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Aliases & Descriptions for NALCN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CanIon 1, 2, 3 | | FLJ23913 2 | | FLJ44659 2 | | FLJ44764 2 | | MGC74524 2 | | OTTHUMP00000018654 2 | | OTTHUMP00000018655 2 | | OTTHUMP00000018656 2 | | OTTHUMP00000040730 2 | | VGCNL1 2, 3 | | bA430M15.1 1, 2 |
| | | Descriptions |
|---|
| Voltage gated channel-like protein 1 3 | | four repeat voltage-gated ion channel 2 | | sodium leak channel, non-selective 2 | | voltage gated channel like 1 1, 2 |
|
| | Search outside databases for aliases for NALCN gene |
Summaries for NALCN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NALCN: NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM] UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0Function: Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity) |
Genomic Location for NALCN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q32.3 Ensembl cytogenetic band: 13q33.1 HGNC cytogenetic band: 13q32.3NALCN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M100505:
(about GC identifiers)
Start:
|
100,504,131 bp from pter |
End:
|
100,866,814 bp from pter |
Size:
|
362,684 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000013.9 NT_009952.14
| Proteins for NALCN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0 (See
protein sequence)Recommended Name: Sodium leak channel non-selective protein Size: 1738 amino acids; 200331 Da
Subunit: Interacts with UNC79/KIAA1409 and UNC80 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6P2S6 Q6ZMI7 Q8IZZ1 Q8TAH1Alternative splicing: 3 isoforms: Q8IZF0-1 Q8IZF0-2 Q8IZF0-3 Post-translational modifications:
Phosphorylated on tyrosine residues (By similarity)1
REFSEQ proteins: NP_443099.1
ENSEMBL proteins: ENSP00000365367 ENSP00000365373 ENSP00000251127
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for NALCN: Assays for NALCN: | Protein
Domains/ Families for NALCN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IZF0
ProtoNet protein and cluster: Q8IZF0 UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the cation-nonselective channel family | Gene Function for NALCN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052867
Applied Biosystems Silencer® siRNAs for NALCN
Sigma-Aldrich siRNA and siRNA Panels for NALCN  Sigma-Aldrich shRNA Panels and shRNA for NALCN  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_052867                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_052867                                  untagged cDNA clones in CMV expression vector (see all 4): NM_052867 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_052867
UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0Function: Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity)7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Nalcn):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005272 | sodium channel activity |
IEA | -- | | GO:0031402 | sodium ion binding |
IEA | -- | About this table | Pathways & Interactions for NALCN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006814 | sodium ion transport |
IEA | -- | About this table
|
Drugs & Compounds for NALCN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NALCN
|
Transcripts for NALCN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052867
Sigma-Aldrich siRNA and siRNA Panels for NALCN  Sigma-Aldrich shRNA Panels and shRNA for NALCN  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_052867 REFSEQ mRNAs for NALCN gene: NM_052867.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_052867               OriGene GFP tagged cDNA clone in CMV expression vector: NM_052867                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_052867                                  untagged cDNA clones in CMV expression vector (see all 4): NM_052867  Additional cDNA sequence: AF339780.1 AK002089.1 AK055506.1 AK094390.1 AK094669.1 AK126621.1 AK126718.1 AK172752.1 AY141972.1 BC012128.1 BC028390.1 BC064343.1 6 DOTS entries: DT.109049 DT.100009034 DT.91697284 DT.91655058 DT.40115258 DT.86856304 24/72 AceView cDNA sequences (see all 72
):AW149508 BU948062 AI168806 BC064343 AI811060 CA775297 AU145670 AY141972 BM556576 NM_052867 AK002089 BX508225 BC012128 BU069355 BE220114 AU138314 AK126621 AK126718 AW205016 BE671149 AU119288 N40916 BE327303 AK094669 Unigene Cluster for NALCN: Sodium leak channel, non-selective Hs.525146 [show with all ESTs]Unigene Representative Sequence: NM_052867
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000376196
ENST00000376200
ENST00000251127
|
Expression for NALCN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NALCN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NALCN
1 / 2 6 probe-sets matching NALCN gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGCTCAGGAG
SOURCE GeneReport for Unigene cluster: Hs.525146
|
Orthologs for NALCN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NALCN gene from 5/16 species (see all 16
)
About this table Species with no ortholog for NALCN
ENSEMBL Gene Tree for NALCN | Paralogs for NALCN(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for NALCN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NALCN (up to first 250kb)
|
Disorders & Mutations for NALCN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611549
Human Genome Epidemiology Navigator: NALCN (1 document)
|
Medical News for NALCN(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NALCN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for NALCN gene (see all 12
): |
Search for NALCN
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NALCN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NALCN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NALCN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NALCN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NALCN:

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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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