Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAALAD2 Gene

protein-coding   GIFtS: 53
GCID: GC11P089867

N-acetylated alpha-linked acidic dipeptidase 2
 Explore 6 diseases affiliated with
NAALAD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NAALAD2    

Aliases
for NAALAD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Acetylated Alpha-Linked Acidic Dipeptidase 21 2     N-Acetylated-Alpha-Linked Acidic Dipeptidase II2 3
GPCIII1 2     NAALADase II2 3
NAADALASE21 2     EC 3.4.17.213 8
NAALADASE21 2     N-Acetylated Alpha-Linked Acidic Dipeptidase II2
Glutamate Carboxypeptidase III2 3     N-Acetylated-Alpha-Linked Acidic Dipeptidase 22
GCPIII2 3     

External Ids:    HGNC: 145261   Entrez Gene: 100032   Ensembl: ENSG000000776167   OMIM: 6116365   UniProtKB: Q9Y3Q03   

Export aliases for NAALAD2 gene to outside databases

Previous GC identifers: GC11P092197 GC11P091374 GC11P090052 GC11P089555 GC11P089556 GC11P089508 GC11P085952


Summaries
for NAALAD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NAALAD2:
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative
member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of
prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves
N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in
the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral
membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to
mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
Function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase
IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate




Genomic Views
for NAALAD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAALAD2 gene promoter:
         NCX/Ncx   FOXD1   FOXD3   Pax-2   CUTL1   Pax-2a   Meis-1b   Pax-2b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAALAD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAALAD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAALAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3-q21   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3-q21

NAALAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAALAD2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P089867:  view genomic region     (about GC identifiers)

Start:
 89,864,683 bp from pter      End:
 89,926,062 bp from pter
Size:
 61,380 bases      Orientation:
 plus strand

Proteins
for NAALAD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0 (See protein sequence)
Recommended Name: N-acetylated-alpha-linked acidic dipeptidase 2  
Size: 740 amino acids; 83592 Da
Cofactor: Binds 2 zinc ions per subunit. Required for NAALADase activity
Subunit: Homodimer
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
4 PDB 3D structures from and Proteopedia for NAALAD2:
3FEC (3D)        3FED (3D)        3FEE (3D)        3FF3 (3D)    
Secondary accessions: B3KQR4 Q4VAM9

Explore the universe of human proteins at neXtProt for NAALAD2: NX_Q9Y3Q0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3Q0

    • 4/7 DME Specific Peptides for NAALAD2 (Q9Y3Q0) (see all 7)
     FYDPTFK  SFDSLFSAV  NDQLMLLER  ILYSDPADYF 

    NAALAD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005458.1  
    ENSEMBL proteins: 
     ENSP00000431989   ENSP00000432481   ENSP00000433710   ENSP00000320083   ENSP00000435249  
     ENSP00000365111   ENSP00000435670  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NAALAD2 (NAALADase-2/NAALAD2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NAALAD2
    OriGene Protein Over-expression Lysate: NAALAD2
    OriGene Custom Protein Services for NAALAD2 
    GenScript Custom Purified and Recombinant Proteins Services for NAALAD2
    Novus Biologicals NAALAD2 Protein
    Novus Biologicals NAALAD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NAALAD2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS10085079


    NAALAD2 for ontologies           About GeneDecksing



    NAALAD2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NAALAD2 (NAALADase-2/NAALAD2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NAALAD2 
    GenScript Custom Superior Antibodies Services for NAALAD2
    Search for Antibodies for NAALAD2 at Abcam  
    Uscn Antibodies for NAALAD2
    Search ThermoFisher Antibodies for NAALAD2

    Assay Products for NAALAD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAALAD2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NAALAD2

    Protein Domains /
    Families
    for NAALAD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NAALAD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007484 Peptidase_M28
     IPR007365 TFR-like_dimer_dom
     IPR003137 Protease-assoc_domain

    Graphical View of Domain Structure for InterPro Entry Q9Y3Q0

    ProtoNet protein and cluster: Q9Y3Q0

    3 Blocks protein families:
    IPB003137 Protease-associated PA
    IPB007365 Transferrin receptor-like dimerisation domain
    IPB007484 Peptidase family M28


    UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
    Domain: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the
    C-terminal
    Similarity: Belongs to the peptidase M28 family. M28B subfamily


    Function
    for NAALAD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
    Function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase
    IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate
    Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or
    folylpoly-gamma-glutamates
    Enzyme regulation: Inhibited by quisqualate

    Enzyme Number (IUBMB): EC 3.4.17.211 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NAALAD2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAALAD2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NAALAD2:
    hsa-miR-1276 hsa-miR-4251 hsa-miR-769-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NAALAD2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAALAD2 (see all 7)
    OriGene shRNA RFP: NAALAD2
    OriGene siRNA: NAALAD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAALAD2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NAALAD2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAALAD2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAALAD2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NAALAD2 (NM_005467)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAALAD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAALAD2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NAALAD2
    Search LifeMap BioReagents cell lines for NAALAD2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALAD2

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity NAS10085079
    GO:0008233peptidase activity ----
    GO:0008236serine-type peptidase activity NAS10085079
    GO:0008237metallopeptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity NAS10085079


    NAALAD2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NAALAD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAALAD2

    5/14 Interacting proteins for NAALAD2 (Q9Y3Q03) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNCP248633I2D: score=1 
    CDC34P494273I2D: score=1 
    ELP2Q6IA863I2D: score=1 
    MAD2L1Q132573I2D: score=1 
    MMS19Q96T763I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS10085079
    GO:0042135neurotransmitter catabolic process IEA--


    NAALAD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NAALAD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAALAD2
    Search CenterWatch for drugs/clinical trials and news about NAALAD2 / NALD2 

    Transcripts
    for NAALAD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NAALAD2 gene: 
    NM_005467.3  

    Unigene Cluster for NAALAD2:

    N-acetylated alpha-linked acidic dipeptidase 2
    Hs.503560  [show with all ESTs]
    Unigene Representative Sequence: NM_005467
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525497 ENST00000534061(uc001pdf.4 uc009yvx.3 uc009yvy.3)
    ENST00000527493(uc001pde.3) ENST00000529090 ENST00000524501(uc001pdd.2)
    ENST00000321955 ENST00000525171 ENST00000375944 ENST00000526637 ENST00000532691


    miRNA
    Products:             		 OriGene 3'-UTR Clone: NAALAD2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAALAD2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NAALAD2:
    hsa-miR-1276 hsa-miR-4251 hsa-miR-769-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NAALAD2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAALAD2 (see all 7)
    OriGene shRNA RFP: NAALAD2
    OriGene siRNA: NAALAD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAALAD2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAALAD2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAALAD2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NAALAD2 (NM_005467)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAALAD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAALAD2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAALAD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAALAD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAALAD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAALAD2

    Additional cDNA sequence: 

    AJ012370.1 AK075390.1 AL133614.1 BC027594.1 BC038840.1 BC067793.1 BC096316.3 BC096317.3 
    BC096318.3 BC099646.4 

    5 DOTS entries:

    DT.91678123  DT.100021398  DT.70104856  DT.120716399  DT.91678118 

    24/52 AceView cDNA sequences (see all 52):

    AL133614 AK075390 BX110170 BC027594 AI791615 CD242563 BQ188040 BQ652244 
    AW613993 BV194058 AI821470 AI082319 BI524108 AI139622 BC038840 BE701041 
    AI199807 BG185042 BU854265 BI600086 BI604177 AA424600 BU618706 BC067793 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NAALAD2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^
    SP1:                          -                                               -           -                       -           -           -     -           -   
    SP2:                          -                                                           -                                                                     
    SP3:                          -                                                                                                                                 
    SP4:                          -                                         -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -     -     -     -         
    SP5:                              


    ECgene alternative splicing isoforms for NAALAD2

    Expression
    for NAALAD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAALAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NAALAD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)

    See NAALAD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAALAD2

    SOURCE GeneReport for Unigene cluster: Hs.503560

    UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
    Tissue specificity: Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate,
    heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in
    hippocampus, brain stem, putamen and superior colliculus

        SABiosciences Custom PCR Arrays for NAALAD2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAALAD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAALAD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAALAD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAALAD2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALAD2

    Orthologs
    for NAALAD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAALAD2 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NAALAD21 N-acetylated alpha-linked acidic dipeptidase 2 73.07(n)
    74.42(a)    		   419010  XM_417204.3  XP_417204.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NAALAD26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 3(198725816-198755864)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.154622 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_005458.1 (H.sapiens) N-acetylated alpha-linked acidic dipeptidase 2; N-acetylated alpha-linked acidic dipeptidase II [Homo sapiens] less 76.67(n)    BU906541.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:564296
    		 zgc:56429
    		 66(a)
    		 1 → many
    		 15(42703278-42739302)
    worm
    (Caenorhabditis elegans)    		 Secernentea C35C5.23   -- 32(a)   X(11573200-11580288)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes VPS70(YJR126C)4
    VPS701    		 Protein of unknown function involved in vacuolar protein sorting less4
    Vps70p1    		 45.56(n)1
    33.46(a)1    		   10(658689-656254)4
    8535901, 4  NP_012660.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G197401 Peptidase M28 family protein 49.28(n)
    39.36(a)    		   832094  NM_121979.3  NP_197475.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.181452 Oryza sativa (japonica cultivar-group) cDNA clone002-105-D02, full insert sequence less 72.89(n)    AK103648.1 


    ENSEMBL Gene Tree for NAALAD2 (if available)
    TreeFam Gene Tree for NAALAD2 (if available) 

    Paralogs
    for NAALAD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAALAD2 gene
    NAALADL12  NAALADL22  TFRC2  FOLH12  TFR22  
    4 SIMAP similar genes for NAALAD2 using alignment to 9 protein entries:     NALD2_HUMAN (see all proteins):
    FOLH1B    FOLH1    NAALADL1    TFR2

    NAALAD2 for paralogs           About GeneDecksing


    5/12 Pseudogenes.org Pseudogenes for NAALAD2 (see all 12)
    PGOHUM00000238426 PGOHUM00000238745 PGOHUM00000258598 PGOHUM00000239102 PGOHUM00000246387


    Genomic Variants
    for NAALAD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1255 NCBI SNPs in NAALAD2 are shown (see all 1255)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1918665761,2
    		--89865823(+) ACATAA/CAAATA 1 -- us2k10--------
    rs770345891,2
    		F,--89865836(+) TCTGAG/ATGCTC 1 -- us2k13Minor allele frequency- A:0.06WA NA EA 358
    rs1415676131,2
    		--89865850(+) GAAAAC/TGTTTC 1 -- us2k10--------
    rs108304121,2
    		C,F,A,--89865952(+) ATGCAT/CATAAG 1 -- us2k14Minor allele frequency- C:0.20NA WA 242
    rs107413151,2
    		C,F,A,H,--89866017(+) AAATAG/AAAAAC 1 -- us2k112Minor allele frequency- A:0.49NA WA CSA EA 497
    rs745274381,2
    		--89866056(+) ACAGGC/ATAGTA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1845211481,2
    		--89866126(+) GTTCAC/TTAAGG 1 -- us2k10--------
    rs38089801,2
    		C,--89866143(-) AACTTT/CGAAGC 1 -- us2k13Minor allele frequency- C:0.18NA EA 242
    rs38089791,2
    		C,F,A,H,--89866154(-) ACCTGC/GTACTT 1 -- us2k110Minor allele frequency- G:0.48NA WA CSA EA 373
    rs38089781,2
    		C,F,A,H,--89866187(-) CTAATG/AACTTA 1 -- us2k118Minor allele frequency- A:0.49NA NS EA WA CSA 919

    HapMap Linkage Disequilibrium report for NAALAD2 (89864683 - 89926062 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NAALAD2
         3 CNVs: 85926 2943 3862

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAALAD2
    DNA2.0 Custom Variant and Variant Library Synthesis for NAALAD2

    Disorders / Diseases
    for NAALAD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NAALAD2 for disorders           About GeneDecksing

    OMIM gene information: 611636    OMIM disorders: --

    6 diseases for NAALAD2:    About MalaCards
    prostatitis    prostate carcinoma    colonic neoplasm    carcinoma
    homocysteine    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: NAALAD2 (1 document)

    Export disorders for NAALAD2 gene to outside databases

    Publications
    for NAALAD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAALAD2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with NAALAD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PubMed id 10085079)1, 2, 3, 9 Pangalos M.N.... Gordon R.D. (1999)
    2. Structural insight into the evolutionary and pharmaco logic homology of glutamate carboxypeptidases II and III. (PubMed id 19678840)1, 2 Hlouchova K....Lubkowski J. (2009)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)1 Okada Y....Kamatani N. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    8. Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. (PubMed id 12204797)1 Lievers K.J....Blom H.J. (2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II. (PubMed id 11905994)1 Barinka C....Konvalinka J. (2002)

    External Searches for NAALAD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NAALAD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10003 HGNC: 14526 AceView: NAALAD2 Ensembl:ENSG00000077616 euGenes: HUgn10003
    ECgene: NAALAD2 H-InvDB: NAALAD2

    Other Databases showing NAALAD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NAALAD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAALAD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAALAD2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NAALAD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NAALAD2 gene:
    Search GeneIP for patents involving NAALAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NAALAD2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NAALAD2 (NAALADase-2/NAALAD2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for NAALAD2 (NAALADase-2/NAALAD2)  
     Browse OriGene Antibodies   OriGene shRNA RFP for NAALAD2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAALAD2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAALAD2  
     OriGene Protein Over-expression Lysate for NAALAD2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NAALAD2   OriGene 3'-UTR Clone for NAALAD2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAALAD2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAALAD2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NAALAD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NAALAD2   OriGene Custom Protein Services for NAALAD2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAALAD2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAALAD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAALAD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAALAD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAALAD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAALAD2
     GenScript Custom Purified and Recombinant Proteins Services for NAALAD2 GenScript cDNA clones with any tag delivered in your preferred vector for NAALAD2
     GenScript Custom Assay Services for NAALAD2 GenScript Custom Superior Antibodies Services for NAALAD2
     GenScript Custom overexpressing Cell Line Services for NAALAD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NAALAD2 promoter
     Search Chromatin IP Primers for NAALAD2
     RT2 qPCR Primer Assay in human, mouse, rat NAALAD2
     Search GNC Networks for NAALAD2
     SABiosciences Custom PCR Arrays for NAALAD2
     Search Tocris compounds for NAALAD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NAALAD2 proteins
     NAALAD2 lysates
     Search for Antibodies for NAALAD2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NAALAD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NAALAD2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NAALAD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAALAD2
     SwitchGear 3'UTR luciferase reporter plasmids for NAALAD2
     SwitchGear Promoter luciferase reporter plasmids for NAALAD2
     Search ThermoFisher Antibodies for NAALAD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAALAD2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NAALAD2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4