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Aliases for NAF1 Gene

Aliases for NAF1 Gene

  • Nuclear Assembly Factor 1 Ribonucleoprotein 2 3
  • Nuclear Assembly Factor 1 Homolog (S. Cerevisiae) 2
  • KIAA0113 6
  • TNIP1 6
  • HNAF1 4

External Ids for NAF1 Gene

Previous GeneCards Identifiers for NAF1 Gene

  • GC04M164270
  • GC04M164047
  • GC04M159801

Summaries for NAF1 Gene

GeneCards Summary for NAF1 Gene

NAF1 (Nuclear Assembly Factor 1 Ribonucleoprotein) is a Protein Coding gene. Among its related pathways are Immune response IL-23 signaling pathway and EGFR1 Signaling Pathway. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for NAF1 Gene

  • RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAF1 Gene

Genomics for NAF1 Gene

Regulatory Elements for NAF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAF1 Gene

Start:
163,084,037 bp from pter
End:
163,166,921 bp from pter
Size:
82,885 bases
Orientation:
Minus strand

Genomic View for NAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAF1 Gene

Proteins for NAF1 Gene

  • Protein details for NAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HR8-NAF1_HUMAN
    Recommended name:
    H/ACA ribonucleoprotein complex non-core subunit NAF1
    Protein Accession:
    Q96HR8
    Secondary Accessions:
    • D3DP28
    • E9PAZ2

    Protein attributes for NAF1 Gene

    Size:
    494 amino acids
    Molecular mass:
    53717 Da
    Quaternary structure:
    • During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4.

    Three dimensional structures from OCA and Proteopedia for NAF1 Gene

    Alternative splice isoforms for NAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAF1 Gene

Proteomics data for NAF1 Gene at MOPED

Post-translational modifications for NAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAF1 Gene

Antibody Products

No data available for DME Specific Peptides for NAF1 Gene

Domains for NAF1 Gene

Protein Domains for NAF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HR8

UniProtKB/Swiss-Prot:

NAF1_HUMAN :
  • Q96HR8
Family:
  • Belongs to the NAF1 family.
genes like me logo Genes that share domains with NAF1: view

No data available for Gene Families for NAF1 Gene

Function for NAF1 Gene

Molecular function for NAF1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.

Gene Ontology (GO) - Molecular Function for NAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 16618814
GO:0005515 protein binding IPI 16601202
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NAF1: view

Animal Model Products

miRNA for NAF1 Gene

miRTarBase miRNAs that target NAF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAF1 Gene

Localization for NAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAF1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAF1 Gene COMPARTMENTS Subcellular localization image for NAF1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005732 small nucleolar ribonucleoprotein complex IDA 16601202
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NAF1: view

Pathways for NAF1 Gene

genes like me logo Genes that share pathways with NAF1: view

Pathways by source for NAF1 Gene

2 Qiagen pathways for NAF1 Gene
1 Cell Signaling Technology pathway for NAF1 Gene
2 BioSystems pathways for NAF1 Gene

Gene Ontology (GO) - Biological Process for NAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0006364 rRNA processing IEA --
GO:0042254 ribosome biogenesis IDA 16618814
genes like me logo Genes that share ontologies with NAF1: view

Transcripts for NAF1 Gene

Unigene Clusters for NAF1 Gene

Nuclear assembly factor 1 ribonucleoprotein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for NAF1 Gene

GeneLoc Exon Structure for
NAF1
ECgene alternative splicing isoforms for
NAF1

Expression for NAF1 Gene

mRNA expression in normal human tissues for NAF1 Gene

Protein differential expression in normal tissues for NAF1 Gene

This gene is overexpressed in Lung (26.1), CD4 Tcells (11.6), Testis (8.6), and Fetal ovary (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAF1 Gene

SOURCE GeneReport for Unigene cluster for NAF1 Gene Hs.129095

genes like me logo Genes that share expressions with NAF1: view

Expression partners for NAF1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAF1 Gene

Orthologs for NAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAF1 35
NAF1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAF1 35
  • 89.05 (n)
  • 85.88 (a)
NAF1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naf1 35
  • 84.1 (n)
  • 82.18 (a)
Naf1 16
Naf1 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAF1 35
  • 99.26 (n)
  • 98.99 (a)
NAF1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naf1 35
  • 78.26 (n)
  • 78.34 (a)
oppossum
(Monodelphis domestica)
Mammalia NAF1 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAF1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAF1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAF1 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25832 35
zebrafish
(Danio rerio)
Actinopterygii naf1 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10341 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAF1 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for NAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAF1 Gene

ENSEMBL:
Gene Tree for NAF1 (if available)
TreeFam:
Gene Tree for NAF1 (if available)

Paralogs for NAF1 Gene

genes like me logo Genes that share paralogs with NAF1: view

No data available for Paralogs for NAF1 Gene

Variants for NAF1 Gene

Sequence variations from dbSNP and Humsavar for NAF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4017 -- 163,142,947(+) GATTC(C/T)GGAAC intron-variant
rs4023 -- 163,143,038(+) TAGCA(C/T)CTGAG intron-variant
rs767651 -- 163,121,878(-) AAACA(A/C)TTCTT intron-variant
rs936562 -- 163,166,802(-) GTTTT(A/T)CTATT utr-variant-5-prime
rs936564 -- 163,098,611(-) TCCTC(C/T)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAF1 Gene

Variant ID Type Subtype PubMed ID
nsv4585 CNV Loss 18451855
esv2469391 CNV Deletion 19546169
esv2664805 CNV Deletion 23128226
esv2728663 CNV Deletion 23290073
nsv289298 CNV Loss 16902084
esv271797 CNV Insertion 20981092
nsv822811 CNV Gain 20364138

Relevant External Links for NAF1 Gene

HapMap Linkage Disequilibrium report
NAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAF1 Gene

Disorders for NAF1 Gene

Relevant External Links for NAF1

Genetic Association Database (GAD)
NAF1
Human Genome Epidemiology (HuGE) Navigator
NAF1

No disorders were found for NAF1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NAF1 Gene

Publications for NAF1 Gene

  1. hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase. (PMID: 16601202) Hoareau-Aveilla C. … Henry Y. (RNA 2006) 2 3 4
  2. Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells. (PMID: 16618814) Darzacq X. … Meier U.T. (J. Cell Biol. 2006) 2 3 4
  3. Dynamic association and localization of human H/ACA RNP proteins. (PMID: 17135485) Kittur N. … Meier U.T. (RNA 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Common variants in the trichohyalin gene are associated with straight hair in Europeans. (PMID: 19896111) Medland S.E. … Martin N.G. (Am. J. Hum. Genet. 2009) 3 48

Products for NAF1 Gene

Sources for NAF1 Gene

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