NAB1 Gene

Aliases
for NAB1 gene

Previous GC identifers: GC02P189718 GC02P190226 GC02P191716 GC02P191339 GC02P191222 GC02P183373

Summaries
for NAB1 gene

Genomic Views
for NAB1 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005403.17  

SwitchGear Promoter luciferase reporter plasmid: NAB1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAB1

NAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P191477:  view genomic region     (about GC identifiers)

Proteins
for NAB1 gene

1 PDB 3D structure from and Proteopedia for NAB1:

2YUF (3D)    

Explore the universe of human proteins at neXtProt for NAB1: NX_Q13506

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NAB1 OriGene Protein Over-expression Lysate: NAB1 OriGene Custom Protein Services for NAB1
	GenScript Custom Purified and Recombinant Proteins Services for NAB1
	Novus Biologicals NAB1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NAB1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NAB1
	GenScript Superior Antibodies for NAB1
	Novus Biologicals NAB1 Antibodies
	Abcam antibodies for NAB1
	Uscn Antibodies for NAB1
	Search ThermoFisher Antibodies for NAB1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NAB1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NAB1

Protein Domains /
Families
for NAB1 gene

ProtoNet protein and cluster: Q13506

Function
for NAB1 gene

miRNA Products:		OriGene 3'-UTR Clone: NAB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAB1
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate NAB1 (see all 74):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-1224-3p hsa-miR-411 hsa-miR-128 hsa-miR-1245 hsa-miR-200a hsa-miR-578
		SwitchGear 3'UTR luciferase reporter plasmid: NAB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAB1 (see all 7) OriGene shRNA RFP: NAB1 OriGene siRNA: NAB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAB1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NAB1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAB1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAB1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NAB1 (NM_005966)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NAB1
		Search LifeMap BioReagents cell lines for NAB1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Nab1)

Pathways & Interactions
for NAB1 gene

	Super-pathway	contained gene-specific pathways
1	Integrated Breast Cancer Pathway	Integrated Breast Cancer Pathway 1.00

1 BioSystems Pathway for NAB1

Integrated Breast Cancer Pathway

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for NAB1 gene

Transcripts
for NAB1 gene

Expression
for NAB1 gene

NAB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACGTTTCC

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Head MesenchymeBranchial Arch 1Paraxial Mesoderm Cells			Bone, Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAB1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAB1

Orthologs
for NAB1 gene

Paralogs
for NAB1 gene

Paralogs for NAB1 gene

NAB2²  

1 SIMAP similar gene for NAB1 using alignment to 10 protein entries:     NAB1_HUMAN (see all proteins):

NAB2

NAB1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for NAB1
PGOHUM00000241598

Genomic Variants
for NAB1 gene

10/646 NCBI SNPs in NAB1 are shown (see all 646)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1444180361,2	C	other	191523989(+)	GATGCC/TTTTAT	2	A	syn1		1		NA	4550
rs1877392831,2		--	191511886(+)	TGCAGC/TTAAAG	1	--	us2k1		0	--	--	--	--
rs126935821,2	C,F,A,	--	191511939(+)	TCAACT/CACTCC	1	--	us2k1		8		NA CSA WA EA	368
rs75945181,2	C,F,A,	--	191511994(+)	ATTATA/GTGTAT	1	--	us2k1		9		NA WA EA	370
rs133826041,2	C,F,	--	191512030(+)	TAACAT/CGATTT	1	--	us2k1		6		NA CSA WA EA	364
rs793086391,2	F,	--	191512349(+)	TTCCAC/TTTTTT	1	--	us2k1		2		NA EA	240
rs791672311,2	C,F,	--	191512371(+)	AAATAA/C/G/T          AGATT	1	--	us2k1		1		NA	120
rs2010816091,2		--	191512438(+)	TTCTT-/CTTTTT	1	--	us2k1		0	--	--	--	--
rs109314671,2	C,F,H,	--	191512439(+)	TTCTTT/CTTTTT	1	--	us2k1 trp3		13		NS EA NA	1970
rs1922243711,2		--	191512492(+)	CTGGAA/GTGCAA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for NAB1 (191511472 - 191557492 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NAB1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAB1

DNA2.0 Custom Variant and Variant Library Synthesis for NAB1

Disorders / Diseases
for NAB1 gene

Publications
for NAB1 gene

PubMed articles for NAB1 gene, integrated from 9 sources (see all 29): (articles sorted by number of sources associating them with NAB1)

Utopia: connect your pdf to the dynamic world of online information

1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PubMed id 8668170)^{1, 2, 3, 9} Svaren J....Milbrandt J. (1996)
2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. (PubMed id 9418898)^{1, 3} Swirnoff A.H....Milbrandt J. (1998)
6. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. (PubMed id 7624335)^{1, 3} Russo M.W....Milbrandt J. (1995)
7. The human transcriptional repressor protein NAB1: expression and biological activity. (PubMed id 11018254)^{1, 9} Thiel G....Cramer M. (2000)
8. Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PubMed id 12030330)^{1, 9} Venken K....Svaren J. (2002)
9. Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. (PubMed id 11687510)^{1, 9} Qiu F.H....Serhan C.N. (2001)
10. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PubMed id 16574654)^{1, 9} Srinivasan R....Svaren J. (2006)

External Searches for NAB1 gene

Genome Databases showing NAB1 gene

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Specialized Databases showing NAB1 gene

Products
for NAB1 gene