Aliases for NADK2 Gene
External Ids for NADK2 Gene
Previous HGNC Symbols for NADK2 Gene
This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
GeneCards Summary for NADK2 Gene
NADK2 (NAD Kinase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with NADK2 include progressive encephalopathy with leukodystrophy due to decr deficiency and 2,4-dienoyl-coa reductase deficiency. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include protein homodimerization activity and NAD+ kinase activity.
UniProtKB/Swiss-Prot for NADK2 Gene
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.