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Aliases for NADK2 Gene

Aliases for NADK2 Gene

  • NAD Kinase 2, Mitochondrial 2 3
  • NAD Kinase Domain-Containing Protein 1, Mitochondrial 3 4
  • Mitochondrial NAD Kinase 2 4
  • C5orf33 3 4
  • NADKD1 3 4
  • MNADK 3 4
  • Chromosome 5 Open Reading Frame 33 2
  • NAD Kinase Domain Containing 1 2
  • EC 2.7.1.23 4
  • DECRD 3

External Ids for NADK2 Gene

Previous Symbols for NADK2 Gene

  • C5orf33
  • NADKD1

Summaries for NADK2 Gene

Entrez Gene Summary for NADK2 Gene

  • This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for NADK2 Gene

NADK2 (NAD Kinase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with NADK2 include 2,4-dienoyl-coa reductase deficiency. GO annotations related to this gene include protein homodimerization activity and NAD+ kinase activity.

UniProtKB/Swiss-Prot for NADK2 Gene

  • Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NADK2 Gene

Genomics for NADK2 Gene

Genomic Location for NADK2 Gene

Start:
36,192,589 bp from pter
End:
36,242,279 bp from pter
Size:
49,691 bases
Orientation:
Minus strand

Genomic View for NADK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NADK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADK2 Gene

No data available for Regulatory Elements for NADK2 Gene

Proteins for NADK2 Gene

  • Protein details for NADK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0N4-NAKD2_HUMAN
    Recommended name:
    NAD kinase 2, mitochondrial
    Protein Accession:
    Q4G0N4
    Secondary Accessions:
    • B5MC93
    • Q6UTX5
    • Q96NM0

    Protein attributes for NADK2 Gene

    Size:
    442 amino acids
    Molecular mass:
    49433 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for NADK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NADK2 Gene

Proteomics data for NADK2 Gene at MOPED

Post-translational modifications for NADK2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys104

No data available for DME Specific Peptides for NADK2 Gene

Domains for NADK2 Gene

UniProtKB/Swiss-Prot:

NAKD2_HUMAN
Family:
  • Belongs to the NAD kinase family.:
    • Q4G0N4
genes like me logo Genes that share domains with NADK2: view

No data available for Gene Families for NADK2 Gene

Function for NADK2 Gene

Molecular function for NADK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.022 mM for NAD(+) {ECO:0000269 PubMed:23212377}; KM=1.7 mM for ATP {ECO:0000269 PubMed:23212377}; KM=1.2 mM for tetrapolyphosphate {ECO:0000269 PubMed:23212377}; Vmax=0.091 umol/min/mg enzyme {ECO:0000269 PubMed:23212377};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + NAD(+) = ADP + NADP(+).
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by NADH, NADPH and NADP(+).
UniProtKB/Swiss-Prot Function: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.

Enzyme Numbers (IUBMB) for NADK2 Gene

Gene Ontology (GO) - Molecular Function for NADK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IDA 23212377
GO:0005524 ATP binding IEA --
GO:0042803 protein homodimerization activity IDA 23212377
genes like me logo Genes that share ontologies with NADK2: view

miRNA for NADK2 Gene

miRTarBase miRNAs that target NADK2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NADK2 Gene

Localization for NADK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NADK2 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for NADK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23212377
genes like me logo Genes that share ontologies with NADK2: view

Pathways for NADK2 Gene

SuperPathways for NADK2 Gene

No Data Available

Interacting Proteins for NADK2 Gene

Gene Ontology (GO) - Biological Process for NADK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006741 NADP biosynthetic process IEA --
GO:0008152 metabolic process --
GO:0016310 phosphorylation IEA --
GO:0019674 NAD metabolic process IDA 23212377
genes like me logo Genes that share ontologies with NADK2: view

No data available for Pathways by source for NADK2 Gene

Transcripts for NADK2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NADK2 Gene

No ASD Table

Relevant External Links for NADK2 Gene

GeneLoc Exon Structure for
NADK2
ECgene alternative splicing isoforms for
NADK2

Expression for NADK2 Gene

mRNA expression in normal human tissues for NADK2 Gene

mRNA differential expression in normal tissues according to GTEx for NADK2 Gene

This gene is overexpressed in Liver (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NADK2 Gene

mRNA Expression by UniProt/SwissProt for NADK2 Gene

Q4G0N4-NAKD2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with NADK2: view

Orthologs for NADK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NADK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NADK2 37
  • 100 (a)
OneToOne
NADKD1 36
  • 99.7 (n)
  • 99.55 (a)
cow
(Bos Taurus)
Mammalia NADK2 37
  • 91 (a)
OneToOne
NADKD1 36
  • 91.78 (n)
  • 95.7 (a)
dog
(Canis familiaris)
Mammalia NADK2 36
  • 93.51 (n)
  • 96.61 (a)
mouse
(Mus musculus)
Mammalia Nadk2 36
  • 89.22 (n)
  • 94.65 (a)
Nadk2 37
  • 90 (a)
OneToOne
Nadkd1 16
oppossum
(Monodelphis domestica)
Mammalia NADK2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NADK2 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nadk2 36
  • 89.4 (n)
  • 96.18 (a)
chicken
(Gallus gallus)
Aves NADK2 37
  • 74 (a)
OneToOne
NADKD1 36
  • 79.09 (n)
  • 83.8 (a)
lizard
(Anolis carolinensis)
Reptilia NADK2 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2638 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nadk2 36
  • 72.07 (n)
  • 76.6 (a)
Str.11200 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7246 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13238 36
nadk2 36
  • 66.43 (n)
  • 73.38 (a)
nadk2 37
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006767 36
  • 46.75 (n)
  • 40.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8080 36
  • 46.65 (n)
  • 38.34 (a)
CG8080 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.10 36
  • 51.25 (n)
  • 47.06 (a)
Y17G7B.10 37
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToMany
CSA.2100 37
  • 42 (a)
OneToMany
Species with no ortholog for NADK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NADK2 Gene

ENSEMBL:
Gene Tree for NADK2 (if available)
TreeFam:
Gene Tree for NADK2 (if available)

Paralogs for NADK2 Gene

Selected SIMAP similar genes for NADK2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NADK2 Gene

genes like me logo Genes that share paralogs with NADK2: view

No data available for Paralogs for NADK2 Gene

Variants for NADK2 Gene

Sequence variations from dbSNP and Humsavar for NADK2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs991032 -- 36,209,860(+) CATGA(G/T)GTATT intron-variant
rs991033 -- 36,209,973(+) AGTCA(C/T)TGGCT intron-variant
rs991034 -- 36,210,293(+) TCCAC(A/C)AAAAT intron-variant
rs1364013 -- 36,218,037(+) ATAGC(C/T)TCCTT intron-variant
rs1364014 -- 36,218,229(+) AAAGC(A/T)TTCTT intron-variant

Relevant External Links for NADK2 Gene

HapMap Linkage Disequilibrium report
NADK2
Human Gene Mutation Database (HGMD)
NADK2

No data available for Structural Variations from Database of Genomic Variants (DGV) for NADK2 Gene

Disorders for NADK2 Gene

UniProtKB/Swiss-Prot

NAKD2_HUMAN
  • 2,4-dienoyl-CoA reductase deficiency (DECRD) [MIM:616034]: A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia. {ECO:0000269 PubMed:24847004}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with NADK2: view

Publications for NADK2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification and characterization of a human mitochondrial NAD kinase. (PMID: 23212377) Ohashi K. … Murata K. (Nat. Commun. 2012) 3 4
  3. MNADK, a novel liver-enriched mitochondrion-localized NAD kinase. (PMID: 23616928) Zhang R. (Biol Open 2013) 2 3
  4. Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia. (PMID: 24847004) Houten S.M. … Wanders R.J. (Hum. Mol. Genet. 2014) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for NADK2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NADK2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NADK2
    • Block miRNA regulation of NADK2 using miScript Target Protectors

    Sources for NADK2 Gene

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