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Aliases for NAB2 Gene

Aliases for NAB2 Gene

  • NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) 2 3
  • Melanoma-Associated Delayed Early Response Protein 3 4
  • EGR-1-Binding Protein 2 3 4
  • MADER 3 4
  • NGFI-A-Binding Protein 2 3
  • EGR1 Binding Protein 2 3
  • Protein MADER 4

External Ids for NAB2 Gene

Previous GeneCards Identifiers for NAB2 Gene

  • GC12P057457
  • GC12P057707
  • GC12P057199
  • GC12P055769
  • GC12P054521

Summaries for NAB2 Gene

Entrez Gene Summary for NAB2 Gene

  • This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAB2 Gene

NAB2 (NGFI-A Binding Protein 2 (EGR1 Binding Protein 2)) is a Protein Coding gene. Diseases associated with NAB2 include hemangiopericytoma and melanoma. GO annotations related to this gene include transcription factor binding and transcription corepressor activity. An important paralog of this gene is NAB1.

UniProtKB/Swiss-Prot for NAB2 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Gene Wiki entry for NAB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAB2 Gene

Genomics for NAB2 Gene

Regulatory Elements for NAB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAB2 Gene

Start:
57,088,894 bp from pter
End:
57,095,476 bp from pter
Size:
6,583 bases
Orientation:
Plus strand

Genomic View for NAB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAB2 Gene

Proteins for NAB2 Gene

  • Protein details for NAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15742-NAB2_HUMAN
    Recommended name:
    NGFI-A-binding protein 2
    Protein Accession:
    Q15742
    Secondary Accessions:
    • B2RAK3
    • O76006
    • Q14797

    Protein attributes for NAB2 Gene

    Size:
    525 amino acids
    Molecular mass:
    56594 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Alternative splice isoforms for NAB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB2 Gene

Proteomics data for NAB2 Gene at MOPED

Post-translational modifications for NAB2 Gene

  • Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NAB2 Gene

Domains for NAB2 Gene

Protein Domains for NAB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15742

UniProtKB/Swiss-Prot:

NAB2_HUMAN :
  • Q15742
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression
Family:
  • Belongs to the NAB family.
genes like me logo Genes that share domains with NAB2: view

No data available for Gene Families for NAB2 Gene

Function for NAB2 Gene

Molecular function for NAB2 Gene

GENATLAS Biochemistry:
NGFI-A (nerve growth factor induced clone A) binding protein 2 (ERG2 binding protein) highly expressed in brain and thymus,with an alternatively splicing isoform missing exon 3,and in vascular smooth muscle cell in response to injury
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
UniProtKB/Swiss-Prot Induction:
By serum and phorbol myristate acetate (PMA) stimulation

Gene Ontology (GO) - Molecular Function for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 8668170
GO:0005515 protein binding IPI 21516116
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with NAB2: view
genes like me logo Genes that share phenotypes with NAB2: view

Animal Models for NAB2 Gene

MGI Knock Outs for NAB2:

Animal Model Products

miRNA for NAB2 Gene

miRTarBase miRNAs that target NAB2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NAB2 Gene

Localization for NAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB2 Gene

Nucleus. Note=Isoform 2 is not localized to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAB2 Gene COMPARTMENTS Subcellular localization image for NAB2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NAB2: view

Pathways for NAB2 Gene

SuperPathways for NAB2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007399 nervous system development TAS 8668170
GO:0008283 cell proliferation TAS 8668170
genes like me logo Genes that share ontologies with NAB2: view

No data available for Pathways by source for NAB2 Gene

Compounds for NAB2 Gene

(2) Novoseek inferred chemical compound relationships for NAB2 Gene

Compound -log(P) Hits PubMed IDs
zinc 31.7 1
vegf 22 3
genes like me logo Genes that share compounds with NAB2: view

Transcripts for NAB2 Gene

Unigene Clusters for NAB2 Gene

NGFI-A binding protein 2 (EGR1 binding protein 2):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAB2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for NAB2 Gene

GeneLoc Exon Structure for
NAB2
ECgene alternative splicing isoforms for
NAB2

Expression for NAB2 Gene

mRNA expression in normal human tissues for NAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NAB2 Gene

This gene is overexpressed in Lung (19.6), Placenta (18.9), NK cells (16.3), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAB2 Gene

SOURCE GeneReport for Unigene cluster for NAB2 Gene Hs.159223

mRNA Expression by UniProt/SwissProt for NAB2 Gene

Q15742-NAB2_HUMAN
Tissue specificity: Widely expressed at low levels. Highly expressed in melanoma cell lines
genes like me logo Genes that share expressions with NAB2: view

Expression partners for NAB2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NAB2 Gene

Orthologs for NAB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAB2 35
  • 93.52 (n)
  • 98.29 (a)
NAB2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAB2 35
  • 92.7 (n)
  • 98.1 (a)
NAB2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nab2 35
  • 89.14 (n)
  • 95.62 (a)
Nab2 16
Nab2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAB2 35
  • 99.81 (n)
  • 100 (a)
NAB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nab2 35
  • 89.97 (n)
  • 96.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NAB2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAB2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nab2 35
  • 60.93 (n)
  • 61 (a)
zebrafish
(Danio rerio)
Actinopterygii nab2 35
  • 56.68 (n)
  • 54.38 (a)
nab2 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nab 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-10 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6864 36
  • 35 (a)
OneToMany
Species with no ortholog for NAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB2 Gene

ENSEMBL:
Gene Tree for NAB2 (if available)
TreeFam:
Gene Tree for NAB2 (if available)

Paralogs for NAB2 Gene

Paralogs for NAB2 Gene

Selected SIMAP similar genes for NAB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAB2: view

Variants for NAB2 Gene

Sequence variations from dbSNP and Humsavar for NAB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs324010 -- 57,088,469(-) CTTCT(C/T)CTGTG upstream-variant-2KB
rs324017 -- 57,094,031(-) CCGCC(G/T)GCCCA intron-variant
rs324018 -- 57,093,946(-) CCCAT(A/C)CCCAC intron-variant
rs324019 -- 57,092,864(-) TCGAC(C/T)GGCAG intron-variant
rs324020 -- 57,092,250(+) GGAGG(A/C)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAB2 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV Gain 17160897

Relevant External Links for NAB2 Gene

HapMap Linkage Disequilibrium report
NAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAB2 Gene

Disorders for NAB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NAB2 Gene in MalaCards »

(2) Diseases for NAB2 Gene including...

(3) Novoseek inferred disease relationships for NAB2 Gene

Disease -log(P) Hits PubMed IDs
prostate carcinoma 40.3 4
prostate cancer 20.5 1
tumors 0 3

Relevant External Links for NAB2

Genetic Association Database (GAD)
NAB2
Human Genome Epidemiology (HuGE) Navigator
NAB2
genes like me logo Genes that share disorders with NAB2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NAB2 Gene

Publications for NAB2 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J. … Milbrandt J. (Mol. Cell. Biol. 1996) 2 3 4 23
  2. The Nab2 and Stat6 genes share a common transcription termination region. (PMID: 9126479) Svaren J. … Milbrandt J. (Genomics 1997) 3 4 23
  3. Mader: a novel nuclear protein over expressed in human melanomas. (PMID: 8649813) Kirsch K.H. … Johnson J.P. (Oncogene 1996) 2 3 4
  4. Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PMID: 12030330) Venken K. … Svaren J. (Neurogenetics 2002) 3 23
  5. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. (PMID: 9722618) Qu Z. … Milbrandt J. (J. Cell Biol. 1998) 3 23

Products for NAB2 Gene

Sources for NAB2 Gene

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