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Aliases for NAIF1 Gene

Aliases for NAIF1 Gene

  • Nuclear Apoptosis Inducing Factor 1 2 3 5
  • C9orf90 3 4
  • Nuclear Apoptosis-Inducing Factor 1 2
  • Chromosome 9 Open Reading Frame 90 2
  • BA379C10.2 3

External Ids for NAIF1 Gene

Previous HGNC Symbols for NAIF1 Gene

  • C9orf90

Previous GeneCards Identifiers for NAIF1 Gene

  • GC09M129864
  • GC09M130823
  • GC09M100438

Summaries for NAIF1 Gene

GeneCards Summary for NAIF1 Gene

NAIF1 (Nuclear Apoptosis Inducing Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAIF1 Gene

  • Induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIF1 Gene

Genomics for NAIF1 Gene

Regulatory Elements for NAIF1 Gene

Promoters for NAIF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAIF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAIF1 Gene

Chromosome:
9
Start:
128,061,233 bp from pter
End:
128,068,206 bp from pter
Size:
6,974 bases
Orientation:
Minus strand

Genomic View for NAIF1 Gene

Genes around NAIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAIF1 Gene

Proteins for NAIF1 Gene

  • Protein details for NAIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YI7-NAIF1_HUMAN
    Recommended name:
    Nuclear apoptosis-inducing factor 1
    Protein Accession:
    Q69YI7
    Secondary Accessions:
    • B3KV81
    • Q8WU12

    Protein attributes for NAIF1 Gene

    Size:
    327 amino acids
    Molecular mass:
    35164 Da
    Quaternary structure:
    • Interacts with HARBI1.

    Alternative splice isoforms for NAIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAIF1 Gene

Proteomics data for NAIF1 Gene at MOPED

Post-translational modifications for NAIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NAIF1

No data available for DME Specific Peptides for NAIF1 Gene

Domains & Families for NAIF1 Gene

Protein Domains for NAIF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YI7

UniProtKB/Swiss-Prot:

NAIF1_HUMAN :
  • Belongs to the NAIF1 family.
Family:
  • Belongs to the NAIF1 family.
genes like me logo Genes that share domains with NAIF1: view

No data available for Gene Families for NAIF1 Gene

Function for NAIF1 Gene

Molecular function for NAIF1 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis.
genes like me logo Genes that share phenotypes with NAIF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAIF1 Gene

Localization for NAIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAIF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAIF1 Gene COMPARTMENTS Subcellular localization image for NAIF1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 16378748
genes like me logo Genes that share ontologies with NAIF1: view

Pathways & Interactions for NAIF1 Gene

SuperPathways for NAIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAIF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAIF1 Gene

Drugs & Compounds for NAIF1 Gene

No Compound Related Data Available

Transcripts for NAIF1 Gene

Unigene Clusters for NAIF1 Gene

Nuclear apoptosis inducing factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAIF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for NAIF1 Gene

GeneLoc Exon Structure for
NAIF1
ECgene alternative splicing isoforms for
NAIF1

Expression for NAIF1 Gene

mRNA expression in normal human tissues for NAIF1 Gene

Protein differential expression in normal tissues from HIPED for NAIF1 Gene

This gene is overexpressed in Heart (37.7), Peripheral blood mononuclear cells (19.5), and Blymphocyte (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAIF1 Gene



SOURCE GeneReport for Unigene cluster for NAIF1 Gene Hs.373606

mRNA Expression by UniProt/SwissProt for NAIF1 Gene

Q69YI7-NAIF1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NAIF1: view

Protein tissue co-expression partners for NAIF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NAIF1 Gene

Orthologs for NAIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAIF1 35
  • 99.29 (n)
  • 99.39 (a)
NAIF1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAIF1 36
  • 97 (a)
OneToOne
NAIF1 35
  • 91.03 (n)
  • 96.94 (a)
dog
(Canis familiaris)
Mammalia NAIF1 35
  • 90.62 (n)
  • 97.25 (a)
NAIF1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naif1 36
  • 94 (a)
OneToOne
Naif1 35
  • 88.07 (n)
  • 93.88 (a)
Naif1 16
oppossum
(Monodelphis domestica)
Mammalia NAIF1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAIF1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naif1 35
  • 87.67 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves NAIF1 35
  • 72.56 (n)
  • 74.45 (a)
NAIF1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naif1 35
  • 69.12 (n)
  • 68.9 (a)
zebrafish
(Danio rerio)
Actinopterygii naif1 36
  • 62 (a)
OneToMany
NAIF1 (1 of 3) 36
  • 18 (a)
OneToMany
NAIF1 (2 of 3) 36
  • 20 (a)
OneToMany
naif1 35
  • 69.97 (n)
  • 68.6 (a)
Species with no ortholog for NAIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAIF1 Gene

ENSEMBL:
Gene Tree for NAIF1 (if available)
TreeFam:
Gene Tree for NAIF1 (if available)

Paralogs for NAIF1 Gene

No data available for Paralogs for NAIF1 Gene

Variants for NAIF1 Gene

Sequence variations from dbSNP and Humsavar for NAIF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1970529 -- 128,062,315(-) AAGGC(A/G)AAGCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs4557800 -- 128,064,371(+) GCGCC(C/T)GGCCG intron-variant
rs10987855 -- 128,063,290(+) AAAAA(C/T)AGTGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10987856 -- 128,064,480(+) ACTAC(C/T)ACATG intron-variant
rs35915882 -- 128,061,066(+) AAAAA(-/A/AA)GCCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NAIF1 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv831727 CNV Loss 17160897
nsv471324 CNV Gain 18288195

Variation tolerance for NAIF1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAIF1 Gene

HapMap Linkage Disequilibrium report
NAIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIF1 Gene

Disorders for NAIF1 Gene

Relevant External Links for NAIF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAIF1

No disorders were found for NAIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAIF1 Gene

Publications for NAIF1 Gene

  1. Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis. (PMID: 16378748) Lv B. … Lou Y. (Int. J. Biochem. Cell Biol. 2006) 2 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  3. Upregulation of miR-24 promotes cell proliferation by targeting NAIF1 in non-small cell lung cancer. (PMID: 25725584) Zhao G. … Cui J. (Tumour Biol. 2015) 3
  4. NAIF1 inhibits gastric cancer cells migration and invasion via the MAPK pathways. (PMID: 25432142) Yang M. … Huang C. (J. Cancer Res. Clin. Oncol. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NAIF1 Gene

Sources for NAIF1 Gene

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