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Aliases for NAB1 Gene

Aliases for NAB1 Gene

  • NGFI-A Binding Protein 1 2 3 5
  • NGFI-A Binding Protein 1 (EGR1 Binding Protein 1) 2
  • Transcriptional Regulatory Protein P54 4
  • EGR-1-Binding Protein 1 4
  • EGR1 Binding Protein 1 2

External Ids for NAB1 Gene

Previous GeneCards Identifiers for NAB1 Gene

  • GC02P189718
  • GC02P190226
  • GC02P191477
  • GC02P191716
  • GC02P191339
  • GC02P191222
  • GC02P183373

Summaries for NAB1 Gene

GeneCards Summary for NAB1 Gene

NAB1 (NGFI-A Binding Protein 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is NAB2.

UniProtKB/Swiss-Prot for NAB1 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Gene Wiki entry for NAB1 Gene

Additional gene information for NAB1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAB1 Gene

Genomics for NAB1 Gene

Regulatory Elements for NAB1 Gene

Enhancers for NAB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H190646 1.6 FANTOM5 ENCODE dbSUPER 25.7 +2.2 2228 5 ATF1 FOXA2 ARID4B SIN3A DMAP1 GLIS2 ZNF143 ZNF207 ATF7 SP3 NAB1 NEMP2 ENSG00000233654 ENSG00000228509 GLS HIBCH STAT1 INPP1 ENSG00000284052
GH02H190605 1.4 Ensembl ENCODE dbSUPER 27.1 -39.3 -39331 3 TBP HDGF PKNOX1 SIN3A TCF12 EGR1 ATF7 FOS CREM IKZF2 NEMP2 NAB1 MFSD6 ENSG00000233654 ENSG00000228509 GC02M190569
GH02H190466 1.4 Ensembl ENCODE dbSUPER 24.6 -177.7 -177689 4 HDAC1 NFIB FEZF1 PLRG1 BMI1 RAD21 GATA2 ZNF366 ZSCAN5C RCOR1 NEMP2 NAB1 MFSD6 ENSG00000233654 ENSG00000272979 GC02P190518
GH02H190636 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.8 -9.5 -9506 1 SMARCE1 PKNOX1 JUN CEBPB DPF2 EP300 OSR2 FOSL1 JUND PRDM6 NAB1 STAT1 INPP1 GLS GC02M190569
GH02H190843 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +197.8 197785 2 KLF17 SIN3A BATF FOSL1 ZNF316 POLR2A FOS NFE2 RUNX3 MAFK GLS NAB1 ENSG00000228509 ENSG00000235852 LOC105373805 STAT4 STAT1 GC02M190697
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAB1 Gene

Chromosome:
2
Start:
190,646,746 bp from pter
End:
190,692,766 bp from pter
Size:
46,021 bases
Orientation:
Plus strand

Genomic View for NAB1 Gene

Genes around NAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAB1 Gene

Proteins for NAB1 Gene

  • Protein details for NAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13506-NAB1_HUMAN
    Recommended name:
    NGFI-A-binding protein 1
    Protein Accession:
    Q13506
    Secondary Accessions:
    • O75383
    • O75384
    • Q6GTU1
    • Q9UEV1

    Protein attributes for NAB1 Gene

    Size:
    487 amino acids
    Molecular mass:
    54401 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Three dimensional structures from OCA and Proteopedia for NAB1 Gene

    Alternative splice isoforms for NAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB1 Gene

Post-translational modifications for NAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for NAB1

No data available for DME Specific Peptides for NAB1 Gene

Domains & Families for NAB1 Gene

Gene Families for NAB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAB1 Gene

Suggested Antigen Peptide Sequences for NAB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13506

UniProtKB/Swiss-Prot:

NAB1_HUMAN :
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • Belongs to the NAB family.
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Family:
  • Belongs to the NAB family.
genes like me logo Genes that share domains with NAB1: view

Function for NAB1 Gene

Molecular function for NAB1 Gene

GENATLAS Biochemistry:
NGFI-A (nerve growth factor induced clone A) binding protein 1 (EGR1 binding protein) also repressor of EGR2
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Phenotypes From GWAS Catalog for NAB1 Gene

Gene Ontology (GO) - Molecular Function for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with NAB1: view
genes like me logo Genes that share phenotypes with NAB1: view

Animal Models for NAB1 Gene

MGI Knock Outs for NAB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAB1 Gene

Localization for NAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAB1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
golgi apparatus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IEA 8668170
genes like me logo Genes that share ontologies with NAB1: view

Pathways & Interactions for NAB1 Gene

genes like me logo Genes that share pathways with NAB1: view

Pathways by source for NAB1 Gene

1 BioSystems pathway for NAB1 Gene

Gene Ontology (GO) - Biological Process for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8668170
GO:0014037 Schwann cell differentiation IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with NAB1: view

No data available for SIGNOR curated interactions for NAB1 Gene

Drugs & Compounds for NAB1 Gene

(1) Additional Compounds for NAB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAB1: view

Transcripts for NAB1 Gene

Unigene Clusters for NAB1 Gene

NGFI-A binding protein 1 (EGR1 binding protein 1):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NAB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - -

Relevant External Links for NAB1 Gene

GeneLoc Exon Structure for
NAB1
ECgene alternative splicing isoforms for
NAB1

Expression for NAB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAB1 Gene

This gene is overexpressed in Serum (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAB1 Gene



Protein tissue co-expression partners for NAB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAB1 Gene:

NAB1

SOURCE GeneReport for Unigene cluster for NAB1 Gene:

Hs.107474

mRNA Expression by UniProt/SwissProt for NAB1 Gene:

Q13506-NAB1_HUMAN
Tissue specificity: Isoform Short is found in myeloid leukemia cell line KG-1.

Evidence on tissue expression from TISSUES for NAB1 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Pancreas(2.6)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with NAB1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAB1 Gene

Orthologs for NAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAB1 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia NAB1 33 34
  • 92.2 (n)
oppossum
(Monodelphis domestica)
Mammalia NAB1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nab1 33 16 34
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia Nab1 33
  • 87.6 (n)
dog
(Canis familiaris)
Mammalia NAB1 33 34
  • 81.14 (n)
chicken
(Gallus gallus)
Aves NAB1 33 34
  • 78.33 (n)
lizard
(Anolis carolinensis)
Reptilia NAB1 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nab1 33
  • 71.56 (n)
Str.19373 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15920 33
zebrafish
(Danio rerio)
Actinopterygii nab1b 33 34
  • 65.9 (n)
nab1a 34
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nab 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-10 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6864 34
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11359 33
Species where no ortholog for NAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB1 Gene

ENSEMBL:
Gene Tree for NAB1 (if available)
TreeFam:
Gene Tree for NAB1 (if available)

Paralogs for NAB1 Gene

Paralogs for NAB1 Gene

(1) SIMAP similar genes for NAB1 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for NAB1 Gene

genes like me logo Genes that share paralogs with NAB1: view

Variants for NAB1 Gene

Sequence variations from dbSNP and Humsavar for NAB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000001698 -- 190,676,069(+) CTTTA(A/T)GTCTA intron-variant
rs1000037170 -- 190,676,458(+) GCATG(A/G)TGGCT intron-variant
rs1000067459 -- 190,647,509(+) AAAAC(-/TT)GATTT upstream-variant-2KB
rs1000088218 -- 190,662,474(+) TGAAG(A/T)GAGTG intron-variant
rs1000093194 -- 190,647,805(+) CGCCT(C/T)CCGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAB1 Gene

Variant ID Type Subtype PubMed ID
dgv1200e212 CNV loss 25503493
esv3584252 CNV loss 25503493
nsv1072472 CNV deletion 25765185
nsv3082 CNV insertion 18451855
nsv834492 CNV gain 17160897

Variation tolerance for NAB1 Gene

Residual Variation Intolerance Score: 8.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAB1 Gene

Disorders for NAB1 Gene

Relevant External Links for NAB1

Genetic Association Database (GAD)
NAB1
Human Genome Epidemiology (HuGE) Navigator
NAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAB1

No disorders were found for NAB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAB1 Gene

Publications for NAB1 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J … Milbrandt J (Molecular and cellular biology 1996) 2 3 4 22 60
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PMID: 16574654) Srinivasan R … Svaren J (The Journal of biological chemistry 2006) 3 22 60

Products for NAB1 Gene

Sources for NAB1 Gene

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