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NACAP1 Gene

pseudogene   GIFtS: 30
GCID: GC08P102376

Nascent-Polypeptide-Associated Complex Alpha Polypeptide...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nascent-Polypeptide-Associated Complex Alpha Polypeptide Pseudogene
11 2
Alpha-NAC Pseudogene 13
NAC-Alpha Pseudogene 13

External Ids:    HGNC: 246881   Entrez Gene: 839552   Ensembl: ENSG000002282247   UniProtKB: Q9BZK33   

Export aliases for NACAP1 gene to outside databases

Previous GC identifers: GC08P102451 GC08P097580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NACAP1 Gene:
NACAP1 (nascent-polypeptide-associated complex alpha polypeptide pseudogene 1) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NACAP1 gene promoter:
         AhR   USF1   NF-1   E4BP4   YY1   Arnt   C/EBPalpha   AREB6   USF-1   HFH-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NACAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NACAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

NACAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACAP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P102376:  view genomic region     (about GC identifiers)

Start:
102,374,022 bp from pter      End:
102,384,935 bp from pter
Size:
10,914 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NACP1_HUMAN, Q9BZK3 (See protein sequence)
Recommended Name: Putative nascent polypeptide-associated complex subunit alpha-like protein  
Size: 213 amino acids; 23306 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NACAP1: NX_Q9BZK3

Explore proteomics data for NACAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NACAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    Search eBioscience for ELISAs for NACAP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016641 EGD2/NACA
     IPR002715 Nas_poly-pep-assoc_cplx_dom

    Graphical View of Domain Structure for InterPro Entry Q9BZK3

    ProtoNet protein and cluster: Q9BZK3

    UniProtKB/Swiss-Prot: NACP1_HUMAN, Q9BZK3
    Similarity: Belongs to the NAC-alpha family
    Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with NACAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NACAP1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NACAP1
    Interactions:

        Search GeneGlobe Interaction Network for NACAP1

    Selected Interacting proteins for NACAP1 (Q9BZK33) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NACAP1 (NACP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NACAP1 gene: 
    NM_032031.1  

    Unigene Cluster for NACAP1:

    Nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
    Hs.567608  [show with all ESTs]
    Unigene Representative Sequence: AK291701
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419462(uc010mbs.1) ENST00000519039(uc003ykc.1)
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      QuantiFast Probe-based Assays in human, mouse, rat NACAP1

    Additional mRNA sequence: 

    AF315951.1 AK291701.1 BC069062.1 BC069411.1 BC069542.1 BC074958.2 BC074959.2 NR_002182.1 

    4 DOTS entries:

    DT.75122835  DT.121470534  DT.100889874  DT.100889890 

    5 AceView cDNA sequences:

    BC074958 BC069411 BC074959 AL040169 BC069542 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NACAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTTGGGG
    NACAP1 Expression
    About this image

    NACAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NACAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567608
        Custom PCR Arrays for NACAP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NACAP1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    soybean
    (Glycine max)
    eudicotyledons Gma.99672 Transcribed sequence with moderate similarity to protein more 73.55(n)  


    ENSEMBL Gene Tree for NACAP1 (if available)
    TreeFam Gene Tree for NACAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NACAP1 gene
    3 SIMAP similar genes for NACAP1 using alignment to 1 protein entry:     NACP1_HUMAN:
    NACA    NACA2    NACAD

    Find genes that share paralogs with NACAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NACAP1 (see all 78)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877669141,2
    --102379175(+) TTTCAA/GTTGTT 1 -- us2k10--------
    rs1923395961,2
    --102379178(+) CAATTC/GTTCTG 1 -- us2k10--------
    rs760303511,2
    C,F--102379196(+) GGTGCG/AACTGC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1822555291,2
    --102379255(+) TGCTGA/GAAGAG 1 -- us2k10--------
    rs1865670481,2
    --102379284(+) AATGTG/TTTGGA 1 -- us2k10--------
    rs101004331,2
    C,F,A,H--102379297(+) CCCATG/AATCTC 1 -- us2k117Minor allele frequency- A:0.18NS EA NA WA CSA 1969
    rs732841011,2
    C,F--102379317(+) GTTTTG/TCCAGT 1 -- us2k12Minor allele frequency- T:0.01WA 120
    rs736993091,2
    C,F--102379340(+) GTAGGG/TGCAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1388782761,2
    C--102379420(+) TTATAG/TATAAT 1 -- us2k10--------
    rs1850292761,2
    --102379498(+) TGGTCA/GTTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NACAP1 (102374022 - 102384935 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NACAP1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NACAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NACAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with NACAP1           About GenesLikeMe

    Genetic Association Database (GAD): NACAP1

    Export disorders for NACAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NACAP1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NACAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)1 Waaijers S....Boxem M. (J. Proteome Res. 2013)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    3. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83955 HGNC: 24688 AceView: FKSG17 Ensembl:ENSG00000228224 euGenes: HUgn83955
    ECgene: NACAP1 H-InvDB: NACAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NACAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NACAP1 gene:
    Search GeneIP for patents involving NACAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NACAP1
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACAP1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NACAP1
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     Search ThermoFisher Antibodies for NACAP1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NACAP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NACAP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NACAP1
     Search LSBio for Antibodies for NACAP1
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     Browse compounds at ApexBio
     Search Addgene for plasmids for NACAP1
      Search eBioscience for proteins for NACAP1
      Search eBioscience for elisas for NACAP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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