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NANOG Gene

protein-coding   GIFtS: 62
GCID: GC12P007940

Nanog Homeobox

  See NANOG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nanog Homeobox1 2
Homeobox Transcription Factor Nanog2 3
hNanog2 3
Homeobox Protein NANOG2
Homeobox Transcription Factor Nanog-Delta 482

External Ids:    HGNC: 208571   Entrez Gene: 799232   Ensembl: ENSG000001117047   OMIM: 6079375   UniProtKB: Q9H9S03   

Export aliases for NANOG gene to outside databases

Previous GC identifers: GC12P007842 GC12P007833 GC12U900534 GC12P007941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NANOG Gene:
NANOG (Nanog homeobox) is a protein-coding gene. Diseases associated with NANOG include sacrococcygeal teratoma, and ovarian germ cell tumor. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0
Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and
self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm
and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by
physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD
transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus
sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in
differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to
recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to
enter into S phase and proliferation

Gene Wiki entry for NANOG (Homeobox protein NANOG) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NANOG gene promoter:
         p53   HNF-4alpha2   E4BP4   Gfi-1   HNF-4alpha1   AREB6   POU2F1   POU2F1a   STAT3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNANOG promoter sequence
   Search Chromatin IP Primers for NANOG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NANOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

NANOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NANOG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007940:  view genomic region     (about GC identifiers)

Start:
7,940,390 bp from pter      End:
7,948,655 bp from pter
Size:
8,266 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0 (See protein sequence)
Recommended Name: Homeobox protein NANOG  
Size: 305 amino acids; 34620 Da
Subunit: Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 (By similarity)
Developmental stage: Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM)
of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in
oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem
cells (ES). Expression decreases with ES differentiation
Miscellaneous: Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related
nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns
(NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene
1 PDB 3D structure from and Proteopedia for NANOG:
2KT0 (3D)    
Secondary accessions: D3DUU4 Q2TTG0 Q6JZS5
Alternative splicing: 2 isoforms:  Q9H9S0-1   Q9H9S0-2   

Explore the universe of human proteins at neXtProt for NANOG: NX_Q9H9S0

Explore proteomics data for NANOG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NANOG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079141.2  
    ENSEMBL proteins: 
     ENSP00000444434   ENSP00000229307   ENSP00000433428   ENSP00000435288  
    Reactome Protein details: Q9H9S0

    NANOG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for NANOG
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    OriGene Custom Protein Services for NANOG
    GenScript Purified and Recombinant Proteins for NANOG
    Novus Biologicals NANOG Proteins
    Novus Biologicals NANOG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NANOG
    Cloud-Clone Corp. Proteins for NANOG

     
    Search eBioscience for Proteins for NANOG 

     
    antibodies-online proteins for NANOG (17 products) 

     
    antibodies-online peptides for NANOG

    NANOG Antibody Products:

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    Abcam antibodies for NANOG
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    ThermoFisher Antibody for NANOG
    antibodies-online antibodies for NANOG (188 products) 

    NANOG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NANOG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NANOG
    Cloud-Clone Corp. CLIAs for NANOG
    Search eBioscience for ELISAs for NANOG 
    antibodies-online kits for NANOG (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    3 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H9S0

    ProtoNet protein and cluster: Q9H9S0

    UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0
    Similarity: Belongs to the Nanog homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with NANOG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NANOG_HUMAN, Q9H9S0
    Function: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and
    self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm
    and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by
    physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD
    transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus
    sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in
    differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to
    recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to
    enter into S phase and proliferation

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001158enhancer sequence-specific DNA binding IEA--
    GO:0003677DNA binding IDA16153702
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16153702
    GO:0003714transcription corepressor activity ISS--
         
    Find genes that share ontologies with NANOG           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NANOG:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nanog):
     cellular  embryogenesis  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with NANOG           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NANOG

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GGCCATTAAC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NANOG:
    hsa-mir-145-5p (MIRT035522), hsa-mir-34b-3p (MIRT006229), hsa-mir-34a-5p (MIRT006222), hsa-mir-335-5p (MIRT017305), hsa-mir-181a-3p (MIRT007216), hsa-mir-34c-5p (MIRT006228), hsa-mir-320a (MIRT044412)

    Block miRNA regulation of human, mouse, rat NANOG using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NANOG:
    hsa-miR-7-1* hsa-miR-7-2* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidNANOG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NANOG
    Predesigned siRNA for gene silencing in human, mouse, rat NANOG

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NANOG

    Clone
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    OriGene clones in human, mouse for NANOG (see all 6)
    OriGene ORF clones in mouse, rat for NANOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NANOG (NM_024865)
    Sino Biological Human cDNA Clone for NANOG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOG
    Addgene plasmids for NANOG 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NANOG
    ESI BIO Cell Lines for NANOG: 
    Human Embryonic Stem Cell Line ESI-017, Human Embryonic Stem Cell Line ESI-035,
    Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
    Human Embryonic Stem Cell Line ESI-053
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOG

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11987 VA6-11054) for NANOG 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NANOG_HUMAN, Q9H9S0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18932205
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with NANOG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NANOG About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    4Ca-dependent events
    Development Role of Activin A in cell differentiation and proliferation0.32
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch


    Find genes that share SuperPaths with NANOG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NANOG
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for NANOG
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for NANOG
        Development Role of Activin A in cell differentiation and proliferation

    3 BioSystems Pathways for NANOG
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Cardiac Progenitor Differentiation


    3 Reactome Pathways for NANOG
        POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
    Transcriptional regulation of pluripotent stem cells
    POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation


    1 Kegg Pathway  (Kegg details for NANOG):
        Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NANOG: 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NANOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NANOG (Q9H9S03 ENSP000002293074) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603, ENSP000003730164I2D: score=4 STRING: ENSP00000373016
    ENSG00000229094Q018603, ENSP000003888424I2D: score=4 STRING: ENSP00000388842
    ENSG00000230336Q018603, ENSP000004000474I2D: score=4 STRING: ENSP00000400047
    ENSG00000233911Q018603, ENSP000003928774I2D: score=4 STRING: ENSP00000392877
    ENSG00000235068Q018603, ENSP000004050414I2D: score=4 STRING: ENSP00000405041
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001710mesodermal cell fate commitment IEA--
    GO:0001714endodermal cell fate specification IDA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA16153702

    Find genes that share ontologies with NANOG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NANOG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NANOG gene: 
    NM_024865.2  

    Unigene Cluster for NANOG:

    Nanog homeobox
    Hs.635882  [show with all ESTs]
    Unigene Representative Sequence: AB093576
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541267 ENST00000229307(uc009zfy.1) ENST00000526434 ENST00000526286

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate NANOG:
    hsa-miR-7-1* hsa-miR-7-2* hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidNANOG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NANOG
    Clone
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    GenScript: all cDNA clones in your preferred vector: NANOG (NM_024865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NANOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NANOG
    Addgene plasmids for NANOG 
    Primer
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    OriGene qPCR primer pairs and template standards for NANOG
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANOG
      QuantiTect SYBR Green Assays in human, mouse, rat NANOG
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    Flow Cytometry
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    Additional mRNA sequence: 

    AB093576.1 AK022643.1 AK097770.1 AK290896.1 AY230262.1 AY455283.1 AY578089.1 BC069807.1 
    BC098275.1 BC099704.1 

    8 DOTS entries:

    DT.407161  DT.100725442  DT.91650532  DT.75121626  DT.121074063  DT.422791  DT.121207292  DT.121207297 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NANOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAATAAA
    NANOG Expression
    About this image


    NANOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 35) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 95 entries
             Inner Cell Mass Cells Inner Cell Mass
             CA2
             Matrigel embedded cells
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 6 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cells
             Epiblast-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 8 entries
             Human cardiac stem cells
             Cardiomyocyte-like cells
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Cord Blood
             Placenta-derived mesenchymal stem cells
             Mesenchymal stem cells
     
     Gonad
             Oogonia Ovigerous Cord
             Primordial germ cell-like cells
    NANOG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NANOG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.635882

    UniProtKB/Swiss-Prot: NANOG_HUMAN, Q9H9S0
    Tissue specificity: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed
    in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic
    carcinoma. Not expressed in many somatic organs and oocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NANOG: 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for NANOG
    OriGene qSTAR qPCR primer pairs in human, mouse for NANOG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NANOG
    QuantiTect SYBR Green Assays in human, mouse, rat NANOG
    QuantiFast Probe-based Assays in human, mouse, rat NANOG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NANOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NANOG gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nanog1 , 5 Nanog homeobox1, 5 73.33(n)1
    61.03(a)1
      6 (57.80 cM)5
    719501  NM_028016.21  NP_082292.11 
     1227074895 
    chicken
    (Gallus gallus)
    Aves --
    NANOG6
    Gallus gallus nanog homeobox (NANOG), mRNA.
    26(a)
    23(a)
    many → 1
    many → 1
    1(75359386-75361551)
    1(75366745-75371263)
    lizard
    (Anolis carolinensis)
    Reptilia NANOG6
    Nanog homeobox
    23(a)
    1 ↔ 1
    2(80930150-80939167)


    ENSEMBL Gene Tree for NANOG (if available)
    TreeFam Gene Tree for NANOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NANOG gene
    8 SIMAP similar genes for NANOG using alignment to 7 protein entries:     NANOG_HUMAN (see all proteins):
    NANOGP8    NANOGP1    NKX2-5    HOXA4    HOXB1    DLX6
    POU6F1    MNX1

    Find genes that share paralogs with NANOG           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for NANOG (see all 9)
    PGOHUM00000238608 PGOHUM00000239310 PGOHUM00000247884 PGOHUM00000240531 PGOHUM00000243205


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NANOG (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167567781,2
    F--7939996(+) CCCAGC/TCCAGT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs107440441,2
    C,F,A,H--7940030(+) ACAGGG/ATTTCA 1 -- us2k14Minor allele frequency- A:0.50NA 10
    rs104506951,2
    C,F--7940096(+) GCCTCG/TCAAAG 1 -- us2k1 tfbs34Minor allele frequency- T:0.50NA 8
    rs1444612901,2
    --7940101(+) GCAAAC/GTGCTG 1 -- us2k10--------
    rs1898941201,2
    --7940128(+) CCACCA/GTGCCC 1 -- us2k10--------
    rs764179651,2
    C,F--7940237(+) CTTGGC/TGAAGA 1 -- us2k11Minor allele frequency- T:0.15WA 118
    rs1818443711,2
    --7940247(+) AATGTA/CGTAAG 1 -- us2k10--------
    rs1862721021,2
    --7940316(+) TAGACA/GCAATG 1 -- us2k10--------
    rs1479855841,2
    --7940342(+) GATGGA/GGGAAT 1 -- us2k10--------
    rs38128151,2
    C--7940444(+) GGTGAA/GTCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NANOG (7940390 - 7948655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NANOG (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745493CNV Deletion23290073
    esv2422393CNV Duplication17116639
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639
    nsv596CNV Insertion18451855
    dgv1354n71CNV Gain21882294
    dgv57e55CNV Gain17911159
    nsv428270CNV Gain18775914
    dgv454e1CNV Complex17122850
    dgv455e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NANOG
    DNA2.0 Custom Variant and Variant Library Synthesis for NANOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607937    OMIM disorders: --

    3 diseases for NANOG:    
    About MalaCards
    sacrococcygeal teratoma    ovarian germ cell tumor    ovarian serous cystadenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for NANOG:
    Teratoma     Embryonal carcinoma     Seminoma

    Find genes that share disorders with NANOG           About GenesLikeMe

    Genetic Association Database (GAD): NANOG

    Export disorders for NANOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NANOG gene, integrated from 10 sources (see all 212):
    (articles sorted by number of sources associating them with NANOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (PubMed id 12787505)1, 2, 3 Chambers I....Smith A. (Cell 2003)
    2. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PubMed id 12787504)1, 2, 3 Mitsui K.... Yamanaka S. (Cell 2003)
    3. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PubMed id 15108323)1, 2, 9 Hart A.H.... Robb L. (Dev. Dyn. 2004)
    4. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. (PubMed id 15983365)1, 2, 9 Hyslop L.A.... Lako M. (Stem Cells 2005)
    5. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PubMed id 14990856)1, 2, 9 Clark A.T.... Reijo Pera R.A. (Stem Cells 2004)
    6. Identification of a putative transactivation domain in human Nanog. (PubMed id 16000880)1, 2 Oh J.-H....Kim J.-H. (Exp. Mol. Med. 2005)
    7. Pluripotential competence of cells associated with Nanog activity. (PubMed id 15582778)1, 2 Hatano S.Y.... Tada T. (Mech. Dev. 2005)
    8. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. (PubMed id 15982323)1, 2 Hoei-Hansen C.E.... Rajpert-De Meyts E. (Histopathology 2005)
    9. Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. (PubMed id 16391521)1, 2 Kim J.S.... Chung I.Y. (Exp. Mol. Med. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79923 HGNC: 20857 Ensembl:ENSG00000111704 euGenes: HUgn79923 ECgene: NANOG Kegg: 79923
    H-InvDB: NANOG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NANOG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NANOG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Nanog

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NANOG gene:
    Search GeneIP for patents involving NANOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Cell Lines for NANOG: Human Embryonic Stem Cell Line ESI-017, Human Embryonic Stem Cell Line ESI-035,
    Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
    Human Embryonic Stem Cell Line ESI-053
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