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Aliases for NACAD Gene

Aliases for NACAD Gene

  • NAC Alpha Domain Containing 2 3 5
  • KIAA0363 4

External Ids for NACAD Gene

Previous GeneCards Identifiers for NACAD Gene

  • GC07M045087
  • GC07M045067
  • GC07M045004
  • GC07M045120

Summaries for NACAD Gene

GeneCards Summary for NACAD Gene

NACAD (NAC Alpha Domain Containing) is a Protein Coding gene. An important paralog of this gene is NACA.

UniProtKB/Swiss-Prot for NACAD Gene

  • May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACAD Gene

Genomics for NACAD Gene

Regulatory Elements for NACAD Gene

Enhancers for NACAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G044628 2 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +453.8 453757 13.6 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A ARID4B FEZF1 YY1 ZNF766 ZNF143 PURB OGDH NACAD MYO1G ENSG00000228596 H2AFV LINC01952 DDX56 NUDCD3 PPIA
GH07G045108 1.2 ENCODE 25.6 -22.0 -21974 4.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 NACAD SNHG15 CCM2 TBRG4 RAMP3 SNORA5B
GH07G045087 1.5 FANTOM5 ENCODE dbSUPER 18.9 0.0 -2 2.4 HDAC1 PKNOX1 ATF1 ZNF76 KLF17 BMI1 ZBTB40 GLIS2 EGR1 SCRT2 NACAD TBRG4 ADCY1 PIR44785 GC07M045104 GC07M045132 GC07M045136 SNORA5A
GH07G045035 1.2 Ensembl ENCODE dbSUPER 16.1 +52.3 52303 1.5 ELF3 SOX5 SOX13 GATAD2A SCRT1 FOXA2 SAP130 SP5 FOXA3 ZSCAN9 ENSG00000260997 NACAD MYO1G CCM2 ENSG00000228596 SNHG15 GC07M045025 GC07P045063
GH07G044175 0.8 dbSUPER 18.8 +911.9 911908 3.3 ARID4B ZEB1 GLIS2 SCRT2 FOS ZEB2 ZNF398 ZNF843 NR2F2 PRDM6 NACAD DDX56 PURB GCK URGCP YKT6 LOC105375257
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NACAD on UCSC Golden Path with GeneCards custom track

Promoters for NACAD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211915 -39 1201 HDAC1 PKNOX1 ATF1 ZNF76 KLF17 BMI1 ZBTB40 GLIS2 EGR1 SCRT2

Genomic Location for NACAD Gene

Chromosome:
7
Start:
45,080,437 bp from pter
End:
45,088,961 bp from pter
Size:
8,525 bases
Orientation:
Minus strand

Genomic View for NACAD Gene

Genes around NACAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACAD Gene

Proteins for NACAD Gene

  • Protein details for NACAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15069-NACAD_HUMAN
    Recommended name:
    NAC-alpha domain-containing protein 1
    Protein Accession:
    O15069

    Protein attributes for NACAD Gene

    Size:
    1562 amino acids
    Molecular mass:
    161101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NACAD Gene

Post-translational modifications for NACAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACAD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NACAD
  • Santa Cruz Biotechnology (SCBT) Antibodies for NACAD

No data available for DME Specific Peptides for NACAD Gene

Domains & Families for NACAD Gene

Protein Domains for NACAD Gene

Suggested Antigen Peptide Sequences for NACAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15069

UniProtKB/Swiss-Prot:

NACAD_HUMAN :
  • Belongs to the NAC-alpha family.
Family:
  • Belongs to the NAC-alpha family.
genes like me logo Genes that share domains with NACAD: view

No data available for Gene Families for NACAD Gene

Function for NACAD Gene

Molecular function for NACAD Gene

UniProtKB/Swiss-Prot Function:
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
genes like me logo Genes that share phenotypes with NACAD: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NACAD Gene

Localization for NACAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACAD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NACAD gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NACAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005854 nascent polypeptide-associated complex IEA --
genes like me logo Genes that share ontologies with NACAD: view

Pathways & Interactions for NACAD Gene

SuperPathways for NACAD Gene

No Data Available

Gene Ontology (GO) - Biological Process for NACAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NACAD: view

No data available for Pathways by source and SIGNOR curated interactions for NACAD Gene

Transcripts for NACAD Gene

mRNA/cDNA for NACAD Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NACAD Gene

NAC alpha domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACAD Gene

No ASD Table

Relevant External Links for NACAD Gene

GeneLoc Exon Structure for
NACAD
ECgene alternative splicing isoforms for
NACAD

Expression for NACAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NACAD Gene

mRNA differential expression in normal tissues according to GTEx for NACAD Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.4) and Brain - Substantia nigra (x4.2).

Protein differential expression in normal tissues from HIPED for NACAD Gene

This gene is overexpressed in Fetal Brain (40.9) and Breast (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NACAD Gene



Protein tissue co-expression partners for NACAD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NACAD Gene:

NACAD

SOURCE GeneReport for Unigene cluster for NACAD Gene:

Hs.96633

Evidence on tissue expression from TISSUES for NACAD Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NACAD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NACAD Gene

Orthologs for NACAD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACAD 34 35
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia NACAD 34 35
  • 70.83 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 26 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nacad 35
  • 42 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NACA 35
  • 10 (a)
ManyToMany
chicken
(Gallus gallus)
Aves NACAD 35
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NACAD 35
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32173 34
zebrafish
(Danio rerio)
Actinopterygii nacad 35
  • 16 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nacalpha 35
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea icd-2 35
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD2 35
  • 37 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.765 34
rice
(Oryza sativa)
Liliopsida Os.9074 34
wheat
(Triticum aestivum)
Liliopsida Ta.13242 34
corn
(Zea mays)
Liliopsida Zm.2135 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1556 35
  • 64 (a)
OneToMany
Species where no ortholog for NACAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for NACAD Gene

ENSEMBL:
Gene Tree for NACAD (if available)
TreeFam:
Gene Tree for NACAD (if available)

Paralogs for NACAD Gene

Paralogs for NACAD Gene

(3) SIMAP similar genes for NACAD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NACAD: view

Variants for NACAD Gene

Sequence variations from dbSNP and Humsavar for NACAD Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000210695 -- 45,081,429(+) TTCTC(A/G)TGACA intron-variant, upstream-variant-2KB
rs1000339945 -- 45,082,299(+) GCGGC(C/T)CAGTC intron-variant, reference, missense
rs1000397875 -- 45,088,520(+) GCAGC(A/T)CGGTG intron-variant
rs1001304968 -- 45,087,665(+) GCCCT(G/T)AACCA intron-variant
rs1001377898 -- 45,083,216(+) GGGAC(C/T)GTAGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NACAD Gene

Variant ID Type Subtype PubMed ID
esv1076637 CNV deletion 17803354
nsv606846 CNV gain 21841781

Variation tolerance for NACAD Gene

Gene Damage Index Score: 8.23; 84.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NACAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NACAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NACAD Gene

Disorders for NACAD Gene

Relevant External Links for NACAD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NACAD

No disorders were found for NACAD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NACAD Gene

Publications for NACAD Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for NACAD Gene

Sources for NACAD Gene

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