Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NALCN Gene

protein-coding GIFtS: 51
GCID: GC13M101706

sodium leak channel, non-selective

(Previous name: voltage gated channel like 1 )
(Previous symbol: VGCNL1)

Explore 5 diseases affiliated with
NALCN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sodium Leak Channel, Non-Selective¹ ²		Voltage Gated Channel Like 1¹ ²
CanIon¹ ² ³		Voltage Gated Channel-Like Protein 1² ³
VGCNL1¹ ² ³		Four Repeat Voltage-Gated Ion Channel²
BA430M15.1¹		Sodium Leak Channel Non-Selective Protein²

External Ids:	HGNC: 19082¹	Entrez Gene: 259232²	Ensembl: ENSG00000102452⁷	OMIM: 611549⁵	UniProtKB: Q8IZF0³

Export aliases for NALCN gene to outside databases

Previous GC identifers: GC13M100505 GC13M082301

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NALCN:

NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is

responsible for the neuronal background sodium leak conductance (Lu et al., 2007 (PubMed 17448995)).(supplied by OMIM,

Mar 2008)

UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0

Function: Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions.

Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either

by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_009952.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NALCN gene promoter:
p53 AML1a MyoD FOXL1 E47 S8 POU2F1 POU2F1a SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NALCN promoter sequence

Search SABiosciences Chromatin IP Primers for NALCN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NALCN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3 Ensembl cytogenetic band: 13q33.1 HGNC cytogenetic band: 13q32.3

NALCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NALCN gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M101706: view genomic region (about GC identifiers)

Start:	101,706,130 bp from pter	End:	102,068,843 bp from pter
Size:	362,714 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0 (See protein sequence)

Recommended Name: Sodium leak channel non-selective protein

Size: 1738 amino acids; 200331 Da

Subunit: Interacts with UNC79 and UNC80 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=BAD18738.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q6P2S6 Q6ZMI7 Q8IZZ1 Q8TAH1

Alternative splicing: 3 isoforms: Q8IZF0-1 Q8IZF0-2 Q8IZF0-3

Explore the universe of human proteins at neXtProt for NALCN: NX_Q8IZF0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IZF0

NALCN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443099.1

ENSEMBL proteins:

ENSP00000251127 ENSP00000365367 ENSP00000365373

Reactome Protein details: Q8IZF0
Human Recombinant Protein Products for NALCN:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for NALCN
	GenScript Custom Purified and Recombinant Proteins Services for NALCN
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NALCN

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

NALCN for ontologies About GeneDecksing

NALCN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NALCN
	GenScript Custom Superior Antibodies Services for NALCN
	Novus Biologicals NALCN Antibodies
	Abcam antibodies for NALCN
	Uscn Antibodies for NALCN
	Search ThermoFisher Antibodies for NALCN

Assay Products for NALCN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NALCN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NALCN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NALCN for domains About GeneDecksing

1 InterPro domain/family:

IPR005821 Ion_trans_dom

Graphical View of Domain Structure for InterPro Entry Q8IZF0

ProtoNet protein and cluster: Q8IZF0

UniProtKB/Swiss-Prot: NALCN_HUMAN, Q8IZF0

Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one

positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized

by a series of positively charged amino acids at every third position

Similarity: Belongs to the cation-nonselective channel family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NALCN_HUMAN, Q8IZF0

Function: Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions.

Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either

by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By

similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005272	sodium channel activity	IEA	--

NALCN for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for NALCN:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Upregulation of Wnt/beta-caten

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nalcn):

behavior/neurological	embryogenesis	homeostasis/metabolism	mortality/aging	nervous system
no phenotypic analysis	respiratory system

NALCN for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NALCN: Nalcn^tm1Lex Nalcn^tm1.1Dren

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NALCN

miRNA Products:		OriGene 3'-UTR Clone: NALCN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NALCN
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate NALCN:
		hsa-miR-587 hsa-miR-628-5p hsa-miR-20b*
		SwitchGear 3'UTR luciferase reporter plasmid: NALCN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NALCN (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NALCN
		Sirion Biotech Custom design and validation of potent shRNA sequences against NALCN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NALCN
			Sirion Biotech Customized adenovirus for overexpression of NALCN Sirion Biotech Customized adenovirus for potent knockdown of NALCN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NALCN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NALCN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NALCN (NM_052867)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NALCN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NALCN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NALCN
		Search LifeMap BioReagents cell lines for NALCN
		Sirion Biotech Customized stable knockdown cell line services for NALCN Sirion Biotech Customized inducible knockdown cell line services for NALCN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NALCN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Stimuli-sensing channels

0.49

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for NALCN

	Transmembrane transport of small molecules
	Stimuli-sensing channels
	Ion channel transport

NALCN for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NALCN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for NALCN (Q8IZF0^{2, 3} ENSP00000251127⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHRM3	P20309²^,³, ENSP00000255380⁴	MINT-7255462 MINT-7255449 MINT-7255436 I2D: score=1 STRING: ENSP00000255380
ATG4B	Q9Y4P1³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NALCN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NALCN

2 HMDB Compounds for NALCN About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Sodium	Sodium (see all 2)	7440-23-5	--

1 PharmGKB related drug/compound annotation for NALCN gene About this table

Drug/compound	PharmGKB Annotation
methotrexate	CA

Search CenterWatch for drugs/clinical trials and news about NALCN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NALCN gene:

NM_052867.2

Unigene Cluster for NALCN:

Sodium leak channel, non-selective

Hs.525146 [show with all ESTs]

Unigene Representative Sequence: NM_052867

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000251127(uc001vox.1) ENST00000467264 ENST00000497170(uc001voy.3)

ENST00000470333(uc001vpa.2) ENST00000376196(uc001voz.2) ENST00000376200

miRNA Products:		OriGene 3'-UTR Clone: NALCN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NALCN
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate NALCN:
		hsa-miR-587 hsa-miR-628-5p hsa-miR-20b*
		SwitchGear 3'UTR luciferase reporter plasmid: NALCN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NALCN (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NALCN
		Sirion Biotech Custom design and validation of potent shRNA sequences against NALCN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NALCN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NALCN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NALCN (NM_052867)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NALCN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NALCN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NALCN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NALCN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NALCN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NALCN

Additional cDNA sequence:

AF339780.1 AK002089.1 AK055506.1 AK094390.1 AK094669.1 AK126621.1 AK126718.1 AK172752.1

AY141972.1 BC012128.1 BC028390.1 BC064343.1

6 DOTS entries:

DT.109049 DT.100009034 DT.91697284 DT.91655058 DT.40115258 DT.86856304

24/72 AceView cDNA sequences (see all 72):

NM_052867 AK002089 AY141972 BX508225 BC064343 AI811060 BU948062 BU069355

CA775297 BE220114 BM556576 AU145670 AI168806 AU138314 AW149508 BC012128

AU119288 BE671581 BE220480 N63403 AK172752 AK055506 BC028390 BQ773160

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NALCN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTCAGGAG

About this image

NALCN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NALCN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NALCN

SOURCE GeneReport for Unigene cluster: Hs.525146

SABiosciences Custom PCR Arrays for NALCN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NALCN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NALCN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NALCN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NALCN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NALCN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NALCN gene from 5/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NALCN¹	sodium leak channel, non-selective	83.79(n) 96.89(a)		418770 XM_416967.2 XP_416967.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	96(a) 95(a)	1 ↔ many 1 ↔ many	3(100019267-100209909) 3(99935606-99957580)
zebrafish (Danio rerio)	Actinopterygii	nalcn¹	sodium leak channel, non-selective	77.56(n) 91.32(a)		548345 NM_001017549.2 NP_001017549.2
fruit fly (Drosophila melanogaster)	Insecta	na¹	narrow abdomen	59.06(n) 59.12(a)		45338 NM_001103511.2 NP_001096981.1
worm (Caenorhabditis elegans)	Secernentea	nca-2¹	Protein NCA-2	53.4(n) 51.37(a)		175674 NM_065653.3 NP_498054.2

ENSEMBL Gene Tree for NALCN (if available)
TreeFam Gene Tree for NALCN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145910377^1,2	C,F	other	102047576(+)	`TCTGCC/TGTGTA`	2	T	syn¹		1		NA	4550
rs191846174^1,2		--	101705707(+)	`AAATAC/TATTGG`	2	--	int¹ ds500¹		0	--	--	--	--
rs34937692^1,2	C	--	101705764(+)	`CTGAA-/CATCATCA`	2	--	ds500¹ int¹		0	--	--	--	--
rs75174320^1,2	C	--	101705872(+)	`TAGTAC/TAGACC`	2	--	ds500¹ int¹		1		WA	118
rs9585606^1,2	C,F,H	--	101705908(+)	`TTCTGT/CTCATT`	2	--	ds500¹ int¹		7		NS EA WA NA	776
rs115477064^1,2	F	--	101706075(+)	`GCTACC/TGAGTG`	2	--	int¹ ds500¹		1		WA	118
rs7989932^1,2	C,F,A,H	--	101706123(+)	`TCAGAG/ATAAAT`	2	--	int¹ ds500¹		18		NA NS EA	1666
rs151119409^1,2		--	101706172(+)	`CAAAAA/GGTAAA`	2	--	int¹ ut3¹		0	--	--	--	--
rs8922^1,2	C,F,O,A,H	--	101706193(-)	`TGATTT/GGATGT`	2	--	int¹ ut3¹		25		MN NA NS EA WA	2756
rs3794411^1,2	C,F	--	101706222(+)	`ACATGA/CCTGGT`	2	--	ut3¹ int¹		5		EA NA	1762

HapMap Linkage Disequilibrium report for NALCN (101706130 - 101956130 bp, first 250kb of NALCN)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for NALCN
11 CNVs: 49166 43874 61349 87001 87002 76473 101837 23454 76472 5722 66531
5 Indels: 25110 87000 87003 41981 76471

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NALCN

DNA2.0 Custom Variant and Variant Library Synthesis for NALCN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NALCN for disorders           About GeneDecksing

OMIM gene information: 611549    OMIM disorders: --

5 diseases for NALCN:    About MalaCards

neuronitis bipolar disorder pharyngitis schizophrenia

pancreatitis

Human Genome Epidemiology (HuGE) Navigator: NALCN (4 documents)

Export disorders for NALCN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NALCN gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with NALCN)

Utopia: connect your pdf to the dynamic
world of online information

The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. (PubMed id 17448995)^{1, 2, 3} Lu B.... Ren D. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)^{1, 2} Chumakov I.... Cohen D. (2002)
Genome-wide association study of neurocognitive impair ment and dementia in HIV-infected adults. (PubMed id 22628157)¹ Levine A.J....Freimer N. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312)¹ Wang K.S....Aragam N. (2010)
Lack of association of NALCN genetic variants with sc hizophrenia. (PubMed id 20674038)¹ Souza R.P....Wong A.H. (2010)
The NALCN ion channel is activated by M3 muscarinic r eceptors in a pancreatic beta-cell line. (PubMed id 19575010)¹ Swayne L.A....Monteil A. (2009)
UNC80 functions as a scaffold for Src kinases in NALC N channel function. (PubMed id 19535918)¹ Wang H. and Ren D. (2009)
Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)¹ Ollila H.M....Paunio T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 259232	HGNC: 19082	AceView: VGCNL1	Ensembl:ENSG00000102452	euGenes: HUgn259232
ECgene: NALCN	H-InvDB: NALCN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NALCN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NALCN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NALCN gene:
Search GeneIP for patents involving NALCN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NALCN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NALCN
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for NALCN
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NALCN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NALCN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NALCN		OriGene Custom Protein Services for NALCN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NALCN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NALCN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NALCN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NALCN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NALCN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NALCN

	GenScript Custom Purified and Recombinant Proteins Services for NALCN		GenScript cDNA clones with any tag delivered in your preferred vector for NALCN
	GenScript Custom Assay Services for NALCN		GenScript Custom Superior Antibodies Services for NALCN
	GenScript Custom overexpressing Cell Line Services for NALCN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NALCN promoter
	Search Chromatin IP Primers for NALCN
	RT² qPCR Primer Assay in human, mouse, rat NALCN
	Search GNC Networks for NALCN
	SABiosciences Custom PCR Arrays for NALCN

Search Tocris compounds for NALCN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NALCN antibodies

	Antibodies for NALCN
	See all of Abcam's Antibodies, Kits and Proteins for NALCN
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NALCN Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NALCN

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NALCN

	SwitchGear 3'UTR luciferase reporter plasmids for NALCN
	SwitchGear Promoter luciferase reporter plasmids for NALCN

Search ThermoFisher Antibodies for NALCN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NALCN

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NALCN

Sirion Biotech Customized:

	stable knockdown cell line services for NALCN
	inducible knockdown cell line services for NALCN
	design and validation of potent shRNA sequences against NALCN
	adenovirus for potent knockdown of NALCN
	adenovirus for overexpression of NALCN
	stable overexpressing cell line services
	inducible overexpressing cell line services

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NALCN gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

NALCN Gene

sodium leak channel, non-selective

Aliases
for NALCN gene

Summaries
for NALCN gene

Genomic Views
for NALCN gene

Proteins
for NALCN gene

Protein Domains /
Families
for NALCN gene

Function
for NALCN gene

Pathways & Interactions
for NALCN gene

Drugs & Compounds
for NALCN gene

Transcripts
for NALCN gene

Expression
for NALCN gene

Orthologs
for NALCN gene

Paralogs
for NALCN gene

Genomic Variants
for NALCN gene

Disorders / Diseases
for NALCN gene

Publications
for NALCN gene

External Searches for NALCN gene

Genome Databases showing NALCN gene

Other Databases showing NALCN gene

Specialized Databases showing NALCN gene

Intellectual Property
for NALCN gene

Products
for NALCN gene

View Random Gene

Advanced Search

Export list of displayed genes

NALCN Gene

sodium leak channel, non-selective

Aliasesfor NALCN gene

Summariesfor NALCN gene

Genomic Viewsfor NALCN gene

Proteinsfor NALCN gene

Protein Domains /Familiesfor NALCN gene

Functionfor NALCN gene

Pathways & Interactionsfor NALCN gene

Drugs & Compoundsfor NALCN gene

Transcriptsfor NALCN gene

Expression for NALCN gene

Orthologsfor NALCN gene

Paralogsfor NALCN gene

Genomic Variantsfor NALCN gene

Disorders / Diseasesfor NALCN gene

Publicationsfor NALCN gene

External Searches for NALCN gene

Genome Databases showing NALCN gene

Other Databases showing NALCN gene

Specialized Databases showing NALCN gene

Intellectual Propertyfor NALCN gene

Productsfor NALCN gene

View Random Gene

Aliases
for NALCN gene

Summaries
for NALCN gene

Genomic Views
for NALCN gene

Proteins
for NALCN gene

Protein Domains /
Families
for NALCN gene

Function
for NALCN gene

Pathways & Interactions
for NALCN gene

Drugs & Compounds
for NALCN gene

Transcripts
for NALCN gene

Expression
for NALCN gene

Orthologs
for NALCN gene

Paralogs
for NALCN gene

Genomic Variants
for NALCN gene

Disorders / Diseases
for NALCN gene

Publications
for NALCN gene

Intellectual Property
for NALCN gene

Products
for NALCN gene