Aliases for NABP1 Gene
- Nucleic Acid Binding Protein 1 2 3 5
- Sensor Of Single-Strand DNA Complex Subunit B2 2 3 4
- Single-Stranded DNA-Binding Protein 2 2 3 4
- Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2A 3 4
- Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A 2 3
- Nucleic Acid-Binding Protein 1 3 4
External Ids for NABP1 Gene
Previous HGNC Symbols for NABP1 Gene
Previous GeneCards Identifiers for NABP1 Gene
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
GeneCards Summary for NABP1 Gene
NABP1 (Nucleic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with NABP1 include leukemia, acute promyelocytic, somatic. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP2.
UniProtKB/Swiss-Prot for NABP1 Gene
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.