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Aliases for NADSYN1 Gene

Aliases for NADSYN1 Gene

  • NAD Synthetase 1 2 3 5
  • NAD(+) Synthase [Glutamine-Hydrolyzing] 4
  • NAD(+) Synthetase 4
  • EC 6.3.5.1 4

External Ids for NADSYN1 Gene

Previous GeneCards Identifiers for NADSYN1 Gene

  • GC11P070890
  • GC11P070841
  • GC11P071164
  • GC11P067459

Summaries for NADSYN1 Gene

Entrez Gene Summary for NADSYN1 Gene

  • Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]

GeneCards Summary for NADSYN1 Gene

NADSYN1 (NAD Synthetase 1) is a Protein Coding gene. Among its related pathways are Tryptophan metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and NAD+ synthase (glutamine-hydrolyzing) activity.

Gene Wiki entry for NADSYN1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NADSYN1 Gene

Genomics for NADSYN1 Gene

Regulatory Elements for NADSYN1 Gene

Enhancers for NADSYN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NADSYN1 on UCSC Golden Path with GeneCards custom track

Promoters for NADSYN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NADSYN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NADSYN1 Gene

Chromosome:
11
Start:
71,453,109 bp from pter
End:
71,524,107 bp from pter
Size:
70,999 bases
Orientation:
Plus strand

Genomic View for NADSYN1 Gene

Genes around NADSYN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NADSYN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NADSYN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADSYN1 Gene

Proteins for NADSYN1 Gene

  • Protein details for NADSYN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IA69-NADE_HUMAN
    Recommended name:
    Glutamine-dependent NAD(+) synthetase
    Protein Accession:
    Q6IA69
    Secondary Accessions:
    • B3KUU4
    • Q86SN2
    • Q9HA25
    • Q9NVM8

    Protein attributes for NADSYN1 Gene

    Size:
    706 amino acids
    Molecular mass:
    79285 Da
    Quaternary structure:
    • Homohexamer.

    Alternative splice isoforms for NADSYN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NADSYN1 Gene

Proteomics data for NADSYN1 Gene at MOPED

Post-translational modifications for NADSYN1 Gene

  • Ubiquitination at Lys 421, Lys 642, and Lys 649
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NADSYN1 Gene

Domains & Families for NADSYN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IA69

UniProtKB/Swiss-Prot:

NADE_HUMAN :
  • Contains 1 CN hydrolase domain.
  • In the C-terminal section; belongs to the NAD synthetase family.
Domain:
  • Contains 1 CN hydrolase domain.
Family:
  • In the C-terminal section; belongs to the NAD synthetase family.
genes like me logo Genes that share domains with NADSYN1: view

No data available for Gene Families for NADSYN1 Gene

Function for NADSYN1 Gene

Molecular function for NADSYN1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.49 mM for deamido-NAD(+) {ECO:0000269 PubMed:12547821}; KM=0.089 mM for ATP {ECO:0000269 PubMed:12547821}; KM=1.44 mM for glutamine {ECO:0000269 PubMed:12547821}; KM=13.1 mM for ammonium {ECO:0000269 PubMed:12547821}; Vmax=0.99 nmol/min/ug enzyme deamido-NAD(+) {ECO:0000269 PubMed:12547821}; Vmax=0.61 nmol/min/ug enzyme ATP {ECO:0000269 PubMed:12547821}; Vmax=0.70 nmol/min/ug enzyme glutamine {ECO:0000269 PubMed:12547821}; Vmax=1.04 nmol/min/ug enzyme ammonium {ECO:0000269 PubMed:12547821};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate.

Enzyme Numbers (IUBMB) for NADSYN1 Gene

Gene Ontology (GO) - Molecular Function for NADSYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity TAS --
genes like me logo Genes that share ontologies with NADSYN1: view
genes like me logo Genes that share phenotypes with NADSYN1: view

Animal Models for NADSYN1 Gene

MGI Knock Outs for NADSYN1:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NADSYN1 Gene

Localization for NADSYN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NADSYN1 Gene COMPARTMENTS Subcellular localization image for NADSYN1 gene
Compartment Confidence
cytosol 5
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NADSYN1 Gene

Pathways & Interactions for NADSYN1 Gene

genes like me logo Genes that share pathways with NADSYN1: view

Pathways by source for NADSYN1 Gene

UniProtKB/Swiss-Prot Q6IA69-NADE_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.

Gene Ontology (GO) - Biological Process for NADSYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NADSYN1: view

No data available for SIGNOR curated interactions for NADSYN1 Gene

Drugs & Compounds for NADSYN1 Gene

(9) Drugs for NADSYN1 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Streptozocin Approved Pharma Antibiotic and antitumor agent 9
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for NADSYN1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Nicotinic acid adenine dinucleotide
  • Deamido-NAD+
  • Deamidonicotinamide adenine dinucleoetide
  • Deamino-nad+
  • NAAD
  • NaADN
6450-77-7
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(1) ApexBio Compounds for NADSYN1 Gene

Compound Action Cas Number
Streptozocin Antibiotic and antitumor agent 18883-66-4
genes like me logo Genes that share compounds with NADSYN1: view

Transcripts for NADSYN1 Gene

Unigene Clusters for NADSYN1 Gene

NAD synthetase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NADSYN1 Gene

No ASD Table

Relevant External Links for NADSYN1 Gene

GeneLoc Exon Structure for
NADSYN1
ECgene alternative splicing isoforms for
NADSYN1

Expression for NADSYN1 Gene

mRNA expression in normal human tissues for NADSYN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NADSYN1 Gene

This gene is overexpressed in Lymph node (15.4) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NADSYN1 Gene



SOURCE GeneReport for Unigene cluster for NADSYN1 Gene Hs.556986

genes like me logo Genes that share expression patterns with NADSYN1: view

Protein tissue co-expression partners for NADSYN1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NADSYN1 Gene

Orthologs for NADSYN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NADSYN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NADSYN1 35
  • 86.87 (n)
  • 90.37 (a)
NADSYN1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NADSYN1 35
  • 86.69 (n)
  • 88.67 (a)
NADSYN1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nadsyn1 35
  • 83.5 (n)
  • 86.02 (a)
Nadsyn1 16
Nadsyn1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NADSYN1 35
  • 99.15 (n)
  • 99.29 (a)
NADSYN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nadsyn1 35
  • 82.84 (n)
  • 85.49 (a)
oppossum
(Monodelphis domestica)
Mammalia NADSYN1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves NADSYN1 35
  • 71.7 (n)
  • 77.64 (a)
NADSYN1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NADSYN1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nadsyn1 35
  • 70.88 (n)
  • 76.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32794 35
zebrafish
(Danio rerio)
Actinopterygii nadsyn1 35
  • 66.81 (n)
  • 71.9 (a)
CABZ01069576.1 36
  • 69 (a)
OneToMany
nadsyn1 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000112 35
  • 61.21 (n)
  • 57.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9940 35
  • 59.47 (n)
  • 60 (a)
CG9940 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea qns-1 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR358W 35
  • 56.92 (n)
  • 58.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13024g 35
  • 55.78 (n)
  • 59.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes QNS1 35
  • 55.75 (n)
  • 59.26 (a)
QNS1 36
  • 57 (a)
OneToOne
QNS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G55090 35
  • 52.87 (n)
  • 52.68 (a)
rice
(Oryza sativa)
Liliopsida Os.27399 35
Os07g0167100 35
  • 54.6 (n)
  • 53.9 (a)
corn
(Zea mays)
Liliopsida Zm.7969 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.836 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04648 35
  • 58.9 (n)
  • 57.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC553.02 35
  • 55.06 (n)
  • 57.55 (a)
Species with no ortholog for NADSYN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NADSYN1 Gene

ENSEMBL:
Gene Tree for NADSYN1 (if available)
TreeFam:
Gene Tree for NADSYN1 (if available)

Paralogs for NADSYN1 Gene

No data available for Paralogs for NADSYN1 Gene

Variants for NADSYN1 Gene

Sequence variations from dbSNP and Humsavar for NADSYN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2276360 - 71,458,501(+) CCCTT(A/C/G)TGGAG reference, missense
rs7121106 - 71,480,771(+) GAGCC(C/T)CTACC reference, missense
rs35007971 - 71,497,491(+) GATAT(A/G)GGGAT reference, missense
rs12282060 - 71,501,341(+) TGGAC(A/G)GCGTG reference, missense
VAR_058703 -

Structural Variations from Database of Genomic Variants (DGV) for NADSYN1 Gene

Variant ID Type Subtype PubMed ID
nsv897896 CNV Gain 21882294
nsv897897 CNV Loss 21882294
dgv74n21 CNV Loss 19592680
nsv897898 CNV Loss 21882294

Variation tolerance for NADSYN1 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.92; 79.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NADSYN1 Gene

Disorders for NADSYN1 Gene

Relevant External Links for NADSYN1

Genetic Association Database (GAD)
NADSYN1
Human Genome Epidemiology (HuGE) Navigator
NADSYN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NADSYN1

No disorders were found for NADSYN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NADSYN1 Gene

Publications for NADSYN1 Gene

  1. Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. (PMID: 12547821) Hara N. … Tsuchiya M. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Glutamine-dependent NAD+ synthetase. How a two-domain, three-substrate enzyme avoids waste. (PMID: 16954203) Wojcik M. … Brenner C. (J. Biol. Chem. 2006) 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes. (PMID: 26149120) Xu X. … Gao M. (Med. Sci. Monit. 2015) 3

Products for NADSYN1 Gene

Sources for NADSYN1 Gene

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