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Aliases for NAB2 Gene

Aliases for NAB2 Gene

  • NGFI-A Binding Protein 2 2 3 5
  • Melanoma-Associated Delayed Early Response Protein 3 4
  • EGR1 Binding Protein 2 2 3
  • MADER 3 4
  • NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) 2
  • NGFI-A-Binding Protein 2 3
  • EGR-1-Binding Protein 2 4
  • Protein MADER 4

External Ids for NAB2 Gene

Previous GeneCards Identifiers for NAB2 Gene

  • GC12P057457
  • GC12P057707
  • GC12P057199
  • GC12P055769
  • GC12P054521

Summaries for NAB2 Gene

Entrez Gene Summary for NAB2 Gene

  • This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAB2 Gene

NAB2 (NGFI-A Binding Protein 2) is a Protein Coding gene. Diseases associated with NAB2 include Hemangiopericytoma, Malignant and Melanoma. Gene Ontology (GO) annotations related to this gene include transcription factor binding and transcription corepressor activity. An important paralog of this gene is NAB1.

UniProtKB/Swiss-Prot for NAB2 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Gene Wiki entry for NAB2 Gene

Additional gene information for NAB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAB2 Gene

Genomics for NAB2 Gene

GeneHancer (GH) Regulatory Elements for NAB2 Gene

Promoters and enhancers for NAB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057085 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +3.2 3173 14.1 CLOCK MLX YBX1 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NAB2 RPL41 STAT6 R3HDM2 NEMP1 INHBE GC12P057094 GC12P057095
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 80.5 +22.4 22360 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.2 -866.0 -866012 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I056266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.2 -821.7 -821700 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 COQ10A GC12M056238 NEMP1 PAN2 BAZ2A PHC1P1 ANKRD52 DNAJC14 SMARCC2 RN7SL809P
GH12I056187 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.3 -899.4 -899438 3.5 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZNF610 ENSG00000258199 SMARCC2 GC12P056192 TRS-CGA4-1 NEMP1 ENSG00000257740 IKZF4 ANKRD52 PHC1P1 BAZ2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAB2 gene promoter:

Genomic Locations for NAB2 Gene

Genomic Locations for NAB2 Gene
chr12:57,088,894-57,095,476
(GRCh38/hg38)
Size:
6,583 bases
Orientation:
Plus strand
chr12:57,482,677-57,489,259
(GRCh37/hg19)

Genomic View for NAB2 Gene

Genes around NAB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAB2 Gene

Proteins for NAB2 Gene

  • Protein details for NAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15742-NAB2_HUMAN
    Recommended name:
    NGFI-A-binding protein 2
    Protein Accession:
    Q15742
    Secondary Accessions:
    • B2RAK3
    • O76006
    • Q14797

    Protein attributes for NAB2 Gene

    Size:
    525 amino acids
    Molecular mass:
    56594 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Alternative splice isoforms for NAB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB2 Gene

Post-translational modifications for NAB2 Gene

  • Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.

Other Protein References for NAB2 Gene

No data available for DME Specific Peptides for NAB2 Gene

Domains & Families for NAB2 Gene

Gene Families for NAB2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15742

UniProtKB/Swiss-Prot:

NAB2_HUMAN :
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • Belongs to the NAB family.
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Family:
  • Belongs to the NAB family.
genes like me logo Genes that share domains with NAB2: view

Function for NAB2 Gene

Molecular function for NAB2 Gene

GENATLAS Biochemistry:
NGFI-A (nerve growth factor induced clone A) binding protein 2 (ERG2 binding protein) highly expressed in brain and thymus,with an alternatively splicing isoform missing exon 3,and in vascular smooth muscle cell in response to injury
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
UniProtKB/Swiss-Prot Induction:
By serum and phorbol myristate acetate (PMA) stimulation.

Phenotypes From GWAS Catalog for NAB2 Gene

Gene Ontology (GO) - Molecular Function for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 8668170
GO:0005515 protein binding IPI 21516116
GO:0008134 transcription factor binding IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with NAB2: view
genes like me logo Genes that share phenotypes with NAB2: view

Animal Models for NAB2 Gene

MGI Knock Outs for NAB2:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAB2 Gene

Localization for NAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB2 Gene

Nucleus. Note=Isoform 2 is not localized to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAB2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NAB2: view

Pathways & Interactions for NAB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development TAS 8668170
GO:0008283 cell proliferation TAS 8668170
genes like me logo Genes that share ontologies with NAB2: view

No data available for Pathways by source and SIGNOR curated interactions for NAB2 Gene

Drugs & Compounds for NAB2 Gene

(1) Drugs for NAB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NAB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAB2: view

Transcripts for NAB2 Gene

Unigene Clusters for NAB2 Gene

NGFI-A binding protein 2 (EGR1 binding protein 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAB2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for NAB2 Gene

GeneLoc Exon Structure for
NAB2
ECgene alternative splicing isoforms for
NAB2

Expression for NAB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAB2 Gene

This gene is overexpressed in Lung (19.6), Placenta (18.9), NK cells (16.3), and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAB2 Gene



Protein tissue co-expression partners for NAB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAB2 Gene:

NAB2

SOURCE GeneReport for Unigene cluster for NAB2 Gene:

Hs.159223

mRNA Expression by UniProt/SwissProt for NAB2 Gene:

Q15742-NAB2_HUMAN
Tissue specificity: Widely expressed at low levels. Highly expressed in melanoma cell lines.

Evidence on tissue expression from TISSUES for NAB2 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(3.7)
  • Pancreas(2.6)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NAB2 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Organs:
Head and neck:
  • ear
Thorax:
  • heart
General:
  • blood
  • blood vessel
genes like me logo Genes that share expression patterns with NAB2: view

Primer Products

No data available for mRNA differential expression in normal tissues for NAB2 Gene

Orthologs for NAB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAB2 33 34
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia NAB2 33 34
  • 93.52 (n)
oppossum
(Monodelphis domestica)
Mammalia NAB2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAB2 33 34
  • 92.7 (n)
rat
(Rattus norvegicus)
Mammalia Nab2 33
  • 89.97 (n)
mouse
(Mus musculus)
Mammalia Nab2 33 16 34
  • 89.14 (n)
lizard
(Anolis carolinensis)
Reptilia NAB2 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nab2 33
  • 60.93 (n)
zebrafish
(Danio rerio)
Actinopterygii nab2 33 34
  • 56.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta nab 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-10 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6864 34
  • 35 (a)
OneToMany
Species where no ortholog for NAB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB2 Gene

ENSEMBL:
Gene Tree for NAB2 (if available)
TreeFam:
Gene Tree for NAB2 (if available)

Paralogs for NAB2 Gene

Paralogs for NAB2 Gene

(1) SIMAP similar genes for NAB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAB2: view

Variants for NAB2 Gene

Sequence variations from dbSNP and Humsavar for NAB2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001081235 -- 57,092,089(+) T/C intron_variant
rs1001399236 -- 57,087,109(+) C/T upstream_transcript_variant
rs1001627481 -- 57,094,514(+) C/T intron_variant
rs1001796467 -- 57,095,300(+) G/A 3_prime_UTR_variant
rs1001912456 -- 57,095,558(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAB2 Gene

Variant ID Type Subtype PubMed ID
nsv1070533 CNV deletion 25765185
nsv482992 CNV gain+loss 15286789
nsv832428 CNV gain 17160897

Variation tolerance for NAB2 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAB2 Gene

Disorders for NAB2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NAB2 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hemangiopericytoma, malignant
  • hemangiopericytoma
melanoma
  • malignant melanoma
meninges hemangiopericytoma
  • hemangiopericytoma of meninges
- elite association - COSMIC cancer census association via MalaCards
Search NAB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAB2 Gene

Publications for NAB2 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J … Milbrandt J (Molecular and cellular biology 1996) 2 3 4 22 58
  2. The Nab2 and Stat6 genes share a common transcription termination region. (PMID: 9126479) Svaren J … Milbrandt J (Genomics 1997) 3 4 22 58
  3. Mader: a novel nuclear protein over expressed in human melanomas. (PMID: 8649813) Kirsch KH … Johnson JP (Oncogene 1996) 2 3 4 58
  4. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PMID: 22075330) Granada M … O'Connor GT (The Journal of allergy and clinical immunology 2012) 3 44 58
  5. The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. (PMID: 21836637) García-Gutiérrez P … García-Domínguez M (EMBO reports 2011) 3 4 58

Products for NAB2 Gene

Sources for NAB2 Gene

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