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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NACAD Gene

protein-coding GIFtS: 43
GCID: GC07M045120

NAC alpha domain containing

Explore 1 disease affiliated with
NACAD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NAC Alpha Domain Containing¹ ²
KIAA0363¹ ³
NAC-Alpha Domain-Containing Protein 1²

External Ids:	HGNC: 22196¹	Entrez Gene: 23148²	Ensembl: ENSG00000136274⁷	UniProtKB: O15069³

Export aliases for NACAD gene to outside databases

Previous GC identifers: GC07M045087 GC07M045067 GC07M045004

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069

Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind

to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition

particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of

ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NACAD gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 NF-kappaB HEN1 PPAR-gamma1 E2F-1 E2F PPAR-gamma2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NACAD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NACAD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13

NACAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACAD gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M045120: view genomic region (about GC identifiers)

Start:	45,120,036 bp from pter	End:	45,128,513 bp from pter
Size:	8,478 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 45,159,326-45,167,663

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069 (See protein sequence)

Recommended Name: NAC-alpha domain-containing protein 1

Size: 1562 amino acids; 161101 Da

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for NACAD: NX_O15069

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15069

NACAD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001139806.1

ENSEMBL proteins:

ENSP00000420477

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

NACAD for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NACAD for domains About GeneDecksing

2 InterPro domains/families:

IPR016641 EGD2/NACA

IPR002715 Nas_poly-pep-assoc_cplx_dom

Graphical View of Domain Structure for InterPro Entry O15069

ProtoNet protein and cluster: O15069

UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069

Similarity: Belongs to the NAC-alpha family

Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NACAD_HUMAN, O15069

Function: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind

to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition

particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of

ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)

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In Situ Assay
Products:

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1 GenomeRNAi human phenotype for NACAD:

Decreased cell number and incr

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NACAD

5/8 Interacting proteins for NACAD (O15069^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBLC	Q9ULV8²^,³	MINT-8250690 I2D: score=2
HDAC6	Q9UBN7²^,³	MINT-8258054 I2D: score=2
MAP4K2	Q12851²^,³	MINT-8260438 I2D: score=2
NR4A1	P22736²^,³	MINT-8264072 I2D: score=2
PTK2	Q05397²^,³	MINT-8267605 I2D: score=2

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--

NACAD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NACAD
Search CenterWatch for drugs/clinical trials and news about NACAD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NACAD gene:

NM_001146334.1

Unigene Cluster for NACAD:

NAC alpha domain containing

Hs.96633 [show with all ESTs]

Unigene Representative Sequence: NM_001146334

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000490531(uc003tmt.3) ENST00000460409

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Additional cDNA sequence: AB002361.1

3 DOTS entries:

DT.109423 DT.100658926 DT.97787649

24/64 AceView cDNA sequences (see all 64):

BM728120 BM727592 BE645604 BF528737 BM681033 CD675048 BM723495 AB002361

AL119753 BM680676 AA297699 BQ614463 BM669143 AW519100 AW025351 BM700205

BX411309 BM047267 AV726228 BM313976 BM048833 BM714727 BU543827 BU855107

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NACAD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCCACTGA

About this image

NACAD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Bone

Eye

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NACAD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NACAD

SOURCE GeneReport for Unigene cluster: Hs.96633

SABiosciences Custom PCR Arrays for NACAD

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACAD gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NACAD¹	NAC alpha domain containing	47.42(n) 36.15(a)		420409 XM_418516.3 XP_418516.3
lizard (Anolis carolinensis)	Reptilia	NACAD⁶	--	66(a)	1 ↔ 1	AAWZ02040392(2124-3349)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32173²	Xenopus laevis transcribed sequence with moderate similarity more	82.68(n)		BJ641912.1
zebrafish (Danio rerio)	Actinopterygii	nacad⁶	NAC alpha domain containing	17(a)	1 ↔ 1	16(29852634-29869234)
fruit fly (Drosophila melanogaster)	Insecta	Nacalpha⁶ CG4415⁶	--	51(a) 21(a)	1 ↔ many possible ortholog	2R(8647198-8648377) 2L(1037246-1038685)
worm (Caenorhabditis elegans)	Secernentea	Y65B4BR.5⁶	Nascent polypeptide-associated complex subunit alp...	47(a)	1 → many	I(535792-536673)
thale cress (Arabidopsis thaliana)	eudicotyledons	NACA3⁶ AT3G12390⁶ (see all 5)	Nascent polypeptide-associated complex subunit alp... Nascent polypeptide-associated complex subunit alp... (see all 5)	49(a) 49(a) (see all 5)	many ↔ many many ↔ many (see all 5)	5(4471277-4472855) 3(3942257-3943809)
rice (Oryza sativa)	Liliopsida	Os.9074²	Oryza sativa (japonica cultivar-group) isolate 20527 more	77.36(n)		AK099300.1

ENSEMBL Gene Tree for NACAD (if available)
TreeFam Gene Tree for NACAD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NACAD gene

NACA² NACA2²

3 SIMAP similar genes for NACAD using alignment to 1 protein entry: NACAD_HUMAN:

NACA NACAP1 NACA2

NACAD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73694277^1,2	C,	--	45119592(+)	`CCAGAG/TGGTGG`	2	--	int¹ nc-transcript-variant		1		WA	2
rs73694278^1,2	C,	--	45119609(+)	`TACACG/CGGGGA`	2	--	nc-transcript-variantint¹		1		WA	2
rs188799297^1,2		--	45119712(+)	`GTGACA/GCCAGA`	2	--	nc-transcript-variantint¹		0	--	--	--	--
rs201552819^1,2		--	45119776(+)	`GACAC-/GAGGGT`	2	--	int¹ us2k¹		0	--	--	--	--
rs140390338^1,2	C,	--	45119806(+)	`GTGAT-/GAGGGGAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs200625599^1,2		--	45119833(+)	`AGGGG-/ACACAAG`	2	--	int¹ us2k¹		0	--	--	--	--
rs34537782^1,2	C,	--	45119837(+)	`GACAC-/AAGAGGG`	2	--	us2k¹ int¹		1		CSA	2
rs138296546^1,2	C,	--	45119873(+)	`TGAGG-/GGGC ACCAGAGGGCA`	2	--	us2k¹ int¹		0	--	--	--	--
rs202236700^1,2	C	--	45119882(-)	`TGCCCC/TCTGGT`	2	--	us2k¹ int¹		0	--	--	--	--
rs35199312^1,2	C,F,	--	45119946(+)	`CCAGAT/GGGTGG`	2	--	us2k¹ int¹		7		NA WA CSA EA	365

HapMap Linkage Disequilibrium report for NACAD (45120036 - 45128513 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NACAD
1 Indel: 28649

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for NACAD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NACAD for disorders About GeneDecksing

1 disease for NACAD: About MalaCards

malaria

Export disorders for NACAD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NACAD gene integrated from 9 sources:
(articles sorted by number of sources associating them with NACAD)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (1997)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23148	HGNC: 22196	AceView: KIAA0363	Ensembl:ENSG00000136274	euGenes: HUgn23148
ECgene: NACAD	H-InvDB: NACAD

(According to HUGE)
About This Section

HUGE: KIAA0363

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NACAD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NACAD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NACAD gene:
Search GeneIP for patents involving NACAD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NACAD Gene

NAC alpha domain containing

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NACAD Gene

NAC alpha domain containing

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