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Aliases for NACA Gene

Aliases for NACA Gene

  • Nascent Polypeptide-Associated Complex Alpha Subunit 2 3
  • Nascent-Polypeptide-Associated Complex Alpha Polypeptide 2 3
  • Alpha-NAC, Muscle-Specific Form 3 4
  • NAC-Alpha 3 4
  • SkNAC 3 4
  • Nascent Polypeptide-Associated Complex Subunit Alpha 3
  • Allergen Hom S 2 4
  • Alpha-NAC 4
  • HSD48 3
  • NACA1 3

External Ids for NACA Gene

Summaries for NACA Gene

Entrez Gene Summary for NACA Gene

  • The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NACA Gene

NACA (Nascent Polypeptide-Associated Complex Alpha Subunit) is a Protein Coding gene. Diseases associated with NACA include lethal midline granuloma and atopic dermatitis. Among its related pathways are ERK Signaling. GO annotations related to this gene include transcription coactivator activity and TBP-class protein binding. An important paralog of this gene is NACA2.

UniProtKB/Swiss-Prot for NACA Gene

  • Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).

  • Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Gene Wiki entry for NACA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NACA Gene

Genomics for NACA Gene

Genomic Location for NACA Gene

Start:
56,712,427 bp from pter
End:
56,731,628 bp from pter
Size:
19,202 bases
Orientation:
Minus strand

Genomic View for NACA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NACA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NACA Gene

Regulatory Elements for NACA Gene

Proteins for NACA Gene

  • Protein details for NACA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PAV3-NACAM_HUMAN
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha, muscle-specific form
    Protein Accession:
    E9PAV3
    Secondary Accessions:

    Protein attributes for NACA Gene

    Size:
    2078 amino acids
    Molecular mass:
    205422 Da
    Quaternary structure:
    • Interacts (via PXLXP motif) with the muscle-restricted histone methyltransferase SMYD1 (via MYND-type zinc finger).

    Alternative splice isoforms for NACA Gene

    UniProtKB/Swiss-Prot:
  • Protein details for NACA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13765-NACA_HUMAN
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha
    Protein Accession:
    Q13765
    Secondary Accessions:
    • A8MTN7
    • B2R4P8
    • F8VU71
    • Q3KQV4
    • Q53A18
    • Q53G46

    Protein attributes for NACA Gene

    Size:
    215 amino acids
    Molecular mass:
    23384 Da
    Quaternary structure:
    • Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit and contacts the ribosomal protein L23, which is positioned near the exiting site. Both subunits can contact nascent polypeptide chains. NACA may also form homodimers, and only this form binds DNA. Interacts with ASFV protein H339R.
    SequenceCaution:
    • Sequence=AAV83778.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NACA Gene

    Alternative splice isoforms for NACA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NACA Gene

Proteomics data for NACA Gene at MOPED

Post-translational modifications for NACA Gene

  • Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt
  • Ubiquitination at Lys100 and Lys142

No data available for DME Specific Peptides for NACA Gene

Domains for NACA Gene

Protein Domains for NACA Gene

UniProtKB/Swiss-Prot:

NACA_HUMAN
Domain:
  • The proline-rich muscle-specific exon 3 contains eighteen approximate 23-AA repeats:
    • E9PAV3
  • Contains 1 NAC-A/B (NAC-alpha/beta) domain.:
    • E9PAV3
    • Q13765
  • Contains 1 UBA domain.:
    • E9PAV3
  • The positively charged inner surface of the NAC-A/B domain is crucial for NACA localization in the nucleus and DNA-binding. This region is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit, it also displays much higher affinity for RNA than DNA:
    • Q13765
  • Contains 1 UBA domain.:
    • Q13765
Family:
  • Belongs to the NAC-alpha family.:
    • Q13765
genes like me logo Genes that share domains with NACA: view

No data available for Gene Families for NACA Gene

Function for NACA Gene

Molecular function for NACA Gene

GENATLAS Biochemistry: nascent polypeptide-associated complex A/1.9.2,with two alternatively spliced isoform,acting as a muscle specific isoform
UniProtKB/Swiss-Prot Function: Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).
UniProtKB/Swiss-Prot Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Gene Ontology (GO) - Molecular Function for NACA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity ISS --
GO:0005515 protein binding IPI 21903422
GO:0017025 TBP-class protein binding ISS --
genes like me logo Genes that share ontologies with NACA: view
genes like me logo Genes that share phenotypes with NACA: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NACA Gene

Localization for NACA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NACA Gene

Cytoplasm. Nucleus.
Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NACA Gene COMPARTMENTS Subcellular localization image for NACA gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NACA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005854 nascent polypeptide-associated complex TAS 8047162
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with NACA: view

Pathways for NACA Gene

SuperPathways for NACA Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with NACA: view

Pathways by source for NACA Gene

1 Qiagen pathway for NACA Gene

Gene Ontology (GO) - Biological Process for NACA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003231 cardiac ventricle development ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006412 translation TAS 8047162
GO:0010664 negative regulation of striated muscle cell apoptotic process ISS --
genes like me logo Genes that share ontologies with NACA: view

Transcripts for NACA Gene

Unigene Clusters for NACA Gene

Nascent polypeptide-associated complex alpha subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NACA Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: -
SP7:

Relevant External Links for NACA Gene

GeneLoc Exon Structure for
NACA
ECgene alternative splicing isoforms for
NACA

Expression for NACA Gene

mRNA expression in normal human tissues for NACA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NACA Gene

SOURCE GeneReport for Unigene cluster for NACA Gene Hs.505735

mRNA Expression by UniProt/SwissProt for NACA Gene

E9PAV3-NACAM_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with NACA: view

Orthologs for NACA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NACA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NACA 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NACA 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naca 36
  • 78.07 (n)
  • 69.86 (a)
Naca 16
Naca 37
  • 12 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 34 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 18 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Naca 36
  • 78.43 (n)
  • 70.71 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 94 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nacalpha 37
  • 59 (a)
OneToMany
Nacalpha 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea icd-2 37
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD2 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1556 37
  • 76 (a)
OneToMany
Species with no ortholog for NACA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NACA Gene

ENSEMBL:
Gene Tree for NACA (if available)
TreeFam:
Gene Tree for NACA (if available)

Paralogs for NACA Gene

Paralogs for NACA Gene

Selected SIMAP similar genes for NACA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with NACA: view

Variants for NACA Gene

Sequence variations from dbSNP and Humsavar for NACA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4788 -- 56,712,876(-) GACAT(A/T)GAATT synonymous-codon, reference, nc-transcript-variant
rs4901 -- 56,713,612(-) AATAT(A/C)CTCTT synonymous-codon, reference, nc-transcript-variant
rs4902 -- 56,714,419(-) GAAAT(A/C/G/T)GATGA synonymous-codon, missense, reference, nc-transcript-variant
rs898609 -- 56,713,026(-) CTCGC(C/T)GTATA intron-variant
rs1078604 -- 56,713,370(+) taggg(G/T)gtagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NACA Gene

Variant ID Type Subtype PubMed ID
esv22791 CNV Loss 19812545
esv2235195 CNV Deletion 18987734
esv2745929 CNV Deletion 23290073
esv1234122 CNV Deletion 17803354

Relevant External Links for NACA Gene

HapMap Linkage Disequilibrium report
NACA

Disorders for NACA Gene

(1) University of Copenhagen DISEASES for NACA Gene

(2) Novoseek inferred disease relationships for NACA Gene

Disease -log(P) Hits PubMed IDs
hepatitis b 10.4 1
tumors 0 1
genes like me logo Genes that share disorders with NACA: view

No data available for UniProtKB/Swiss-Prot for NACA Gene

Publications for NACA Gene

  1. NACA is a positive regulator of human erythroid-cell differentiation. (PMID: 15784678) Lopez S. … Gomez S. (J. Cell Sci. 2005) 3 4 23
  2. Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. (PMID: 12689679) Papachristou D.J. … Papavassiliou A.G. (Bone 2003) 3 4 23
  3. Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. (PMID: 15196207) Al-Shanti N. … Rowbottom A.W. (Immunology 2004) 3 4 23
  4. Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. (PMID: 15299025) Quelo I. … St-Arnaud R. (J. Biol. Chem. 2004) 4 23
  5. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U. … Mautner J.M. (Int. J. Cancer 2002) 3 4

Products for NACA Gene

Sources for NACA Gene

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