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NAF1 Gene

protein-coding   GIFtS: 49
GCID: GC04M164047

Nuclear Assembly Factor 1 Ribonucleoprotein

(Previous name: nuclear assembly factor 1 homolog (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Assembly Factor 1 Ribonucleoprotein1 2     hNAF13
Nuclear Assembly Factor 1 Homolog (S. Cerevisiae)1     KIAA01135
H/ACA Ribonucleoprotein Complex Non-Core Subunit NAF12     TNIP15
Nuclear Assembly Factor 1 Homolog2     

External Ids:    HGNC: 251261   Entrez Gene: 923452   Ensembl: ENSG000001454147   OMIM: 6077145   UniProtKB: Q96HR83   

Export aliases for NAF1 gene to outside databases

Previous GC identifers: GC04M164270 GC04M159801


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NAF1 Gene:
NAF1 (nuclear assembly factor 1 ribonucleoprotein) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: NAF1_HUMAN, Q96HR8
Function: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis.
During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of
the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with
NOLA1/GAR1 for binding with DKC1/NOLA4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAF1 gene promoter:
         STAT1   p300   STAT1beta   HSF1 (long)   STAT1alpha   MEF-2A   AREB6   HFH-1   HSF1short   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAF1 promoter sequence
   Search Chromatin IP Primers for NAF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.2   Ensembl cytogenetic band:  4q32.2   HGNC cytogenetic band: 4q32.2

NAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAF1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M164047:  view genomic region     (about GC identifiers)

Start:
164,031,225 bp from pter      End:
164,088,073 bp from pter
Size:
56,849 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NAF1_HUMAN, Q96HR8 (See protein sequence)
Recommended Name: H/ACA ribonucleoprotein complex non-core subunit NAF1  
Size: 494 amino acids; 53717 Da
Subunit: During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing
H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts
directly with DKC1/NOLA4
1 PDB 3D structure from and Proteopedia for NAF1:
2EQN (3D)    
Secondary accessions: D3DP28 E9PAZ2
Alternative splicing: 2 isoforms:  Q96HR8-1   Q96HR8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NAF1: NX_Q96HR8

Explore proteomics data for NAF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NAF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122403.1  NP_612395.2  

    ENSEMBL proteins: 
     ENSP00000427518   ENSP00000408963   ENSP00000274054  

    NAF1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NAF1

     
    Search eBioscience for Proteins for NAF1 

     
    antibodies-online proteins for NAF1 (5 products) 

     
    Search antibodies-online for peptides for NAF1

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    antibodies-online antibodies for NAF1 (4 products) 

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    antibodies-online kits for NAF1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007504 H/ACA_rnp_Gar1/Naf1
     IPR009000 Transl_B-barrel

    Graphical View of Domain Structure for InterPro Entry Q96HR8

    ProtoNet protein and cluster: Q96HR8

    UniProtKB/Swiss-Prot: NAF1_HUMAN, Q96HR8
    Similarity: Belongs to the NAF1 family


    Find genes that share domains with NAF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAF1_HUMAN, Q96HR8
    Function: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis.
    During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of
    the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with
    NOLA1/GAR1 for binding with DKC1/NOLA4

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA16618814
    GO:0005515protein binding IPI16601202
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NAF1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NAF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAF1:
    hsa-let-7b-5p (MIRT032447), hsa-mir-615-3p (MIRT040431)

    Block miRNA regulation of human, mouse, rat NAF1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NAF1:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAF1 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAF1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAF1_HUMAN, Q96HR8: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the
    nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005732small nucleolar ribonucleoprotein complex IDA16601202
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome ----
    GO:0030054cell junction ----

    Find genes that share ontologies with NAF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NAF1
        14-3-3 Induced Apoptosis
    Angiopoietin-TIE2 Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAF1
    Interactions:

        GeneGlobe Interaction Network for NAF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAF1 (Q96HR81, 2, 3 ENSP000002740544) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BADQ929342, 3, ENSP000003091034MINT-7717137 I2D: score=1 STRING: ENSP00000309103
    CANXP278242, 3, ENSP000002474614MINT-7712875 I2D: score=1 STRING: ENSP00000247461
    CYCSP999992, 3, ENSP000003077864MINT-7712884 I2D: score=1 STRING: ENSP00000307786
    BCL2P104151, 2, 3, ENSP000003296234EBI-2515597,EBI-77694 MINT-7712862 MINT-7717145 I2D: score=1 STRING: ENSP00000329623
    DKC1O608321, ENSP000003585634EBI-2515597,EBI-713091 STRING: ENSP00000358563
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis IEA--
    GO:0006364rRNA processing IEA--
    GO:0042254ribosome biogenesis IDA16618814

    Find genes that share ontologies with NAF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAF1 gene (2 alternative transcripts): 
    NM_001128931.1  NM_138386.2  

    Unigene Cluster for NAF1:

    Nuclear assembly factor 1 ribonucleoprotein
    Hs.129095  [show with all ESTs]
    Unigene Representative Sequence: AK097352
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509434 ENST00000422287(uc010iqw.1) ENST00000274054(uc003iqj.3)
    ENST00000509884 ENST00000509232 ENST00000502973
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate NAF1:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAF1
    Predesigned siRNA for gene silencing in human, mouse, rat NAF1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): NAF1 (NM_001128931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAF1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NAF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAF1
      QuantiTect SYBR Green Assays in human, mouse, rat NAF1
      QuantiFast Probe-based Assays in human, mouse, rat NAF1

    Additional mRNA sequence: 

    AK097352.1 AK308601.1 BC008207.1 

    4 DOTS entries:

    DT.406805  DT.100020829  DT.101961616  DT.99974448 

    Selected AceView cDNA sequences (see all 49):

    CR622366 AK126037 AI923378 CR611986 BX103045 BX096010 CF128149 AA321245 
    AK097352 AI886391 AI652820 BX641702 BX107765 CD385920 AI452422 BF110552 
    BX508033 BX383358 BI869579 BM463276 NM_138386 BX330880 CA446497 AL559696 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NAF1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                -     -                             -               
    SP2:                                -     -                                             
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for NAF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NAF1 Expression
    About this image

    NAF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129095
        Custom PCR Arrays for NAF1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naf11 , 5 nuclear assembly factor 1 homolog (S. cerevisiae)1, 5 84.1(n)1
    82.18(a)1
      8 (33.18 cM)5
    2343441  NM_001163564.11  NP_001157036.11 
     668602175 
    chicken
    (Gallus gallus)
    Aves NAF16
    nuclear assembly factor 1 ribonucleoprotein
    47(a)
    1 ↔ 1
    4(22769795-22787997)
    lizard
    (Anolis carolinensis)
    Reptilia NAF16
    nuclear assembly factor 1 ribonucleoprotein
    68(a)
    1 ↔ 1
    5(126231086-126237336)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.258322 Xenopus laevis transcribed sequence with weak similarity more 75.69(n)    BG413749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AI657832.12   -- 73.28(n)    AI657832.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103416
    --
    22(a)
    1 ↔ 1
    2L(18698719-18700645)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAF16
    RNA-binding protein required for the assembly of b...
    21(a)
    1 ↔ 1
    XIV(392892-394370) YNL124W


    ENSEMBL Gene Tree for NAF1 (if available)
    TreeFam Gene Tree for NAF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAF1 gene
    2 SIMAP similar genes for NAF1 using alignment to 13 protein entries:     NAF1_HUMAN (see all proteins):
    TNIP1    TNIP3

    Find genes that share paralogs with NAF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAF1 (see all 737)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419942931,2
    --164047367(+) GCAAGA/GCTATA 1 -- ds50010--------
    rs1389372651,2
    C--164047534(+) CCTCA-/TTAATA 1 -- ds50010--------
    rs1463266481,2
    --164047548(+) TTGAGG/TTGTTT 1 -- ds50010--------
    rs1485431081,2
    --164047563(+) CTTCAC/TTGGAG 1 -- ds50010--------
    rs1919679161,2
    --164047632(+) AAGATA/GTGACT 1 -- ds50010--------
    rs785295091,2
    --164047740(+) GAAGAC/TGCTAT 1 -- ds50010--------
    rs755656151,2
    F--164047763(+) AATGAT/CAACAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs762375731,2
    C,F--164047821(+) TGAGAG/CGACTT 1 -- ds50011Minor allele frequency- C:0.07EA 120
    rs607356071,2
    C,F--164047844(+) CAAAGT/GTTTAC 1 -- ds50013Minor allele frequency- G:0.29WA NA 240
    rs1832569501,2
    --164047881(+) TCACAG/TGCTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NAF1 (164031225 - 164088073 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NAF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728663CNV Deletion23290073
    esv2664805CNV Deletion23128226
    esv2469391CNV Deletion19546169
    esv271797CNV Insertion20981092
    nsv4585CNV Loss18451855
    nsv289298CNV Loss16902084
    nsv822811CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAF1
    DNA2.0 Custom Variant and Variant Library Synthesis for NAF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607714    OMIM disorders: --


    Find genes that share disorders with NAF1           About GenesLikeMe

    Genetic Association Database (GAD): NAF1
    Human Genome Epidemiology (HuGE) Navigator: NAF1 (15 documents)

    Export disorders for NAF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAF1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NAF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase. (PubMed id 16601202)1, 2, 3 Hoareau-Aveilla C.... Henry Y. (RNA 2006)
    2. Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells. (PubMed id 16618814)1, 2, 3 Darzacq X.... Meier U.T. (J. Cell Biol. 2006)
    3. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)1, 4 Kim H.Y....Kim H. (BMB Rep 2010)
    4. Common variants in the trichohyalin gene are associated with straight hair in Europeans. (PubMed id 19896111)1, 4 Medland S.E....Martin N.G. (Am. J. Hum. Genet. 2009)
    5. Dynamic association and localization of human H/ACA RNP proteins. (PubMed id 17135485)1, 2 Kittur N.... Meier U.T. (RNA 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. A bead-based approach for large-scale identification of in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (Proteomics 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92345 HGNC: 25126 AceView: LOC92345 Ensembl:ENSG00000145414 euGenes: HUgn92345
    ECgene: NAF1 H-InvDB: NAF1

    (According to HUGE)
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    HUGE: KIAA0113

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAF1 gene:
    Search GeneIP for patents involving NAF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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