Aliases for NABP2 Gene
- Nucleic Acid Binding Protein 2 2 3 5
- Sensor Of Single-Strand DNA Complex Subunit B1 2 3 4
- Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2B 3 4
- Oligonucleotide/Oligosaccharide-Binding Fold Containing 2B 2 3
- Single-Stranded DNA-Binding Protein 1 3 4
- Single Strand DNA-Binding Protein 1 2 3
- Nucleic Acid-Binding Protein 2 3 4
External Ids for NABP2 Gene
Previous HGNC Symbols for NABP2 Gene
Previous GeneCards Identifiers for NABP2 Gene
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
GeneCards Summary for NABP2 Gene
NABP2 (Nucleic Acid Binding Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP1.
UniProtKB/Swiss-Prot for NABP2 Gene
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.