Aliases for NAB2 Gene
External Ids for NAB2 Gene
Previous GeneCards Identifiers for NAB2 Gene
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAB2 Gene
NAB2 (NGFI-A Binding Protein 2 (EGR1 Binding Protein 2)) is a Protein Coding gene. Diseases associated with NAB2 include hemangiopericytoma and melanoma. GO annotations related to this gene include transcription factor binding and transcription corepressor activity. An important paralog of this gene is NAB1.
UniProtKB/Swiss-Prot for NAB2 Gene
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).