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NAIP Gene

protein-coding   GIFtS: 59

GC05M070301
NLR family, apoptosis inhibitory protein
(Previous name: baculoviral IAP repeat-containing 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BIRC1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BIRC1 2, 3, 5
FLJ18088 2
FLJ42520 2
FLJ58811 2
NLRB1 1, 2
OTTHUMP00000125255 2
psiNAIP 2
Descriptions
NLR family, BIR domain containing 1 2
NLR family, apoptosis inhibitory protein 2
Neuronal apoptosis inhibitory protein 2, 3
baculoviral IAP repeat-containing 1 1, 2
nucleotide-binding oligomerization domain, leucine rich
repeat and BIR domain containing 1 2
psi neuronal apoptosis inhibitory protein 2
External Ids
HGNC: 76341
Entrez Gene: 46712
UniProtKB: Q130753
Ensembl: ENSG000000817707
Search outside databases for aliases for NAIP gene

Previous GC identifer: GC05M070401

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAIP:
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region
contains at least four genes and repetitive elements which make it prone to rearrangements and
deletions. The repetitiveness and complexity of the sequence have also caused difficulty in
determining the organization of this genomic region. This copy of the gene is full length;
additional copies with truncations and internal deletions are also present in this region of
chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by
mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of
homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis
induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms
have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
Function: Prevents motor-neuron apoptosis induced by a variety of signals

Gene Wiki entry for NAIP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.1   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.1

NAIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M070301:     (about GC identifiers)

Start:
70,300,066 bp from pter
End:
70,356,697 bp from pter
Size:
56,632 bases
Orientation:
minus strand

1 alternative location:
Chr5+,c5_H2 69,358,495-69,415,104     
RefSeq DNA sequence:
NC_000005.8  NT_006713.14  NT_113801.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 1  
Size: 1403 amino acids; 159582 Da
Sequence caution: Sequence=AAC62261.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia :
2VM5 (3D)    
Secondary accessions: O75857 Q13730 Q59GI6 Q99796

REFSEQ proteins (2 alternative transcripts): 
NP_004527.2  NP_075043.1  


ENSEMBL proteins: 
ENSP00000194097 ENSP00000311089 ENSP00000370076 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (NAIP)
Human Recombinant Proteins from Abnova (NAIP)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
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Antibodies for NAIP: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of NAIP
Sigma-Aldrich Antibodies for NAIP
R&D Systems Antibodies for NAIP
Antibodies from Abcam (NAIP), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (NAIP)
Novus Biologicals Antibodies for NAIP

Assays for NAIP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR007111 NACHT_NTPase
 IPR001370 Prot_inh_I32_IAP
 IPR003593 ATPase_AAA+_core


   GeneDecks  NAIP for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q13075

ProtoNet protein and cluster: Q13075

1 Blocks protein family: IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
Similarity: Contains 3 BIR repeats
Similarity: Contains 1 NACHT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NAIP)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NAIP)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_022892

              Applied Biosystems Silencer® siRNAs for NAIP

              Sigma-Aldrich siRNA for NAIP  
                     Sigma-Aldrich shRNA for NAIP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004536
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004536
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004536 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004536

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
Function: Prevents motor-neuron apoptosis induced by a variety of signals

3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Naip1):

homeostasis/metabolismnervous systemnormal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0017111 nucleoside-triphosphatase activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


5 Sigma-Aldrich "Your Favorite Gene" Pathways for  NAIP  (Your Favorite Gene powered by Ingenuity) 
 Induction of Apoptosis by HIV1
 Amyotrophic Lateral Sclerosis Signaling
 Apoptosis Signaling
 Molecular Mechanisms of Cancer
 Death Receptor Signaling

   GeneDecks  NAIP for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  NAIP 


5/8 Interacting proteins for NAIP (ENSP000001940973) via UniProtKB, MINT, and/or STRING (see all 8 )
InteractantInteraction Details
GeneCardExternal ID(s)
DIABLOENSP000002671693STRING (score=.884)
CASP9ENSP000003302373STRING (score=.882)
HPCAENSP000003625663STRING (score=.827)
SMN2ENSP000003701173STRING (score=.794)
CASP3ENSP000003110323STRING (score=.78)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006915 apoptosis IEA--
GO:0006916 anti-apoptosis TAS8552191
GO:0007399 nervous system development TAS7813013
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAIP
2 Novoseek chemical compound relationships for NAIP gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
peptidoglycan 25.51 1 16940328 (1)
calcium 0.00 6 10899114 (5)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NAIP)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NAIP)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_022892

              Sigma-Aldrich siRNA for NAIP  
                     Sigma-Aldrich shRNA for NAIP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004536  NM_022892  

REFSEQ mRNAs for NAIP gene (2 alternative transcripts): 

NM_004536.2   NM_022892.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004536  NM_022892  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004536
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004536
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004536 

Additional cDNA sequence: 

AB048534.1 AB209123.1 AK124511.1 AK295115.1 AK309627.1 BC136273.1 BC143761.1 U19251.1 

12 DOTS entries:

DT.115455  DT.91919714  DT.99927684  DT.65287141  DT.65286481  DT.95197494  DT.100670959  DT.120845050 
DT.120845093  DT.215933  DT.456071  DT.99985602 

8 AceView cDNA sequences:

BF589758 NM_004536 AW137096 AA770519 AI204610 AI539635 BE672529 AA759208 

highest scoring ESTs for NAIP:

U19251 AA236415 AA401859 AA482660 AA534960 AA621150 AA662221 AA662615 AA759208 AA770519 

Unigene Cluster for NAIP:

NLR family, apoptosis inhibitory protein
Hs.654500  [show with all ESTs]
Unigene Representative Sequence: NM_004536


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000194097  ENST00000348972  ENST00000380700  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAIP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NAIP

1 / 2 / 3

7 probe-sets matching NAIP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

37277_at2, 3 U95-A 2 1.00 0.50 1.00 1.00 U19251 1.00 0.90 0.95 1

204861_s_at2, 3 U133-A 2 1.00 0.50 -- -- NM_004536 0.60 1.00 0.82 1

204860_s_at2, 3 U133-A 2 1.00 0.50 -- -- AI817801 0.60 1.00 0.82 1

239735_at*2 U133-B 17 0.27 0.06 -- -- -- -- -- -- --

204861_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --

204860_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --

239735_at*2 U133Plus2 17 0.27 0.06 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGCCTCAAGT

SOURCE GeneReport for Unigene cluster: Hs.654500

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
Tissue specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and
placenta, and to a lesser extent in spinal cord

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for NAIP gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
NAIP1   -- NLR family, apoptosis inhibitory protein 99.19(n)
98.57(a)
471523  XM_001156888.1  XP_001156888.1 
cow
(Bos taurus)
NAIP1   -- NLR family, apoptosis inhibitory protein 81.18(n)
71.98(a)
539780  XM_589415.3  XP_589415.3 
rat
(Rattus norvegicus)
RGD15599141   -- similar to neuronal apoptosis inhibitory protein 76.94(n)
67.48(a)
294691  XM_226743.4  XP_226743.4 
mouse
(Mus musculus)
Naip11, 5 13 (54.00 cM)5
NLR family, apoptosis inhibitory protein 11, 5 77.11(n)1
68.45(a)1
179401  NM_008670.21  NP_032696.21 
 AF0077695  AF1354915  (see all 14)
About this table        Species with no ortholog for NAIP

ENSEMBL Gene Tree for NAIP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for NAIP gene
LOC7285192  NLRC42  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/46 NCBI SNPs in NAIP are shown (see all 46 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 2)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs284097061,2
C70344007(+) AAGGAC/TGCAAG 1 A/A syn1 ese30--------
--
rs287518791,2
C70341309(+) GAAAAA/TAGGTG 1 -- int1 trp30--------
--
rs49762101,2
C70343220(-) TGAGAA/GCTCAA 1 -- int10--------
--
rs562480221,2
--70358210(-) ATACAC/TGAATG 1 -- ng310--------
--
rs351400581,2
--70344461(-) GATCT-/CCCCAG 1 S/L fra10--------
--
rs617576291,2
--70344018(+) TCTAGC/TCTCCT 1 A/T mis10--------
--
rs2114911,2
--70309550(+) ctccaG/Tcctgg 1 -- int10--------
--
rs716125561,2
--70340961(+) AAAAA-/AGAAAA 1 -- int10--------
--
rs284757821,2
--70344952(+) CGCGGG/TGGCTC 1 -- int10--------
--
rs668609711,2
--70340962(+) AAAAG-/AAAAAG 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for NAIP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600355

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
  • Mutated or deleted forms of NAIP have been found in individuals with severe spinal
    muscular atrophy (SMA) leading to the hypothesis that mutations in the NAIP locus may contribute
    to the SMA phenotype
  • 10/18 Novoseek disease relationships for NAIP gene (see all 18 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular atrophy spinal 96.31 60 9363657 (2), 9341874 (2), 17250498 (2), 9073029 (2) (see all 48)
    sma ii 93.86 8 8595417 (1), 18842367 (1), 9341874 (1), 7581364 (1) (see all 7)
    sma iii 92.60 6 8595417 (1), 8730281 (1), 15305106 (1), 10686495 (1) (see all 5)
    werdnig-hoffmann disease 82.08 1 12547647 (1)
    paralysis progressive 71.20 1 12547647 (1)
    neuron loss 58.54 2 12547647 (1), 11030753 (1)
    neuromuscular diseases 56.62 2 18974562 (1), 10735271 (1)
    motor neuron disease 55.05 1 9073029 (1)
    atrophy 43.84 4 12547647 (1), 10764048 (1), 14676483 (1)
    spinal disorder 41.83 2 11896143 (1), 12445469 (1)
    About this table

    Human Gene Mutation Database: NAIP
    Human Genome Epidemiology Navigator: NAIP (4 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/150 PubMed articles for NAIP gene (see all 150 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4671 HGNC: 7634 AceView: BIRC1 Ensembl:ENSG00000081770 euGenes: HUgn4671
    ECgene: NAIP H-InvDB: NAIP
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NAIP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NAIP-related products

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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NAIP Antibodies for NAIP
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NAIP Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search OriGene for NAIP
     Search Tocris compounds for NAIP




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NAIP

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