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Aliases for NACA2 Gene

Aliases for NACA2 Gene

  • Nascent Polypeptide-Associated Complex Alpha Subunit 2 2 3
  • Alpha-NAC Protein 2 3
  • NACAL 3 4
  • Nascent-Polypeptide-Associated Complex Alpha Polypeptide-Like 2
  • IgE Autoantigen Alpha-Nascent Polypeptide-Associated Complex 3
  • Nascent Polypeptide-Associated Complex, Alpha Polypeptide, 2 3
  • Nascent Polypeptide-Associated Complex Subunit Alpha-Like 4
  • Nascent Polypeptide-Associated Complex Subunit Alpha-2 3
  • Hom S 2.01 Protein 3
  • Alpha-NAC-Like 4
  • NAC-Alpha-Like 4
  • Hom S 2.01 4
  • ANAC 3

External Ids for NACA2 Gene

Previous Symbols for NACA2 Gene

  • NACAL

Summaries for NACA2 Gene

GeneCards Summary for NACA2 Gene

NACA2 (Nascent Polypeptide-Associated Complex Alpha Subunit 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity and TBP-class protein binding. An important paralog of this gene is NACA.

UniProtKB/Swiss-Prot for NACA2 Gene

  • Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACA2 Gene

Genomics for NACA2 Gene

Genomic Location for NACA2 Gene

Start:
61,590,426 bp from pter
End:
61,591,202 bp from pter
Size:
777 bases
Orientation:
Minus strand

Genomic View for NACA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NACA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACA2 Gene

Regulatory Elements for NACA2 Gene

Proteins for NACA2 Gene

  • Protein details for NACA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H009-NACA2_HUMAN
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha-2
    Protein Accession:
    Q9H009
    Secondary Accessions:
    • Q2VIR9

    Protein attributes for NACA2 Gene

    Size:
    215 amino acids
    Molecular mass:
    23223 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity).
    Miscellaneous:
    • NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA

neXtProt entry for NACA2 Gene

Proteomics data for NACA2 Gene at MOPED

Post-translational modifications for NACA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACA2 Gene

Domains for NACA2 Gene

Protein Domains for NACA2 Gene

UniProtKB/Swiss-Prot:

NACA2_HUMAN
Domain:
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.:
    • Q9H009
  • Contains 1 UBA domain.:
    • Q9H009
Family:
  • Belongs to the NAC-alpha family.:
    • Q9H009
genes like me logo Genes that share domains with NACA2: view

No data available for Gene Families for NACA2 Gene

Function for NACA2 Gene

Molecular function for NACA2 Gene

UniProtKB/Swiss-Prot Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

Gene Ontology (GO) - Molecular Function for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NACA2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NACA2 Gene

Localization for NACA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACA2 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NACA2: view

Pathways for NACA2 Gene

SuperPathways for NACA2 Gene

No Data Available

Interacting Proteins for NACA2 Gene

Gene Ontology (GO) - Biological Process for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NACA2: view

No data available for Pathways by source for NACA2 Gene

Transcripts for NACA2 Gene

mRNA/cDNA for NACA2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NACA2 Gene

Nascent polypeptide-associated complex alpha subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACA2 Gene

No ASD Table

Relevant External Links for NACA2 Gene

GeneLoc Exon Structure for
NACA2
ECgene alternative splicing isoforms for
NACA2

Expression for NACA2 Gene

mRNA expression in normal human tissues for NACA2 Gene

mRNA differential expression in normal tissues according to GTEx for NACA2 Gene

This gene is overexpressed in Testis (45.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NACA2 Gene

SOURCE GeneReport for Unigene cluster for NACA2 Gene Hs.591178

mRNA Expression by UniProt/SwissProt for NACA2 Gene

Q9H009-NACA2_HUMAN
Tissue specificity: Expressed specifically in testis and skeletal muscle.
genes like me logo Genes that share expressions with NACA2: view

Orthologs for NACA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACA2 36
  • 98.91 (n)
  • 97.21 (a)
NACA2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NACA 37
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Naca 37
  • 8 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 24 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 12 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naca.2 36
  • 76.95 (n)
  • 88.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nacalpha 37
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea icd-2 37
  • 51 (a)
OneToMany
Y65B4BR.5 36
  • 59.26 (n)
  • 62.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD2 37
  • 33 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os01g0698900 36
  • 59.18 (n)
  • 59.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1556 37
  • 71 (a)
OneToMany
Species with no ortholog for NACA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NACA2 Gene

ENSEMBL:
Gene Tree for NACA2 (if available)
TreeFam:
Gene Tree for NACA2 (if available)

Paralogs for NACA2 Gene

Paralogs for NACA2 Gene

Selected SIMAP similar genes for NACA2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NACA2 Gene

genes like me logo Genes that share paralogs with NACA2: view

Variants for NACA2 Gene

Sequence variations from dbSNP and Humsavar for NACA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2188729 -- 61,591,773(-) TTAAA(C/T)TGAAT upstream-variant-2KB
rs4141531 -- 61,591,716(-) AGATC(A/G)AGGGA upstream-variant-2KB
rs7219527 -- 61,592,528(+) TTTGG(C/T)AGCAC upstream-variant-2KB
rs17531723 - 61,590,991(+) ACCGA(C/T)TGGTT missense, reference
rs17610181 -- 61,590,592(+) AGCTC(A/G)GACTG reference, stop-gained

Relevant External Links for NACA2 Gene

HapMap Linkage Disequilibrium report
NACA2

No data available for Structural Variations from Database of Genomic Variants (DGV) for NACA2 Gene

Disorders for NACA2 Gene

Relevant External Links for NACA2

Genetic Association Database (GAD)
NACA2
Human Genome Epidemiology (HuGE) Navigator
NACA2
genes like me logo Genes that share disorders with NACA2: view

No data available for UniProtKB/Swiss-Prot for NACA2 Gene

Publications for NACA2 Gene

  1. Characterization of a novel isoform of alpha-nascent polypeptide- associated complex as IgE-defined autoantigen. (PMID: 12406326) Mossabeb R. … Valenta R. (J. Invest. Dermatol. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 49
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 49

Products for NACA2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate NACA2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NACA2
    • Block miRNA regulation of NACA2 using miScript Target Protectors

    Sources for NACA2 Gene

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