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Aliases for NAB1 Gene

Aliases for NAB1 Gene

  • NGFI-A Binding Protein 1 2 3 5
  • NGFI-A Binding Protein 1 (EGR1 Binding Protein 1) 2
  • Transcriptional Regulatory Protein P54 4
  • EGR-1-Binding Protein 1 4
  • EGR1 Binding Protein 1 2

External Ids for NAB1 Gene

Previous GeneCards Identifiers for NAB1 Gene

  • GC02P189718
  • GC02P190226
  • GC02P191477
  • GC02P191716
  • GC02P191339
  • GC02P191222
  • GC02P183373

Summaries for NAB1 Gene

GeneCards Summary for NAB1 Gene

NAB1 (NGFI-A Binding Protein 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is NAB2.

UniProtKB/Swiss-Prot for NAB1 Gene

  • Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Gene Wiki entry for NAB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAB1 Gene

Genomics for NAB1 Gene

Regulatory Elements for NAB1 Gene

Enhancers for NAB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F190605 0.8 Ensembl ENCODE 27.1 -39.3 -39331 3.4 HDGF TBP PKNOX1 SIN3A FOS CREM EGR2 SMARCC1 CEBPB TBX21 NEMP2 NAB1 MFSD6 ENSG00000233654 ENSG00000228509 GC02M190569
GH02F190636 1.2 FANTOM5 Ensembl ENCODE 26.1 -9.4 -9446 2.2 CTCF PKNOX1 JUN ZNF384 ZBTB40 RAD21 SCRT2 SMC3 PRDM10 FOS NAB1 GLS STAT1 INPP1 GC02M190569
GH02F190646 1.3 FANTOM5 ENCODE 25.7 +2.2 2228 5.6 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF207 ZNF263 SP3 NAB1 NEMP2 ENSG00000233654 ENSG00000228509 GLS HIBCH STAT1 INPP1 GC02M190675
GH02F190545 0.2 Ensembl 20.6 -101.1 -101091 1.3 BHLHE40 MFSD6 NAB1 NEMP2 GC02M190554
GH02F190537 0.7 ENCODE 19.2 -108.8 -108757 0.2 RFX1 BMI1 REST UBTF SP1 ZNF585B SETDB1 SPI1 NAB1 OSGEPL1-AS1 OSGEPL1 ENSG00000233654 NEMP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAB1 Gene

Chromosome:
2
Start:
190,646,746 bp from pter
End:
190,692,766 bp from pter
Size:
46,021 bases
Orientation:
Plus strand

Genomic View for NAB1 Gene

Genes around NAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAB1 Gene

Proteins for NAB1 Gene

  • Protein details for NAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13506-NAB1_HUMAN
    Recommended name:
    NGFI-A-binding protein 1
    Protein Accession:
    Q13506
    Secondary Accessions:
    • O75383
    • O75384
    • Q6GTU1
    • Q9UEV1

    Protein attributes for NAB1 Gene

    Size:
    487 amino acids
    Molecular mass:
    54401 Da
    Quaternary structure:
    • Homomultimers may associate with EGR1 bound to DNA.

    Three dimensional structures from OCA and Proteopedia for NAB1 Gene

    Alternative splice isoforms for NAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAB1 Gene

Post-translational modifications for NAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for NAB1

No data available for DME Specific Peptides for NAB1 Gene

Domains & Families for NAB1 Gene

Protein Domains for NAB1 Gene

Suggested Antigen Peptide Sequences for NAB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13506

UniProtKB/Swiss-Prot:

NAB1_HUMAN :
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • Belongs to the NAB family.
Domain:
  • The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
  • The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Family:
  • Belongs to the NAB family.
genes like me logo Genes that share domains with NAB1: view

No data available for Gene Families for NAB1 Gene

Function for NAB1 Gene

Molecular function for NAB1 Gene

GENATLAS Biochemistry:
NGFI-A (nerve growth factor induced clone A) binding protein 1 (EGR1 binding protein) also repressor of EGR2
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.

Gene Ontology (GO) - Molecular Function for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000989 transcription factor activity, transcription factor binding IBA --
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with NAB1: view
genes like me logo Genes that share phenotypes with NAB1: view

Animal Models for NAB1 Gene

MGI Knock Outs for NAB1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAB1 Gene

Localization for NAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAB1 Gene COMPARTMENTS Subcellular localization image for NAB1 gene
Compartment Confidence
nucleus 5
golgi apparatus 2
plasma membrane 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 8668170
genes like me logo Genes that share ontologies with NAB1: view

Pathways & Interactions for NAB1 Gene

SuperPathways for NAB1 Gene

genes like me logo Genes that share pathways with NAB1: view

Pathways by source for NAB1 Gene

1 BioSystems pathway for NAB1 Gene

Gene Ontology (GO) - Biological Process for NAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8668170
GO:0007399 nervous system development IBA --
GO:0014037 Schwann cell differentiation IEA --
genes like me logo Genes that share ontologies with NAB1: view

No data available for SIGNOR curated interactions for NAB1 Gene

Drugs & Compounds for NAB1 Gene

(1) Additional Compounds for NAB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAB1: view

Transcripts for NAB1 Gene

Unigene Clusters for NAB1 Gene

NGFI-A binding protein 1 (EGR1 binding protein 1):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2:
SP3: -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - -

Relevant External Links for NAB1 Gene

GeneLoc Exon Structure for
NAB1
ECgene alternative splicing isoforms for
NAB1

Expression for NAB1 Gene

mRNA expression in normal human tissues for NAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAB1 Gene

This gene is overexpressed in Serum (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAB1 Gene



Protein tissue co-expression partners for NAB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAB1 Gene:

NAB1

SOURCE GeneReport for Unigene cluster for NAB1 Gene:

Hs.107474

mRNA Expression by UniProt/SwissProt for NAB1 Gene:

Q13506-NAB1_HUMAN
Tissue specificity: Isoform Short is found in myeloid leukemia cell line KG-1.
genes like me logo Genes that share expression patterns with NAB1: view

Primer Products

No data available for mRNA differential expression in normal tissues for NAB1 Gene

Orthologs for NAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAB1 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia NAB1 34 35
  • 92.2 (n)
oppossum
(Monodelphis domestica)
Mammalia NAB1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nab1 34 16 35
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia Nab1 34
  • 87.6 (n)
dog
(Canis familiaris)
Mammalia NAB1 34 35
  • 81.14 (n)
chicken
(Gallus gallus)
Aves NAB1 34 35
  • 78.33 (n)
lizard
(Anolis carolinensis)
Reptilia NAB1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nab1 34
  • 71.56 (n)
Str.19373 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15920 34
zebrafish
(Danio rerio)
Actinopterygii nab1b 34 35
  • 65.9 (n)
nab1a 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nab 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mab-10 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6864 35
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11359 34
Species where no ortholog for NAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAB1 Gene

ENSEMBL:
Gene Tree for NAB1 (if available)
TreeFam:
Gene Tree for NAB1 (if available)

Paralogs for NAB1 Gene

Paralogs for NAB1 Gene

(1) SIMAP similar genes for NAB1 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for NAB1 Gene

genes like me logo Genes that share paralogs with NAB1: view

Variants for NAB1 Gene

Sequence variations from dbSNP and Humsavar for NAB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10171127 -- 190,665,318(+) actcc(A/G)tctca intron-variant
rs10185029 -- 190,683,501(+) TCCAG(C/T)GTAAA intron-variant
rs10194491 -- 190,670,778(+) TAGAC(G/T)TATTT intron-variant
rs10194854 -- 190,665,184(+) ggggc(A/G)tggtg intron-variant
rs10195660 -- 190,683,081(+) GTTAA(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAB1 Gene

Variant ID Type Subtype PubMed ID
dgv1200e212 CNV loss 25503493
esv3584252 CNV loss 25503493
nsv1072472 CNV deletion 25765185
nsv3082 CNV insertion 18451855
nsv834492 CNV gain 17160897

Variation tolerance for NAB1 Gene

Residual Variation Intolerance Score: 8.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAB1 Gene

Disorders for NAB1 Gene

Relevant External Links for NAB1

Genetic Association Database (GAD)
NAB1
Human Genome Epidemiology (HuGE) Navigator
NAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAB1

No disorders were found for NAB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAB1 Gene

Publications for NAB1 Gene

  1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. (PMID: 8668170) Svaren J. … Milbrandt J. (Mol. Cell. Biol. 1996) 2 3 4 22 64
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. (PMID: 16574654) Srinivasan R. … Svaren J. (J. Biol. Chem. 2006) 3 22 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for NAB1 Gene

Sources for NAB1 Gene

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