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Aliases for NADK Gene

Aliases for NADK Gene

  • NAD Kinase 2 3 5
  • Poly(P)/ATP NAD Kinase 3 4
  • EC 2.7.1.23 4 61
  • DJ283E3.1 3
  • EC 2.7.1 61

External Ids for NADK Gene

Previous GeneCards Identifiers for NADK Gene

  • GC01M001715
  • GC01M000958
  • GC01M001682

Summaries for NADK Gene

Entrez Gene Summary for NADK Gene

  • NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NADK Gene

NADK (NAD Kinase) is a Protein Coding gene. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include NAD+ kinase activity.

Gene Wiki entry for NADK Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NADK Gene

Genomics for NADK Gene

Regulatory Elements for NADK Gene

Enhancers for NADK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G001775 1.7 FANTOM5 ENCODE dbSUPER 39.2 +1.0 989 8.6 HDGF PKNOX1 FOXA2 ARNT CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A NADK ENSG00000240731 CCNL2 LOC100288379 LOC105378949 ENSG00000230092 FAM87B LINC00115 TMEM52 LOC100129381
GH01G002150 1.5 FANTOM5 Ensembl ENCODE dbSUPER 30.3 -371.3 -371250 3.1 CTCF NRF1 CEBPB MAX CEBPG ZBTB7A SMARCA4 POLR2A SCRT2 MYC NADK FAAP20 PRKCZ-AS1 ENSG00000271806 LOC105378589 CDK11A CDK11B TNFRSF14 GNB1 SKI
GH01G002239 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -459.8 -459835 1.3 KLF1 NFIB SIN3A MAX ZIC2 RAD21 ZFHX2 GLIS2 EGR1 PATZ1 NADK SKI TNFRSF14 GNB1 PANK4 PIR45792
GH01G002245 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8 -468.6 -468598 6.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 CBX5 MORN1 LOC100129534 LINC01786 ENSG00000240731 ENSG00000272455 SLC35E2 MIB2 CCNL2 SLC35E2B LOC100129381
GH01G001880 0.8 ENCODE dbSUPER 6.8 -101.2 -101169 2.0 GATAD2A ZNF316 POLR2A ZNF600 EMSY MAFK LOC105378949 TMEM52 NADK GC01P001881
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NADK on UCSC Golden Path with GeneCards custom track

Genomic Location for NADK Gene

Chromosome:
1
Start:
1,751,232 bp from pter
End:
1,780,514 bp from pter
Size:
29,283 bases
Orientation:
Minus strand

Genomic View for NADK Gene

Genes around NADK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NADK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NADK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NADK Gene

Proteins for NADK Gene

  • Protein details for NADK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95544-NADK_HUMAN
    Recommended name:
    NAD kinase
    Protein Accession:
    O95544
    Secondary Accessions:
    • A6NNN3
    • A8K296
    • B7Z434
    • F5GXR5
    • Q5QPS4
    • Q9H2P2
    • Q9H931

    Protein attributes for NADK Gene

    Size:
    446 amino acids
    Molecular mass:
    49228 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NADK Gene

    Alternative splice isoforms for NADK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NADK Gene

Selected DME Specific Peptides for NADK Gene

O95544:
  • ICPHSLSFRP
  • STPTGSTAY
  • IVSTPTGST
  • GGDGTLL
  • PTGSTAY
  • PICPHSL

Post-translational modifications for NADK Gene

  • Ubiquitination at posLast=5757
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NADK
  • Santa Cruz Biotechnology (SCBT) Antibodies for NADK

Domains & Families for NADK Gene

Suggested Antigen Peptide Sequences for NADK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95544

UniProtKB/Swiss-Prot:

NADK_HUMAN :
  • Belongs to the NAD kinase family.
Family:
  • Belongs to the NAD kinase family.
genes like me logo Genes that share domains with NADK: view

No data available for Gene Families for NADK Gene

Function for NADK Gene

Molecular function for NADK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.3 mM for ATP {ECO:0000269 PubMed:11594753}; KM=0.54 mM for NAD {ECO:0000269 PubMed:11594753}; Vmax=6.7 umol/min/mg enzyme {ECO:0000269 PubMed:11594753}; pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:11594753}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269 PubMed:11594753};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + NAD(+) = ADP + NADP(+).

Enzyme Numbers (IUBMB) for NADK Gene

Gene Ontology (GO) - Molecular Function for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NADK: view
genes like me logo Genes that share phenotypes with NADK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NADK

CRISPR Products

miRNA for NADK Gene

miRTarBase miRNAs that target NADK

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NADK Gene

Localization for NADK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NADK gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 11594753
genes like me logo Genes that share ontologies with NADK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NADK Gene

Pathways & Interactions for NADK Gene

genes like me logo Genes that share pathways with NADK: view

Pathways by source for NADK Gene

1 GeneGo (Thomson Reuters) pathway for NADK Gene

Gene Ontology (GO) - Biological Process for NADK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006741 NADP biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA,NAS 11594753
GO:0019674 NAD metabolic process TAS,IEA --
GO:0046034 ATP metabolic process NAS 11594753
genes like me logo Genes that share ontologies with NADK: view

No data available for SIGNOR curated interactions for NADK Gene

Drugs & Compounds for NADK Gene

(5) Drugs for NADK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
NADH Nutra 0
NAD Pharma Full agonist, Agonist 0

(5) Additional Compounds for NADK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with NADK: view

Transcripts for NADK Gene

Unigene Clusters for NADK Gene

NAD kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NADK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5:
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15:
SP16:

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NADK Gene

GeneLoc Exon Structure for
NADK
ECgene alternative splicing isoforms for
NADK

Expression for NADK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NADK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NADK Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for NADK Gene

This gene is overexpressed in Monocytes (23.2), Blymphocyte (11.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NADK Gene



Protein tissue co-expression partners for NADK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NADK Gene:

NADK

SOURCE GeneReport for Unigene cluster for NADK Gene:

Hs.654792

mRNA Expression by UniProt/SwissProt for NADK Gene:

O95544-NADK_HUMAN
Tissue specificity: Widely expressed but not detected in skeletal muscle.

Evidence on tissue expression from TISSUES for NADK Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with NADK: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NADK Gene

Orthologs for NADK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NADK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NADK 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia NADK 35 34
  • 86.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NADK 35 34
  • 86.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nadk 34
  • 86.16 (n)
mouse
(Mus musculus)
Mammalia Nadk 34 16 35
  • 86.08 (n)
oppossum
(Monodelphis domestica)
Mammalia NADK 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NADK 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves NADK 35 34
  • 75.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NADK 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nadk 34
  • 72.81 (n)
zebrafish
(Danio rerio)
Actinopterygii nadka 34 35 35
  • 70.22 (n)
nadkb 35
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG33156 34 35
  • 61.5 (n)
CG6145 35
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011122 34
  • 46.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEF1 35
  • 29 (a)
OneToMany
UTR1 35 37
  • 25 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.17282 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3H5.11 34
  • 46.62 (n)
Species where no ortholog for NADK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NADK Gene

ENSEMBL:
Gene Tree for NADK (if available)
TreeFam:
Gene Tree for NADK (if available)

Paralogs for NADK Gene

(1) SIMAP similar genes for NADK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NADK: view

No data available for Paralogs for NADK Gene

Variants for NADK Gene

Sequence variations from dbSNP and Humsavar for NADK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000157898 -- 1,774,163(+) GTGTG(-/TA)TATAT intron-variant
rs1000297994 -- 1,758,792(+) TAACT(-/G)AGCCG intron-variant, upstream-variant-2KB
rs1000335089 -- 1,776,271(+) CTCCA(A/C)AAGAA intron-variant
rs1000388683 -- 1,766,959(+) GCCCA(C/T)GCTGG intron-variant
rs1000417048 -- 1,774,293(+) TGGCG(C/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NADK Gene

Variant ID Type Subtype PubMed ID
dgv10n100 CNV gain 25217958
dgv3e212 CNV loss 25503493
dgv42n54 CNV loss 21841781
dgv4e212 CNV gain 25503493
dgv5e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv9n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv1160926 CNV duplication 26073780
nsv436343 CNV deletion 17901297
nsv482937 CNV loss 15286789
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv545041 CNV loss 21841781
nsv834091 CNV loss 17160897
nsv945749 CNV duplication 23825009
nsv950521 CNV deletion 24416366

Variation tolerance for NADK Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NADK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NADK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NADK Gene

Disorders for NADK Gene

Relevant External Links for NADK

Genetic Association Database (GAD)
NADK
Human Genome Epidemiology (HuGE) Navigator
NADK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NADK

No disorders were found for NADK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NADK Gene

Publications for NADK Gene

  1. Structural and functional characterization of human NAD kinase. (PMID: 11594753) Lerner F. … Ziegler M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. NAD kinase levels control the NADPH concentration in human cells. (PMID: 17855339) Pollak N. … Ziegler M. (J. Biol. Chem. 2007) 3 22 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NADK Gene

Sources for NADK Gene

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