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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAALADL1 Gene

protein-coding   GIFtS: 49
GCID: GC11M064812

N-acetylated alpha-linked acidic dipeptidase-like 1

 Explore 5 diseases affiliated with
NAALADL1 via our new
 Human Malady Compendium 
Biological research products
for NAALADL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
N-Acetylated Alpha-Linked Acidic Dipeptidase-Like 11 2     NAALADase L2 3
I1002 3 5     Ileal Peptidase I1002
Ileal Dipeptidylpeptidase2 3     N-Acetylated-Alpha-Linked Acidic Dipeptidase-Like Protein2
100 KDa Ileum Brush Border Membrane Protein2 3     EC 3.4.17.213
NAALADASEL2 3     NAALADL3

External Ids:    HGNC: 235361   Entrez Gene: 100042   Ensembl: ENSG000001680607   OMIM: 6026405   UniProtKB: Q9UQQ13   

Export aliases for NAALADL1 gene to outside databases

Previous GC identifers: GC11M064588 GC11M064569 GC11M061139


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1
Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type
activity. In vitro, cleaves Gly-Pro-AMC (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAALADL1 gene promoter:
         STAT1   NF-1   STAT3   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAALADL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAALADL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAALADL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12

NAALADL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAALADL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064812:  view genomic region     (about GC identifiers)

Start:
64,812,290 bp from pter      End:
64,826,021 bp from pter
Size:
13,732 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1 (See protein sequence)
Recommended Name: N-acetylated-alpha-linked acidic dipeptidase-like protein  
Size: 740 amino acids; 80558 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subcellular location: Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane
Sequence caution: Sequence=AAB87645.1; Type=Frameshift; Positions=686, 693;
Secondary accessions: C9J8A1 C9J964 C9JL35 C9JSN0 O43176
Alternative splicing: 8 isoforms:  Q9UQQ1-1   Q9UQQ1-2   Q9UQQ1-3   Q9UQQ1-4   Q9UQQ1-5   Q9UQQ1-6   Q9UQQ1-7   Q9UQQ1-8   

Explore the universe of human proteins at neXtProt for NAALADL1: NX_Q9UQQ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQQ1

  • NAALADL1 Protein expression data from MOPED and PaxDb:    About this image 
    NAALADL1 Protein Expression
    REFSEQ proteins: NP_005459.2  
    ENSEMBL proteins: 
     ENSP00000434225   ENSP00000435917   ENSP00000351484   ENSP00000431977   ENSP00000344244  
     ENSP00000347955   ENSP00000349045   ENSP00000433538   ENSP00000435267   ENSP00000431322  
     ENSP00000435549   ENSP00000433892   ENSP00000431513   ENSP00000434233   ENSP00000347530  
     ENSP00000340111  

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    Uscn Proteins for NAALADL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS9388249
    GO:0016324apical plasma membrane IEA--

    NAALADL1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NAALADL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007484 Peptidase_M28
     IPR007365 TFR-like_dimer_dom
     IPR003137 Protease-assoc_domain

    Graphical View of Domain Structure for InterPro Entry Q9UQQ1

    ProtoNet protein and cluster: Q9UQQ1

    3 Blocks protein families:
    IPB003137 Protease-associated PA
    IPB007365 Transferrin receptor-like dimerisation domain
    IPB007484 Peptidase family M28


    UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1
    Similarity: Belongs to the peptidase M28 family. M28B subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NALDL_HUMAN, Q9UQQ1
    Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type
    activity. In vitro, cleaves Gly-Pro-AMC (By similarity)
    Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or
    folylpoly-gamma-glutamates

         Enzyme Number (IUBMB): EC 3.4.17.211

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity IEA--
    GO:0008233peptidase activity NAS9388249
    GO:0008237metallopeptidase activity IEA--
    GO:0016805dipeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    NAALADL1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAALADL1

    1 Interacting protein for NAALADL1 (Q9UQQ13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANPEPP151443I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    NAALADL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NAALADL1

    1 HMDB Compound for NAALADL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Danazol(17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16)17230-88-5--
    Search CenterWatch for drugs/clinical trials and news about NAALADL1 / NALDL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAALADL1 gene: 
    NM_005468.2  

    Unigene Cluster for NAALADL1:

    N-acetylated alpha-linked acidic dipeptidase-like 1
    Hs.13967  [show with all ESTs]
    Unigene Representative Sequence: NM_005468
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000533753 ENST00000532450 ENST00000358658(uc001ocn.3 uc010rnw.2)
    ENST00000526799 ENST00000529274 ENST00000528977 ENST00000340252 ENST00000355721
    ENST00000356632 ENST00000526516 ENST00000532802 ENST00000530995 ENST00000533842
    ENST00000534568 ENST00000533340 ENST00000531746 ENST00000528884(uc009ypz.3)
    ENST00000531174

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    hsa-miR-100* hsa-miR-876-3p
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    Additional cDNA sequence: 

    AF001547.1 AF010141.1 AJ012371.1 AK309536.1 AK311090.1 BC143643.1 BC143644.1 

    7 DOTS entries:

    DT.401313  DT.120710133  DT.99972116  DT.40131683  DT.95154328  DT.95342236  DT.120710109 

    24/49 AceView cDNA sequences (see all 49):

    BP379466 BM726624 AW170591 AI783670 BU743082 AI285158 BX099491 AA504367 
    CD514468 BM681269 AA932859 AJ012371 NM_005468 BF508363 BF056631 BU741137 
    BQ723610 AA861691 AW135808 AI244986 BP381256 BG757994 AI868903 CA308506 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAALADL1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
    SP1:                                                  -     -     -                       -     -                       -                                       
    SP2:                                                                                                        -           -                                       
    SP3:                                                                                -     -     -           -     -     -                                       
    SP4:                                                                                      -     -           -     -     -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 17 ^ 18a · 18b · 18c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for NAALADL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAALADL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTGTATCC
    NAALADL1 Expression
    About this image
    See NAALADL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAALADL1

    SOURCE GeneReport for Unigene cluster: Hs.13967

    UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1
    Tissue specificity: Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak
    expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3
    isoform 3 are found in the small intestine and colon

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALADL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAALADL1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia NAALADL16
    --
    62(a)
    1 ↔ 1
    GL343520.1(290486-314805)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244892 Xenopus laevis cDNA clone IMAGE6878980, containing more 72(n)    BC054987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-214j8.11 si:ch211-214j8.1 57.81(n)
    56.71(a)
      100000223  NM_001098190.1  NP_001091660.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R57.16
    C35C5.26
    (see all 3)
    --
    28(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(301832-308296)
    X(11537648-11541351)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G076706
    AT5G197406
    (see all 3)
    Peptidase M28 family protein
    (see all 3)
    36(a)
    32(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(4462911-4464347)
    5(6673933-6676859)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 4)
    peptidase, putative, expressed
    (see all 4)
    32(a)
    30(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(30921725-30926382)
    1(31064077-31069104)


    ENSEMBL Gene Tree for NAALADL1 (if available)
    TreeFam Gene Tree for NAALADL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAALADL1 gene
    NAALADL22  TFRC2  FOLH12  TFR22  NAALAD22  
    4 SIMAP similar genes for NAALADL1 using alignment to 13 protein entries:     NALDL_HUMAN (see all proteins):
    FOLH1B    FOLH1    NAALAD2    TFRC

    NAALADL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/310 NCBI SNPs in NAALADL1 are shown (see all 310    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411289561,2
    Cunknown64824871(+) CATATC/TGAGTC 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs1927616151,2
    --64812232(+) CAGGAA/CTGGGC 2 -- ds5001 ut310--------
    rs1837293781,2
    --64812304(+) TACCAG/TTCACT 2 -- ut31 int10--------
    rs1884471331,2
    --64812512(+) TTTTGC/TCATCC 2 -- ut31 int10--------
    rs1923551501,2
    C--64812721(+) GGGAGA/GGCTGA 2 -- ut31 int10--------
    rs353447891,2
    C,F,H--64812791(+) AGGGCT/CGTCAC 3 /T int1 syn18Minor allele frequency- C:0.00NS NA 5292
    rs351247991,2
    C,F--64812857(+) TCCCTG/AGCCCT 2 /A syn17Minor allele frequency- A:0.06NA CSA WA EA EU 5738
    rs2013737431,2
    --64812898(+) GACTAC/TGGAGC 2 I V mis10--------
    rs2004197451,2
    --64812906(+) AGCCCA/GTGCGA 2 T M mis10--------
    rs1486991721,2
    C--64813083(+) GTGGC-/GGGTCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NAALADL1 (64812290 - 64826021 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NAALADL1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NAALADL1 for disorders           About GeneDecksing

    OMIM gene information: 602640    OMIM disorders: --

    5 diseases for NAALADL1:    About MalaCards
    multinodular goiter    goiter    thyroid carcinoma    thyroiditis
    carcinoma


    Export disorders for NAALADL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAALADL1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NAALADL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PubMed id 10085079)1, 2, 3 Pangalos M.N.... Gordon R.D. (1999)
    2. Cloning and characterization of a novel peptidase from rat and human ileum. (PubMed id 9388249)1, 2, 9 Shneider B.L.... Ananthanarayanan M. (1997)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10004 HGNC: 23536 AceView: NAALADL1 Ensembl:ENSG00000168060 euGenes: HUgn10004
    ECgene: NAALADL1 H-InvDB: NAALADL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAALADL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAALADL1 gene:
    Search GeneIP for patents involving NAALADL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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