Aliases for NACC1 Gene
External Ids for NACC1 Gene
Previous HGNC Symbols for NACC1 Gene
Previous GeneCards Identifiers for NACC1 Gene
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
GeneCards Summary for NACC1 Gene
NACC1 (Nucleus Accumbens Associated 1) is a Protein Coding gene. Diseases associated with NACC1 include Argininemia and Ovarian Cancer. Among its related pathways are Neuroscience. An important paralog of this gene is NACC2.
UniProtKB/Swiss-Prot for NACC1 Gene
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.