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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NACAP1 Gene

pseudogene GIFtS: 31
GCID: GC08P102376

nascent-polypeptide-associated complex alpha polypeptide...

Search for NACAP1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nascent-Polypeptide-Associated Complex Alpha Polypeptide Pseudogene 1¹ ²
FKSG17¹
Alpha-NAC Pseudogene 1³
NAC-Alpha Pseudogene 1³

External Ids:	HGNC: 24688¹	Entrez Gene: 83955²	Ensembl: ENSG00000228224⁷	UniProtKB: Q9BZK3³

Export aliases for NACAP1 gene to outside databases

Previous GC identifers: GC08P102451 GC08P097580

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NACAP1 gene promoter:
AhR USF1 NF-1 E4BP4 YY1 Arnt C/EBPalpha AREB6 USF-1 HFH-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NACAP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NACAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3

NACAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACAP1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P102376: view genomic region (about GC identifiers)

Start:	102,374,022 bp from pter	End:	102,384,935 bp from pter
Size:	10,914 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NACP1_HUMAN, Q9BZK3 (See protein sequence)

Recommended Name: Putative nascent polypeptide-associated complex subunit alpha-like protein

Size: 213 amino acids; 23306 Da

Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NACAP1: NX_Q9BZK3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZK3

NACAP1 Protein expression data from MOPED and PaxDb: About this image

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NACAP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR016641 EGD2/NACA

IPR002715 Nas_poly-pep-assoc_cplx_dom

Graphical View of Domain Structure for InterPro Entry Q9BZK3

ProtoNet protein and cluster: Q9BZK3

UniProtKB/Swiss-Prot: NACP1_HUMAN, Q9BZK3

Similarity: Belongs to the NAC-alpha family

Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain

Similarity: Contains 1 UBA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NACAP1

5/9 Interacting proteins for NACAP1 (Q9BZK3³) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP17L24	Q0WX57³	I2D: score=1
USP17L25	Q0WX57³	I2D: score=1
USP17L26	Q0WX57³	I2D: score=1
USP17L27	Q0WX57³	I2D: score=1
USP17L28	Q0WX57³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NACAP1
Search CenterWatch for drugs/clinical trials and news about NACAP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NACAP1 gene:

NM_032031.1

Unigene Cluster for NACAP1:

Nascent-polypeptide-associated complex alpha polypeptide pseudogene 1

Hs.567608 [show with all ESTs]

Unigene Representative Sequence: AK291701

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419462(uc010mbs.1) ENST00000519039(uc003ykc.1)

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Additional cDNA sequence:

AF315951.1 AK291701.1 BC069062.1 BC069411.1 BC069542.1 BC074958.2 BC074959.2 NR_002182.1

4 DOTS entries:

DT.75122835 DT.121470534 DT.100889874 DT.100889890

5 AceView cDNA sequences:

BC069411 BC074958 BC074959 BC069542 AL040169

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NACAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTTGGGG

About this image

NACAP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NACAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NACAP1

SOURCE GeneReport for Unigene cluster: Hs.567608

SABiosciences Custom PCR Arrays for NACAP1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACAP1 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
soybean (Glycine max)	eudicotyledons	Gma.9967²	Transcribed sequence with moderate similarity to protein more	73.55(n)

Species with no ortholog for NACAP1

ENSEMBL Gene Tree for NACAP1 (if available)
TreeFam Gene Tree for NACAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187766914^1,2		--	102379175(+)	`TTTCAA/GTTGTT`	1	--	us2k¹		0	--	--	--	--
rs192339596^1,2		--	102379178(+)	`CAATTC/GTTCTG`	1	--	us2k¹		0	--	--	--	--
rs76030351^1,2	F,	--	102379196(+)	`GGTGCG/AACTGC`	1	--	us2k¹		1		WA	118
rs182255529^1,2		--	102379255(+)	`TGCTGA/GAAGAG`	1	--	us2k¹		0	--	--	--	--
rs186567048^1,2		--	102379284(+)	`AATGTG/TTTGGA`	1	--	us2k¹		0	--	--	--	--
rs10100433^1,2	C,F,A,H,	--	102379297(+)	`CCCATG/AATCTC`	1	--	us2k¹		17		NS EA NA WA CSA	1969
rs73284101^1,2	C,	--	102379317(+)	`GTTTTG/TCCAGT`	1	--	us2k¹		2		WA	120
rs73699309^1,2	C,	--	102379340(+)	`GTAGGG/TGCAGT`	1	--	us2k¹		1		WA	2
rs138878276^1,2		--	102379420(+)	`TTATAG/TATAAT`	1	--	us2k¹		0	--	--	--	--
rs185029276^1,2		--	102379498(+)	`TGGTCA/GTTTGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NACAP1 (102374022 - 102384935 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NACAP1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NACAP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NACAP1)

Utopia: connect your pdf to the dynamic
world of online information

A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S....Dorf M.E. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83955	HGNC: 24688	AceView: FKSG17	Ensembl:ENSG00000228224	euGenes: HUgn83955
ECgene: NACAP1	H-InvDB: NACAP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NACAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NACAP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NACAP1 gene:
Search GeneIP for patents involving NACAP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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NACAP1 Gene

nascent-polypeptide-associated complex alpha polypeptide...

Aliases
for NACAP1 gene

Summaries
for NACAP1 gene

Genomic Views
for NACAP1 gene

Proteins
for NACAP1 gene

Protein Domains /
Families
for NACAP1 gene

Function
for NACAP1 gene

Pathways & Interactions
for NACAP1 gene

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for NACAP1 gene

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NACAP1 Gene

nascent-polypeptide-associated complex alpha polypeptide...

Aliasesfor NACAP1 gene

Summariesfor NACAP1 gene

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Proteinsfor NACAP1 gene

Protein Domains /Familiesfor NACAP1 gene

Functionfor NACAP1 gene

Pathways & Interactionsfor NACAP1 gene

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Transcriptsfor NACAP1 gene

Expression for NACAP1 gene

Orthologsfor NACAP1 gene

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Genome Databases showing NACAP1 gene

Other Databases showing NACAP1 gene

Specialized Databases showing NACAP1 gene

Intellectual Propertyfor NACAP1 gene

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View Random Gene

Aliases
for NACAP1 gene

Summaries
for NACAP1 gene

Genomic Views
for NACAP1 gene

Proteins
for NACAP1 gene

Protein Domains /
Families
for NACAP1 gene

Function
for NACAP1 gene

Pathways & Interactions
for NACAP1 gene

Drugs & Compounds
for NACAP1 gene

Transcripts
for NACAP1 gene

Expression
for NACAP1 gene

Orthologs
for NACAP1 gene

Paralogs
for NACAP1 gene

Genomic Variants
for NACAP1 gene

Disorders / Diseases
for NACAP1 gene

Publications
for NACAP1 gene

Intellectual Property
for NACAP1 gene

Products
for NACAP1 gene