NACC2 Gene
protein-coding GIFtS : 44
GCID: GC09 M138898
NACC family member 2, BEN and BTB (POZ) domain containing (Previous name: BTB (POZ) domain containing 14A ) (Previous symbol: BTBD14A )
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Aliasesfor NACC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases NACC Family Member 2, BEN And BTB (POZ) Domain Containing 1 2 BTB/POZ Domain-Containing Protein 14A2 3 BTBD14A1 2 3 MGC234271 BEND91 2 BTBD142 BTBD311 2 BEN Domain Containing 92 BTB (POZ) Domain Containing 14A1 2 Nucleus Accumbens-Associated Protein 22 NAC-22 3 NAC23
Export aliases for NACC2 gene to outside databases Previous GC identifers: GC09M138039 GC09M108365
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Summariesfor NACC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor NACC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_019501.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NACC2 gene promoter: STAT5B STAT1 STAT4 STAT6 STAT1beta STAT1alpha CREB deltaCREB STAT2 STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for NACC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NACC2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3 NACC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M138898: view genomic region
(about GC identifiers )
Start:
138,898,383 bp from pter
End:
138,987,131 bp from pter
Size:
88,749 bases
Orientation:
minus strand
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Proteinsfor NACC2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NACC2_HUMAN, Q96BF6 (See
protein sequence )Recommended Name: Nucleus accumbens-associated protein 2 Size : 587 amino acids; 62837 DaExplore the universe of human proteins at neXtProt for NACC2: NX_Q96BF6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96BF6 NACC2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_653254.1 ENSEMBL proteins: ENSP00000360818 ENSP00000277554 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
NACC2 for ontologies About GeneDecksing NACC2 Antibody Products: Assay Products for NACC2:
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Protein
Domains / Familiesfor NACC2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NACC2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96BF6 ProtoNet protein and cluster: Q96BF6
UniProtKB/Swiss-Prot: NACC2_HUMAN, Q96BF6 Similarity : Contains 1 BEN domainSimilarity : Contains 1 BTB (POZ) domain
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Functionfor NACC2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NACC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NACC2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NACC2 (NM_144653 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NACC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NACC2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC2
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
IDA -- GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
IDA -- GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
IDA -- GO:0004407 histone deacetylase activity
IDA -- GO:0005515 protein binding
IPI --
NACC2 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for NACC2 :
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Pathways & Interactionsfor NACC2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NACC2 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for NACC2 (Q96BF6 3 ENSP00000277554 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006366 transcription from RNA polymerase II promoter
IDA -- GO:0008284 positive regulation of cell proliferation
ISS -- GO:0008285 negative regulation of cell proliferation
IDA -- GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
IDA -- GO:0010608 posttranscriptional regulation of gene expression
IMP --
NACC2 for ontologies About GeneDecksing
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Drugs & Compoundsfor NACC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NACC2 Search CenterWatch for drugs/clinical trials and news about NACC2
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Transcriptsfor NACC2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NACC2 gene: NM_144653.4 Unigene Cluster for NACC2:
NACC family member 2, BEN and BTB (POZ) domain containing Hs.112895 [show with all ESTs ] Unigene Representative Sequence: NM_144653 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000371753 (uc004cgv.4 uc010nbh.3 ) ENST00000467669 ENST00000277554 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NACC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NACC2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NACC2 (NM_144653 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NACC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NACC2
Additional cDNA sequence: AK055078.1 AK056521.1 AK094914.1 AK308497.1 AK309247.1 AK311634.1 AL832276.1 BC015649.2 BC045702.1
6 DOTS entries : DT.312270 DT.308796
DT.75101753 DT.121403510 DT.40106727 DT.65287577 24/55 AceView cDNA sequences (see all 55 ):
BC015649 BQ929493 BM795567 CA425918 AI989498 BM714009 AI336998 NM_144653 BI823351 AW237064 AI741885 AI476455 BQ083066 AI380814 AI184528 AI917857 BM550374 BQ220455 BX331874 BM791117 BI517775 H81816 BU689592 AI806391 GeneLoc Exon Structure
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Expression for NACC2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NACC2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image NACC2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Brain Cerebral Cortex Brain Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See NACC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NACC2 SOURCE GeneReport for Unigene cluster: Hs.112895 SABiosciences Custom PCR Arrays for NACC2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NACC2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NACC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NACC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NACC2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC2
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Orthologsfor NACC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for NACC2 gene from 2/9 species (see all 9 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
NACC21
NACC family member 2, BEN and BTB (POZ) domain containing
81.02(n) 85.94(a)
 
417128 NM_001030681.1 NP_001025852.1
zebrafish (Danio rerio)
Actinopterygii
LOC5595201
nucleus accumbens-associated protein 2-like
67.23(n) 62.98(a)
 
559520 XM_682865.2 XP_687957.2
ENSEMBL Gene Tree for NACC2 (if available)TreeFam Gene Tree for NACC2 (if available)
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Paralogsfor NACC2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NACC2 gene ZBTB22 2 ZBTB34 2 NACC1 2 ZBTB6 2 ZBTB45 2 ZBTB9 2 ZBTB43 2 ZBTB26 2 ZBTB12 2 ZBTB37 2 ZBTB20 2 1 SIMAP similar gene for NACC2 using alignment to 1 protein entry: NACC2_HUMAN :NACC1
NACC2 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for NACC2 PGOHUM00000244444
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Genomic Variantsfor NACC2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NACC2 (138898383 - 138987131 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for NACC2 2 CNVs : 62960 4662 1 Indel : 100807
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NACC2
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Disorders
/ Diseasesfor NACC2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section NACC2 for disorders About MalaCards
NACC2 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: NACC2 (1 document)Export disorders for NACC2 gene to outside databases
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Publicationsfor NACC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NACC2 gene integrated from 9 sources : (articles sorted by number of sources associating them with NACC2) Utopia : connect your pdf to the dynamic world of online information
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004)
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External Searches for NACC2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NACC2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NACC2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NACC2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NACC2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NACC2 gene: Search GeneIP for patents involving NACC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NACC2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for NACC2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NACC2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NACC2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NACC2 OriGene 3'-UTR Clone for NACC2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NACC2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NACC2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NACC2 OriGene Custom Protein Services for NACC2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NACC2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NACC2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NACC2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NACC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NACC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NACC2
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NACC2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NACC2
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