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Aliases for NADSYN1 Gene

Aliases for NADSYN1 Gene

  • NAD Synthetase 1 2 3
  • NAD(+) Synthase [Glutamine-Hydrolyzing] 4
  • NAD(+) Synthetase 4
  • EC 4

External Ids for NADSYN1 Gene

Previous GeneCards Identifiers for NADSYN1 Gene

  • GC11P070890
  • GC11P070841
  • GC11P071164
  • GC11P067459

Summaries for NADSYN1 Gene

Entrez Gene Summary for NADSYN1 Gene

  • Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]

GeneCards Summary for NADSYN1 Gene

NADSYN1 (NAD Synthetase 1) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and NAD+ synthase (glutamine-hydrolyzing) activity.

Gene Wiki entry for NADSYN1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NADSYN1 Gene

Genomics for NADSYN1 Gene

Regulatory Elements for NADSYN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NADSYN1 Gene

71,453,109 bp from pter
71,524,107 bp from pter
70,999 bases
Plus strand

Genomic View for NADSYN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NADSYN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADSYN1 Gene

Proteins for NADSYN1 Gene

  • Protein details for NADSYN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamine-dependent NAD(+) synthetase
    Protein Accession:
    Secondary Accessions:
    • B3KUU4
    • Q86SN2
    • Q9HA25
    • Q9NVM8

    Protein attributes for NADSYN1 Gene

    706 amino acids
    Molecular mass:
    79285 Da
    Quaternary structure:
    • Homohexamer.

    Alternative splice isoforms for NADSYN1 Gene


neXtProt entry for NADSYN1 Gene

Proteomics data for NADSYN1 Gene at MOPED

Post-translational modifications for NADSYN1 Gene

  • Ubiquitination at Lys421, Lys642, and Lys649
  • Modification sites at PhosphoSitePlus

Other Protein References for NADSYN1 Gene

Antibody Products

No data available for DME Specific Peptides for NADSYN1 Gene

Domains for NADSYN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6IA69
  • Contains 1 CN hydrolase domain.
  • In the C-terminal section; belongs to the NAD synthetase family.
genes like me logo Genes that share domains with NADSYN1: view

No data available for Gene Families for NADSYN1 Gene

Function for NADSYN1 Gene

Molecular function for NADSYN1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.49 mM for deamido-NAD(+) {ECO:0000269 PubMed:12547821}; KM=0.089 mM for ATP {ECO:0000269 PubMed:12547821}; KM=1.44 mM for glutamine {ECO:0000269 PubMed:12547821}; KM=13.1 mM for ammonium {ECO:0000269 PubMed:12547821}; Vmax=0.99 nmol/min/ug enzyme deamido-NAD(+) {ECO:0000269 PubMed:12547821}; Vmax=0.61 nmol/min/ug enzyme ATP {ECO:0000269 PubMed:12547821}; Vmax=0.70 nmol/min/ug enzyme glutamine {ECO:0000269 PubMed:12547821}; Vmax=1.04 nmol/min/ug enzyme ammonium {ECO:0000269 PubMed:12547821};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate

Enzyme Numbers (IUBMB) for NADSYN1 Gene

Gene Ontology (GO) - Molecular Function for NADSYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with NADSYN1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NADSYN1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NADSYN1 Gene

Localization for NADSYN1 Gene

Subcellular locations from

Jensen Localization Image for NADSYN1 Gene COMPARTMENTS Subcellular localization image for NADSYN1 gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NADSYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NADSYN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NADSYN1 Gene

Pathways for NADSYN1 Gene

SuperPathways for NADSYN1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Nicotinate and nicotinamide metabolism
3 tryptophan utilization II
4 Metabolism
5 Disease
genes like me logo Genes that share pathways with NADSYN1: view

UniProtKB/Swiss-Prot Q6IA69-NADE_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1

Gene Ontology (GO) - Biological Process for NADSYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006807 nitrogen compound metabolic process --
GO:0009435 NAD biosynthetic process IEA --
GO:0019674 NAD metabolic process TAS --
genes like me logo Genes that share ontologies with NADSYN1: view

Compounds for NADSYN1 Gene

(1) ApexBio Compounds for NADSYN1 Gene

Compound Action Cas Number
Streptozocin Antibiotic and antitumor agent [18883-66-4]

(11) HMDB Compounds for NADSYN1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • Amfamox
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
  • (2S)-2,5-diamino-5-oxopentanoic acid

(2) Drugbank Compounds for NADSYN1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 enzyme substrate
genes like me logo Genes that share compounds with NADSYN1: view

Transcripts for NADSYN1 Gene

Unigene Clusters for NADSYN1 Gene

NAD synthetase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NADSYN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NADSYN1 Gene

No ASD Table

Relevant External Links for NADSYN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NADSYN1 Gene

mRNA expression in normal human tissues for NADSYN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NADSYN1 Gene

This gene is overexpressed in Lymph node (15.4) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NADSYN1 Gene

SOURCE GeneReport for Unigene cluster for NADSYN1 Gene Hs.556986

genes like me logo Genes that share expressions with NADSYN1: view

Expression partners for NADSYN1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NADSYN1 Gene

Orthologs for NADSYN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NADSYN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NADSYN1 35
  • 86.87 (n)
  • 90.37 (a)
  • 90 (a)
(Canis familiaris)
Mammalia NADSYN1 35
  • 86.69 (n)
  • 88.67 (a)
  • 83 (a)
(Mus musculus)
Mammalia Nadsyn1 35
  • 83.5 (n)
  • 86.02 (a)
Nadsyn1 16
Nadsyn1 36
  • 83 (a)
(Pan troglodytes)
Mammalia NADSYN1 35
  • 99.15 (n)
  • 99.29 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Nadsyn1 35
  • 82.84 (n)
  • 85.49 (a)
(Monodelphis domestica)
Mammalia NADSYN1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 74 (a)
(Gallus gallus)
Aves NADSYN1 35
  • 71.7 (n)
  • 77.64 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia NADSYN1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nadsyn1 35
  • 70.88 (n)
  • 76.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32794 35
(Danio rerio)
Actinopterygii nadsyn1 35
  • 66.81 (n)
  • 71.9 (a)
CABZ01069576.1 36
  • 69 (a)
nadsyn1 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000112 35
  • 61.21 (n)
  • 57.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9940 35
  • 59.47 (n)
  • 60 (a)
CG9940 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea qns-1 36
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR358W 35
  • 56.92 (n)
  • 58.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13024g 35
  • 55.78 (n)
  • 59.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes QNS1 35
  • 55.75 (n)
  • 59.26 (a)
QNS1 36
  • 57 (a)
QNS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G55090 35
  • 52.87 (n)
  • 52.68 (a)
(Oryza sativa)
Liliopsida Os.27399 35
Os07g0167100 35
  • 54.6 (n)
  • 53.9 (a)
(Zea mays)
Liliopsida Zm.7969 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.836 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04648 35
  • 58.9 (n)
  • 57.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC553.02 35
  • 55.06 (n)
  • 57.55 (a)
Species with no ortholog for NADSYN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NADSYN1 Gene

Gene Tree for NADSYN1 (if available)
Gene Tree for NADSYN1 (if available)

Paralogs for NADSYN1 Gene

No data available for Paralogs for NADSYN1 Gene

Variants for NADSYN1 Gene

Sequence variations from dbSNP and Humsavar for NADSYN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs732934 -- 71,475,430(+) TGTGG(A/G)TGCTC intron-variant
rs732935 -- 71,475,587(+) GCGGC(C/T)AAAGA intron-variant
rs751389 -- 71,501,961(-) ATAAA(C/G)AGACA downstream-variant-500B
rs753352 -- 71,490,152(-) GGAAA(A/T)GGCGG intron-variant
rs949178 -- 71,489,274(-) CAACA(A/G)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NADSYN1 Gene

Variant ID Type Subtype PubMed ID
nsv897896 CNV Gain 21882294
nsv897897 CNV Loss 21882294
dgv74n21 CNV Loss 19592680
nsv897898 CNV Loss 21882294

Relevant External Links for NADSYN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NADSYN1 Gene

Disorders for NADSYN1 Gene

Relevant External Links for NADSYN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NADSYN1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NADSYN1 Gene

Publications for NADSYN1 Gene

  1. Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. (PMID: 12547821) Hara N. … Tsuchiya M. (J. Biol. Chem. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 48
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48

Products for NADSYN1 Gene

Sources for NADSYN1 Gene

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