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Aliases for NAALADL1 Gene

Aliases for NAALADL1 Gene

  • N-Acetylated Alpha-Linked Acidic Dipeptidase Like 1 2 3 5
  • 100 KDa Ileum Brush Border Membrane Protein 3 4
  • Ileal Dipeptidylpeptidase 3 4
  • Ileal Peptidase I100 2 3
  • NAALADase L 3 4
  • NAALADASEL 3 4
  • I100 3 4
  • N-Acetylated-Alpha-Linked Acidic Dipeptidase-Like Protein 3
  • Peptidase Homolog 3
  • EC 3.4.17.21 4
  • NAALADL 4

External Ids for NAALADL1 Gene

Previous GeneCards Identifiers for NAALADL1 Gene

  • GC11M064588
  • GC11M064569
  • GC11M064812
  • GC11M061139

Summaries for NAALADL1 Gene

GeneCards Summary for NAALADL1 Gene

NAALADL1 (N-Acetylated Alpha-Linked Acidic Dipeptidase Like 1) is a Protein Coding gene. GO annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is FOLH1.

UniProtKB/Swiss-Prot for NAALADL1 Gene

  • NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).

Additional gene information for NAALADL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAALADL1 Gene

Genomics for NAALADL1 Gene

Regulatory Elements for NAALADL1 Gene

Enhancers for NAALADL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 36.4 -431.1 -431063 40 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 24.3 -365.2 -365161 18.8 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H065886 1.9 FANTOM5 ENCODE dbSUPER 13.4 -836.4 -836438 18.4 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SNX32 RBM14 ENSG00000258297 ENSG00000254461 MUS81 SART1 CTSW KAT5 SF3B2 EIF1AD
GH11H064331 1.6 Ensembl ENCODE dbSUPER 15.1 +727.1 727129 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF207 ZNF143 FOS MCM3 SF1 POLA2 PLCB3 ZFPL1 ENSG00000257086 FAU ATG2A ZNHIT2 NAALADL1 IMMP1LP1
GH11H064267 1.4 ENCODE dbSUPER 15.1 +788.3 788322 7.2 DMAP1 YY1 SLC30A9 ZNF143 SP3 MCM3 NFYC MEF2D SSRP1 ZNF585B ZFPL1 SF1 POLA2 PLCB3 ENSG00000257086 TRMT112 DNAJC4 FAU LOC102723878 TRPT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAALADL1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NAALADL1 gene promoter:

Genomic Locations for NAALADL1 Gene

Genomic Locations for NAALADL1 Gene
chr11:65,044,818-65,059,021
(GRCh38/hg38)
Size:
14,204 bases
Orientation:
Minus strand
chr11:64,812,290-64,826,021
(GRCh37/hg19)

Genomic View for NAALADL1 Gene

Genes around NAALADL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAALADL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAALADL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAALADL1 Gene

Proteins for NAALADL1 Gene

  • Protein details for NAALADL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQQ1-NALDL_HUMAN
    Recommended name:
    N-acetylated-alpha-linked acidic dipeptidase-like protein
    Protein Accession:
    Q9UQQ1
    Secondary Accessions:
    • C9J8A1
    • C9J964
    • C9JL35
    • C9JSN0
    • O43176

    Protein attributes for NAALADL1 Gene

    Size:
    740 amino acids
    Molecular mass:
    80558 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB87645.1; Type=Frameshift; Positions=686, 693; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAALADL1 Gene

    Alternative splice isoforms for NAALADL1 Gene

neXtProt entry for NAALADL1 Gene

Post-translational modifications for NAALADL1 Gene

  • Glycosylation at Asn136, posLast=274274, Asn299, posLast=334334, posLast=345345, posLast=451451, and Asn492
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAALADL1 Gene

Domains & Families for NAALADL1 Gene

Gene Families for NAALADL1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NAALADL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQQ1

UniProtKB/Swiss-Prot:

NALDL_HUMAN :
  • Belongs to the peptidase M28 family. M28B subfamily.
Family:
  • Belongs to the peptidase M28 family. M28B subfamily.
genes like me logo Genes that share domains with NAALADL1: view

Function for NAALADL1 Gene

Molecular function for NAALADL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
UniProtKB/Swiss-Prot Function:
NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).

Enzyme Numbers (IUBMB) for NAALADL1 Gene

Phenotypes From GWAS Catalog for NAALADL1 Gene

Gene Ontology (GO) - Molecular Function for NAALADL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0008233 peptidase activity NAS 9388249
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with NAALADL1: view
genes like me logo Genes that share phenotypes with NAALADL1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAALADL1 Gene

Localization for NAALADL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAALADL1 Gene

Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAALADL1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAALADL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9388249
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with NAALADL1: view

Pathways & Interactions for NAALADL1 Gene

SuperPathways for NAALADL1 Gene

No Data Available

Interacting Proteins for NAALADL1 Gene

Gene Ontology (GO) - Biological Process for NAALADL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAALADL1: view

No data available for Pathways by source and SIGNOR curated interactions for NAALADL1 Gene

Drugs & Compounds for NAALADL1 Gene

(1) Drugs for NAALADL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Danazol Approved Pharma 16
genes like me logo Genes that share compounds with NAALADL1: view

Transcripts for NAALADL1 Gene

Unigene Clusters for NAALADL1 Gene

N-acetylated alpha-linked acidic dipeptidase-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAALADL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - -
SP7:
SP8: - - -
SP9: - - -
SP10: - - - -

ExUns: 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NAALADL1 Gene

GeneLoc Exon Structure for
NAALADL1
ECgene alternative splicing isoforms for
NAALADL1

Expression for NAALADL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAALADL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAALADL1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x17.5).

Protein differential expression in normal tissues from HIPED for NAALADL1 Gene

This gene is overexpressed in Colon muscle (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAALADL1 Gene



Protein tissue co-expression partners for NAALADL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAALADL1 Gene:

NAALADL1

SOURCE GeneReport for Unigene cluster for NAALADL1 Gene:

Hs.13967

mRNA Expression by UniProt/SwissProt for NAALADL1 Gene:

Q9UQQ1-NALDL_HUMAN
Tissue specificity: Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon.

Evidence on tissue expression from TISSUES for NAALADL1 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with NAALADL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAALADL1 Gene

Orthologs for NAALADL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAALADL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAALADL1 33 34
  • 98.69 (n)
dog
(Canis familiaris)
Mammalia NAALADL1 33 34
  • 84.5 (n)
cow
(Bos Taurus)
Mammalia NAALADL1 33 34
  • 84.3 (n)
rat
(Rattus norvegicus)
Mammalia Naaladl1 33
  • 81.44 (n)
mouse
(Mus musculus)
Mammalia Naaladl1 33 16 34
  • 81.08 (n)
oppossum
(Monodelphis domestica)
Mammalia NAALADL1 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NAALADL1 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487005 33
  • 60.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24489 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-214j8.1 33
  • 57.97 (n)
NAALADL1 34
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gcp-2.1 34
  • 29 (a)
ManyToMany
gcp-2.2 34
  • 29 (a)
ManyToMany
gcp-2.3 34
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS70 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3946 34
  • 34 (a)
OneToOne
Species where no ortholog for NAALADL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAALADL1 Gene

ENSEMBL:
Gene Tree for NAALADL1 (if available)
TreeFam:
Gene Tree for NAALADL1 (if available)

Paralogs for NAALADL1 Gene

Paralogs for NAALADL1 Gene

genes like me logo Genes that share paralogs with NAALADL1: view

Variants for NAALADL1 Gene

Sequence variations from dbSNP and Humsavar for NAALADL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000034452 -- 65,050,755(+) CTGCA(C/G)TCCAG intron-variant
rs1000120658 -- 65,060,876(+) TCCCA(A/G)TGGCT downstream-variant-500B, upstream-variant-2KB
rs1000149375 -- 65,059,433(+) TAAGG(C/T)CTAGA upstream-variant-2KB
rs1000181084 -- 65,050,197(+) TGTGG(G/T)GGCTG intron-variant
rs1000196767 -- 65,057,115(+) TTAGA(C/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAALADL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680
nsv1150491 CNV insertion 26484159

Variation tolerance for NAALADL1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAALADL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAALADL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAALADL1 Gene

Disorders for NAALADL1 Gene

Relevant External Links for NAALADL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAALADL1

No disorders were found for NAALADL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAALADL1 Gene

Publications for NAALADL1 Gene

  1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PMID: 10085079) Pangalos MN … Gordon RD (The Journal of biological chemistry 1999) 2 3 4 60
  2. Cloning and characterization of a novel peptidase from rat and human ileum. (PMID: 9388249) Shneider BL … Ananthanarayanan M (The Journal of biological chemistry 1997) 3 4 22 60
  3. Structural and biochemical characterization of a novel aminopeptidase from human intestine. (PMID: 25752612) Tykvart J … Konvalinka J (The Journal of biological chemistry 2015) 3 60
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for NAALADL1 Gene

Sources for NAALADL1 Gene