Aliases for NALCN Gene
External Ids for NALCN Gene
Previous HGNC Symbols for NALCN Gene
Previous GeneCards Identifiers for NALCN Gene
NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NALCN Gene
NALCN (Sodium Leak Channel, Non Selective) is a Protein Coding gene. Diseases associated with NALCN include neuroaxonal neurodegeneration, infantile, with facial dysmophism and hypotonia-speech impairment-severe cognitive delay syndrome. Among its related pathways are Ion channel transport and Ion channel transport. GO annotations related to this gene include voltage-gated ion channel activity and sodium channel activity. An important paralog of this gene is CACNA1A.
UniProtKB/Swiss-Prot for NALCN Gene
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity).