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Aliases & Descriptions for NAB1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| EGR-1-binding protein 1 3 | | EGR1 binding protein 1 2 | | NGFI-A binding protein 1 2 | | NGFI-A binding protein 1 (EGR1 binding protein 1) 2 | | Transcriptional regulatory protein p54 3 |
|
| | Search outside databases for aliases for NAB1 genePrevious GC identifers: GC02P189718 GC02P190226 GC02P191477 GC02P191716 GC02P191339 |
Summaries for NAB1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NAB1_HUMAN, Q13506Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity)Gene Wiki entry for NAB1 |
Genomic Location for NAB1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAB1 gene 
Entrez Gene cytogenetic band: 2q32.3-q33 Ensembl cytogenetic band: 2q32.2 HGNC cytogenetic band: 2q32.3-q33NAB1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P191222:
(about GC identifiers)
Start:
|
191,222,041 bp from pter |
End:
|
191,265,737 bp from pter |
Size:
|
43,697 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for NAB1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NAB1_HUMAN, Q13506 (See
protein sequence)Recommended Name: NGFI-A-binding protein 1 Size: 487 amino acids; 54401 Da
Subunit: Homomultimers may associate with EGR1 bound to DNA (By similarity)
Subcellular location: Nucleus (By similarity)
PDB structures from and Proteopedia :2YUF (3D)
 
Secondary accessions: O75383 O75384 Q6GTU1 Q9UEV1Alternative splicing: 2 isoforms: Q13506-1 Q13506-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005957.2
ENSEMBL proteins: ENSP00000336894 ENSP00000349749 ENSP00000387089 ENSP00000386682
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NAB1 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for NAB1: Assays for NAB1: | Protein
Domains/ Families for NAB1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13506
ProtoNet protein and cluster: Q13506 1 Blocks protein family: IPB006986 Nab1
UniProtKB/Swiss-Prot: NAB1_HUMAN, Q13506Domain: The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerizationDomain: The NAB conserved domain 2 (NCD2) is necessary for transcriptional repressionSimilarity: Belongs to the NAB family | Gene Function for NAB1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005966
Applied Biosystems Silencer® siRNAs for NAB1
Sigma-Aldrich siRNA for NAB1  Sigma-Aldrich shRNA for NAB1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005966                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005966                                  untagged cDNA clone in CMV expression vector: NM_005966 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005966
UniProtKB/Swiss-Prot: NAB1_HUMAN, Q13506Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity)Genatlas biochemistry entry for NAB1:NGFI-A (nerve growth factor induced clone A) binding protein 1 (EGR1 binding protein) also repressor of EGR210 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nab1):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016564 | transcription repressor activity |
NAS | 8668170 | About this table | Pathways & Interactions for NAB1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for NAB1 
3 Interacting proteins for NAB1 (ENSP000003368943) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 8668170 | | GO:0016481 | negative regulation of transcription |
IEA | -- | About this table
|
Drugs & Compounds for NAB1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAB1
|
Transcripts for NAB1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005966
Sigma-Aldrich siRNA for NAB1  Sigma-Aldrich shRNA for NAB1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005966 REFSEQ mRNAs for NAB1 gene: NM_005966.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005966               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005966                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005966                                  untagged cDNA clone in CMV expression vector: NM_005966  Additional cDNA sequence: AF045451.1 AF045452.1 AK292446.1 AK296549.1 AK313542.1 BC035724.1 U47007.1 12 DOTS entries: DT.415016 DT.95374036 DT.100777911 DT.70105379 DT.100674142 DT.75104531 DT.95192760 DT.95374031 DT.120967271 DT.120967303 DT.120967255 DT.95075512 24/181 AceView cDNA sequences (see all 181
):AA464835 AW949339 BM757930 AA243485 AA968597 AL703348 F11652 NM_005966 BE041507 BM847145 AW340316 CB528843 BM837857 AA287080 BG681694 BM467050 AU125407 AI884323 T30554 AF045451 CA314681 AA687766 AA994001 BI793037
highest scoring ESTs for NAB1:AF045451 AA243423 AA243485 AA287080 AA287081 AA325121 AA401060 AA401067 AA426439 AA437171 Unigene Cluster for NAB1: NGFI-A binding protein 1 (EGR1 binding protein 1) Hs.570078 [show with all ESTs]Unigene Representative Sequence: NM_005966
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAB1 (see all 10
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | |
| SP1: | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAB1
4 Ensembl transcripts including schematic representations: ENST00000337386
ENST00000357215
ENST00000409581
ENST00000409641
|
Expression for NAB1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAB1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAB1
1 / 2 / 3 7 probe-sets matching NAB1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAACGTTTCC
SOURCE GeneReport for Unigene cluster: Hs.570078
Expression variation in blood from EXPOLDB for NAB1 UniProtKB/Swiss-Prot: NAB1_HUMAN, Q13506Tissue specificity: The short isoform is found in a myeloid Leukemia cell line |
Orthologs for NAB1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAB1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for NAB1
ENSEMBL Gene Tree for NAB1 | Paralogs for NAB1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAB1 gene
- NAB22
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for NAB1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAB1 (up to first 250kb)
|
Disorders & Mutations for NAB1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600800
1 PharmGKB disease relationship for NAB1 geneAbout this table
|
Medical News for NAB1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAB1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for NAB1 gene (see all 20
):- NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PubMed id 8668170)1, 2, 3, 4 Svaren J....Milbrandt J. (1996)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. (PubMed id 9418898)2, 3 Swirnoff A.H....Milbrandt J. (1998)
- Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. (PubMed id 7624335)2, 3 Russo M.W....Milbrandt J. (1995)
- The human transcriptional repressor protein NAB1: expression and biological activity. (PubMed id 11018254)1, 3 Thiel G....Cramer M. (2000)
- Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (PubMed id 12030330)1, 3 Venken K....Svaren J. (2002)
- Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. (PubMed id 11687510)1, 3 Qiu F.H....Serhan C.N. (2001)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
|
Search for NAB1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAB1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAB1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAB1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAB1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAB1:

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| | Recombinant Proteins (NAB1) | | Antibodies (NAB1) |
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Incremental update: 13 Oct 2009
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