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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAB2 Gene

protein-coding   GIFtS: 56
GCID: GC12P057457

NGFI-A Binding Protein 2 (EGR1 Binding Protein 2)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NGFI-A Binding Protein 2 (EGR1 Binding Protein 2)1 2     EGR1 Binding Protein 22
Melanoma-Associated Delayed Early Response Protein2 3     NGFI-A-Binding Protein 22
MADER2 3     Protein MADER3
EGR-1-Binding Protein 22 3     

External Ids:    HGNC: 76271   Entrez Gene: 46652   Ensembl: ENSG000001668867   OMIM: 6023815   UniProtKB: Q157423   

Export aliases for NAB2 gene to outside databases

Previous GC identifers: GC12P057707 GC12P057199 GC12P055769 GC12P054521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAB2 Gene:
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to
repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB
proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain,
and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the
encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex.
Alternatively spliced transcript variants have been described, but their biological validity has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAB2 Gene: 
NAB2 (NGFI-A binding protein 2 (EGR1 binding protein 2)) is a protein-coding gene. Diseases associated with NAB2 include melanoma, and tooth disease. GO annotations related to this gene include transcription corepressor activity and transcription factor binding. An important paralog of this gene is NAB1.

UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742
Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks
repression ability (By similarity)

Gene Wiki entry for NAB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAB2 gene promoter:
         Oct-B1   Elk-1   oct-B3   oct-B2   Pax-5   PPAR-gamma1   POU2F1   POU2F1a   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

NAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057457:  view genomic region     (about GC identifiers)

Start:
57,482,677 bp from pter      End:
57,489,259 bp from pter
Size:
6,583 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742 (See protein sequence)
Recommended Name: NGFI-A-binding protein 2  
Size: 525 amino acids; 56594 Da
Subunit: Homomultimers may associate with EGR1 bound to DNA (By similarity)
Subcellular location: Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity)
Secondary accessions: B2RAK3 O76006 Q14797
Alternative splicing: 3 isoforms:  Q15742-1   Q15742-2   Q15742-3   

Explore the universe of human proteins at neXtProt for NAB2: NX_Q15742

Explore proteomics data for NAB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15742

  • NAB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAB2 Protein Expression
    REFSEQ proteins: NP_005958.1  
    ENSEMBL proteins: 
     ENSP00000300131   ENSP00000341491   ENSP00000350309  

    Human Recombinant Protein Products for NAB2: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NAB2
    OriGene Protein Over-expression Lysate for NAB2
    OriGene MassSpec for NAB2 
    OriGene Custom Protein Services for NAB2
    GenScript Custom Purified and Recombinant Proteins Services for NAB2
    Novus Biologicals NAB2 Proteins
    Novus Biologicals NAB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NAB2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NAB2 for ontologies           About GeneDecksing



    NAB2 Antibody Products: 
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    Abcam antibodies for NAB2
    Cloud-Clone Corp. Antibodies for NAB2 
    ThermoFisher Antibodies for NAB2
    LSBio Antibodies in human, mouse, rat for NAB2 

    Assay Products for NAB2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAB2 
    Cloud-Clone Corp. CLIAs for NAB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006988 Nab_N
     IPR006989 NAB_co-repressor_dom

    Graphical View of Domain Structure for InterPro Entry Q15742

    ProtoNet protein and cluster: Q15742

    UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742
    Domain: The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization
    Domain: The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression
    Similarity: Belongs to the NAB family


    NAB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAB2_HUMAN, Q15742
    Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks
    repression ability (By similarity)
    Induction: By serum and phorbol myristate acetate (PMA) stimulation

         Genatlas biochemistry entry for NAB2:
    NGFI-A (nerve growth factor induced clone A) binding protein 2 (ERG2 binding protein) highly expressed in brain
    and thymus,with an alternatively splicing isoform missing exon 3,and in vascular smooth muscle cell in response
    to injury

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS8668170
    GO:0008134transcription factor binding IEA--
         
    NAB2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nab2):
     behavior/neurological  cellular  growth/size  integument  mortality/aging 
     nervous system  normal  reproductive system  respiratory system  skeleton 

    NAB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nab2tm1Jmi for NAB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAB2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAB2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NAB2 (see all 23):
    hsa-miR-495 hsa-miR-137 hsa-miR-509-5p hsa-miR-650 hsa-miR-1184 hsa-miR-3154 hsa-miR-7-1* hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNAB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAB2

    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAB2
    Sirion Biotech Customized lentivirus for stable overexpression of NAB2 
                         Customized lentivirus expression plasmids for stable overexpression of NAB2 

    Cell Line
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    Search LifeMap BioReagents cell lines for NAB2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NAB2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NAB2
        Transcription factors in neurogenesis





    NAB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for NAB2 (Q157423 ENSP000003001314) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGR1P181463, ENSP000002399384I2D: score=4 STRING: ENSP00000239938
    EGR2P111613, ENSP000002424804I2D: score=2 STRING: ENSP00000242480
    CHD4Q148393, ENSP000003495084I2D: score=2 STRING: ENSP00000349508
    CHD3Q128733, ENSP000003697164I2D: score=1 STRING: ENSP00000369716
    NEDD9Q145113I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001958endochondral ossification IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development TAS8668170
    GO:0008283cell proliferation TAS8668170

    NAB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAB2

    2 Novoseek inferred chemical compound relationships for NAB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 31.7 1 9722618 (1)
    vegf 22 3 17549302 (1), 11327726 (1), 17641395 (1)

    Search CenterWatch for drugs/clinical trials and news about NAB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAB2 gene: 
    NM_005967.3  

    Unigene Cluster for NAB2:

    NGFI-A binding protein 2 (EGR1 binding protein 2)
    Hs.159223  [show with all ESTs]
    Unigene Representative Sequence: NM_005967
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300131(uc001smz.3) ENST00000555857 ENST00000342556 ENST00000554718
    ENST00000554839 ENST00000357680
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAB2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NAB2 (see all 23):
    hsa-miR-495 hsa-miR-137 hsa-miR-509-5p hsa-miR-650 hsa-miR-1184 hsa-miR-3154 hsa-miR-7-1* hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNAB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAB2
    Clone
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    OriGene clones in human, mouse for NAB2 (see all 9)
    OriGene ORF clones in mouse, rat for NAB2
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAB2
    Sirion Biotech Customized lentivirus for stable overexpression of NAB2 
                         Customized lentivirus expression plasmids for stable overexpression of NAB2 
    Primer
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    OriGene qPCR primer pairs and template standards for NAB2
    OriGene qSTAR qPCR primer pairs in human, mouse for NAB2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAB2

    Additional mRNA sequence: 

    AK314229.1 BC065931.1 U48361.1 X70991.1 

    12 DOTS entries:

    DT.92021908  DT.97846322  DT.448512  DT.97767371  DT.75172958  DT.100797695  DT.121175392  DT.92455131 
    DT.95371077  DT.95371081  DT.95220306  DT.95337045 

    24/73 AceView cDNA sequences (see all 73):

    BC065931 BM559519 CR622165 BM552661 NM_005967 U48361 BQ424118 BQ422441 
    BI767607 BM928408 BM558623 BQ956141 AU133683 BC007756 BM835228 BQ059284 
    BM545671 BM713231 BX423901 BM810231 BU854919 AL589212 BF342406 BG334361 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NAB2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                          -                                             
    SP2:                          -                             -               
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for NAB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAB2 expression in normal human tissues (normalized intensities)      NAB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATAAGAC
    NAB2 Expression
    About this image


    NAB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Peripheral Nervous System (Nervous System)
             Myelinating Schwann Cells Peripheral Nerve Domain

    See NAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAB2

    SOURCE GeneReport for Unigene cluster: Hs.159223

    UniProtKB/Swiss-Prot: NAB2_HUMAN, Q15742
    Tissue specificity: Widely expressed at low levels. Highly expressed in melanoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including NAB2: 
              Estrogen Receptor Signaling in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NAB2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nab21 , 5 Ngfi-A binding protein 21, 5 89.14(n)1
    95.62(a)1
      10 (74.60 cM)5
    179371  NM_008668.21  NP_032694.21 
     1276609185 
    lizard
    (Anolis carolinensis)
    Reptilia NAB26
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343212.1(2645586-2667479)
    zebrafish
    (Danio rerio)
    Actinopterygii nab21 NGFI-A binding protein 2 (EGR1 binding protein 2) 57.87(n)
    55.26(a)
      100005680  NM_001114482.1  NP_001107954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nab6
    nab
    21(a)
    1 → many
    3L(4153618-4160932)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-106
    Protein MAB-10
    19(a)
    1 → many
    II(10530409-10533506)


    ENSEMBL Gene Tree for NAB2 (if available)
    TreeFam Gene Tree for NAB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAB2 gene
    NAB12  
    1 SIMAP similar gene for NAB2 using alignment to 1 protein entry:     NAB2_HUMAN:
    NAB1

    NAB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in NAB2 are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899152481,2
    --57480698(+) ACAATG/TTAGAG 1 -- us2k10--------
    rs762311811,2
    C,F--57480782(+) CGGTAG/ATTTCA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1416571441,2
    C--57480844(+) GGGCAA/GGCCCC 1 -- us2k10--------
    rs1505387571,2
    --57480846(+) GCAGGC/TCCCTT 1 -- us2k10--------
    rs37591351,2
    C,F--57480977(+) CGGGCG/TCCCCG 1 -- us2k12Minor allele frequency- T:0.10NA EA 240
    rs1820764601,2
    --57481405(+) CAACTG/TAAATC 1 -- us2k10--------
    rs798615891,2
    F--57481472(+) CGCTAG/AGCCAC 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs37591361,2
    C,F,H--57481494(+) AGCCCC/TGGTCC 1 -- us2k16Minor allele frequency- T:0.03EA NS NA 2000
    rs1146556911,2
    C,F--57481636(+) CCCCCC/G/TCTCCT 1 -- us2k11WA 118
    rs1394579101,2
    --57481924(+) ATCGTC/GTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAB2 (57482677 - 57489259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NAB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832428CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602381    OMIM disorders: --

    18 diseases for NAB2:    About MalaCards
    melanoma    tooth disease    charcot-marie-tooth disease    peripheral neuropathy
    scleroderma    dilated cardiomyopathy    bipolar disorder    fibrosarcoma
    meningioma    neuropathy    prostatitis    endotheliitis
    prostate cancer    hepatitis b    hepatitis    cervicitis
    leukemia    breast cancer


    NAB2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NAB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 40.3 4 11567222 (3), 16956712 (1)
    prostate cancer 20.5 1 11567222 (1)
    tumors 0 6 16552752 (1), 11567222 (1), 17207284 (1)

    Genetic Association Database (GAD): NAB2
    Human Genome Epidemiology (HuGE) Navigator: NAB2 (8 documents)

    Export disorders for NAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAB2 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with NAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PubMed id 8668170)1, 2, 3, 9 Svaren J....Milbrandt J. (1996)
    2. Mader: a novel nuclear protein over expressed in human melanomas. (PubMed id 8649813)1, 2, 3 Kirsch K.H....Johnson J.P. (1996)
    3. The Nab2 and Stat6 genes share a common transcription termination region. (PubMed id 9126479)1, 2, 9 Svaren J.... Milbrandt J. (1997)
    4. A genome-wide association study of plasma total IgE co ncentrations in the Framingham Heart Study. (PubMed id 22075330)1, 4 Granada M....O'Connor G.T. (2012)
    5. The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. (PubMed id 21836637)1, 2 Garcia-Gutierrez P.... Garcia-Dominguez M. (2011)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PubMed id 16574654)1, 9 Srinivasan R....Svaren J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4665 HGNC: 7627 AceView: NAB2 Ensembl:ENSG00000166886 euGenes: HUgn4665
    ECgene: NAB2 H-InvDB: NAB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAB2 gene:
    Search GeneIP for patents involving NAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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