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Aliases for NAIF1 Gene

Aliases for NAIF1 Gene

  • Nuclear Apoptosis Inducing Factor 1 2 3 5
  • Nuclear Apoptosis-Inducing Factor 1 2 3
  • C9orf90 3 4
  • Chromosome 9 Open Reading Frame 90 2
  • BA379C10.2 3

External Ids for NAIF1 Gene

Previous HGNC Symbols for NAIF1 Gene

  • C9orf90

Previous GeneCards Identifiers for NAIF1 Gene

  • GC09M129864
  • GC09M130823
  • GC09M100438

Summaries for NAIF1 Gene

GeneCards Summary for NAIF1 Gene

NAIF1 (Nuclear Apoptosis Inducing Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAIF1 Gene

  • Induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIF1 Gene

Genomics for NAIF1 Gene

Regulatory Elements for NAIF1 Gene

Enhancers for NAIF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F128065 0.4 ENCODE 25.7 +0.6 611 4.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YY1 ZNF207 SPOUT1 ZNF79 SNORA65 LOC101929314 CDK9 LOC102723566 NAIF1 RPL12 ENSG00000272696 ANGPTL2
GH09F128096 1 Ensembl ENCODE 17.8 -32.7 -32668 9.0 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 NAIF1 PTGES2 CIZ1 ZNF79 PTGES2-AS1 SLC25A25-AS1 SLC25A25 LCN2 C9orf16 DNM1
GH09F127962 1.2 FANTOM5 Ensembl ENCODE 13.5 +94.9 94859 22.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 PIP5KL1 DPM2 SPOUT1 LOC101929270 LOC105376284 SLC25A25 NAIF1 ENSG00000230848 CDK9 PTRH1
GH09F128043 1 Ensembl ENCODE 12.5 +24.4 24423 1.3 ELF3 ARID4B THRB RAD21 RARA YY1 SLC30A9 THAP11 SP5 MIER2 NAIF1 SLC25A25 FAM102A DPM2 LOC105376284 ENSG00000230848
GH09F128045 0.2 ENCODE 12.5 +20.9 20913 2.7 ESRRA ZFP64 RAD21 GATA3 CTBP1 CBX5 NFYB MAFK TCF7L2 ZNF687 NAIF1 SLC25A25 FAM102A DPM2 LOC105376284 SLC25A25-AS1 ENSG00000230848
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAIF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAIF1 Gene

128,061,233 bp from pter
128,068,206 bp from pter
6,974 bases
Minus strand

Genomic View for NAIF1 Gene

Genes around NAIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAIF1 Gene

Proteins for NAIF1 Gene

  • Protein details for NAIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear apoptosis-inducing factor 1
    Protein Accession:
    Secondary Accessions:
    • B3KV81
    • Q8WU12

    Protein attributes for NAIF1 Gene

    327 amino acids
    Molecular mass:
    35164 Da
    Quaternary structure:
    • Interacts with HARBI1.

    Alternative splice isoforms for NAIF1 Gene


neXtProt entry for NAIF1 Gene

Post-translational modifications for NAIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAIF1 Gene

Domains & Families for NAIF1 Gene

Protein Domains for NAIF1 Gene


Suggested Antigen Peptide Sequences for NAIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NAIF1 family.
  • Belongs to the NAIF1 family.
genes like me logo Genes that share domains with NAIF1: view

No data available for Gene Families for NAIF1 Gene

Function for NAIF1 Gene

Molecular function for NAIF1 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis.

Gene Ontology (GO) - Molecular Function for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with NAIF1: view
genes like me logo Genes that share phenotypes with NAIF1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAIF1 Gene

Localization for NAIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAIF1 Gene

Subcellular locations from

Jensen Localization Image for NAIF1 Gene COMPARTMENTS Subcellular localization image for NAIF1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16378748
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NAIF1: view

Pathways & Interactions for NAIF1 Gene

SuperPathways for NAIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0030308 negative regulation of cell growth IDA 16378748
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IDA 16378748
genes like me logo Genes that share ontologies with NAIF1: view

No data available for Pathways by source and SIGNOR curated interactions for NAIF1 Gene

Transcripts for NAIF1 Gene

Unigene Clusters for NAIF1 Gene

Nuclear apoptosis inducing factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAIF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NAIF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAIF1 Gene

Protein differential expression in normal tissues from HIPED for NAIF1 Gene

This gene is overexpressed in Heart (37.7), Peripheral blood mononuclear cells (19.5), and Blymphocyte (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAIF1 Gene

Protein tissue co-expression partners for NAIF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAIF1 Gene:


SOURCE GeneReport for Unigene cluster for NAIF1 Gene:


mRNA Expression by UniProt/SwissProt for NAIF1 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NAIF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NAIF1 Gene

Orthologs for NAIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAIF1 34 35
  • 99.29 (n)
(Bos Taurus)
Mammalia NAIF1 34 35
  • 91.03 (n)
(Canis familiaris)
Mammalia NAIF1 34 35
  • 90.62 (n)
(Mus musculus)
Mammalia Naif1 34 16 35
  • 88.07 (n)
(Ornithorhynchus anatinus)
Mammalia NAIF1 35
  • 88 (a)
(Rattus norvegicus)
Mammalia Naif1 34
  • 87.67 (n)
(Monodelphis domestica)
Mammalia NAIF1 35
  • 86 (a)
(Gallus gallus)
Aves NAIF1 34 35
  • 72.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia naif1 34
  • 69.12 (n)
(Danio rerio)
Actinopterygii naif1 34 35
  • 69.97 (n)
NAIF1 (2 of 3) 35
  • 20 (a)
NAIF1 (1 of 3) 35
  • 18 (a)
Species where no ortholog for NAIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAIF1 Gene

Gene Tree for NAIF1 (if available)
Gene Tree for NAIF1 (if available)

Paralogs for NAIF1 Gene

No data available for Paralogs for NAIF1 Gene

Variants for NAIF1 Gene

Sequence variations from dbSNP and Humsavar for NAIF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10739706 -- 128,069,050(+) TATTG(A/G)GGTTT intron-variant, upstream-variant-2KB
rs10760528 -- 128,065,066(+) CACAC(A/G)CTCTT intron-variant
rs10819342 -- 128,060,856(+) GACCT(C/T)GTGAT downstream-variant-500B
rs10819343 -- 128,067,408(+) GAAAA(C/G)CGGCC upstream-variant-2KB
rs10987855 -- 128,063,290(+) AAAAA(C/T)AGTGC intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAIF1 Gene

Variant ID Type Subtype PubMed ID
nsv1054891 CNV gain 25217958
nsv471324 CNV gain 18288195
nsv831727 CNV loss 17160897

Variation tolerance for NAIF1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAIF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIF1 Gene

Disorders for NAIF1 Gene

Relevant External Links for NAIF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAIF1 Gene

Publications for NAIF1 Gene

  1. Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis. (PMID: 16378748) Lv B. … Lou Y. (Int. J. Biochem. Cell Biol. 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  3. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L. … Ivics Z. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NAIF1 Gene

Sources for NAIF1 Gene

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