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Aliases for NAALADL1 Gene

Aliases for NAALADL1 Gene

  • N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 1 2 3 5
  • 100 KDa Ileum Brush Border Membrane Protein 3 4
  • Ileal Dipeptidylpeptidase 3 4
  • Ileal Peptidase I100 2 3
  • NAALADase L 3 4
  • I100 3 4
  • EC 4

External Ids for NAALADL1 Gene

Previous GeneCards Identifiers for NAALADL1 Gene

  • GC11M064588
  • GC11M064569
  • GC11M064812
  • GC11M061139

Summaries for NAALADL1 Gene

GeneCards Summary for NAALADL1 Gene

NAALADL1 (N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 1) is a Protein Coding gene. GO annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is FOLH1.

UniProtKB/Swiss-Prot for NAALADL1 Gene

  • NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAALADL1 Gene

Genomics for NAALADL1 Gene

Regulatory Elements for NAALADL1 Gene

Transcription factor binding sites by QIAGEN in the NAALADL1 gene promoter:

Genomic Location for NAALADL1 Gene

65,044,818 bp from pter
65,059,021 bp from pter
14,204 bases
Minus strand

Genomic View for NAALADL1 Gene

Genes around NAALADL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAALADL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAALADL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAALADL1 Gene

Proteins for NAALADL1 Gene

  • Protein details for NAALADL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-acetylated-alpha-linked acidic dipeptidase-like protein
    Protein Accession:
    Secondary Accessions:
    • C9J8A1
    • C9J964
    • C9JL35
    • C9JSN0
    • O43176

    Protein attributes for NAALADL1 Gene

    740 amino acids
    Molecular mass:
    80558 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • Sequence=AAB87645.1; Type=Frameshift; Positions=686, 693; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAALADL1 Gene

    Alternative splice isoforms for NAALADL1 Gene

neXtProt entry for NAALADL1 Gene

Proteomics data for NAALADL1 Gene at MOPED

Post-translational modifications for NAALADL1 Gene

  • Glycosylation at Asn 136, Asn 274, Asn 299, Asn 334, Asn 345, Asn 451, and Asn 492
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for NAALADL1 (NAALADase-like 1/NAALADL1)

No data available for DME Specific Peptides for NAALADL1 Gene

Domains & Families for NAALADL1 Gene

Gene Families for NAALADL1 Gene

Suggested Antigen Peptide Sequences for NAALADL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M28 family. M28B subfamily.
  • Belongs to the peptidase M28 family. M28B subfamily.
genes like me logo Genes that share domains with NAALADL1: view

Function for NAALADL1 Gene

Molecular function for NAALADL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
UniProtKB/Swiss-Prot Function:
NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).

Enzyme Numbers (IUBMB) for NAALADL1 Gene

Gene Ontology (GO) - Molecular Function for NAALADL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with NAALADL1: view
genes like me logo Genes that share phenotypes with NAALADL1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAALADL1 Gene

Localization for NAALADL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAALADL1 Gene

Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane.

Subcellular locations from

Jensen Localization Image for NAALADL1 Gene COMPARTMENTS Subcellular localization image for NAALADL1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NAALADL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with NAALADL1: view

Pathways & Interactions for NAALADL1 Gene

SuperPathways for NAALADL1 Gene

No Data Available

Interacting Proteins for NAALADL1 Gene

Gene Ontology (GO) - Biological Process for NAALADL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NAALADL1 Gene

Drugs & Compounds for NAALADL1 Gene

(1) Drugs for NAALADL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Danazol Approved Pharma 15
genes like me logo Genes that share compounds with NAALADL1: view

Transcripts for NAALADL1 Gene

Unigene Clusters for NAALADL1 Gene

N-acetylated alpha-linked acidic dipeptidase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAALADL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - -
SP8: - - -
SP9: - - -
SP10: - - - -

ExUns: 17 ^ 18a · 18b · 18c

Relevant External Links for NAALADL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAALADL1 Gene

mRNA expression in normal human tissues for NAALADL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAALADL1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x17.5).

Protein differential expression in normal tissues from HIPED for NAALADL1 Gene

This gene is overexpressed in Colon muscle (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAALADL1 Gene

SOURCE GeneReport for Unigene cluster for NAALADL1 Gene Hs.13967

mRNA Expression by UniProt/SwissProt for NAALADL1 Gene

Tissue specificity: Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon.
genes like me logo Genes that share expression patterns with NAALADL1: view

Protein tissue co-expression partners for NAALADL1 Gene

Primer Products

In Situ Assay Products

Orthologs for NAALADL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAALADL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAALADL1 35
  • 84.3 (n)
  • 83.22 (a)
  • 83 (a)
(Canis familiaris)
Mammalia NAALADL1 35
  • 84.5 (n)
  • 85.25 (a)
  • 89 (a)
(Mus musculus)
Mammalia Naaladl1 35
  • 81.08 (n)
  • 81.89 (a)
Naaladl1 16
Naaladl1 36
  • 81 (a)
(Pan troglodytes)
Mammalia NAALADL1 35
  • 98.69 (n)
  • 98.31 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Naaladl1 35
  • 81.44 (n)
  • 80.95 (a)
(Monodelphis domestica)
Mammalia NAALADL1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
(Anolis carolinensis)
Reptilia NAALADL1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487005 35
  • 60.35 (n)
  • 57.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24489 35
(Danio rerio)
Actinopterygii si:ch211-214j8.1 35
  • 57.97 (n)
  • 56.56 (a)
  • 56 (a)
(Caenorhabditis elegans)
Secernentea gcp-2.1 36
  • 29 (a)
gcp-2.2 36
  • 29 (a)
gcp-2.3 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS70 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3946 36
  • 34 (a)
Species with no ortholog for NAALADL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAALADL1 Gene

Gene Tree for NAALADL1 (if available)
Gene Tree for NAALADL1 (if available)

Paralogs for NAALADL1 Gene

Paralogs for NAALADL1 Gene

genes like me logo Genes that share paralogs with NAALADL1: view

Variants for NAALADL1 Gene

Sequence variations from dbSNP and Humsavar for NAALADL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35422506 - 65,058,516(+) GTCCA(C/G)TGCAT intron-variant, nc-transcript-variant, reference, missense
rs12223986 - 65,053,223(+) CCTTC(G/T)TCAGC nc-transcript-variant, reference, missense
rs36053340 - 65,046,213(+) CTCCA(C/G)CAGGG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs477539 -- 65,053,182(+) GGGGG(C/T)GAAGG intron-variant
rs488686 -- 65,046,953(+) TAATC(A/G)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAALADL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Variation tolerance for NAALADL1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAALADL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAALADL1 Gene

Disorders for NAALADL1 Gene

Relevant External Links for NAALADL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAALADL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAALADL1 Gene

Publications for NAALADL1 Gene

  1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PMID: 10085079) Pangalos M.N. … Gordon R.D. (J. Biol. Chem. 1999) 2 3 4 67
  2. Cloning and characterization of a novel peptidase from rat and human ileum. (PMID: 9388249) Shneider B.L. … Ananthanarayanan M. (J. Biol. Chem. 1997) 3 23
  3. Structural and biochemical characterization of a novel aminopeptidase from human intestine. (PMID: 25752612) Tykvart J. … Konvalinka J. (J. Biol. Chem. 2015) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for NAALADL1 Gene

Sources for NAALADL1 Gene

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