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Aliases for NACC2 Gene

Aliases for NACC2 Gene

  • NACC Family Member 2, BEN And BTB (POZ) Domain Containing 2 3
  • Repressor With BTB Domain And BEN Domain 3 4
  • BTB/POZ Domain-Containing Protein 14A 3 4
  • BTB (POZ) Domain Containing 14A 2 3
  • BEN Domain Containing 9 2 3
  • BTBD14A 3 4
  • NAC-2 3 4
  • RBB 3 4
  • Transcription Repressor With A BTB Domain And A BEN Domain 3
  • Nucleus Accumbens-Associated Protein 2 3
  • BTBD14 3
  • BTBD31 3
  • BEND9 3
  • NAC2 4

External Ids for NACC2 Gene

Previous HGNC Symbols for NACC2 Gene

  • BTBD14A

Previous GeneCards Identifiers for NACC2 Gene

  • GC09M138039
  • GC09M138898
  • GC09M108365

Summaries for NACC2 Gene

GeneCards Summary for NACC2 Gene

NACC2 (NACC Family Member 2, BEN And BTB (POZ) Domain Containing) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for NACC2 Gene

  • Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACC2 Gene

Genomics for NACC2 Gene

Regulatory Elements for NACC2 Gene

Genomic Location for NACC2 Gene

Start:
136,006,537 bp from pter
End:
136,095,285 bp from pter
Size:
88,749 bases
Orientation:
Minus strand

Genomic View for NACC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NACC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACC2 Gene

Proteins for NACC2 Gene

  • Protein details for NACC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BF6-NACC2_HUMAN
    Recommended name:
    Nucleus accumbens-associated protein 2
    Protein Accession:
    Q96BF6
    Secondary Accessions:

    Protein attributes for NACC2 Gene

    Size:
    587 amino acids
    Molecular mass:
    62837 Da
    Quaternary structure:
    • Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3.

neXtProt entry for NACC2 Gene

Proteomics data for NACC2 Gene at MOPED

Post-translational modifications for NACC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACC2 Gene

Domains for NACC2 Gene

Gene Families for NACC2 Gene

HGNC:
  • BEND :BEN domain containing
  • BTBD :BTB/POZ domain containing

Protein Domains for NACC2 Gene

Suggested Antigen Peptide Sequences for NACC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BF6

UniProtKB/Swiss-Prot:

NACC2_HUMAN :
  • Q96BF6
Domain:
  • Contains 1 BEN domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with NACC2: view

Function for NACC2 Gene

Molecular function for NACC2 Gene

UniProtKB/Swiss-Prot Function: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

Gene Ontology (GO) - Molecular Function for NACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 22926524
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity IDA 22926524
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 22926524
GO:0004407 histone deacetylase activity IDA 22926524
GO:0005515 protein binding IPI 22926524
genes like me logo Genes that share ontologies with NACC2: view

Phenotypes for NACC2 Gene

GenomeRNAi human phenotypes for NACC2:
genes like me logo Genes that share phenotypes with NACC2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NACC2 Gene

Localization for NACC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACC2 Gene

Nucleus. Note=Predominantly associated with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NACC2 Gene COMPARTMENTS Subcellular localization image for NACC2 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 22926524
GO:0005634 nucleus ISS --
GO:0016581 colocalizes_with NuRD complex IDA 22926524
GO:0016604 nuclear body ISS --
genes like me logo Genes that share ontologies with NACC2: view

Pathways for NACC2 Gene

SuperPathways for NACC2 Gene

No Data Available

Interacting Proteins for NACC2 Gene

Gene Ontology (GO) - Biological Process for NACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IDA 22926524
GO:0008284 positive regulation of cell proliferation ISS --
GO:0008285 negative regulation of cell proliferation IDA 22926524
GO:0010608 posttranscriptional regulation of gene expression IMP 22926524
GO:0016575 histone deacetylation IDA 22926524
genes like me logo Genes that share ontologies with NACC2: view

No data available for Pathways by source for NACC2 Gene

Transcripts for NACC2 Gene

Unigene Clusters for NACC2 Gene

NACC family member 2, BEN and BTB (POZ) domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACC2 Gene

No ASD Table

Relevant External Links for NACC2 Gene

GeneLoc Exon Structure for
NACC2
ECgene alternative splicing isoforms for
NACC2

Expression for NACC2 Gene

mRNA expression in normal human tissues for NACC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NACC2 Gene

SOURCE GeneReport for Unigene cluster for NACC2 Gene Hs.112895

genes like me logo Genes that share expressions with NACC2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NACC2 Gene

Orthologs for NACC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NACC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACC2 35
  • 99.32 (n)
  • 99.32 (a)
NACC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NACC2 35
  • 91.67 (n)
  • 94.35 (a)
NACC2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NACC2 35
  • 91 (n)
  • 93.5 (a)
NACC2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nacc2 35
  • 86.36 (n)
  • 93.32 (a)
Nacc2 16
Nacc2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NACC2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NACC2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nacc2 35
  • 86.34 (n)
  • 92.45 (a)
chicken
(Gallus gallus)
Aves NACC2 35
  • 80.79 (n)
  • 85.42 (a)
NACC2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nacc2 35
  • 74.99 (n)
  • 79.93 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559520 35
  • 67.59 (n)
  • 63.54 (a)
NACC2 36
  • 60 (a)
OneToOne
Species with no ortholog for NACC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NACC2 Gene

ENSEMBL:
Gene Tree for NACC2 (if available)
TreeFam:
Gene Tree for NACC2 (if available)

Paralogs for NACC2 Gene

Selected SIMAP similar genes for NACC2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NACC2 Gene

genes like me logo Genes that share paralogs with NACC2: view

Variants for NACC2 Gene

Sequence variations from dbSNP and Humsavar for NACC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs9626 -- 136,011,825(-) CCGCC(C/T)GCCGC synonymous-codon, reference
rs9753 -- 136,011,789(-) TACGC(C/T)GAGCG reference, synonymous-codon
rs871093 -- 136,063,057(+) CTTCT(A/G)ATTTT intron-variant
rs871094 -- 136,062,849(+) GAGGC(C/T)GAGGC intron-variant
rs871095 -- 136,063,400(-) TGTAC(A/G)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NACC2 Gene

Variant ID Type Subtype PubMed ID
nsv831757 CNV Loss 17160897
dgv8372n71 CNV Loss 21882294
nsv825173 CNV Gain 20364138
dgv8373n71 CNV Loss 21882294
dgv8374n71 CNV Loss 21882294
nsv894285 CNV Gain 21882294
dgv8376n71 CNV Loss 21882294
dgv8377n71 CNV Loss 21882294
nsv894294 CNV Loss 21882294
nsv894295 CNV Loss 21882294
nsv894296 CNV Loss 21882294
nsv6761 CNV Insertion 18451855
nsv525592 CNV Loss 19592680
nsv894297 CNV Loss 21882294
dgv8378n71 CNV Loss 21882294
esv2739318 CNV Deletion 23290073
esv2739319 CNV Deletion 23290073
nsv525309 CNV Loss 19592680
dgv8379n71 CNV Loss 21882294
nsv894301 CNV Loss 21882294
esv2739320 CNV Deletion 23290073
nsv415932 CNV Insertion 16902084
nsv415943 CNV Insertion 16902084
nsv469916 CNV Loss 18288195
nsv509332 CNV Insertion 20534489
dgv1387e199 CNV Deletion 23128226
esv6079 CNV Loss 19470904
esv2676603 CNV Deletion 23128226
dgv8380n71 CNV Loss 21882294
dgv8381n71 CNV Loss 21882294
dgv8382n71 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
esv2521942 CNV Insertion 19546169
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
esv1257856 CNV Insertion 17803354
nsv894316 CNV Loss 21882294
nsv466670 CNV Gain 19166990

Relevant External Links for NACC2 Gene

HapMap Linkage Disequilibrium report
NACC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NACC2 Gene

Disorders for NACC2 Gene

Relevant External Links for NACC2

Genetic Association Database (GAD)
NACC2
Human Genome Epidemiology (HuGE) Navigator
NACC2
genes like me logo Genes that share disorders with NACC2: view

No data available for UniProtKB/Swiss-Prot for NACC2 Gene

Publications for NACC2 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C. … Shang Y. (Oncogene 2013) 3 4

Products for NACC2 Gene

Sources for NACC2 Gene

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