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Aliases for NAB1 Gene

Aliases for NAB1 Gene

  • NGFI-A Binding Protein 1 (EGR1 Binding Protein 1) 2 3
  • Transcriptional Regulatory Protein P54 4
  • EGR-1-Binding Protein 1 4
  • EGR1 Binding Protein 1 2

External Ids for NAB1 Gene

Summaries for NAB1 Gene

GeneCards Summary for NAB1 Gene

NAB1 (NGFI-A Binding Protein 1 (EGR1 Binding Protein 1)) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is NAB2.

UniProtKB/Swiss-Prot for NAB1 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Gene Wiki entry for NAB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAB1 Gene

Genomics for NAB1 Gene

Genomic Location for NAB1 Gene

Start:
190,646,746 bp from pter
End:
190,692,766 bp from pter
Size:
46,021 bases
Orientation:
Plus strand

Genomic View for NAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAB1 Gene

Regulatory Elements for NAB1 Gene

Proteins for NAB1 Gene

  • Protein details for NAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13506-NAB1_HUMAN
    Recommended name:
    NGFI-A-binding protein 1
    Protein Accession:
    Q13506
    Secondary Accessions:
    • O75383
    • O75384
    • Q6GTU1
    • Q9UEV1

    Protein attributes for NAB1 Gene

    Size:
    487 amino acids
    Molecular mass:
    54401 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Three dimensional structures from OCA and Proteopedia for NAB1 Gene

    Alternative splice isoforms for NAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB1 Gene

Proteomics data for NAB1 Gene at MOPED

Post-translational modifications for NAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAB1 Gene

Domains for NAB1 Gene

Protein Domains for NAB1 Gene

Suggested Antigen Peptide Sequences for NAB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13506

UniProtKB/Swiss-Prot:

NAB1_HUMAN
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization:
    • Q13506
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression:
    • Q13506
Family:
  • Belongs to the NAB family.:
    • Q13506
genes like me logo Genes that share domains with NAB1: view

No data available for Gene Families for NAB1 Gene

Function for NAB1 Gene

Molecular function for NAB1 Gene

GENATLAS Biochemistry: NGFI-A (nerve growth factor induced clone A) binding protein 1 (EGR1 binding protein) also repressor of EGR2
UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Gene Ontology (GO) - Molecular Function for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with NAB1: view
genes like me logo Genes that share phenotypes with NAB1: view

Animal Models for NAB1 Gene

MGI Knock Outs for NAB1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NAB1 Gene

Localization for NAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAB1 Gene COMPARTMENTS Subcellular localization image for NAB1 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8668170
genes like me logo Genes that share ontologies with NAB1: view

Pathways for NAB1 Gene

genes like me logo Genes that share pathways with NAB1: view

Pathways by source for NAB1 Gene

1 BioSystems pathway for NAB1 Gene

Gene Ontology (GO) - Biological Process for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8668170
GO:0014037 Schwann cell differentiation IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with NAB1: view

Compounds for NAB1 Gene

(1) Novoseek inferred chemical compound relationships for NAB1 Gene

Compound -log(P) Hits PubMed IDs
gnrh 39.2 1
genes like me logo Genes that share compounds with NAB1: view

Transcripts for NAB1 Gene

Unigene Clusters for NAB1 Gene

NGFI-A binding protein 1 (EGR1 binding protein 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - -

Relevant External Links for NAB1 Gene

GeneLoc Exon Structure for
NAB1
ECgene alternative splicing isoforms for
NAB1

Expression for NAB1 Gene

mRNA expression in normal human tissues for NAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAB1 Gene

SOURCE GeneReport for Unigene cluster for NAB1 Gene Hs.107474

mRNA Expression by UniProt/SwissProt for NAB1 Gene

Q13506-NAB1_HUMAN
Tissue specificity: Isoform Short is found in myeloid leukemia cell line KG-1
genes like me logo Genes that share expressions with NAB1: view

No data available for mRNA differential expression in normal tissues for NAB1 Gene

Orthologs for NAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAB1 35
  • 99.59 (n)
  • 100 (a)
NAB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAB1 35
  • 92.2 (n)
  • 95.89 (a)
NAB1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAB1 35
  • 81.14 (n)
  • 86.13 (a)
NAB1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nab1 35
  • 87.7 (n)
  • 92.99 (a)
Nab1 16
Nab1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAB1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nab1 35
  • 87.6 (n)
  • 92.98 (a)
chicken
(Gallus gallus)
Aves NAB1 35
  • 78.33 (n)
  • 87.5 (a)
NAB1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAB1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15920 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nab1 35
  • 71.56 (n)
  • 74.49 (a)
Str.19373 35
zebrafish
(Danio rerio)
Actinopterygii nab1a 36
  • 51 (a)
OneToMany
nab1b 35
  • 65.9 (n)
  • 66.67 (a)
nab1b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nab 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-10 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11359 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6864 36
  • 34 (a)
OneToMany
Species with no ortholog for NAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB1 Gene

ENSEMBL:
Gene Tree for NAB1 (if available)
TreeFam:
Gene Tree for NAB1 (if available)

Paralogs for NAB1 Gene

Paralogs for NAB1 Gene

Selected SIMAP similar genes for NAB1 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for NAB1 Gene

genes like me logo Genes that share paralogs with NAB1: view

Variants for NAB1 Gene

Sequence variations from dbSNP and Humsavar for NAB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs716253 -- 190,663,004(+) CAGCA(A/G)TTTCA intron-variant
rs716254 -- 190,663,375(+) TTTTA(A/G)AGATC intron-variant
rs887693 -- 190,678,238(-) CTTTG(A/G)CTCTT intron-variant
rs929566 -- 190,656,715(-) GATAA(C/G)GCAAT intron-variant
rs929567 -- 190,656,556(-) CAAGT(C/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAB1 Gene

Variant ID Type Subtype PubMed ID
nsv834492 CNV Gain 17160897
nsv3082 CNV Insertion 18451855

Relevant External Links for NAB1 Gene

HapMap Linkage Disequilibrium report
NAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAB1 Gene

Disorders for NAB1 Gene

Relevant External Links for NAB1

Genetic Association Database (GAD)
NAB1
Human Genome Epidemiology (HuGE) Navigator
NAB1
genes like me logo Genes that share disorders with NAB1: view

No data available for UniProtKB/Swiss-Prot for NAB1 Gene

Publications for NAB1 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J. … Milbrandt J. (Mol. Cell. Biol. 1996) 2 3 4 23
  2. The human transcriptional repressor protein NAB1: expression and biological activity. (PMID: 11018254) Thiel G. … Cramer M. (Biochim. Biophys. Acta 2000) 3 23
  3. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PMID: 16574654) Srinivasan R. … Svaren J. (J. Biol. Chem. 2006) 3 23
  4. Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. (PMID: 11687510) Qiu F.H. … Serhan C.N. (FASEB J. 2001) 3 23
  5. Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PMID: 12030330) Venken K. … Svaren J. (Neurogenetics 2002) 3 23

Products for NAB1 Gene

Sources for NAB1 Gene

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