Aliases for NALCN Gene
External Ids for NALCN Gene
Previous HGNC Symbols for NALCN Gene
Previous GeneCards Identifiers for NALCN Gene
NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NALCN Gene
NALCN (Sodium Leak Channel, Non Selective) is a Protein Coding gene. Diseases associated with NALCN include hypotonia-speech impairment-severe cognitive delay syndrome and hypotonia, infantile, with psychomotor retardation and characteristic facies. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include ion channel activity and sodium channel activity. An important paralog of this gene is CACNA1A.
UniProtKB/Swiss-Prot for NALCN Gene
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity).