Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NACC1 Gene

protein-coding   GIFtS: 51
GCID: GC19P013229

nucleus accumbens associated 1, BEN and BTB (POZ) domain...

(Previous name: BTB (POZ) domain containing 14B )
(Previous symbol: BTBD14B)
 Explore 11 diseases affiliated with
NACC1 via our new
 Human Malady Compendium 
Biological research products
for NACC1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nucleus Accumbens Associated 1, BEN And BTB (POZ) Domain Containing1 2     BTB/POZ Domain-Containing Protein 14B2 3
BTBD14B1 2 3     BTB (POZ) Domain Containing 14B1
NAC-11 2 3     BEN Domain Containing 82
NAC11 2 3     Nucleus Accumbens-Associated Protein 12
BEND81 2     Transcriptional Repressor NAC12
BTBD301 2     

External Ids:    HGNC: 209671   Entrez Gene: 1129392   Ensembl: ENSG000001608777   OMIM: 6106725   UniProtKB: Q96RE73   

Export aliases for NACC1 gene to outside databases

Previous GC identifers: GC19P013091 GC19P012818


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NACC1:
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes
including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor
that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses
transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the
progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9.
(provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7
Function: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal
cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and
survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required
for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines

Gene Wiki entry for NACC1 (BTBD14B)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NACC1 gene promoter:
         AREB6   USF1   Spz1   AML1a   USF-1   c-Myb   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNACC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NACC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NACC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

NACC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013229:  view genomic region     (about GC identifiers)

Start:
13,228,917 bp from pter      End:
13,251,959 bp from pter
Size:
23,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7 (See protein sequence)
Recommended Name: Nucleus accumbens-associated protein 1  
Size: 527 amino acids; 57258 Da
Subunit: Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with
CUL3, PSMD7 AND RCOR1
Subcellular location: Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation (By
similarity)
1 PDB 3D structure from and Proteopedia for NACC1:
3GA1 (3D)    

Explore the universe of human proteins at neXtProt for NACC1: NX_Q96RE7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96RE7

  • NACC1 Protein expression data from MOPED and PaxDb:    About this image 
    NACC1 Protein Expression
    REFSEQ proteins: NP_443108.1  
    ENSEMBL proteins: 
     ENSP00000467120   ENSP00000292431   ENSP00000466017  

    Human Recombinant Protein Products for NACC1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NACC1 
    GenScript Custom Purified and Recombinant Proteins Services for NACC1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NACC1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016604nuclear body IDA17130457
    GO:0043231intracellular membrane-bounded organelle IDA--

    NACC1 for ontologies           About GeneDecksing



    NACC1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NACC1  (NAC1)
    OriGene Antibodies (see all 2): NACC1
    OriGene Custom Antibody Services for NACC1 
    GenScript Custom Superior Antibodies Services for NACC1
    Novus Biologicals NACC1 Antibodies
    Abcam antibodies for NACC1 
    Uscn Antibodies for NACC1
    ThermoFisher Antibody for NACC1

    Assay Products for NACC1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NACC1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NACC1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NACC1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ
     IPR018379 BEN_domain
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q96RE7

    ProtoNet protein and cluster: Q96RE7

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7
    Similarity: Contains 1 BEN domain
    Similarity: Contains 1 BTB (POZ) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NACC1_HUMAN, Q96RE7
    Function: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal
    cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and
    survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required
    for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NACC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NACC1:
     Decreased Hepatitis C virus re  Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nacc1):
     behavior/neurological  homeostasis/metabolism 

    NACC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NACC1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NACC1:
    hsa-mir-218 (MIRT004542)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NACC1
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate NACC1 (see all 61):
    hsa-miR-1914* hsa-miR-199a-3p hsa-let-7a-2* hsa-miR-218 hsa-miR-1244 hsa-miR-124 hsa-miR-9 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNACC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NACC1 (see all 4)
    OriGene shRNA RFP: NACC1
    OriGene siRNA: NACC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NACC1
    Sirion Biotech Custom design and validation of potent shRNA sequences against NACC1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NACC1
    Sirion Biotech Customized adenovirus for overexpression of NACC1 
    Sirion Biotech Customized adenovirus for potent knockdown of NACC1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NACC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NACC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NACC1 (NM_052876)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NACC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NACC1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NACC1
    Search LifeMap BioReagents cell lines for NACC1
    Sirion Biotech Customized stable knockdown cell line services for NACC1 
    Sirion Biotech Customized inducible knockdown cell line services for NACC1
    Sirion Biotech Customized stable overexpressing cell line services for NACC1
    Sirion Biotech Customized inducible overexpressing cell line services for NACC1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NACC1
        Neuroscience



    NACC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NACC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/758 Interacting proteins for NACC1 (Q96RE72, 3 ENSP000002924314) via UniProtKB, MINT, STRING, and/or I2D (see all 758)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIF1Q5UIP02, 3MINT-7945693 MINT-7947479 I2D: score=2 
    SMARCC1Q929222, 3MINT-7945693 MINT-7947479 I2D: score=2 
    WDR18Q9BV382, 3MINT-7945693 MINT-7947479 I2D: score=2 
    GATAD2BQ8WXI92, 3MINT-7945693 I2D: score=2 
    MYBBP1AQ9BQG02, 3MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006917induction of apoptosis IEA--
    GO:0008284positive regulation of cell proliferation IMP17804717
    GO:0045892negative regulation of transcription, DNA-dependent IMP17804717
    GO:0051260protein homooligomerization IDA17130457

    NACC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NACC1
    Search CenterWatch for drugs/clinical trials and news about NACC1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NACC1 gene: 
    NM_052876.3  

    Unigene Cluster for NACC1:

    Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
    Hs.531614  [show with all ESTs]
    Unigene Representative Sequence: NM_052876
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586171 ENST00000292431(uc002mwm.3) ENST00000585663

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NACC1
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate NACC1 (see all 61):
    hsa-miR-1914* hsa-miR-199a-3p hsa-let-7a-2* hsa-miR-218 hsa-miR-1244 hsa-miR-124 hsa-miR-9 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNACC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NACC1 (see all 4)
    OriGene shRNA RFP: NACC1
    OriGene siRNA: NACC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NACC1
    Sirion Biotech Custom design and validation of potent shRNA sequences against NACC1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NACC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NACC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NACC1 (NM_052876)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NACC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NACC1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NACC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NACC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NACC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NACC1

    Additional cDNA sequence: 

    AF395817.1 AK094702.1 AK123056.1 AK226064.1 BC055396.1 

    9 DOTS entries:

    DT.438889  DT.95094570  DT.91740869  DT.100779374  DT.102832319  DT.121412308  DT.91662413  DT.121157120 
    DT.95364391 

    24/146 AceView cDNA sequences (see all 146):

    BM458054 AI253160 BU507965 AF395817 CR623895 AI659103 AA314443 AA031357 
    BX956897 BE551636 BQ219585 BU684970 BU507699 CA946320 CA422474 NM_052876 
    AK094702 BU169499 AI633928 AI948654 AI524488 AK123056 BE536053 BX376936 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NACC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAATATCAG
    NACC1 Expression
    About this image
    See NACC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NACC1

    SOURCE GeneReport for Unigene cluster: Hs.531614

    UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7
    Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels
    positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary
    ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in
    development of chemotherapy resistance in ovarian cancer

        SABiosciences Custom PCR Arrays for NACC1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NACC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NACC1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NACC1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NACC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NACC1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008580371 nucleus accumbens-associated protein 1-like 82.71(n)
    89.47(a)
      100858037  XM_003643449.1  XP_003643497.1 
    lizard
    (Anolis carolinensis)
    Reptilia NACC16
    --
    85(a)
    1 ↔ 1
    GL343286.1(661065-669047)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101682 Transcribed sequence with moderate similarity to protein more 86.73(n)    BX750660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5720931 nucleus accumbens-associated protein 1-like 68.1(n)
    76.08(a)
      572093  XM_001922112.3  XP_001922147.2 


    ENSEMBL Gene Tree for NACC1 (if available)
    TreeFam Gene Tree for NACC1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NACC1 gene
    ZBTB222  ZBTB342  ZBTB62  ZBTB452  ZBTB92  NACC22  ZBTB432  ZBTB262  
    ZBTB122  ZBTB372  ZBTB202  
    18/25 SIMAP similar genes for NACC1 using alignment to 3 protein entries:     NACC1_HUMAN (see all proteins) (see all similar genes):
    ZBTB20    ZBTB22    ZBTB7C    BACH2    KLHL36    NACC2
    ZBTB14    ZBTB4    ZBTB16    KLHL2    ZBTB43    HIC1
    BCL6B    KLHL32    ZNF131    BCL6    ZBTB21    ZBTB38

    NACC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/336 NCBI SNPs in NACC1 are shown (see all 336    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839376741,2
    --13229824(+) CGTGTG/TGGGGC 1 -- int10--------
    rs1884204811,2
    --13229958(+) GTCGAA/GAGAGC 1 -- int10--------
    rs1490469241,2
    --13230084(+) GTTCCA/GTCTTT 1 -- int10--------
    rs1920970471,2
    --13230342(+) TTGTGG/TCCAGA 1 -- int10--------
    rs1841928321,2
    --13230362(+) TTCAAA/GCCTAG 1 -- int10--------
    rs1905358931,2
    --13230378(+) GGGACC/TTCACA 1 -- int10--------
    rs1173816661,2
    F--13230385(+) CACAGC/TAACCA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs753839401,2
    F--13230438(+) GAGCCT/GGAGTT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1431909641,2
    --13230439(+) AGCCTC/GAGTTC 1 -- int10--------
    rs756575251,2
    --13230461(+) TCCCTG/AGGGGT 1 -- int12Minor allele frequency- A:0.08CSA WA 120

    HapMap Linkage Disequilibrium report for NACC1 (13228917 - 13251959 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NACC1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NACC1
    DNA2.0 Custom Variant and Variant Library Synthesis for NACC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NACC1 for disorders           About GeneDecksing

    OMIM gene information: 610672    OMIM disorders: --

    11 diseases for NACC1:    About MalaCards
    serous cystadenocarcinoma    cystadenocarcinoma    hyperargininemia    endometrial carcinoma
    cervical carcinoma    ovarian carcinoma    cervicitis    ovarian cancer
    carcinoma    melanoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NACC1:
    Hyperargininemia

    Export disorders for NACC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NACC1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with NACC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions. (PubMed id 17391728)1, 2 Davidson B.... Shih I.-M. (2007)
    2. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PubMed id 17804717)1, 2 Nakayama K....Shih I.e.M. (2007)
    3. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. (PubMed id 17130457)1, 2 Nakayama K.... Shih I.-M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Nuclear localization signal in a cancer-related transc riptional regulator protein NAC1. (PubMed id 22665369)1 Okazaki K....Sakashita G. (2012)
    7. Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. (PubMed id 22653145)1 Rahman M.T....Miyazaki K. (2012)
    8. Biological and clinical significance of NAC1 expressio n in cervical carcinomas: a comparative study between squamous cell carcinomas a nd adenocarcinomas/adenosquamous carcinomas. (PubMed id 21889186)1 Yeasmin S....Miyazaki K. (2012)
    9. Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. (PubMed id 22665267)1 Zhang Y....Yang J.M. (2012)
    10. NAC1, a BTB/POZ protein overexpressed in uterine sarco mas. (PubMed id 22993327)1 Rahman M.T....Miyazaki K. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112939 HGNC: 20967 AceView: BTBD14B Ensembl:ENSG00000160877 euGenes: HUgn112939
    ECgene: NACC1 H-InvDB: NACC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NACC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NACC1 gene:
    Search GeneIP for patents involving NACC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NACC1   OriGene shRNA RFP for NACC1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NACC1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NACC1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NACC1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NACC1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NACC1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NACC1   OriGene Custom Protein Services for NACC1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NACC1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NACC1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NACC1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NACC1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NACC1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NACC1
     GenScript Custom Purified and Recombinant Proteins Services for NACC1 GenScript cDNA clones with any tag delivered in your preferred vector for NACC1
     GenScript Custom Assay Services for NACC1 GenScript Custom Superior Antibodies Services for NACC1
     GenScript Custom overexpressing Cell Line Services for NACC1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NACC1  (NAC1)

     Regulatory tfbs in NACC1 promoter
     Search Chromatin IP Primers for NACC1
     RT2 qPCR Primer Assay in human, mouse, rat NACC1
     Search GNC Networks for NACC1
     SABiosciences Custom PCR Arrays for NACC1
     Search Tocris compounds for NACC1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NACC1 antibodies
     Antibodies for NACC1
     See all of Abcam's Antibodies, Kits and Proteins for NACC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NACC1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NACC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC1
     SwitchGear 3'UTR luciferase reporter plasmids for NACC1
     SwitchGear Promoter luciferase reporter plasmids for NACC1
     ThermoFisher Antibody for NACC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NACC1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NACC1
    Sirion Biotech Customized:
     stable knockdown cell line services for NACC1
     inducible knockdown cell line services for NACC1
     design and validation of potent shRNA sequences against NACC1
     adenovirus for potent knockdown of NACC1
     adenovirus for overexpression of NACC1
     stable overexpressing cell line services for NACC1
     inducible overexpressing cell line services for NACC1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NACC1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4