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Aliases & Descriptions for NAGK
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.7.1.59 3 | | GNK 1, 2, 5 | | HSA242910 2 |
| | | Descriptions |
|---|
| GlcNAc kinase 3 | | N-acetylglucosamine kinase 2, 3 |
|
| | Search outside databases for aliases for NAGK genePrevious GC identifers: GC02P071305 GC02P071506 GC02P071270 |
Summaries for NAGK(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAGK: N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.[supplied by OMIM] UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Also has ManNAc kinase activity (By similarity)Gene Wiki entry for NAGK |
Genomic Location for NAGK
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAGK gene 
Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p24.3-p24.1NAGK Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P071207:
(about GC identifiers)
Start:
|
71,148,955 bp from pter |
End:
|
71,159,279 bp from pter |
Size:
|
10,325 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for NAGK
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70 (See
protein sequence)Recommended Name: N-acetyl-D-glucosamine kinase Size: 344 amino acids; 37376 Da
Subunit: Homodimer
PDB structure from and Proteopedia :2CH5 (3D)
 2CH6 (3D)
 
Secondary accessions: Q53HD5 Q6IA84 Q9BS29 Q9BVP0 Q9NV37Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060037.2
ENSEMBL proteins: ENSP00000244204
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005625 | soluble fraction |
IEA | -- | About this table
Antibodies for NAGK: Assays for NAGK: | Protein
Domains/ Families for NAGK(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UJ70
ProtoNet protein and cluster: Q9UJ70 1 Blocks protein family: IPB002731 ATPase
UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70Similarity: Belongs to the eukaryotic-type N-acetylglucosamine kinase family | Gene Function for NAGK
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017567
Applied Biosystems Silencer® siRNAs for NAGK
Sigma-Aldrich siRNA and siRNA Panels for NAGK  Sigma-Aldrich shRNA Panels and shRNA for NAGK  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017567                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017567                                  untagged cDNA clones in CMV expression vector (see all 3): AK092876 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017567
UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Also has ManNAc kinase activity (By similarity)Catalytic activity: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphateEnzyme Number (IUBMB): EC 2.7.1.59 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Nagk):
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for NAGK
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for NAGK (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for NAGK 
5/17 Interacting proteins for NAGK (ENSP000002442043 Q9UJ701, 2) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for NAGK(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAGK 8 Novoseek chemical compound relationships for NAGK gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| n-acetylglutamate |
90.75 |
10 |
12875848 (2), 16122935 (1), 12351849 (1), 16545809 (1) (see all 6) |
| n-acetylglucosamine |
85.76 |
32 |
10824116 (6), 9468341 (4), 11308027 (3), 1312935 (2) (see all 14) |
| carbamoyl phosphate |
61.99 |
1 |
17425781 (1) |
| sialic acid |
54.52 |
1 |
1312935 (1) |
| atp |
43.65 |
8 |
12875848 (1), 17010375 (1), 10824116 (1), 19006331 (1) (see all 5) |
| adp |
42.57 |
3 |
17010375 (2), 19013524 (1) |
| mannose |
36.64 |
1 |
11298769 (1) |
| glucose |
15.41 |
5 |
17010375 (2), 17229727 (1), 11298769 (1) |
About this table
|
Transcripts for NAGK(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017567
Sigma-Aldrich siRNA and siRNA Panels for NAGK  Sigma-Aldrich shRNA Panels and shRNA for NAGK  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_017567 REFSEQ mRNAs for NAGK gene: NM_017567.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017567               OriGene GFP tagged cDNA clone in CMV expression vector: NM_017567                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017567                                  untagged cDNA clones in CMV expression vector (see all 3): AK092876  Additional cDNA sequence: AJ242910.1 AK001812.1 AK092876.1 AK097223.1 AK222645.1 AK297224.1 BC001029.2 BC005371.1 BC131781.1 CR457271.1 CR591536.1 CR609075.1 CR615452.1 CR622455.1 CR622456.1 18 DOTS entries: DT.416482 DT.99977142 DT.97809944 DT.92436699 DT.100028615 DT.305375 DT.92436700 DT.92436698 DT.95300813 DT.120957174 DT.100641713 DT.120957173 DT.120957190 DT.92436696 DT.92436697 DT.95143517 DT.95294218 DT.97809003 24/279 AceView cDNA sequences (see all 279
):BP338817 BE856167 AW298245 CR622455 BM691183 AI146728 CR615452 F12441 BI918367 AL832837 CA308248 CR622456 BG575875 BM982771 AI694016 CR609075 NM_017567 BM716173 W16890 CD370002 AA369452 BE410198 BQ436233 BF725735
highest scoring ESTs for NAGK:AW026312 AA039704 AA053240 AA058760 AA281320 AA443840 AA446627 AA452800 AA452936 AA502611 Unigene Cluster for NAGK: N-acetylglucosamine kinase Hs.7036 [show with all ESTs]Unigene Representative Sequence: AK097223
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for NAGK (see all 18
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | · | 1i | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   |
| ExUns: | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | · | 8g | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | |
| SP1: | - |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | - |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAGK
1 Ensembl transcript including schematic representation: ENST00000244204
|
Expression for NAGK
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAGK expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAGK
1 / 2 / 3 4 probe-sets matching NAGK gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GACTATAGCG
SOURCE GeneReport for Unigene cluster: Hs.7036 UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70Tissue specificity: Ubiquitous |
Orthologs for NAGK
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAGK gene from 5/11 species (see all 11
)
About this table Species with no ortholog for NAGK
ENSEMBL Gene Tree for NAGK | Paralogs for NAGK(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for NAGK(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAGK (up to first 250kb)
|
Disorders & Mutations for NAGK
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606828
|
Medical News for NAGK(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAGK (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/36 PubMed articles for NAGK gene (see all 36
):- Molecular cloning and characterization of murine and human N- acetylglucosamine kinase. (PubMed id 10824116)1, 2, 3, 4 Hinderlich S.... Reutter W. (2000)
- Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. (PubMed id 17010375)1, 3, 4 Weihofen W.A.... Hinderlich S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)3, 4 Gevaert K.... Vandekerckhove J. (2003)
- Identification of the phosphotyrosine proteome from thrombin activated platelets. (PubMed id 12112843)3, 4 Maguire P.B....Fitzgerald D.J. (2002)
- Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PubMed id 9468341)1, 3 Lowes W....Agius L. (1998)
- N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. (PubMed id 8982040)1, 3 Weidanz J.A....Vezza A.C. (1996)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for NAGK
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAGK
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAGK
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAGK(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAGK(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAGK:

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