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NAMPT Gene

protein-coding GIFtS: 57

GC07M105675

nicotinamide phosphoribosyltransferase
(Previous name: pre-B-cell colony enhancing factor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PBEF1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
1110035O14Rik ^²
DKFZp666B131 ^²
EC 2.4.2.12 ^³
MGC117256 ^²
NAmPRTase ^², ³
Nampt ^³
PBEF ^², ³, ⁵
PBEF1 ^², ³, ⁵
VF ^², ⁵
VISFATIN ^²
Visfatin ^³

Descriptions
Pre-B cell-enhancing factor ^², ³
Pre-B-cell colony-enhancing factor 1 ^³
nicotinamide phosphoribosyltransferase ^²
pre-B-cell colony enhancing factor 1 ^¹, ²

External Ids
HGNC: 30092¹
Entrez Gene: 10135²
UniProtKB: P43490³
Ensembl: ENSG00000105835⁷

Search outside databases for aliases for NAMPT gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAMPT:

This gene encodes a protein that catalyzes the condensation of nicotinamide with

5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the

biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized

to the bloodstream and has various functions, including the promotion of vascular smooth muscle

cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has

insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is

highly expressed in visceral fat and serum levels of the protein correlate with obesity. This gene

has a pseudogene on chromosome 10. [provided by RefSeq]

UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490

Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield

nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting

component in the mammalian NAD biosynthesis pathway (By similarity)

Gene Wiki entry for NAMPT (PBEF1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.2 Ensembl cytogenetic band: 7q22.2 HGNC cytogenetic band: 7q22.2

NAMPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M105675: (about GC identifiers)

Start:	105,675,967 bp from pter
End:	105,712,874 bp from pter
Size:	36,908 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 105,249,752-105,286,646

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490 (See protein sequence)

Recommended Name: Nicotinamide phosphoribosyltransferase

Size: 491 amino acids; 55521 Da

Subcellular location: Cytoplasm (By similarity)

Caution: Was originally (PubMed:8289818) thought to be a cytokine which acts on early B-lineage

precursor cells, by enhancing the effect of IL-7 and SCF on pre-B-cell colony formation

PDB structures from and Proteopedia :

2E5B (3D)

2E5C (3D)

2E5D (3D)

2GVG (3D)

2GVJ (3D)

Secondary accessions: A4D0R0 Q3KQV0 Q8WW95

Alternative splicing: 2 isoforms: P43490-1 P43490-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005737.1

ENSEMBL proteins:

ENSP00000377240 ENSP00000377241 ENSP00000346242 ENSP00000222553

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PBEF)
	Human Recombinant Proteins from Abnova (PBEF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	8289818

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Antibodies for NAMPT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NAMPT
	R&D Systems Antibodies for NAMPT (PBEF)
	Antibodies from Abcam (PBEF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PBEF1)
	Novus Biologicals Antibodies for NAMPT

Assays for NAMPT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P43490

ProtoNet protein and cluster: P43490

UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490

Similarity: Belongs to the NAPRTase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAMPT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005746

Applied Biosystems Silencer® siRNAs for NAMPT

Sigma-Aldrich siRNA for NAMPT

Sigma-Aldrich shRNA for NAMPT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAMPT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005746
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005746
untagged cDNA clones in CMV expression vector (see all 2): NM_005746

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005746

UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490

Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield

nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting

component in the mammalian NAD biosynthesis pathway (By similarity)

Catalytic activity: Nicotinamide D-ribonucleotide + diphosphate = nicotinamide +

5-phospho-alpha-D-ribose 1-diphosphate

Enzyme Number (IUBMB): EC 2.4.2.12

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nampt):

digestive/alimentary	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	TAS	8289818
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0047280	nicotinamide phosphoribosyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for NAMPT (Your Favorite Gene powered by Ingenuity)

Nicotinate and Nicotinamide Metabolism

GeneDecks NAMPT for the pathways selected above

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UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490

Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide ribonucleotide from

5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1

Gene Network Central^TM Interacting Genes and Proteins Network for NAMPT

5/22 Interacting proteins for NAMPT (ENSP00000222553³ P43490²) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FTL	P02792²	STRING (score=.793) MINT-6538799 MINT-6538712 MINT-6538862
IFITM3	Q01628²	MINT-6538727 MINT-6538811 MINT-6538868
MT-ND1	P03886²	MINT-6538787 MINT-6538841 MINT-6538697
ADORA2A	P29274²	MINT-6538741
GGT1	P19440²	MINT-6538755

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8289818
GO:0007267	cell-cell signaling	TAS	8289818
GO:0008284	positive regulation of cell proliferation	TAS	8289818
GO:0009435	NAD biosynthetic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAMPT
10/14 Novoseek chemical compound relationships for NAMPT gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fk-866	95.07	10	14612543 (2), 18247435 (1), 18768589 (1), 17052966 (1) (see all 7)
nicotinamide mononucleotide	82.87	25	16901503 (2), 18823127 (2), 16783373 (2), 17268245 (1) (see all 7)
nad+	63.88	51	17268245 (4), 19182797 (3), 15947248 (2), 19109034 (2) (see all 16)
glucose	56.44	107	19302375 (5), 16736128 (4), 18768589 (4), 19074645 (4) (see all 43)
prpp	49.31	3	17565174 (1), 12555668 (1)
lipid	26.89	20	17429683 (3), 18246224 (2), 19142752 (2), 16735449 (2) (see all 14)
quinolinic acid	22.99	1	15837705 (1)
cholesterol	22.04	11	17054471 (2), 18627322 (2), 18940394 (1), 17697864 (1) (see all 6)
nadh	13.34	2	10218108 (1), 18486613 (1)
fatty acid	6.12	3	18448614 (1), 16720654 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAMPT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005746

Sigma-Aldrich siRNA for NAMPT

Sigma-Aldrich shRNA for NAMPT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005746

REFSEQ mRNAs for NAMPT gene:

NM_005746.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005746

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005746
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005746
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005746

Additional cDNA sequence:

AK292851.1 AK304085.1 BC072439.1 BC106046.1 CR593609.1 CR606862.1 L29050.1 U02020.1

24/35 DOTS entries (see all 35 ):

DT.100703768 DT.119356 DT.100037990 DT.100883858 DT.121066768 DT.95329224 DT.92014376 DT.100662669

DT.428653 DT.86852592 DT.121066749 DT.100883852 DT.92036344 DT.95126742 DT.91974524 DT.97802778

DT.91768071 DT.91989434 DT.95077136 DT.95251570 DT.99961287 DT.100802957 DT.100883849 DT.100883856

24/691 AceView cDNA sequences (see all 691 ):

BG678188 BQ786796 BP359047 AI343646 CB250411 N51222 AA370621 AA594385

AA369993 BX464872 AA345416 BF221904 AA487998 AA456541 BQ224320 BM504663

CD559401 NM_005746 BM987141 BX324832 BQ213335 BG370231 CB127007 AA228119

Unigene Cluster for NAMPT:

Nicotinamide phosphoribosyltransferase

Hs.489615 [show with all ESTs]

Unigene Representative Sequence: NM_005746

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000393617 ENST00000393618 ENST00000354289 ENST00000222553

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NAMPT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAMPT

¹ / ²

8 probe-sets matching NAMPT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45256_at²	U95-B	1	1.00	1.00	0.96	0.86	--	--	--	--	--
64031_at²	U95-C	1	1.00	1.00	0.95	1.26	--	--	--	--	--
33849_at²	U95-A	1	1.00	1.00	0.96	0.88	--	--	--	--	--
217739_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
217738_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
217739_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217738_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555167_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAMPT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCTTAACAA

SOURCE GeneReport for Unigene cluster: Hs.489615
UniProtKB/Swiss-Prot: NAMPT_HUMAN, P43490
Tissue specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also
present in heart, placenta, lung, and kidney tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NAMPT gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAMPT¹	--	nicotinamide phosphoribosyltransferase	94.28(n) 95.55(a)	483267 XM_540386.2 XP_540386.2
chimpanzee (Pan troglodytes)	NAMPT¹	--	nicotinamide phosphoribosyltransferase	99.66(n) 99.8(a)	463648 XM_519302.2 XP_519302.2
cow (Bos taurus)	NAMPT¹	--	nicotinamide phosphoribosyltransferase	94.77(n) 96.13(a)	520472 XM_878444.2 XP_883537.1
rat (Rattus norvegicus)	Nampt¹	--	nicotinamide phosphoribosyltransferase	89.82(n) 95.11(a)	297508 NM_177928.3 NP_808789.1
mouse (Mus musculus)	Nampt^{1, 5}	12⁵	nicotinamide phosphoribosyltransferase^{1, 5}	91.24(n)¹ 95.11(a)¹	59027¹ NM_021524.1¹ NP_067499.1¹ AF234625⁵ AI314458⁵ (see all 17)

About this table Species with no ortholog for NAMPT

ENSEMBL Gene Tree for NAMPT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/190 NCBI SNPs in NAMPT are shown (see all 190 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 85)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1319501^1,2	A,C,F,H	105712989(+)	`TGACCT/CGGGCG`	1	--	ng3¹		6		MN EU EA WA NA	667
--	rs1065322^1,2	A,C,F,H	105677534(+)	`GATGTA/CTGATT`	1	--	ut3¹		5		MN EU EA WA	602
--	rs10263784^1,2	F,H	105678700(+)	`ACAAAC/TCCCAC`	1	--	ut3¹ ese³		4		EU EA WA	418
--	rs10255622^1,2	F,H	105676790(+)	`TTACAC/TGCCCC`	1	--	ut3¹		3		EA WA	298
--	rs9034^1,2	C,F	105677292(-)	`AAAATC/TACACA`	1	--	ut3¹		3		MN NA	437
	rs2704963^1,2	A,H	105714581(+)	`TTTTTT/AATATT`	1	--	ng3¹ tfbs³		3		EU EA	298
--	rs9770242^1,2	C	105713567(+)	`TGCGAA/CACTGA`	1	--	ng3¹		0	--	--	--	--
--	rs17152845^1,2	F	105713379(-)	`GCCGCC/AGGAGG`	1	--	ng3¹		1		EA	200
--	rs2302559^1,2	A,C,F,O	105691140(+)	`CTTCTC/TGATAC`	1	S/S	syn¹		1		NA	46
	rs711438^1,2	A,C,F,H,O	105694547(+)	`TGCCTA/GATTTA`	1	--	int¹		8		MN NA EU EA WA	738

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HapMap Linkage Disequilibrium images for NAMPT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608764

10/25 Novoseek disease relationships for NAMPT gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	78.61	68	17634078 (4), 16720654 (4), 17429683 (3), 17261426 (2) (see all 38)
obesity	72.78	70	17512309 (3), 17878256 (3), 18248642 (2), 18184904 (2) (see all 33)
insulin sensitivity	65.83	20	17327330 (3), 17586594 (2), 18803942 (2), 17003355 (2) (see all 13)
inflammation	53.87	46	18248642 (4), 17634078 (3), 18184904 (2), 17763446 (2) (see all 24)
niddm	50.73	18	18691043 (2), 18246224 (1), 16401830 (1), 18686225 (1) (see all 10)
polycystic ovary syndrome	49.21	1	18848173 (1)
diabetes gestational	48.45	11	16489932 (2), 18787378 (2), 16814166 (1), 17416788 (1) (see all 7)
cardiovascular diseases	47.31	5	15968578 (1), 16311222 (1), 17970534 (1), 16391616 (1) (see all 5)
atherosclerosis	41.98	6	18663287 (1), 17378999 (1), 19302375 (1), 17931620 (1)
necrosis	39.97	26	17283255 (2), 18272217 (1), 17882804 (1), 17878891 (1) (see all 22)

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Human Genome Epidemiology Navigator: NAMPT (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/249 PubMed articles for NAMPT gene (see all 249 ):

Cloning and characterization of the cDNA encoding a novel human pre- B-cell colony-enhancing factor. (PubMed id 8289818)^{1, 2, 3, 4} Samal B.... McNiece I. (1994)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. (PubMed id 16802343)^{1, 3} Nowell M.A....Jones S.A. (2006)
Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium. (PubMed id 16021090)^{1, 3} Ognjanovic S....Bryant-Greenwood G.D. (2005)
Increased visfatin concentrations in women with gestational diabetes mellitus. (PubMed id 16489932)^{1, 3} Krzyzanowska K....Schernthaner G. (2006)
Critical role of PBEF expression in pulmonary cell inflammation and permeability. (PubMed id 18996492)^{1, 3} Liu P....Ye S.Q. (2009)
Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity. (PubMed id 18252866)^{1, 3} Luk T....Marshall J.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10135	HGNC: 30092	AceView: PBEF1	Ensembl:ENSG00000105835	euGenes: HUgn10135
ECgene: NAMPT	H-InvDB: NAMPT

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for NAMPT
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAMPT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAMPT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAMPT		Antibodies for NAMPT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAMPT		Browse small molecules at Sigma-Aldrich
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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NAMPT Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for NAMPT

Summaries
for NAMPT

Genomic Location
for NAMPT

Proteins
for NAMPT

Protein Domains/
Families
for NAMPT

Gene Function
for NAMPT

Pathways & Interactions
for NAMPT

Drugs & Compounds
for NAMPT

Transcripts
for NAMPT

Expression
for NAMPT

Orthologs
for NAMPT

Paralogs
for NAMPT

SNPs/Variants
for NAMPT

Disorders & Mutations
for NAMPT

Medical News
for NAMPT

Publications
for NAMPT

Search for NAMPT

Genome Databases showing NAMPT

Other Databases showing NAMPT

Specialized Databases showing NAMPT

Licensable Technologies
for NAMPT

Services
for NAMPT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAMPT Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor NAMPT

Summariesfor NAMPT

Genomic Locationfor NAMPT

Proteinsfor NAMPT

Protein Domains/Familiesfor NAMPT

Gene Functionfor NAMPT

Pathways & Interactionsfor NAMPT

Drugs & Compoundsfor NAMPT

Transcriptsfor NAMPT

Expression for NAMPT

Orthologsfor NAMPT

Paralogsfor NAMPT

SNPs/Variantsfor NAMPT

Disorders & Mutationsfor NAMPT

Medical Newsfor NAMPT

Publicationsfor NAMPT

Search for NAMPT

Genome Databases showing NAMPT

Other Databases showing NAMPT

Specialized Databases showing NAMPT

Licensable Technologiesfor NAMPT

Servicesfor NAMPT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAMPT

Summaries
for NAMPT

Genomic Location
for NAMPT

Proteins
for NAMPT

Protein Domains/
Families
for NAMPT

Gene Function
for NAMPT

Pathways & Interactions
for NAMPT

Drugs & Compounds
for NAMPT

Transcripts
for NAMPT

Expression
for NAMPT

Orthologs
for NAMPT

Paralogs
for NAMPT

SNPs/Variants
for NAMPT

Disorders & Mutations
for NAMPT

Medical News
for NAMPT

Publications
for NAMPT

Licensable Technologies
for NAMPT

Services
for NAMPT