External Ids for NANOG Gene
Previous GeneCards Identifiers for NANOG Gene
GeneCards Summary for NANOG Gene
NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with NANOG include ovarian germ cell tumor and sacrococcygeal teratoma. Among its related pathways are Proteoglycans in cancer and Ca-dependent events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity.
UniProtKB/Swiss-Prot for NANOG Gene
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.