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Aliases for NAALADL2 Gene

Aliases for NAALADL2 Gene

  • N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 2 2 3
  • Glutamate Carboxypeptidase II-Type Non-Peptidase Homologue 2
  • NAALADase L2 4

External Ids for NAALADL2 Gene

Previous GeneCards Identifiers for NAALADL2 Gene

  • GC03P175899
  • GC03P176059
  • GC03P174156
  • GC03P171954

Summaries for NAALADL2 Gene

GeneCards Summary for NAALADL2 Gene

NAALADL2 (N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 2) is a Protein Coding gene. GO annotations related to this gene include peptidase activity. An important paralog of this gene is FOLH1.

UniProtKB/Swiss-Prot for NAALADL2 Gene

  • May be catalytically inactive

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAALADL2 Gene

Genomics for NAALADL2 Gene

Regulatory Elements for NAALADL2 Gene

Genomic Location for NAALADL2 Gene

174,438,573 bp from pter
175,805,640 bp from pter
1,367,068 bases
Plus strand

Genomic View for NAALADL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAALADL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAALADL2 Gene

Proteins for NAALADL2 Gene

  • Protein details for NAALADL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q658X9
    • Q6H9J8
    • Q6H9J9
    • Q6PG38

    Protein attributes for NAALADL2 Gene

    795 amino acids
    Molecular mass:
    88682 Da
    Quaternary structure:
    No Data Available
    • The gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome. However, PubMed:15168106 failed to identify specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome
    • Sequence=CAE54974.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence at the C-terminus.; Evidence={ECO:0000305}; Sequence=CAH56310.1; Type=Frameshift; Positions=509, 518; Evidence={ECO:0000305};

    Alternative splice isoforms for NAALADL2 Gene


neXtProt entry for NAALADL2 Gene

Proteomics data for NAALADL2 Gene at MOPED

Post-translational modifications for NAALADL2 Gene

  • Glycosylation at Asn295, Asn373, Asn534, and Asn759
  • Modification sites at PhosphoSitePlus

Other Protein References for NAALADL2 Gene

Antibody Products

  • R&D Systems Antibodies for NAALADL2 (NAALADase-like 2/NAALADL2)

No data available for DME Specific Peptides for NAALADL2 Gene

Domains for NAALADL2 Gene

Protein Domains for NAALADL2 Gene

Suggested Antigen Peptide Sequences for NAALADL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q58DX5
  • Belongs to the peptidase M28 family. M28B subfamily.
genes like me logo Genes that share domains with NAALADL2: view

No data available for Gene Families for NAALADL2 Gene

Function for NAALADL2 Gene

Molecular function for NAALADL2 Gene

UniProtKB/Swiss-Prot Function:
May be catalytically inactive

Gene Ontology (GO) - Molecular Function for NAALADL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NAALADL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAALADL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAALADL2 Gene

Localization for NAALADL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAALADL2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for NAALADL2 Gene COMPARTMENTS Subcellular localization image for NAALADL2 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NAALADL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NAALADL2: view

Pathways for NAALADL2 Gene

SuperPathways for NAALADL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAALADL2 Gene


No data available for Pathways by source for NAALADL2 Gene

Transcripts for NAALADL2 Gene


(1) Selected AceView cDNA sequences:
(8) REFSEQ mRNAs :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAALADL2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAALADL2 Gene

No ASD Table

Relevant External Links for NAALADL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAALADL2 Gene

mRNA expression in normal human tissues for NAALADL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAALADL2 Gene

This gene is overexpressed in Minor Salivary Gland (5.7).

Protein differential expression in normal tissues for NAALADL2 Gene

This gene is overexpressed in Placenta (25.7), Pancreas (17.1), Salivary gland (8.5), and Prostate (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAALADL2 Gene

SOURCE GeneReport for Unigene cluster for NAALADL2 Gene Hs.565848

mRNA Expression by UniProt/SwissProt for NAALADL2 Gene

Tissue specificity: Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas
genes like me logo Genes that share expressions with NAALADL2: view

In Situ Assay Products

No data available for Expression partners for NAALADL2 Gene

Orthologs for NAALADL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAALADL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAALADL2 35
  • 86.83 (n)
  • 83.86 (a)
(Canis familiaris)
Mammalia NAALADL2 35
  • 87.28 (n)
  • 83.38 (a)
  • 83 (a)
(Mus musculus)
Mammalia Naaladl2 35
  • 81.8 (n)
  • 77.99 (a)
Naaladl2 16
(Pan troglodytes)
Mammalia NAALADL2 35
  • 99.04 (n)
  • 98.49 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Naaladl2 35
  • 81.97 (n)
  • 78.42 (a)
(Monodelphis domestica)
Mammalia NAALADL2 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NAALADL2 36
  • 68 (a)
(Gallus gallus)
Aves NAALADL2 35
  • 71.89 (n)
  • 66.25 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia NAALADL2 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498087 35
  • 60.27 (n)
  • 50.13 (a)
(Danio rerio)
Actinopterygii LOC101885785 35
  • 53.55 (n)
  • 45.74 (a)
CU179643.1 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS70 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for NAALADL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAALADL2 Gene

Gene Tree for NAALADL2 (if available)
Gene Tree for NAALADL2 (if available)

Paralogs for NAALADL2 Gene

Paralogs for NAALADL2 Gene

genes like me logo Genes that share paralogs with NAALADL2: view

Variants for NAALADL2 Gene

Sequence variations from dbSNP and Humsavar for NAALADL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14890 -- 175,718,545(-) ATGAA(C/G)ATATG intron-variant
rs471474 -- 174,611,559(+) tgccc(A/G)tgagt intron-variant
rs472662 -- 174,661,045(+) GGTAT(A/G)TAGAG intron-variant
rs473285 -- 174,748,020(-) ctcca(C/T)ccacg intron-variant
rs473655 -- 174,596,917(-) TCAGG(C/G)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAALADL2 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv878008 CNV Loss 21882294
nsv822346 CNV Loss 20364138
nsv878009 CNV Loss 21882294
nsv878010 CNV Loss 21882294
esv2077484 CNV Deletion 18987734
esv2664654 CNV Deletion 23128226
esv2656734 CNV Deletion 23128226
nsv829798 CNV Gain 17160897
esv2502889 CNV Deletion 19546169
nsv829799 CNV Gain 17160897
nsv236658 CNV Loss 16902084
nsv878011 CNV Gain 21882294
nsv878012 CNV Gain 21882294
esv267527 CNV Insertion 20981092
esv268896 CNV Insertion 20981092
esv2676736 CNV Deletion 23128226
nsv471082 CNV Loss 18288195
esv25430 CNV Loss 19812545
nsv461021 CNV Loss 19166990
nsv436927 CNV Loss 16327808
nsv878013 CNV Gain 21882294
esv2672851 CNV Deletion 23128226
nsv829800 CNV Gain+Loss 17160897
nsv525074 CNV Loss 19592680
esv1002088 CNV Insertion 20482838
nsv237834 CNV Insertion 16902084
nsv510887 CNV Complex 20534489
esv275442 CNV Gain+Loss 21479260
nsv437349 CNV Loss 16327808
nsv878014 CNV Loss 21882294
nsv471093 CNV Loss 18288195
nsv878015 CNV Gain 21882294
nsv10360 CNV Loss 18304495
dgv897e199 CNV Deletion 23128226
esv25293 CNV Loss 19812545
esv2657792 CNV Deletion 23128226
dgv841n67 CNV Loss 20364138
nsv437898 CNV Loss 16468122
nsv526163 CNV Loss 19592680
nsv4126 CNV Insertion 18451855
esv32881 CNV Loss 17666407
nsv461022 CNV Loss 19166990
nsv878016 CNV Loss 21882294
nsv878017 CNV Loss 21882294
nsv818193 CNV Gain 17921354
nsv829801 CNV Gain 17160897
nsv461023 CNV Loss 19166990
esv21640 CNV Loss 19812545
nsv878018 CNV Loss 21882294
esv2634942 CNV Deletion 19546169
nsv878019 CNV Loss 21882294
esv34059 CNV Loss 18971310
nsv509867 CNV Loss 20534489
nsv878020 CNV Loss 21882294
nsv507141 CNV Insertion 20534489
esv2231955 CNV Deletion 18987734
esv2726228 CNV Deletion 23290073
esv2726230 CNV Deletion 23290073
nsv523336 CNV Loss 19592680
esv2726231 CNV Deletion 23290073
nsv878021 CNV Loss 21882294
nsv878022 CNV Loss 21882294
esv2651072 CNV Deletion 19546169
nsv878023 CNV Loss 21882294

Relevant External Links for NAALADL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAALADL2 Gene

Disorders for NAALADL2 Gene

(1) University of Copenhagen DISEASES for NAALADL2 Gene

Relevant External Links for NAALADL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NAALADL2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NAALADL2 Gene

Publications for NAALADL2 Gene

  1. A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3. (PMID: 15168106) Tonkin E.T. … Strachan T. (Hum. Genet. 2004) 2 3 4 23
  2. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D. … Hibberd M.L. (PLoS Genet. 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung S.A. … Criswell L.A. (PLoS Genet. 2011) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for NAALADL2 Gene

Sources for NAALADL2 Gene

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