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Aliases for NAGK Gene

Aliases for NAGK Gene

  • N-Acetylglucosamine Kinase 2 3 4
  • GlcNAc Kinase 3 4
  • EC 2.7.1.59 4 64
  • GNK 3 6
  • N-Acetyl-D-Glucosamine Kinase 3
  • HSA242910 3

External Ids for NAGK Gene

Summaries for NAGK Gene

Entrez Gene Summary for NAGK Gene

  • This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

GeneCards Summary for NAGK Gene

NAGK (N-Acetylglucosamine Kinase) is a Protein Coding gene. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include N-acylmannosamine kinase activity and N-acetylglucosamine kinase activity.

UniProtKB/Swiss-Prot for NAGK Gene

  • Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.

Gene Wiki entry for NAGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAGK Gene

Genomics for NAGK Gene

Genomic Location for NAGK Gene

Start:
71,064,344 bp from pter
End:
71,079,805 bp from pter
Size:
15,462 bases
Orientation:
Plus strand

Genomic View for NAGK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAGK Gene

Regulatory Elements for NAGK Gene

Proteins for NAGK Gene

  • Protein details for NAGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ70-NAGK_HUMAN
    Recommended name:
    N-acetyl-D-glucosamine kinase
    Protein Accession:
    Q9UJ70
    Secondary Accessions:
    • B4DLZ5
    • Q53HD5
    • Q6IA84
    • Q9BS29
    • Q9BVP0
    • Q9NV37

    Protein attributes for NAGK Gene

    Size:
    344 amino acids
    Molecular mass:
    37376 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for NAGK Gene

    Alternative splice isoforms for NAGK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAGK Gene

Proteomics data for NAGK Gene at MOPED

Selected DME Specific Peptides for NAGK Gene

Post-translational modifications for NAGK Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys59

Domains for NAGK Gene

Protein Domains for NAGK Gene

UniProtKB/Swiss-Prot:

NAGK_HUMAN
Family:
  • Belongs to the eukaryotic-type N-acetylglucosamine kinase family.:
    • Q9UJ70
genes like me logo Genes that share domains with NAGK: view

No data available for Gene Families for NAGK Gene

Function for NAGK Gene

Molecular function for NAGK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.
UniProtKB/Swiss-Prot Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.

Enzyme Numbers (IUBMB) for NAGK Gene

Gene Ontology (GO) - Molecular Function for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0009384 N-acylmannosamine kinase activity IEA --
GO:0045127 N-acetylglucosamine kinase activity IDA 22692205
genes like me logo Genes that share ontologies with NAGK: view

Phenotypes for NAGK Gene

genes like me logo Genes that share phenotypes with NAGK: view

miRNA for NAGK Gene

miRTarBase miRNAs that target NAGK

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NAGK Gene

Localization for NAGK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAGK Gene COMPARTMENTS Subcellular localization image for NAGK gene
Compartment Confidence
cytoskeleton 3
chloroplast 1
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAGK: view

Pathways for NAGK Gene

genes like me logo Genes that share pathways with NAGK: view

Pathways by source for NAGK Gene

1 BioSystems pathway for NAGK Gene
1 KEGG pathway for NAGK Gene

UniProtKB/Swiss-Prot Q9UJ70-NAGK_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation.

Gene Ontology (GO) - Biological Process for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IEA --
GO:0006051 N-acetylmannosamine metabolic process TAS 10824116
GO:0019262 N-acetylneuraminate catabolic process TAS 22692205
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with NAGK: view

Compounds for NAGK Gene

(5) HMDB Compounds for NAGK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Chitin
  • Poly 2-Acetamido-2-deoxy-D-glucose
1398-61-4
N-Acetyl-D-glucosamine
  • 2-(acetylamino)-2-deoxyhexose
7512-17-6
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
102029-88-9

(1) Drugbank Compounds for NAGK Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-Acetyl-D-glucosamine
  • 2-Acetamido-2-deoxy-D-glucose
7512-17-6 target

(9) Novoseek inferred chemical compound relationships for NAGK Gene

Compound -log(P) Hits PubMed IDs
n-acetylglutamate 91.9 8
n-acetylglucosamine 85.5 26
carbamoyl phosphate 61.5 1
sialic acid 54 1
atp 42.9 5
genes like me logo Genes that share compounds with NAGK: view

Transcripts for NAGK Gene

Unigene Clusters for NAGK Gene

N-acetylglucosamine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAGK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - - - - - -
SP13:
SP14: - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - -
SP17:
SP18: - - -

ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - -
SP13: - -
SP14:
SP15: - -
SP16: - -
SP17:
SP18:

Relevant External Links for NAGK Gene

GeneLoc Exon Structure for
NAGK
ECgene alternative splicing isoforms for
NAGK

Expression for NAGK Gene

mRNA expression in normal human tissues for NAGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAGK Gene

This gene is overexpressed in Whole Blood (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAGK Gene

SOURCE GeneReport for Unigene cluster for NAGK Gene Hs.7036

mRNA Expression by UniProt/SwissProt for NAGK Gene

Q9UJ70-NAGK_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with NAGK: view

Orthologs for NAGK Gene

This gene was present in the common ancestor of animals.

Orthologs for NAGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAGK 36
  • 99.31 (n)
  • 99.23 (a)
NAGK 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAGK 36
  • 91.28 (n)
  • 93.02 (a)
NAGK 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAGK 36
  • 90.41 (n)
  • 91.57 (a)
NAGK 37
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nagk 36
  • 87.27 (n)
  • 91.84 (a)
Nagk 16
Nagk 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAGK 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAGK 37
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nagk 36
  • 87.66 (n)
  • 92.42 (a)
lizard
(Anolis carolinensis)
Reptilia NAGK 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485993 36
  • 68.12 (n)
  • 65.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10678 36
zebrafish
(Danio rerio)
Actinopterygii NAGK 37
  • 62 (a)
OneToOne
zgc:171682 36
  • 63.21 (n)
  • 63.21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000241 36
  • 53.43 (n)
  • 43.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6218 36
  • 51.86 (n)
  • 45.92 (a)
CG6218 37
  • 43 (a)
OneToOne
CG6218 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea W06B4.2 36
  • 43.72 (n)
  • 33.44 (a)
W06B4.2 37
  • 20 (a)
OneToOne
W06B4.2 38
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12788 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToOne
Species with no ortholog for NAGK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAGK Gene

ENSEMBL:
Gene Tree for NAGK (if available)
TreeFam:
Gene Tree for NAGK (if available)

Paralogs for NAGK Gene

Pseudogenes.org Pseudogenes for NAGK Gene

genes like me logo Genes that share paralogs with NAGK: view

No data available for Paralogs for NAGK Gene

Variants for NAGK Gene

Sequence variations from dbSNP and Humsavar for NAGK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6713 -- 71,078,326(-) CGCCA(A/G)AAGAA reference, synonymous-codon
rs888352 -- 71,069,927(-) CCTTT(A/G)CTAGA intron-variant
rs999240 -- 71,070,398(-) AGACA(A/G)CTTCG intron-variant
rs1043685 -- 71,072,711(+) AGTGG(A/C/G/T)AGCGG frameshift-variant, reference, utr-variant-5-prime
rs1043701 -- 71,077,608(+) TCTGT(A/G)TGGAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for NAGK Gene

Variant ID Type Subtype PubMed ID
nsv874253 CNV Gain 21882294
nsv834256 CNV Gain 17160897
nsv524446 CNV Loss 19592680
esv32639 CNV Gain 17666407

Relevant External Links for NAGK Gene

HapMap Linkage Disequilibrium report
NAGK

Disorders for NAGK Gene

No disorders were found for NAGK Gene.

No data available for UniProtKB/Swiss-Prot for NAGK Gene

Publications for NAGK Gene

  1. Molecular cloning and characterization of murine and human N- acetylglucosamine kinase. (PMID: 10824116) Hinderlich S. … Reutter W. (Eur. J. Biochem. 2000) 2 3 4 23
  2. Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. (PMID: 17010375) Weihofen W.A. … Hinderlich S. (J. Mol. Biol. 2006) 3 4 23 25
  3. N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. (PMID: 8982040) Weidanz J.A. … Vezza A.C. (Br. J. Haematol. 1996) 3 23
  4. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PMID: 9468341) Lowes W. … Agius L. (Biochim. Biophys. Acta 1998) 3 23
  5. Identification of the phosphotyrosine proteome from thrombin activated platelets. (PMID: 12112843) Maguire P.B. … Fitzgerald D.J. (Proteomics 2002) 3 4

Products for NAGK Gene

  • Addgene plasmids for NAGK

Sources for NAGK Gene

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