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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NACC2 Gene

protein-coding   GIFtS: 44
GCID: GC09M138898

NACC family member 2, BEN and BTB (POZ) domain containing

(Previous name: BTB (POZ) domain containing 14A )
(Previous symbol: BTBD14A)
  Search for NACC2
in our new
 Human Malady Compendium 
Biological research products
for NACC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NACC Family Member 2, BEN And BTB (POZ) Domain Containing1 2     BTB/POZ Domain-Containing Protein 14A2 3
BTBD14A1 2 3     MGC234271
BEND91 2     BTBD142
BTBD311 2     BEN Domain Containing 92
BTB (POZ) Domain Containing 14A1 2     Nucleus Accumbens-Associated Protein 22
NAC-22 3     NAC23

External Ids:    HGNC: 238461   Entrez Gene: 1381512   Ensembl: ENSG000001484117   UniProtKB: Q96BF63   

Export aliases for NACC2 gene to outside databases

Previous GC identifers: GC09M138039 GC09M108365


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_019501.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NACC2 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT1alpha   CREB   deltaCREB   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NACC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NACC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

NACC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACC2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M138898:  view genomic region     (about GC identifiers)

Start:
138,898,383 bp from pter      End:
138,987,131 bp from pter
Size:
88,749 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NACC2_HUMAN, Q96BF6 (See protein sequence)
Recommended Name: Nucleus accumbens-associated protein 2  
Size: 587 amino acids; 62837 Da

Explore the universe of human proteins at neXtProt for NACC2: NX_Q96BF6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BF6

  • NACC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_653254.1  
    ENSEMBL proteins: 
     ENSP00000360818   ENSP00000277554  

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    Uscn Proteins for NACC2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus ISS--
    GO:0016581colocalizes with NuRD complex IDA--
    GO:0016604nuclear body ISS--


    NACC2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NACC2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ
     IPR018379 BEN_domain
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q96BF6

    ProtoNet protein and cluster: Q96BF6

    UniProtKB/Swiss-Prot: NACC2_HUMAN, Q96BF6
    Similarity: Contains 1 BEN domain
    Similarity: Contains 1 BTB (POZ) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-194* hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3921 hsa-miR-519a hsa-miR-1273d hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidNACC2 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: NACC2
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA--
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IDA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0004407histone deacetylase activity IDA--
    GO:0005515protein binding IPI--


    NACC2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NACC2:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NACC2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for NACC2 (Q96BF63 ENSP000002775544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NACC1Q96RE73I2D: score=2 
    EPS8ENSP000002811724STRING: ENSP00000281172
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter IDA--
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0008285negative regulation of cell proliferation IDA--
    GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage IDA--
    GO:0010608posttranscriptional regulation of gene expression IMP--


    NACC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NACC2
    Search CenterWatch for drugs/clinical trials and news about NACC2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NACC2 gene: 
    NM_144653.4  

    Unigene Cluster for NACC2:

    NACC family member 2, BEN and BTB (POZ) domain containing
    Hs.112895  [show with all ESTs]
    Unigene Representative Sequence: NM_144653
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371753(uc004cgv.4 uc010nbh.3) ENST00000467669 ENST00000277554


    miRNA
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    hsa-miR-194* hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3921 hsa-miR-519a hsa-miR-1273d hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidNACC2 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NACC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NACC2

    Additional cDNA sequence: 

    AK055078.1 AK056521.1 AK094914.1 AK308497.1 AK309247.1 AK311634.1 AL832276.1 BC015649.2 
    BC045702.1 

    6 DOTS entries:

    DT.312270  DT.308796  DT.75101753  DT.121403510  DT.40106727  DT.65287577 

    24/55 AceView cDNA sequences (see all 55):

    BC015649 BQ929493 BM795567 CA425918 AI989498 BM714009 AI336998 NM_144653 
    BI823351 AW237064 AI741885 AI476455 BQ083066 AI380814 AI184528 AI917857 
    BM550374 BQ220455 BX331874 BM791117 BI517775 H81816 BU689592 AI806391 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NACC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NACC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NACC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NACC2

    SOURCE GeneReport for Unigene cluster: Hs.112895
        SABiosciences Custom PCR Arrays for NACC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NACC2 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NACC21 NACC family member 2, BEN and BTB (POZ) domain containing 81.02(n)
    85.94(a)
      417128  NM_001030681.1  NP_001025852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5595201 nucleus accumbens-associated protein 2-like 67.23(n)
    62.98(a)
      559520  XM_682865.2  XP_687957.2 


    ENSEMBL Gene Tree for NACC2 (if available)
    TreeFam Gene Tree for NACC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NACC2 gene
    ZBTB222  ZBTB342  NACC12  ZBTB62  ZBTB452  ZBTB92  ZBTB432  ZBTB262  
    ZBTB122  ZBTB372  ZBTB202  
    1 SIMAP similar gene for NACC2 using alignment to 1 protein entry:     NACC2_HUMAN:
    NACC1

    NACC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NACC2
    PGOHUM00000244444


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1545 NCBI SNPs in NACC2 are shown (see all 1545    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78748681,2
    C,A,--138898003(+) GGTGAG/AGCAGA 1 -- ds50014Minor allele frequency- A:0.05CSA WA NA EA 360
    rs78758931,2
    C,F,A,H,--138898063(+) GAGACC/TCCCCG 1 -- ds50018Minor allele frequency- T:0.03NS EA WA NA 752
    rs1151839721,2
    F,--138898087(+) GCCTGC/TGGGTC 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs107768661,2
    C,F,A,H,--138898172(+) CACTGA/GGGAGA 1 -- ds500128Minor allele frequency- G:0.49NS EA NA WA CSA 2777
    rs111032621,2
    C,F,H,--138898254(+) GGGACG/ACCGCT 1 -- ds500117Minor allele frequency- A:0.12NS EA NA WA 2158
    rs1468415011,2
    --138898265(+) AACAGG/TGACGG 1 -- ds50010--------
    rs795632301,2
    --138898317(+) CTTCAA/GTAGCC 1 -- ds50010--------
    rs1444070981,2
    --138898415(+) GTAAAC/TGTGAA 1 -- ut310--------
    rs1452274481,2
    --138898514(+) CCCTCA/GGTTTC 1 -- ut310--------
    rs1491763111,2
    --138898539(+) AATGTG/TTCAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NACC2 (138898383 - 138987131 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NACC2
         2 CNVs: 62960 4662
         1 Indel: 100807

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NACC2 for disorders           About MalaCards

    NACC2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: NACC2 (1 document)

    Export disorders for NACC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NACC2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NACC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 138151 HGNC: 23846 AceView: BTBD14A Ensembl:ENSG00000148411 euGenes: HUgn138151
    ECgene: NACC2 H-InvDB: NACC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NACC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NACC2 gene:
    Search GeneIP for patents involving NACC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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