Aliases for NAE1 Gene
- NEDD8 Activating Enzyme E1 Subunit 1 2 3
- APPBP1 3 4 6
- Amyloid Beta Precursor Protein-Binding Protein 1, 59 KDa 3 4
- Amyloid Beta Precursor Protein Binding Protein 1, 59kDa 2 3
- Amyloid Protein-Binding Protein 1 3 4
- Proto-Oncogene Protein 1 3 4
- APP-BP1 3 4
- Amyloid Beta Precursor Protein-Binding Protein 1, 59kD 3
External Ids for NAE1 Gene
Previous Symbols for NAE1 Gene
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAE1 Gene
NAE1 (NEDD8 Activating Enzyme E1 Subunit 1) is a Protein Coding gene. Among its related pathways are Alzheimers disease and Alzheimers disease. GO annotations related to this gene include protein heterodimerization activity and NEDD8 activating enzyme activity.
UniProtKB/Swiss-Prot for NAE1 Gene
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.