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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAGPA Gene

protein-coding   GIFtS: 53
GCID: GC16M005014

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

 Explore 1 disease affiliated with
NAGPA via our new
 Human Malady Compendium 
Biological research products
for NAGPA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
N-Acetylglucosamine-1-Phosphodiester Alpha-N-Acetylglucosaminidase1 2     Phosphodiester Alpha-GlcNAcase2 3
UCE1 2 5     Alpha-N-Acetylglucosaminyl Phosphodiesterase2
APAA1 2     Lysosomal Alpha-N-Acetylglucosaminidase2
Mannose 6-Phosphate-Uncovering Enzyme2 3     EC 3.1.4.453

External Ids:    HGNC: 173781   Entrez Gene: 511722   Ensembl: ENSG000001031747   OMIM: 6079855   UniProtKB: Q9UK233   

Export aliases for NAGPA gene to outside databases

Previous GC identifers: GC16M005107 GC16M005075


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAGPA:
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This
gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker
on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine
(GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most
likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers.
In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking
it between lysosomes, the plasma membrane, and trans-Golgi network. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NAGPA_HUMAN, Q9UK23
Function: Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme
oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step

Gene Wiki entry for NAGPA


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAGPA gene promoter:
         GR   SREBP-1c   Tal-1beta   Nkx5-1   SREBP-1b   E47   AREB6   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAGPA promoter sequence
   Search SABiosciences Chromatin IP Primers for NAGPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAGPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NAGPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAGPA gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M005014:  view genomic region     (about GC identifiers)

Start:
5,074,845 bp from pter      End:
5,084,142 bp from pter
Size:
9,298 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NAGPA_HUMAN, Q9UK23 (See protein sequence)
Recommended Name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor  
Size: 515 amino acids; 56073 Da
Subunit: Homotetramer arranged as two disulfide-linked homodimers (By similarity)
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Note=Cis/medial Golgi
Secondary accessions: B2RAS1 Q96EJ8
Alternative splicing: 3 isoforms:  Q9UK23-1   Q9UK23-2   Q9UK23-3   

Explore the universe of human proteins at neXtProt for NAGPA: NX_Q9UK23

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UK23

  • NAGPA Protein expression data from MOPED and PaxDb:    About this image 
    NAGPA Protein Expression
    REFSEQ proteins: NP_057340.2  
    ENSEMBL proteins: 
     ENSP00000310998   ENSP00000371381   ENSP00000455900   ENSP00000467385   ENSP00000465949  
     ENSP00000465523   ENSP00000468270   ENSP00000464994  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    NAGPA for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NAGPA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018711 DUF2233
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9UK23

    ProtoNet protein and cluster: Q9UK23

    UniProtKB/Swiss-Prot: NAGPA_HUMAN, Q9UK23
    Domain: The tyrosine-based internalization signal may be essential for its retrieval from the plasma membrane to the
    TGN
    Domain: The C-terminal NPFKD sequence is an attractive candidate for either an endocytosis signal acting at the plasma
    membrane or a retrieval signal acting at the TGN to return the enzyme to the cis/medial-Golgi
    Similarity: Contains 1 EGF-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAGPA_HUMAN, Q9UK23
    Function: Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme
    oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step
    Catalytic activity: Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H(2)O = N-acetyl-D-glucosamine +
    glycoprotein phospho-D-mannose

         Enzyme Number (IUBMB): EC 3.1.4.451

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003944N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity IEA--
         
    NAGPA for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nagpa):
     cellular 

    NAGPA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NAGPA 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysosome
    Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NAGPA):
        Lysosome

    UniProtKB/Swiss-Prot: NAGPA_HUMAN, Q9UK23
    Pathway: Protein modification; protein glycosylation


    NAGPA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAGPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NAGPA (Q9UK233 ENSP000003109984) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FURINP099583, ENSP000002681714I2D: score=2 STRING: ENSP00000268171
    AP2A1O957823, ENSP000003519264I2D: score=2 STRING: ENSP00000351926
    EPS15P425663, ENSP000003607984I2D: score=3 STRING: ENSP00000360798
    DEGS1ENSP000003164764STRING: ENSP00000316476
    ZHX2ENSP000003147094STRING: ENSP00000314709
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS10551838
    GO:0006464cellular protein modification process TAS10551838
    GO:0006486protein glycosylation IEA--
    GO:0006622protein targeting to lysosome TAS10551838
    GO:0007040lysosome organization TAS10551838

    NAGPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAGPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAGPA

    2 HMDB Compounds for NAGPA    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for NAGPA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Acetyl-D-glucosamine2-Acetamido-2-deoxy-D-glucose (see all 4)7512-17-6target--8294420 9722550 17139284 17016423 17927214

    5 Novoseek chemical compound relationships for NAGPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 89.4 12 15864430 (1), 12058031 (1), 17927214 (1), 8294420 (1) (see all 7)
    udp-n-acetylglucosamine 74.4 2 8294420 (1), 2167847 (1)
    phosphodiester 71.5 15 8294420 (4), 10551838 (4), 7786023 (2)
    n-acetylglucosamine 71.5 6 15864430 (1), 12058031 (1), 7786023 (1), 11408573 (1)
    mannose 43.7 2 12058031 (1), 11723124 (1)

    Search CenterWatch for drugs/clinical trials and news about NAGPA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAGPA gene: 
    NM_016256.3  

    Unigene Cluster for NAGPA:

    N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
    Hs.21334  [show with all ESTs]
    Unigene Representative Sequence: NM_016256
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312251(uc002cyg.3) ENST00000381955(uc010buc.3) ENST00000564397
    ENST00000562746(uc002cyh.3) ENST00000568202 ENST00000563578 ENST00000566137
    ENST00000567739 ENST00000569296 ENST00000565876 ENST00000568528 ENST00000562346
    ENST00000562037 ENST00000569793 ENST00000591478 ENST00000561580(uc010uxx.2)
    ENST00000564922

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF052111.1 AF187072.1 AK025570.1 AK026122.1 AK127952.1 AK302916.1 AK314320.1 

    11 DOTS entries:

    DT.100790624  DT.312162  DT.100790628  DT.95199040  DT.92023445  DT.100790623  DT.95280284  DT.100024248 
    DT.100767383  DT.87010533  DT.92424627 

    24/131 AceView cDNA sequences (see all 131):

    BI193076 AA047671 BM457386 CR598113 CB123089 CR601621 CR599974 BU859544 
    AW239249 AL524697 BU844409 AI452628 BI193492 BQ016262 BX342155 BU608370 
    BX401157 BG703600 AI080697 BX419558 BI518126 BF797606 BX091704 BX335041 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NAGPA (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ·
    SP1:                                      -                 -                                                                                                   
    SP2:                                      -                 -                       -     -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                      -                 -                       -     -     -     -     -     -     -     -     -     -     -               
    SP5:                                -     -                 -                       -     -                                                                     

    ExUns: 13c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NAGPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAGPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTACAGACC
    NAGPA Expression
    About this image
    See NAGPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAGPA

    SOURCE GeneReport for Unigene cluster: Hs.21334

    UniProtKB/Swiss-Prot: NAGPA_HUMAN, Q9UK23
    Tissue specificity: Isoform 2 may be brain-specific

        SABiosciences Expression via Pathway-Focused PCR Array including NAGPA: 
              Glycosylation in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NAGPA gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nagpa1 , 5 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase1, 5 82.39(n)1
    80.78(a)1
      16 (2.51 cM)5
    274261  NM_013796.31  NP_038824.21 
     51952895 
    chicken
    (Gallus gallus)
    Aves NAGPA1 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 68.22(n)
    67.89(a)
      416395  XM_414709.3  XP_414709.3 
    lizard
    (Anolis carolinensis)
    Reptilia NAGPA6
    --
    59(a)
    1 ↔ 1
    GL343263.1(945122-962999)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1655341 zgc:165534 60.26(n)
    58.97(a)
      569719  NM_001109715.1  NP_001103185.1 


    ENSEMBL Gene Tree for NAGPA (if available)
    TreeFam Gene Tree for NAGPA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAGPA gene
    STAB22  STAB12  MEGF102  SCARF22  MEGF62  SCARF12  MEGF112  TNFAIP62  
    PEAR12  

    NAGPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 NCBI SNPs in NAGPA are shown (see all 294    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127216041,2
    --5040838(+) ATGCCA/C/GTTGTG 1 -- ds50011CSA 2
    rs611411281,2
    --5041050(+) TGACAA/GGAAAT 1 -- ut310--------
    rs9178971,2
    C,F,H--5041210(-) TGCCAA/GCGAAC 1 -- ut31 ese311Minor allele frequency- G:0.02MN NS EA NA WA 858
    rs598462911,2
    --5041249(+) TTGGCA/GGTGCG 1 -- ut310--------
    rs8878551,2
    C,F,H--5041397(-) GATAGC/GACTTG 1 -- ut318Minor allele frequency- G:0.01NA EA MN NS 838
    rs133806131,2
    C,H--5041484(+) AGCCAG/AACCGT 1 -- ut314Minor allele frequency- A:0.00NS EA 386
    rs758302521,2
    F--5041837(+) TAGATA/TGCACT 1 -- int11Minor allele frequency- T:0.18WA 118
    rs714025811,2
    C--5043453(+) GAGAT-/GG    
       GAGGA
    GGGAG
    1 -- int11Minor allele frequency- GGGAGGA:0.50NA 2
    rs2000526841,2
    C--5043458(+) GGGAGA/GANNNN 1 -- int10--------
    rs118656551,2
    C,F,H--5043576(+) CTGCCC/TTCCCT 1 -- int11Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for NAGPA (5074845 - 5084142 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for NAGPA
         6 CNVs: 9755 8811 5436 3101 3989 72444
    Human Gene Mutation Database (HGMD): NAGPA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAGPA
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NAGPA for disorders           About GeneDecksing

    OMIM gene information: 607985    OMIM disorders: --

    1 disease for NAGPA:    About MalaCards
    mucopolysaccharidosis

    2 diseases from the University of Copenhagen DISEASES database for NAGPA:
    Speech disorder     Mucolipidosis

    Export disorders for NAGPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAGPA gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with NAGPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N- acetylglucosaminidase. (PubMed id 10551838)1, 2, 3, 9 Kornfeld R.H.... Canfield W.M. (1999)
    2. Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. (PubMed id 12058031)1, 3, 9 Do H....Kornfeld S. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Purification and multimeric structure of bovine N-ace tylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (PubMed id 9722550)1, 7 Kornfeld R....Canfield W.M. (1998)
    6. Purification and kinetic parameters of bovine liver N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (PubMed id 8294420)7, 9 Mullis K.G....Kornfeld R.H. (1994)
    7. Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network. (PubMed id 11408573)1, 9 Rohrer J. and Kornfeld R. (2001)
    8. Purification and characterization of human serum N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (PubMed id 7786023)1, 9 Lee J.K. and Pierce M. (1995)
    9. Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme. (PubMed id 11723124)1, 9 Lee W.S....Kornfeld S. (2002)
    10. Purification and characterization of human lymphoblast N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (PubMed id 8922957)1, 9 Page T....Miller A.L. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51172 HGNC: 17378 AceView: NAGPA Ensembl:ENSG00000103174 euGenes: HUgn51172
    ECgene: NAGPA Kegg: 51172 H-InvDB: NAGPA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAGPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAGPA gene:
    Search GeneIP for patents involving NAGPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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