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Aliases for NADK Gene

Aliases for NADK Gene

  • NAD Kinase 2 3 5
  • Poly(P)/ATP NAD Kinase 3 4
  • EC 2.7.1.23 4 63
  • DJ283E3.1 3
  • EC 2.7.1 63

External Ids for NADK Gene

Previous GeneCards Identifiers for NADK Gene

  • GC01M001715
  • GC01M000958
  • GC01M001682

Summaries for NADK Gene

Entrez Gene Summary for NADK Gene

  • NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NADK Gene

NADK (NAD Kinase) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. GO annotations related to this gene include NAD+ kinase activity.

Gene Wiki entry for NADK Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NADK Gene

Genomics for NADK Gene

Regulatory Elements for NADK Gene

Enhancers for NADK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NADK on UCSC Golden Path with GeneCards custom track

Promoters for NADK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NADK on UCSC Golden Path with GeneCards custom track

Genomic Location for NADK Gene

Chromosome:
1
Start:
1,751,232 bp from pter
End:
1,780,514 bp from pter
Size:
29,283 bases
Orientation:
Minus strand

Genomic View for NADK Gene

Genes around NADK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NADK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NADK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADK Gene

Proteins for NADK Gene

  • Protein details for NADK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95544-NADK_HUMAN
    Recommended name:
    NAD kinase
    Protein Accession:
    O95544
    Secondary Accessions:
    • A6NNN3
    • A8K296
    • B7Z434
    • F5GXR5
    • Q5QPS4
    • Q9H2P2
    • Q9H931

    Protein attributes for NADK Gene

    Size:
    446 amino acids
    Molecular mass:
    49228 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NADK Gene

    Alternative splice isoforms for NADK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NADK Gene

Proteomics data for NADK Gene at MOPED

Selected DME Specific Peptides for NADK Gene

Post-translational modifications for NADK Gene

  • Ubiquitination at Lys 57
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PPNK

Domains & Families for NADK Gene

Suggested Antigen Peptide Sequences for NADK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95544

UniProtKB/Swiss-Prot:

NADK_HUMAN :
  • Belongs to the NAD kinase family.
Family:
  • Belongs to the NAD kinase family.
genes like me logo Genes that share domains with NADK: view

No data available for Gene Families for NADK Gene

Function for NADK Gene

Molecular function for NADK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.3 mM for ATP {ECO:0000269 PubMed:11594753}; KM=0.54 mM for NAD {ECO:0000269 PubMed:11594753}; Vmax=6.7 umol/min/mg enzyme {ECO:0000269 PubMed:11594753}; pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:11594753}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269 PubMed:11594753};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + NAD(+) = ADP + NADP(+).

Enzyme Numbers (IUBMB) for NADK Gene

Gene Ontology (GO) - Molecular Function for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity TAS --
genes like me logo Genes that share ontologies with NADK: view
genes like me logo Genes that share phenotypes with NADK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NADK

miRNA for NADK Gene

miRTarBase miRNAs that target NADK

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NADK Gene

Localization for NADK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NADK Gene COMPARTMENTS Subcellular localization image for NADK gene
Compartment Confidence
cytosol 5
nucleus 3
chloroplast 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NADK Gene

Pathways & Interactions for NADK Gene

genes like me logo Genes that share pathways with NADK: view

Pathways by source for NADK Gene

Gene Ontology (GO) - Biological Process for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006741 NADP biosynthetic process IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0016310 phosphorylation IEA,NAS 11594753
GO:0019674 NAD metabolic process IEA,TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NADK: view

No data available for SIGNOR curated interactions for NADK Gene

Drugs & Compounds for NADK Gene

(5) Drugs for NADK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
NADH Nutra 0
NAD Pharma Full agonist, Agonist 0

(5) Additional Compounds for NADK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with NADK: view

Transcripts for NADK Gene

Unigene Clusters for NADK Gene

NAD kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NADK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5:
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15:
SP16:

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NADK Gene

GeneLoc Exon Structure for
NADK
ECgene alternative splicing isoforms for
NADK

Expression for NADK Gene

mRNA expression in normal human tissues for NADK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NADK Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for NADK Gene

This gene is overexpressed in Monocytes (23.2), Blymphocyte (11.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NADK Gene



SOURCE GeneReport for Unigene cluster for NADK Gene Hs.654792

mRNA Expression by UniProt/SwissProt for NADK Gene

O95544-NADK_HUMAN
Tissue specificity: Widely expressed but not detected in skeletal muscle.
genes like me logo Genes that share expression patterns with NADK: view

Protein tissue co-expression partners for NADK Gene

- Elite partner

Primer Products

Orthologs for NADK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NADK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NADK 35
  • 86.18 (n)
  • 90.09 (a)
NADK 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NADK 35
  • 86.77 (n)
  • 92.2 (a)
NADK 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nadk 35
  • 86.08 (n)
  • 93.74 (a)
Nadk 16
Nadk 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NADK 35
  • 99.39 (n)
  • 99.54 (a)
NADK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nadk 35
  • 86.16 (n)
  • 93.74 (a)
oppossum
(Monodelphis domestica)
Mammalia NADK 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NADK 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves NADK 35
  • 75.29 (n)
  • 86.84 (a)
NADK 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NADK 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nadk 35
  • 72.81 (n)
  • 80.65 (a)
zebrafish
(Danio rerio)
Actinopterygii nadka 35
  • 70.22 (n)
  • 75.36 (a)
nadka 36
  • 51 (a)
OneToMany
nadka 36
  • 78 (a)
OneToMany
nadkb 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011122 35
  • 46.02 (n)
  • 33.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33156 35
  • 61.5 (n)
  • 62.79 (a)
CG33156 36
  • 50 (a)
OneToMany
CG6145 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTR1 36
  • 25 (a)
OneToMany
YEF1 36
  • 29 (a)
OneToMany
UTR1 38
rice
(Oryza sativa)
Liliopsida Os.17282 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3H5.11 35
  • 46.62 (n)
  • 39.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for NADK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NADK Gene

ENSEMBL:
Gene Tree for NADK (if available)
TreeFam:
Gene Tree for NADK (if available)

Paralogs for NADK Gene

(1) SIMAP similar genes for NADK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NADK: view

No data available for Paralogs for NADK Gene

Variants for NADK Gene

Sequence variations from dbSNP and Humsavar for NADK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4751 - 1,754,601(-) GAGAA(A/C/G)GGCTC nc-transcript-variant, reference, missense
rs7407 -- 1,753,033(-) TACCC(A/G)CTCCC nc-transcript-variant, reference, synonymous-codon
rs7796 -- 1,752,730(-) AAAAT(C/G)TCTGA nc-transcript-variant, utr-variant-3-prime
rs454577 -- 1,782,275(+) CCAGG(G/T)CCGGC upstream-variant-2KB
rs876029 -- 1,764,135(-) GCAGC(A/C)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NADK Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
esv27786 CNV Gain 19812545
dgv10e1 CNV Complex 17122850
nsv482957 CNV Loss 15286789
dgv52n71 CNV Loss 21882294
dgv53n71 CNV Gain 21882294
nsv871560 CNV Loss 21882294
nsv436343 CNV Deletion 17901297
nsv834091 CNV Loss 17160897
nsv871903 CNV Gain+Loss 21882294
nsv871121 CNV Gain 21882294
essv725 CNV CNV 17122850
nsv870637 CNV Loss 21882294
esv2749807 CNV Deletion 23290073
esv2749918 CNV Deletion 23290073
dgv54n71 CNV Loss 21882294

Variation tolerance for NADK Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NADK Gene

Disorders for NADK Gene

Relevant External Links for NADK

Genetic Association Database (GAD)
NADK
Human Genome Epidemiology (HuGE) Navigator
NADK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NADK

No disorders were found for NADK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NADK Gene

Publications for NADK Gene

  1. Structural and functional characterization of human NAD kinase. (PMID: 11594753) Lerner F. … Ziegler M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. NAD kinase levels control the NADPH concentration in human cells. (PMID: 17855339) Pollak N. … Ziegler M. (J. Biol. Chem. 2007) 3 23
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions. (PMID: 26577408) Kawabata Y. … Kawai S. (Biochem. Biophys. Res. Commun. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NADK Gene

Sources for NADK Gene

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