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Aliases & Descriptions for NAB2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MADER 1, 2, 3 | | MGC75085 2 |
| | | Descriptions |
|---|
| EGR-1-binding protein 2 3 | | EGR1 binding protein 2 2 | | Melanoma-associated delayed early response protein 2, 3 | | NGFI-A binding protein 2 2 | | NGFI-A binding protein 2 (EGR1 binding protein 2) 2 | | Protein MADER 3 |
|
| | Search outside databases for aliases for NAB2 genePrevious GC identifers: GC12P057457 GC12P057707 GC12P057199 |
Summaries for NAB2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAB2: This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)Gene Wiki entry for NAB2 |
Genomic Location for NAB2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAB2 gene 
Entrez Gene cytogenetic band: 12q13.3-q14.1 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3NAB2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P055769:
(about GC identifiers)
Start:
|
55,768,944 bp from pter |
End:
|
55,775,526 bp from pter |
Size:
|
6,583 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for NAB2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742 (See
protein sequence)Recommended Name: NGFI-A-binding protein 2 Size: 525 amino acids; 56594 Da
Subunit: Homomultimers may associate with EGR1 bound to DNA (By similarity)
Subcellular location: Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity)
Secondary accessions: O76006 Q14797Alternative splicing: 3 isoforms: Q15742-1 Q15742-2 Q15742-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005958.1
ENSEMBL proteins: ENSP00000377439 ENSP00000350309 ENSP00000341491 ENSP00000300131
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NAB2 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for NAB2: Assays for NAB2: | Protein
Domains/ Families for NAB2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15742
ProtoNet protein and cluster: Q15742 UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742Domain: The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerizationDomain: The NAB conserved domain 2 (NCD2) is necessary for transcriptional repressionSimilarity: Belongs to the NAB family | Gene Function for NAB2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005967
Applied Biosystems Silencer® siRNAs for NAB2
Sigma-Aldrich siRNA for NAB2  Sigma-Aldrich shRNA for NAB2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005967                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005967                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005967 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005967
UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)Induction: By serum and PMA stimulationGenatlas biochemistry entry for NAB2:NGFI-A (nerve growth factor induced clone A) binding protein 2 (ERG2 binding protein) highly expressed in brain and thymus,with an alternatively splicing isoform missing exon 3,and in vascular smooth muscle cell in response to injury10 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nab2):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003714 | transcription corepressor activity |
TAS | 8668170 | About this table | Pathways & Interactions for NAB2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for NAB2 
5 Interacting proteins for NAB2 (ENSP000003001313) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for NAB2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAB2 1 Novoseek chemical compound relationship for NAB2 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
27.41 |
1 |
9722618 (1) |
About this table
|
Transcripts for NAB2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005967
Sigma-Aldrich siRNA for NAB2  Sigma-Aldrich shRNA for NAB2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005967 REFSEQ mRNAs for NAB2 gene: NM_005967.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005967               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005967                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005967                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005967  Additional cDNA sequence: AK314229.1 BC065931.1 CR603613.1 CR622165.1 U48361.1 X70991.1 12 DOTS entries: DT.92021908 DT.97846322 DT.97767371 DT.448512 DT.75172958 DT.100797695 DT.121175392 DT.92455131 DT.95371077 DT.95371081 DT.95220306 DT.95337045 24/73 AceView cDNA sequences (see all 73
):BQ424118 BC007756 U48361 BM835228 BQ422441 NM_005967 BM552661 BC065931 BQ059284 BM559519 CR622165 BI767607 BQ956141 BM928408 BM558623 AU133683 AW163064 BM545671 BG678380 BF525913 BM810231 BG476950 CD621461 BX414813
highest scoring ESTs for NAB2:X70991 AA195032 AA242793 AA252180 AA333002 AA378071 AA434391 AA631087 AA670443 AA725011 Unigene Cluster for NAB2: NGFI-A binding protein 2 (EGR1 binding protein 2) Hs.159223 [show with all ESTs]Unigene Representative Sequence: NM_005967
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NAB2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAB2
4 Ensembl transcripts including schematic representations: ENST00000393858
ENST00000357680
ENST00000342556
ENST00000300131
|
Expression for NAB2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAB2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAB2
1 / 2 / 3 5 probe-sets matching NAB2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGCATAAGAC
SOURCE GeneReport for Unigene cluster: Hs.159223
Expression variation in blood from EXPOLDB for NAB2 UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742Tissue specificity: Widely expressed at low levels. Highly expressed in melanoma cell lines |
Orthologs for NAB2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAB2 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for NAB2
ENSEMBL Gene Tree for NAB2 | Paralogs for NAB2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAB2 gene
- NAB12
|
SNPs/Variants for NAB2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAB2 (up to first 250kb)
|
Disorders & Mutations for NAB2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602381
3 Novoseek disease relationships for NAB2 gene
About this table
|
Medical News for NAB2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAB2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/42 PubMed articles for NAB2 gene (see all 42
):- NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PubMed id 8668170)1, 2, 3, 4 Svaren J....Milbrandt J. (1996)
- Mader: a novel nuclear protein over expressed in human melanomas. (PubMed id 8649813)2, 3, 4 Kirsch K.H....Johnson J.P. (1996)
- The Nab2 and Stat6 genes share a common transcription termination region. (PubMed id 9126479)1, 3, 4 Svaren J.... Milbrandt J. (1997)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PubMed id 16574654)1, 3 Srinivasan R....Svaren J. (2006)
- Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PubMed id 12030330)1, 3 Venken K....Svaren J. (2002)
- Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. (PubMed id 11567222)1, 3 Abdulkadir S.A....Milbrandt J. (2001)
- The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. (PubMed id 9722618)1, 3 Qu Z....Milbrandt J. (1998)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
|
Search for NAB2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAB2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAB2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAB2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAB2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAB2:

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