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Aliases for NAIF1 Gene

Aliases for NAIF1 Gene

  • Nuclear Apoptosis Inducing Factor 1 2 3
  • Nuclear Apoptosis-Inducing Factor 1 2 3
  • C9orf90 3 4
  • Chromosome 9 Open Reading Frame 90 2
  • BA379C10.2 3
  • C9orf90, 6

External Ids for NAIF1 Gene

Previous HGNC Symbols for NAIF1 Gene

  • C9orf90

Previous GeneCards Identifiers for NAIF1 Gene

  • GC09M129864
  • GC09M130823
  • GC09M100438

Summaries for NAIF1 Gene

GeneCards Summary for NAIF1 Gene

NAIF1 (Nuclear Apoptosis Inducing Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAIF1 Gene

  • Induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIF1 Gene

Genomics for NAIF1 Gene

Regulatory Elements for NAIF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAIF1 Gene

128,061,233 bp from pter
128,068,206 bp from pter
6,974 bases
Minus strand

Genomic View for NAIF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAIF1 Gene

Proteins for NAIF1 Gene

  • Protein details for NAIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear apoptosis-inducing factor 1
    Protein Accession:
    Secondary Accessions:
    • B3KV81
    • Q8WU12

    Protein attributes for NAIF1 Gene

    327 amino acids
    Molecular mass:
    35164 Da
    Quaternary structure:
    • Interacts with HARBI1.

    Alternative splice isoforms for NAIF1 Gene


neXtProt entry for NAIF1 Gene

Proteomics data for NAIF1 Gene at MOPED

Post-translational modifications for NAIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NAIF1

No data available for DME Specific Peptides for NAIF1 Gene

Domains for NAIF1 Gene

Protein Domains for NAIF1 Gene


Suggested Antigen Peptide Sequences for NAIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NAIF1 family.
  • Belongs to the NAIF1 family.
genes like me logo Genes that share domains with NAIF1: view

No data available for Gene Families for NAIF1 Gene

Function for NAIF1 Gene

Molecular function for NAIF1 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis.

Gene Ontology (GO) - Molecular Function for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NAIF1: view

Phenotypes for NAIF1 Gene

GenomeRNAi human phenotypes for NAIF1:
genes like me logo Genes that share phenotypes with NAIF1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAIF1 Gene

Localization for NAIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAIF1 Gene

Subcellular locations from

Jensen Localization Image for NAIF1 Gene COMPARTMENTS Subcellular localization image for NAIF1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16378748
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 16378748
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NAIF1: view

Pathways for NAIF1 Gene

SuperPathways for NAIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IDA 16378748
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IDA 16378748
genes like me logo Genes that share ontologies with NAIF1: view

No data available for Pathways by source for NAIF1 Gene

Transcripts for NAIF1 Gene

Unigene Clusters for NAIF1 Gene

Nuclear apoptosis inducing factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAIF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAIF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NAIF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAIF1 Gene

mRNA expression in normal human tissues for NAIF1 Gene

Protein differential expression in normal tissues for NAIF1 Gene

This gene is overexpressed in Heart (37.7), Peripheral blood mononuclear cells (19.5), and Blymphocyte (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAIF1 Gene

SOURCE GeneReport for Unigene cluster for NAIF1 Gene Hs.373606

mRNA Expression by UniProt/SwissProt for NAIF1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with NAIF1: view

Expression partners for NAIF1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NAIF1 Gene

Orthologs for NAIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAIF1 35
  • 91.03 (n)
  • 96.94 (a)
NAIF1 36
  • 97 (a)
(Canis familiaris)
Mammalia NAIF1 35
  • 90.62 (n)
  • 97.25 (a)
NAIF1 36
  • 97 (a)
(Mus musculus)
Mammalia Naif1 35
  • 88.07 (n)
  • 93.88 (a)
Naif1 16
Naif1 36
  • 94 (a)
(Pan troglodytes)
Mammalia NAIF1 35
  • 99.29 (n)
  • 99.39 (a)
NAIF1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Naif1 35
  • 87.67 (n)
  • 95.11 (a)
(Monodelphis domestica)
Mammalia NAIF1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia NAIF1 36
  • 88 (a)
(Gallus gallus)
Aves NAIF1 35
  • 72.56 (n)
  • 74.45 (a)
NAIF1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia naif1 35
  • 69.12 (n)
  • 68.9 (a)
(Danio rerio)
Actinopterygii naif1 35
  • 69.97 (n)
  • 68.6 (a)
naif1 36
  • 62 (a)
NAIF1 (1 of 3) 36
  • 18 (a)
NAIF1 (2 of 3) 36
  • 20 (a)
Species with no ortholog for NAIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAIF1 Gene

Gene Tree for NAIF1 (if available)
Gene Tree for NAIF1 (if available)

Paralogs for NAIF1 Gene

No data available for Paralogs for NAIF1 Gene

Variants for NAIF1 Gene

Sequence variations from dbSNP and Humsavar for NAIF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1970529 -- 128,062,315(-) AAGGC(A/G)AAGCT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs4557800 -- 128,064,371(+) GCGCC(C/T)GGCCG intron-variant
rs4836605 -- 128,065,689(+) CCACT(A/G)AGAAT intron-variant
rs7854266 -- 128,062,515(+) GGCCA(C/T)AGGGC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs10760528 -- 128,065,066(+) CACAC(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAIF1 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv831727 CNV Loss 17160897
nsv471324 CNV Gain 18288195

Relevant External Links for NAIF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIF1 Gene

Disorders for NAIF1 Gene

No disorders were found for NAIF1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NAIF1 Gene

Publications for NAIF1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis. (PMID: 16378748) Lv B. … Lou Y. (Int. J. Biochem. Cell Biol. 2006) 2 3 4
  3. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L. … Ivics Z. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NAIF1 Gene

Sources for NAIF1 Gene

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