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Aliases for NAB2 Gene

Aliases for NAB2 Gene

  • NGFI-A Binding Protein 2 2 3
  • NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) 2 3 5
  • Melanoma-Associated Delayed Early Response Protein 3 4
  • EGR-1-Binding Protein 2 3 4
  • EGR1 Binding Protein 2 2 3
  • MADER 3 4
  • Protein MADER 4

External Ids for NAB2 Gene

Previous GeneCards Identifiers for NAB2 Gene

  • GC12P057457
  • GC12P057707
  • GC12P057199
  • GC12P055769
  • GC12P054521

Summaries for NAB2 Gene

Entrez Gene Summary for NAB2 Gene

  • This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAB2 Gene

NAB2 (NGFI-A Binding Protein 2) is a Protein Coding gene. Diseases associated with NAB2 include solitary fibrous tumor and meninges hemangiopericytoma. GO annotations related to this gene include transcription factor binding and transcription corepressor activity. An important paralog of this gene is NAB1.

UniProtKB/Swiss-Prot for NAB2 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Gene Wiki entry for NAB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAB2 Gene

Genomics for NAB2 Gene

Regulatory Elements for NAB2 Gene

Promoters for NAB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAB2 Gene

Chromosome:
12
Start:
57,088,894 bp from pter
End:
57,095,476 bp from pter
Size:
6,583 bases
Orientation:
Plus strand

Genomic View for NAB2 Gene

Genes around NAB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAB2 Gene

Proteins for NAB2 Gene

  • Protein details for NAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15742-NAB2_HUMAN
    Recommended name:
    NGFI-A-binding protein 2
    Protein Accession:
    Q15742
    Secondary Accessions:
    • B2RAK3
    • O76006
    • Q14797

    Protein attributes for NAB2 Gene

    Size:
    525 amino acids
    Molecular mass:
    56594 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Alternative splice isoforms for NAB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB2 Gene

Proteomics data for NAB2 Gene at MOPED

Post-translational modifications for NAB2 Gene

  • Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAB2 Gene

Domains & Families for NAB2 Gene

Protein Domains for NAB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15742

UniProtKB/Swiss-Prot:

NAB2_HUMAN :
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • Belongs to the NAB family.
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Family:
  • Belongs to the NAB family.
genes like me logo Genes that share domains with NAB2: view

No data available for Gene Families for NAB2 Gene

Function for NAB2 Gene

Molecular function for NAB2 Gene

GENATLAS Biochemistry:
NGFI-A (nerve growth factor induced clone A) binding protein 2 (ERG2 binding protein) highly expressed in brain and thymus,with an alternatively splicing isoform missing exon 3,and in vascular smooth muscle cell in response to injury
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
UniProtKB/Swiss-Prot Induction:
By serum and phorbol myristate acetate (PMA) stimulation.

Gene Ontology (GO) - Molecular Function for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with NAB2: view
genes like me logo Genes that share phenotypes with NAB2: view

Human Phenotype Ontology for NAB2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NAB2 Gene

MGI Knock Outs for NAB2:

Animal Model Products

miRNA for NAB2 Gene

miRTarBase miRNAs that target NAB2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NAB2 Gene

Localization for NAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB2 Gene

Nucleus. Note=Isoform 2 is not localized to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAB2 Gene COMPARTMENTS Subcellular localization image for NAB2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NAB2 Gene

Pathways & Interactions for NAB2 Gene

SuperPathways for NAB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0007399 nervous system development TAS 8668170
GO:0008283 cell proliferation TAS 8668170
GO:0014037 Schwann cell differentiation IEA --
GO:0016480 negative regulation of transcription from RNA polymerase III promoter IDA 8668170
genes like me logo Genes that share ontologies with NAB2: view

No data available for Pathways by source and SIGNOR curated interactions for NAB2 Gene

Drugs & Compounds for NAB2 Gene

(1) Drugs for NAB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NAB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAB2: view

Transcripts for NAB2 Gene

Unigene Clusters for NAB2 Gene

NGFI-A binding protein 2 (EGR1 binding protein 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAB2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for NAB2 Gene

GeneLoc Exon Structure for
NAB2
ECgene alternative splicing isoforms for
NAB2

Expression for NAB2 Gene

mRNA expression in normal human tissues for NAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAB2 Gene

This gene is overexpressed in Lung (19.6), Placenta (18.9), NK cells (16.3), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAB2 Gene



SOURCE GeneReport for Unigene cluster for NAB2 Gene Hs.159223

mRNA Expression by UniProt/SwissProt for NAB2 Gene

Q15742-NAB2_HUMAN
Tissue specificity: Widely expressed at low levels. Highly expressed in melanoma cell lines.
genes like me logo Genes that share expression patterns with NAB2: view

Protein tissue co-expression partners for NAB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NAB2 Gene

Orthologs for NAB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAB2 35
  • 93.52 (n)
  • 98.29 (a)
NAB2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAB2 35
  • 92.7 (n)
  • 98.1 (a)
NAB2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nab2 35
  • 89.14 (n)
  • 95.62 (a)
Nab2 16
Nab2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAB2 35
  • 99.81 (n)
  • 100 (a)
NAB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nab2 35
  • 89.97 (n)
  • 96.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NAB2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAB2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nab2 35
  • 60.93 (n)
  • 61 (a)
zebrafish
(Danio rerio)
Actinopterygii nab2 35
  • 56.68 (n)
  • 54.38 (a)
nab2 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nab 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-10 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6864 36
  • 35 (a)
OneToMany
Species with no ortholog for NAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB2 Gene

ENSEMBL:
Gene Tree for NAB2 (if available)
TreeFam:
Gene Tree for NAB2 (if available)

Paralogs for NAB2 Gene

Paralogs for NAB2 Gene

(1) SIMAP similar genes for NAB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAB2: view

Variants for NAB2 Gene

Sequence variations from dbSNP and Humsavar for NAB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs391648 -- 57,094,770(-) GTCTG(G/T)GTGAG utr-variant-3-prime
rs406270 -- 57,094,388(-) tctct(C/G)tctct intron-variant
rs412567 -- 57,094,392(-) tctgt(C/T)tctct intron-variant
rs425943 -- 57,094,768(-) CTGGG(G/T)GAGCC utr-variant-3-prime
rs434811 -- 57,094,750(-) TGAGG(G/T)CCTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAB2 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV Gain 17160897

Variation tolerance for NAB2 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAB2 Gene

HapMap Linkage Disequilibrium report
NAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAB2 Gene

Disorders for NAB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAB2 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
solitary fibrous tumor
meninges hemangiopericytoma
  • hemangiopericytoma of meninges
- elite association - COSMIC cancer census association via MalaCards
Search NAB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAB2

Genetic Association Database (GAD)
NAB2
Human Genome Epidemiology (HuGE) Navigator
NAB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAB2
genes like me logo Genes that share disorders with NAB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAB2 Gene

Publications for NAB2 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J. … Milbrandt J. (Mol. Cell. Biol. 1996) 2 3 4 23 67
  2. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PMID: 16574654) Srinivasan R. … Svaren J. (J. Biol. Chem. 2006) 3 23
  3. Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PMID: 12030330) Venken K. … Svaren J. (Neurogenetics 2002) 3 23
  4. Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. (PMID: 11567222) Abdulkadir S.A. … Milbrandt J. (Hum. Pathol. 2001) 3 23
  5. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. (PMID: 9722618) Qu Z. … Milbrandt J. (J. Cell Biol. 1998) 3 23

Products for NAB2 Gene

Sources for NAB2 Gene

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