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Aliases for NAMPT Gene

Aliases for NAMPT Gene

  • Nicotinamide Phosphoribosyltransferase 2 3 5
  • Pre-B-Cell Colony Enhancing Factor 1 2 3
  • Pre-B-Cell Colony-Enhancing Factor 1 3 4
  • Pre-B Cell-Enhancing Factor 3 4
  • EC 2.4.2.12 4 63
  • NAmPRTase 3 4
  • VISFATIN 3 4
  • PBEF1 3 4
  • PBEF 3 4
  • 1110035O14Rik 3
  • Visfatin 2
  • Nampt 4
  • VF 3

External Ids for NAMPT Gene

Previous HGNC Symbols for NAMPT Gene

  • PBEF1

Previous GeneCards Identifiers for NAMPT Gene

  • GC07M105675
  • GC07M105888
  • GC07M100248

Summaries for NAMPT Gene

Entrez Gene Summary for NAMPT Gene

  • This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]

GeneCards Summary for NAMPT Gene

NAMPT (Nicotinamide Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with NAMPT include gestational diabetes and idiopathic recurrent pericarditis. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include protein homodimerization activity and drug binding.

UniProtKB/Swiss-Prot for NAMPT Gene

  • Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

Tocris Summary for NAMPT Gene

Gene Wiki entry for NAMPT Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAMPT Gene

Genomics for NAMPT Gene

Regulatory Elements for NAMPT Gene

Genomic Location for NAMPT Gene

Chromosome:
7
Start:
106,248,285 bp from pter
End:
106,286,326 bp from pter
Size:
38,042 bases
Orientation:
Minus strand

Genomic View for NAMPT Gene

Genes around NAMPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAMPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAMPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAMPT Gene

Proteins for NAMPT Gene

  • Protein details for NAMPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43490-NAMPT_HUMAN
    Recommended name:
    Nicotinamide phosphoribosyltransferase
    Protein Accession:
    P43490
    Secondary Accessions:
    • A4D0Q9
    • A4D0R0
    • Q3KQV0
    • Q8WW95

    Protein attributes for NAMPT Gene

    Size:
    491 amino acids
    Molecular mass:
    55521 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAQ96862.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL24400.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAMPT Gene

neXtProt entry for NAMPT Gene

Proteomics data for NAMPT Gene at MOPED

Post-translational modifications for NAMPT Gene

  • Ubiquitination at Lys 99, Lys 189, Lys 342, and Lys 371
  • Modification sites at PhosphoSitePlus

Other Protein References for NAMPT Gene

Antibody Products

  • R&D Systems Antibodies for NAMPT (PBEF/Visfatin)
  • Cell Signaling Technology (CST) Antibodies for NAMPT (PBEF)

Domains & Families for NAMPT Gene

Protein Domains for NAMPT Gene

Suggested Antigen Peptide Sequences for NAMPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43490

UniProtKB/Swiss-Prot:

NAMPT_HUMAN :
  • Belongs to the NAPRTase family.
Family:
  • Belongs to the NAPRTase family.
genes like me logo Genes that share domains with NAMPT: view

No data available for Gene Families for NAMPT Gene

Function for NAMPT Gene

Molecular function for NAMPT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor.
UniProtKB/Swiss-Prot Function:
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

Enzyme Numbers (IUBMB) for NAMPT Gene

Gene Ontology (GO) - Molecular Function for NAMPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with NAMPT: view
genes like me logo Genes that share phenotypes with NAMPT: view

Animal Models for NAMPT Gene

MGI Knock Outs for NAMPT:

Animal Model Products

  • Taconic Biosciences Mouse Models for NAMPT

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAMPT Gene

Localization for NAMPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAMPT Gene

Nucleus. Cytoplasm. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269 PubMed:21741723, ECO:0000269 PubMed:24130902}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAMPT Gene COMPARTMENTS Subcellular localization image for NAMPT gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAMPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with NAMPT: view

Pathways & Interactions for NAMPT Gene

genes like me logo Genes that share pathways with NAMPT: view

Pathways by source for NAMPT Gene

1 GeneGo (Thomson Reuters) pathway for NAMPT Gene
1 R&D Systems pathway for NAMPT Gene

UniProtKB/Swiss-Prot P43490-NAMPT_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.

Gene Ontology (GO) - Biological Process for NAMPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8289818
GO:0007267 cell-cell signaling TAS 8289818
GO:0007565 female pregnancy IEA --
GO:0008284 positive regulation of cell proliferation TAS 8289818
GO:0008286 NOT insulin receptor signaling pathway IDA 17983582
genes like me logo Genes that share ontologies with NAMPT: view

No data available for SIGNOR curated interactions for NAMPT Gene

Drugs & Compounds for NAMPT Gene

(18) Drugs for NAMPT Gene - From: HMDB, Novoseek, ApexBio, Tocris, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 353,361
N-[4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL]-3-PYRIDIN-3-YLPROPANAMIDE Experimental Pharma Target 0
Diphosphate Experimental Pharma 0
Phosphoribosyl pyrophosphate Experimental Pharma 0
GMX1777 Investigational Pharma inhibitor, Target 0

(18) Additional Compounds for NAMPT Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Nicotinamide ribotide
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
1094-61-7
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
FK 866 hydrochloride
GPP 78 hydrochloride
genes like me logo Genes that share compounds with NAMPT: view

Drug Products

Transcripts for NAMPT Gene

Unigene Clusters for NAMPT Gene

Nicotinamide phosphoribosyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAMPT Gene

No ASD Table

Relevant External Links for NAMPT Gene

GeneLoc Exon Structure for
NAMPT
ECgene alternative splicing isoforms for
NAMPT

Expression for NAMPT Gene

mRNA expression in normal human tissues for NAMPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAMPT Gene

This gene is overexpressed in Whole Blood (x18.5).

Protein differential expression in normal tissues from HIPED for NAMPT Gene

This gene is overexpressed in Lavage (9.1) and Islet of Langerhans (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAMPT Gene



SOURCE GeneReport for Unigene cluster for NAMPT Gene Hs.489615

mRNA Expression by UniProt/SwissProt for NAMPT Gene

P43490-NAMPT_HUMAN
Tissue specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
genes like me logo Genes that share expression patterns with NAMPT: view

Protein tissue co-expression partners for NAMPT Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NAMPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAMPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAMPT 35
  • 99.66 (n)
  • 99.8 (a)
NAMPT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAMPT 36
  • 96 (a)
OneToMany
NAMPT 35
  • 94.7 (n)
  • 96.13 (a)
dog
(Canis familiaris)
Mammalia NAMPT 35
  • 93.44 (n)
  • 94.77 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nampt 36
  • 96 (a)
OneToMany
Nampt 16
Nampt 35
  • 91.38 (n)
  • 95.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nampt 35
  • 89.82 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves PBEF1 36
  • 94 (a)
OneToMany
NAMPT 35
  • 84.43 (n)
  • 94.47 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398502 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nampt 35
  • 78.51 (n)
  • 89.05 (a)
Str.8198 35
zebrafish
(Danio rerio)
Actinopterygii BX248331.2 36
  • 78 (a)
ManyToMany
CT033790.1 36
  • 78 (a)
ManyToMany
CT033790.3 36
  • 78 (a)
ManyToMany
nampta 36
  • 86 (a)
ManyToMany
namptb 36
  • 59 (a)
ManyToMany
si:dkey-145c18.2 36
  • 39 (a)
ManyToMany
si:dkey-145c18.3 36
  • 52 (a)
ManyToMany
Dr.8694 35
LOC100330160 35
  • 74.02 (n)
  • 88.24 (a)
Species with no ortholog for NAMPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAMPT Gene

ENSEMBL:
Gene Tree for NAMPT (if available)
TreeFam:
Gene Tree for NAMPT (if available)

Paralogs for NAMPT Gene

(1) SIMAP similar genes for NAMPT Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NAMPT Gene

genes like me logo Genes that share paralogs with NAMPT: view

No data available for Paralogs for NAMPT Gene

Variants for NAMPT Gene

Sequence variations from dbSNP and Humsavar for NAMPT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036614 A colorectal cancer sample
rs929604 -- 106,266,197(+) GAACA(C/T)GTGAG intron-variant
rs1065322 -- 106,249,852(+) GATGT(A/C)TGATT utr-variant-3-prime
rs978040 -- 106,281,978(+) TATGG(G/T)GCTCA intron-variant
rs1319501 -- 106,285,307(+) TGACC(C/T)GGGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAMPT Gene

Variant ID Type Subtype PubMed ID
nsv888937 CNV Loss 21882294

Variation tolerance for NAMPT Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAMPT Gene

HapMap Linkage Disequilibrium report
NAMPT
Human Gene Mutation Database (HGMD)
NAMPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAMPT Gene

Disorders for NAMPT Gene

MalaCards: The human disease database

(10) MalaCards diseases for NAMPT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gestational diabetes
  • gdm
idiopathic recurrent pericarditis
  • idiopathic relapsing pericarditis
obesity bmiq11
  • obesity, susceptibility to, bmiq11
carotid stenosis
  • carotid artery stenosis
morbid obesity
  • severe obesity
- elite association - COSMIC cancer census association via MalaCards
Search NAMPT in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAMPT

Genetic Association Database (GAD)
NAMPT
Human Genome Epidemiology (HuGE) Navigator
NAMPT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAMPT
genes like me logo Genes that share disorders with NAMPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAMPT Gene

Publications for NAMPT Gene

  1. Cloning and characterization of the cDNA encoding a novel human pre- B-cell colony-enhancing factor. (PMID: 8289818) Samal B. … McNiece I. (Mol. Cell. Biol. 1994) 2 3 4 23 67
  2. Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome. (PMID: 19111298) Ozkaya M. … Engin-Ustun Y. (Fertil. Steril. 2010) 3 23
  3. The concentrations of visfatin in the follicular fluids of women undergoing controlled ovarian stimulation are correlated to the number of oocytes retrieved. (PMID: 19200966) Shen C.J. … Chan T.F. (Fertil. Steril. 2010) 3 23
  4. The relationship of visfatin/pre-B-cell colony-enhancing factor/nicotinamide phosphoribosyltransferase in adipose tissue with inflammation, insulin resistance, and plasma lipids. (PMID: 19765775) Chang Y.C. … Chuang L.M. (Metab. Clin. Exp. 2010) 3 23
  5. Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease. (PMID: 20392873) Dahl T.B. … Halvorsen B. (J. Clin. Endocrinol. Metab. 2010) 3 23

Products for NAMPT Gene

Sources for NAMPT Gene

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