Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAALADL1 Gene

protein-coding   GIFtS: 51
GCID: GC11M064812

N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 11 2     NAALADASEL2 3
I1002 3 5     NAALADase L2 3
Ileal Peptidase I1001 2     N-Acetylated-Alpha-Linked Acidic Dipeptidase-Like Protein2
Ileal Dipeptidylpeptidase2 3     EC 3.4.17.213
100 KDa Ileum Brush Border Membrane Protein2 3     NAALADL3

External Ids:    HGNC: 235361   Entrez Gene: 100042   Ensembl: ENSG000001680607   OMIM: 6026405   UniProtKB: Q9UQQ13   

Export aliases for NAALADL1 gene to outside databases

Previous GC identifers: GC11M064588 GC11M064569 GC11M061139


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NAALADL1 Gene: 
NAALADL1 (N-acetylated alpha-linked acidic dipeptidase-like 1) is a protein-coding gene. Diseases associated with NAALADL1 include multinodular goiter, and goiter. GO annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is NAALADL2.

UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1
Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV
type activity. In vitro, cleaves Gly-Pro-AMC (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAALADL1 gene promoter:
         STAT1   NF-1   STAT3   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAALADL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAALADL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAALADL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12

NAALADL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAALADL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064812:  view genomic region     (about GC identifiers)

Start:
64,812,290 bp from pter      End:
64,826,021 bp from pter
Size:
13,732 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1 (See protein sequence)
Recommended Name: N-acetylated-alpha-linked acidic dipeptidase-like protein  
Size: 740 amino acids; 80558 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subcellular location: Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane
Sequence caution: Sequence=AAB87645.1; Type=Frameshift; Positions=686, 693;
Secondary accessions: C9J8A1 C9J964 C9JL35 C9JSN0 O43176
Alternative splicing: 8 isoforms:  Q9UQQ1-1   Q9UQQ1-2   Q9UQQ1-3   Q9UQQ1-4   Q9UQQ1-5   Q9UQQ1-6   Q9UQQ1-7   Q9UQQ1-8   

Explore the universe of human proteins at neXtProt for NAALADL1: NX_Q9UQQ1

Explore proteomics data for NAALADL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UQQ1

  • NAALADL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAALADL1 Protein Expression
    REFSEQ proteins: NP_005459.2  
    ENSEMBL proteins: 
     ENSP00000434225   ENSP00000435917   ENSP00000351484   ENSP00000431977   ENSP00000344244  
     ENSP00000347955   ENSP00000349045   ENSP00000433538   ENSP00000435267   ENSP00000431322  
     ENSP00000435549   ENSP00000433892   ENSP00000431513   ENSP00000434233   ENSP00000347530  
     ENSP00000340111  

    Human Recombinant Protein Products for NAALADL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NAALADL1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for NAALADL1 
    OriGene Custom Protein Services for NAALADL1
    GenScript Custom Purified and Recombinant Proteins Services for NAALADL1
    Sino Biological Recombinant Protein for NAALADL1
    Sino Biological Cell Lysate for NAALADL1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NAALADL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS9388249
    GO:0016324apical plasma membrane IEA--

    NAALADL1 for ontologies           About GeneDecksing



    NAALADL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NAALADL1 (NAALADase-like 1/NAALADL1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NAALADL1
    GenScript Custom Superior Antibodies Services for NAALADL1
    Novus Biologicals NAALADL1 Antibody
    Abcam antibodies for NAALADL1
    Cloud-Clone Corp. Antibodies for NAALADL1 
    Search ThermoFisher Antibodies for NAALADL1
    LSBio Antibodies in human, mouse, rat for NAALADL1 

    Assay Products for NAALADL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAALADL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAALADL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAALADL1 
    Cloud-Clone Corp. CLIAs for NAALADL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: N-Acetylated I+--linked acidic dipeptidase-like 1 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003137 Protease-assoc_domain
     IPR007484 Peptidase_M28
     IPR007365 TFR-like_dimer_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQQ1

    ProtoNet protein and cluster: Q9UQQ1

    3 Blocks protein domains:
    IPB003137 Protease-associated PA
    IPB007365 Transferrin receptor-like dimerisation domain
    IPB007484 Peptidase family M28


    UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1
    Similarity: Belongs to the peptidase M28 family. M28B subfamily


    NAALADL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NALDL_HUMAN, Q9UQQ1
    Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV
    type activity. In vitro, cleaves Gly-Pro-AMC (By similarity)
    Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or
    folylpoly-gamma-glutamates

         Enzyme Number (IUBMB): EC 3.4.17.211

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity IEA--
    GO:0008233peptidase activity NAS9388249
    GO:0008237metallopeptidase activity IEA--
    GO:0016805dipeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    NAALADL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAALADL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAALADL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAALADL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAALADL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAALADL1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NAALADL1:
    hsa-miR-100* hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAALADL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAALADL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAALADL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAALADL1
    Sirion Biotech Customized adenovirus for overexpression of NAALADL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NAALADL1 (see all 7)
    OriGene ORF clones in mouse, rat for NAALADL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAALADL1 (NM_005468)
    Sino Biological Human cDNA Clone for NAALADL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAALADL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAALADL1
    Sirion Biotech Customized lentivirus for stable overexpression of NAALADL1 
                         Customized lentivirus expression plasmids for stable overexpression of NAALADL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAALADL1
    Search LifeMap BioReagents cell lines for NAALADL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALADL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAALADL1

    1 Interacting protein for NAALADL1 (Q9UQQ13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANPEPP151443I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    NAALADL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAALADL1 (NALDL)

    1 HMDB Compound for NAALADL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Danazol(17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16)17230-88-5--

    Search CenterWatch for drugs/clinical trials and news about NAALADL1 / NALDL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAALADL1 gene: 
    NM_005468.2  

    Unigene Cluster for NAALADL1:

    N-acetylated alpha-linked acidic dipeptidase-like 1
    Hs.13967  [show with all ESTs]
    Unigene Representative Sequence: NM_005468
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000533753 ENST00000532450 ENST00000358658(uc001ocn.3 uc010rnw.2)
    ENST00000526799 ENST00000529274 ENST00000528977 ENST00000340252 ENST00000355721
    ENST00000356632 ENST00000526516 ENST00000532802 ENST00000530995 ENST00000533842
    ENST00000534568 ENST00000533340 ENST00000531746 ENST00000528884(uc009ypz.3)
    ENST00000531174
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAALADL1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NAALADL1:
    hsa-miR-100* hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAALADL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAALADL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAALADL1
    Clone
    Products:
         
    OriGene clones in human, mouse for NAALADL1 (see all 7)
    OriGene ORF clones in mouse, rat for NAALADL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAALADL1 (NM_005468)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAALADL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAALADL1
    Sirion Biotech Customized lentivirus for stable overexpression of NAALADL1 
                         Customized lentivirus expression plasmids for stable overexpression of NAALADL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NAALADL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAALADL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAALADL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAALADL1

    Additional mRNA sequence: 

    AF001547.1 AF010141.1 AJ012371.1 AK309536.1 AK311090.1 BC143643.1 BC143644.1 

    7 DOTS entries:

    DT.401313  DT.120710133  DT.99972116  DT.40131683  DT.95154328  DT.95342236  DT.120710109 

    24/49 AceView cDNA sequences (see all 49):

    AA504367 BP379466 BX099491 AW170591 BM726624 AI285158 AI783670 BU743082 
    CD514468 BU741137 BM682839 AA932859 BM681269 CA308506 BM719523 AI868903 
    CB048466 BQ723610 AA861691 BP381256 AA612970 BF056631 AW135808 BF508363 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAALADL1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
    SP1:                                                  -     -     -                       -     -                       -                                       
    SP2:                                                                                                        -           -                                       
    SP3:                                                                                -     -     -           -     -     -                                       
    SP4:                                                                                      -     -           -     -     -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 17 ^ 18a · 18b · 18c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for NAALADL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAALADL1 expression in normal human tissues (normalized intensities)      NAALADL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGTATCC
    NAALADL1 Expression
    About this image


    NAALADL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See NAALADL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAALADL1

    SOURCE GeneReport for Unigene cluster: Hs.13967

    UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1
    Tissue specificity: Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak
    expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2
    and 3 isoform 3 are found in the small intestine and colon

        SABiosciences Custom PCR Arrays for NAALADL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NAALADL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAALADL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAALADL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAALADL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALADL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAALADL1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naaladl11 , 5 N-acetylated alpha-linked acidic dipeptidase-like 11, 5 81.08(n)1
    81.89(a)1
      19 (4.34 cM)5
    3812041  NM_001009546.11  NP_001009546.11 
     61057825 
    lizard
    (Anolis carolinensis)
    Reptilia NAALADL16
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343520.1(290486-314805)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244892 Xenopus laevis cDNA clone IMAGE6878980, containing more 72(n)    BC054987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-214j8.11 si:ch211-214j8.1 57.81(n)
    56.71(a)
      100000223  NM_001098190.1  NP_001091660.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R57.16
    C35C5.26
    (see all 3)
    Protein C35C5.2
    (see all 3)
    29(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(301832-308296)
    X(11537714-11541417)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS706
    Protein of unknown function involved in vacuolar p...
    17(a)
    1 → many
    X(656254-658689)


    ENSEMBL Gene Tree for NAALADL1 (if available)
    TreeFam Gene Tree for NAALADL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAALADL1 gene
    NAALADL22  TFRC2  FOLH12  TFR22  NAALAD22  
    4 SIMAP similar genes for NAALADL1 using alignment to 13 protein entries:     NALDL_HUMAN (see all proteins):
    FOLH1B    FOLH1    NAALAD2    TFRC

    NAALADL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/424 SNPs in NAALADL1 are shown (see all 424)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411289561,2
    Cuntested164824871(+) CATATC/TGAGTC 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs351247991,2
    C,F--64812857(+) TCCCTG/AGCCCT 2 /A syn17Minor allele frequency- A:0.06NA CSA WA EA EU 5738
    rs2013737431,2
    --64812898(+) GACTAC/TGGAGC 2 I V mis10--------
    rs2004197451,2
    --64812906(+) AGCCCA/GTGCGA 2 T M mis10--------
    rs3739914261,2
    C--64812939(+) CAAGAG/TAAATG 1 -- int10--------
    rs1486991721,2
    C--64813085(+) GTGGC-/GGGTCG 1 -- int10--------
    rs1849454271,2
    --64813089(+) GCGGTC/TGGGGG 1 -- int10--------
    rs1130770331,2
    C--64813250(+) TGTCCG/AGCCCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1394614391,2
    C,F--64813304(+) GTAGCG/ATTCCT 2 /R /C mis11Minor allele frequency- A:0.00NA 4544
    rs1449885521,2
    C,F--64813307(+) GCGTTC/TCTCTG 2 K E mis11Minor allele frequency- T:0.00NA 4544

    HapMap Linkage Disequilibrium report for NAALADL1 (64812290 - 64826021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NAALADL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NAALADL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NAALADL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602640    OMIM disorders: --

    3 diseases for NAALADL1:    About MalaCards
    multinodular goiter    goiter    thyroiditis


    NAALADL1 for disorders           About GeneDecksing


    Export disorders for NAALADL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAALADL1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NAALADL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PubMed id 10085079)1, 2, 3 Pangalos M.N.... Gordon R.D. (1999)
    2. Cloning and characterization of a novel peptidase from rat and human ileum. (PubMed id 9388249)1, 2, 9 Shneider B.L.... Ananthanarayanan M. (1997)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10004 HGNC: 23536 AceView: NAALADL1 Ensembl:ENSG00000168060 euGenes: HUgn10004
    ECgene: NAALADL1 H-InvDB: NAALADL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAALADL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAALADL1 gene:
    Search GeneIP for patents involving NAALADL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NAALADL1 (NAALADase-like 1/NAALADL1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NAALADL1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for NAALADL1   OriGene clones in human, mouse for NAALADL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NAALADL1   OriGene Purified Protein for NAALADL1  
     OriGene ORF clones in mouse, rat for NAALADL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NAALADL1   OriGene Custom Protein Services for NAALADL1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAALADL1
     QIAGEN SeqTarget long-range PCR primers for resequencing NAALADL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAALADL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAALADL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAALADL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAALADL1
     GenScript Custom Purified and Recombinant Proteins Services for NAALADL1 GenScript cDNA clones with any tag delivered in your preferred vector for NAALADL1
     GenScript Custom Assay Services for NAALADL1 GenScript Custom Superior Antibodies Services for NAALADL1
     GenScript Custom overexpressing Cell Line Services for NAALADL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NAALADL1 promoter
     Search Chromatin IP Primers for NAALADL1
     RT2 qPCR Primer Assay in human, mouse, rat NAALADL1
     Search GNC Networks for NAALADL1
     SABiosciences Custom PCR Arrays for NAALADL1
     Search Tocris compounds for NAALADL1 (NALDL)
     Proteins and Antibodies for NAALADL1
     Cell Lysates for NAALADL1
     cDNA Clones for NAALADL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NAALADL1 antibodies
     Antibodies for NAALADL1
     See all of Abcam's Antibodies, Kits and Proteins for NAALADL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NAALADL1
     Antibodies for NAALADL1
     ELISAs for NAALADL1
     CLIAs for NAALADL1
     Search LifeMap BioReagents cell lines for NAALADL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALADL1
     SwitchGear 3'UTR luciferase reporter plasmids for NAALADL1
     SwitchGear Promoter luciferase reporter plasmids for NAALADL1
     Search ThermoFisher Antibodies for NAALADL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAALADL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NAALADL1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAALADL1
    Customized:
     lentivirus for stable overexpression of NAALADL1
     lentivirus expression plasmids for stable overexpression of NAALADL1
     adenovirus for overexpression of NAALADL1
     LSBio Antibodies in human, mouse, rat for NAALADL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 27 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NAALADL1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4