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NACC1 Gene

protein-coding   GIFtS: 50
GCID: GC19P013229

Nucleus Accumbens Associated 1, BEN And BTB (POZ) Domain...

(Previous name: BTB (POZ) domain containing 14B)
(Previous symbol: BTBD14B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleus Accumbens Associated 1, BEN And BTB (POZ) Domain Containing1 2     BTB (POZ) Domain Containing 14B1
BTBD14B1 2 3     Nucleus Accumbens Associated 11
BEN Domain Containing 81 2     BEND82
NAC-12 3     BTBD302
NAC12 3     Nucleus Accumbens-Associated Protein 12
BTB/POZ Domain-Containing Protein 14B2 3     Transcriptional Repressor NAC12

External Ids:    HGNC: 209671   Entrez Gene: 1129392   Ensembl: ENSG000001608777   OMIM: 6106725   UniProtKB: Q96RE73   

Export aliases for NACC1 gene to outside databases

Previous GC identifers: GC19P013091 GC19P012818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NACC1 Gene:
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular
processes including proliferation, apoptosis and transcription regulation. The encoded protein is a
transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded
protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene
may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short
arm of chromosome 9. (provided by RefSeq, Feb 2012)

GeneCards Summary for NACC1 Gene:
NACC1 (nucleus accumbens associated 1, BEN and BTB (POZ) domain containing) is a protein-coding gene. Diseases associated with NACC1 include hyperargininemia, and serous cystadenocarcinoma. An important paralog of this gene is ZBTB34.

UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7
Function: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal
cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and
survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1.
Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines

Gene Wiki entry for NACC1 (BTBD14B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NACC1 gene promoter:
         AREB6   USF1   Spz1   AML1a   USF-1   c-Myb   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNACC1 promoter sequence
   Search Chromatin IP Primers for NACC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NACC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

NACC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013229:  view genomic region     (about GC identifiers)

Start:
13,228,917 bp from pter      End:
13,251,959 bp from pter
Size:
23,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7 (See protein sequence)
Recommended Name: Nucleus accumbens-associated protein 1  
Size: 527 amino acids; 57258 Da
Subunit: Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with
CUL3, PSMD7 AND RCOR1
1 PDB 3D structure from and Proteopedia for NACC1:
3GA1 (3D)    

Explore the universe of human proteins at neXtProt for NACC1: NX_Q96RE7

Explore proteomics data for NACC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NACC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443108.1  
    ENSEMBL proteins: 
     ENSP00000467120   ENSP00000292431   ENSP00000466017  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BEND: BEN domain containing
    BTBD: BTB/POZ domain containing

    4 InterPro protein domains:
     IPR018379 BEN_domain
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q96RE7

    ProtoNet protein and cluster: Q96RE7

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7
    Similarity: Contains 1 BEN domain
    Similarity: Contains 1 BTB (POZ) domain


    NACC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NACC1_HUMAN, Q96RE7
    Function: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal
    cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and
    survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1.
    Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NACC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NACC1:
     Decreased Hepatitis C virus re  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nacc1):
     behavior/neurological  homeostasis/metabolism  mortality/aging  reproductive system  skeleton 

    NACC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nacc1tm1.1Jlwa for NACC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NACC1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NACC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NACC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NACC1:
    hsa-mir-185-5p (MIRT045313), hsa-mir-218-5p (MIRT004542), hsa-mir-615-3p (MIRT040358)

    Block miRNA regulation of human, mouse, rat NACC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NACC1 (see all 61):
    hsa-miR-1914* hsa-miR-199a-3p hsa-let-7a-2* hsa-miR-218 hsa-miR-1244 hsa-miR-124 hsa-miR-9 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNACC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NACC1

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    GenScript: all cDNA clones in your preferred vector: NACC1 (NM_052876)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NACC1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NACC1_HUMAN, Q96RE7: Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016604nuclear body IDA17130457
    GO:0043231intracellular membrane-bounded organelle IDA--

    NACC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NACC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NACC1
        Neuroscience



    NACC1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NACC1
    Interactions:

        Search GeneGlobe Interaction Network for NACC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NACC1 (Q96RE72, 3 ENSP000002924314) via UniProtKB, MINT, STRING, and/or I2D (see all 804)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIF1Q5UIP02, 3, ENSP000002433264MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000243326
    WDR18Q9BV382, 3, ENSP000002512894MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000251289
    GATAD2BQ8WXI92, 3, ENSP000003576444MINT-7945693 I2D: score=2 STRING: ENSP00000357644
    MYBBP1AQ9BQG02, 3, ENSP000003709684MINT-7947479 I2D: score=2 STRING: ENSP00000370968
    SMARCC1Q929222, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0008284positive regulation of cell proliferation IMP17130457
    GO:0045892negative regulation of transcription, DNA-templated IMP17804717
    GO:0051260protein homooligomerization IDA17130457

    NACC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NACC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NACC1 gene: 
    NM_052876.3  

    Unigene Cluster for NACC1:

    Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
    Hs.531614  [show with all ESTs]
    Unigene Representative Sequence: NM_052876
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586171 ENST00000292431(uc002mwm.3) ENST00000585663
    miRNA
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    Block miRNA regulation of human, mouse, rat NACC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NACC1 (see all 61):
    hsa-miR-1914* hsa-miR-199a-3p hsa-let-7a-2* hsa-miR-218 hsa-miR-1244 hsa-miR-124 hsa-miR-9 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNACC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NACC1
    Predesigned siRNA for gene silencing in human, mouse, rat NACC1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NACC1 (NM_052876)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NACC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NACC1
    Primer
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    OriGene qPCR primer pairs and template standards for NACC1
    OriGene qSTAR qPCR primer pairs in human, mouse for NACC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NACC1
      QuantiTect SYBR Green Assays in human, mouse, rat NACC1
      QuantiFast Probe-based Assays in human, mouse, rat NACC1

    Additional mRNA sequence: 

    AF395817.1 AK094702.1 AK123056.1 AK226064.1 BC055396.1 

    9 DOTS entries:

    DT.438889  DT.95094570  DT.91740869  DT.100779374  DT.102832319  DT.121412308  DT.91662413  DT.121157120 
    DT.95364391 

    Selected AceView cDNA sequences (see all 146):

    BU507699 BE551636 NM_052876 AA031357 CR623895 AA314443 CA946320 AI659103 
    BU684970 BX956897 CA422474 AI633928 BQ219585 BU169499 AK094702 AI253160 
    BM458054 AF395817 BU507965 BU631034 BX448528 BM460634 BU508302 BG110290 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NACC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATATCAG
    NACC1 Expression
    About this image


    NACC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    NACC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NACC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531614

    UniProtKB/Swiss-Prot: NACC1_HUMAN, Q96RE7
    Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression
    levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in
    primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy,
    suggesting a role in development of chemotherapy resistance in ovarian cancer

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NACC1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nacc11 , 5 nucleus accumbens associated 1, BEN and BTB (POZ) domain more1, 5 84.21(n)1
    89.63(a)1
      8 (41.02 cM)5
    668301  NM_025788.31  NP_080064.31 
     846704835 
    lizard
    (Anolis carolinensis)
    Reptilia NACC16
    nucleus accumbens associated 1, BEN and BTB (POZ) ...
    82(a)
    1 ↔ 1
    GL343286.1(638409-669047)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101682 Transcribed sequence with moderate similarity to protein more 86.73(n)    BX750660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5720931 nucleus accumbens-associated protein 1-like 67.71(n)
    75.25(a)
      572093  XM_001922112.4  XP_001922147.3 


    ENSEMBL Gene Tree for NACC1 (if available)
    TreeFam Gene Tree for NACC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NACC1 gene
    ZBTB342  ZBTB222  ZBTB452  ZBTB62  ZBTB92  NACC22  ZBTB262  ZBTB432  
    ZBTB372  ZBTB122  ZBTB202  
    Selected SIMAP similar genes for NACC1 using alignment to 3 protein entries:     NACC1_HUMAN (see all proteins) (see all similar genes):
    ZBTB20    ZBTB22    ZBTB7C    BACH2    KLHL36    NACC2
    ZBTB14    ZBTB4    ZBTB45    ZBTB16    KLHL2    ZBTB43
    HIC1    BCL6B    KLHL32    ZNF131    BCL6    ZBTB21

    NACC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NACC1 (see all 441)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839376741,2
    --13229824(+) CGTGTG/TGGGGC 1 -- int10--------
    rs1884204811,2
    --13229958(+) GTCGAA/GAGAGC 1 -- int10--------
    rs1490469241,2
    --13230084(+) GTTCCA/GTCTTT 1 -- int10--------
    rs1920970471,2
    --13230342(+) TTGTGG/TCCAGA 1 -- int10--------
    rs1841928321,2
    --13230362(+) TTCAAA/GCCTAG 1 -- int10--------
    rs1905358931,2
    --13230378(+) GGGACC/TTCACA 1 -- int10--------
    rs1173816661,2
    F--13230385(+) CACAGC/TAACCA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs753839401,2
    C,F--13230438(+) GAGCCT/GGAGTT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1431909641,2
    --13230439(+) AGCCTC/GAGTTC 1 -- int10--------
    rs756575251,2
    C,F--13230461(+) TCCCTG/AGGGGT 1 -- int12Minor allele frequency- A:0.08CSA WA 120

    HapMap Linkage Disequilibrium report for NACC1 (13228917 - 13251959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NACC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911087CNV Loss21882294
    nsv911086CNV Loss21882294
    dgv3737n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610672    OMIM disorders: --

    Selected diseases for NACC1 (see all 22):    
    About MalaCards
    hyperargininemia    serous cystadenocarcinoma    adenosquamous carcinoma    uterine sarcoma
    cystadenocarcinoma    pancreatic ductal adenocarcinoma    endometrial carcinoma    lateral sclerosis
    amyotrophic lateral sclerosis    ovarian cancer    cervicitis    sarcoma
    tonsillitis    squamous cell carcinoma    obesity    melanoma
    adenocarcinoma    thyroiditis    pancreatitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for NACC1:
    Hyperargininemia

    NACC1 for disorders           About GeneDecksing


    Export disorders for NACC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NACC1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with NACC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human Nac1 POZ domain. (PubMed id 19407373)1, 2 Stead M.A.... Wright S.C. (Acta Crystallogr. F 2009)
    2. Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions. (PubMed id 17391728)1, 2 Davidson B.... Shih I.-M. (Hum. Pathol. 2007)
    3. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PubMed id 17804717)1, 2 Nakayama K.... Shih I.-M. (Cancer Res. 2007)
    4. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. (PubMed id 17130457)1, 2 Nakayama K.... Shih I.-M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson's disease. (PubMed id 24231739)1 Korutla L....Mackler S.A. (Neuroscience 2014)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. Nuclear localization signal in a cancer-related transcriptional regulator protein NAC1. (PubMed id 22665369)1 Okazaki K....Sakashita G. (Carcinogenesis 2012)
    10. Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. (PubMed id 22653145)1 Rahman M.T....Miyazaki K. (Br. J. Cancer 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112939 HGNC: 20967 AceView: BTBD14B Ensembl:ENSG00000160877 euGenes: HUgn112939
    ECgene: NACC1 H-InvDB: NACC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NACC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NACC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NACC1 gene:
    Search GeneIP for patents involving NACC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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