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Aliases & Descriptions for NAIP
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BIRC1 2 , 3 , 5 FLJ18088 2 FLJ42520 2 FLJ58811 2 NLRB1 1 , 2 OTTHUMP00000125255 2 psiNAIP 2
Descriptions NLR family, BIR domain containing 1 2 NLR family, apoptosis inhibitory protein 2 Neuronal apoptosis inhibitory protein 2 , 3 baculoviral IAP repeat-containing 1 1 , 2 nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1 2 psi neuronal apoptosis inhibitory protein 2
Search outside databases for aliases for NAIP genePrevious GC identifer: GC05M070401
Summaries for NAIP (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for NAIP : This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated regioncontains at least four genes and repetitive elements which make it prone to rearrangements anddeletions. The repetitiveness and complexity of the sequence have also caused difficulty indetermining the organization of this genomic region. This copy of the gene is full length;additional copies with truncations and internal deletions are also present in this region ofchromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused bymutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions ofhomology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosisinduced by various signals. Alternatively spliced transcript variants encoding distinct isoformshave been found for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 Function : Prevents motor-neuron apoptosis induced by a variety of signals
Gene Wiki entry for NAIP
Genomic Location for NAIP
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5q13.1 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13.1 NAIP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M070301:
(about GC identifiers )
Start:
70,300,066 bp from pter
End:
70,356,697 bp from pter
Size:
56,632 bases
Orientation:
minus strand
1 alternative location : Chr 5+,c5_H2 69,358,495-69,415,104
RefSeq DNA sequence: NC_000005.8 NT_006713.14 NT_113801.1 Proteins for NAIP
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 (See
protein sequence )Recommended Name: Baculoviral IAP repeat-containing protein 1 Size : 1403 amino acids; 159582 Da
Sequence caution : Sequence=AAC62261.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia : 2VM5 (3D)
 
Secondary accessions : O75857 Q13730 Q59GI6 Q99796
REFSEQ proteins (2 alternative transcripts):
NP_004527.2 NP_075043.1 ENSEMBL proteins: ENSP00000194097 ENSP00000311089 ENSP00000370076 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
About this table Antibodies for NAIP: Assays for NAIP:
Protein
Domains/ Families for NAIP(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q13075 ProtoNet protein and cluster: Q13075
1 Blocks protein family : IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR) UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 Similarity : Contains 3 BIR repeatsSimilarity : Contains 1 NACHT domain
Gene Function for NAIP
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_022892 Applied Biosystems Silencer ® siRNAs for NAIP Sigma-Aldrich siRNA for NAIP Sigma-Aldrich shRNA for NAIP Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004536                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004536                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004536  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004536 UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 Function : Prevents motor-neuron apoptosis induced by a variety of signals
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Naip1) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
IEA -- GO:0017111 nucleoside-triphosphatase activity
IEA --
About this table
Pathways & Interactions for NAIP
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for NAIP (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for NAIP 5/8 Interacting proteins for NAIP (ENSP00000194097 3 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for NAIP (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for NAIP 2 Novoseek chemical compound relationships for NAIP gene
About this table
Transcripts for NAIP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_022892 Sigma-Aldrich siRNA for NAIP Sigma-Aldrich shRNA for NAIP Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004536 NM_022892
REFSEQ mRNAs for NAIP gene (2 alternative transcripts): NM_004536.2 NM_022892.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004536 NM_022892
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004536                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004536                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004536  
Additional cDNA sequence: AB048534.1 AB209123.1 AK124511.1 AK295115.1 AK309627.1 BC136273.1 BC143761.1 U19251.1
12 DOTS entries : DT.115455 DT.91919714 DT.99927684 DT.65287141 DT.65286481 DT.95197494 DT.100670959 DT.120845050 DT.120845093 DT.215933 DT.456071 DT.99985602
8 AceView cDNA sequences :BF589758 NM_004536 AW137096 AA770519 AI204610 AI539635 BE672529 AA759208
highest scoring ESTs for NAIP :U19251 AA236415 AA401859 AA482660 AA534960 AA621150 AA662221 AA662615 AA759208 AA770519
Unigene Cluster for NAIP: NLR family, apoptosis inhibitory protein Hs.654500 [show with all ESTs ] Unigene Representative Sequence: NM_004536 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000194097
ENST00000348972
ENST00000380700
Expression for NAIP
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NAIP expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NAIP 1 / 2 / 3
7 probe-sets matching NAIP gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGCCTCAAGTSOURCE GeneReport for Unigene cluster: Hs.654500 UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 Tissue specificity : Expressed in motor neurons, but not in sensory neurons. Found in liver andplacenta, and to a lesser extent in spinal cord
Orthologs for NAIP
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NAIP gene from 4 species
About this table Species with no ortholog for NAIP ENSEMBL Gene Tree for NAIP Paralogs for NAIP (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for NAIP gene LOC728519 2 NLRC4 2
SNPs/Variants for NAIP (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NAIP (up to first 250kb)
Disorders & Mutations for NAIP
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600355 UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
Mutated or deleted forms of NAIP have been found in individuals with severe spinalmuscular atrophy (SMA) leading to the hypothesis that mutations in the NAIP locus may contributeto the SMA phenotype
10/18 Novoseek disease relationships for NAIP gene (see all 18
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
muscular atrophy spinal
96.31
60
9363657 (2), 9341874 (2), 17250498 (2), 9073029 (2) (see all 48 )
sma ii
93.86
8
8595417 (1), 18842367 (1), 9341874 (1), 7581364 (1) (see all 7 )
sma iii
92.60
6
8595417 (1), 8730281 (1), 15305106 (1), 10686495 (1) (see all 5 )
werdnig-hoffmann disease
82.08
1
12547647 (1)
paralysis progressive
71.20
1
12547647 (1)
neuron loss
58.54
2
12547647 (1), 11030753 (1)
neuromuscular diseases
56.62
2
18974562 (1), 10735271 (1)
motor neuron disease
55.05
1
9073029 (1)
atrophy
43.84
4
12547647 (1), 10764048 (1), 14676483 (1)
spinal disorder
41.83
2
11896143 (1), 12445469 (1)
About this table Human Gene Mutation Database : NAIP Human Genome Epidemiology Navigator: NAIP (4 documents)
Medical News for NAIP (Possibly Related Articles in
Doctor's Guide )
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Publications for NAIP (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/150 PubMed articles for NAIP gene (see all 150
): The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. (PubMed id 7813013) 1, 2, 3, 4 Roy N.... Mackenzie A. (1995) Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP. (PubMed id 9503025) 1, 3, 4 Chen Q....MacKenzie A.E. (1998) Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191) 1, 3, 4 Liston P.... Korneluk R.G. (1996) The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022) 3, 4 Schmutz J.... Rubin E.M. (2004) A provisional transcript map of the spinal muscular atrophy (SMA) critical region. (PubMed id 7552146) 3, 4 van der Steege G.... Buys C.H.C.M. (1995) Functional human NAIP promoter and transcriptional elements of the human NAIP and psiNAIP genes. (PubMed id 11955612) 1, 3 Xu M.... Ikeda J.E. (2002) Neuronal apoptosis inhibitory protein is overexpressed in patients with unfavorable prognostic factors in breast cancer. (PubMed id 17923748) 1, 3 Choi J....Im Y.H. (2007) SMN2 and NAIP gene dosages in Vietnamese patients with spinal muscular atrophy. (PubMed id 18533950) 1, 3 Tran V.K....Nishio H. (2008) Molecular analysis of the SMN1 and NAIP genes in Iranian patients with spinal muscular atrophy. (PubMed id 18071605) 1, 3 Derakhshandeh-Peykar P....Farhud D.D. (2007) Deletion analysis of SMN1 and NAIP genes in Southern Chinese children with spinal muscular atrophy. (PubMed id 19198020) 1, 3 Liang Y.H....Zhang X.N. (2009)
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Genome Databases showing NAIP
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing NAIP
(According to HUGE )
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--
Specialized Databases showing NAIP (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for NAIP (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for NAIP:
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Incremental update: 13 Oct 2009