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NADK Gene

protein-coding   GIFtS: 69
GCID: GC01M001682

NAD Kinase

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NAD Kinase1 2
Poly(P)/ATP NAD Kinase2 3
EC 2.7.1.233 8
dJ283E3.12
EC 2.7.18

External Ids:    HGNC: 298311   Entrez Gene: 652202   Ensembl: ENSG000000081307   OMIM: 6116165   UniProtKB: O955443   

Export aliases for NADK gene to outside databases

Previous GC identifers: GC01M001715 GC01M000958


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NADK Gene:
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts
as an electron donor for biosynthetic reactions (Lerner et al., 2001 (PubMed 11594753)).(supplied by OMIM, Mar
2008)

GeneCards Summary for NADK Gene:
NADK (NAD kinase) is a protein-coding gene. Diseases associated with NADK include dental caries, and tuberculosis. GO annotations related to this gene include NAD+ kinase activity.

Gene Wiki entry for NADK (NAD+ kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NADK gene promoter:
         HOXA9   Egr-3   Sox5   USF1   Evi-1   Egr-2   HSF2   USF-1   ARP-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNADK promoter sequence
   Search Chromatin IP Primers for NADK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NADK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

NADK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NADK gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001682:  view genomic region     (about GC identifiers)

Start:
1,682,671 bp from pter      End:
1,711,896 bp from pter
Size:
29,226 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NADK_HUMAN, O95544 (See protein sequence)
Recommended Name: NAD kinase  
Size: 446 amino acids; 49228 Da
Cofactor: Divalent metal cations
1 PDB 3D structure from and Proteopedia for NADK:
3PFN (3D)    
Secondary accessions: A6NNN3 A8K296 B7Z434 F5GXR5 Q5QPS4 Q9H2P2 Q9H931
Alternative splicing: 3 isoforms:  O95544-1   O95544-2   O95544-3   

Explore the universe of human proteins at neXtProt for NADK: NX_O95544

Explore proteomics data for NADK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys57
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NADK (O95544) (see all 6)
     GGDGTLL  PTGSTAY  PICPHSL  STPTGSTAY 


    See NADK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001185922.1  NP_001185923.1  NP_001185924.1  NP_075394.3  

    ENSEMBL proteins: 
     ENSP00000341679   ENSP00000344340   ENSP00000367890   ENSP00000464137   ENSP00000462589  
     ENSP00000462999   ENSP00000464096   ENSP00000383713   ENSP00000340925   ENSP00000339727  
    Reactome Protein details: O95544

    NADK Human Recombinant Protein Products:

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    Novus Biologicals NADK Proteins
    Novus Biologicals NADK Lysates
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    Cloud-Clone Corp. Proteins for NADK

    NADK Antibody Products:

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    LSBio Antibodies in human, mouse, rat for NADK

    NADK Assay Products:

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    Cloud-Clone Corp. ELISAs for NADK
    Cloud-Clone Corp. CLIAs for NADK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002504 PolyP/ATP_NADK_prd
     IPR017437 ATP-NAD_kinase_PpnK-typ_all-b
     IPR017438 ATP-NAD_kinase_dom_1
     IPR016064 ATP-NAD_kinase_PpnK-typ

    Graphical View of Domain Structure for InterPro Entry O95544

    ProtoNet protein and cluster: O95544

    1 Blocks protein domain: IPB002504 ATP-NAD kinase

    UniProtKB/Swiss-Prot: NADK_HUMAN, O95544
    Similarity: Belongs to the NAD kinase family


    NADK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NADK_HUMAN, O95544
    Catalytic activity: ATP + NAD(+) = ADP + NADP(+)
    Biophysicochemical properties: Kinetic parameters: KM=3.3 mM for ATP; KM=0.54 mM for NAD; Vmax=6.7 umol/min/mg
    enzyme; pH dependence: Optimum pH is 7.5; Temperature dependence: Optimum temperature is 55 degrees Celsius;

         Enzyme Numbers (IUBMB): EC 2.7.1.231 2 EC 2.7.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003951NAD+ kinase activity TAS--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
         
    NADK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NADK:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Nadk (no phenotypes)

    NADK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NADK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NADK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NADK

    miRNA
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    miRTarBase miRNAs that target NADK:
    hsa-mir-92a-3p (MIRT049675), hsa-mir-425-5p (MIRT039348)

    Block miRNA regulation of human, mouse, rat NADK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NADK (see all 19):
    hsa-miR-30c hsa-miR-488 hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-29a* hsa-miR-3915 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidNADK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NADK

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): NADK (NM_023018)
    Sino Biological Human cDNA Clone for NADK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NADK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NADK

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NADK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS11594753

    NADK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NADK About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    Nicotinate metabolism0.00
    NAD metabolism0.43
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Metabolism of vitamins and cofactors1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NADK
        NAD metabolism


    1 Reactome Pathway for NADK
        Nicotinate metabolism


    2 Kegg Pathways  (Kegg details for NADK):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways


    NADK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NADK
    Interactions:

        Search GeneGlobe Interaction Network for NADK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NADK (O955442, 3 ENSP000003416794) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3296408 I2D: score=3 STRING: ENSP00000309503
    LNX1Q8TBB13, ENSP000002639254I2D: score=4 STRING: ENSP00000263925
    GLRX3O760033, ENSP000003308364I2D: score=4 STRING: ENSP00000330836
    NUDT18Q6ZVK83, ENSP000003078524I2D: score=4 STRING: ENSP00000307852
    YWHAGP619813, ENSP000003063304I2D: score=2 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006741NADP biosynthetic process IEA--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0016310phosphorylation NAS11594753

    NADK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NADK

    5 HMDB Compounds for NADK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--

    6 Novoseek inferred chemical compound relationships for NADK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadp+ 77.2 2 15855156 (1), 16682646 (1)
    nad+ 69.1 6 15855156 (2), 17258457 (1), 16682646 (1)
    nadph 60.2 4 19430699 (2), 17855339 (1), 16244906 (1)
    nadh 53 11 15855156 (6), 19430699 (2)
    atp 26.3 3 19430699 (1), 15247403 (1), 16244906 (1)
    calcium 9.01 2 19639701 (1), 2154300 (1)



    NADK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NADK gene (4 alternative transcripts): 
    NM_001198993.1  NM_001198994.1  NM_001198995.1  NM_023018.4  

    Unigene Cluster for NADK:

    NAD kinase
    Hs.654792  [show with all ESTs]
    Unigene Representative Sequence: AF250320
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000341426(uc001aic.3) ENST00000341991(uc010nyv.2 uc001aid.4)
    ENST00000378625(uc009vkx.1 uc001aie.3) ENST00000498806 ENST00000469045
    ENST00000480499 ENST00000497747 ENST00000477235 ENST00000489538 ENST00000497615
    ENST00000497186 ENST00000400922 ENST00000492845 ENST00000492768 ENST00000460602
    ENST00000464373 ENST00000480542 ENST00000344463
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat NADK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NADK (see all 19):
    hsa-miR-30c hsa-miR-488 hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-29a* hsa-miR-3915 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidNADK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NADK
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): NADK (NM_023018)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NADK
      QuantiTect SYBR Green Assays in human, mouse, rat NADK
      QuantiFast Probe-based Assays in human, mouse, rat NADK

    Additional mRNA sequence: 

    AF070630.1 AF250320.1 AK023114.1 AK290161.1 AK291599.1 AK291728.1 AK296722.1 AY090771.1 
    BC001709.1 BC022063.2 BC024219.1 

    20 DOTS entries:

    DT.100812649  DT.419736  DT.100812651  DT.100812650  DT.100812658  DT.121399108  DT.97836870  DT.121399209 
    DT.95340380  DT.95340417  DT.92007756  DT.100649583  DT.100811850  DT.121399055  DT.91964138  DT.121399236 
    DT.91771510  DT.97859560  DT.100812646  DT.40193627 

    Selected AceView cDNA sequences (see all 454):

    CN481582 BF000608 CD673719 BU730035 AI742215 AA399105 CA427517 AI421182 
    AI811124 BI910876 BG232029 AA700036 AI184247 AI288504 CD368762 CB156624 
    Z39111 AI305152 AI816996 AI582479 BF591301 BU195659 AI871979 BM553002 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NADK (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15 ^
    SP1:                                            -     -                       -     -     -                       -     -     -                                 
    SP2:                                                  -                       -     -     -                       -     -     -                                 
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:  -                             -                                 
    SP2:  -                             -                                 
    SP3:  -                             -                                 
    SP4:  -                                                               
    SP5:  -                             -     -     -                     


    ECgene alternative splicing isoforms for NADK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NADK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCTGGGCA
    NADK Expression
    About this image


    NADK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Adrenal Gland (Endocrine System)
     
     Stomach (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    NADK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NADK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654792

    UniProtKB/Swiss-Prot: NADK_HUMAN, O95544
    Tissue specificity: Widely expressed but not detected in skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NADK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NADK gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nadk1 , 5 NAD kinase1, 5 86.08(n)1
    93.74(a)1
      4 (86.44 cM)5
    1921851  NM_001159637.11  NP_001153109.11 
     1555623785 
    chicken
    (Gallus gallus)
    Aves NADK1 NAD kinase 75.29(n)
    86.84(a)
      419403  NM_001030870.1  NP_001026041.1 
    lizard
    (Anolis carolinensis)
    Reptilia NADK6
    NAD kinase
    83(a)
    1 ↔ 1
    AAWZ02037388(10040-15642)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC059316.12   -- 78.66(n)    BC059316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nadka1 NAD kinase a 70.22(n)
    75.36(a)
      550242  NM_001017580.1  NP_001017580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331561 CG33156 61.5(n)
    62.79(a)
      36507  NM_176166.2  NP_788346.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTR1(YJR049C)4 ATP-NADH kinase; phosphorylates both NAD and NADH; more   --   10(528476-526884) 853508  NP_012583.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CB974760.12   -- 68.97(n)    CB974760.1 
    rice
    (Oryza sativa)
    Liliopsida Os.172822 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.11(n)    AK060751.1 


    ENSEMBL Gene Tree for NADK (if available)
    TreeFam Gene Tree for NADK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NADK gene
    1 SIMAP similar gene for NADK using alignment to 6 protein entries:     NADK_HUMAN (see all proteins):
    FLJ13052

    NADK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NADK (see all 765)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563104081,2
    C--1682374(+) GCCCCA/GGGAAT 4 -- int10--------
    rs1466326881,2
    C--1683327(+) GCTGCC/TGGTGC 4 -- ut310--------
    rs88411,2
    C--1683420(-) GCAACT/AGTAAT 4 -- ut315Minor allele frequency- A:0.36MN NA 560
    rs171628461,2
    C,F--1683565(+) CAGACG/AACTCC 4 -- ut31 ese34Minor allele frequency- A:0.43MN NA 190
    rs1458320401,2
    --1683599(+) AGTGTA/GTACGA 4 -- ut310--------
    rs1489526751,2
    C--1683655(+) AAAAGC/TATATA 4 -- ut310--------
    rs1437361331,2
    C--1683868(+) TTTCAA/GTGGCG 4 -- ut310--------
    rs10620901,2
    C--1683900(-) TAAAAC/TTTCTG 4 -- ut31 ese35Minor allele frequency- T:0.28NA WA EA 362
    rs1823152371,2
    --1684037(+) TTTGCA/GGAAAA 4 -- ut310--------
    rs22355341,2
    C--1684063(+) AATTGC/TGGCAG 4 -- ut31 ese34Minor allele frequency- T:0.13CSA WA EA 241

    HapMap Linkage Disequilibrium report for NADK (1682671 - 1711896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NADK (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749918CNV Deletion23290073
    nsv436343CNV Deletion17901297
    esv2749807CNV Deletion23290073
    nsv482957CNV Loss15286789
    nsv871954CNV Loss21882294
    nsv871560CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv34n71CNV Loss21882294
    dgv52n71CNV Loss21882294
    nsv870637CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NADK
    DNA2.0 Custom Variant and Variant Library Synthesis for NADK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611616    OMIM disorders: --

    4 diseases for NADK:    
    About MalaCards
    dental caries    tuberculosis    pneumonia    malaria


    NADK for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NADK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 43.3 6 15269221 (1), 19596199 (1), 17258457 (1)

    Genetic Association Database (GAD): NADK
    Human Genome Epidemiology (HuGE) Navigator: NADK (1 document)

    Export disorders for NADK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NADK gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with NADK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of human NAD kinase. (PubMed id 11594753)1, 2, 3, 9 Lerner F.... Ziegler M. (Biochem. Biophys. Res. Commun. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. NAD kinase levels control the NADPH concentration in human cells. (PubMed id 17855339)1, 9 Pollak N....Ziegler M. (J. Biol. Chem. 2007)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. NADPH regulates human NAD kinase, a NADPa8_-biosynthetic enzyme. (PubMed id 21526340)1 Ohashi K....Murata K. (Mol. Cell. Biochem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65220 HGNC: 29831 AceView: FLJ13052 Ensembl:ENSG00000008130 euGenes: HUgn65220
    ECgene: NADK Kegg: 65220 H-InvDB: NADK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NADK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NADK gene:
    Search GeneIP for patents involving NADK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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