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NACA Gene

protein-coding GIFtS: 60

GC12M055392

nascent polypeptide-associated complex alpha subunit
(Previous name: nascent-polypeptide-associated complex alpha polypeptide )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Alpha-NAC ^³
HSD48 ^²
MGC117224 ^²
NAC-alpha ^³
NACA1 ^¹, ²

Descriptions
Allergen Hom s 2 ^³
nascent polypeptide-associated complex alpha subunit ^²
nascent-polypeptide-associated complex alpha polypeptide ^¹, ²

External Ids
HGNC: 7629¹
Entrez Gene: 4666²
UniProtKB: Q13765³
Ensembl: ENSG00000196531⁷

Search outside databases for aliases for NACA gene

Previous GC identifers: GC12M057078 GC12M057330 GC12M056820

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765

Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic

reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks

their interaction with the signal recognition particle (SRP), which normally targets nascent

secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein

translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN,

binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters

Gene Wiki entry for NACA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NACA gene

Entrez Gene cytogenetic band: 12q23-q24.1 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q23-q24.1

NACA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M055392: (about GC identifiers)

Start:	55,380,832 bp from pter
End:	55,405,350 bp from pter
Size:	24,519 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765 (See protein sequence)

Recommended Name: Nascent polypeptide-associated complex subunit alpha

Size: 215 amino acids; 23384 Da

Subunit: Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated

complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3

subunit. Both subunits can contact nascent polypeptide chains. Interacts with ASFV protein H339R

Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus

Allergen: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients.

Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin

manifestations

Secondary accessions: Q3KQV4 Q53A18 Q53G46

Post-translational modifications:

Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization.

Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity).

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001106672.1 NP_001106673.1 NP_001106674.1 NP_005585.1

ENSEMBL proteins:

ENSP00000349212 ENSP00000377469

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NACA1)
	Human Recombinant Proteins from Abnova (NACA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	8047162
GO:0005854	nascent polypeptide-associated complex	TAS	8047162

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Antibodies for NACA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NACA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NACA1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NACA)
	Novus Biologicals Antibodies for NACA

Assays for NACA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13765

ProtoNet protein and cluster: Q13765

UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765

Similarity: Belongs to the NAC-alpha family

Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain

Similarity: Contains 1 UBA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NACA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001113201

Applied Biosystems Silencer® siRNAs for NACA

Sigma-Aldrich siRNA for NACA

Sigma-Aldrich shRNA for NACA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001113201
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001113201
untagged cDNA clones in CMV expression vector (see all 4): NM_001113201

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001113203

UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765

Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic

reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks

their interaction with the signal recognition particle (SRP), which normally targets nascent

secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein

translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN,

binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters

Genatlas biochemistry entry for NACA:

nascent polypeptide-associated complex A/1.9.2,with two alternatively spliced isoform,acting as a

muscle specific isoform

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NACA

5/22 Interacting proteins for NACA (ENSP00000349212³ Q13765²) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APLP1	P51693²	MINT-64152
FUNDC2	Q9BWH2²	MINT-64155
IGSF21	Q96ID5²	MINT-64153
ZHX1	Q9UKY1²	MINT-64157
NLRP1	ENSP00000269280³	STRING (score=.896)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006412	translation	TAS	8047162
GO:0015031	protein transport	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NACA

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NACA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001113201

Sigma-Aldrich siRNA for NACA

Sigma-Aldrich shRNA for NACA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001113201 NM_001113202 NM_001113203 NM_005594

REFSEQ mRNAs for NACA gene (4 alternative transcripts):

NM_001113201.1 NM_001113202.1 NM_001113203.1 NM_005594.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001113201 NM_001113202 NM_001113203 NM_005594

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001113201
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001113201
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001113201

Additional cDNA sequence:

AF054187.1 AK090650.1 AK096699.1 AK223085.1 AK293209.1 AK311904.1 AY034001.1 AY605660.1

AY911673.1 BC105120.1 BC105122.1 BC106041.1 CR450295.1 CR595197.1 CR599103.1 CR600016.1

CR600421.1 CR600671.1 CR603573.1 CR613486.1 CR618000.1 CR619360.1 CR624198.1 CR626308.1

X80909.1

24/75 DOTS entries (see all 75 ):

DT.100889874 DT.91783886 DT.91733258 DT.97868164 DT.91840150 DT.91718355 DT.95228035 DT.452984

DT.121209295 DT.100889890 DT.91783876 DT.100889895 DT.121209326 DT.121209266 DT.121209229 DT.95228084

DT.121232286 DT.100889896 DT.92056217 DT.121209132 DT.95228072 DT.121209279 DT.86993099 DT.91807751

24/1512 AceView cDNA sequences (see all 1512 ):

AI002459 AI828699 BM783608 CD678540 BG319509 BE275217 BM543012 T54741

BM855187 CR624198 CB145420 BG759702 BU182929 BP870848 CR603573 BE277036

AA670063 BM462874 CR595197 CR619360 AU139596 BU846127 BI858408 BF857436

highest scoring ESTs for NACA:

AF054187 AA082652 AA309058 AA730378 AK090650 AK096699 AL544444 AL558962 AL570572 AL580672

Unigene Cluster for NACA:

Nascent polypeptide-associated complex alpha subunit

Hs.505735 [show with all ESTs]

Unigene Representative Sequence: NM_001113203

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NACA (see all 7 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10
SP1:											-		-						-		-		-										-
SP2:					-		-				-		-						-		-		-
SP3:							-				-		-						-		-		-
SP4:					-		-				-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for NACA

2 Ensembl transcripts including schematic representations:

ENST00000356769 ENST00000393891

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NACA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NACA

¹ / ² / ³

7 probe-sets matching NACA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39740_g_at²^{, 3}	U95-A	6	1.00	0.64	0.75	0.96	AF054187	1.00	0.77	0.89	1
39739_at²^{, 3}	U95-A	4	1.00	0.31	0.89	0.99	AF054187	1.00	0.77	0.89	1
88137_at²^{, 3}	U95-E	6	0.75	0.36	0.89	1.06	AI992187	0.60	0.83	0.73	1
200735_x_at²^{, 3}	U133-A	6	1.00	0.55	--	--	NM_005594	0.60	0.83	0.73	1
208635_x_at²^{, 3}	U133-A	6	1.00	0.54	--	--	BF976260	0.40	0.75	0.60	1
200735_x_at²	U133Plus2	6	1.00	0.55	--	--	--	--	--	--	--
208635_x_at²	U133Plus2	6	1.00	0.54	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCACAAGCAA

SOURCE GeneReport for Unigene cluster: Hs.505735
Expression variation in blood from EXPOLDB for NACA
UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NACA gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC613013¹	--	similar to nascent polypeptide-associated complex alpha more	95.97(n) 100(a)	613013 XM_850343.1 XP_855436.1
chimpanzee (Pan troglodytes)	NACA¹	--	nascent polypeptide-associated complex alpha subunit	92.83(n) 92.06(a)	452434 XM_509538.2 XP_509538.2
cow (Bos taurus)	NACA¹	--	nascent polypeptide-associated complex alpha subunit	95.5(n) 99.53(a)	513312 NM_001014916.2 NP_001014916.1
rat (Rattus norvegicus)	Naca¹	--	nascent-polypeptide-associated complex alpha polypeptide	84.34(n) 91.16(a)	288770 XM_213821.3 XP_213821.2
mouse (Mus musculus)	Naca^{1, 5}	10⁵	nascent polypeptide-associated complex alpha polypeptide^{1, 5}	90.23(n)¹ 99.07(a)¹	17938¹ NM_013608.2¹ NP_038636.2¹ AI956211⁵ AK146149⁵ (see all 29)

About this table Species with no ortholog for NACA

ENSEMBL Gene Tree for NACA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NACA gene

NACA3P² NACAD² NACA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/72 NCBI SNPs in NACA are shown (see all 72 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2958127^1,2	A,C,F,H,O	55400574(-)	`TACAGA/TGAAGA`	2	V/E	mis¹ int¹		11		EU EA WA NA	980
	rs2926743^1,2	A,C,F,H,O	55400367(-)	`CTCTTC/TTTCAT`	2	F/S	mis¹ int¹ trp³		15		EU EA WA NA	1400
	rs3214051^1,2	A,C,F,H	55405503(-)	`TTAGTT/CCTTGT`	3	--	ut5¹ ng3¹ ese³		7		EA MN EU WA	3166
	rs2958149^1,2	A,C,F	55396059(+)	`GAGGCG/AGCAGC`	2	P/L	mis¹ int¹		1		EA	1498
	rs2926747^1,2	A,C,F	55396198(-)	`CACCCA/TCCCCA`	2	S/T	mis¹ int¹		1		EA	1490
	rs11834498^1,2	C,F,H	55400112(+)	`CTTTGG/CGAGCC`	2	R/P	mis¹ int¹		5		EU EA WA NA	510
	rs17118953^1,2	C,F,H	55401136(+)	`ACTCTT/CCTGAA`	2	E/K	mis¹ int¹		11		NA EU EA WA	980
--	rs2860482^1,2	A,C	55392205(+)	`TTTCAA/CCGTGT`	1	--	ng5¹		0	--	--	--	--
--	rs11833256^1,2	H	55398360(+)	`GGGATG/AGGGTA`	2	L/P	mis¹ int¹		4		EU EA WA	418
--	rs12423816^1,2	A	55396077(+)	`CATCAC/GCAGGG`	2	A/G	mis¹ int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for NACA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601234

2 Novoseek disease relationships for NACA gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis b	12.77	1	15986874 (1)
tumors	0.00	1	9202657 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/49 PubMed articles for NACA gene (see all 49 ):

NACA is a positive regulator of human erythroid-cell differentiation. (PubMed id 15784678)^{1, 3, 4} Lopez S....Gomez S. (2005)
Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. (PubMed id 15196207)^{1, 3, 4} Al-Shanti N.... Rowbottom A.W. (2004)
Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. (PubMed id 12689679)^{1, 3, 4} Papachristou D.J....Papavassiliou A.G. (2003)
Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)^{3, 4} Marques A.C.... Kaessmann H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function. (PubMed id 12684039)^{3, 4} Stilo R.... Vito P. (2003)
Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)^{3, 4} Behrends U.... Mautner J.M. (2002)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{3, 4} Zhang Q.H....Chen Z. (2000)
The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions. (PubMed id 10982809)^{3, 4} Beatrix B.... Wiedmann M. (2000)
A protein complex required for signal-sequence-specific sorting and translocation. (PubMed id 8047162)^{2, 3} Wiedmann B....Wiedmann M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4666	HGNC: 7629	AceView: NACA	Ensembl:ENSG00000196531	euGenes: HUgn4666
ECgene: NACA	H-InvDB: NACA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NACA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NACA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NACA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NACA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NACA		Antibodies for NACA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NACA		Browse small molecules at Sigma-Aldrich
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NACA Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for NACA

Summaries
for NACA

Genomic Location
for NACA

Proteins
for NACA

Protein Domains/
Families
for NACA

Gene Function
for NACA

Pathways & Interactions
for NACA

Drugs & Compounds
for NACA

Transcripts
for NACA

Expression
for NACA

Orthologs
for NACA

Paralogs
for NACA

SNPs/Variants
for NACA

Disorders & Mutations
for NACA

Medical News
for NACA

Publications
for NACA

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Genome Databases showing NACA

Other Databases showing NACA

Specialized Databases showing NACA

Licensable Technologies
for NACA

Services
for NACA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NACA Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor NACA

Summariesfor NACA

Genomic Locationfor NACA

Proteinsfor NACA

Protein Domains/Familiesfor NACA

Gene Functionfor NACA

Pathways & Interactionsfor NACA

Drugs & Compoundsfor NACA

Transcriptsfor NACA

Expression for NACA

Orthologsfor NACA

Paralogsfor NACA

SNPs/Variantsfor NACA

Disorders & Mutationsfor NACA

Medical Newsfor NACA

Publicationsfor NACA

Search for NACA

Genome Databases showing NACA

Other Databases showing NACA

Specialized Databases showing NACA

Licensable Technologiesfor NACA

Servicesfor NACA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NACA

Summaries
for NACA

Genomic Location
for NACA

Proteins
for NACA

Protein Domains/
Families
for NACA

Gene Function
for NACA

Pathways & Interactions
for NACA

Drugs & Compounds
for NACA

Transcripts
for NACA

Expression
for NACA

Orthologs
for NACA

Paralogs
for NACA

SNPs/Variants
for NACA

Disorders & Mutations
for NACA

Medical News
for NACA

Publications
for NACA

Licensable Technologies
for NACA

Services
for NACA