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NACAD Gene

protein-coding   GIFtS: 40

GC07M045067
NAC alpha domain containing
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for NACAD

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
KIAA0363 1, 2, 3
Descriptions
NAC alpha domain containing 2
External Ids
HGNC: 221961
Entrez Gene: 231482
UniProtKB: O150693
Ensembl: ENSG000001362747
Search outside databases for aliases for NACAD gene

Previous GC identifer: GC07M045087

Summaries
for NACAD

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069
Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic
reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block
their interaction with the signal recognition particle (SRP), which normally targets nascent
secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein
translocation sites in the ER membrane (M sites) (By similarity)

Genomic Location
for NACAD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

NACAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M045067:     (about GC identifiers)

Start:
 45,067,578 bp from pter
End:
 45,095,757 bp from pter
Size:
 28,180 bases
Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 45,140,529-45,168,402     
RefSeq DNA sequence:
NT_079592.2  NC_000007.12  NT_007819.16  

Proteins
for NACAD

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069 (See protein sequence)
Recommended Name: NAC-alpha domain-containing protein 1  
Size: 1562 amino acids; 161117 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001139806.1  

    ENSEMBL proteins: 
    ENSP00000258775 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for NACAD: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for NACAD

    Assays for NACAD: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for NACAD

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR002715 Nas_poly-pep-assoc_cplx


       GeneDecks  NACAD for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15069

    ProtoNet protein and cluster: O15069

    UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069
    Similarity: Belongs to the NAC-alpha family
    Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain

    Gene Function
    for NACAD

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for NACAD

                  Sigma-Aldrich siRNA for NACAD  
                         Sigma-Aldrich shRNA for NACAD  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                    Browse Origene genome-wide validated SYBR primer pairs

    UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069
    Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic
    reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block
    their interaction with the signal recognition particle (SRP), which normally targets nascent
    secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein
    translocation sites in the ER membrane (M sites) (By similarity)

    Pathways & Interactions
    for NACAD

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for NACAD (ENSP000002587753) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF331ENSP000002531443STRING (score=.724)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031 protein transport IEA--
    About this table

    Drugs & Compounds
    for NACAD

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NACAD

    Transcripts
    for NACAD

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Sigma-Aldrich siRNA for NACAD  
                         Sigma-Aldrich shRNA for NACAD  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    XM_166571  

    REFSEQ mRNAs for NACAD gene: 

    NM_001146334.1   


                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Additional cDNA sequence: 

    AB002361.1 XM_166571.6 

    3 DOTS entries:

    DT.109423  DT.100658926  DT.97787649 

    24/64 AceView cDNA sequences (see all 64 ):

    BM723495 BM728120 BE645604 BM680676 BM727592 CD675048 BM681033 AB002361 
    AA297699 BF528737 AL119753 AW206432 BP431048 BU855107 BM714727 AV726228 
    BU682625 BU859196 BM313707 BM669143 BG913099 BM047267 AW025351 BM696401 

    Unigene Cluster for NACAD:

    NAC alpha domain containing
    Hs.96633  [show with all ESTs]
    Unigene Representative Sequence: XM_166571


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000258775  

    Expression
    for NACAD

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NACAD expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NACAD

    1 / 2

    3 probe-sets matching NACAD gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41055_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --

    		213630_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		213630_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  NACAD for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TAGCCACTGA

    SOURCE GeneReport for Unigene cluster: Hs.96633

    Orthologs
    for NACAD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for NACAD gene from 5/14 species (see all 14 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 NACAD1   -- NAC alpha domain containing 85.03(n)
    80.29(a)    		 463390  XM_519080.2  XP_519080.2 
    cow
    (Bos taurus)    		 NACAD1   -- NAC alpha domain containing 56.95(n)
    44.03(a)    		 531208  XM_609695.3  XP_609695.3 
    rat
    (Rattus norvegicus)    		 Nacad1   -- NAC alpha domain containing 65.38(n)
    54.38(a)    		 289786  XM_214092.4  XP_214092.3 
    mouse
    (Mus musculus)    		 Nacad5
    AB1822831    		 115
    		 NAC alpha domain containing5
    cDNA sequence AB1822831    		 68.17(n)1
    58.23(a)1    		 1929501  NM_001081652.11  NP_001075121.11 
     AB1822835  AI4297385  (see all 8)
    chicken
    (Gallus gallus)    		 NACAD1   -- NAC alpha domain containing 47.69(n)
    36.08(a)    		 420409  XM_418516.2  XP_418516.2 
    About this table        Species with no ortholog for NACAD

    ENSEMBL Gene Tree for NACAD

    Paralogs
    for NACAD

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for NACAD gene
    NACA3P2  NACA22  NACA2  

    SNPs/Variants
    for NACAD

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/66 NCBI SNPs in NACAD are shown (see all 66 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 54)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs37354931,2
    		A,C,F,H45088849(+) CTGGGC/AAGGAG 1 F/C mis1 ese35Minor allele frequency- A:0.08EA EU WA 1900
    rs37354941,2
    		A,C,F,H45090811(+) TAGCCA/GCCTCC 1 V/A mis1 ese310Minor allele frequency- G:0.27EU EA WA NA 1016
    rs37354951,2
    		A,C,F,H45090990(+) GTCCCA/TTCCTG 1 D/E mis19Minor allele frequency- T:0.23EA EU WA 2314
    rs77778351,2
    		A,C,F,H45090533(+) CTCTTC/TAGCCT 1 K/E mis1 ese34Minor allele frequency- T:0.46EU EA WA 412
    rs102431851,2
    		A,C,F45088989(+) GGCGCA/CTCGGG 1 D/E mis1 ese34Minor allele frequency- C:0.38NA EA 362
    --
    rs77908441,2
    		A,C,H45090382(+) TCATAG/ACGGAG 1 A/V mis14Minor allele frequency- A:0.00EU EA WA 418
    --
    rs102768741,2
    		A,C45089710(+) ACACAA/GGCGTG 1 P/L mis1 ese30--------
    --
    rs102767481,2
    		A,C45089615(+) CTTTGA/GGGCTG 1 P/S mis1 ese30--------
    --
    rs97917401,2
    		A,C45096553(+) atcgcA/Gccact 1 -- ng310--------
    --
    rs69602851,2
    		A,C45095703(+) AGGCGA/GCCCGG 1 S/P mis10--------
    About this table

    HapMap Linkage Disequilibrium images for NACAD (up to first 250kb)

    Disorders & Mutations
    for NACAD

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for NACAD

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for NACAD

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		3 PubMed articles for NACAD gene:

    Search for NACAD

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NACAD

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 23148 HGNC: 22196 AceView: KIAA0363 Ensembl:ENSG00000136274 euGenes: HUgn23148
    ECgene: NACAD H-InvDB: NACAD

    Other Databases showing NACAD

    (According to HUGE)
    About This Section
    HUGE: KIAA0363

    Specialized Databases showing NACAD

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for NACAD

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for NACAD

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NACAD:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NACAD-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NACAD Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NACAD Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search Tocris compounds for NACAD




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for NACAD

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