Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAB2 Gene

protein-coding   GIFtS: 53
GCID: GC12P057457

NGFI-A binding protein 2 (EGR1 binding protein 2)

 Explore 20 diseases affiliated with
NAB2 via our new
 Human Malady Compendium 
Biological research products
for NAB2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NGFI-A Binding Protein 2 (EGR1 Binding Protein 2)1 2     EGR1 Binding Protein 22
MADER1 2 3     NGFI-A-Binding Protein 22
Melanoma-Associated Delayed Early Response Protein2 3     Protein MADER3
EGR-1-Binding Protein 22 3     

External Ids:    HGNC: 76271   Entrez Gene: 46652   Ensembl: ENSG000001668867   OMIM: 6023815   UniProtKB: Q157423   

Export aliases for NAB2 gene to outside databases

Previous GC identifers: GC12P057707 GC12P057199 GC12P055769 GC12P054521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAB2:
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress
transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can
homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress
transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is
mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced
transcript variants have been described, but their biological validity has not been determined. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742
Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks
repression ability (By similarity)

Gene Wiki entry for NAB2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAB2 gene promoter:
         Oct-B1   Elk-1   oct-B3   oct-B2   Pax-5   PPAR-gamma1   POU2F1   POU2F1a   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

NAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057457:  view genomic region     (about GC identifiers)

Start:
57,482,677 bp from pter      End:
57,489,259 bp from pter
Size:
6,583 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742 (See protein sequence)
Recommended Name: NGFI-A-binding protein 2  
Size: 525 amino acids; 56594 Da
Subunit: Homomultimers may associate with EGR1 bound to DNA (By similarity)
Subcellular location: Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity)
Secondary accessions: B2RAK3 O76006 Q14797
Alternative splicing: 3 isoforms:  Q15742-1   Q15742-2   Q15742-3   

Explore the universe of human proteins at neXtProt for NAB2: NX_Q15742

Post-translational modifications:

  • Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15742

  • NAB2 Protein expression data from MOPED and PaxDb:    About this image 
    NAB2 Protein Expression
    REFSEQ proteins: NP_005958.1  
    ENSEMBL proteins: 
     ENSP00000300131   ENSP00000341491   ENSP00000350309  

    Human Recombinant Protein Products for NAB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NAB2
    OriGene Protein Over-expression Lysate: NAB2
    OriGene Custom Protein Services for NAB2 
    GenScript Custom Purified and Recombinant Proteins Services for NAB2
    Novus Biologicals NAB2 Proteins
    Novus Biologicals NAB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NAB2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NAB2 for ontologies           About GeneDecksing



    NAB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NAB2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NAB2 
    GenScript Custom Superior Antibodies Services for NAB2
    Novus Biologicals NAB2 Antibodies
    Abcam antibodies for NAB2 
    Uscn Antibodies for NAB2
    ThermoFisher Antibodies for NAB2

    Assay Products for NAB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAB2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NAB2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NAB2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006989 NAB_co-repressor_dom
     IPR006988 Nab_N

    Graphical View of Domain Structure for InterPro Entry Q15742

    ProtoNet protein and cluster: Q15742

    UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742
    Domain: The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization
    Domain: The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression
    Similarity: Belongs to the NAB family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAB2_HUMAN, Q15742
    Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks
    repression ability (By similarity)
    Induction: By serum and phorbol myristate acetate (PMA) stimulation

         Genatlas biochemistry entry for NAB2:
    NGFI-A (nerve growth factor induced clone A) binding protein 2 (ERG2 binding protein) highly expressed in brain and
    thymus,with an alternatively splicing isoform missing exon 3,and in vascular smooth muscle cell in response to injury

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS8668170
    GO:0008134transcription factor binding IEA--
         
    NAB2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nab2):
     behavior/neurological  cellular  growth/size  integument  mortality/aging 
     nervous system  normal  reproductive system  respiratory system  skeleton 

    NAB2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Nab2tm1Jmi for NAB2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NAB2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NAB2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAB2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NAB2 (see all 23):
    hsa-miR-495 hsa-miR-137 hsa-miR-509-5p hsa-miR-650 hsa-miR-1184 hsa-miR-3154 hsa-miR-7-1* hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNAB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAB2 (see all 7)
    OriGene shRNA RFP: NAB2
    OriGene siRNA: NAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAB2
    Sirion Biotech Custom design and validation of potent shRNA sequences against NAB2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAB2
    Sirion Biotech Customized adenovirus for overexpression of NAB2 
    Sirion Biotech Customized adenovirus for potent knockdown of NAB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAB2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAB2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NAB2 (NM_005967)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAB2
    Search LifeMap BioReagents cell lines for NAB2
    Sirion Biotech Customized stable knockdown cell line services for NAB2 
    Sirion Biotech Customized inducible knockdown cell line services for NAB2
    Sirion Biotech Customized stable overexpressing cell line services for NAB2
    Sirion Biotech Customized inducible overexpressing cell line services for NAB2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NAB2
        Transcription factors in neurogenesis




    NAB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for NAB2 (Q157423 ENSP000003001314) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGR1P181463, ENSP000002399384I2D: score=4 STRING: ENSP00000239938
    EGR2P111613, ENSP000002424804I2D: score=2 STRING: ENSP00000242480
    CHD4Q148393, ENSP000003495084I2D: score=2 STRING: ENSP00000349508
    CHD3Q128733, ENSP000003697164I2D: score=1 STRING: ENSP00000369716
    NEDD9Q145113I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001958endochondral ossification IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development TAS8668170
    GO:0008283cell proliferation TAS8668170

    NAB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAB2
    2 Novoseek chemical compound relationships for NAB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 31.7 1 9722618 (1)
    vegf 22 3 17549302 (1), 11327726 (1), 17641395 (1)

    Search CenterWatch for drugs/clinical trials and news about NAB2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAB2 gene: 
    NM_005967.3  

    Unigene Cluster for NAB2:

    NGFI-A binding protein 2 (EGR1 binding protein 2)
    Hs.159223  [show with all ESTs]
    Unigene Representative Sequence: NM_005967
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300131(uc001smz.3) ENST00000555857 ENST00000342556 ENST00000554718
    ENST00000554839 ENST00000357680

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NAB2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAB2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NAB2 (see all 23):
    hsa-miR-495 hsa-miR-137 hsa-miR-509-5p hsa-miR-650 hsa-miR-1184 hsa-miR-3154 hsa-miR-7-1* hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNAB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAB2 (see all 7)
    OriGene shRNA RFP: NAB2
    OriGene siRNA: NAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAB2
    Sirion Biotech Custom design and validation of potent shRNA sequences against NAB2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAB2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAB2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NAB2 (NM_005967)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAB2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAB2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAB2

    Additional cDNA sequence: 

    AK314229.1 BC065931.1 U48361.1 X70991.1 

    12 DOTS entries:

    DT.92021908  DT.97846322  DT.448512  DT.97767371  DT.75172958  DT.100797695  DT.121175392  DT.92455131 
    DT.95371077  DT.95371081  DT.95220306  DT.95337045 

    24/73 AceView cDNA sequences (see all 73):

    CR622165 NM_005967 BQ059284 BQ424118 U48361 BM552661 BM559519 AU133683 
    BI767607 BC065931 BQ422441 BQ956141 BM928408 BM835228 BM558623 BC007756 
    BM545671 BF343338 BM473478 BM809254 BM911943 BF525913 BX416458 BQ068461 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NAB2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                          -                                             
    SP2:                          -                             -               
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for NAB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCATAAGAC
    NAB2 Expression
    About this image
    See NAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAB2

    SOURCE GeneReport for Unigene cluster: Hs.159223

    UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742
    Tissue specificity: Widely expressed at low levels. Highly expressed in melanoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including NAB2: 
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAB2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NAB2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nab21 , 5 Ngfi-A binding protein 21, 5 89.14(n)1
    95.62(a)1
      10 (74.60 cM)5
    179371  NM_008668.21  NP_032694.21 
     1276609185 
    lizard
    (Anolis carolinensis)
    Reptilia NAB26
    --
    66(a)
    1 ↔ 1
    GL343212.1(2650495-2667479)
    zebrafish
    (Danio rerio)
    Actinopterygii nab21 NGFI-A binding protein 2 (EGR1 binding protein 2) 57.87(n)
    55.26(a)
      100005680  NM_001114482.1  NP_001107954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nab6
    nab
    23(a)
    1 → many
    3L(4153618-4160932)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-106
    Male ABnormal family member (mab-10)
    19(a)
    1 → many
    II(10530349-10533446)


    ENSEMBL Gene Tree for NAB2 (if available)
    TreeFam Gene Tree for NAB2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAB2 gene
    NAB12  
    1 SIMAP similar gene for NAB2 using alignment to 1 protein entry:     NAB2_HUMAN:
    NAB1

    NAB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in NAB2 are shown (see all 163    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899152481,2
    --57480698(+) ACAATG/TTAGAG 1 -- us2k10--------
    rs762311811,2
    C,F--57480782(+) CGGTAG/ATTTCA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1416571441,2
    --57480844(+) GGGCAA/GGCCCC 1 -- us2k10--------
    rs1505387571,2
    --57480846(+) GCAGGC/TCCCTT 1 -- us2k10--------
    rs37591351,2
    C,F--57480977(+) CGGGCG/TCCCCG 1 -- us2k12Minor allele frequency- T:0.10NA EA 240
    rs1820764601,2
    --57481405(+) CAACTG/TAAATC 1 -- us2k10--------
    rs798615891,2
    F--57481472(+) CGCTAG/AGCCAC 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs37591361,2
    C,F,H--57481494(+) AGCCCC/TGGTCC 1 -- us2k16Minor allele frequency- T:0.03EA NS NA 2000
    rs1146556911,2
    C,F--57481636(+) CCCCCC/GCTCCT 1 -- us2k11Minor allele frequency- G:0.16WA 118
    rs1394579101,2
    --57481924(+) ATCGTC/GTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAB2 (57482677 - 57489259 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NAB2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAB2
    DNA2.0 Custom Variant and Variant Library Synthesis for NAB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NAB2 for disorders           About GeneDecksing

    OMIM gene information: 602381    OMIM disorders: --

    20 diseases for NAB2:    About MalaCards
    charcot-marie-tooth disease type 3    charcot-marie-tooth disease    melanoma    peripheral neuropathy
    dilated cardiomyopathy    tooth disease    bipolar disorder    neuropathy
    prostate carcinoma    cardiomyopathy    hepatitis b    scleroderma
    prostate cancer    fibrosarcoma    prostatitis    meningioma
    hepatitis    carcinoma    cervicitis    leukemia

    3 Novoseek disease relationships for NAB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 40.3 4 11567222 (3), 16956712 (1)
    prostate cancer 20.5 1 11567222 (1)
    tumors 0 6 16552752 (1), 11567222 (1), 17207284 (1)

    Human Genome Epidemiology (HuGE) Navigator: NAB2 (8 documents)

    Export disorders for NAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAB2 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with NAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PubMed id 8668170)1, 2, 3, 9 Svaren J....Milbrandt J. (1996)
    2. Mader: a novel nuclear protein over expressed in human melanomas. (PubMed id 8649813)1, 2, 3 Kirsch K.H....Johnson J.P. (1996)
    3. The Nab2 and Stat6 genes share a common transcription termination region. (PubMed id 9126479)1, 2, 9 Svaren J.... Milbrandt J. (1997)
    4. The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. (PubMed id 21836637)1, 2 Garcia-Gutierrez P.... Garcia-Dominguez M. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PubMed id 16574654)1, 9 Srinivasan R....Svaren J. (2006)
    7. Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PubMed id 12030330)1, 9 Venken K....Svaren J. (2002)
    8. Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. (PubMed id 11567222)1, 9 Abdulkadir S.A....Milbrandt J. (2001)
    9. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. (PubMed id 9722618)1, 9 Qu Z....Milbrandt J. (1998)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4665 HGNC: 7627 AceView: NAB2 Ensembl:ENSG00000166886 euGenes: HUgn4665
    ECgene: NAB2 H-InvDB: NAB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAB2 gene:
    Search GeneIP for patents involving NAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NAB2
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NAB2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAB2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAB2  
     OriGene Protein Over-expression Lysate for NAB2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NAB2   OriGene 3'-UTR Clone for NAB2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAB2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAB2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NAB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NAB2   OriGene Custom Protein Services for NAB2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAB2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAB2
     GenScript Custom Purified and Recombinant Proteins Services for NAB2 GenScript cDNA clones with any tag delivered in your preferred vector for NAB2
     GenScript Custom Assay Services for NAB2 GenScript Custom Superior Antibodies Services for NAB2
     GenScript Custom overexpressing Cell Line Services for NAB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NAB2 promoter
     Search Chromatin IP Primers for NAB2
     RT2 qPCR Primer Assay in human, mouse, rat NAB2
     GNC Network for NAB2
     SABiosciences PCR Arrays including human, mouse, rat NAB2
     Search Tocris compounds for NAB2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NAB2 antibodies
     NAB2 proteins
     NAB2 lysates
     Antibodies for NAB2
     See all of Abcam's Antibodies, Kits and Proteins for NAB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NAB2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NAB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB2
     SwitchGear 3'UTR luciferase reporter plasmids for NAB2
     SwitchGear Promoter luciferase reporter plasmids for NAB2
     ThermoFisher Antibodies for NAB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAB2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NAB2
    Sirion Biotech Customized:
     stable knockdown cell line services for NAB2
     inducible knockdown cell line services for NAB2
     design and validation of potent shRNA sequences against NAB2
     adenovirus for potent knockdown of NAB2
     adenovirus for overexpression of NAB2
     stable overexpressing cell line services for NAB2
     inducible overexpressing cell line services for NAB2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NAB2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4