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NACAD Gene

protein-coding   GIFtS: 42
GCID: GC07M045120

NAC Alpha Domain Containing

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NAC Alpha Domain Containing1 2
NAC-Alpha Domain-Containing Protein 12
KIAA03633

External Ids:    HGNC: 221961   Entrez Gene: 231482   Ensembl: ENSG000001362747   UniProtKB: O150693   

Export aliases for NACAD gene to outside databases

Previous GC identifers: GC07M045087 GC07M045067 GC07M045004


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NACAD Gene:
NACAD (NAC alpha domain containing) is a protein-coding gene. Diseases associated with NACAD include cblc, and cervicitis. An important paralog of this gene is NACA.

UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069
Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May
bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal
recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the
inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NACAD gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   NF-kappaB   HEN1   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NACAD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NACAD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

NACAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACAD gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M045120:  view genomic region     (about GC identifiers)

Start:
45,120,036 bp from pter      End:
45,128,513 bp from pter
Size:
8,478 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 45,159,326-45,167,663     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069 (See protein sequence)
Recommended Name: NAC-alpha domain-containing protein 1  
Size: 1562 amino acids; 161101 Da

Explore the universe of human proteins at neXtProt for NACAD: NX_O15069

Explore proteomics data for NACAD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NACAD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001139806.1  
    ENSEMBL proteins: 
     ENSP00000420477  

    NACAD Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

    NACAD Antibody Products:

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    Novus Biologicals NACAD Antibody
    Search for Antibodies for NACAD at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for NACAD
    LSBio Antibodies in human, mouse, rat for NACAD

    NACAD Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NACAD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016641 EGD2/NACA
     IPR002715 Nas_poly-pep-assoc_cplx_dom

    Graphical View of Domain Structure for InterPro Entry O15069

    ProtoNet protein and cluster: O15069

    UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069
    Similarity: Belongs to the NAC-alpha family
    Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain


    NACAD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NACAD_HUMAN, O15069
    Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May
    bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal
    recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the
    inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for NACAD:

     Decreased cell number and incr 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NACAD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NACAD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NACAD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NACAD

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NACAD

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NACAD

    Clone
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    OriGene ORF clones in mouse, rat for NACAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NACAD (NM_001146334)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NACAD
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NACAD

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACAD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NACAD_HUMAN, O15069: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    NACAD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NACAD
    Interactions:

        Search GeneGlobe Interaction Network for NACAD

    Selected Interacting proteins for NACAD (O150692, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLCQ9ULV82, 3MINT-8250690 I2D: score=2 
    HDAC6Q9UBN72, 3MINT-8258054 I2D: score=2 
    MAP4K2Q128512, 3MINT-8260438 I2D: score=2 
    NR4A1P227362, 3MINT-8264072 I2D: score=2 
    PTK2Q053972, 3MINT-8267605 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    NACAD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NACAD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NACAD gene: 
    NM_001146334.1  

    Unigene Cluster for NACAD:

    NAC alpha domain containing
    Hs.96633  [show with all ESTs]
    Unigene Representative Sequence: NM_001146334
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490531(uc003tmt.3) ENST00000460409
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate NACAD
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat NACAD
    Clone
    Products:
         
    OriGene clones in human, mouse for NACAD (see all 6)
    OriGene ORF clones in mouse, rat for NACAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NACAD (NM_001146334)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NACAD
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NACAD
    Primer
    Products:
        
    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NACAD
      QuantiTect SYBR Green Assays in human, mouse, rat NACAD
      QuantiFast Probe-based Assays in human, mouse, rat NACAD

    Additional mRNA sequence: AB002361.1 

    3 DOTS entries:

    DT.109423  DT.100658926  DT.97787649 

    Selected AceView cDNA sequences (see all 64):

    AB002361 AL119753 BE645604 CD675048 BM728120 AA297699 BM680676 BM723495 
    BM681033 BM727592 BF528737 AV726228 BM700205 BG913099 BM696401 BU682625 
    BX411309 BP431048 BU553885 BM669143 CF132683 BM048833 BM313707 BQ614463 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NACAD expression in normal human tissues (normalized intensities)      NACAD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCCACTGA
    NACAD Expression
    About this image


    NACAD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Eye (Sensory Organs)
             Retina
    NACAD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NACAD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.96633
        Custom PCR Arrays for NACAD
    Primer
    Products:
    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NACAD
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    QuantiFast Probe-based Assays in human, mouse, rat NACAD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACAD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NACAD gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nacad5 NAC alpha domain containing   --   11 (4.60 cM) 6597823 
    chicken
    (Gallus gallus)
    Aves NACAD6
    NAC alpha domain containing
    26(a)
    1 ↔ 1
    2(4003122-4008985)
    lizard
    (Anolis carolinensis)
    Reptilia NACAD6
    NAC alpha domain containing
    66(a)
    1 ↔ 1
    AAWZ02040392(2124-3349)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.321732 Xenopus laevis transcribed sequence with moderate similarity more 82.68(n)    BJ641912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nacad6
    NAC alpha domain containing
    16(a)
    1 ↔ 1
    16(29852634-29869234) ENSDARG00000012347
    fruit fly
    (Drosophila melanogaster)
    Insecta Nacalpha6
    Nascent polypeptide associated complex protein alp...
    51(a)
    1 → many
    2R(8647198-8648377)
    worm
    (Caenorhabditis elegans)
    Secernentea icd-26
    Protein ICD-2, isoform a (icd-2) mRNA, complete cd...
    50(a)
    1 → many
    I(535791-536670) WBGene00022042
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EGD26
    Alpha subunit of the heteromeric nascent polypepti...
    37(a)
    1 → many
    VIII(487712-488236) YHR193C
    soybean
    (Glycine max)
    eudicotyledons 467218022   -- 73.11(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.90742 Oryza sativa (japonica cultivar-group) isolate 20527 more 77.36(n)    AK099300.1 


    ENSEMBL Gene Tree for NACAD (if available)
    TreeFam Gene Tree for NACAD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NACAD gene
    NACA2  NACA22  
    3 SIMAP similar genes for NACAD using alignment to 1 protein entry:     NACAD_HUMAN:
    NACA    NACAP1    NACA2

    NACAD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NACAD (see all 180)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480819011,2
    --45121817(+) AGATCG/TGCAAG 2 Q P mis10--------
    rs1121564231,2
    C--45121848(+) GGAGGT/CCACCT 2 /T /A mis11Minor allele frequency- C:0.00CSA 1
    rs1814267021,2
    --45121864(+) CTGAGA/GAGTGG 2 L syn10--------
    rs1866793751,2
    --45122188(+) CTGGGC/TACTTC 2 V syn10--------
    rs37354931,2,,4
    C,F,A,H--45122324(+) CTGGGC/AAGGAG 2 /C /F mis1 ese321Minor allele frequency- A:0.09EA NS NA 3760
    rs102431851,2,,4
    C,F,A,H--45122464(+) GGCGCA/CTCGGG 2 E D mis1 ese315Minor allele frequency- C:0.43NA EA NS WA CSA EU 1048
    rs2006781801,2
    C--45122472(+) GGGGAC/GCTCCC 2 L V mis10--------
    rs1903389401,2
    --45122601(+) ACCTGG/TGTGCG 2 T P mis10--------
    rs1140894811,2
    C,F--45122611(+) GCTCGC/AGCTTC 2 /A syn11Minor allele frequency- A:0.03WA 118
    rs1135588751,2
    C,F--45122612(+) CTCGCG/ACTTCC 2 /A /V mis11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for NACAD (45120036 - 45128513 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NACAD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1076637CNV Deletion17803354
    nsv888001CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NACAD
    DNA2.0 Custom Variant and Variant Library Synthesis for NACAD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for NACAD:    About MalaCards
    cblc    cervicitis


    NACAD for disorders           About GeneDecksing


    Export disorders for NACAD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NACAD gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NACAD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23148 HGNC: 22196 AceView: KIAA0363 Ensembl:ENSG00000136274 euGenes: HUgn23148
    ECgene: NACAD H-InvDB: NACAD

    (According to HUGE)
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    HUGE: KIAA0363

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NACAD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NACAD gene:
    Search GeneIP for patents involving NACAD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NACAD   OriGene RNAi products in human, mouse, rat for NACAD  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NACAD  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NACAD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NACAD   OriGene Custom Protein Services for NACAD  

     
     
     Block miRNA regulation of human, mouse, rat NACAD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NACAD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NACAD Predesigned siRNA for gene silencing in human, mouse, rat NACAD
     QuantiFast Probe-based Assays in human, mouse, rat NACAD QuantiTect SYBR Green Assays in human, mouse, rat NACAD
     Custom PCR Arrays for NACAD Search Chromatin IP Primers for NACAD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NACAD  Search GeneGlobe Interaction Network for NACAD
     Regulatory tfbs in NACAD promoter
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Search Tocris compounds for NACAD
     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for NACAD at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NACAD
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NACAD
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NACAD
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NACAD
     Browse SwitchGear Promoter luciferase reporter plasmids for NACAD
     Search ThermoFisher Antibodies for NACAD
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NACAD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NACAD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NACAD
     LSBio Antibodies in human, mouse, rat for NACAD
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
           
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