Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NABP1 Gene

Aliases for NABP1 Gene

  • Nucleic Acid Binding Protein 1 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit B2 2 3 4
  • Single-Stranded DNA-Binding Protein 2 2 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2A 3 4
  • Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A 2 3
  • Sensor Of SsDNA Subunit B2 3 4
  • SOSS-B2 3 4
  • OBFC2A 3 4
  • SSB2 3 4
  • Nucleic Acid-Binding Protein 1 4
  • SOSS Complex Subunit B2 3
  • HSSB2 4

External Ids for NABP1 Gene

Previous HGNC Symbols for NABP1 Gene

  • OBFC2A

Previous GeneCards Identifiers for NABP1 Gene

  • GC02P192543

Summaries for NABP1 Gene

Entrez Gene Summary for NABP1 Gene

  • Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

GeneCards Summary for NABP1 Gene

NABP1 (Nucleic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with NABP1 include Acute Promyelocytic Leukemia. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NABP2.

UniProtKB/Swiss-Prot for NABP1 Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Additional gene information for NABP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NABP1 Gene

Genomics for NABP1 Gene

GeneHancer (GH) Regulatory Elements for NABP1 Gene

Promoters and enhancers for NABP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I191674 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 585.7 +1.0 975 8.4 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 NABP1 GC02P191680 CAVIN2 LOC105373813 STAT1 ENSG00000274845
GH02I191624 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 42.2 -52.4 -52428 2.6 ELF3 FOXA2 ZBTB40 RARA FOS CEBPB KLF16 ZNF341 CEBPA NR2C1 NABP1 STAT4 GC02P191616
GH02I191617 Enhancer 1.2 FANTOM5 Ensembl ENCODE 35.3 -59.2 -59195 3.5 PKNOX1 BMI1 IRF4 RELA ZNF316 GATA3 NFATC1 ATF7 ETV6 NFE2 NABP1 GC02P191616
GH02I191570 Enhancer 1.4 FANTOM5 Ensembl ENCODE 24.8 -106.6 -106613 2.1 PKNOX1 ATF1 ARNT TCF12 E2F8 ARID2 ATF7 NCOA1 REST ZNF592 NABP1 GC02P191616 GC02P191496
GH02I191611 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 25.8 -65.7 -65657 2.2 PKNOX1 JUN DPF2 IRF4 JUND ZNF316 NFIC POLR2A BCL11A IKZF1 NABP1 GC02P191616 GC02P191496
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NABP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NABP1 Gene

Genomic Locations for NABP1 Gene
chr2:191,678,068-191,696,659
(GRCh38/hg38)
Size:
18,592 bases
Orientation:
Plus strand
chr2:192,542,794-192,561,385
(GRCh37/hg19)

Genomic View for NABP1 Gene

Genes around NABP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NABP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NABP1 Gene

Proteins for NABP1 Gene

  • Protein details for NABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AH0-SOSB2_HUMAN
    Recommended name:
    SOSS complex subunit B2
    Protein Accession:
    Q96AH0
    Secondary Accessions:
    • Q658Y8
    • Q9H5X6

    Protein attributes for NABP1 Gene

    Size:
    204 amino acids
    Molecular mass:
    22423 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1.

    Alternative splice isoforms for NABP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NABP1 Gene

Post-translational modifications for NABP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NABP1 Gene

Domains & Families for NABP1 Gene

Gene Families for NABP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NABP1 Gene

Suggested Antigen Peptide Sequences for NABP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AH0

UniProtKB/Swiss-Prot:

SOSB2_HUMAN :
  • Belongs to the SOSS-B family. SOSS-B2 subfamily.
Family:
  • Belongs to the SOSS-B family. SOSS-B2 subfamily.
genes like me logo Genes that share domains with NABP1: view

Function for NABP1 Gene

Molecular function for NABP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Phenotypes From GWAS Catalog for NABP1 Gene

Gene Ontology (GO) - Molecular Function for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA,ISS --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19683501
genes like me logo Genes that share ontologies with NABP1: view
genes like me logo Genes that share phenotypes with NABP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NABP1 Gene

Localization for NABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NABP1 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NABP1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region ISS,IEA --
GO:0005634 nucleus IEA,IDA 19683501
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol IDA --
GO:0070876 SOSS complex IDA 18449195
genes like me logo Genes that share ontologies with NABP1: view

Pathways & Interactions for NABP1 Gene

genes like me logo Genes that share pathways with NABP1: view

Pathways by source for NABP1 Gene

2 Reactome pathways for NABP1 Gene

Gene Ontology (GO) - Biological Process for NABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 19605351
GO:0006281 DNA repair IMP 19683501
GO:0006974 cellular response to DNA damage stimulus IMP 19683501
GO:0007093 mitotic cell cycle checkpoint IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with NABP1: view

No data available for SIGNOR curated interactions for NABP1 Gene

Drugs & Compounds for NABP1 Gene

No Compound Related Data Available

Transcripts for NABP1 Gene

Unigene Clusters for NABP1 Gene

Nucleic acid binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NABP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11:
SP12: -

Relevant External Links for NABP1 Gene

GeneLoc Exon Structure for
NABP1
ECgene alternative splicing isoforms for
NABP1

Expression for NABP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NABP1 Gene

This gene is overexpressed in Whole Blood (x7.0) and Spleen (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of NABP1 Gene:

NABP1

SOURCE GeneReport for Unigene cluster for NABP1 Gene:

Hs.591610

Evidence on tissue expression from TISSUES for NABP1 Gene

  • Intestine(4.3)
  • Bone marrow(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NABP1 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Organs:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with NABP1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NABP1 Gene

Orthologs for NABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OBFC2A 34 33
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NABP1 33 34
  • 91.83 (n)
mouse
(Mus musculus)
Mammalia Nabp1 33 16 34
  • 88.72 (n)
rat
(Rattus norvegicus)
Mammalia Nabp1 33
  • 87.88 (n)
oppossum
(Monodelphis domestica)
Mammalia NABP1 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NABP1 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NABP1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves OBFC2A 33
  • 74.3 (n)
NABP1 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nabp1a 33 34
  • 65.18 (n)
nabp1b 34
  • 52 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2385 33
fruit fly
(Drosophila melanogaster)
Insecta CG5181 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G3.8 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
Species where no ortholog for NABP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NABP1 Gene

ENSEMBL:
Gene Tree for NABP1 (if available)
TreeFam:
Gene Tree for NABP1 (if available)

Paralogs for NABP1 Gene

Paralogs for NABP1 Gene

(1) SIMAP similar genes for NABP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NABP1: view

Variants for NABP1 Gene

Sequence variations from dbSNP and Humsavar for NABP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000267654 -- 191,682,565(+) C/T coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant
rs1000273384 -- 191,682,284(+) G/A intron_variant
rs1000325953 -- 191,681,899(+) A/G intron_variant
rs1000504882 -- 191,676,965(+) C/T upstream_transcript_variant
rs1000596631 -- 191,676,677(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NABP1 Gene

Variant ID Type Subtype PubMed ID
nsv834494 CNV gain 17160897

Variation tolerance for NABP1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NABP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NABP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NABP1 Gene

Disorders for NABP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NABP1 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards
Search NABP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NABP1

genes like me logo Genes that share disorders with NABP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NABP1 Gene

Publications for NABP1 Gene

  1. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J … Chen J (Molecular cell 2009) 3 4 58
  2. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y … Wang W (The Journal of biological chemistry 2009) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M … Jurisica I (Nature methods 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for NABP1 Gene

Sources for NABP1 Gene

Content
Loading form....