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Aliases for NACAD Gene

Aliases for NACAD Gene

  • NAC Alpha Domain Containing 2 3
  • KIAA0363 4

External Ids for NACAD Gene

Summaries for NACAD Gene

GeneCards Summary for NACAD Gene

NACAD (NAC Alpha Domain Containing) is a Protein Coding gene. An important paralog of this gene is NACA2.

UniProtKB/Swiss-Prot for NACAD Gene

  • May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACAD Gene

Genomics for NACAD Gene

Genomic Location for NACAD Gene

Start:
45,080,437 bp from pter
End:
45,088,954 bp from pter
Size:
8,518 bases
Orientation:
Minus strand

Genomic View for NACAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NACAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACAD Gene

Regulatory Elements for NACAD Gene

Proteins for NACAD Gene

  • Protein details for NACAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15069-NACAD_HUMAN
    Recommended name:
    NAC-alpha domain-containing protein 1
    Protein Accession:
    O15069
    Secondary Accessions:

    Protein attributes for NACAD Gene

    Size:
    1562 amino acids
    Molecular mass:
    161101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NACAD Gene

Proteomics data for NACAD Gene at MOPED

Post-translational modifications for NACAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACAD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACAD Gene

Domains for NACAD Gene

Protein Domains for NACAD Gene

UniProtKB/Swiss-Prot:

NACAD_HUMAN
Domain:
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.:
    • O15069
Family:
  • Belongs to the NAC-alpha family.:
    • O15069
genes like me logo Genes that share domains with NACAD: view

No data available for Gene Families for NACAD Gene

Function for NACAD Gene

Molecular function for NACAD Gene

UniProtKB/Swiss-Prot Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

Phenotypes for NACAD Gene

GenomeRNAi human phenotypes for NACAD:
genes like me logo Genes that share phenotypes with NACAD: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NACAD Gene

Localization for NACAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACAD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NACAD Gene COMPARTMENTS Subcellular localization image for NACAD gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NACAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NACAD: view

Pathways for NACAD Gene

SuperPathways for NACAD Gene

No Data Available

Gene Ontology (GO) - Biological Process for NACAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NACAD: view

No data available for Pathways by source for NACAD Gene

Transcripts for NACAD Gene

mRNA/cDNA for NACAD Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NACAD Gene

NAC alpha domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACAD Gene

No ASD Table

Relevant External Links for NACAD Gene

GeneLoc Exon Structure for
NACAD
ECgene alternative splicing isoforms for
NACAD

Expression for NACAD Gene

mRNA expression in normal human tissues for NACAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NACAD Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.4) and Brain - Substantia nigra (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NACAD Gene

SOURCE GeneReport for Unigene cluster for NACAD Gene Hs.96633

genes like me logo Genes that share expressions with NACAD: view

Orthologs for NACAD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACAD 36
  • 98.31 (n)
  • 97.24 (a)
NACAD 37
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NACAD 36
  • 70.83 (n)
  • 62.01 (a)
NACAD 37
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NACA 37
  • 10 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Nacad 16
Nacad 37
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 26 (a)
OneToMany
-- 37
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves NACAD 37
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NACAD 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32173 36
zebrafish
(Danio rerio)
Actinopterygii nacad 37
  • 16 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nacalpha 37
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea icd-2 37
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD2 37
  • 37 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.765 36
corn
(Zea mays)
Liliopsida Zm.2135 36
rice
(Oryza sativa)
Liliopsida Os.9074 36
wheat
(Triticum aestivum)
Liliopsida Ta.13242 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1556 37
  • 64 (a)
OneToMany
Species with no ortholog for NACAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for NACAD Gene

ENSEMBL:
Gene Tree for NACAD (if available)
TreeFam:
Gene Tree for NACAD (if available)

Paralogs for NACAD Gene

Paralogs for NACAD Gene

Selected SIMAP similar genes for NACAD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NACAD: view

Variants for NACAD Gene

Sequence variations from dbSNP and Humsavar for NACAD Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2331207 -- 45,087,683(+) AAACT(C/T)GTCAC intron-variant
rs3735493 - 45,082,725(+) CTGGG(A/C)AGGAG reference, missense, intron-variant
rs3735494 - 45,084,687(+) TAGCC(A/G)CCTCC missense, reference
rs3735495 - 45,084,866(+) GTCCC(A/T)TCCTG missense, reference
rs4392784 -- 45,090,914(+) GTGTC(C/T)GCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NACAD Gene

Variant ID Type Subtype PubMed ID
nsv888001 CNV Loss 21882294
esv1076637 CNV Deletion 17803354

Relevant External Links for NACAD Gene

HapMap Linkage Disequilibrium report
NACAD

Disorders for NACAD Gene

No disorders were found for NACAD Gene.

No data available for UniProtKB/Swiss-Prot for NACAD Gene

Publications for NACAD Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for NACAD Gene

Sources for NACAD Gene

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