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Aliases for NAGK Gene

Aliases for NAGK Gene

  • N-Acetylglucosamine Kinase 2 3 4
  • GlcNAc Kinase 3 4
  • EC 2.7.1.59 4 63
  • HSA242910 3
  • GNK 3

External Ids for NAGK Gene

Previous GeneCards Identifiers for NAGK Gene

  • GC02P071305
  • GC02P071506
  • GC02P071270
  • GC02P071207
  • GC02P071148
  • GC02P071295
  • GC02P071031

Summaries for NAGK Gene

Entrez Gene Summary for NAGK Gene

  • This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

GeneCards Summary for NAGK Gene

NAGK (N-Acetylglucosamine Kinase) is a Protein Coding gene. Among its related pathways are Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include N-acylmannosamine kinase activity and N-acetylglucosamine kinase activity.

UniProtKB/Swiss-Prot for NAGK Gene

  • Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.

Gene Wiki entry for NAGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAGK Gene

Genomics for NAGK Gene

Regulatory Elements for NAGK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAGK Gene

Chromosome:
2
Start:
71,064,344 bp from pter
End:
71,079,805 bp from pter
Size:
15,462 bases
Orientation:
Plus strand

Genomic View for NAGK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAGK Gene

Proteins for NAGK Gene

  • Protein details for NAGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ70-NAGK_HUMAN
    Recommended name:
    N-acetyl-D-glucosamine kinase
    Protein Accession:
    Q9UJ70
    Secondary Accessions:
    • B4DLZ5
    • Q53HD5
    • Q6IA84
    • Q9BS29
    • Q9BVP0
    • Q9NV37

    Protein attributes for NAGK Gene

    Size:
    344 amino acids
    Molecular mass:
    37376 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for NAGK Gene

    Alternative splice isoforms for NAGK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAGK Gene

Proteomics data for NAGK Gene at MOPED

Selected DME Specific Peptides for NAGK Gene

Post-translational modifications for NAGK Gene

  • Ubiquitination at Lys 59
  • Modification sites at PhosphoSitePlus

Domains & Families for NAGK Gene

Protein Domains for NAGK Gene

Suggested Antigen Peptide Sequences for NAGK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJ70

UniProtKB/Swiss-Prot:

NAGK_HUMAN :
  • Belongs to the eukaryotic-type N-acetylglucosamine kinase family.
Family:
  • Belongs to the eukaryotic-type N-acetylglucosamine kinase family.
genes like me logo Genes that share domains with NAGK: view

No data available for Gene Families for NAGK Gene

Function for NAGK Gene

Molecular function for NAGK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.
UniProtKB/Swiss-Prot Function:
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.

Enzyme Numbers (IUBMB) for NAGK Gene

Gene Ontology (GO) - Molecular Function for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0009384 N-acylmannosamine kinase activity IEA --
GO:0045127 N-acetylglucosamine kinase activity IDA 22692205
genes like me logo Genes that share ontologies with NAGK: view
genes like me logo Genes that share phenotypes with NAGK: view

Animal Model Products

miRNA for NAGK Gene

miRTarBase miRNAs that target NAGK

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAGK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NAGK Gene

Localization for NAGK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAGK Gene COMPARTMENTS Subcellular localization image for NAGK gene
Compartment Confidence
extracellular 5
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAGK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAGK Gene

Pathways & Interactions for NAGK Gene

genes like me logo Genes that share pathways with NAGK: view

Pathways by source for NAGK Gene

1 BioSystems pathway for NAGK Gene
1 KEGG pathway for NAGK Gene

UniProtKB/Swiss-Prot Q9UJ70-NAGK_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation.

Gene Ontology (GO) - Biological Process for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IEA --
GO:0006051 N-acetylmannosamine metabolic process TAS 10824116
GO:0019262 N-acetylneuraminate catabolic process TAS 22692205
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with NAGK: view

No data available for SIGNOR curated interactions for NAGK Gene

Drugs & Compounds for NAGK Gene

(5) Drugs for NAGK Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra Target 0
Adenosine triphosphate Approved Nutra 0
Chitin Nutra 5
ATP Pharma Activator 0
arginine Nutra 346

(8) Additional Compounds for NAGK Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
102029-88-9
Carbamoyl phosphate
  • Carbamic acid monoanhydride with phosphorate
  • Carbamic acid monoanhydride with phosphoric acid
  • Carbamoyl-P
  • Carbamoyl-phosphate
  • Carbamoylphosphate
590-55-6
glucose
mannose
genes like me logo Genes that share compounds with NAGK: view

Transcripts for NAGK Gene

Unigene Clusters for NAGK Gene

N-acetylglucosamine kinase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAGK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAGK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - - - - - -
SP13:
SP14: - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - -
SP17:
SP18: - - -

ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - -
SP13: - -
SP14:
SP15: - -
SP16: - -
SP17:
SP18:

Relevant External Links for NAGK Gene

GeneLoc Exon Structure for
NAGK
ECgene alternative splicing isoforms for
NAGK

Expression for NAGK Gene

mRNA expression in normal human tissues for NAGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAGK Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for NAGK Gene

This gene is overexpressed in Lymph node (10.4) and Spleen (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAGK Gene



SOURCE GeneReport for Unigene cluster for NAGK Gene Hs.7036

mRNA Expression by UniProt/SwissProt for NAGK Gene

Q9UJ70-NAGK_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NAGK: view

Protein tissue co-expression partners for NAGK Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NAGK Gene

This gene was present in the common ancestor of animals.

Orthologs for NAGK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAGK 35
  • 91.28 (n)
  • 93.02 (a)
NAGK 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAGK 35
  • 90.41 (n)
  • 91.57 (a)
NAGK 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nagk 35
  • 87.27 (n)
  • 91.84 (a)
Nagk 16
Nagk 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAGK 35
  • 99.31 (n)
  • 99.23 (a)
NAGK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nagk 35
  • 87.66 (n)
  • 92.42 (a)
oppossum
(Monodelphis domestica)
Mammalia NAGK 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAGK 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAGK 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485993 35
  • 68.12 (n)
  • 65.7 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:171682 35
  • 63.21 (n)
  • 63.21 (a)
NAGK 36
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10678 35
fruit fly
(Drosophila melanogaster)
Insecta CG6218 37
  • 44 (a)
CG6218 35
  • 51.86 (n)
  • 45.92 (a)
CG6218 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000241 35
  • 53.43 (n)
  • 43.94 (a)
worm
(Caenorhabditis elegans)
Secernentea W06B4.2 37
  • 32 (a)
W06B4.2 35
  • 43.72 (n)
  • 33.44 (a)
W06B4.2 36
  • 20 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12788 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for NAGK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAGK Gene

ENSEMBL:
Gene Tree for NAGK (if available)
TreeFam:
Gene Tree for NAGK (if available)

Paralogs for NAGK Gene

Pseudogenes.org Pseudogenes for NAGK Gene

genes like me logo Genes that share paralogs with NAGK: view

No data available for Paralogs for NAGK Gene

Variants for NAGK Gene

Sequence variations from dbSNP and Humsavar for NAGK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6713 -- 71,078,326(-) CGCCA(A/G)AAGAA reference, synonymous-codon, nc-transcript-variant
rs888352 -- 71,069,927(-) CCTTT(A/G)CTAGA intron-variant
rs999240 -- 71,070,398(-) AGACA(A/G)CTTCG intron-variant
rs1043685 -- 71,072,711(+) AGTGG(A/C/G/T)AGCGG frameshift-variant, reference, nc-transcript-variant
rs1043701 -- 71,077,608(+) TCTGT(A/G)TGGAA synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NAGK Gene

Variant ID Type Subtype PubMed ID
nsv874253 CNV Gain 21882294
nsv834256 CNV Gain 17160897
nsv524446 CNV Loss 19592680
esv32639 CNV Gain 17666407

Variation tolerance for NAGK Gene

Residual Variation Intolerance Score: 54.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAGK Gene

HapMap Linkage Disequilibrium report
NAGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAGK Gene

Disorders for NAGK Gene

Relevant External Links for NAGK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAGK
genes like me logo Genes that share disorders with NAGK: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAGK Gene

Publications for NAGK Gene

  1. Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii. (PMID: 17229727) Nishimasu H. … Wakagi T. (J. Biol. Chem. 2007) 23 25 26 67
  2. Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. (PMID: 17010375) Weihofen W.A. … Hinderlich S. (J. Mol. Biol. 2006) 23 25 26 67
  3. Comparative proteomics of ovarian epithelial tumors. (PMID: 16674097) An H.J. … Cho N.H. (J. Proteome Res. 2006) 23 25 26 67
  4. Molecular cloning and characterization of murine and human N- acetylglucosamine kinase. (PMID: 10824116) Hinderlich S. … Reutter W. (Eur. J. Biochem. 2000) 2 23 67
  5. On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm. (PMID: 20386738) Marcos E. … Bahar I. (PLoS Comput. Biol. 2010) 23 67

Products for NAGK Gene

Sources for NAGK Gene

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