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Aliases for NABP2 Gene

Aliases for NABP2 Gene

  • Nucleic Acid Binding Protein 2 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit B1 2 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2B 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold Containing 2B 2 3
  • Single-Stranded DNA-Binding Protein 1 3 4
  • Single Strand DNA-Binding Protein 1 2 3
  • Nucleic Acid-Binding Protein 2 3 4
  • Sensor Of SsDNA Subunit B1 3 4
  • SOSS-B1 3 4
  • OBFC2B 3 4
  • HSSB1 3 4
  • SSB1 3 4
  • LP3587 3

External Ids for NABP2 Gene

Previous HGNC Symbols for NABP2 Gene

  • OBFC2B

Previous GeneCards Identifiers for NABP2 Gene

  • GC12P056616

Summaries for NABP2 Gene

Entrez Gene Summary for NABP2 Gene

  • Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

GeneCards Summary for NABP2 Gene

NABP2 (Nucleic Acid Binding Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP1.

UniProtKB/Swiss-Prot for NABP2 Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NABP2 Gene

Genomics for NABP2 Gene

Regulatory Elements for NABP2 Gene

Promoters for NABP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NABP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NABP2 Gene

Chromosome:
12
Start:
56,222,015 bp from pter
End:
56,229,854 bp from pter
Size:
7,840 bases
Orientation:
Plus strand

Genomic View for NABP2 Gene

Genes around NABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NABP2 Gene

Proteins for NABP2 Gene

  • Protein details for NABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ15-SOSB1_HUMAN
    Recommended name:
    SOSS complex subunit B1
    Protein Accession:
    Q9BQ15
    Secondary Accessions:
    • A6NDF8
    • Q6XYC8

    Protein attributes for NABP2 Gene

    Size:
    211 amino acids
    Molecular mass:
    22338 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7.
    SequenceCaution:
    • Sequence=AAP34465.1; Type=Frameshift; Positions=169; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NABP2 Gene

    Alternative splice isoforms for NABP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NABP2 Gene

Proteomics data for NABP2 Gene at MOPED

Post-translational modifications for NABP2 Gene

  • Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NABP2 Gene

No data available for DME Specific Peptides for NABP2 Gene

Domains & Families for NABP2 Gene

Protein Domains for NABP2 Gene

Suggested Antigen Peptide Sequences for NABP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ15

UniProtKB/Swiss-Prot:

SOSB1_HUMAN :
  • Contains 1 OB DNA-binding domain.
  • Belongs to the SOSS-B family. SOSS-B1 subfamily.
Domain:
  • Contains 1 OB DNA-binding domain.
Family:
  • Belongs to the SOSS-B family. SOSS-B1 subfamily.
genes like me logo Genes that share domains with NABP2: view

No data available for Gene Families for NABP2 Gene

Function for NABP2 Gene

Molecular function for NABP2 Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Gene Ontology (GO) - Molecular Function for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IDA 18449195
GO:0098505 G-rich strand telomeric DNA binding IDA 25589350
genes like me logo Genes that share ontologies with NABP2: view
genes like me logo Genes that share phenotypes with NABP2: view

Animal Models for NABP2 Gene

MGI Knock Outs for NABP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NABP2 Gene

Localization for NABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NABP2 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NABP2 Gene COMPARTMENTS Subcellular localization image for NABP2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070876 SOSS complex IDA 18449195
genes like me logo Genes that share ontologies with NABP2: view

Pathways & Interactions for NABP2 Gene

genes like me logo Genes that share pathways with NABP2: view

Pathways by source for NABP2 Gene

2 Reactome pathways for NABP2 Gene

Gene Ontology (GO) - Biological Process for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 19605351
GO:0006974 cellular response to DNA damage stimulus IMP 18449195
GO:0007093 mitotic cell cycle checkpoint IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
GO:0051972 NOT regulation of telomerase activity IMP 25589350
genes like me logo Genes that share ontologies with NABP2: view

No data available for SIGNOR curated interactions for NABP2 Gene

Drugs & Compounds for NABP2 Gene

No Compound Related Data Available

Transcripts for NABP2 Gene

Unigene Clusters for NABP2 Gene

Nucleic acid binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NABP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5:
SP6: - - - - -

Relevant External Links for NABP2 Gene

GeneLoc Exon Structure for
NABP2
ECgene alternative splicing isoforms for
NABP2

Expression for NABP2 Gene

mRNA expression in normal human tissues for NABP2 Gene

Protein differential expression in normal tissues from HIPED for NABP2 Gene

This gene is overexpressed in Fetal testis (31.7), Lymph node (26.4), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NABP2 Gene



SOURCE GeneReport for Unigene cluster for NABP2 Gene Hs.240170

genes like me logo Genes that share expression patterns with NABP2: view

Protein tissue co-expression partners for NABP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NABP2 Gene

Orthologs for NABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NABP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NABP2 36
  • 94 (a)
OneToOne
NABP2 35
  • 92.26 (n)
  • 94.31 (a)
dog
(Canis familiaris)
Mammalia NABP2 35
  • 92.58 (n)
  • 95.73 (a)
NABP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nabp2 36
  • 92 (a)
OneToOne
Nabp2 16
Nabp2 35
  • 87.52 (n)
  • 93.36 (a)
rat
(Rattus norvegicus)
Mammalia Nabp2 35
  • 87.99 (n)
  • 92.42 (a)
lizard
(Anolis carolinensis)
Reptilia NABP2 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15476 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nabp2 35
  • 68.47 (n)
  • 73.89 (a)
Str.11818 35
zebrafish
(Danio rerio)
Actinopterygii NABP2 36
  • 63 (a)
OneToOne
LOC101882738 35
  • 67.35 (n)
  • 69.23 (a)
wufc60e10 35
fruit fly
(Drosophila melanogaster)
Insecta CG5181 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G3.8 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4773 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for NABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NABP2 Gene

ENSEMBL:
Gene Tree for NABP2 (if available)
TreeFam:
Gene Tree for NABP2 (if available)

Paralogs for NABP2 Gene

Paralogs for NABP2 Gene

(1) SIMAP similar genes for NABP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NABP2 Gene

genes like me logo Genes that share paralogs with NABP2: view

Variants for NABP2 Gene

Sequence variations from dbSNP and Humsavar for NABP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1274494 -- 56,224,314(-) CGGCT(A/G)GCCTC intron-variant, upstream-variant-2KB
rs7350607 -- 56,227,739(+) agcaa(A/G)gagtt intron-variant
rs10676451 -- 56,226,574(+) TTTTT(-/T)GAGAC intron-variant
rs10676452 -- 56,226,733(+) TTTTT(-/T/TTTTTTTTTTTTT)GAGAT intron-variant
rs10876880 -- 56,227,258(+) GTAAT(C/T)CCAGC intron-variant

Variation tolerance for NABP2 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NABP2 Gene

HapMap Linkage Disequilibrium report
NABP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NABP2 Gene

Disorders for NABP2 Gene

Relevant External Links for NABP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NABP2

No disorders were found for NABP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NABP2 Gene

Publications for NABP2 Gene

  1. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. (PMID: 21659603) Cotta-Ramusino C. … Elledge S.J. (Science 2011) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  4. FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. (PMID: 25249620) Chen Z.W. … Xu L. (Nucleic Acids Res. 2014) 3
  5. Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. (PMID: 24753408) Bolderson E. … Richard D.J. (Nucleic Acids Res. 2014) 3

Products for NABP2 Gene

Sources for NABP2 Gene

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