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Aliases for NACC1 Gene

Aliases for NACC1 Gene

  • Nucleus Accumbens Associated 1 2 2 3 5
  • Nucleus Accumbens Associated 1, BEN And BTB (POZ) Domain Containing 2 3
  • BTB/POZ Domain-Containing Protein 14B 3 4
  • BEN Domain Containing 8 2 3
  • BTBD14B 3 4
  • NAC-1 3 4
  • NAC1 3 4
  • Nucleus Accumbens-Associated Protein 1 3
  • BTB (POZ) Domain Containing 14B 2
  • Transcriptional Repressor NAC1 3
  • BTBD30 3
  • BEND8 3
  • NECFM 3

External Ids for NACC1 Gene

Previous HGNC Symbols for NACC1 Gene

  • BTBD14B

Previous GeneCards Identifiers for NACC1 Gene

  • GC19P013091
  • GC19P013229
  • GC19P012818

Summaries for NACC1 Gene

Entrez Gene Summary for NACC1 Gene

  • This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]

GeneCards Summary for NACC1 Gene

NACC1 (Nucleus Accumbens Associated 1) is a Protein Coding gene. Diseases associated with NACC1 include Argininemia. Among its related pathways are Neuroscience. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for NACC1 Gene

  • Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

Gene Wiki entry for NACC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACC1 Gene

Genomics for NACC1 Gene

Regulatory Elements for NACC1 Gene

Enhancers for NACC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G013050 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.7 -60.6 -60570 12.1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF844 ZNF625 RPS6P25 ZNF136 ZNF442 LYL1 NACC1 TRMT1 CCDC130 ZNF799
GH19G013011 2 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -96.7 -96653 17.2 HDGF PKNOX1 FOXA2 CREB3L1 MLX ARNT AGO1 SIN3A ARID4B FEZF1 TRMT1 ZNF709 ZNF788 ZNF625 ZNF136 NFIX CCDC130 ZNF564 ZNF791 DAND5
GH19G013030 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 -82.4 -82422 8.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 TRMT1 ZNF791 STX10 ZNF136 ZNF844 ZNF442 RPS6P25 NFIX MRI1 DAND5
GH19G013042 1.8 FANTOM5 ENCODE dbSUPER 12.4 -72.9 -72875 3.0 AGO1 YY1 ZNF143 ZNF416 ZNF263 SP3 TBX21 MEF2D ZFP41 GLIS1 TRMT1 ZNF136 CCDC130 ZNF564 ZNF791 ZNF788 ZNF442 ZNF44 WDR83OS ZNF709
GH19G013068 1.3 ENCODE dbSUPER 13.2 -47.0 -47010 3.3 HDGF PKNOX1 ATF1 CREB3L1 ARNT E2F7 YY1 TCF12 ZNF766 ELK1 LYL1 NACC1 TRMT1 IER2 STX10 ENSG00000267610 PIR45233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NACC1 on UCSC Golden Path with GeneCards custom track

Promoters for NACC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107379 753 3201 CREB3L1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610

Genomic Location for NACC1 Gene

Chromosome:
19
Start:
13,116,847 bp from pter
End:
13,141,147 bp from pter
Size:
24,301 bases
Orientation:
Plus strand

Genomic View for NACC1 Gene

Genes around NACC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACC1 Gene

Proteins for NACC1 Gene

  • Protein details for NACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RE7-NACC1_HUMAN
    Recommended name:
    Nucleus accumbens-associated protein 1
    Protein Accession:
    Q96RE7

    Protein attributes for NACC1 Gene

    Size:
    527 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.

    Three dimensional structures from OCA and Proteopedia for NACC1 Gene

neXtProt entry for NACC1 Gene

Post-translational modifications for NACC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NACC1 (NAC1)
  • Abcam antibodies for NACC1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NACC1

No data available for DME Specific Peptides for NACC1 Gene

Domains & Families for NACC1 Gene

Gene Families for NACC1 Gene

Protein Domains for NACC1 Gene

Suggested Antigen Peptide Sequences for NACC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NACC1: view

No data available for UniProtKB/Swiss-Prot for NACC1 Gene

Function for NACC1 Gene

Molecular function for NACC1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
genes like me logo Genes that share phenotypes with NACC1: view

Animal Models for NACC1 Gene

MGI Knock Outs for NACC1:

Animal Model Products

miRNA for NACC1 Gene

miRTarBase miRNAs that target NACC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NACC1 Gene

Localization for NACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACC1 Gene

Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NACC1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17391728
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016604 nuclear body IDA 17130457
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with NACC1: view

Pathways & Interactions for NACC1 Gene

SuperPathways for NACC1 Gene

SuperPathway Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with NACC1: view

Pathways by source for NACC1 Gene

1 Cell Signaling Technology pathway for NACC1 Gene

Gene Ontology (GO) - Biological Process for NACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IMP 17130457
GO:0045892 negative regulation of transcription, DNA-templated IMP 17804717
GO:0051260 protein homooligomerization IDA 17130457
genes like me logo Genes that share ontologies with NACC1: view

No data available for SIGNOR curated interactions for NACC1 Gene

Transcripts for NACC1 Gene

Unigene Clusters for NACC1 Gene

Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NACC1 Gene

No ASD Table

Relevant External Links for NACC1 Gene

GeneLoc Exon Structure for
NACC1
ECgene alternative splicing isoforms for
NACC1

Expression for NACC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NACC1 Gene

This gene is overexpressed in CD8 Tcells (20.9), CD4 Tcells (10.2), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NACC1 Gene



Protein tissue co-expression partners for NACC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NACC1 Gene:

NACC1

SOURCE GeneReport for Unigene cluster for NACC1 Gene:

Hs.531614

mRNA Expression by UniProt/SwissProt for NACC1 Gene:

Q96RE7-NACC1_HUMAN
Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.

Evidence on tissue expression from TISSUES for NACC1 Gene

  • Eye(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with NACC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NACC1 Gene

Orthologs for NACC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NACC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACC1 34 35
  • 99.56 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NACC1 34 35
  • 87.98 (n)
dog
(Canis familiaris)
Mammalia NACC1 34 35
  • 87.47 (n)
rat
(Rattus norvegicus)
Mammalia Nacc1 34
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Nacc1 34 16 35
  • 84.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NACC1 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NACC1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nacc1 34
  • 77.57 (n)
Str.10168 34
zebrafish
(Danio rerio)
Actinopterygii LOC572093 34
  • 67.71 (n)
NACC1 35
  • 65 (a)
OneToOne
Species where no ortholog for NACC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NACC1 Gene

ENSEMBL:
Gene Tree for NACC1 (if available)
TreeFam:
Gene Tree for NACC1 (if available)

Paralogs for NACC1 Gene

genes like me logo Genes that share paralogs with NACC1: view

Variants for NACC1 Gene

Sequence variations from dbSNP and Humsavar for NACC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000002684 -- 13,126,063(+) TTTTT(-/A)AGACG intron-variant
rs1000118341 -- 13,125,786(+) CCAGC(C/T)TAGAG intron-variant
rs1000317587 -- 13,115,551(+) CTCCT(A/T)TAGCT intron-variant, upstream-variant-2KB
rs1000433615 -- 13,115,278(+) ACCTA(A/C)CGGGC upstream-variant-2KB, splice-donor-variant
rs1000492182 -- 13,131,829(+) GGGGC(A/G)GCAGA intron-variant

Variation tolerance for NACC1 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NACC1 Gene

Human Gene Mutation Database (HGMD)
NACC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NACC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NACC1 Gene

Disorders for NACC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NACC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
argininemia
  • hyperargininemia
- elite association - COSMIC cancer census association via MalaCards
Search NACC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NACC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NACC1
genes like me logo Genes that share disorders with NACC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NACC1 Gene

Publications for NACC1 Gene

  1. Structure of the human Nac1 POZ domain. (PMID: 19407373) Stead M.A. … Wright S.C. (Acta Crystallogr. F 2009) 3 4 64
  2. Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions. (PMID: 17391728) Davidson B. … Shih I.-M. (Hum. Pathol. 2007) 3 4 64
  3. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PMID: 17804717) Nakayama K. … Shih I.-M. (Cancer Res. 2007) 3 4 64
  4. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. (PMID: 17130457) Nakayama K. … Shih I.-M. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NACC1 Gene

Sources for NACC1 Gene

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