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NAGK Gene

protein-coding   GIFtS: 63
GCID: GC02P071295

N-Acetylglucosamine Kinase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetylglucosamine Kinase1 2 3
GlcNAc Kinase2 3
EC 2.7.1.593 8
GNK2 5
HSA2429102
N-Acetyl-D-Glucosamine Kinase2

External Ids:    HGNC: 171741   Entrez Gene: 555772   Ensembl: ENSG000001243577   OMIM: 6068285   UniProtKB: Q9UJ703   

Export aliases for NAGK gene to outside databases

Previous GC identifers: GC02P071305 GC02P071506 GC02P071270 GC02P071207 GC02P071148 GC02P071031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAGK Gene:
This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion
of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers
amino sugars. (provided by RefSeq, Nov 2011)

GeneCards Summary for NAGK Gene:
NAGK (N-acetylglucosamine kinase) is a protein-coding gene. GO annotations related to this gene include N-acetylglucosamine kinase activity and N-acylmannosamine kinase activity.

UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from
lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid
(Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive
CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity

Gene Wiki entry for NAGK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAGK gene promoter:
         HOXA9   TBP   STAT1   Sp1   POU6F1 (c2)   GATA-1   Pax-3   Ik-2   FOXO4   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAGK promoter sequence
   Search Chromatin IP Primers for NAGK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p24.3-p24.1

NAGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAGK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P071295:  view genomic region     (about GC identifiers)

Start:
71,291,474 bp from pter      End:
71,306,935 bp from pter
Size:
15,462 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70 (See protein sequence)
Recommended Name: N-acetyl-D-glucosamine kinase  
Size: 344 amino acids; 37376 Da
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for NAGK:
2CH5 (3D)        2CH6 (3D)    
Secondary accessions: B4DLZ5 Q53HD5 Q6IA84 Q9BS29 Q9BVP0 Q9NV37
Alternative splicing: 2 isoforms:  Q9UJ70-1   Q9UJ70-2   

Explore the universe of human proteins at neXtProt for NAGK: NX_Q9UJ70

Explore proteomics data for NAGK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NAGK (Q9UJ70)
     KLRHSSALG  YGGVEGGGTRS  VAVLPEIDPVLFQG 


    See NAGK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060037.3  
    ENSEMBL proteins: 
     ENSP00000389087   ENSP00000436326   ENSP00000408550   ENSP00000396070   ENSP00000404531  
     ENSP00000411846   ENSP00000244204   ENSP00000400941   ENSP00000435207   ENSP00000435437  
     ENSP00000431204   ENSP00000437192  

    NAGK Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002731 ATPase_BadF

    Graphical View of Domain Structure for InterPro Entry Q9UJ70

    ProtoNet protein and cluster: Q9UJ70

    1 Blocks protein domain: IPB002731 ATPase

    UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
    Similarity: Belongs to the eukaryotic-type N-acetylglucosamine kinase family


    Find genes that share domains with NAGK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAGK_HUMAN, Q9UJ70
    Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from
    lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid
    (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive
    CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity
    Catalytic activity: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate

         Enzyme Number (IUBMB): EC 2.7.1.591 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0009384N-acylmannosamine kinase activity IEA--
    GO:0045127N-acetylglucosamine kinase activity IDA--
         
    Find genes that share ontologies with NAGK           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAGK:
     Decreased homologous recombina  Increased S DNA content, incre 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Nagk):
     normal 

    Find genes that share phenotypes with NAGK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAGK
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    miRNA
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    hsa-mir-17-5p (MIRT050916), hsa-mir-26b-5p (MIRT028866)

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    Selected qRT-PCR Assays for microRNAs that regulate NAGK (see all 9):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-3605-5p hsa-miR-93 hsa-miR-20b hsa-miR-17
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Addgene plasmids for NAGK 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    chloroplast1
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with NAGK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAGK About    
    See pathways by source

    SuperPathContained pathways About
    1Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism
    N-acetylglucosamine degradation II0.00


    Find genes that share SuperPaths with NAGK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NAGK
        N-acetylglucosamine degradation II



    1 Kegg Pathway  (Kegg details for NAGK):
        Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
    Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAGK
    Interactions:

        GeneGlobe Interaction Network for NAGK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAGK (Q9UJ701, 2, 3 ENSP000002442044) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB11, 2, 3, ENSP000002639254EBI-372578,EBI-739832 MINT-67311 I2D: score=5 STRING: ENSP00000263925
    DACH1Q9UI361, 3, ENSP000003527124EBI-372578,EBI-347111 I2D: score=4 STRING: ENSP00000352712
    FGFR1OPO956842, 3, ENSP000003558124MINT-8263467 I2D: score=2 STRING: ENSP00000355812
    PKMP146182, 3, ENSP000003201714MINT-8263489 I2D: score=2 STRING: ENSP00000320171
    SMAD2Q157962, 3, ENSP000002621604MINT-60929 I2D: score=2 STRING: ENSP00000262160
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006044N-acetylglucosamine metabolic process IEA--
    GO:0006051N-acetylmannosamine metabolic process TAS10824116
    GO:0019262N-acetylneuraminate catabolic process TAS--
    GO:0046835carbohydrate phosphorylation IDA--

    Find genes that share ontologies with NAGK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NAGK
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    Browse Tocris compounds for NAGK

    5 HMDB Compounds for NAGK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ChitinPoly 2-Acetamido-2-deoxy-D-glucose (see all 8)1398-61-4--
    N-Acetyl-D-Glucosamine 6-PhosphateN-Acetyl-D-Glucosamine 6-Phosphate (see all 7)102029-88-9--
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--

    1 DrugBank Compound for NAGK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Acetyl-D-glucosamine2-Acetamido-2-deoxy-D-glucose (see all 4)7512-17-6target--16674097 16857666 17229727 17010375 15489439

    9 Novoseek inferred chemical compound relationships for NAGK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglutamate 91.9 11 12875848 (2), 16122935 (1), 12351849 (1), 17425781 (1) (see all 7)
    n-acetylglucosamine 85.5 32 10824116 (6), 9468341 (4), 11308027 (3), 1312935 (2) (see all 14)
    carbamoyl phosphate 61.5 1 17425781 (1)
    sialic acid 54 1 1312935 (1)
    atp 42.9 8 12875848 (1), 17010375 (1), 10824116 (1), 19006331 (1) (see all 5)
    adp 41.9 3 17010375 (2), 19013524 (1)
    mannose 35.7 1 11298769 (1)
    arginine 32.8 8 16122935 (2), 19013524 (2), 16545809 (1), 17425781 (1)
    glucose 14.2 5 17010375 (2), 17229727 (1), 11298769 (1)



    Find genes that share compounds with NAGK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAGK gene: 
    NM_017567.4  

    Unigene Cluster for NAGK:

    N-acetylglucosamine kinase
    Hs.7036  [show with all ESTs]
    Unigene Representative Sequence: AK097223
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000531799 ENST00000497690 ENST00000455662 ENST00000531934 ENST00000455197
    ENST00000418807 ENST00000443872 ENST00000443938 ENST00000484984 ENST00000244204(uc002shp.4 uc002shq.4)
    ENST00000493102 ENST00000450272 ENST00000465105 ENST00000480411 ENST00000475709(uc002shr.3)
    ENST00000533981 ENST00000472519 ENST00000489309
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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-3605-5p hsa-miR-93 hsa-miR-20b hsa-miR-17
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      QuantiFast Probe-based Assays in human, mouse, rat NAGK

    Additional mRNA sequence: 

    AJ242910.1 AK001812.1 AK092876.1 AK097223.1 AK222645.1 AK297224.1 BC001029.2 BC005371.1 
    BC131781.1 CR457271.1 

    18 DOTS entries:

    DT.416482  DT.97809944  DT.99977142  DT.92436699  DT.305375  DT.100028615  DT.92436700  DT.92436698 
    DT.95300813  DT.120957174  DT.100641713  DT.120957173  DT.120957190  DT.92436696  DT.92436697  DT.95143517 
    DT.95294218  DT.97809003 

    Selected AceView cDNA sequences (see all 279):

    NM_017567 BF340680 AL832837 CD370002 CR591536 CR622455 CR609075 AA281320 
    CA392379 CR608802 BE856167 CR622456 AA054963 BQ641329 BQ436233 AI146728 
    BM691183 CA308248 BP338817 BE410198 BM716173 BQ430754 CA310493 BF446119 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAGK (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^
    SP1:                                            -     -     -                 -                       -                       -     -     -     -               
    SP2:                                                                          -                       -                       -     -     -     -               
    SP3:                                                                          -                       -                       -     -     -     -               
    SP4:                                            -     -     -                 -                       -                       -     -     -                     
    SP5:                                            -     -     -     -     -     -                       -                       -     -     -     -               

    ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:  -     -                       -     -                                       
    SP2:  -     -                       -     -                                       
    SP3:  -     -     -                 -     -                                       
    SP4:                                                                              
    SP5:  -     -                                                                     


    ECgene alternative splicing isoforms for NAGK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAGK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTATAGCG
    NAGK Expression
    About this image


    NAGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Lung (Respiratory System)
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    NAGK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAGK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7036

    UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NAGK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nagk1 , 5 N-acetylglucosamine kinase1, 5 87.27(n)1
    91.84(a)1
      6 (35.96 cM)5
    561741  NM_019542.21  NP_062415.11 
     837949825 
    lizard
    (Anolis carolinensis)
    Reptilia NAGK6
    N-acetylglucosamine kinase
    72(a)
    1 ↔ 1
    AAWZ02037460(2045-14966)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004859931 N-acetyl-D-glucosamine kinase-like 68.12(n)
    65.7(a)
      100485993  XM_002938397.2  XP_002938443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1716821 zgc:171682 63.21(n)
    63.21(a)
      100126013  NM_001105693.1  NP_001099163.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62181 , 3 CG62181 44(a)3
    51.86(n)1
    45.92(a)1
      88F13
    418631  NM_142191.11  NP_650448.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W06B4.21 , 3 W06B4.21 32(a)3
    43.72(n)1
    33.44(a)1
      II(4468165-4470943)3
    1737841  NM_062388.31  NP_494789.11 


    ENSEMBL Gene Tree for NAGK (if available)
    TreeFam Gene Tree for NAGK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAGK gene

    Find genes that share paralogs with NAGK           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NAGK
    PGOHUM00000258139


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAGK (see all 306)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835370391,2
    --71293536(+) TCCCAA/GGTAGC 1 -- us2k10--------
    rs1884601611,2
    --71293602(+) ACAGGG/TTCTCG 1 -- us2k10--------
    rs18333511,2
    C--71293610(-) caacaT/Gggcga 1 -- us2k15Minor allele frequency- G:0.11NA WA CSA 9
    rs742645911,2
    C--71293699(+) CCACCA/GCGCCC 1 -- us2k12Minor allele frequency- G:0.12CSA EA 121
    rs1391721031,2
    --71293752(+) TTCATA/TAATAG 1 -- us2k10--------
    rs3746504471,2
    C--71293792(+) CCAGA-/AGGAGAC 1 -- us2k10--------
    rs1495083881,2
    --71294019(+) ATTGAC/TGGGAC 1 -- us2k10--------
    rs1928186331,2
    --71294056(+) AAGTGC/TTCAGT 1 -- us2k10--------
    rs118902381,2
    C,F,H--71294128(+) TTAAGA/GTCTGT 1 -- us2k1 tfbs324Minor allele frequency- G:0.17NS EA NA WA 2904
    rs1158910651,2
    C,F--71294179(+) TCTTGC/TGTCAG 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for NAGK (71291474 - 71306935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NAGK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524446CNV Loss19592680
    nsv874253CNV Gain21882294
    esv32639CNV Gain17666407
    nsv834256CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NAGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606828    OMIM disorders: --


    Find genes that share disorders with NAGK           About GenesLikeMe


    Export disorders for NAGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAGK gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with NAGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. (PubMed id 17010375)1, 2, 7, 9 Weihofen W.A.... Hinderlich S. (J. Mol. Biol. 2006)
    2. Molecular cloning and characterization of murine and human N- acetylglucosamine kinase. (PubMed id 10824116)1, 2, 3, 9 Hinderlich S.... Reutter W. (Eur. J. Biochem. 2000)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Identification of the phosphotyrosine proteome from thrombin activated platelets. (PubMed id 12112843)1, 2 Maguire P.B....Fitzgerald D.J. (Proteomics 2002)
    8. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PubMed id 9468341)1, 9 Lowes W....Agius L. (Biochim. Biophys. Acta 1998)
    9. N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. (PubMed id 8982040)1, 9 Weidanz J.A....Vezza A.C. (Br. J. Haematol. 1996)
    10. Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii. (PubMed id 17229727)7, 9 Nishimasu H....Wakagi T. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55577 HGNC: 17174 AceView: NAGK Ensembl:ENSG00000124357 euGenes: HUgn55577
    ECgene: NAGK Kegg: 55577 H-InvDB: NAGK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAGK gene:
    Search GeneIP for patents involving NAGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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