Dev. Dyn. 2004) 3 4 23
  3. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. (PMID: 15983365) Hyslop L.A. … Lako M. (Stem Cells 2005) 3 4 23
  4. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PMID: 12787504) Mitsui K. … Yamanaka S. (Cell 2003) 2 3 4
  5. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (PMID: 12787505) Chambers I. … Smith A. (Cell 2003) 2 3 4

Products for NANOG Gene

  • Addgene plasmids for NANOG

Sources for NANOG Gene

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