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NAGLU Gene

protein-coding GIFtS: 59

GC17P037941

N-acetylglucosaminidase, alpha-
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.2.1.50 ^³
MPS-IIIB ^²
MPS3B ^²
N-acetyl-alpha-glucosaminidase ^², ³
NAG ^¹, ², ³
UFHSD ^²
UFHSD1 ^³
alpha-N-acetylglucosaminidase ^²

Descriptions
N-acetylglucosaminidase, alpha- ^²

External Ids
HGNC: 7632¹
Entrez Gene: 4669²
UniProtKB: P54802³
Ensembl: ENSG00000108784⁷

Search outside databases for aliases for NAGLU gene

Previous GC identifers: GC17M040212 GC17M042827 GC17P040596 GC17P041061

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAGLU:

This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal

N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the

cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This

disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ANAG_HUMAN, P54802

Function: Involved in the degradation of heparan sulfate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAGLU gene

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q11-q21

NAGLU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P037941: (about GC identifiers)

Start:	37,941,477 bp from pter
End:	37,949,993 bp from pter
Size:	8,517 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ANAG_HUMAN, P54802 (See protein sequence)

Recommended Name: Alpha-N-acetylglucosaminidase precursor

Size: 743 amino acids; 82167 Da

Subunit: Monomer and homodimer

Caution: A MPS3B mutation at position 100 was erroneously reported (PubMed:9950362) as an amino

acid change from Arg to His. The right amino acid change is from His to Arg

REFSEQ proteins: NP_000254.2

ENSEMBL proteins:

ENSP00000366622 ENSP00000225927

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NAGLU)
	Human Recombinant Proteins from Abnova (NAGLU)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	TAS	8650226

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Antibodies for NAGLU:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NAGLU
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NAGLU), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NAGLU)
	Novus Biologicals Antibodies for NAGLU

Assays for NAGLU:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P54802

ProtoNet protein and cluster: P54802

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAGLU)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAGLU)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000263

Applied Biosystems Silencer® siRNAs for NAGLU

Sigma-Aldrich siRNA and siRNA Panels for NAGLU

Sigma-Aldrich shRNA for NAGLU

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAGLU
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000263
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000263
untagged cDNA clone in CMV expression vector: NM_000263

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000263

UniProtKB/Swiss-Prot: ANAG_HUMAN, P54802

Function: Involved in the degradation of heparan sulfate

Catalytic activity: Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in

N-acetyl-alpha-D-glucosaminides

Enzyme Number (IUBMB): EC 3.2.1.50

Genatlas biochemistry entry for NAGLU:

acetyl-glucosaminidase,alpha-N,77/82kDa,lysosomal,acting on heparan sulfate,catalyzing the fifth

step of degradation of glycosaminoglycans (mucopolysaccharides)

15 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Naglu):

behavior/neurological	cellular	craniofacial	growth/size	hearing/vestibular/ear
hematopoietic system	immune system	life span-post-weaning/aging	liver/biliary system	nervous system
pigmentation	renal/urinary system	skeleton	skin/coat/nails	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004561	alpha-N-acetylglucosaminidase activity	TAS	8650226
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for NAGLU (Your Favorite Gene powered by Ingenuity)

Glycosaminoglycan Degradation
Inositol Metabolism

GeneDecks NAGLU for the pathways selected above

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5/16 Interacting proteins for NAGLU (ENSP00000225927³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SGSH	ENSP00000314606³	STRING (score=.921)
GUSB	ENSP00000302728³	STRING (score=.877)
CTSD	ENSP00000236671³	STRING (score=.868)
NAGA	ENSP00000355349³	STRING (score=.8)
B2M	ENSP00000340858³	STRING (score=.794)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	TAS	8650226
GO:0008152	metabolic process	IEA	--
GO:0030203	glycosaminoglycan metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for NAGLU available from Tocris Bioscience

Compound	Action	CAS number
(Z)-Pugnac	O-GlcNAcase and beta-hexosaminidase inhibitor	[132489-69-1]

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10/61 Novoseek chemical compound relationships for NAGLU gene (see all 61 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
vra-glcnac	89.18	1	1610104 (1)
cadmium	61.51	119	2403983 (5), 1463395 (4), 9037804 (4), 1587629 (4) (see all 35)
heparan sulfate	53.46	19	10588735 (2), 10094189 (1), 11136549 (1), 11578848 (1) (see all 14)
uric acid	43.33	28	18063857 (5), 11847525 (3), 15626645 (3), 7768579 (2) (see all 12)
mercury	41.27	20	14653309 (4), 7753757 (3), 18684440 (2), 15130443 (2) (see all 9)
lead	40.82	41	8141178 (4), 17497640 (4), 9037804 (3), 2391405 (3) (see all 14)
inulin	39.65	5	1988713 (1), 8675159 (1), 15769882 (1), 1583405 (1) (see all 5)
sodium	39.62	29	11847525 (2), 1678405 (2), 9002297 (2), 15565439 (1) (see all 21)
malondialdehyde	36.15	20	15565439 (3), 14665375 (2), 16538044 (2), 17541572 (1) (see all 7)
1,3-dichloropropene	34.95	4	8243412 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAGLU)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAGLU)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000263

Sigma-Aldrich siRNA and siRNA Panels for NAGLU

Sigma-Aldrich shRNA for NAGLU

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000263

REFSEQ mRNAs for NAGLU gene:

NM_000263.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000263

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000263
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000263
                                 untagged cDNA clone in CMV expression vector: NM_000263

Additional cDNA sequence:

BC053991.1 CR623854.1 L78464.1 U40846.1 U43573.1

11 DOTS entries:

DT.120973669 DT.413876 DT.100749425 DT.97817493 DT.75184455 DT.100749424 DT.100749426 DT.120973622

DT.120973645 DT.120973709 DT.95368263

24/163 AceView cDNA sequences (see all 163 ):

BM710066 BQ012348 BM773017 BF346260 AU279934 NM_000263 CR623854 L78464

AW205580 BF435029 BM752987 BM716556 BM746456 AU118592 BQ893829 CB268477

BQ012843 BC053991 U43573 BM711369 AI973061 BM772104 AI417417 BM745799

highest scoring ESTs for NAGLU:

U43573 BQ683563 BQ935423 CB153101 AA613718 AB209530 AI299657 AI758095 BM989126 T98509

Unigene Cluster for NAGLU:

N-acetylglucosaminidase, alpha-

Hs.50727 [show with all ESTs]

Unigene Representative Sequence: NM_000263

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NAGLU

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:
SP2:
SP3:															-

About this scheme

ECgene alternative splicing isoforms for NAGLU

2 Ensembl transcripts including schematic representations:

ENST00000377405 ENST00000225927

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NAGLU expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAGLU

¹ / ² / ³

3 probe-sets matching NAGLU gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41596_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U43573	0.80	0.80	0.80	1
204360_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000263	0.40	0.67	0.55	1
204360_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAGLU for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGAGCTGG

SOURCE GeneReport for Unigene cluster: Hs.50727
Expression variation in blood from EXPOLDB for NAGLU
UniProtKB/Swiss-Prot: ANAG_HUMAN, P54802
Tissue specificity: Liver, ovary, peripheral blood leukocytes, testis, prostrate, spleen, colon,
lung, placenta and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NAGLU gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAGLU¹	--	N-acetylglucosaminidase, alpha-	87.02(n) 85.85(a)	490965 XM_548088.2 XP_548088.2
chimpanzee (Pan troglodytes)	NAGLU¹	--	N-acetylglucosaminidase, alpha-	99.69(n) 99.87(a)	468265 XM_523654.2 XP_523654.2
cow (Bos taurus)	NAGLU¹	--	alpha-N-acetylglucosaminidase	85.66(n) 86.06(a)	789125 XM_001255546.1 XP_001255547.1
mouse (Mus musculus)	Naglu^{1, 5}	11⁵	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)^{1, 5}	83.76(n)¹ 83.13(a)¹	27419¹ NM_013792.1¹ NP_038820.1¹ AF003255⁵ AF363242⁵ (see all 35)
chicken (Gallus gallus)	NAGLU¹	--	N-acetylglucosaminidase, alpha- (Sanfilippo disease more	69.06(n) 65.91(a)	771195 XM_001234487.1 XP_001234488.1

About this table Species with no ortholog for NAGLU

ENSEMBL Gene Tree for NAGLU

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/61 NCBI SNPs in NAGLU are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs86312^1,2	A,C,F,H	37949759(+)	`ACCCCG/CGCTGG`	1	G/R	mis¹		13		MN EU EA WA NA	1232
	rs1048178^1,2	C,F	37949945(+)	`CCTCCA/CCCACC`	1	--	ut3¹ ese³		1		MN	184
	rs9899823^1,2	F,H	37939605(+)	`TGGCAT/CTTAGA`	1	--	ng5¹		4		EU EA WA	418
--	rs683344^1,2	A,C	37950276(+)	`accacA/Gccagg`	1	--	ng3¹		0	--	--	--	--
--	rs4793099^1,2	A,C	37939566(-)	`TTTCTA/GCTGAA`	1	--	ng5¹		0	--	--	--	--
--	rs4793090^1,2	C	37939868(-)	`tgtctC/Tagtct`	1	--	ng5¹		0	--	--	--	--
--	rs1048183^1,2	F	37949948(+)	`CCACCA/CCCACC`	1	--	ut3¹ ese³		1		MN	93
	rs659497^1,2	C,F,H	37942981(+)	`TACTCC/TTTCGT`	1	S/S	syn¹		9		EA NA MN EU WA	766
	rs630539^1,2	C,F,H	37946870(+)	`TACTTT/CATAGT`	1	--	int¹		5		MN EU EA WA	602
	rs2071046^1,2	C,F,H	37943139(+)	`CCACCC/GTAGGT`	1	--	int¹		5		EA EU WA	1864

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HapMap Linkage Disequilibrium images for NAGLU (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 609701 disorders: 252920

UniProtKB/Swiss-Prot: ANAG_HUMAN, P54802

Defects in NAGLU are the cause of mucopolysaccharidosis type 3B (MPS3B) [MIM:252920]; also

known as Sanfilippo syndrome B. MPS3B is a form of mucopolysaccharidosis type 3, an autosomal

recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is

characterized by severe central nervous system degeneration, but only mild somatic disease. Onset

of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs

in most patients between 6 and 10 years of age, and death occurs typically during the second or

third decade of life

10/93 Novoseek disease relationships for NAGLU gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sanfilippos syndrome	89.25	24	10588735 (3), 9443878 (2), 19399896 (2), 9443875 (1) (see all 17)
mps iii b	86.02	3	11136549 (1), 16401642 (1), 19399896 (1)
mucopolysaccharidosis	77.71	20	11068184 (2), 9443875 (1), 10094189 (1), 11237686 (1) (see all 14)
microalbuminuria	74.72	44	9612904 (4), 15330557 (4), 12368574 (4), 2150050 (2) (see all 27)
proteinuria	74.40	68	12401843 (6), 15503426 (4), 15714179 (4), 12900807 (4) (see all 37)
albuminuria	72.44	19	1837508 (2), 8998811 (2), 1533771 (2), 9861409 (2) (see all 14)
renal disease	72.38	56	1962647 (4), 8739282 (3), 2342652 (3), 2150050 (2) (see all 40)
diabetic nephropathies	68.80	33	1350771 (5), 1685160 (2), 7669872 (2), 9436372 (2) (see all 18)
mps iiia	65.06	1	11793481 (1)
toxicity renal	61.17	2	9061418 (1), 17306939 (1)

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Human Gene Mutation Database: NAGLU

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/553 PubMed articles for NAGLU gene (see all 553 ):

Mucopolysaccharidosis type IIIB: characterisation and expression of wild-type and mutant recombinant alpha-N-acetylglucosaminidase and relationship with sanfilippo phenotype in an attenuated patient. (PubMed id 11068184)^{1, 3, 4} Yogalingam G.... Hopwood J.J. (2000)
NAGLU mutations underlying Sanfilippo syndrome type B. (PubMed id 9443878)^{1, 3, 4} Schmidtchen A....Neufeld E.F. (1998)
Sanfilippo type B syndrome: five patients with an R565P homozygous mutation in the alpha-N-acetylglucosaminidase gene from the Okinawa islands in Japan. (PubMed id 15933803)^{1, 3, 4} Chinen Y.... Ohta T. (2005)
Sanfilippo syndrome in Turkey: Identification of novel mutations in subtypes A and B. (PubMed id 11793481)^{1, 3, 4} Emre S....Hopwood J.J. (2002)
Sanfilippo type B syndrome (mucopolysaccharidosis III B): allelic heterogeneity corresponds to the wide spectrum of clinical phenotypes. (PubMed id 10094189)^{1, 3, 4} Weber B.... Hopwood J.J. (1999)
The molecular basis of Sanfilippo syndrome type B. (PubMed id 8650226)^{1, 3, 4} Zhao H.G.... Neufeld E.F. (1996)
Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B). (PubMed id 8776591)^{1, 3, 4} Weber B.... Hopwood J.J. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular analysis of the alpha-N-acetylglucosaminidase gene in seven Japanese patients from six unrelated families with mucopolysaccharidosis IIIB (Sanfilippo type B), including two novel mutations. (PubMed id 12202988)^{3, 4} Tanaka A.... Yamano T. (2002)
Mucopolysaccharidosis type IIIB (Sanfilippo B): identification of 18 novel alpha-N-acetylglucosaminidase gene mutations. (PubMed id 9950362)^{3, 4} Bunge S.... Gal A. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4669	HGNC: 7632	AceView: NAGLU	Ensembl:ENSG00000108784	euGenes: HUgn4669
ECgene: NAGLU	H-InvDB: NAGLU

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=NAGLU

Licensable Technologies for NAGLU
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NAGLU:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAGLU-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAGLU		Antibodies for NAGLU
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAGLU		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAGLU)
	Antibodies (NAGLU)
	Chimera RNAi (NAGLU)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (NAGLU)
	Antibodies (NAGLU)

Search OriGene for NAGLU

Tocris compounds for NAGLU

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NAGLU

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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NAGLU Gene at Home site.
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NAGLU Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for NAGLU

Summaries
for NAGLU

Genomic Location
for NAGLU

Proteins
for NAGLU

Protein Domains/
Families
for NAGLU

Gene Function
for NAGLU

Pathways & Interactions
for NAGLU

Drugs & Compounds
for NAGLU

Transcripts
for NAGLU

Expression
for NAGLU

Orthologs
for NAGLU

Paralogs
for NAGLU

SNPs/Variants
for NAGLU

Disorders & Mutations
for NAGLU

Medical News
for NAGLU

Publications
for NAGLU

Search for NAGLU

Genome Databases showing NAGLU

Other Databases showing NAGLU

Specialized Databases showing NAGLU

Licensable Technologies
for NAGLU

Services
for NAGLU

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAGLU Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor NAGLU

Summariesfor NAGLU

Genomic Locationfor NAGLU

Proteinsfor NAGLU

Protein Domains/Familiesfor NAGLU

Gene Functionfor NAGLU

Pathways & Interactionsfor NAGLU

Drugs & Compoundsfor NAGLU

Transcriptsfor NAGLU

Expression for NAGLU

Orthologsfor NAGLU

Paralogsfor NAGLU

SNPs/Variantsfor NAGLU

Disorders & Mutationsfor NAGLU

Medical Newsfor NAGLU

Publicationsfor NAGLU

Search for NAGLU

Genome Databases showing NAGLU

Other Databases showing NAGLU

Specialized Databases showing NAGLU

Licensable Technologiesfor NAGLU

Servicesfor NAGLU

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAGLU

Summaries
for NAGLU

Genomic Location
for NAGLU

Proteins
for NAGLU

Protein Domains/
Families
for NAGLU

Gene Function
for NAGLU

Pathways & Interactions
for NAGLU

Drugs & Compounds
for NAGLU

Transcripts
for NAGLU

Expression
for NAGLU

Orthologs
for NAGLU

Paralogs
for NAGLU

SNPs/Variants
for NAGLU

Disorders & Mutations
for NAGLU

Medical News
for NAGLU

Publications
for NAGLU

Licensable Technologies
for NAGLU

Services
for NAGLU