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Aliases for NABP1 Gene

Aliases for NABP1 Gene

  • Nucleic Acid Binding Protein 1 2 3
  • Sensor Of Single-Strand DNA Complex Subunit B2 2 3 4
  • Single-Stranded DNA-Binding Protein 2 2 3 4
  • OBFC2A 3 4 6
  • SSB2 3 4 6
  • Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2A 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A 2 3
  • Nucleic Acid-Binding Protein 1 3 4
  • Sensor Of SsDNA Subunit B2 3 4
  • SOSS-B2 3 4
  • SOSS Complex Subunit B2 3
  • HSSB2 4

External Ids for NABP1 Gene

Previous HGNC Symbols for NABP1 Gene

  • OBFC2A

Previous GeneCards Identifiers for NABP1 Gene

  • GC02P192543

Summaries for NABP1 Gene

Entrez Gene Summary for NABP1 Gene

  • Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

GeneCards Summary for NABP1 Gene

NABP1 (Nucleic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with NABP1 include leukemia, acute promyelocytic. GO annotations related to this gene include RNA binding and single-stranded DNA binding. An important paralog of this gene is NABP2.

UniProtKB/Swiss-Prot for NABP1 Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NABP1 Gene

Genomics for NABP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NABP1 Gene

Start:
191,678,068 bp from pter
End:
191,696,659 bp from pter
Size:
18,592 bases
Orientation:
Plus strand

Genomic View for NABP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NABP1 Gene

No data available for Regulatory Elements for NABP1 Gene

Proteins for NABP1 Gene

  • Protein details for NABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AH0-SOSB2_HUMAN
    Recommended name:
    SOSS complex subunit B2
    Protein Accession:
    Q96AH0
    Secondary Accessions:
    • Q658Y8
    • Q9H5X6

    Protein attributes for NABP1 Gene

    Size:
    204 amino acids
    Molecular mass:
    22423 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1.

    Alternative splice isoforms for NABP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NABP1 Gene

Proteomics data for NABP1 Gene at MOPED

Post-translational modifications for NABP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NABP1 Gene

Domains for NABP1 Gene

Protein Domains for NABP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AH0

UniProtKB/Swiss-Prot:

SOSB2_HUMAN :
  • Q96AH0
Domain:
  • Contains 1 OB DNA-binding domain.
Family:
  • Belongs to the SOSS-B family. SOSS-B2 subfamily.
genes like me logo Genes that share domains with NABP1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NABP1 Gene

Function for NABP1 Gene

Molecular function for NABP1 Gene

UniProtKB/Swiss-Prot Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Gene Ontology (GO) - Molecular Function for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding ISS --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NABP1: view

Animal Model Products

CRISPR Products

miRNA for NABP1 Gene

miRTarBase miRNAs that target NABP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NABP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NABP1 Gene

Localization for NABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NABP1 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Gene Ontology (GO) - Cellular Components for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19683501
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070876 SOSS complex IDA 18449195
genes like me logo Genes that share ontologies with NABP1: view

No data available for Subcellular locations from COMPARTMENTS for NABP1 Gene

Pathways for NABP1 Gene

SuperPathways for NABP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 19605351
GO:0006281 DNA repair IMP 19683501
GO:0006974 cellular response to DNA damage stimulus IMP 19683501
GO:0007093 mitotic cell cycle checkpoint IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with NABP1: view

No data available for Pathways by source for NABP1 Gene

Transcripts for NABP1 Gene

Unigene Clusters for NABP1 Gene

Nucleic acid binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NABP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NABP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NABP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11:
SP12: -

Relevant External Links for NABP1 Gene

GeneLoc Exon Structure for
NABP1
ECgene alternative splicing isoforms for
NABP1

Expression for NABP1 Gene

mRNA expression in normal human tissues for NABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NABP1 Gene

This gene is overexpressed in Whole Blood (7.0) and Spleen (4.3).

SOURCE GeneReport for Unigene cluster for NABP1 Gene Hs.591610

genes like me logo Genes that share expressions with NABP1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for NABP1 Gene

Orthologs for NABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OBFC2A 35
  • 99.84 (n)
  • 99.51 (a)
OBFC2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NABP1 35
  • 91.83 (n)
  • 87.75 (a)
NABP1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NABP1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nabp1 35
  • 88.72 (n)
  • 83.84 (a)
Nabp1 16
Nabp1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NABP1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NABP1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nabp1 35
  • 87.88 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves NABP1 36
  • 72 (a)
OneToOne
OBFC2A 35
  • 74.3 (n)
  • 75.62 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2385 35
zebrafish
(Danio rerio)
Actinopterygii nabp1a 35
  • 65.18 (n)
  • 66.83 (a)
nabp1a 36
  • 61 (a)
OneToMany
nabp1b 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5181 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G3.8 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for NABP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NABP1 Gene

ENSEMBL:
Gene Tree for NABP1 (if available)
TreeFam:
Gene Tree for NABP1 (if available)

Paralogs for NABP1 Gene

Paralogs for NABP1 Gene

Selected SIMAP similar genes for NABP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NABP1: view

Variants for NABP1 Gene

Sequence variations from dbSNP and Humsavar for NABP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1133214 -- 191,678,494(+) CCCCT(C/T)CTCTC utr-variant-5-prime, intron-variant, nc-transcript-variant
rs3194744 -- 191,678,497(+) CTTCT(C/G)TCGCC utr-variant-5-prime, intron-variant, nc-transcript-variant
rs3209207 -- 191,678,523(+) CGCCC(C/T)TCTGC utr-variant-5-prime, intron-variant, nc-transcript-variant
rs4377279 -- 191,678,958(+) CTAGC(A/C)ACCCC intron-variant
rs4386269 -- 191,678,423(+) TTTTT(C/T)TTTTC utr-variant-5-prime, intron-variant, nc-transcript-variant

Relevant External Links for NABP1 Gene

HapMap Linkage Disequilibrium report
NABP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NABP1 Gene

Disorders for NABP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NABP1 Gene including...

Search for NABP1 Gene in MalaCards »
genes like me logo Genes that share disorders with NABP1: view

No data available for UniProtKB/Swiss-Prot for NABP1 Gene

Publications for NABP1 Gene

  1. hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y. … Wang W. (J. Biol. Chem. 2009) 3 4
  2. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J. … Chen J. (Mol. Cell 2009) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for NABP1 Gene

Sources for NABP1 Gene

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