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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NANOG Gene

protein-coding GIFtS: 57
GCID: GC12P007940

Nanog homeobox

Explore 27 diseases affiliated with
NANOG via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nanog Homeobox¹ ²		FLJ40451¹
Homeobox Transcription Factor Nanog² ³		Homeobox Protein NANOG²
HNanog¹		Homeobox Transcription Factor Nanog-Delta 48²
FLJ12581¹

External Ids:	HGNC: 20857¹	Entrez Gene: 79923²	Ensembl: ENSG00000111704⁷	OMIM: 607937⁵	UniProtKB: Q9H9S0³

Export aliases for NANOG gene to outside databases

Previous GC identifers: GC12P007842 GC12P007833 GC12U900534 GC12P007941

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0

Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and

self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and

trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically

interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional

complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence

5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES)

cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex

and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation

Gene Wiki entry for NANOG (Homeobox protein NANOG)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NANOG gene promoter:
p53 HNF-4alpha2 E4BP4 Gfi-1 HNF-4alpha1 AREB6 POU2F1 POU2F1a STAT3 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NANOG promoter sequence

Search SABiosciences Chromatin IP Primers for NANOG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NANOG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

NANOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOG gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P007940: view genomic region (about GC identifiers)

Start:	7,940,390 bp from pter	End:	7,948,655 bp from pter
Size:	8,266 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0 (See protein sequence)

Recommended Name: Homeobox protein NANOG

Size: 305 amino acids; 34620 Da

Subunit: Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 (By similarity)

Subcellular location: Nucleus

Developmental stage: Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of

the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes,

unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES).

Expression decreases with ES differentiation

Miscellaneous: Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related

nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2

to NANOGP11); except NANOGP8 which is a retrogene

1 PDB 3D structure from and Proteopedia for NANOG:

2KT0 (3D)

Secondary accessions: D3DUU4 Q2TTG0 Q6JZS5

Alternative splicing: 2 isoforms: Q9H9S0-1 Q9H9S0-2

Explore the universe of human proteins at neXtProt for NANOG: NX_Q9H9S0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H9S0

NANOG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079141.2

ENSEMBL proteins:

ENSP00000444434 ENSP00000229307 ENSP00000433428 ENSP00000435288

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NANOG OriGene Custom Protein Services for NANOG
	GenScript Purified and Recombinant Proteins for NANOG
	Novus Biologicals NANOG Proteins Novus Biologicals NANOG Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NANOG
	Uscn Proteins for NANOG

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18932205
GO:0005730	nucleolus	IDA	--

NANOG for ontologies About GeneDecksing

NANOG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NANOG
	R&D Systems Antibodies for NANOG
	OriGene Antibodies (see all 6): NANOG OriGene Custom Antibody Services for NANOG
	GenScript Custom Superior Antibodies Services for NANOG
	Novus Biologicals NANOG Antibodies
	Abcam antibodies for NANOG
	Uscn Antibodies for NANOG
	ThermoFisher Antibodies for NANOG

Assay Products for NANOG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for NANOG
	GenScript Custom Assay Services for NANOG
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NANOG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NANOG for domains About GeneDecksing

3 InterPro domains/families:

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9H9S0

ProtoNet protein and cluster: Q9H9S0

UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0

Similarity: Belongs to the Nanog homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: