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Aliases for NACA2 Gene

Aliases for NACA2 Gene

  • Nascent Polypeptide Associated Complex Alpha Subunit 2 2 3 5
  • Alpha-NAC Protein 2 3
  • NACAL 3 4
  • Nascent-Polypeptide-Associated Complex Alpha Polypeptide-Like 2
  • IgE Autoantigen Alpha-Nascent Polypeptide-Associated Complex 3
  • Nascent Polypeptide-Associated Complex, Alpha Polypeptide, 2 3
  • Nascent Polypeptide-Associated Complex Subunit Alpha-Like 4
  • Nascent Polypeptide-Associated Complex Alpha Subunit 2 2
  • Nascent Polypeptide-Associated Complex Subunit Alpha-2 3
  • Hom S 2.01 Protein 3
  • Alpha-NAC-Like 4
  • NAC-Alpha-Like 4
  • Hom S 2.01 4
  • ANAC 3

External Ids for NACA2 Gene

Previous HGNC Symbols for NACA2 Gene

  • NACAL

Previous GeneCards Identifiers for NACA2 Gene

  • GC17M057025
  • GC17M059668
  • GC17M055034

Summaries for NACA2 Gene

GeneCards Summary for NACA2 Gene

NACA2 (Nascent Polypeptide Associated Complex Alpha Subunit 2) is a Protein Coding gene. An important paralog of this gene is NACA.

UniProtKB/Swiss-Prot for NACA2 Gene

  • Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACA2 Gene

Genomics for NACA2 Gene

Regulatory Elements for NACA2 Gene

Enhancers for NACA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G061334 1.6 Ensembl ENCODE dbSUPER 10.5 +255.4 255438 2.3 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 FOS NACA2 GC17P061333 ENSG00000273982
GH17G061567 1.2 ENCODE dbSUPER 12.3 +22.2 22157 3.9 FOXA2 ATF1 SLC30A9 ZNF121 FOS SP5 PPARG KAT8 MIER3 RCOR2 NACA2 C17orf82 TBX4 TBX2 ENSG00000267137
GH17G060598 1.5 FANTOM5 ENCODE 9.8 +990.3 990322 4.9 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPM1D RPS6KB1 ENSG00000266934 C17orf82 NACA2 GC17M060663 RNU6-623P
GH17G062470 1.5 Ensembl ENCODE dbSUPER 9.8 -879.9 -879899 1.0 PKNOX1 SIN3A FEZF1 ZNF48 TCF12 ZNF121 GLIS2 ELK1 ZNF207 FOS INTS2 NACA2 TLK2 RPS10P26
GH17G061337 1.5 Ensembl ENCODE dbSUPER 9.1 +252.8 252800 2.4 PKNOX1 SIN3A FEZF1 ZNF121 KLF7 FOS TSHZ1 PPARG MEF2D ZNF579 NACA2 GC17P061333 ENSG00000273982
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NACA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NACA2 Gene

Chromosome:
17
Start:
61,590,426 bp from pter
End:
61,591,202 bp from pter
Size:
777 bases
Orientation:
Minus strand

Genomic View for NACA2 Gene

Genes around NACA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NACA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NACA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACA2 Gene

Proteins for NACA2 Gene

  • Protein details for NACA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H009-NACA2_HUMAN
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha-2
    Protein Accession:
    Q9H009
    Secondary Accessions:
    • Q2VIR9

    Protein attributes for NACA2 Gene

    Size:
    215 amino acids
    Molecular mass:
    23223 Da
    Quaternary structure:
    • Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity).
    Miscellaneous:
    • NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

neXtProt entry for NACA2 Gene

Post-translational modifications for NACA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NACA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NACA2 Gene

Domains & Families for NACA2 Gene

Protein Domains for NACA2 Gene

Suggested Antigen Peptide Sequences for NACA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H009

UniProtKB/Swiss-Prot:

NACA2_HUMAN :
  • Belongs to the NAC-alpha family.
Family:
  • Belongs to the NAC-alpha family.
genes like me logo Genes that share domains with NACA2: view

No data available for Gene Families for NACA2 Gene

Function for NACA2 Gene

Molecular function for NACA2 Gene

UniProtKB/Swiss-Prot Function:
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
genes like me logo Genes that share phenotypes with NACA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NACA2 Gene

Localization for NACA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACA2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NACA2 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005854 nascent polypeptide-associated complex IEA --
genes like me logo Genes that share ontologies with NACA2: view

Pathways & Interactions for NACA2 Gene

SuperPathways for NACA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NACA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NACA2: view

No data available for Pathways by source and SIGNOR curated interactions for NACA2 Gene

Drugs & Compounds for NACA2 Gene

No Compound Related Data Available

Transcripts for NACA2 Gene

mRNA/cDNA for NACA2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NACA2 Gene

Nascent polypeptide-associated complex alpha subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NACA2 Gene

No ASD Table

Relevant External Links for NACA2 Gene

GeneLoc Exon Structure for
NACA2
ECgene alternative splicing isoforms for
NACA2

Expression for NACA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NACA2 Gene

mRNA differential expression in normal tissues according to GTEx for NACA2 Gene

This gene is overexpressed in Testis (x45.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NACA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NACA2 Gene:

NACA2

SOURCE GeneReport for Unigene cluster for NACA2 Gene:

Hs.591178

mRNA Expression by UniProt/SwissProt for NACA2 Gene:

Q9H009-NACA2_HUMAN
Tissue specificity: Expressed specifically in testis and skeletal muscle.
genes like me logo Genes that share expression patterns with NACA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NACA2 Gene

Orthologs for NACA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NACA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NACA2 34 35
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia NACA 35
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 24 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 12 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Naca 35
  • 8 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naca.2 34
  • 76.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nacalpha 35
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y65B4BR.5 34
  • 59.26 (n)
icd-2 35
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD2 35
  • 33 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os01g0698900 34
  • 59.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1556 35
  • 71 (a)
OneToMany
Species where no ortholog for NACA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NACA2 Gene

ENSEMBL:
Gene Tree for NACA2 (if available)
TreeFam:
Gene Tree for NACA2 (if available)

Paralogs for NACA2 Gene

Paralogs for NACA2 Gene

(3) SIMAP similar genes for NACA2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NACA2 Gene

genes like me logo Genes that share paralogs with NACA2: view

Variants for NACA2 Gene

Sequence variations from dbSNP and Humsavar for NACA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000383930 -- 61,591,115(+) CCTGT(C/T)TCAGC reference, synonymous-codon
rs1002817552 -- 61,592,696(+) ATCAC(C/T)AAAGA upstream-variant-2KB
rs1003538931 -- 61,591,584(+) CGGTT(G/T)TCTCA upstream-variant-2KB
rs1003847190 -- 61,591,283(+) AAAAA(A/C/G)ACATT upstream-variant-2KB
rs1003918306 -- 61,590,797(+) TCTTG(C/G)ATCTT reference, missense

Variation tolerance for NACA2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.72; 96.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NACA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NACA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NACA2 Gene

Disorders for NACA2 Gene

Relevant External Links for NACA2

Genetic Association Database (GAD)
NACA2
Human Genome Epidemiology (HuGE) Navigator
NACA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NACA2

No disorders were found for NACA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NACA2 Gene

Publications for NACA2 Gene

  1. Characterization of a novel isoform of alpha-nascent polypeptide- associated complex as IgE-defined autoantigen. (PMID: 12406326) Mossabeb R. … Valenta R. (J. Invest. Dermatol. 2002) 2 3 4 64
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  4. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NACA2 Gene

Sources for NACA2 Gene

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