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Aliases & Descriptions for NADSYN1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.3.5.1 3 | | FLJ10631 1, 2 | | FLJ36703 2 | | FLJ40627 2 |
| | | Descriptions |
|---|
| NAD synthetase 1 2 | | NAD(+) synthase [glutamine-hydrolyzing] 3 | | NAD(+) synthetase 1 3 | | glutamine-dependent NAD synthetase 2 |
|
| | Search outside databases for aliases for NADSYN1 genePrevious GC identifers: GC11P071386 GC11P070890 |
Summaries for NADSYN1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NADSYN1: Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM] Gene Wiki entry for NADSYN1 |
Genomic Location for NADSYN1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NADSYN1 gene 
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4NADSYN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P070841:
(about GC identifiers)
Start:
|
70,841,865 bp from pter |
End:
|
70,890,232 bp from pter |
Size:
|
48,368 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033927.7
| Proteins for NADSYN1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NADE1_HUMAN, Q6IA69 (See
protein sequence)Recommended Name: Glutamine-dependent NAD(+) synthetase Size: 706 amino acids; 79294 Da
Subunit: Homohexamer
Secondary accessions: Q86SN2 Q9HA25 Q9NVM8REFSEQ proteins: NP_060631.2
ENSEMBL proteins: ENSP00000326424
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NADSYN1 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for NADSYN1: Assays for NADSYN1: | Protein
Domains/ Families for NADSYN1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6IA69
ProtoNet protein and cluster: Q6IA69 2 Blocks protein families: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase IPB003694 NAD+ synthase
UniProtKB/Swiss-Prot: NADE1_HUMAN, Q6IA69Similarity: In the C-terminal section; belongs to the NAD synthetase familySimilarity: Contains 1 CN hydrolase domain | Gene Function for NADSYN1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018161
Applied Biosystems Silencer® siRNAs for NADSYN1
Sigma-Aldrich siRNA for NADSYN1  Sigma-Aldrich shRNA for NADSYN1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018161                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018161                                  untagged cDNA clone in CMV expression vector: NM_018161 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018161
UniProtKB/Swiss-Prot: NADE1_HUMAN, Q6IA69Catalytic activity: ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamateEnzyme Number (IUBMB): EC 6.3.5.1 5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003952 | NAD+ synthase (glutamine-hydrolyzing) activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 15231747 | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
IEA | -- | About this table | Pathways & Interactions for NADSYN1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for NADSYN1 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: NADE1_HUMAN, Q6IA69Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (glutamine route): step 1/1 5/20 Interacting proteins for NADSYN1 (ENSP000003264243 Q6IA691) via UniProtKB, MINT, and/or STRING (see all 20
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006807 | nitrogen compound metabolic process |
IEA | -- | | GO:0009435 | NAD biosynthetic process |
IEA | -- | About this table
|
Drugs & Compounds for NADSYN1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NADSYN1
|
Transcripts for NADSYN1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018161
Sigma-Aldrich siRNA for NADSYN1  Sigma-Aldrich shRNA for NADSYN1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018161 REFSEQ mRNAs for NADSYN1 gene: NM_018161.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018161               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018161                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018161                                  untagged cDNA clone in CMV expression vector: NM_018161  Additional cDNA sequence: AB091316.1 AK001493.1 AK022436.1 AK055452.1 AK094022.1 AK097940.1 AK097946.1 AK225700.1 AL512694.1 BC003638.2 BC003666.2 BC020977.1 CR457286.1 22 DOTS entries: DT.413773 DT.100787908 DT.100036310 DT.95307509 DT.86844688 DT.91741720 DT.95107745 DT.100787916 DT.99930233 DT.120683340 DT.413775 DT.97802378 DT.97856969 DT.99982468 DT.100787914 DT.120683339 DT.92012346 DT.92034641 DT.97822559 DT.99964869 DT.87011015 DT.95107741 24/263 AceView cDNA sequences (see all 263
):CD370172 AW263058 AA465522 AI927502 AA857884 BE158957 BU684632 BQ719229 AI669045 AK097946 BC015237 AL530760 BX283748 BF514939 AI658748 CA487729 BM728592 BG272124 AI744722 AI186846 AI921634 AU122486 BG289242 BF591019
highest scoring ESTs for NADSYN1:AA178924 AA417583 AA417691 AA432078 AA446879 AA447224 AA480502 AA514351 AA551669 AA573433 Unigene Cluster for NADSYN1: NAD synthetase 1 Hs.556986 [show with all ESTs]Unigene Representative Sequence: BC020977
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000319023
|
Expression for NADSYN1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NADSYN1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NADSYN1
1 / 2 / 3 8 probe-sets matching NADSYN1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACAGACACA
SOURCE GeneReport for Unigene cluster: Hs.556986
|
Orthologs for NADSYN1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NADSYN1 gene from 5/20 species (see all 20
)
About this table Species with no ortholog for NADSYN1
ENSEMBL Gene Tree for NADSYN1 | Paralogs for NADSYN1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for NADSYN1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NADSYN1 (up to first 250kb)
|
Disorders & Mutations for NADSYN1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608285
|
Medical News for NADSYN1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NADSYN1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for NADSYN1 gene: |
Search for NADSYN1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NADSYN1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NADSYN1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NADSYN1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NADSYN1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NADSYN1:

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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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