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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NADK Gene

protein-coding   GIFtS: 65
GCID: GC01M001682

NAD kinase

 Explore 4 diseases affiliated with
NADK via our new
 Human Malady Compendium 
Biological research products
for NADK
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NAD Kinase1 2
Poly(P)/ATP NAD Kinase2 3
EC 2.7.1.233 8
FLJ130521
DJ283E3.11
EC 2.7.18

External Ids:    HGNC: 298311   Entrez Gene: 652202   Ensembl: ENSG000000081307   OMIM: 6116165   UniProtKB: O955443   

Export aliases for NADK gene to outside databases

Previous GC identifers: GC01M001715 GC01M000958


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NADK:
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an
electron donor for biosynthetic reactions (Lerner et al., 2001 (PubMed 11594753)).(supplied by OMIM, Mar 2008)

Gene Wiki entry for NADK (NAD+ kinase)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NADK gene promoter:
         HOXA9   Egr-3   Sox5   USF1   Evi-1   Egr-2   HSF2   USF-1   ARP-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNADK promoter sequence
   Search SABiosciences Chromatin IP Primers for NADK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NADK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

NADK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NADK gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001682:  view genomic region     (about GC identifiers)

Start:
1,682,671 bp from pter      End:
1,711,896 bp from pter
Size:
29,226 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NADK_HUMAN, O95544 (See protein sequence)
Recommended Name: NAD kinase  
Size: 446 amino acids; 49228 Da
Cofactor: Divalent metal cations
1 PDB 3D structure from and Proteopedia for NADK:
3PFN (3D)    
Secondary accessions: A8K296 Q9H931

Explore the universe of human proteins at neXtProt for NADK: NX_O95544

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95544

  • 4/6 DME Specific Peptides for NADK (O95544) (see all 6)
     GGDGTLL  PTGSTAY  PICPHSL  STPTGSTAY 

    NADK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001185922.1  NP_001185923.1  NP_001185924.1  NP_075394.3  

    ENSEMBL proteins: 
     ENSP00000341679   ENSP00000344340   ENSP00000367890   ENSP00000464137   ENSP00000462589  
     ENSP00000462999   ENSP00000464096   ENSP00000383713   ENSP00000340925   ENSP00000339727  
    Reactome Protein details: O95544
    Human Recombinant Protein Products: 
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    Enzo Life Sciences proteins for NADK
    OriGene Purified Protein: NADK
    OriGene Protein Over-expression Lysate: NADK
    OriGene Custom Protein Services for NADK 
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    Novus Biologicals NADK Proteins
    Novus Biologicals NADK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NADK

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    NADK for ontologies           About GeneDecksing



    NADK Antibody Products: 
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    Uscn ELISAs and CLIAs for NADK


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NADK for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002504 PolyP/ATP_NADK_prd
     IPR017437 ATP-NAD_kinase_PpnK-typ_all-b
     IPR017438 ATP-NAD_kinase_dom_1
     IPR016064 ATP-NAD_kinase_PpnK-typ

    Graphical View of Domain Structure for InterPro Entry O95544

    ProtoNet protein and cluster: O95544

    1 Blocks protein family: IPB002504 ATP-NAD kinase

    UniProtKB/Swiss-Prot: NADK_HUMAN, O95544
    Similarity: Belongs to the NAD kinase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NADK_HUMAN, O95544
    Catalytic activity: ATP + NAD(+) = ADP + NADP(+)
    Biophysicochemical properties: Kinetic parameters: KM=3.3 mM for ATP; KM=0.54 mM for NAD; Vmax=6.7 umol/min/mg enzyme;
    pH dependence: Optimum pH is 7.5; Temperature dependence: Optimum temperature is 55 degrees Celsius;

    Enzyme Numbers (IUBMB): EC 2.7.1.231 2 EC 2.7.12

    miRNA
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    hsa-miR-30c hsa-miR-488 hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-29a* hsa-miR-3915 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidNADK 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NADK (see all 7)
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    OriGene siRNA: NADK
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NADK

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity TAS--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--


    NADK for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NADK:
     Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Nadk (no phenotypes)

    NADK for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    NAD metabolism1.00
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism1.00
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3Vitamin B5 (pantothenate) metabolism
    Metabolism of vitamins and cofactors0.21
    Metabolism of water-soluble vitamins and cofactors0.21
    4Nicotinate metabolism
    Nicotinate metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NADK
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for NADK
        NAD metabolism

    4        Reactome Pathways for NADK
        Nicotinate metabolism
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    2         Kegg Pathways  (Kegg details for NADK):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways


    NADK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NADK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/38 Interacting proteins for NADK (O955442, 3 ENSP000003416794) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3296408 I2D: score=3 STRING: ENSP00000309503
    LNX1Q8TBB13, ENSP000002639254I2D: score=4 STRING: ENSP00000263925
    GLRX3O760033, ENSP000003308364I2D: score=4 STRING: ENSP00000330836
    NUDT18Q6ZVK83, ENSP000003078524I2D: score=4 STRING: ENSP00000307852
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006741NADP biosynthetic process IEA--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0016310phosphorylation NAS11594753
    GO:0019674NAD metabolic process TAS--


    NADK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NADK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NADK

    5 HMDB Compounds for NADK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    6 Novoseek chemical compound relationships for NADK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadp+ 77.2 2 15855156 (1), 16682646 (1)
    nad+ 69.1 6 15855156 (2), 17258457 (1), 16682646 (1)
    nadph 60.2 4 19430699 (2), 17855339 (1), 16244906 (1)
    nadh 53 11 15855156 (6), 19430699 (2)
    atp 26.3 3 19430699 (1), 15247403 (1), 16244906 (1)
    calcium 9.01 2 19639701 (1), 2154300 (1)

    Search CenterWatch for drugs/clinical trials and news about NADK 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NADK gene (4 alternative transcripts): 
    NM_001198993.1  NM_001198994.1  NM_001198995.1  NM_023018.4  

    Unigene Cluster for NADK:

    NAD kinase
    Hs.654792  [show with all ESTs]
    Unigene Representative Sequence: AF250320
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000341426(uc001aic.3) ENST00000341991(uc010nyv.2 uc001aid.4)
    ENST00000378625(uc009vkx.1 uc001aie.3) ENST00000498806 ENST00000469045
    ENST00000480499 ENST00000497747 ENST00000477235 ENST00000489538 ENST00000497615
    ENST00000497186 ENST00000400922 ENST00000492845 ENST00000492768 ENST00000460602
    ENST00000464373 ENST00000480542 ENST00000344463

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate NADK (see all 19):
    hsa-miR-30c hsa-miR-488 hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-29a* hsa-miR-3915 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidNADK 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NADK (see all 7)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NADK

    Additional cDNA sequence: 

    AF070630.1 AF250320.1 AK023114.1 AK290161.1 AK291599.1 AK291728.1 AK296722.1 AY090771.1 
    BC001709.1 BC022063.2 BC024219.1 

    20 DOTS entries:

    DT.100812649  DT.419736  DT.100812651  DT.100812650  DT.100812658  DT.121399108  DT.97836870  DT.121399209 
    DT.95340380  DT.95340417  DT.92007756  DT.100649583  DT.100811850  DT.121399055  DT.91964138  DT.121399236 
    DT.91771510  DT.97859560  DT.100812646  DT.40193627 

    24/454 AceView cDNA sequences (see all 454):

    CD369910 BF198071 AY090771 BU956383 AI305152 BM773209 AW005305 AI184247 
    CF264721 AI871979 BM553002 BU195659 CD368762 BM975968 AI288504 AI421355 
    CD369878 CB156624 Z39111 BG232029 AI816996 BQ712146 BF591301 AI582479 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NADK (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^
    SP1:                                            -     -                       -     -     -                       -     -     -                                 
    SP2:                                                  -                       -     -     -                       -     -     -                                 
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:  -                             -                                 
    SP2:  -                             -                                 
    SP3:  -                             -                                 
    SP4:  -                                                               
    SP5:  -                             -     -     -                     


    ECgene alternative splicing isoforms for NADK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NADK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCTGGGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NADK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NADK

    SOURCE GeneReport for Unigene cluster: Hs.654792

    UniProtKB/Swiss-Prot: NADK_HUMAN, O95544
    Tissue specificity: Widely expressed but not detected in skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NADK gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nadk1 , 5 NAD kinase1, 5 85.89(n)1
    93.14(a)1
      4 (86.44 cM)5
    1921851  NM_001159637.11  NP_001153109.11 
     1555623785 
    chicken
    (Gallus gallus)
    Aves NADK1 NAD kinase 75.04(n)
    86.53(a)
      419403  NM_001030870.1  NP_001026041.1 
    lizard
    (Anolis carolinensis)
    Reptilia NADK6
    --
    73(a)
    1 ↔ 1
    AAWZ02037388(10052-15642)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC059316.12   -- 78.66(n)    BC059316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nadka1 NAD kinase a 69.94(n)
    75(a)
      550242  NM_001017580.1  NP_001017580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331561 CG33156 61.31(n)
    62.24(a)
      36507  NM_176166.2  NP_788346.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NADK21 NAD kinase 2 52.92(n)
    49.03(a)
      838766  NM_102013.4  NP_564145.1 
    rice
    (Oryza sativa)
    Liliopsida Os.172822 Oryza sativa (japonica cultivar-group) cDNA cloneJ033032H18, full insert sequence less 69.11(n)    AK060751.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria nadK6
    NAD kinase
    26(a)
    1 ↔ 1
    Chromosome(2748853-2749731)


    ENSEMBL Gene Tree for NADK (if available)
    TreeFam Gene Tree for NADK (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/551 NCBI SNPs in NADK are shown (see all 551    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563104081,2
    C--1682374(+) GCCCCA/GGGAAT 4 -- int10--------
    rs88411,2
    C--1683420(-) GCAACT/AGTAAT 4 -- ut315Minor allele frequency- A:0.36MN NA 560
    rs171628461,2
    C,F--1683565(+) CAGACG/AACTCC 4 -- ut31 ese34Minor allele frequency- A:0.43MN NA 190
    rs1458320401,2
    --1683599(+) AGTGTA/GTACGA 4 -- ut310--------
    rs1489526751,2
    --1683655(+) AAAAGC/TATATA 4 -- ut310--------
    rs1437361331,2
    --1683868(+) TTTCAA/GTGGCG 4 -- ut310--------
    rs10620901,2
    C,--1683900(-) TAAAAC/TTTCTG 4 -- ut31 ese35Minor allele frequency- T:0.28NA WA EA 362
    rs1823152371,2
    --1684037(+) TTTGCA/GGAAAA 4 -- ut310--------
    rs22355341,2
    C,--1684063(+) AATTGC/TGGCAG 4 -- ut31 ese34Minor allele frequency- T:0.13CSA WA EA 241
    rs77961,2
    C,F,--1684169(-) AAAATG/CTCTGA 4 -- ut318Minor allele frequency- C:0.42MN NA EA 434

    HapMap Linkage Disequilibrium report for NADK (1682671 - 1711896 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for NADK
         7 CNVs: 0002 22925 31596 2295 63709 30362 3276

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NADK for disorders           About GeneDecksing

    OMIM gene information: 611616    OMIM disorders: --

    4 diseases for NADK:    About MalaCards
    dental caries    tuberculosis    pneumonia    mycobacterium tuberculosis

    1 Novoseek disease relationship for NADK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 43.3 6 15269221 (1), 19596199 (1), 17258457 (1)

    Human Genome Epidemiology (HuGE) Navigator: NADK (1 document)

    Export disorders for NADK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NADK gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with NADK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of human NAD kinase. (PubMed id 11594753)1, 2, 3, 9 Lerner F.... Ziegler M. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. NAD kinase levels control the NADPH concentration in human cells. (PubMed id 17855339)1, 9 Pollak N....Ziegler M. (2007)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. NADPH regulates human NAD kinase, a NADPa8_-biosyntheti c enzyme. (PubMed id 21526340)1 Ohashi K....Murata K. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65220 HGNC: 29831 AceView: FLJ13052 Ensembl:ENSG00000008130 euGenes: HUgn65220
    ECgene: NADK Kegg: 65220 H-InvDB: NADK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NADK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NADK gene:
    Search GeneIP for patents involving NADK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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