NAIP Gene
protein-coding GIFtS: 57
GCID: GC05M070267
|
|
NLR family, apoptosis inhibitory protein(Previous name: baculoviral IAP repeat-containing 1 )
(Previous symbol: BIRC1)
| |
Aliases
for NAIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NLR Family, Apoptosis Inhibitory Protein1 2 | | Baculoviral IAP Repeat-Containing Protein 12 | | BIRC11 2 3 5 | | Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And BIR DomainContaining 12 | | NLRB11 2 | | Psi Neuronal Apoptosis Inhibitory Protein2 | | Neuronal Apoptosis Inhibitory Protein2 3 | | PsiNAIP1 | | Baculoviral IAP Repeat-Containing 11 | | |
Export aliases for NAIP gene to outside databasesPrevious GC identifers: GC05M070401 GC05M070301 |
Summaries
for NAIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAIP:
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least fourgenes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexityof the sequence have also caused difficulty in determining the organization of this genomic region. This copy of thegene is full length; additional copies with truncations and internal deletions are also present in this region ofchromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in aneighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor ofapoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcriptvariants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075Function: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit theautocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315'and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathologicalconditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinalmuscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deletedforms of NAIP have been found in individuals with severe spinal muscular atrophyFunction: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle proteinCprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assemblyand activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophagepyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellularbacteria such as C.violaceum and L.pneumophila
Gene Wiki entry for NAIP
|
Genomic Views
for NAIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAIP gene promoter:
AML1a FOXD1 Pax-2 STAT5A Pax-2a MEF-2A Pax-2b POU2F1 POU2F1a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13.2 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13.2NAIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M070267: view genomic region
(about GC identifiers)
Start:
|
70,264,310 bp from pter |
End:
|
70,320,941 bp from pter |
Size:
|
56,632 bases |
Orientation:
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minus strand |
|
Proteins
for NAIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075 (See
protein sequence)Recommended Name: Baculoviral IAP repeat-containing protein 1 Size: 1403 amino acids; 159582 Da
Subunit: Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needleprotein CprI
Sequence caution: Sequence=AAC62261.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from  and Proteopedia  for NAIP:2VM5 (3D)
Secondary accessions: B9EG72 O75857 Q13730 Q59GI6 Q99796Explore the universe of human proteins at neXtProt for NAIP: NX_Q13075
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13075
NAIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004527.2 NP_075043.1
ENSEMBL proteins: ENSP00000428657 ENSP00000428363 ENSP00000429545 ENSP00000428226 ENSP00000429591 ENSP00000429154 ENSP00000424913 ENSP00000443944
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NAIP for ontologies About GeneDecksing
NAIP Antibody Products:
Assay Products for NAIP: |
Protein
Domains /
Families
for NAIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAIP for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13075ProtoNet protein and cluster: Q13075 1 Blocks protein family: IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075Domain: Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain bindsto procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 andAPAF1Similarity: Contains 3 BIR repeatsSimilarity: Contains 1 NACHT domain |
Function
for NAIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075Function: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit theautocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315'and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathologicalconditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinalmuscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deletedforms of NAIP have been found in individuals with severe spinal muscular atrophyFunction: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle proteinCprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assemblyand activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophagepyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellularbacteria such as C.violaceum and L.pneumophila
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAIP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NAIP (NM_004536) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIP |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NAIP for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NAIP:
Animal Models:
Mouse knock-outs for NAIP: Naip1tm1Aem Naip1tm1Dgen
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Naip1):
NAIP for phenotypes About GeneDecksing
|
Pathways & Interactions
for NAIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 2 | Apoptosis and survival_Apoptotic TNF-family pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for NAIP
1 
Kegg Pathway (Kegg details for NAIP):
NAIP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAIP
5/9 Interacting proteins for NAIP (Q130753) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
NAIP for ontologies About GeneDecksing
|
Drugs & Compounds
for NAIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NAIP for compounds About GeneDecksing
 Browse Tocris compounds for NAIP
4 Novoseek chemical compound relationships for NAIP gene About this table
Search CenterWatch for drugs/clinical trials and news about NAIP / BIRC1
|
Transcripts
for NAIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAIP gene (2 alternative transcripts): NM_004536.2 NM_022892.1 Unigene Cluster for NAIP: NLR family, apoptosis inhibitory protein Hs.654500 [show with all ESTs]Unigene Representative Sequence: NM_00453610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000315147(uc003kaq.2 uc003kat.1) ENST00000517649(uc003kar.1 uc003kas.1)
ENST00000523981 ENST00000508426 ENST00000514857 ENST00000508794 ENST00000447012
ENST00000519014 ENST00000503719 ENST00000194097(uc011crs.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAIP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NAIP (NM_004536) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIP |
Additional cDNA sequence: AB048534.1 AB209123.1 AH003063.2 AK124511.1 AK295115.1 AK309627.1 BC136273.1 BC143761.1 U19251.1 10 DOTS entries: DT.115455 DT.99927684 DT.91919714 DT.65287141 DT.65286481 DT.95197494 DT.120845050 DT.120845093 DT.215933 DT.99985602 8 AceView cDNA sequences: BE672529 AW137096 NM_004536 AA770519 AI204610 AA759208 BF589758 AI539635
GeneLoc Exon Structure
|
Expression
for NAIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTACAACT
About this image
See NAIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAIP
SOURCE GeneReport for Unigene cluster: Hs.654500
UniProtKB/Swiss-Prot: BIRC1_HUMAN, Q13075Tissue specificity: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to alesser extent in spinal cord
SABiosciences Expression via Pathway-Focused PCR Arrays including NAIP:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NAIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIP |
Orthologs
for NAIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NAIP gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for NAIP (if available)
TreeFam Gene Tree for NAIP (if available) |
Paralogs
for NAIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAIP gene
- NLRC42
8 SIMAP similar genes for NAIP using alignment to 6 protein entries: BIRC1_HUMAN (see all proteins):psiNAIP CNOT2 NSD1 XIAP ATL2 ILP3
BIRC7 BIRC5
NAIP for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for NAIP
PGOHUM00000257104 PGOHUM00000257107 PGOHUM00000235620 PGOHUM00000235634
|
Genomic Variants
for NAIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAIP (70264310 - 70320941 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 37 variations for NAIP
15/35 CNVs (see all 35): 4452 69103 80949 80952 4449 31241 69097 69139 69140 69093 69108 69144 80948 3557 93092
2 Inversions: 37264 37263
Human Gene Mutation Database (HGMD): NAIP
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NAIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAIP for disorders About GeneDecksing
OMIM gene information: 600355
OMIM disorders: --
20/28  diseases for NAIP (see all 28): About MalaCardsspinal muscular atrophy brown-vialetto-van laere syndrome muscular atrophy proximal spinal muscular atrophy
werdnig-hoffmann disease spinal cord disease amyotrophic lateral sclerosis neuronitis
lateral sclerosis motor neuron disease neuromuscular disease fabry disease
neurodegenerative disease alzheimer's disease neurodegeneration prostate cancer, progression of
multiple sclerosis myeloid leukemia prostate cancer ischemia
2 diseases from the University of Copenhagen DISEASES database for NAIP:Muscular atrophy Spinal muscular atrophy 10/18 Novoseek disease relationships for NAIP gene (see all 18) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| muscular atrophy spinal |
96.1 |
60 |
9363657 (2), 9341874 (2), 17250498 (2), 9073029 (2) (see all 48) |
| sma ii |
94.1 |
8 |
8595417 (1), 18842367 (1), 9341874 (1), 7581364 (1) (see all 7) |
| sma iii |
92.2 |
6 |
8595417 (1), 8730281 (1), 15305106 (1), 10686495 (1) (see all 5) |
| werdnig-hoffmann disease |
81.5 |
1 |
12547647 (1) |
| paralysis progressive |
69.8 |
1 |
12547647 (1) |
| neuron loss |
56.9 |
2 |
12547647 (1), 11030753 (1) |
| neuromuscular diseases |
55.1 |
2 |
18974562 (1), 10735271 (1) |
| motor neuron disease |
53.7 |
1 |
9073029 (1) |
| atrophy |
44.1 |
4 |
12547647 (1), 10764048 (1), 14676483 (1) |
| spinal disorder |
40.3 |
2 |
11896143 (1), 12445469 (1) |
Human Genome Epidemiology (HuGE) Navigator: NAIP (5 documents)
Export disorders for NAIP gene to outside databases
|
Publications
for NAIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAIP gene, integrated from 9 sources (see all 166):
(articles sorted by number of sources associating them with NAIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. (PubMed id 7813013)1, 2, 3, 9 Roy N.... Mackenzie A. (1995)
- The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. (PubMed id 11896143)1, 2, 9 Maier J.K....MacKenzie A.E. (2002)
- Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP. (PubMed id 9503025)1, 2, 9 Chen Q....MacKenzie A.E. (1998)
- Structures of BIR domains from human NAIP and cIAP2. (PubMed id 19923725)1, 2, 9 Herman M.D....Nyman T. (2009)
- Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 9 Liston P.... Korneluk R.G. (1996)
- Integrity of ATP binding site is essential for effect ive inhibition of the intrinsic apoptosis pathway by NAIP. (PubMed id 21371431)1, 2 Karimpour S....Ghahremani M.H. (2011)
- IAPs: more than just inhibitors of apoptosis proteins . (PubMed id 18414036)1, 2 Dubrez-Daloz L....Cartier J. (2008)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
- A provisional transcript map of the spinal muscular atrophy (SMA) critical region. (PubMed id 7552146)1, 2 van der Steege G.... Buys C.H.C.M. (1995)
- Functional human NAIP promoter and transcriptional elements of the human NAIP and psiNAIP genes. (PubMed id 11955612)1, 9 Xu M.... Ikeda J.E. (2002)
|
External Searches for NAIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAIP gene:
Search GeneIP for patents involving NAIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NAIP | | OriGene shRNA RFP for NAIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAIP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAIP | | OriGene 3'-UTR Clone for NAIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAIP | | OriGene Custom Protein Services for NAIP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAIP | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAIP |
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| | | | Search Tocris compounds for NAIP |
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 | | | NAIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIP |
|  |  |  | | | | ThermoFisher Antibodies for NAIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIP |
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