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Aliases for NABP2 Gene

Aliases for NABP2 Gene

  • Nucleic Acid Binding Protein 2 2 3
  • Sensor Of Single-Strand DNA Complex Subunit B1 2 3 4
  • OBFC2B 3 4 6
  • SSB1 3 4 6
  • Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2B 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold Containing 2B 2 3
  • Single-Stranded DNA-Binding Protein 1 3 4
  • Single Strand DNA-Binding Protein 1 2 3
  • Nucleic Acid-Binding Protein 2 3 4
  • Sensor Of SsDNA Subunit B1 3 4
  • SOSS-B1 3 4
  • HSSB1 3 4
  • SOSS Complex Subunit B1 3
  • LP3587 3

External Ids for NABP2 Gene

Previous Symbols for NABP2 Gene

  • OBFC2B

Summaries for NABP2 Gene

Entrez Gene Summary for NABP2 Gene

  • Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

GeneCards Summary for NABP2 Gene

NABP2 (Nucleic Acid Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is NABP1.

UniProtKB/Swiss-Prot for NABP2 Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NABP2 Gene

Genomics for NABP2 Gene

Genomic Location for NABP2 Gene

Start:
56,222,015 bp from pter
End:
56,229,854 bp from pter
Size:
7,840 bases
Orientation:
Plus strand

Genomic View for NABP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NABP2 Gene

No data available for Regulatory Elements for NABP2 Gene

Proteins for NABP2 Gene

  • Protein details for NABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ15-SOSB1_HUMAN
    Recommended name:
    SOSS complex subunit B1
    Protein Accession:
    Q9BQ15
    Secondary Accessions:
    • A6NDF8
    • Q6XYC8

    Protein attributes for NABP2 Gene

    Size:
    211 amino acids
    Molecular mass:
    22338 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7.
    SequenceCaution:
    • Sequence=AAP34465.1; Type=Frameshift; Positions=169; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NABP2 Gene

    Alternative splice isoforms for NABP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NABP2 Gene

Proteomics data for NABP2 Gene at MOPED

Post-translational modifications for NABP2 Gene

  • Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NABP2 Gene

No data available for DME Specific Peptides for NABP2 Gene

Domains for NABP2 Gene

Protein Domains for NABP2 Gene

UniProtKB/Swiss-Prot:

SOSB1_HUMAN
Domain:
  • Contains 1 OB DNA-binding domain.:
    • Q9BQ15
Family:
  • Belongs to the SOSS-B family. SOSS-B1 subfamily.:
    • Q9BQ15
genes like me logo Genes that share domains with NABP2: view

No data available for Gene Families for NABP2 Gene

Function for NABP2 Gene

Molecular function for NABP2 Gene

UniProtKB/Swiss-Prot Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Gene Ontology (GO) - Molecular Function for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding IDA 18449195
GO:0005515 protein binding IPI 18449195
genes like me logo Genes that share ontologies with NABP2: view
genes like me logo Genes that share phenotypes with NABP2: view

Animal Models for NABP2 Gene

MGI Knock Outs for NABP2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NABP2 Gene

Localization for NABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NABP2 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.

Gene Ontology (GO) - Cellular Components for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18449195
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070876 SOSS complex IDA 18449195
genes like me logo Genes that share ontologies with NABP2: view

Pathways for NABP2 Gene

SuperPathways for NABP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 19605351
GO:0006281 DNA repair IMP 18449195
GO:0006974 cellular response to DNA damage stimulus IMP 18449195
GO:0007093 mitotic cell cycle checkpoint IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with NABP2: view

No data available for Pathways by source for NABP2 Gene

Transcripts for NABP2 Gene

Unigene Clusters for NABP2 Gene

Nucleic acid binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NABP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5:
SP6: - - - - -

Relevant External Links for NABP2 Gene

GeneLoc Exon Structure for
NABP2
ECgene alternative splicing isoforms for
NABP2

Expression for NABP2 Gene

mRNA expression in normal human tissues for NABP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NABP2 Gene

SOURCE GeneReport for Unigene cluster for NABP2 Gene Hs.240170

genes like me logo Genes that share expressions with NABP2: view

Orthologs for NABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NABP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NABP2 36
  • 92.26 (n)
  • 94.31 (a)
NABP2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NABP2 36
  • 92.58 (n)
  • 95.73 (a)
NABP2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nabp2 36
  • 87.52 (n)
  • 93.36 (a)
Nabp2 16
Nabp2 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nabp2 36
  • 87.99 (n)
  • 92.42 (a)
lizard
(Anolis carolinensis)
Reptilia NABP2 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15476 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nabp2 36
  • 68.47 (n)
  • 73.89 (a)
Str.11818 36
zebrafish
(Danio rerio)
Actinopterygii LOC101882738 36
  • 67.35 (n)
  • 69.23 (a)
NABP2 37
  • 63 (a)
OneToOne
wufc60e10 36
fruit fly
(Drosophila melanogaster)
Insecta CG5181 37
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G3.8 37
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4773 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for NABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NABP2 Gene

ENSEMBL:
Gene Tree for NABP2 (if available)
TreeFam:
Gene Tree for NABP2 (if available)

Paralogs for NABP2 Gene

Paralogs for NABP2 Gene

Selected SIMAP similar genes for NABP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NABP2 Gene

genes like me logo Genes that share paralogs with NABP2: view

Variants for NABP2 Gene

Sequence variations from dbSNP and Humsavar for NABP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1274494 -- 56,224,314(-) CGGCT(A/G)GCCTC upstream-variant-2KB, intron-variant
rs4759216 -- 56,227,285(-) CATTC(G/T)CCTGC intron-variant
rs7350607 -- 56,227,739(+) agcaa(A/G)gagtt intron-variant
rs7350620 -- 56,227,979(+) cctga(A/G)gctgg intron-variant
rs7955718 -- 56,226,816(+) cctcc(C/T)gggtt intron-variant

Relevant External Links for NABP2 Gene

HapMap Linkage Disequilibrium report
NABP2

No data available for Structural Variations from Database of Genomic Variants (DGV) for NABP2 Gene

Disorders for NABP2 Gene

No disorders were found for NABP2 Gene.

No data available for UniProtKB/Swiss-Prot for NABP2 Gene

Publications for NABP2 Gene

  1. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. (PMID: 18449195) Richard D.J. … Khanna K.K. (Nature 2008) 3 4
  2. hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y. … Wang W. (J. Biol. Chem. 2009) 3 4
  3. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J. … Chen J. (Mol. Cell 2009) 3 4
  4. INTS3 controls the hSSB1-mediated DNA damage response. (PMID: 19786574) Skaar J.R. … Pagano M. (J. Cell Biol. 2009) 3
  5. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PMID: 20133760) Malovannaya A. … Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for NABP2 Gene

Sources for NABP2 Gene

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