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NAMPT Gene

protein-coding   GIFtS: 68
GCID: GC07M105888

Nicotinamide Phosphoribosyltransferase

(Previous name: pre-B-cell colony enhancing factor 1)
(Previous symbol: PBEF1)
  See NAMPT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nicotinamide Phosphoribosyltransferase1 2     EC 2.4.2.123 8
PBEF11 2 3 5     VF2 5
PBEF2 3 5     visfatin1
Pre-B-Cell Colony Enhancing Factor 11 2     1110035O14Rik2
Pre-B Cell-Enhancing Factor2 3     VISFATIN2
Pre-B-Cell Colony-Enhancing Factor 12 3     Nampt3
NAmPRTase2 3     Visfatin3

External Ids:    HGNC: 300921   Entrez Gene: 101352   Ensembl: ENSG000001058357   OMIM: 6087645   UniProtKB: P434903   

Export aliases for NAMPT gene to outside databases

Previous GC identifers: GC07M105675 GC07M100248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAMPT Gene:
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate
to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The
protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved
in many important biological processes, including metabolism, stress response and aging. This gene has a
pseudogene on chromosome 10. (provided by RefSeq, Feb 2011)

GeneCards Summary for NAMPT Gene:
NAMPT (nicotinamide phosphoribosyltransferase) is a protein-coding gene. Diseases associated with NAMPT include idiopathic recurrent pericarditis, and gestational diabetes. GO annotations related to this gene include nicotinate phosphoribosyltransferase activity and cytokine activity. An important paralog of this gene is NAMPTL.

UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490
Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide
mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian
NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an
adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by
ATP, which has a low level in extracellular space and plasma

Gene Wiki entry for NAMPT (Nicotinamide phosphoribosyltransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAMPT gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-1   ATF-2   Nkx3-1 v1   Nkx3-1 v2   Max   Nkx3-1 v3   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NAMPT promoter sequence
   Search Chromatin IP Primers for NAMPT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAMPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22.3

NAMPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAMPT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M105888:  view genomic region     (about GC identifiers)

Start:
105,888,731 bp from pter      End:
105,926,772 bp from pter
Size:
38,042 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 105,249,752-105,286,646     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490 (See protein sequence)
Recommended Name: Nicotinamide phosphoribosyltransferase  
Size: 491 amino acids; 55521 Da
Subunit: Homodimer
Sequence caution: Sequence=AAQ96862.1; Type=Erroneous gene model prediction; Sequence=EAL24400.1; Type=Erroneous
gene model prediction;
Selected PDB 3D structures from and Proteopedia for NAMPT (see all 25):
2E5B (3D)        2E5C (3D)        2E5D (3D)        2GVG (3D)        2GVJ (3D)        3DGR (3D)    
Secondary accessions: A4D0Q9 A4D0R0 Q3KQV0 Q8WW95

Explore the universe of human proteins at neXtProt for NAMPT: NX_P43490

Explore proteomics data for NAMPT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys99, Lys189, Lys342, Lys371
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NAMPT (P43490) (see all 6)
     DLLHTVFKNGKVTKSYSFDE  APLIIRPDSGNPLDTVLKVL  RKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAK  AAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKK 


    See NAMPT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005737.1  
    ENSEMBL proteins: 
     ENSP00000222553   ENSP00000346242   ENSP00000390591   ENSP00000390896  
    Reactome Protein details: P43490

    NAMPT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for NAMPT
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NAMPT
    GenScript Custom Purified and Recombinant Proteins Services for NAMPT
    Novus Biologicals NAMPT Proteins
    Sino Biological Recombinant Protein for NAMPT
    Sino Biological Cell Lysate for NAMPT
    ProSpec Recombinant Protein for NAMPT
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NAMPT 

    NAMPT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NAMPT
    R&D Systems Antibodies for NAMPT (PBEF/Visfatin)
    OriGene Antibodies for NAMPT
    OriGene Custom Antibody Services for NAMPT
    Novus Biologicals NAMPT Antibodies
    Search for Antibodies for NAMPT at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NAMPT
    LSBio Antibodies in human, mouse, rat for NAMPT

    NAMPT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAMPT
    R&D Systems Proteome Profiler Antibody Arrays for NAMPT (PBEF/Visfatin)
    GenScript Custom Assay Services for NAMPT
    Enzo Life Sciences assays for NAMPT
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NAMPT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002638 Quinolinate_PRibosylTrfase_C
     IPR007229 Nic_PRibTrfase-Fam
     IPR016471 Nicotinamide_PRibTrfase

    Graphical View of Domain Structure for InterPro Entry P43490

    ProtoNet protein and cluster: P43490

    UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490
    Similarity: Belongs to the NAPRTase family


    Find genes that share domains with NAMPT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAMPT_HUMAN, P43490
    Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide
    mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian
    NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an
    adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by
    ATP, which has a low level in extracellular space and plasma
    Catalytic activity: Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose
    1-diphosphate
    Enzyme regulation: Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its
    very low dissociation rate, it is essentially an irreversible inhibitor

         Enzyme Number (IUBMB): EC 2.4.2.121 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004514nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA--
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI18486613
    GO:0047280nicotinamide phosphoribosyltransferase activity IEA--
         
    Find genes that share ontologies with NAMPT           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NAMPT:
     High actin ratio cells 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nampt):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with NAMPT           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAMPT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAMPT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAMPT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAMPT

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAMPT:
    hsa-mir-16-5p (MIRT031598), hsa-mir-155-5p (MIRT005102)

    Block miRNA regulation of human, mouse, rat NAMPT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAMPT (see all 83):
    hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-578 hsa-miR-3142 hsa-miR-556-3p hsa-miR-374b* hsa-miR-647
    SwitchGear 3'UTR luciferase reporter plasmidNAMPT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAMPT
    Predesigned siRNA for gene silencing in human, mouse, rat NAMPT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAMPT

    Clone
    Products:
         
    OriGene clones in human, mouse for NAMPT (see all 8)
    OriGene ORF clones in mouse, rat for NAMPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAMPT (NM_005746)
    Sino Biological Human cDNA Clone for NAMPT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAMPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAMPT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAMPT
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAMPT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAMPT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAMPT_HUMAN, P43490: Nucleus. Cytoplasm (By similarity). Secreted. Note=Under non-inflammatory conditions,
    visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon
    IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal
    serum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2
    peroxisome2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with NAMPT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAMPT About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    NAD salvage0.00
    NAD metabolism0.43
    Nicotinate metabolism0.00
    Nicotinamide salvaging0.00
    2Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Metabolism of vitamins and cofactors1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    3Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    4Metabolism
    Metabolism0.38
    5IL-9 Signaling Pathways
    Adipocytokines and Insulin Signaling0.34


    Find genes that share SuperPaths with NAMPT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NAMPT
        Adipocytokines & Insulin Signaling


    1 GeneGo (Thomson Reuters) Pathway for NAMPT
        NAD metabolism

    2 BioSystems Pathways for NAMPT
        Adipogenesis
    NAD salvage


    2 Reactome Pathways for NAMPT
        Nicotinamide salvaging
    BMAL1:CLOCK,NPAS2 activates circadian gene expression


    1 Kegg Pathway  (Kegg details for NAMPT):
        Nicotinate and nicotinamide metabolism

    UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose
    1-diphosphate and nicotinamide: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NAMPT (see all 6): 

              Notch Signaling Targets in human mouse rat
              Insulin Resistance in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NAMPT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAMPT (P434901, 2, 3 ENSP000002225534) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FTLP027921, 2, 3, ENSP000003665254EBI-2829310,EBI-713279 MINT-6538799 MINT-6538712 MINT-6538862 I2D: score=1 STRING: ENSP00000366525
    MT-ND1P038861, 2, 3, ENSP000003546874EBI-2829310,EBI-1246156 MINT-6538787 MINT-6538841 MINT-6538697 I2D: score=1 STRING: ENSP00000354687
    ADORA2AP292742, 3, ENSP000003366304MINT-6538741 I2D: score=1 STRING: ENSP00000336630
    UBE2L6O149332, 3, ENSP000002871564MINT-6538769 I2D: score=1 STRING: ENSP00000287156
    IFITM3Q016281, 2, 3, ENSP000003827074EBI-2829310,EBI-7932862 MINT-6538727 MINT-6538811 MINT-6538868 I2D: score=1 STRING: ENSP00000382707
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006769nicotinamide metabolic process TAS--
    GO:0007165signal transduction TAS8289818
    GO:0007267cell-cell signaling TAS8289818

    Find genes that share ontologies with NAMPT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NAMPT
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAMPT

    6 HMDB Compounds for NAMPT    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    Nicotinamide ribotide3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt (see all 15)1094-61-7--
    Phosphoribosyl pyrophosphate5-Phospho-a-D-ribose-1-diphosphate (see all 37)7540-64-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for NAMPT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-[4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL]-3-PYRIDIN-3-YLPROPANAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for NAMPT gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fk-866 93.7 17 19936064 (3), 14612543 (2), 18247435 (1), 18768589 (1) (see all 8)
    nicotinamide 87.7 187 19666527 (3), 19149599 (3), 12555668 (3), 19727662 (2) (see all 63)
    nicotinamide mononucleotide 83.4 33 16901503 (2), 18823127 (2), 16783373 (2), 19727662 (1) (see all 10)
    nad+ 72.9 88 17268245 (4), 19855187 (3), 19182797 (3), 19703994 (2) (see all 28)
    glucose 61 168 19302375 (5), 19650786 (5), 19461540 (4), 16736128 (4) (see all 66)
    prpp 52.1 3 17565174 (1), 12555668 (1)
    rosiglitazone 49.5 13 16735449 (4), 18942491 (3), 17235334 (2), 19815243 (2) (see all 6)
    niacin 48.4 5 15837705 (1), 10218108 (1), 2183889 (1)
    pioglitazone 47.3 20 17952841 (4), 17378999 (3), 18031315 (2), 19158194 (2) (see all 5)
    lipid 38.4 32 17429683 (3), 18246224 (2), 19804767 (2), 19815243 (2) (see all 22)



    Find genes that share compounds with NAMPT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAMPT gene (2 alternative transcripts): 
    NM_005746.2  NM_182790.1  

    Unigene Cluster for NAMPT:

    Nicotinamide phosphoribosyltransferase
    Hs.489615  [show with all ESTs]
    Unigene Representative Sequence: NM_005746
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222553(uc003vdq.3 uc003vdr.1 uc011klu.1) ENST00000463871
    ENST00000354289 ENST00000491027 ENST00000467730 ENST00000484527 ENST00000393618
    ENST00000441045 ENST00000486949 ENST00000489358 ENST00000424768 ENST00000489732
    ENST00000417537
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAMPT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAMPT (see all 83):
    hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-578 hsa-miR-3142 hsa-miR-556-3p hsa-miR-374b* hsa-miR-647
    SwitchGear 3'UTR luciferase reporter plasmidNAMPT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAMPT
    Predesigned siRNA for gene silencing in human, mouse, rat NAMPT
    Clone
    Products:
         
    OriGene clones in human, mouse for NAMPT (see all 8)
    OriGene ORF clones in mouse, rat for NAMPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAMPT (NM_005746)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAMPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAMPT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAMPT
    OriGene qSTAR qPCR primer pairs in human, mouse for NAMPT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAMPT
      QuantiTect SYBR Green Assays in human, mouse, rat NAMPT
      QuantiFast Probe-based Assays in human, mouse, rat NAMPT

    Additional mRNA sequence: 

    AK292851.1 AK304085.1 BC072439.1 BC106046.1 L29050.1 U02020.1 

    Selected DOTS entries (see all 35):

    DT.100703768  DT.119356  DT.100037990  DT.100883858  DT.121066768  DT.95329224  DT.100662669  DT.86852592 
    DT.100883852  DT.92036344  DT.428653  DT.97802778  DT.121066749  DT.91768071  DT.91974524  DT.92014376 
    DT.95251570  DT.121066780  DT.99961287  DT.100802957  DT.100883849  DT.100883856  DT.121066728  DT.121066757 

    Selected AceView cDNA sequences (see all 691):

    AI597881 AA171651 BQ005473 BE222290 AI401840 AA424866 AL135656 BQ433018 
    AI281901 AI655193 BX341461 BM828693 AI791419 CA447801 AW468332 BP363607 
    AA805170 BQ231611 AI811930 AA045438 BX464872 CB243198 AV651430 BE049565 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAMPT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTAACAA
    NAMPT Expression
    About this image


    NAMPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
    NAMPT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAMPT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489615

    UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490
    Tissue specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart,
    placenta, lung, and kidney tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NAMPT (see all 6): 
              Notch Signaling Targets in human mouse rat
              Insulin Resistance in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAMPT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NAMPT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nampt1 , 5 nicotinamide phosphoribosyltransferase1, 5 91.38(n)1
    95.72(a)1
      12 (13.74 cM)5
    590271  NM_021524.21  NP_067499.21 
     328203355 
    chicken
    (Gallus gallus)
    Aves NAMPT1 nicotinamide phosphoribosyltransferase 84.43(n)
    94.47(a)
      417707  NM_001030728.1  NP_001025899.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    5(96938974-96963822)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985022 similar to pre-B-cell colony-enhancing factor 79.45(n)    BC045090.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.86942 Danio rerio mRNA similar to pre-B-cell colony-enhancing more 71.5(n)    BC044476.1 


    ENSEMBL Gene Tree for NAMPT (if available)
    TreeFam Gene Tree for NAMPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAMPT gene
    NAMPTL2  
    1 SIMAP similar gene for NAMPT using alignment to 3 protein entries:     NAMPT_HUMAN (see all proteins):
    NAMPTL

    Find genes that share paralogs with NAMPT           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NAMPT
    PGOHUM00000258464 PGOHUM00000235414


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAMPT (see all 771)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366144
    A colorectal cancer sample4--see VAR_0366142 L S mis40--------
    rs1175538871,2
    F--105888295(+) CAATAC/GAGTTA 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1434769901,2
    --105888340(+) ATGGCA/GTGGGG 1 -- ds50010--------
    rs1893456151,2
    --105888342(+) GGCGTC/GGGGTT 1 -- ds50010--------
    rs1808920651,2
    --105888530(+) TAACAC/TGGGAA 1 -- ds50010--------
    rs1863865701,2
    --105888537(+) GGAATC/TGTGCT 1 -- ds50010--------
    rs1464549781,2
    C--105888593(+) AAGGCA/CCTGTC 1 -- ds50010--------
    rs1908356661,2
    --105888604(+) ATCTAC/TACAGT 1 -- ds50010--------
    rs1815944941,2
    --105888605(+) TCTATA/TCAGTT 1 -- ds50010--------
    rs758201771,2
    C--105888627(+) AAAAGG/TAGTCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NAMPT (105888731 - 105926772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NAMPT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv888937CNV Loss21882294

    Human Gene Mutation Database (HGMD): NAMPT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAMPT
    DNA2.0 Custom Variant and Variant Library Synthesis for NAMPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608764    OMIM disorders: --

    7 diseases for NAMPT:    
    About MalaCards
    idiopathic recurrent pericarditis    gestational diabetes    pericarditis    insulin resistance
    type 2 diabetes mellitus    coronary artery disease    obesity

    3 diseases from the University of Copenhagen DISEASES database for NAMPT:
    Diabetes mellitus     Atherosclerosis     Polycystic ovary syndrome

    Find genes that share disorders with NAMPT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NAMPT gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 80.8 108 17634078 (4), 16720654 (4), 20346233 (3), 19222486 (3) (see all 58)
    obesity 74.3 125 20346233 (5), 17512309 (3), 17878256 (3), 19444230 (3) (see all 53)
    insulin sensitivity 68.2 30 17327330 (3), 20151765 (3), 17586594 (2), 18803942 (2) (see all 20)
    inflammation 60.5 83 18248642 (4), 20470278 (4), 20346239 (3), 17634078 (3) (see all 42)
    polycystic ovary syndrome 54 2 18848173 (1), 19111298 (1)
    niddm 51.8 21 18691043 (2), 18246224 (1), 16401830 (1), 18686225 (1) (see all 12)
    atherosclerosis 50 16 19351806 (2), 19178507 (2), 18663287 (1), 20145358 (1) (see all 12)
    cardiovascular diseases 48.7 8 15968578 (1), 16311222 (1), 17970534 (1), 16391616 (1) (see all 8)
    diabetes gestational 48 12 16489932 (2), 18787378 (2), 16814166 (1), 17416788 (1) (see all 8)
    necrosis 43.5 33 17283255 (2), 18272217 (1), 17882804 (1), 17878891 (1) (see all 29)

    Genetic Association Database (GAD): NAMPT
    Human Genome Epidemiology (HuGE) Navigator: NAMPT (2 documents)

    Export disorders for NAMPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAMPT gene, integrated from 10 sources (see all 528):
    (articles sorted by number of sources associating them with NAMPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the cDNA encoding a novel human pre- B-cell colony-enhancing factor. (PubMed id 8289818)1, 2, 3, 9 Samal B.... McNiece I. (Mol. Cell. Biol. 1994)
    2. The visfatin (PBEF1) G-948T gene polymorphism is associated with increased high-density lipoprotein cholesterol in obese subjects. (PubMed id 18940394)1, 4, 9 Johansson L.M....RidderstrAYle M. (Metab. Clin. Exp. 2008)
    3. Genetic variant in visfatin gene promoter is associated with decreased risk of coronary artery disease in a Chinese population. (PubMed id 19804767)1, 4, 9 Yan J.J....Huang J. ( international journal of clinical chemistry 2010)
    4. A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. (PubMed id 19300429)1, 4, 9 Blakemore A.I....Walley A.J. (Obesity (Silver Spring) 2009)
    5. Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. (PubMed id 16783377)1, 2, 9 Khan J.A.... Tong L. (Nat. Struct. Mol. Biol. 2006)
    6. The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects. (PubMed id 18270432)1, 4 Tokunaga A....Yamagata K. (Endocr. J. 2008)
    7. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10135 HGNC: 30092 AceView: PBEF1 Ensembl:ENSG00000105835 euGenes: HUgn10135
    ECgene: NAMPT Kegg: 10135 H-InvDB: NAMPT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAMPT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAMPT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAMPT gene:
    Search GeneIP for patents involving NAMPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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