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Aliases for NACC1 Gene

Aliases for NACC1 Gene

  • Nucleus Accumbens Associated 1 2 3 2
  • Nucleus Accumbens Associated 1, BEN And BTB (POZ) Domain Containing 2 3 5
  • BTB/POZ Domain-Containing Protein 14B 3 4
  • BEN Domain Containing 8 2 3
  • BTBD14B 3 4
  • NAC-1 3 4
  • NAC1 3 4
  • BTB (POZ) Domain Containing 14B 2
  • Transcriptional Repressor NAC1 3
  • BTBD30 3
  • BEND8 3

External Ids for NACC1 Gene

Previous HGNC Symbols for NACC1 Gene

  • BTBD14B

Previous GeneCards Identifiers for NACC1 Gene

  • GC19P013091
  • GC19P013229
  • GC19P012818

Summaries for NACC1 Gene

Entrez Gene Summary for NACC1 Gene

  • This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]

GeneCards Summary for NACC1 Gene

NACC1 (Nucleus Accumbens Associated 1) is a Protein Coding gene. Diseases associated with NACC1 include Argininemia. Among its related pathways are Neuroscience. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for NACC1 Gene

  • Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

Gene Wiki entry for NACC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACC1 Gene

Genomics for NACC1 Gene

Regulatory Elements for NACC1 Gene

Enhancers for NACC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NACC1 on UCSC Golden Path with GeneCards custom track

Promoters for NACC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NACC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NACC1 Gene

Chromosome:
19
Start:
13,116,847 bp from pter
End:
13,141,147 bp from pter
Size:
24,301 bases
Orientation:
Plus strand

Genomic View for NACC1 Gene

Genes around NACC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACC1 Gene

Proteins for NACC1 Gene

  • Protein details for NACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RE7-NACC1_HUMAN
    Recommended name:
    Nucleus accumbens-associated protein 1
    Protein Accession:
    Q96RE7

    Protein attributes for NACC1 Gene

    Size:
    527 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.

    Three dimensional structures from OCA and Proteopedia for NACC1 Gene

neXtProt entry for NACC1 Gene

Proteomics data for NACC1 Gene at MOPED

Post-translational modifications for NACC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NACC1 (NAC1)
  • Abcam antibodies for Nac1

No data available for DME Specific Peptides for NACC1 Gene

Domains & Families for NACC1 Gene

Gene Families for NACC1 Gene

Protein Domains for NACC1 Gene

Suggested Antigen Peptide Sequences for NACC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RE7

UniProtKB/Swiss-Prot:

NACC1_HUMAN :
  • Contains 1 BEN domain.
Domain:
  • Contains 1 BEN domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with NACC1: view

Function for NACC1 Gene

Molecular function for NACC1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
genes like me logo Genes that share phenotypes with NACC1: view

Animal Models for NACC1 Gene

MGI Knock Outs for NACC1:

Animal Model Products

miRNA for NACC1 Gene

miRTarBase miRNAs that target NACC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NACC1 Gene

Localization for NACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACC1 Gene

Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NACC1 Gene COMPARTMENTS Subcellular localization image for NACC1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016604 nuclear body IDA 17130457
genes like me logo Genes that share ontologies with NACC1: view

Pathways & Interactions for NACC1 Gene

SuperPathways for NACC1 Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with NACC1: view

Pathways by source for NACC1 Gene

1 Cell Signaling Technology pathway for NACC1 Gene

Gene Ontology (GO) - Biological Process for NACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 17130457
GO:0045892 negative regulation of transcription, DNA-templated IMP 17804717
GO:0051260 protein homooligomerization IDA 17130457
genes like me logo Genes that share ontologies with NACC1: view

No data available for SIGNOR curated interactions for NACC1 Gene

Drugs & Compounds for NACC1 Gene

No Compound Related Data Available

Transcripts for NACC1 Gene

Unigene Clusters for NACC1 Gene

Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACC1 Gene

No ASD Table

Relevant External Links for NACC1 Gene

GeneLoc Exon Structure for
NACC1
ECgene alternative splicing isoforms for
NACC1

Expression for NACC1 Gene

mRNA expression in normal human tissues for NACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NACC1 Gene

This gene is overexpressed in CD8 Tcells (20.9), CD4 Tcells (10.2), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NACC1 Gene



SOURCE GeneReport for Unigene cluster for NACC1 Gene Hs.531614

mRNA Expression by UniProt/SwissProt for NACC1 Gene

Q96RE7-NACC1_HUMAN
Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
genes like me logo Genes that share expression patterns with NACC1: view

Protein tissue co-expression partners for NACC1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for NACC1 Gene

Orthologs for NACC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NACC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NACC1 35
  • 87.98 (n)
  • 90.32 (a)
NACC1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NACC1 35
  • 87.47 (n)
  • 90.63 (a)
NACC1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nacc1 35
  • 84.21 (n)
  • 89.63 (a)
Nacc1 16
Nacc1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NACC1 35
  • 99.56 (n)
  • 100 (a)
NACC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nacc1 35
  • 84.41 (n)
  • 89.43 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NACC1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NACC1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nacc1 35
  • 77.57 (n)
  • 81.67 (a)
Str.10168 35
zebrafish
(Danio rerio)
Actinopterygii LOC572093 35
  • 67.71 (n)
  • 75.25 (a)
NACC1 36
  • 65 (a)
OneToOne
Species with no ortholog for NACC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NACC1 Gene

ENSEMBL:
Gene Tree for NACC1 (if available)
TreeFam:
Gene Tree for NACC1 (if available)

Paralogs for NACC1 Gene

genes like me logo Genes that share paralogs with NACC1: view

Variants for NACC1 Gene

Sequence variations from dbSNP and Humsavar for NACC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256436 -- 13,123,308(+) TTATG(A/G)TTGGA intron-variant
rs7259253 -- 13,126,688(+) TGGCA(A/G)CTGTC intron-variant
rs12981904 -- 13,138,042(+) CTCGT(C/T)TCCCC intron-variant
rs12982296 -- 13,131,526(+) TTTCT(C/T)CTGCC intron-variant
rs8103456 -- 13,127,853(+) aaaag(C/G)aaaaG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NACC1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911086 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3737n71 CNV Loss 21882294

Variation tolerance for NACC1 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NACC1 Gene

Human Gene Mutation Database (HGMD)
NACC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NACC1 Gene

Disorders for NACC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NACC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
argininemia
  • hyperargininemia
- elite association - COSMIC cancer census association via MalaCards
Search NACC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NACC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NACC1
genes like me logo Genes that share disorders with NACC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NACC1 Gene

Publications for NACC1 Gene

  1. Structure of the human Nac1 POZ domain. (PMID: 19407373) Stead M.A. … Wright S.C. (Acta Crystallogr. F 2009) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification. (PMID: 25891951) Tatemichi Y. … Maesawa C. (Cancer Sci. 2015) 3

Products for NACC1 Gene

Sources for NACC1 Gene

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