Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NANOG Gene

protein-coding   GIFtS: 60
GCID: GC12P007940

Nanog Homeobox

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nanog Homeobox1 2
Homeobox Transcription Factor Nanog2 3
hNanog2 3
Homeobox Protein NANOG2
Homeobox Transcription Factor Nanog-Delta 482

External Ids:    HGNC: 208571   Entrez Gene: 799232   Ensembl: ENSG000001117047   OMIM: 6079375   UniProtKB: Q9H9S03   

Export aliases for NANOG gene to outside databases

Previous GC identifers: GC12P007842 GC12P007833 GC12U900534 GC12P007941


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NANOG Gene: 
NANOG (Nanog homeobox) is a protein-coding gene. Diseases associated with NANOG include sacrococcygeal teratoma, and brain cancer, and among its related super-pathways are GSK3 Signaling and Wnt Signaling Pathway. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0
Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and
self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm
and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by
physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD
transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus
sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in
differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to
recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to
enter into S phase and proliferation

Gene Wiki entry for NANOG (Homeobox protein NANOG) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NANOG gene promoter:
         p53   HNF-4alpha2   E4BP4   Gfi-1   HNF-4alpha1   AREB6   POU2F1   POU2F1a   STAT3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANOG promoter sequence
   Search SABiosciences Chromatin IP Primers for NANOG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

NANOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007940:  view genomic region     (about GC identifiers)

Start:
7,940,390 bp from pter      End:
7,948,655 bp from pter
Size:
8,266 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0 (See protein sequence)
Recommended Name: Homeobox protein NANOG  
Size: 305 amino acids; 34620 Da
Subunit: Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 (By similarity)
Subcellular location: Nucleus
Developmental stage: Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM)
of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in
oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem
cells (ES). Expression decreases with ES differentiation
Miscellaneous: Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related
nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns
(NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene
1 PDB 3D structure from and Proteopedia for NANOG:
2KT0 (3D)    
Secondary accessions: D3DUU4 Q2TTG0 Q6JZS5
Alternative splicing: 2 isoforms:  Q9H9S0-1   Q9H9S0-2   

Explore the universe of human proteins at neXtProt for NANOG: NX_Q9H9S0

Explore proteomics data for NANOG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H9S0

  • NANOG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NANOG Protein Expression
    REFSEQ proteins: NP_079141.2  
    ENSEMBL proteins: 
     ENSP00000444434   ENSP00000229307   ENSP00000433428   ENSP00000435288  

    Human Recombinant Protein Products for NANOG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NANOG
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NANOG
    GenScript Purified and Recombinant Proteins for NANOG
    Novus Biologicals NANOG Proteins
    Novus Biologicals NANOG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NANOG
    Cloud-Clone Corp. Proteins for NANOG 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18932205
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IDA--

    NANOG for ontologies           About GeneDecksing



    NANOG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NANOG
    R&D Systems Antibodies for NANOG
    OriGene Antibodies for NANOG
    OriGene Custom Antibody Services for NANOG
    GenScript Custom Superior Antibodies Services for NANOG
    Novus Biologicals NANOG Antibodies
    Abcam antibodies for NANOG
    Cloud-Clone Corp. Antibodies for NANOG 
    ThermoFisher Antibody for NANOG
    LSBio Antibodies in human, mouse, rat for NANOG 

    Assay Products for NANOG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NANOG
    R&D Systems Proteome Profiler Antibody Arrays for NANOG
    GenScript Custom Assay Services for NANOG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NANOG 
    Cloud-Clone Corp. CLIAs for NANOG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    3 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H9S0

    ProtoNet protein and cluster: Q9H9S0

    UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0
    Similarity: Belongs to the Nanog homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    NANOG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NANOG_HUMAN, Q9H9S0
    Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and
    self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm
    and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by
    physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD
    transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus
    sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in
    differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to
    recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to
    enter into S phase and proliferation

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001158enhancer sequence-specific DNA binding IEA--
    GO:0003677DNA binding IDA16153702
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16153702
    GO:0003714transcription corepressor activity ISS--
         
    NANOG for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NANOG:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nanog):
     cellular  embryogenesis  mortality/aging  no phenotypic analysis 

    NANOG for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NANOG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NANOG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NANOG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NANOG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANOG
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NANOG:
    hsa-miR-7-1* hsa-miR-7-2* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidNANOG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NANOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NANOG
    Sirion Biotech Customized adenovirus for overexpression of NANOG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NANOG (see all 4)
    OriGene ORF clones in mouse, rat for NANOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANOG (NM_024865)
    Sino Biological Human cDNA Clone for NANOG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOG
    Sirion Biotech Customized lentivirus for stable overexpression of NANOG 
                         Customized lentivirus expression plasmids for stable overexpression of NANOG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NANOG
    LifeMap BioReagents: cell lines associated with NANOG: Human Embryonic Stem Cell Line ESI-017,
    Human Embryonic Stem Cell Line ESI-035, Human Embryonic Stem Cell Line ESI-049,
    Human Embryonic Stem Cell Line ESI-051, Human Embryonic Stem Cell Line ESI-053
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NANOG About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency0.55
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    4PKA activation in glucagon signalling
    Development Role of Activin A in cell differentiation and proliferation0.33
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for NANOG
        Development Role of Activin A in cell differentiation and proliferation
    Selected targets of Oct-3/4

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NANOG
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for NANOG
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for NANOG
        Development Role of Activin A in cell differentiation and proliferation

    3 BioSystems Pathways for NANOG
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Cardiac Progenitor Differentiation



    1         Kegg Pathway  (Kegg details for NANOG):
        Proteoglycans in cancer


    NANOG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NANOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for NANOG (Q9H9S03 ENSP000002293074) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=4 
    ENSG00000229094Q018603I2D: score=4 
    ENSG00000230336Q018603I2D: score=4 
    ENSG00000233911Q018603I2D: score=4 
    ENSG00000235068Q018603I2D: score=4 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001710mesodermal cell fate commitment IEA--
    GO:0001714endodermal cell fate specification IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA16153702

    NANOG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NANOG

    Search CenterWatch for drugs/clinical trials and news about NANOG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NANOG gene: 
    NM_024865.2  

    Unigene Cluster for NANOG:

    Nanog homeobox
    Hs.635882  [show with all ESTs]
    Unigene Representative Sequence: AB093576
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541267 ENST00000229307(uc009zfy.1) ENST00000526434 ENST00000526286

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NANOG
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NANOG:
    hsa-miR-7-1* hsa-miR-7-2* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidNANOG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NANOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOG
    Clone
    Products:
         
    OriGene clones in human, mouse for NANOG (see all 4)
    OriGene ORF clones in mouse, rat for NANOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANOG (NM_024865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOG
    Sirion Biotech Customized lentivirus for stable overexpression of NANOG 
                         Customized lentivirus expression plasmids for stable overexpression of NANOG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NANOG
    OriGene qSTAR qPCR primer pairs in human, mouse for NANOG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NANOG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOG

    Additional mRNA sequence: 

    AB093576.1 AK022643.1 AK097770.1 AK290896.1 AY230262.1 AY455283.1 AY578089.1 BC069807.1 
    BC098275.1 BC099704.1 

    8 DOTS entries:

    DT.407161  DT.100725442  DT.91650532  DT.75121626  DT.121074063  DT.422791  DT.121207292  DT.121207297 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NANOG expression in normal human tissues (normalized intensities)      NANOG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAATAAA
    NANOG Expression
    About this image


    NANOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 89 entries
             Inner Cell Mass Cells Inner Cell Mass
             B6 mouse embryonic stem cells
             Matrigel embedded cells ( Derivation of cardiomyocytes from pluripotent stem cells...
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 6 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cells
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 6 entries
             Trophoblast Cells Trophoblast
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 5 entries
             Zygote Zygote
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Human cardiac stem cells
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...

    See NANOG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NANOG

    SOURCE GeneReport for Unigene cluster: Hs.635882

    UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0
    Tissue specificity: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed
    in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic
    carcinoma. Not expressed in many somatic organs and oocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including NANOG: 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NANOG
    OriGene qSTAR qPCR primer pairs in human, mouse for NANOG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NANOG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NANOG gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nanog1 , 5 Nanog homeobox1, 5 72.99(n)1
    60.69(a)1
      6 (57.80 cM)5
    719501  NM_028016.21  NP_082292.11 
     1227074895 
    chicken
    (Gallus gallus)
    Aves --
    NANOG6
    nanog homeobox
    29(a)
    27(a)
    many → 1
    many → 1
    1(75359386-75361551)
    1(75366745-75371263)
    lizard
    (Anolis carolinensis)
    Reptilia NANOG6
    Nanog homeobox
    22(a)
    1 ↔ 1
    2(80930150-80939167)


    ENSEMBL Gene Tree for NANOG (if available)
    TreeFam Gene Tree for NANOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NANOG gene
    8 SIMAP similar genes for NANOG using alignment to 7 protein entries:     NANOG_HUMAN (see all proteins):
    NANOGP8    NANOGP1    NKX2-5    HOXA4    HOXB1    DLX6
    POU6F1    MNX1

    NANOG for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for NANOG (see all 9)
    PGOHUM00000238608 PGOHUM00000239310 PGOHUM00000247884 PGOHUM00000240531 PGOHUM00000243205


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 SNPs in NANOG are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167567781,2
    F--7939996(+) CCCAGC/TCCAGT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs107440441,2
    C,F,A,H--7940030(+) ACAGGG/ATTTCA 1 -- us2k14Minor allele frequency- A:0.50NA 10
    rs104506951,2
    C,F--7940096(+) GCCTCG/TCAAAG 1 -- us2k1 tfbs34Minor allele frequency- T:0.50NA 8
    rs1444612901,2
    --7940101(+) GCAAAC/GTGCTG 1 -- us2k10--------
    rs1898941201,2
    --7940128(+) CCACCA/GTGCCC 1 -- us2k10--------
    rs764179651,2
    C,F--7940237(+) CTTGGC/TGAAGA 1 -- us2k11Minor allele frequency- T:0.15WA 118
    rs1818443711,2
    --7940247(+) AATGTA/CGTAAG 1 -- us2k10--------
    rs1862721021,2
    --7940316(+) TAGACA/GCAATG 1 -- us2k10--------
    rs1479855841,2
    --7940342(+) GATGGA/GGGAAT 1 -- us2k10--------
    rs38128151,2
    C--7940444(+) GGTGAA/GTCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NANOG (7940390 - 7948655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for NANOG (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745493CNV Deletion23290073
    esv2422393CNV Duplication17116639
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639
    nsv596CNV Insertion18451855
    dgv1354n71CNV Gain21882294
    dgv57e55CNV Gain17911159
    nsv428270CNV Gain18775914
    dgv454e1CNV Complex17122850
    dgv455e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NANOG
    DNA2.0 Custom Variant and Variant Library Synthesis for NANOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607937    OMIM disorders: --

    20/32 diseases for NANOG (see all 32):    About MalaCards
    sacrococcygeal teratoma    brain cancer    teratoma    gonadoblastoma
    seminoma    teratocarcinoma    oral cancer    oral squamous cell carcinoma
    noma    germ cell tumors    medulloblastoma    gastric adenocarcinoma
    periodontitis    hypoxia    esophageal cancer    squamous cell carcinoma
    glioblastoma    neuroblastoma    cervical cancer    ovarian cancer

    3 diseases from the University of Copenhagen DISEASES database for NANOG:
    Teratoma     Embryonal carcinoma     Seminoma

    NANOG for disorders           About GeneDecksing

    Genetic Association Database (GAD): NANOG

    Export disorders for NANOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NANOG gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with NANOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (PubMed id 12787505)1, 2, 3 Chambers I....Smith A. (2003)
    2. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PubMed id 12787504)1, 2, 3 Mitsui K.... Yamanaka S. (2003)
    3. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PubMed id 15108323)1, 2, 9 Hart A.H.... Robb L. (2004)
    4. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. (PubMed id 15983365)1, 2, 9 Hyslop L.A.... Lako M. (2005)
    5. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PubMed id 14990856)1, 2, 9 Clark A.T.... Reijo Pera R.A. (2004)
    6. Identification of a putative transactivation domain in human Nanog. (PubMed id 16000880)1, 2 Oh J.-H....Kim J.-H. (2005)
    7. Pluripotential competence of cells associated with Nanog activity. (PubMed id 15582778)1, 2 Hatano S.Y.... Tada T. (2005)
    8. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. (PubMed id 15982323)1, 2 Hoei-Hansen C.E.... Rajpert-De Meyts E. (2005)
    9. Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. (PubMed id 16391521)1, 2 Kim J.S.... Chung I.Y. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79923 HGNC: 20857 Ensembl:ENSG00000111704 euGenes: HUgn79923 ECgene: NANOG Kegg: 79923
    H-InvDB: NANOG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NANOG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NANOG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Nanog

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NANOG gene:
    Search GeneIP for patents involving NANOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of NANOG
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NANOG (Nanog)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Primer Pairs for NANOG (Nanog)   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for NANOG (Nanog)  
     OriGene Antibodies for NANOG   OriGene RNAi products in human, mouse, rat for NANOG  
     OriGene qPCR primer pairs and template standards for NANOG   OriGene Protein Over-expression Lysate for NANOG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NANOG  
     OriGene qSTAR qPCR primer pairs in human, mouse for NANOG   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NANOG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NANOG   OriGene Custom Protein Services for NANOG  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NANOG
     QIAGEN SeqTarget long-range PCR primers for resequencing NANOG
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOG
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NANOG
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NANOG
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NANOG
     GenScript Purified and Recombinant Proteins for NANOG GenScript cDNA clones with any tag delivered in your preferred vector for NANOG
     GenScript Custom Assay Services for NANOG GenScript Custom Superior Antibodies Services for NANOG
     GenScript Custom overexpressing Cell Line Services for NANOG CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NANOG promoter
     Search Chromatin IP Primers for NANOG
     RT2 qPCR Primer Assay in human, mouse, rat NANOG
     GNC Network for NANOG
     SABiosciences PCR Arrays including human, mouse, rat NANOG
     Search Tocris compounds for NANOG
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NANOG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NANOG antibodies
     NANOG proteins
     NANOG lysates
     Antibodies for NANOG
     See all of Abcam's Antibodies, Kits and Proteins for NANOG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NANOG




     Proteins for NANOG
     Antibodies for NANOG
     ELISAs for NANOG
     CLIAs for NANOG
     Cell Lines associated with NANOG: Human Embryonic Stem Cell Line ESI-017,
    Human Embryonic Stem Cell Line ESI-035, Human Embryonic Stem Cell Line ESI-049,
    Human Embryonic Stem Cell Line ESI-051, Human Embryonic Stem Cell Line ESI-053
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOG
     SwitchGear 3'UTR luciferase reporter plasmids for NANOG
     SwitchGear Promoter luciferase reporter plasmids for NANOG
     ThermoFisher Antibody for NANOG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NANOG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NANOG
    Customized:
     lentivirus for stable overexpression of NANOG
     lentivirus expression plasmids for stable overexpression of NANOG
     adenovirus for overexpression of NANOG
     LSBio Antibodies in human, mouse, rat for NANOG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NANOG gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4