NAGA Gene
protein-coding GIFtS: 59
GCID: GC22M042428
|
|
N-acetylgalactosaminidase, alpha-
| |
Aliases
for NAGA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Acetylgalactosaminidase, Alpha-1 2 | | GALB2 | | D22S6741 2 | | Acetylgalactosaminidase, Alpha-N- (Alpha-Galactosidase B)2 | | Alpha-Galactosidase B2 3 | | Alpha-N-Acetylgalactosaminidase1 | | EC 3.2.1.493 8 | | EC 3.2.18 |
Export aliases for NAGA gene to outside databasesPrevious GC identifers: GC22M039068 GC22M040697 GC22M040778 GC22M040784 GC22M025420 |
Summaries
for NAGA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAGA:
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moietiesfrom glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type IIalso known as Kanzaki disease). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NAGAB_HUMAN, P17050Function: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for thebreakdown of glycolipids
Gene Wiki entry for NAGA
|
Genomic Views
for NAGA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAGA gene promoter:
GR Max1 AREB6 AML1a MyoD c-Myb GR-alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAGA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAGA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2NAGA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M042428: view genomic region
(about GC identifiers)
Start:
|
42,428,724 bp from pter |
End:
|
42,466,846 bp from pter |
Size:
|
38,123 bases |
Orientation:
|
minus strand |
|
Proteins
for NAGA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAGAB_HUMAN, P17050 (See
protein sequence)Recommended Name: Alpha-N-acetylgalactosaminidase precursor Size: 411 amino acids; 46565 Da
Subunit: Homodimer
Subcellular location: Lysosome
Miscellaneous: Alpha-galactosidase B was first found to be an isoenzyme of alpha-galactosidases, but apparently itdiffers from alpha-galactosidase A in substrate specificity and is alpha-N-acetylgalactosaminidase
Sequence caution: Sequence=AAA59902.1; Type=Frameshift; Positions=320;
6/7 PDB 3D structures from  and Proteopedia  for NAGA (see all 7):3H53 (3D)
3H54 (3D)
3H55 (3D)
3IGU (3D)
4DO4 (3D)
4DO5 (3D)
Explore the universe of human proteins at neXtProt for NAGA: NX_P17050
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17050
4/9 DME Specific Peptides for NAGA (P17050) (see all 9)
NAGA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000253.1
ENSEMBL proteins: ENSP00000419678 ENSP00000379680 ENSP00000385283 ENSP00000384603
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NAGA for ontologies About GeneDecksing
NAGA Antibody Products:
Assay Products for NAGA: |
Protein
Domains /
Families
for NAGA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAGA for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17050ProtoNet protein and cluster: P17050 1 Blocks protein family: IPB002241 Glycosyl hydrolase family 27 signature
UniProtKB/Swiss-Prot: NAGAB_HUMAN, P17050Similarity: Belongs to the glycosyl hydrolase 27 family |
Function
for NAGA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAGAB_HUMAN, P17050Function: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for thebreakdown of glycolipidsCatalytic activity: Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A andAB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids Genatlas biochemistry entry for NAGA:acetyl-galactosaminidase,alpha-N-,lyposomal,catalyzing the degradation of alpha-N-acetylgalactosaminyl-containingglycoconjugates
Enzyme Numbers (IUBMB): EC 3.2.1.491 2 EC 3.2.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAGA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAGA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NAGA (NM_000262) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAGA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAGA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAGA |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
NAGA for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Naga):
NAGA for phenotypes About GeneDecksing
|
Pathways & Interactions
for NAGA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lysosome | | | 2 | Glycosphingolipid biosynthesis - globo series | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for NAGA):
NAGA for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAGA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/15 Interacting proteins for NAGA (P170503 ENSP000003796804) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
NAGA for ontologies About GeneDecksing
|
Drugs & Compounds
for NAGA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NAGA for compounds About GeneDecksing
 Browse Tocris compounds for NAGA
2 HMDB Compounds for NAGA About this table
1 DrugBank Compound for NAGA About this table
9 Novoseek chemical compound relationships for NAGA gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| p-aminobenzoate |
65.5 |
1 |
2229011 (1) |
| gal(beta1-3)galnac |
61.3 |
1 |
9653936 (1) |
| glycolipid |
45.5 |
2 |
1418679 (1), 9741689 (1) |
| periodate |
37.1 |
1 |
9247192 (1) |
| n-acetylglucosamine |
32.9 |
1 |
17455791 (1) |
| atp |
0 |
1 |
1749310 (1) |
| glucose |
0 |
1 |
10456768 (1) |
| carbohydrates |
0 |
1 |
9808090 (1) |
| carbon |
0 |
1 |
17455791 (1) |
Search CenterWatch for drugs/clinical trials and news about NAGA / NAGAB
|
Transcripts
for NAGA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAGA gene: NM_000262.2 Unigene Cluster for NAGA: N-acetylgalactosaminidase, alpha- Hs.75372 [show with all ESTs]Unigene Representative Sequence: NM_0002624 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481068 ENST00000396398(uc003bbw.4) ENST00000403363 ENST00000402937
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAGA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAGA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAGA (NM_000262) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAGA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAGA |
Additional cDNA sequence: BC000095.2 CR456527.1 M29276.1 M38083.1 M62783.1 16 DOTS entries: DT.100823590 DT.455140 DT.100823595 DT.100823594 DT.95107270 DT.100698611 DT.95107235 DT.100823593 DT.100643645 DT.100696225 DT.100696639 DT.100712149 DT.100719562 DT.100823598 DT.95107273 DT.100777208 24/336 AceView cDNA sequences (see all 336): BM714986 CA748937 CR595848 CR621618 CR591632 BM714265 CR610763 BU584187 BQ645779 BX090389 CR618231 BX367373 BU170376 BX374419 CR599558 BI769830 BM676689 CR592922 BC000095 AL045023 CR595327 AA303896 AW296535 H44809
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NAGA About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NAGA
|
Expression
for NAGA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAGA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATTGGCTT
About this image
See NAGA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAGA
SOURCE GeneReport for Unigene cluster: Hs.75372
SABiosciences Custom PCR Arrays for NAGA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAGA
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAGA |
Orthologs
for NAGA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAGA gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NAGA1 |
N-acetylgalactosaminidase, alpha- |
73.96(n)
75.06(a) |
|
396547 NM_001167728.1 NP_001161200.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NAGA6-- |
-- |
70(a)55(a) |
1 ↔ 1possible ortholog |
5(27065125-27074871) GL343691.1(214999-226208) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.117182 |
Transcribed sequence with weak similarity to protein more |
75.61(n) |
|
57090518 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG57313
CG79971 |
alpha-N-acetylgalactosaminidase3
CG79971 |
52(a)
(best of 2)3
55.3(n)1
48.46(a)1 |
|
31B13
368291 NM_137275.31 NP_611119.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
R07B7.113 |
alpha-N-acetylgalactosaminidase |
45(a) |
|
V(12089834-12091423) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G563101 |
alpha-galactosidase |
50.1(n)
44.01(a) |
|
824798 NM_115489.5 NP_191190.2 |
rice
(Oryza sativa) |
Liliopsida |
Os07g06793001 |
hypothetical protein |
49.12(n)
44.12(a) |
|
4344290 NM_001067174.1 NP_001060639.1 |
ENSEMBL Gene Tree for NAGA (if available)
TreeFam Gene Tree for NAGA (if available) |
Paralogs
for NAGA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAGA gene
- GLA2
2 SIMAP similar genes for NAGA using alignment to 1 protein entry: NAGAB_HUMAN:GLA alpha-GalA
NAGA for paralogs About GeneDecksing
|
Genomic Variants
for NAGA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAGA (42428724 - 42466846 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAGA: --
Human Gene Mutation Database (HGMD): NAGA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAGA |
|
Disorders
/ Diseases
for NAGA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAGA for disorders About GeneDecksing
OMIM gene information: 104170
OMIM disorders: 609241 609242
UniProtKB/Swiss-Prot: NAGAB_HUMAN, P17050
Defects in NAGA are the cause of Schindler disease (SCHIND) [MIM:609241]. Schindler disease is a form of NAGAdeficiency characterized by early onset neuroaxonal dystrophy and neurological signs (convulsion during fever,epilepsy, psychomotor retardation and hypotonia). NAGA deficiency is typically classified in three main phenotypes:NAGA deficiency type I (Schindler disease or Schindler disease type I) with severe manifestations; NAGA deficiencytype II (Kanzazi disease or Schindler disease type II) which is mild; NAGA deficiency type III (Schindler disease typeIII) characterized by mild-to-moderate neurologic manifestations. NAGA deficiency results in the increased urinaryexcretion of glycopeptides and oligosaccharides containing alpha-N-acetylgalactosaminyl moieties. Inheritance isautosomal recessive Defects in NAGA are the cause of Kanzaki disease (KANZD) [MIM:609242]; also known as NAGA deficiency type IIor Schindler disease type II. Kanzaki disease is an autosomal recessive disorder characterized by late onset,angiokeratoma corporis diffusum and mild intellectual impairment
20/36  diseases for NAGA (see all 36): About MalaCardsschindler disease kanzaki disease schindler disease, type iii neuroaxonal dystrophy, infantile
neuroaxonal dystrophy beta-mannosidosis niemann-pick disease lysosomal storage disease
angiokeratoma blind loop syndrome sialidosis fucosidosis
mannosidosis type 1 diabetes mellitus fabry disease pick's disease
insulin resistance systemic lupus erythematosus lupus erythematosus diabetes mellitus
1 disease from the University of Copenhagen DISEASES database for NAGA:Fabry disease 10/16 Novoseek disease relationships for NAGA gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neuroaxonal dystrophies |
91.7 |
5 |
8466216 (1), 2122121 (1), 11313741 (1), 1907616 (1) (see all 5) |
| neuroaxonal dystrophy, infantile |
89.6 |
4 |
1907616 (2), 2122121 (1) |
| angiokeratoma |
83.6 |
3 |
7707696 (1), 1907616 (1) |
| fucosidosis |
81.7 |
4 |
10571005 (2), 2208741 (1), 2122119 (1) |
| fabry disease |
81.3 |
12 |
19853240 (3), 11251574 (2), 2208741 (2), 2160280 (1) (see all 6) |
| lysosomal storage diseases |
70.8 |
3 |
11251574 (1), 7707696 (1), 2208741 (1) |
| sialidosis |
66.1 |
2 |
2208741 (1), 2122119 (1) |
| enzyme deficiency |
57 |
1 |
8466216 (1) |
| deficiency diseases |
56.3 |
1 |
12005440 (1) |
| nephropathy iga |
49.3 |
1 |
18925530 (1) |
Genatlas disease: NAGA angiokeratoma corporis diffusum with glycopeptiduria,Schindler,Seitelberger disease,neuroaxonal dystrophy,infantileand adult types
Export disorders for NAGA gene to outside databases
|
Publications
for NAGA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAGA gene, integrated from 9 sources (see all 122):
(articles sorted by number of sources associating them with NAGA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of two species of cDNAs for human alpha-N- acetylgalactosaminidase and expression in mammalian cells. (PubMed id 2372288)1, 2, 9 Yamauchi T.... Tsuji S. (1990)
- The 1.9 A structure of human alpha-N-acetylgalactosaminidase: the molecular basis of Schindler and Kanzaki diseases. (PubMed id 19683538)1, 2, 9 Clark N.E. and Garman S.C. (2009)
- A new case of alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum, with Meniere's syndrome and without mental retardation. (PubMed id 11251574)1, 2, 9 Kodama K.... Kanzaki T. (2001)
- Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts. (PubMed id 9741689)1, 2, 9 Asfaw B....Conzelmann E. (1998)
- Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and phenotype. (PubMed id 8782044)1, 2, 9 Keulemans J.L.M.... van Diggelen O.P. (1996)
- The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria. (PubMed id 8040340)1, 2, 9 Wang A.M.... Desnick R.J. (1994)
- Structural organization and complete sequence of the human alpha-N- acetylgalactosaminidase gene: homology with the alpha-galactosidase A gene provides evidence for evolution from a common ancestral gene. (PubMed id 1646157)1, 2, 9 Wang A.M. and Desnick R.J. (1991)
- Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene. (PubMed id 2174888)1, 2, 9 Wang A.M.... Desnick R.J. (1990)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for NAGA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NAGA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NAGA gene
(According to HUGE)
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Specialized Databases showing NAGA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for NAGA | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NAGA |
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| Patent Information for NAGA gene:
Search GeneIP for patents involving NAGA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NAGA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NAGA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAGA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAGA | | | OriGene Protein Over-expression Lysate for NAGA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAGA | | OriGene 3'-UTR Clone for NAGA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAGA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAGA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NAGA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAGA | | OriGene Custom Protein Services for NAGA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAGA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAGA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAGA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAGA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAGA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAGA |
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| | | | Search Tocris compounds for NAGA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAGA |
|  |  |  | | | | Search ThermoFisher Antibodies for NAGA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAGA |
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