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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAGK Gene

protein-coding   GIFtS: 62
GCID: GC02P071295

N-Acetylglucosamine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Acetylglucosamine Kinase1 2 3
GlcNAc Kinase2 3
EC 2.7.1.593 8
GNK2 5
HSA2429102
N-Acetyl-D-Glucosamine Kinase2

External Ids:    HGNC: 171741   Entrez Gene: 555772   Ensembl: ENSG000001243577   OMIM: 6068285   UniProtKB: Q9UJ703   

Export aliases for NAGK gene to outside databases

Previous GC identifers: GC02P071305 GC02P071506 GC02P071270 GC02P071207 GC02P071148 GC02P071031


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAGK Gene:
This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion
of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers
amino sugars. (provided by RefSeq, Nov 2011)

GeneCards Summary for NAGK Gene: 
NAGK (N-acetylglucosamine kinase) is a protein-coding gene. Diseases associated with NAGK include myopathy, and neuroblastoma, and among its related super-pathways are N-acetylglucosamine degradation I. GO annotations related to this gene include N-acetylglucosamine kinase activity and ATP binding.

UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from
lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid
(Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive
CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity

Gene Wiki entry for NAGK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAGK gene promoter:
         HOXA9   TBP   STAT1   Sp1   POU6F1 (c2)   GATA-1   Pax-3   Ik-2   FOXO4   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAGK promoter sequence
   Search SABiosciences Chromatin IP Primers for NAGK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p24.3-p24.1

NAGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAGK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P071295:  view genomic region     (about GC identifiers)

Start:
71,291,474 bp from pter      End:
71,306,935 bp from pter
Size:
15,462 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70 (See protein sequence)
Recommended Name: N-acetyl-D-glucosamine kinase  
Size: 344 amino acids; 37376 Da
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for NAGK:
2CH5 (3D)        2CH6 (3D)    
Secondary accessions: B4DLZ5 Q53HD5 Q6IA84 Q9BS29 Q9BVP0 Q9NV37
Alternative splicing: 2 isoforms:  Q9UJ70-1   Q9UJ70-2   

Explore the universe of human proteins at neXtProt for NAGK: NX_Q9UJ70

Explore proteomics data for NAGK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJ70

  • 3 DME Specific Peptides for NAGK (Q9UJ70)
     KLRHSSALG  YGGVEGGGTRS  VAVLPEIDPVLFQG 

    NAGK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAGK Protein Expression
    REFSEQ proteins: NP_060037.3  
    ENSEMBL proteins: 
     ENSP00000389087   ENSP00000436326   ENSP00000408550   ENSP00000396070   ENSP00000404531  
     ENSP00000411846   ENSP00000400941   ENSP00000435207   ENSP00000435437   ENSP00000431204  
     ENSP00000437192   ENSP00000244204  

    Human Recombinant Protein Products for NAGK: 
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    Cloud-Clone Corp. ELISAs for NAGK 
    Cloud-Clone Corp. CLIAs for NAGK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002731 ATPase_BadF

    Graphical View of Domain Structure for InterPro Entry Q9UJ70

    ProtoNet protein and cluster: Q9UJ70

    1 Blocks protein domain: IPB002731 ATPase

    UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
    Similarity: Belongs to the eukaryotic-type N-acetylglucosamine kinase family


    NAGK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAGK_HUMAN, Q9UJ70
    Function: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from
    lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid
    (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive
    CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity
    Catalytic activity: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate

         Enzyme Number (IUBMB): EC 2.7.1.591 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0009384N-acylmannosamine kinase activity IEA--
    GO:0045127N-acetylglucosamine kinase activity IDA--
         
    NAGK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAGK:
     Decreased homologous recombina  Increased S DNA content, incre 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nagk):
     normal 

    NAGK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAGK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAGK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAGK 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAGK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NAGK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1N-acetylglucosamine degradation I
    N-acetylglucosamine degradation II0.75
    2Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NAGK
        N-acetylglucosamine degradation II


    1         Kegg Pathway  (Kegg details for NAGK):
        Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
    Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation


    NAGK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAGK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for NAGK (Q9UJ701, 2, 3 ENSP000002442044) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB11, 2, 3, ENSP000002639254EBI-372578,EBI-739832 MINT-67311 I2D: score=5 STRING: ENSP00000263925
    FGFR1OPO956842, 3, ENSP000003558124MINT-8263467 I2D: score=2 STRING: ENSP00000355812
    PKMP146182, 3, ENSP000003201714MINT-8263489 I2D: score=2 STRING: ENSP00000320171
    SMAD2Q157962, 3, ENSP000002621604MINT-60929 I2D: score=2 STRING: ENSP00000262160
    DYNC1I1O145762, 3MINT-8263456 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006044N-acetylglucosamine metabolic process IEA--
    GO:0006051N-acetylmannosamine metabolic process TAS10824116
    GO:0019262N-acetylneuraminate catabolic process TAS--

    NAGK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAGK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for NAGK

    Browse Tocris compounds for NAGK

    5 HMDB Compounds for NAGK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ChitinPoly 2-Acetamido-2-deoxy-D-glucose (see all 8)1398-61-4--
    N-Acetyl-D-Glucosamine 6-PhosphateN-Acetyl-D-Glucosamine 6-Phosphate (see all 7)102029-88-9--
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--

    1 DrugBank Compound for NAGK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Acetyl-D-glucosamine2-Acetamido-2-deoxy-D-glucose (see all 4)7512-17-6target--16674097 16857666 17229727 17010375 15489439

    9 Novoseek inferred chemical compound relationships for NAGK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglutamate 91.9 11 12875848 (2), 16122935 (1), 12351849 (1), 17425781 (1) (see all 7)
    n-acetylglucosamine 85.5 32 10824116 (6), 9468341 (4), 11308027 (3), 1312935 (2) (see all 14)
    carbamoyl phosphate 61.5 1 17425781 (1)
    sialic acid 54 1 1312935 (1)
    atp 42.9 8 12875848 (1), 17010375 (1), 10824116 (1), 19006331 (1) (see all 5)
    adp 41.9 3 17010375 (2), 19013524 (1)
    mannose 35.7 1 11298769 (1)
    arginine 32.8 8 16122935 (2), 19013524 (2), 16545809 (1), 17425781 (1)
    glucose 14.2 5 17010375 (2), 17229727 (1), 11298769 (1)

    Search CenterWatch for drugs/clinical trials and news about NAGK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAGK gene: 
    NM_017567.4  

    Unigene Cluster for NAGK:

    N-acetylglucosamine kinase
    Hs.7036  [show with all ESTs]
    Unigene Representative Sequence: AK097223
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000531799 ENST00000497690 ENST00000455662 ENST00000531934 ENST00000455197
    ENST00000418807 ENST00000443872 ENST00000443938 ENST00000484984 ENST00000493102
    ENST00000450272 ENST00000465105 ENST00000480411 ENST00000475709(uc002shr.3)
    ENST00000533981 ENST00000472519 ENST00000489309 ENST00000464638
    miRNA
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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-3605-5p hsa-miR-93 hsa-miR-20b hsa-miR-17
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    Additional mRNA sequence: 

    AJ242910.1 AK001812.1 AK092876.1 AK097223.1 AK222645.1 AK297224.1 BC001029.2 BC005371.1 
    BC131781.1 CR457271.1 

    18 DOTS entries:

    DT.416482  DT.97809944  DT.99977142  DT.92436699  DT.305375  DT.100028615  DT.92436700  DT.92436698 
    DT.95300813  DT.120957174  DT.100641713  DT.120957173  DT.120957190  DT.92436696  DT.92436697  DT.95143517 
    DT.95294218  DT.97809003 

    24/279 AceView cDNA sequences (see all 279):

    BV176700 BM691183 CR622455 AI694016 BF340680 CF128172 BF446119 CR608802 
    AA369452 AI658607 AL832837 BF869132 AW058671 AA281320 BE410198 BG575875 
    BE856167 BQ430754 BP338817 W16890 NM_017567 CA310493 AA947728 BF725735 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for NAGK (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^
    SP1:                                            -     -     -                 -                       -                       -     -     -     -               
    SP2:                                                                          -                       -                       -     -     -     -               
    SP3:                                                                          -                       -                       -     -     -     -               
    SP4:                                            -     -     -                 -                       -                       -     -     -                     
    SP5:                                            -     -     -     -     -     -                       -                       -     -     -     -               

    ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:  -     -                       -     -                                       
    SP2:  -     -                       -     -                                       
    SP3:  -     -     -                 -     -                                       
    SP4:                                                                              
    SP5:  -     -                                                                     


    ECgene alternative splicing isoforms for NAGK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAGK expression in normal human tissues (normalized intensities)      NAGK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTATAGCG
    NAGK Expression
    About this image


    NAGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Eye (Sensory Organs)
             Retina
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)
             skeleton/cranium   

    See NAGK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAGK

    SOURCE GeneReport for Unigene cluster: Hs.7036

    UniProtKB/Swiss-Prot: NAGK_HUMAN, Q9UJ70
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NAGK gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nagk1 , 5 N-acetylglucosamine kinase1, 5 87.27(n)1
    91.84(a)1
      6 (35.96 cM)5
    561741  NM_019542.21  NP_062415.11 
     837949825 
    lizard
    (Anolis carolinensis)
    Reptilia NAGK6
    Uncharacterized protein
    71(a)
    1 ↔ 1
    AAWZ02037460(2045-14966)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1716821 zgc:171682 63.21(n)
    63.21(a)
      100126013  NM_001105693.1  NP_001099163.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62181 , 3 CG62181 44(a)3
    51.86(n)1
    45.92(a)1
      88F13
    418631  NM_142191.11  NP_650448.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W06B4.21 , 3 Protein W06B4.21 32(a)3
    43.75(n)1
    33.55(a)1
      II(4468165-4470943)3
    1737841  NM_062388.21  NP_494789.11 


    ENSEMBL Gene Tree for NAGK (if available)
    TreeFam Gene Tree for NAGK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAGK gene

    NAGK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAGK
    PGOHUM00000258139


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/306 SNPs in NAGK are shown (see all 306)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835370391,2
    --71293536(+) TCCCAA/GGTAGC 1 -- us2k10--------
    rs1884601611,2
    --71293602(+) ACAGGG/TTCTCG 1 -- us2k10--------
    rs18333511,2
    C--71293610(-) caacaT/Gggcga 1 -- us2k15Minor allele frequency- G:0.11NA WA CSA 9
    rs742645911,2
    C--71293699(+) CCACCA/GCGCCC 1 -- us2k12Minor allele frequency- G:0.12CSA EA 121
    rs1391721031,2
    --71293752(+) TTCATA/TAATAG 1 -- us2k10--------
    rs3746504471,2
    C--71293792(+) CCAGA-/AGGAGAC 1 -- us2k10--------
    rs1495083881,2
    --71294019(+) ATTGAC/TGGGAC 1 -- us2k10--------
    rs1928186331,2
    --71294056(+) AAGTGC/TTCAGT 1 -- us2k10--------
    rs118902381,2
    C,F,H--71294128(+) TTAAGA/GTCTGT 1 -- us2k1 tfbs324Minor allele frequency- G:0.17NS EA NA WA 2904
    rs1158910651,2
    C,F--71294179(+) TCTTGC/TGTCAG 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for NAGK (71291474 - 71306935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NAGK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524446CNV Loss19592680
    nsv874253CNV Gain21882294
    esv32639CNV Gain17666407
    nsv834256CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606828    OMIM disorders: --

    2 diseases for NAGK:    About MalaCards
    myopathy    neuroblastoma


    NAGK for disorders           About GeneDecksing


    Export disorders for NAGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAGK gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with NAGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. (PubMed id 17010375)1, 2, 7, 9 Weihofen W.A.... Hinderlich S. (2006)
    2. Molecular cloning and characterization of murine and human N- acetylglucosamine kinase. (PubMed id 10824116)1, 2, 3, 9 Hinderlich S.... Reutter W. (2000)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Identification of the phosphotyrosine proteome from thrombin activated platelets. (PubMed id 12112843)1, 2 Maguire P.B....Fitzgerald D.J. (2002)
    8. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PubMed id 9468341)1, 9 Lowes W....Agius L. (1998)
    9. N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. (PubMed id 8982040)1, 9 Weidanz J.A....Vezza A.C. (1996)
    10. Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii. (PubMed id 17229727)7, 9 Nishimasu H....Wakagi T. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55577 HGNC: 17174 AceView: NAGK Ensembl:ENSG00000124357 euGenes: HUgn55577
    ECgene: NAGK Kegg: 55577 H-InvDB: NAGK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAGK gene:
    Search GeneIP for patents involving NAGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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