Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NAIP Gene

protein-coding   GIFtS: 57
GCID: GC05M070267

NLR Family, Apoptosis Inhibitory Protein

(Previous name: baculoviral IAP repeat-containing 1)
(Previous symbol: BIRC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NLR Family, Apoptosis Inhibitory Protein1 2     Nucleotide-Binding Oligomerization Domain1
BIRC11 2 3 5     NLRB12
Neuronal Apoptosis Inhibitory Protein2 3     Baculoviral IAP Repeat-Containing Protein 12
Baculoviral IAP Repeat-Containing 11     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And BIR
Domain Containing 12
BIR Domain Containing 11     Psi Neuronal Apoptosis Inhibitory Protein2
Leucine Rich Repeat And BIR Domain Containing 11     psiNAIP2
NLR Family1     

External Ids:    HGNC: 76341   Entrez Gene: 46712   Ensembl: ENSG000002494377   OMIM: 6003555   UniProtKB: Q130753   

Export aliases for NAIP gene to outside databases

Previous GC identifers: GC05M070401 GC05M070301


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NAIP Gene:
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least
four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and
complexity of the sequence have also caused difficulty in determining the organization of this genomic region.
This copy of the gene is full length; additional copies with truncations and internal deletions are also present
in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused
by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two
baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals.
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NAIP Gene:
NAIP (NLR family, apoptosis inhibitory protein) is a protein-coding gene. Diseases associated with NAIP include proximal spinal muscular atrophy, and juvenile spinal muscular atrophy. GO annotations related to this gene include nucleoside-triphosphatase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
Function: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit
the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at
'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in
pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the
prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron
apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
Function: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle
protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn
drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and
macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of
intracellular bacteria such as C.violaceum and L.pneumophila

Gene Wiki entry for NAIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NT_187651.1  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAIP gene promoter:
         AML1a   FOXD1   Pax-2   STAT5A   Pax-2a   MEF-2A   Pax-2b   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NAIP promoter sequence
   Search Chromatin IP Primers for NAIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

NAIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAIP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M070267:  view genomic region     (about GC identifiers)

Start:
70,264,310 bp from pter      End:
70,320,941 bp from pter
Size:
56,632 bases      Orientation:
minus strand

1 alternative location:
Chr5+,NW_003315917.2 385,732-442,341     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 1  
Size: 1403 amino acids; 159582 Da
Subunit: Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needle
protein CprI
Sequence caution: Sequence=AAC62261.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for NAIP:
2VM5 (3D)    
Secondary accessions: B9EG72 E9PHD1 O75857 Q13730 Q59GI6 Q8TDZ4 Q99796
Alternative splicing: 2 isoforms:  Q13075-1   Q13075-2   

Explore the universe of human proteins at neXtProt for NAIP: NX_Q13075

Explore proteomics data for NAIP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NAIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004527.2  NP_075043.1  

    ENSEMBL proteins: 
     ENSP00000428657   ENSP00000428363   ENSP00000429545   ENSP00000428226   ENSP00000429591  
     ENSP00000429154   ENSP00000424913   ENSP00000443944  

    NAIP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NAIP
    GenScript Custom Purified and Recombinant Proteins Services for NAIP
    Novus Biologicals NAIP Proteins
    Novus Biologicals NAIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NAIP

    NAIP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NAIP
    OriGene Antibodies for NAIP
    OriGene Custom Antibody Services for NAIP
    Novus Biologicals NAIP Antibodies
    Abcam antibodies for NAIP
    Cloud-Clone Corp. Antibodies for NAIP
    ThermoFisher Antibodies for NAIP
    LSBio Antibodies in human, mouse, rat for NAIP

    NAIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAIP
    Cloud-Clone Corp. CLIAs for NAIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NLR: Nucleotide-binding domain and leucine rich repeat containing
    BIRC: Baculoviral IAP repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NAIP
    NOD-like receptor family

    5 InterPro protein domains:
     IPR007111 NACHT_NTPase
     IPR001370 BIR
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR028789 Naip

    Graphical View of Domain Structure for InterPro Entry Q13075

    ProtoNet protein and cluster: Q13075

    1 Blocks protein domain: IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)

    UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
    Domain: Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain
    binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between
    pro-CASP9 and APAF1
    Similarity: Contains 3 BIR repeats
    Similarity: Contains 1 NACHT domain


    NAIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC1_HUMAN, Q13075
    Function: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit
    the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at
    'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in
    pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the
    prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron
    apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
    Function: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle
    protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn
    drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and
    macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of
    intracellular bacteria such as C.violaceum and L.pneumophila

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IMP--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    NAIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NAIP:
     Decreased influenza A/WSN/33 r 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Naip1):
     cellular  homeostasis/metabolism  nervous system  normal 

    NAIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NAIP: Naip1tm1Aem Naip1tm1Dgen

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAIP:
    hsa-mir-221-3p (MIRT005295)

    Block miRNA regulation of human, mouse, rat NAIP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NAIP:
    hsa-miR-4328
    SwitchGear 3'UTR luciferase reporter plasmidNAIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAIP
    Predesigned siRNA for gene silencing in human, mouse, rat NAIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAIP

    Clone
    Products:
         
    OriGene clones in human, mouse for NAIP (see all 10)
    OriGene ORF clones in mouse, rat for NAIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NAIP (NM_004536)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAIP
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAIP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0016323basolateral plasma membrane ISS--

    NAIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NAIP About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    3Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35
    4Legionellosis
    Legionellosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for NAIP
        NOD-like Receptor Signaling Pathways
    Apoptosis Signaling Pathways



    2 Kegg Pathways  (Kegg details for NAIP):
        NOD-like receptor signaling pathway
    Legionellosis


    NAIP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NAIP: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NAIP

    Selected Interacting proteins for NAIP (Q130753) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NLRC4Q9NPP43I2D: score=3 
    CASP9P552113I2D: score=2 
    HPCAP840743I2D: score=2 
    MAP3K7O433183I2D: score=2 
    XAF1Q6GPH43I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007399nervous system development TAS7813013
    GO:0043066negative regulation of apoptotic process ISS--
    GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA11896143
    GO:0043524negative regulation of neuron apoptotic process TAS18414036

    NAIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAIP (BIRC1)

    4 Novoseek inferred chemical compound relationships for NAIP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidoglycan 23.5 1 16940328 (1)
    cisplatin 20.1 3 11911975 (1), 16525642 (1), 15911101 (1)
    calcium 0 6 10899114 (5)
    cysteine 0 1 10205784 (1)



    NAIP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NAIP gene (2 alternative transcripts): 
    NM_004536.2  NM_022892.1  

    Unigene Cluster for NAIP:

    NLR family, apoptosis inhibitory protein
    Hs.654500  [show with all ESTs]
    Unigene Representative Sequence: NM_004536
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315147(uc003kaq.2 uc003kat.1) ENST00000517649(uc003kar.1 uc003kas.1)
    ENST00000523981 ENST00000508426 ENST00000514857 ENST00000508794 ENST00000447012
    ENST00000519014 ENST00000503719 ENST00000194097(uc011crs.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAIP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NAIP:
    hsa-miR-4328
    SwitchGear 3'UTR luciferase reporter plasmidNAIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAIP
    Predesigned siRNA for gene silencing in human, mouse, rat NAIP
    Clone
    Products:
         
    OriGene clones in human, mouse for NAIP (see all 10)
    OriGene ORF clones in mouse, rat for NAIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NAIP (NM_004536)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIP
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NAIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NAIP
      QuantiTect SYBR Green Assays in human, mouse, rat NAIP
      QuantiFast Probe-based Assays in human, mouse, rat NAIP

    Additional mRNA sequence: 

    AB048534.1 AB209123.1 AH003063.2 AK124511.1 AK295115.1 AK309627.1 BC136273.1 BC143761.1 
    U19251.1 

    10 DOTS entries:

    DT.115455  DT.99927684  DT.91919714  DT.65287141  DT.65286481  DT.95197494  DT.120845050  DT.120845093 
    DT.215933  DT.99985602 

    8 AceView cDNA sequences:

    AA759208 BF589758 AI204610 BE672529 AW137096 AI539635 AA770519 NM_004536 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NAIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTACAACT
    NAIP Expression
    About this image

    NAIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654500

    UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075
    Tissue specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a
    lesser extent in spinal cord

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NAIP: 
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NAIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NAIP
    QuantiTect SYBR Green Assays in human, mouse, rat NAIP
    QuantiFast Probe-based Assays in human, mouse, rat NAIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NAIP gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naip15
    Naip21
    NLR family, apoptosis inhibitory protein 15
    NLR family, apoptosis inhibitory protein 21
    76.84(n)1
    67.36(a)1
      13 (53.18 cM)5
    179481  NM_001126182.21  NP_001119654.11 
     1004077705 
    lizard
    (Anolis carolinensis)
    Reptilia NAIP6
    NLR family, apoptosis inhibitory protein
    44(a)
    1 ↔ 1
    2(16903786-16924343)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004909911 baculoviral IAP repeat-containing protein 1-like 52.86(n)
    40.36(a)
      100490991  XM_002934832.2  XP_002934878.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Iap26
    th6
    thread
    20(a)
    20(a)
    many ↔ many
    many ↔ many
    2R(11819675-11822330)
    3L(16031510-16044134)


    ENSEMBL Gene Tree for NAIP (if available)
    TreeFam Gene Tree for NAIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NAIP gene
    BIRC32  BIRC72  NLRC42  BIRC22  XIAP2  BIRC82  
    8 SIMAP similar genes for NAIP using alignment to 5 protein entries:     BIRC1_HUMAN (see all proteins):
    CNOT2    ECD    NSD1    XIAP    ATL2    ILP3
    BIRC7    BIRC5

    NAIP for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NAIP
    PGOHUM00000257104 PGOHUM00000257107 PGOHUM00000235620 PGOHUM00000235634


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NAIP (see all 262)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3753251741,2
    C--68898095(+) GAGGCC/TAAGTG 4 -- us2k10--------
    rs2012967161,2
    C--68898568(+) TATATC/TTGATC 4 -- us2k10--------
    rs2007440021,2
    --68901775(+) TTGAT-/AATATG
            
    AAAAG
    5 -- int1 us2k10--------
    rs2009669561,2
    F--68902992(+) CCTTCC/TACTGG 7 H Y mis1 ut511Minor allele frequency- T:0.01EU 577
    rs1504421,2
    C--70273694(+) atgggC/Tgcctg 7 -- int10--------
    rs5759091,2
    C--70273877(+) AAATTG/TGTGGC 7 -- int10--------
    rs1929496501,2
    --70273963(+) ATATAC/TATATA 2 -- int10--------
    rs3705814031,2
    C--70273972(+) ATATA-/ATATA 
            
    TATAT
    2 -- int10--------
    rs2005573791,2
    C--70275414(+) AAAAAA/TAATAA 2 -- int10--------
    rs2015358661,2
    C--70275417(+) AATAAA/TAATAA 7 -- int10--------

    HapMap Linkage Disequilibrium report for NAIP (70264310 - 70320941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NAIP (see all 73):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673843CNV Deletion23128226
    nsv471434CNV Duplication19718026
    dgv19n31CNV Duplication19718026
    dgv6149n71CNV Loss21882294
    dgv27n14CNV Loss18776910
    nsv881768CNV Loss21882294
    dgv6144n71CNV Loss21882294
    nsv821643CNV Loss15273396
    nsv882115CNV Loss21882294
    dgv6148n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NAIP
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NAIP
    DNA2.0 Custom Variant and Variant Library Synthesis for NAIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600355    OMIM disorders: --

    Selected diseases for NAIP (see all 28):    
    About MalaCards
    proximal spinal muscular atrophy    juvenile spinal muscular atrophy    werdnig-hoffmann disease    spinal muscular atrophy 1
    spinal muscular atrophy type 2    spinal cord disease    brown-vialetto-van laere syndrome    legionellosis
    spinal muscular atrophy    muscular atrophy    neuromuscular disease    fabry disease
    motor neuron disease    neuronitis    lateral sclerosis    amyotrophic lateral sclerosis
    esophageal cancer    glioblastoma multiforme    ischemia    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for NAIP:
    Muscular atrophy     Motor neuron disease

    NAIP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NAIP gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular atrophy spinal 96.1 60 9363657 (2), 9341874 (2), 17250498 (2), 9073029 (2) (see all 48)
    sma ii 94.1 8 8595417 (1), 18842367 (1), 9341874 (1), 7581364 (1) (see all 7)
    sma iii 92.2 6 8595417 (1), 8730281 (1), 15305106 (1), 10686495 (1) (see all 5)
    werdnig-hoffmann disease 81.5 1 12547647 (1)
    paralysis progressive 69.8 1 12547647 (1)
    neuron loss 56.9 2 12547647 (1), 11030753 (1)
    neuromuscular diseases 55.1 2 18974562 (1), 10735271 (1)
    motor neuron disease 53.7 1 9073029 (1)
    atrophy 44.1 4 12547647 (1), 10764048 (1), 14676483 (1)
    spinal disorder 40.3 2 11896143 (1), 12445469 (1)

    Genetic Association Database (GAD): NAIP
    Human Genome Epidemiology (HuGE) Navigator: NAIP (5 documents)

    Export disorders for NAIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NAIP gene, integrated from 10 sources (see all 169):
    (articles sorted by number of sources associating them with NAIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. (PubMed id 7813013)1, 2, 3, 9 Roy N.... Mackenzie A. (Cell 1995)
    2. Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes. (PubMed id 11955612)1, 2, 9 Xu M.... Ikeda J.-E. (Biochim. Biophys. Acta 2002)
    3. Molecular analysis of the SMN1 and NAIP genes in Iranian patients with spinal muscular atrophy. (PubMed id 18071605)1, 4, 9 Derakhshandeh-Peykar P....Farhud D.D. (Ann. Acad. Med. Singap. 2007)
    4. Deletion analysis of SMN1 and NAIP genes in Southern Chinese children with spinal muscular atrophy. (PubMed id 19198020)1, 4, 9 Liang Y.H....Zhang X.N. (J Zhejiang Univ Sci B 2009)
    5. Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy. (PubMed id 18842367)1, 4, 9 Watihayati M.S....Zilfalil B.A. (amp 2009)
    6. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. (PubMed id 11896143)1, 2, 9 Maier J.K....MacKenzie A.E. (J. Neurosci. 2002)
    7. Phenotype modifiers of spinal muscular atrophy: the number of SMN2 gene copies, deletion in the NAIP gene and probably gender influence the course of the disease. (PubMed id 19287802)1, 4, 9 Jedrzejowska M....Hausmanowa-Petrusewicz I. (Acta Biochim. Pol. 2009)
    8. Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP. (PubMed id 9503025)1, 2, 9 Chen Q....MacKenzie A.E. (Genomics 1998)
    9. Structures of BIR domains from human NAIP and cIAP2. (PubMed id 19923725)1, 2, 9 Herman M.D.... Nyman T. (Acta Crystallogr. F 2009)
    10. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 9 Liston P.... Korneluk R.G. (Nature 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4671 HGNC: 7634 AceView: BIRC1 Ensembl:ENSG00000249437 euGenes: HUgn4671
    ECgene: NAIP Kegg: 4671 H-InvDB: NAIP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NAIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NAIP gene:
    Search GeneIP for patents involving NAIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NAIP (NAIP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NAIP   OriGene RNAi products in human, mouse, rat for NAIP  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NAIP  
     OriGene qSTAR qPCR primer pairs in human, mouse for NAIP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NAIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NAIP   OriGene Custom Protein Services for NAIP  

     
     
     Block miRNA regulation of human, mouse, rat NAIP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NAIP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAIP Predesigned siRNA for gene silencing in human, mouse, rat NAIP
     QuantiFast Probe-based Assays in human, mouse, rat NAIP QuantiTect SYBR Green Assays in human, mouse, rat NAIP
     PCR Arrays including human, mouse / rat NAIP Search Chromatin IP Primers for NAIP
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NAIP  GeneGlobe Interaction Network for NAIP
     Regulatory tfbs in NAIP promoter
     GenScript Custom Purified and Recombinant Proteins Services for NAIP GenScript cDNA clones with any tag delivered in your preferred vector for NAIP
     GenScript Custom Assay Services for NAIP GenScript Custom overexpressing Cell Line Services for NAIP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NAIP (BIRC1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NAIP antibodies
     NAIP proteins
     NAIP lysates
     Antibodies for NAIP
     See all of Abcam's Antibodies, Kits and Proteins for NAIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NAIP
     Antibodies for NAIP
     ELISAs for NAIP
     CLIAs for NAIP



     Browse ESI BIO Cell Lines and PureStem Progenitors for NAIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIP
     SwitchGear 3'UTR luciferase reporter plasmids for NAIP
     SwitchGear Promoter luciferase reporter plasmids for NAIP
     ThermoFisher Antibodies for NAIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAIP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAIP
     LSBio Antibodies in human, mouse, rat for NAIP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NAIP gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4