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NAE1 Gene

protein-coding GIFtS: 57

GC16M065395

NEDD8 activating enzyme E1 subunit 1
(Previous names: amyloid beta precursor protein-binding protein 1, 59kD, amyloid beta precursor protein binding protein 1, 59kDa, amyloid beta precursor protein binding protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: APPBP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A-116A10.1 ^²
APP-BP1 ^³
APPBP1 ^², ³, ⁵
HPP1 ^²
ula-1 ^¹, ²

Descriptions
Amyloid beta precursor protein-binding protein 1, 59 kDa ^³
Amyloid protein-binding protein 1 ^², ³
NEDD8 activating enzyme E1 subunit 1 ^²
NEDD8-activating enzyme E1 subunit ^²
Proto-oncogene protein 1 ^³
amyloid beta precursor protein binding protein 1 ^¹
amyloid beta precursor protein binding protein 1, 59kDa ^¹, ²
amyloid beta precursor protein-binding protein 1, 59kD ^¹, ²
protooncogene protein 1 ^²

External Ids
HGNC: 621¹
Entrez Gene: 8883²
UniProtKB: Q13564³
Ensembl: ENSG00000159593⁷

Search outside databases for aliases for NAE1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAE1:

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid

precursor protein is a cell surface protein with signal-transducing properties, and it is thought

to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein

can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This

protein is required for cell cycle progression through the S/M checkpoint. Three transcript

variants encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ULA1_HUMAN, Q13564

Function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first

adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side

chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally

transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through

the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8

conjugation

Gene Wiki entry for NAE1 (APPBP1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22

NAE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M065395: (about GC identifiers)

Start:	65,394,279 bp from pter
End:	65,422,380 bp from pter
Size:	28,102 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ULA1_HUMAN, Q13564 (See protein sequence)

Recommended Name: NEDD8-activating enzyme E1 regulatory subunit

Size: 534 amino acids; 60246 Da

Subunit: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2

Subcellular location: Cell membrane. Note=Colocalizes with APP in lipid rafts

Miscellaneous: NAE1 and UBA3 correspond to the N-terminal and the C-terminal part of yeast UBA3. In

yeast the two subunits form a single polypeptide chain

PDB structures from and Proteopedia :

1R4M (3D)

1R4N (3D)

1TT5 (3D)

1YOV (3D)

2NVU (3D)

3DBH (3D)

3DBL (3D)

3DBR (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001018169.1 NP_001018170.1 NP_003896.1

ENSEMBL proteins:

ENSP00000290810 ENSP00000377637 ENSP00000368776 ENSP00000351990

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (APPBP1)
	Human Recombinant Proteins from Abnova (NAE1)

OriGene Purified Recombinant Human Protein: NAE1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005626	insoluble fraction	IDA	14557245
GO:0005737	cytoplasm	TAS	8626687
GO:0005886	plasma membrane	IEA	--

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Antibodies for NAE1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NAE1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (APPBP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NAE1)
	Novus Biologicals Antibodies for NAE1

Assays for NAE1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13564

ProtoNet protein and cluster: Q13564

1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold

UniProtKB/Swiss-Prot: ULA1_HUMAN, Q13564

Similarity: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAE1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAE1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003905

Applied Biosystems Silencer® siRNAs for NAE1

Sigma-Aldrich siRNA and siRNA Panels for NAE1

Sigma-Aldrich shRNA Panels and shRNA for NAE1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAE1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001018159
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001018159
untagged cDNA clones in CMV expression vector (see all 3): NM_001018159

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003905

UniProtKB/Swiss-Prot: ULA1_HUMAN, Q13564

Function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first

adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side

chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally

transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through

the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8

conjugation

Enzyme regulation: Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	IEA	--
GO:0005515	protein binding	IPI	8626687 10722740 12694406 14557245 15361859
GO:0019781	contributes to NEDD8 activating enzyme activity	IPI	12740388
GO:0046982	protein heterodimerization activity	IPI	12740388

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ULA1_HUMAN, Q13564

Pathway: Protein modification; protein neddylation

Gene Network Central^TM Interacting Genes and Proteins Network for NAE1

5/182 Interacting proteins for NAE1 (ENSP00000290810³ Q13564^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 182 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2MP1	P61081¹^,²	EBI-718631, EBI-1041660 MINT-6542674
NEDD8	Q15843²	STRING (score=.999) MINT-6542674
UBC	P62988²	STRING (score=.871) MINT-6542674
UBE2M	P61081¹^,²	STRING (score=.998) EBI-718631, EBI-1041660 MINT-6542674 EBI-718631, EBI-1041660 MINT-6542674
UBE2M	P61081¹^,²	STRING (score=.998) EBI-718631, EBI-1041660 MINT-6542674 EBI-718631, EBI-1041660 MINT-6542674

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IDA	14557245
GO:0007049	cell cycle	IEA	--
GO:0007165	signal transduction	TAS	8626687
GO:0008152	metabolic process	IEA	--
GO:0019941	modification-dependent protein catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAE1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAE1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAE1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003905

Sigma-Aldrich siRNA and siRNA Panels for NAE1

Sigma-Aldrich shRNA Panels and shRNA for NAE1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018159 NM_001018160 NM_003905

REFSEQ mRNAs for NAE1 gene (3 alternative transcripts):

NM_001018159.1 NM_001018160.1 NM_003905.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018159 NM_001018160 NM_003905

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001018159
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001018159
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001018159

Additional cDNA sequence:

AK097680.1 AK298159.1 AK307677.1 AK312784.1 AL136798.1 AY197612.1 BC000480.2 BC013301.2

BC041323.2 CR597312.1 CR611333.1 CR614006.1 U50939.1

22 DOTS entries:

DT.86847561 DT.97802551 DT.92448264 DT.417295 DT.101982931 DT.95177720 DT.100796436 DT.40132947

DT.92448266 DT.100712589 DT.100796442 DT.92017156 DT.95177762 DT.100646036 DT.100703919 DT.100865362

DT.120675278 DT.91977513 DT.95177712 DT.120675252 DT.40132949 DT.91698729

24/301 AceView cDNA sequences (see all 301 ):

BM788716 BQ716155 BM785899 BQ935849 NM_003905 AL136798 CA429735 BM827917

BP371260 AW328271 BM788741 AU142742 CR597312 CR611333 BE788060 BM978806

AU137597 AA353343 BQ430637 BU625325 AW328270 H91836 CA775105 BU752325

Unigene Cluster for NAE1:

NEDD8 activating enzyme E1 subunit 1

Hs.460978 [show with all ESTs]

Unigene Representative Sequence: NM_001018159

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NAE1

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:											-				-														-								-
SP2:							-				-				-														-								-
SP3:							-				-
SP4:
SP5:							-

About this scheme

ECgene alternative splicing isoforms for NAE1

4 Ensembl transcripts including schematic representations:

ENST00000290810 ENST00000394074 ENST00000379463 ENST00000359087

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAE1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAE1

¹ / ²

3 probe-sets matching NAE1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35364_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
202268_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
202268_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCACAAACTT

SOURCE GeneReport for Unigene cluster: Hs.460978
UniProtKB/Swiss-Prot: ULA1_HUMAN, Q13564
Tissue specificity: Ubiquitous in fetal tissues. Expressed throughout the adult brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAE1 gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAE1¹	--	NEDD8 activating enzyme E1 subunit 1	95.76(n) 97.75(a)	610026 XM_846910.1 XP_852003.1
chimpanzee (Pan troglodytes)	NAE1¹	--	NEDD8 activating enzyme E1 subunit 1	99.69(n) 99.44(a)	467995 XM_001159481.1 XP_001159481.1
cow (Bos taurus)	NAE1¹	--	NEDD8 activating enzyme E1 subunit 1	94.94(n) 97.75(a)	614491 XM_866024.2 XP_871117.2
rat (Rattus norvegicus)	Nae1¹	--	NEDD8 activating enzyme E1 subunit 1	92.38(n) 96.82(a)	84019 NM_032072.2 NP_114461.1
mouse (Mus musculus)	Nae1^{1, 5}	8⁵	NEDD8 activating enzyme E1 subunit 1^{1, 5}	92.51(n)¹ 97(a)¹	234664¹ NM_144931.2¹ NP_659180.1¹ AI846393⁵ AK038756⁵ (see all 16)

About this table Species with no ortholog for NAE1

ENSEMBL Gene Tree for NAE1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NAE1 gene

SAE1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/145 NCBI SNPs in NAE1 are shown (see all 145 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs422945^1,2	A,C,F,H,O	65424134(+)	`TGGACG/TTCATG`	3	--	ng3¹		13	MN EU EA WA NA	1230
	rs461943^1,2	C,F,H	65423778(+)	`GTGAAC/AATGAA`	3	--	ng3¹		5	EU EA WA	1878
	rs152164^1,2	C,F,H	65419467(+)	`CAAATA/GTATGG`	3	--	int¹ ut5¹		13	EA NA EU WA	2468
	rs363212^1,2	C,F,H	65414952(+)	`TTCCAG/AAGACA`	3	F/S	mis¹ ese³		12	EU EA WA	1252
	rs467117^1,2	C,F	65422909(-)	`TGAGAC/GTAAAC`	3	--	ng3¹		6	EA MN NA	762
--	rs11556607^1,2	H	65418144(-)	`CTGCTC/TATGTT`	3	H/Y	mis¹ int¹ ese³		4	EU EA WA	404
	rs363219^1,2	F	65422449(+)	`GCACGC/GGTCGC`	3	--	ng3¹		1	MN	184
	rs3026091^1,2	H	65422711(+)	`TTTGAC/ACTTAA`	3	--	ng3¹		3	EA WA	246
	rs363169^1,2	A,C,F,H,O	65400295(+)	`TCTTTT/AATATC`	3	--	int¹		12	NS NA EU EA WA	660
	rs363172^1,2	A,C,F,H,O	65402525(+)	`CCAAGG/AAAAGT`	3	--	int¹		7	EU EA WA NA	550

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HapMap Linkage Disequilibrium images for NAE1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603385

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/23 PubMed articles for NAE1 gene (see all 23 ):

Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. (PubMed id 12740388)^{2, 3, 4} Bohnsack R.N. and Haas A.L. (2003)
APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. (PubMed id 8626687)^{2, 3, 4} Chow N.... Neve R.L. (1996)
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. (PubMed id 14557245)^{1, 3, 4} Chen Y.... Neve R.L. (2003)
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PubMed id 15361859)^{3, 4} Huang D.T.... Schulman B.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. (PubMed id 12646924)^{3, 4} Walden H.... Schulman B.A. (2003)
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PubMed id 14690597)^{3, 4} Walden H.... Schulman B.A. (2003)
ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. (PubMed id 12694406)^{3, 4} Chen Y.... Neve R.L. (2003)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. (PubMed id 10722740)^{3, 4} Chen Y.... Neve R.L. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8883	HGNC: 621	AceView: APPBP1	Ensembl:ENSG00000159593	euGenes: HUgn8883
ECgene: NAE1	H-InvDB: NAE1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for NAE1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAE1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAE1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAE1		Antibodies for NAE1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAE1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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NAE1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for NAE1

Summaries
for NAE1

Genomic Location
for NAE1

Proteins
for NAE1

Protein Domains/
Families
for NAE1

Gene Function
for NAE1

Pathways & Interactions
for NAE1

Drugs & Compounds
for NAE1

Transcripts
for NAE1

Expression
for NAE1

Orthologs
for NAE1

Paralogs
for NAE1

SNPs/Variants
for NAE1

Disorders & Mutations
for NAE1

Medical News
for NAE1

Publications
for NAE1

Search for NAE1

Genome Databases showing NAE1

Other Databases showing NAE1

Specialized Databases showing NAE1

Licensable Technologies
for NAE1

Services
for NAE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAE1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor NAE1

Summariesfor NAE1

Genomic Locationfor NAE1

Proteinsfor NAE1

Protein Domains/Familiesfor NAE1

Gene Functionfor NAE1

Pathways & Interactionsfor NAE1

Drugs & Compoundsfor NAE1

Transcriptsfor NAE1

Expression for NAE1

Orthologsfor NAE1

Paralogsfor NAE1

SNPs/Variantsfor NAE1

Disorders & Mutationsfor NAE1

Medical Newsfor NAE1

Publicationsfor NAE1

Search for NAE1

Genome Databases showing NAE1

Other Databases showing NAE1

Specialized Databases showing NAE1

Licensable Technologiesfor NAE1

Servicesfor NAE1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAE1

Summaries
for NAE1

Genomic Location
for NAE1

Proteins
for NAE1

Protein Domains/
Families
for NAE1

Gene Function
for NAE1

Pathways & Interactions
for NAE1

Drugs & Compounds
for NAE1

Transcripts
for NAE1

Expression
for NAE1

Orthologs
for NAE1

Paralogs
for NAE1

SNPs/Variants
for NAE1

Disorders & Mutations
for NAE1

Medical News
for NAE1

Publications
for NAE1

Licensable Technologies
for NAE1

Services
for NAE1