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Aliases for NACC2 Gene

Aliases for NACC2 Gene

  • NACC Family Member 2 2 3
  • NACC Family Member 2, BEN And BTB (POZ) Domain Containing 2 3 5
  • Repressor With BTB Domain And BEN Domain 3 4
  • BTB/POZ Domain-Containing Protein 14A 3 4
  • BTB (POZ) Domain Containing 14A 2 3
  • BEN Domain Containing 9 2 3
  • BTBD14A 3 4
  • NAC-2 3 4
  • RBB 3 4
  • Transcription Repressor With A BTB Domain And A BEN Domain 3
  • BTBD14 3
  • BTBD31 3
  • BEND9 3
  • NAC2 4

External Ids for NACC2 Gene

Previous HGNC Symbols for NACC2 Gene

  • BTBD14A

Previous GeneCards Identifiers for NACC2 Gene

  • GC09M138039
  • GC09M138898
  • GC09M108365

Summaries for NACC2 Gene

GeneCards Summary for NACC2 Gene

NACC2 (NACC Family Member 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for NACC2 Gene

  • Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACC2 Gene

Genomics for NACC2 Gene

Regulatory Elements for NACC2 Gene

Enhancers for NACC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NACC2 on UCSC Golden Path with GeneCards custom track

Promoters for NACC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NACC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NACC2 Gene

136,006,537 bp from pter
136,095,285 bp from pter
88,749 bases
Minus strand

Genomic View for NACC2 Gene

Genes around NACC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACC2 Gene

Proteins for NACC2 Gene

  • Protein details for NACC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleus accumbens-associated protein 2
    Protein Accession:

    Protein attributes for NACC2 Gene

    587 amino acids
    Molecular mass:
    62837 Da
    Quaternary structure:
    • Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3.

neXtProt entry for NACC2 Gene

Proteomics data for NACC2 Gene at MOPED

Post-translational modifications for NACC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACC2 Gene

Domains & Families for NACC2 Gene

Gene Families for NACC2 Gene

Protein Domains for NACC2 Gene

Suggested Antigen Peptide Sequences for NACC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BEN domain.
  • Contains 1 BEN domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with NACC2: view

Function for NACC2 Gene

Molecular function for NACC2 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

Gene Ontology (GO) - Molecular Function for NACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 22926524
genes like me logo Genes that share ontologies with NACC2: view
genes like me logo Genes that share phenotypes with NACC2: view

Animal Models for NACC2 Gene

MGI Knock Outs for NACC2:

Animal Model Products

miRNA for NACC2 Gene

miRTarBase miRNAs that target NACC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NACC2 Gene

Localization for NACC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACC2 Gene

Nucleus. Note=Predominantly associated with chromatin.

Subcellular locations from

Jensen Localization Image for NACC2 Gene COMPARTMENTS Subcellular localization image for NACC2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NACC2 Gene

Pathways & Interactions for NACC2 Gene

SuperPathways for NACC2 Gene

No Data Available

Interacting Proteins for NACC2 Gene

Gene Ontology (GO) - Biological Process for NACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010608 posttranscriptional regulation of gene expression IMP 22926524
GO:0034629 cellular protein complex localization IDA 22926524
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:0051260 protein homooligomerization ISS --
GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter IDA 22926524
genes like me logo Genes that share ontologies with NACC2: view

No data available for Pathways by source and SIGNOR curated interactions for NACC2 Gene

Drugs & Compounds for NACC2 Gene

No Compound Related Data Available

Transcripts for NACC2 Gene

Unigene Clusters for NACC2 Gene

NACC family member 2, BEN and BTB (POZ) domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACC2 Gene

No ASD Table

Relevant External Links for NACC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NACC2 Gene

mRNA expression in normal human tissues for NACC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NACC2 Gene

This gene is overexpressed in CD8 Tcells (26.9), Adipocyte (25.7), and Gallbladder (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NACC2 Gene

SOURCE GeneReport for Unigene cluster for NACC2 Gene Hs.112895

genes like me logo Genes that share expression patterns with NACC2: view

Protein tissue co-expression partners for NACC2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NACC2 Gene

Orthologs for NACC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NACC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NACC2 35
  • 91.67 (n)
  • 94.35 (a)
NACC2 36
  • 94 (a)
(Canis familiaris)
Mammalia NACC2 35
  • 91 (n)
  • 93.5 (a)
NACC2 36
  • 95 (a)
(Mus musculus)
Mammalia Nacc2 35
  • 86.36 (n)
  • 93.32 (a)
Nacc2 16
Nacc2 36
  • 93 (a)
(Pan troglodytes)
Mammalia NACC2 35
  • 99.32 (n)
  • 99.32 (a)
NACC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nacc2 35
  • 86.34 (n)
  • 92.45 (a)
(Monodelphis domestica)
Mammalia NACC2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia NACC2 36
  • 87 (a)
(Gallus gallus)
Aves NACC2 35
  • 80.79 (n)
  • 85.42 (a)
NACC2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nacc2 35
  • 74.99 (n)
  • 79.93 (a)
(Danio rerio)
Actinopterygii LOC559520 35
  • 67.59 (n)
  • 63.54 (a)
NACC2 36
  • 60 (a)
Species with no ortholog for NACC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NACC2 Gene

Gene Tree for NACC2 (if available)
Gene Tree for NACC2 (if available)

Paralogs for NACC2 Gene

(1) SIMAP similar genes for NACC2 Gene using alignment to 1 proteins: Pseudogenes for NACC2 Gene

genes like me logo Genes that share paralogs with NACC2: view

Variants for NACC2 Gene

Sequence variations from dbSNP and Humsavar for NACC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs871093 -- 136,063,057(+) CTTCT(A/G)ATTTT intron-variant
rs871094 -- 136,062,849(+) GAGGC(C/T)GAGGC intron-variant
rs871095 -- 136,063,400(-) TGTAC(A/G)TGACC intron-variant
rs884558 -- 136,047,756(+) TGCTG(A/G)CTCCC intron-variant
rs884559 -- 136,047,816(+) CCAGG(C/T)GATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NACC2 Gene

Variant ID Type Subtype PubMed ID
nsv831757 CNV Loss 17160897
dgv8372n71 CNV Loss 21882294
nsv825173 CNV Gain 20364138
dgv8373n71 CNV Loss 21882294
dgv8374n71 CNV Loss 21882294
nsv894285 CNV Gain 21882294
dgv8376n71 CNV Loss 21882294
dgv8377n71 CNV Loss 21882294
nsv894294 CNV Loss 21882294
nsv894295 CNV Loss 21882294
nsv894296 CNV Loss 21882294
nsv6761 CNV Insertion 18451855
nsv525592 CNV Loss 19592680
nsv894297 CNV Loss 21882294
dgv8378n71 CNV Loss 21882294
esv2739318 CNV Deletion 23290073
esv2739319 CNV Deletion 23290073
nsv525309 CNV Loss 19592680
dgv8379n71 CNV Loss 21882294
nsv894301 CNV Loss 21882294
esv2739320 CNV Deletion 23290073
nsv415932 CNV Insertion 16902084
nsv415943 CNV Insertion 16902084
nsv469916 CNV Loss 18288195
nsv509332 CNV Insertion 20534489
dgv1387e199 CNV Deletion 23128226
esv6079 CNV Loss 19470904
esv2676603 CNV Deletion 23128226
dgv8380n71 CNV Loss 21882294
dgv8381n71 CNV Loss 21882294
dgv8382n71 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
esv2521942 CNV Insertion 19546169
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
esv1257856 CNV Insertion 17803354
nsv894316 CNV Loss 21882294
nsv466670 CNV Gain 19166990

Variation tolerance for NACC2 Gene

Gene Damage Index Score: 3.25; 52.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NACC2 Gene

Disorders for NACC2 Gene

Relevant External Links for NACC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NACC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NACC2 Gene

Publications for NACC2 Gene

  1. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C. … Shang Y. (Oncogene 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for NACC2 Gene

Sources for NACC2 Gene