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Aliases for NAGK Gene

Aliases for NAGK Gene

  • N-Acetylglucosamine Kinase 2 3 4 5
  • GlcNAc Kinase 3 4
  • EC 2.7.1.59 4 61
  • N-Acetyl-D-Glucosamine Kinase 3
  • HSA242910 3
  • GNK 3

External Ids for NAGK Gene

Previous GeneCards Identifiers for NAGK Gene

  • GC02P071305
  • GC02P071506
  • GC02P071270
  • GC02P071207
  • GC02P071148
  • GC02P071295
  • GC02P071031

Summaries for NAGK Gene

Entrez Gene Summary for NAGK Gene

  • This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

GeneCards Summary for NAGK Gene

NAGK (N-Acetylglucosamine Kinase) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include N-acylmannosamine kinase activity and N-acetylglucosamine kinase activity.

UniProtKB/Swiss-Prot for NAGK Gene

  • Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.

Gene Wiki entry for NAGK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAGK Gene

Genomics for NAGK Gene

Regulatory Elements for NAGK Gene

Enhancers for NAGK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G071062 1.7 Ensembl ENCODE dbSUPER 42.9 +4.3 4261 11.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC NAGK MPHOSPH10 OR7E62P ENSG00000272735 GC02P071073
GH02G071047 1 ENCODE 36.3 -15.4 -15403 2.8 HDGF ARID4B SIN3A ZNF48 ZNF2 SLC30A9 ZNF121 GLIS2 ZNF143 FOS NAGK OR7E62P ATP6V1B1-AS1 TRE-CTC15-1
GH02G070107 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -953.5 -953495 7.3 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PCBP1-AS1 C2orf42 FAM136A GMCL1 ANKRD53 LOC105374796 NAGK SNRNP27 MXD1 PCYOX1
GH02G071128 1.4 ENCODE dbSUPER 13 +66.4 66361 4.4 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 MPHOSPH10 TEX261 NAGK ANKRD53 MCEE LOC101060051
GH02G070080 1.4 ENCODE dbSUPER 10.5 -978.0 -977953 11.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PCBP1-AS1 C2orf42 GMCL1 MXD1 SNRNP27 NAGK PCYOX1 PCBP1 RN7SL470P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAGK on UCSC Golden Path with GeneCards custom track

Genomic Location for NAGK Gene

Chromosome:
2
Start:
71,064,344 bp from pter
End:
71,079,805 bp from pter
Size:
15,462 bases
Orientation:
Plus strand

Genomic View for NAGK Gene

Genes around NAGK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAGK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAGK Gene

Proteins for NAGK Gene

  • Protein details for NAGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ70-NAGK_HUMAN
    Recommended name:
    N-acetyl-D-glucosamine kinase
    Protein Accession:
    Q9UJ70
    Secondary Accessions:
    • B4DLZ5
    • Q53HD5
    • Q6IA84
    • Q9BS29
    • Q9BVP0
    • Q9NV37

    Protein attributes for NAGK Gene

    Size:
    344 amino acids
    Molecular mass:
    37376 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for NAGK Gene

    Alternative splice isoforms for NAGK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAGK Gene

Selected DME Specific Peptides for NAGK Gene

Q9UJ70:
  • YGGVEGGGTRS
  • KLRHSSALG
  • VAVLPEIDPVLFQG

Post-translational modifications for NAGK Gene

  • Ubiquitination at posLast=5959
  • Modification sites at PhosphoSitePlus

Domains & Families for NAGK Gene

Protein Domains for NAGK Gene

Suggested Antigen Peptide Sequences for NAGK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJ70

UniProtKB/Swiss-Prot:

NAGK_HUMAN :
  • Belongs to the eukaryotic-type N-acetylglucosamine kinase family.
Family:
  • Belongs to the eukaryotic-type N-acetylglucosamine kinase family.
genes like me logo Genes that share domains with NAGK: view

No data available for Gene Families for NAGK Gene

Function for NAGK Gene

Molecular function for NAGK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.
UniProtKB/Swiss-Prot Function:
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.

Enzyme Numbers (IUBMB) for NAGK Gene

Gene Ontology (GO) - Molecular Function for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0009384 N-acylmannosamine kinase activity IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NAGK: view
genes like me logo Genes that share phenotypes with NAGK: view

Animal Models for NAGK Gene

MGI Knock Outs for NAGK:
  • Nagk tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for NAGK

miRNA for NAGK Gene

miRTarBase miRNAs that target NAGK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NAGK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAGK Gene

Localization for NAGK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAGK gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAGK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAGK Gene

Pathways & Interactions for NAGK Gene

genes like me logo Genes that share pathways with NAGK: view

UniProtKB/Swiss-Prot Q9UJ70-NAGK_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation.

Gene Ontology (GO) - Biological Process for NAGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process TAS 10824116
GO:0006048 UDP-N-acetylglucosamine biosynthetic process TAS --
GO:0006051 N-acetylmannosamine metabolic process TAS 10824116
GO:0016310 phosphorylation IEA --
GO:0019262 N-acetylneuraminate catabolic process TAS 22692205
genes like me logo Genes that share ontologies with NAGK: view

No data available for SIGNOR curated interactions for NAGK Gene

Drugs & Compounds for NAGK Gene

(6) Drugs for NAGK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra Target 0
Adenosine triphosphate Approved Nutra 0
Chitin Nutra 6

(7) Additional Compounds for NAGK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
102029-88-9
genes like me logo Genes that share compounds with NAGK: view

Transcripts for NAGK Gene

Unigene Clusters for NAGK Gene

N-acetylglucosamine kinase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NAGK

Alternative Splicing Database (ASD) splice patterns (SP) for NAGK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - - - - - -
SP13:
SP14: - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - -
SP17:
SP18: - - -

ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - -
SP13: - -
SP14:
SP15: - -
SP16: - -
SP17:
SP18:

Relevant External Links for NAGK Gene

GeneLoc Exon Structure for
NAGK
ECgene alternative splicing isoforms for
NAGK

Expression for NAGK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAGK Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for NAGK Gene

This gene is overexpressed in Lymph node (10.4) and Spleen (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAGK Gene



Protein tissue co-expression partners for NAGK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAGK Gene:

NAGK

SOURCE GeneReport for Unigene cluster for NAGK Gene:

Hs.7036

mRNA Expression by UniProt/SwissProt for NAGK Gene:

Q9UJ70-NAGK_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for NAGK Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Skin(4.4)
  • Blood(4.3)
  • Kidney(4.3)
  • Lymph node(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with NAGK: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAGK Gene

Orthologs for NAGK Gene

This gene was present in the common ancestor of animals.

Orthologs for NAGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAGK 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia NAGK 34 35
  • 91.28 (n)
dog
(Canis familiaris)
Mammalia NAGK 34 35
  • 90.41 (n)
rat
(Rattus norvegicus)
Mammalia Nagk 34
  • 87.66 (n)
mouse
(Mus musculus)
Mammalia Nagk 34 16 35
  • 87.27 (n)
oppossum
(Monodelphis domestica)
Mammalia NAGK 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAGK 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAGK 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485993 34
  • 68.12 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171682 34
  • 63.21 (n)
NAGK 35
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10678 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000241 34
  • 53.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6218 36 34 35
  • 51.86 (n)
worm
(Caenorhabditis elegans)
Secernentea W06B4.2 36 34 35
  • 43.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12788 34
Species where no ortholog for NAGK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAGK Gene

ENSEMBL:
Gene Tree for NAGK (if available)
TreeFam:
Gene Tree for NAGK (if available)

Paralogs for NAGK Gene

Pseudogenes.org Pseudogenes for NAGK Gene

genes like me logo Genes that share paralogs with NAGK: view

No data available for Paralogs for NAGK Gene

Variants for NAGK Gene

Sequence variations from dbSNP and Humsavar for NAGK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000022345 -- 71,069,491(+) TTTTC(A/T)CTTCT intron-variant
rs1000033671 -- 71,069,089(+) CAGGG(C/T)GGGGA intron-variant
rs1000087760 -- 71,075,483(+) GGAAG(A/G)CCAAC intron-variant
rs1000592129 -- 71,075,123(+) TTACA(A/G)TATGC intron-variant
rs1000696839 -- 71,077,008(+) AGCCA(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAGK Gene

Variant ID Type Subtype PubMed ID
esv32639 CNV gain 17666407
nsv1146915 OTHER inversion 26484159
nsv524446 CNV loss 19592680
nsv834256 CNV gain 17160897
nsv961790 CNV duplication 23825009

Variation tolerance for NAGK Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAGK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAGK Gene

Disorders for NAGK Gene

Relevant External Links for NAGK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAGK

No disorders were found for NAGK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAGK Gene

Publications for NAGK Gene

  1. Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. (PMID: 17010375) Weihofen W.A. … Hinderlich S. (J. Mol. Biol. 2006) 3 4 22 25 64
  2. Molecular cloning and characterization of murine and human N- acetylglucosamine kinase. (PMID: 10824116) Hinderlich S. … Reutter W. (Eur. J. Biochem. 2000) 2 3 4 22 64
  3. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N- glycolylneuraminic acid. (PMID: 22692205) Bergfeld A.K. … Varki A. (J. Biol. Chem. 2012) 3 4 64
  4. Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii. (PMID: 17229727) Nishimasu H. … Wakagi T. (J. Biol. Chem. 2007) 22 25 64
  5. Comparative proteomics of ovarian epithelial tumors. (PMID: 16674097) An H.J. … Cho N.H. (J. Proteome Res. 2006) 22 25 64

Products for NAGK Gene

  • Addgene plasmids for NAGK

Sources for NAGK Gene

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