Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NACA2 Gene

Aliases for NACA2 Gene

  • Nascent Polypeptide Associated Complex Alpha Subunit 2 2 3
  • Nascent Polypeptide-Associated Complex Alpha Subunit 2 2 3 5
  • Alpha-NAC Protein 2 3
  • NACAL 3 4
  • Nascent-Polypeptide-Associated Complex Alpha Polypeptide-Like 2
  • IgE Autoantigen Alpha-Nascent Polypeptide-Associated Complex 3
  • Nascent Polypeptide-Associated Complex, Alpha Polypeptide, 2 3
  • Nascent Polypeptide-Associated Complex Subunit Alpha-Like 4
  • Hom S 2.01 Protein 3
  • Alpha-NAC-Like 4
  • NAC-Alpha-Like 4
  • Hom S 2.01 4
  • ANAC 3

External Ids for NACA2 Gene

Previous HGNC Symbols for NACA2 Gene

  • NACAL

Previous GeneCards Identifiers for NACA2 Gene

  • GC17M057025
  • GC17M059668
  • GC17M055034

Summaries for NACA2 Gene

GeneCards Summary for NACA2 Gene

NACA2 (Nascent Polypeptide Associated Complex Alpha Subunit 2) is a Protein Coding gene. An important paralog of this gene is NACA.

UniProtKB/Swiss-Prot for NACA2 Gene

  • Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACA2 Gene

Genomics for NACA2 Gene

Regulatory Elements for NACA2 Gene

Enhancers for NACA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NACA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NACA2 Gene

Chromosome:
17
Start:
61,590,426 bp from pter
End:
61,591,202 bp from pter
Size:
777 bases
Orientation:
Minus strand

Genomic View for NACA2 Gene

Genes around NACA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACA2 Gene

Proteins for NACA2 Gene

  • Protein details for NACA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H009-NACA2_HUMAN
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha-2
    Protein Accession:
    Q9H009
    Secondary Accessions:
    • Q2VIR9

    Protein attributes for NACA2 Gene

    Size:
    215 amino acids
    Molecular mass:
    23223 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity).
    Miscellaneous:
    • NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

neXtProt entry for NACA2 Gene

Proteomics data for NACA2 Gene at MOPED

Post-translational modifications for NACA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACA2 Gene

Domains & Families for NACA2 Gene

Protein Domains for NACA2 Gene

Suggested Antigen Peptide Sequences for NACA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H009

UniProtKB/Swiss-Prot:

NACA2_HUMAN :
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.
  • Belongs to the NAC-alpha family.
Domain:
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the NAC-alpha family.
genes like me logo Genes that share domains with NACA2: view

No data available for Gene Families for NACA2 Gene

Function for NACA2 Gene

Molecular function for NACA2 Gene

UniProtKB/Swiss-Prot Function:
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
genes like me logo Genes that share phenotypes with NACA2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NACA2 Gene

Localization for NACA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACA2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NACA2 Gene COMPARTMENTS Subcellular localization image for NACA2 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NACA2 Gene

Pathways & Interactions for NACA2 Gene

SuperPathways for NACA2 Gene

No Data Available

Interacting Proteins for NACA2 Gene

Gene Ontology (GO) - Biological Process for NACA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NACA2 Gene

Drugs & Compounds for NACA2 Gene

No Compound Related Data Available

Transcripts for NACA2 Gene

mRNA/cDNA for NACA2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NACA2 Gene

Nascent polypeptide-associated complex alpha subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACA2 Gene

No ASD Table

Relevant External Links for NACA2 Gene

GeneLoc Exon Structure for
NACA2
ECgene alternative splicing isoforms for
NACA2

Expression for NACA2 Gene

mRNA expression in normal human tissues for NACA2 Gene

mRNA differential expression in normal tissues according to GTEx for NACA2 Gene

This gene is overexpressed in Testis (x45.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NACA2 Gene



SOURCE GeneReport for Unigene cluster for NACA2 Gene Hs.591178

mRNA Expression by UniProt/SwissProt for NACA2 Gene

Q9H009-NACA2_HUMAN
Tissue specificity: Expressed specifically in testis and skeletal muscle.
genes like me logo Genes that share expression patterns with NACA2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for NACA2 Gene

Orthologs for NACA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACA2 35
  • 98.91 (n)
  • 97.21 (a)
NACA2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NACA 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Naca 36
  • 8 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naca.2 35
  • 76.95 (n)
  • 88.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nacalpha 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y65B4BR.5 35
  • 59.26 (n)
  • 62.5 (a)
icd-2 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD2 36
  • 33 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os01g0698900 35
  • 59.18 (n)
  • 59.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1556 36
  • 71 (a)
OneToMany
Species with no ortholog for NACA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NACA2 Gene

ENSEMBL:
Gene Tree for NACA2 (if available)
TreeFam:
Gene Tree for NACA2 (if available)

Paralogs for NACA2 Gene

Paralogs for NACA2 Gene

(3) SIMAP similar genes for NACA2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NACA2 Gene

genes like me logo Genes that share paralogs with NACA2: view

Variants for NACA2 Gene

Sequence variations from dbSNP and Humsavar for NACA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17531723 - 61,590,991(+) ACCGA(C/T)TGGTT reference, missense
rs2188729 -- 61,591,773(-) TTAAA(C/T)TGAAT upstream-variant-2KB
rs4141531 -- 61,591,716(-) AGATC(A/G)AGGGA upstream-variant-2KB
rs7219527 -- 61,592,528(+) TTTGG(C/T)AGCAC upstream-variant-2KB
rs17610181 -- 61,590,592(+) AGCTC(A/G)GACTG reference, stop-gained

Variation tolerance for NACA2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.72; 96.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NACA2 Gene

HapMap Linkage Disequilibrium report
NACA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NACA2 Gene

Disorders for NACA2 Gene

Relevant External Links for NACA2

Genetic Association Database (GAD)
NACA2
Human Genome Epidemiology (HuGE) Navigator
NACA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NACA2

No disorders were found for NACA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NACA2 Gene

Publications for NACA2 Gene

  1. Characterization of a novel isoform of alpha-nascent polypeptide- associated complex as IgE-defined autoantigen. (PMID: 12406326) Mossabeb R. … Valenta R. (J. Invest. Dermatol. 2002) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. The human skin-associated autoantigen I+-NAC activates monocytes and dendritic cells via TLR-2 and primes an IL-12-dependent Th1 response. (PMID: 23657466) Hradetzky S. … Werfel T. (J. Invest. Dermatol. 2013) 3
  4. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. (PMID: 23989986) Evangelou E. … Valdes A.M. (Ann. Rheum. Dis. 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for NACA2 Gene

Sources for NACA2 Gene

Content