NAIF1 Gene
protein-coding GIFtS: 44
GCID: GC09M130823
|
|
nuclear apoptosis inducing factor 1(Previous name: chromosome 9 open reading frame 90 )
(Previous symbol: C9orf90)
| |
Aliases
for NAIF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Apoptosis Inducing Factor 11 2 | | Chromosome 9 Open Reading Frame 901 | | C9orf901 2 3 5 | | RP11-379C10.22 | | BA379C10.21 | | Nuclear Apoptosis-Inducing Factor 12 | | DKFZp762G1991 | | |
Export aliases for NAIF1 gene to outside databasesPrevious GC identifers: GC09M129864 GC09M100438 |
Summaries
for NAIF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NAIF1_HUMAN, Q69YI7Function: Induces apoptosis
|
Genomic Views
for NAIF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAIF1 gene promoter:
Elk-1 NF-E2 p45 c-Ets-1 NRF-2 CBF-A CBF-B CP1A NF-Y NF-E2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAIF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAIF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11NAIF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M130823: view genomic region
(about GC identifiers)
Start:
|
130,823,512 bp from pter |
End:
|
130,830,485 bp from pter |
Size:
|
6,974 bases |
Orientation:
|
minus strand |
|
Proteins
for NAIF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAIF1_HUMAN, Q69YI7 (See
protein sequence)Recommended Name: Nuclear apoptosis-inducing factor 1 Size: 327 amino acids; 35164 Da
Subunit: Interacts with HARBI1
Subcellular location: Nucleus
Secondary accessions: B3KV81 Q8WU12Alternative splicing: 2 isoforms: Q69YI7-1 Q69YI7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NAIF1: NX_Q69YI7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q69YI7
NAIF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_931045.1
ENSEMBL proteins: ENSP00000362170
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
NAIF1 for ontologies About GeneDecksing
NAIF1 Antibody Products:
Assay Products for NAIF1: |
Protein
Domains /
Families
for NAIF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAIF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q69YI7ProtoNet protein and cluster: Q69YI7 UniProtKB/Swiss-Prot: NAIF1_HUMAN, Q69YI7Similarity: Belongs to the NAIF1 family |
Function
for NAIF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAIF1_HUMAN, Q69YI7Function: Induces apoptosis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAIF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAIF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NAIF1 (NM_197956) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAIF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIF1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
NAIF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NAIF1:
|
Pathways & Interactions
for NAIF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAIF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for NAIF1 (Q69YI73 ENSP000003621704) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
NAIF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NAIF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAIF1
Search CenterWatch for drugs/clinical trials and news about NAIF1
|
Transcripts
for NAIF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAIF1 gene: NM_197956.3 Unigene Clusters for NAIF1: Nuclear apoptosis inducing factor 1 Hs.373606 [show with all ESTs], Hs.740682 [show with all ESTs]Unigene Representative Sequences: NM_197956, BX3592235 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373078(uc004bta.3) ENST00000470245(uc022bnv.1) ENST00000488519
ENST00000466139 ENST00000496649
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAIF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAIF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAIF1 (NM_197956) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAIF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIF1 |
Additional cDNA sequence: BC047160.1 6 DOTS entries: DT.97764185 DT.112629 DT.91687588 DT.91990219 DT.91849110 DT.100748534 24/91 AceView cDNA sequences (see all 91): AI417373 AA642586 AA359485 AI752966 BM740522 CA310459 BM511394 BM757831 AW079405 AA885000 AI969211 CA312400 AA927393 CR591717 CA426093 CA427966 BC013371 AA411902 CA426906 AA340072 BX103094 BM740427 BF796375 BU162007
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NAIF1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NAIF1
|
Expression
for NAIF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAIF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGACTCTT
About this image
See NAIF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAIF1
SOURCE GeneReport for Unigene clusters: Hs.373606 Hs.740682
UniProtKB/Swiss-Prot: NAIF1_HUMAN, Q69YI7Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for NAIF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAIF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAIF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAIF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAIF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIF1 |
Orthologs
for NAIF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NAIF1 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for NAIF1 (if available)
TreeFam Gene Tree for NAIF1 (if available) |
Paralogs
for NAIF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NAIF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAIF1 (130823512 - 130830485 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAIF1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAIF1 |
|
Disorders
/ Diseases
for NAIF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAIF1 for disorders About GeneDecksing
OMIM gene information: 610673
OMIM disorders: --
4  diseases for NAIF1: About MalaCardsesophageal carcinoma esophagitis gastric cancer carcinoma
Export disorders for NAIF1 gene to outside databases
|
Publications
for NAIF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAIF1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NAIF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis. (PubMed id 16378748)1, 2, 3 Lv B.... Lou Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PubMed id 18339812)1, 2 Sinzelle L....Ivics Z. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- NAIF1 is down-regulated in gastric cancer and promote s apoptosis through the caspase-9 pathway in human MKN45 cells. (PubMed id 21286669)1 Luo Q....Huang C. (2011)
- Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for NAIF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAIF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAIF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAIF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAIF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAIF1 gene:
Search GeneIP for patents involving NAIF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAIF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAIF1 | | | OriGene Protein Over-expression Lysate for NAIF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAIF1 | | OriGene 3'-UTR Clone for NAIF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAIF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAIF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAIF1 | | OriGene Custom Protein Services for NAIF1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAIF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAIF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAIF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAIF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAIF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAIF1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NAIF1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NAIF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAIF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for NAIF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAIF1 |
|
|
|
|
