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Aliases for NALCN Gene

Aliases for NALCN Gene

  • Sodium Leak Channel, Non-Selective 2 3 5
  • Voltage Gated Channel-Like Protein 1 3 4
  • Voltage Gated Channel Like 1 2 3
  • VGCNL1 3 4
  • CanIon 3 4
  • Sodium Leak Channel Non-Selective Protein 3
  • Four Repeat Voltage-Gated Ion Channel 3
  • BA430M15.1 3
  • CLIFAHDD 3
  • IHPRF1 3
  • IHPRF 3
  • INNFD 3

External Ids for NALCN Gene

Previous HGNC Symbols for NALCN Gene

  • VGCNL1

Previous GeneCards Identifiers for NALCN Gene

  • GC13M100505
  • GC13M101706
  • GC13M082301

Summaries for NALCN Gene

Entrez Gene Summary for NALCN Gene

  • NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NALCN Gene

NALCN (Sodium Leak Channel, Non-Selective) is a Protein Coding gene. Diseases associated with NALCN include Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay and Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ion channel activity and sodium channel activity. An important paralog of this gene is CACNA1A.

UniProtKB/Swiss-Prot for NALCN Gene

  • Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NALCN Gene

Genomics for NALCN Gene

Regulatory Elements for NALCN Gene

Enhancers for NALCN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F101397 1.1 ENCODE 8.6 +18.6 18612 2.4 JUND SIN3A FOS MAFK ITGBL1 NALCN GC13P101326 GC13P101328 GC13P101329 GC13P101330
GH13F101448 1.1 FANTOM5 Ensembl ENCODE 8.6 -36.0 -35998 9.4 CTCF MXI1 JUN SIN3A MAX RAD21 RFX5 POLR2A PATZ1 SCRT2 ITGBL1 NALCN HMGB3P7 FGF14 GC13M101537
GH13F101416 0.5 ENCODE 8.2 +0.3 343 0.9 ZIC2 E2F1 ZFHX2 ZBTB48 PATZ1 SCRT2 PRDM10 ZNF600 ZBTB20 EZH2 NALCN GC13P101326 GC13P101328 GC13P101329 GC13P101330
GH13F101520 1.3 Ensembl ENCODE 6.3 -104.1 -104059 1.7 JUND JUN MAFK RNU1-24P FGF14 HMGB3P7 NALCN GC13M101537 ITGBL1
GH13F101407 0.4 Ensembl 6.2 +9.5 9505 0.2 NALCN GC13P101326 GC13P101328 GC13P101329 GC13P101330
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NALCN on UCSC Golden Path with GeneCards custom track

Promoters for NALCN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000519802 1004 1600 ZSCAN5A ZIC2 E2F1 ZFHX2 ZBTB48 PATZ1 SCRT2 PRDM10 ZNF600 ZBTB20

Genomic Location for NALCN Gene

Chromosome:
13
Start:
101,053,776 bp from pter
End:
101,417,205 bp from pter
Size:
363,430 bases
Orientation:
Minus strand

Genomic View for NALCN Gene

Genes around NALCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NALCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NALCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NALCN Gene

Proteins for NALCN Gene

  • Protein details for NALCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF0-NALCN_HUMAN
    Recommended name:
    Sodium leak channel non-selective protein
    Protein Accession:
    Q8IZF0
    Secondary Accessions:
    • Q6P2S6
    • Q6ZMI7
    • Q8IZZ1
    • Q8TAH1

    Protein attributes for NALCN Gene

    Size:
    1738 amino acids
    Molecular mass:
    200331 Da
    Quaternary structure:
    • Interacts with UNC80; required for the NALCN activation/inhibition by GPCRs in neurons. Found in a complex with NALCN, UNC79 and UNC80; UNC80 bridges NALCN to UNC79. Interacts with CHRM3.
    SequenceCaution:
    • Sequence=BAD18738.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NALCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NALCN Gene

Post-translational modifications for NALCN Gene

No data available for DME Specific Peptides for NALCN Gene

Domains & Families for NALCN Gene

Gene Families for NALCN Gene

Protein Domains for NALCN Gene

Suggested Antigen Peptide Sequences for NALCN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZF0

UniProtKB/Swiss-Prot:

NALCN_HUMAN :
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor. S4 transmembrane segments lack some of the charged residues (K and R) found at every third position in the S4s of the NaV, CaV, and KV channels. Pore-forming loops (P loops) between S5 and S6 of each domain form an EEKE sodium- ion selectivity filter a mixture between the EEEE found in the CaVs and the DEKA of NaVs.
  • Belongs to the cation-nonselective channel family.
Domain:
  • Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor. S4 transmembrane segments lack some of the charged residues (K and R) found at every third position in the S4s of the NaV, CaV, and KV channels. Pore-forming loops (P loops) between S5 and S6 of each domain form an EEKE sodium- ion selectivity filter a mixture between the EEEE found in the CaVs and the DEKA of NaVs.
Family:
  • Belongs to the cation-nonselective channel family.
genes like me logo Genes that share domains with NALCN: view

Function for NALCN Gene

Molecular function for NALCN Gene

UniProtKB/Swiss-Prot Function:
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity).

Gene Ontology (GO) - Molecular Function for NALCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005261 cation channel activity ISS,IBA --
GO:0005272 sodium channel activity TAS --
GO:0005515 protein binding IPI 19575010
GO:0022840 leak channel activity ISS --
genes like me logo Genes that share ontologies with NALCN: view
genes like me logo Genes that share phenotypes with NALCN: view

Human Phenotype Ontology for NALCN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NALCN Gene

MGI Knock Outs for NALCN:

Animal Model Products

  • Taconic Biosciences Mouse Models for NALCN

miRNA for NALCN Gene

miRTarBase miRNAs that target NALCN

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NALCN Gene

Localization for NALCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NALCN Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NALCN Gene COMPARTMENTS Subcellular localization image for NALCN gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for NALCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NALCN: view

Pathways & Interactions for NALCN Gene

genes like me logo Genes that share pathways with NALCN: view

Pathways by source for NALCN Gene

Gene Ontology (GO) - Biological Process for NALCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006816 calcium ion transport IBA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with NALCN: view

No data available for SIGNOR curated interactions for NALCN Gene

Drugs & Compounds for NALCN Gene

(6) Drugs for NALCN Gene - From: PharmGKB, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Verapamil Approved Pharma Channel blocker, blocker 125
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1518
Cd<sup>2+</sup> Pharma Channel blocker 0
Co<sup>2+</sup> Pharma Channel blocker 0
Gd<sup>3+</sup> Pharma Channel blocker 0

(1) Additional Compounds for NALCN Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with NALCN: view

Transcripts for NALCN Gene

Unigene Clusters for NALCN Gene

Sodium leak channel, non-selective:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NALCN Gene

No ASD Table

Relevant External Links for NALCN Gene

GeneLoc Exon Structure for
NALCN
ECgene alternative splicing isoforms for
NALCN

Expression for NALCN Gene

mRNA expression in normal human tissues for NALCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NALCN Gene

This gene is overexpressed in Bone (20.7), Bone marrow mesenchymal stem cell (15.2), Heart (14.1), Platelet (10.7), and Fetal gut (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NALCN Gene



Protein tissue co-expression partners for NALCN Gene

NURSA nuclear receptor signaling pathways regulating expression of NALCN Gene:

NALCN

SOURCE GeneReport for Unigene cluster for NALCN Gene:

Hs.525146
genes like me logo Genes that share expression patterns with NALCN: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NALCN Gene

Orthologs for NALCN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NALCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NALCN 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia NALCN 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NALCN 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NALCN 34 35
  • 91.6 (n)
cow
(Bos Taurus)
Mammalia NALCN 34 35
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Nalcn 34 16 35
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Nalcn 34
  • 89.48 (n)
chicken
(Gallus gallus)
Aves NALCN 34 35
  • 83.79 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 96 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
-- 35
  • 13 (a)
OneToMany
-- 35
  • 11 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nalcn 34
  • 80.4 (n)
zebrafish
(Danio rerio)
Actinopterygii nalcn 34 35
  • 77.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta na 34 35
  • 58.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003921 34
  • 57.97 (n)
worm
(Caenorhabditis elegans)
Secernentea nca-2 34
  • 52.91 (n)
F17C8.6 35
  • 45 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCH1 35 37
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
Species where no ortholog for NALCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NALCN Gene

ENSEMBL:
Gene Tree for NALCN (if available)
TreeFam:
Gene Tree for NALCN (if available)

Paralogs for NALCN Gene

genes like me logo Genes that share paralogs with NALCN: view

Variants for NALCN Gene

Sequence variations from dbSNP and Humsavar for NALCN Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs587777068 Hypotonia, infantile, with psychomotor retardation and characteristic facies 1 (IHPRF1) [MIM:615419], Pathogenic 101,081,552(+) CCACC(A/C)ATACA reference, missense
rs786203984 Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD) [MIM:616266], Pathogenic 101,376,814(-) AGAAC(A/C)AATAT reference, missense
rs786203985 Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD) [MIM:616266], Pathogenic 101,292,228(-) GCTTG(G/T)GAAGG reference, missense
rs786203986 Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD) [MIM:616266], Pathogenic 101,176,371(-) AGATC(C/T)TCCTG reference, missense
rs786203987 Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD) [MIM:616266], Pathogenic 101,229,493(-) GAGTT(C/T)GGTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NALCN Gene

Variant ID Type Subtype PubMed ID
dgv121e215 CNV deletion 23714750
dgv3364n54 CNV gain 21841781
dgv3365n54 CNV loss 21841781
dgv3366n54 CNV gain+loss 21841781
dgv3367n54 CNV loss 21841781
dgv3368n54 CNV gain 21841781
dgv578e212 CNV loss 25503493
esv1011072 CNV deletion 20482838
esv1093475 CNV deletion 17803354
esv1761857 CNV deletion 17803354
esv2282833 CNV deletion 18987734
esv23881 CNV gain+loss 19812545
esv2424310 CNV deletion 19546169
esv2524562 CNV loss 19546169
esv2659720 CNV deletion 23128226
esv2671073 CNV deletion 23128226
esv2747897 CNV deletion 23290073
esv2747898 CNV deletion 23290073
esv274989 CNV gain+loss 21479260
esv3247718 CNV deletion 24192839
esv3303305 CNV mobile element insertion 20981092
esv3337 CNV loss 18987735
esv3350657 CNV duplication 20981092
esv3399391 CNV insertion 20981092
esv3550981 CNV deletion 23714750
esv3550982 CNV deletion 23714750
esv3633358 CNV loss 21293372
esv3633359 CNV loss 21293372
esv3633360 CNV loss 21293372
esv3633362 CNV loss 21293372
esv7952 CNV loss 19470904
esv987666 CNV deletion 20482838
nsv1069098 CNV deletion 25765185
nsv1113597 CNV deletion 24896259
nsv1119436 CNV insertion 24896259
nsv1125577 CNV tandem duplication 24896259
nsv1129550 CNV tandem duplication 24896259
nsv1149 CNV deletion 18451855
nsv1150 CNV insertion 18451855
nsv474538 CNV novel sequence insertion 20440878
nsv511517 CNV loss 21212237
nsv512333 CNV loss 21212237
nsv514687 CNV gain 21397061
nsv514688 CNV loss 21397061
nsv516078 CNV loss 19592680
nsv519642 CNV loss 19592680
nsv528744 CNV loss 19592680
nsv562960 CNV gain 21841781
nsv562967 CNV gain+loss 21841781
nsv562973 CNV loss 21841781
nsv562975 CNV loss 21841781
nsv64877 CNV deletion 16902084
nsv820338 CNV deletion 20802225
nsv826769 CNV loss 20364138
nsv826770 CNV loss 20364138
nsv826771 CNV gain+loss 20364138
nsv832699 CNV gain 17160897
nsv832700 CNV gain 17160897
nsv957455 CNV deletion 24416366
nsv958067 CNV deletion 24416366
nsv977275 CNV duplication 23825009

Variation tolerance for NALCN Gene

Residual Variation Intolerance Score: 0.843% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NALCN Gene

Human Gene Mutation Database (HGMD)
NALCN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NALCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NALCN Gene

Disorders for NALCN Gene

MalaCards: The human disease database

(10) MalaCards diseases for NALCN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NALCN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NALCN_HUMAN
  • Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD) [MIM:616266]: A disease characterized by congenital contractures of the limbs and face, resulting in characteristic facial features, abnormal tone, most commonly manifested as hypotonia, and variable degrees of developmental delay. {ECO:0000269 PubMed:25683120}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypotonia, infantile, with psychomotor retardation and characteristic facies 1 (IHPRF1) [MIM:615419]: A neurodegenerative disease characterized by variable degrees of hypotonia, speech impairment, intellectual disability, pyramidal signs, subtle facial dysmorphism, and chronic constipation. Some patients manifest neuroaxonal dystrophy, optic atrophy, unmyelinated axons and spheroid bodies in tissue biopsies. {ECO:0000269 PubMed:23749988, ECO:0000269 PubMed:24075186}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NALCN

Genetic Association Database (GAD)
NALCN
Human Genome Epidemiology (HuGE) Navigator
NALCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NALCN
genes like me logo Genes that share disorders with NALCN: view

No data available for Genatlas for NALCN Gene

Publications for NALCN Gene

  1. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. (PMID: 17448995) Lu B. … Ren D. (Cell 2007) 2 3 4 64
  2. De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. (PMID: 25683120) Chong J.X. … Bamshad M.J. (Am. J. Hum. Genet. 2015) 3 4 64
  3. Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism. (PMID: 23749988) KAProA9lu A.8. … Tolun A. (J. Med. Genet. 2013) 3 4 64
  4. Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay. (PMID: 24075186) Al-Sayed M.D. … Kaya N. (Am. J. Hum. Genet. 2013) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for NALCN Gene

Sources for NALCN Gene

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