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NAALAD2 Gene

protein-coding   GIFtS: 57
GCID: GC11P089867

N-Acetylated Alpha-Linked Acidic Dipeptidase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetylated Alpha-Linked Acidic Dipeptidase 21 2     GPCIII2
Glutamate Carboxypeptidase III1 2 3     NAADALASE22
GCPIII2 3     NAALADASE22
N-Acetylated-Alpha-Linked Acidic Dipeptidase II2 3     N-Acetylated Alpha-Linked Acidic Dipeptidase II2
NAALADase II2 3     N-Acetylated-Alpha-Linked Acidic Dipeptidase 22
EC 3.4.17.213 8     

External Ids:    HGNC: 145261   Entrez Gene: 100032   Ensembl: ENSG000000776167   OMIM: 6116365   UniProtKB: Q9Y3Q03   

Export aliases for NAALAD2 gene to outside databases

Previous GC identifers: GC11P092197 GC11P091374 GC11P090052 GC11P089555 GC11P089556 GC11P089508 GC11P085952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAALAD2 Gene:
This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The
representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which
is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves
N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems
and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II
integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV
activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain
areas. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAALAD2 Gene:
NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2) is a protein-coding gene. Diseases associated with NAALAD2 include prostatitis, and schizophrenia. GO annotations related to this gene include metallopeptidase activity and carboxypeptidase activity. An important paralog of this gene is NAALADL1.

UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
Function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a
dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAALAD2 gene promoter:
         NCX/Ncx   FOXD1   FOXD3   Pax-2   CUTL1   Pax-2a   Meis-1b   Pax-2b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAALAD2 promoter sequence
   Search Chromatin IP Primers for NAALAD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAALAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3-q21   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3-q21

NAALAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAALAD2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P089867:  view genomic region     (about GC identifiers)

Start:
89,864,683 bp from pter      End:
89,926,062 bp from pter
Size:
61,380 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0 (See protein sequence)
Recommended Name: N-acetylated-alpha-linked acidic dipeptidase 2  
Size: 740 amino acids; 83592 Da
Cofactor: Binds 2 zinc ions per subunit. Required for NAALADase activity
Subunit: Homodimer
4 PDB 3D structures from and Proteopedia for NAALAD2:
3FEC (3D)        3FED (3D)        3FEE (3D)        3FF3 (3D)    
Secondary accessions: B3KQR4 Q4VAM9

Explore the universe of human proteins at neXtProt for NAALAD2: NX_Q9Y3Q0

Explore proteomics data for NAALAD2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn111, Asn143, Asn185, Asn314, Asn449, Asn603, Asn628
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NAALAD2 (Q9Y3Q0) (see all 7)
     FYDPTFK  SFDSLFSAV  NDQLMLLER  ILYSDPADYF 


    See NAALAD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005458.1  
    ENSEMBL proteins: 
     ENSP00000431989   ENSP00000432481   ENSP00000433710   ENSP00000320083   ENSP00000435249  
     ENSP00000365111   ENSP00000435670  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: N-Acetylated I+--linked acidic dipeptidase 2
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR007365 TFR-like_dimer_dom
     IPR007484 Peptidase_M28
     IPR003137 Protease-assoc_domain

    Graphical View of Domain Structure for InterPro Entry Q9Y3Q0

    ProtoNet protein and cluster: Q9Y3Q0

    3 Blocks protein domains:
    IPB003137 Protease-associated PA
    IPB007365 Transferrin receptor-like dimerisation domain
    IPB007484 Peptidase family M28


    UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
    Domain: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the
    C-terminal
    Similarity: Belongs to the peptidase M28 family. M28B subfamily


    NAALAD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NALD2_HUMAN, Q9Y3Q0
    Function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a
    dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate
    Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or
    folylpoly-gamma-glutamates
    Enzyme regulation: Inhibited by quisqualate

         Enzyme Number (IUBMB): EC 3.4.17.211 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity NAS10085079
    GO:0008233peptidase activity ----
    GO:0008236serine-type peptidase activity NAS10085079
    GO:0008237metallopeptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity NAS10085079
         
    NAALAD2 for ontologies           About GeneDecksing


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    hsa-miR-1276 hsa-miR-4251 hsa-miR-769-5p
    SwitchGear 3'UTR luciferase reporter plasmidNAALAD2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NALD2_HUMAN, Q9Y3Q0: Membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS10085079

    NAALAD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAALAD2
    Interactions:

        Search GeneGlobe Interaction Network for NAALAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for NAALAD2 (Q9Y3Q03 ENSP000003200834) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNCP248633I2D: score=1 
    CDC34P494273I2D: score=1 
    ELP2Q6IA863I2D: score=1 
    MAD2L1Q132573I2D: score=1 
    MMS19Q96T763I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS10085079
    GO:0042135neurotransmitter catabolic process IEA--

    NAALAD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAALAD2 (NALD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAALAD2 gene: 
    NM_005467.3  

    Unigene Cluster for NAALAD2:

    N-acetylated alpha-linked acidic dipeptidase 2
    Hs.503560  [show with all ESTs]
    Unigene Representative Sequence: NM_005467
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525497 ENST00000534061(uc001pdf.4 uc009yvx.3 uc009yvy.3)
    ENST00000527493(uc001pde.3) ENST00000529090 ENST00000524501(uc001pdd.2)
    ENST00000321955 ENST00000525171 ENST00000375944 ENST00000526637 ENST00000532691

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    hsa-miR-1276 hsa-miR-4251 hsa-miR-769-5p
    SwitchGear 3'UTR luciferase reporter plasmidNAALAD2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat NAALAD2

    Additional mRNA sequence: 

    AJ012370.1 AK075390.1 AL133614.1 BC027594.1 BC038840.1 BC067793.1 BC096316.3 BC096317.3 
    BC096318.3 BC099646.4 

    5 DOTS entries:

    DT.91678123  DT.100021398  DT.70104856  DT.120716399  DT.91678118 

    Selected AceView cDNA sequences (see all 52):

    AK075390 AL133614 CD242563 BX110170 AI791615 BC027594 BQ652244 BG185042 
    BI604177 AI082319 BI600086 BV194058 BC038840 AI139622 AI821470 AW613993 
    NM_005467 CD106541 AA424534 BE701041 BQ188040 AA424600 AI199807 BX106487 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAALAD2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^
    SP1:                          -                                               -           -                       -           -           -     -           -   
    SP2:                          -                                                           -                                                                     
    SP3:                          -                                                                                                                                 
    SP4:                          -                                         -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -     -     -     -         
    SP5:                              


    ECgene alternative splicing isoforms for NAALAD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAALAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NAALAD2 Expression
    About this image


    NAALAD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
    NAALAD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAALAD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503560

    UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0
    Tissue specificity: Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate,
    heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in
    hippocampus, brain stem, putamen and superior colliculus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAALAD2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naalad21 , 5 N-acetylated alpha-linked acidic dipeptidase 21, 5 84.82(n)1
    88.11(a)1
      9 (7.02 cM)5
    725601  NM_028279.31  NP_082555.21 
     183219515 
    chicken
    (Gallus gallus)
    Aves NAALAD21 N-acetylated alpha-linked acidic dipeptidase 2 73.07(n)
    74.42(a)
      419010  XM_417204.4  XP_417204.2 
    lizard
    (Anolis carolinensis)
    Reptilia NAALAD26
    N-acetylated alpha-linked acidic dipeptidase 2
    72(a)
    1 ↔ 1
    3(198725816-198755864)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154622 Xenopus laevis transcribed sequence with moderate similarity more 76.67(n)    BU906541.1 
    zebrafish
    (Danio rerio)
    Actinopterygii naalad26
    N-acetylated alpha-linked acidic dipeptidase 2
    66(a)
    1 → many
    15(42703278-42739299) ENSDARG00000021383
    worm
    (Caenorhabditis elegans)
    Secernentea C35C5.23
    R57.11
    R57.11 32(a)3
    49.93(n)1
    38.6(a)1
      X(11573200-11580288)3
    1803861  NM_075684.51  NP_508085.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS70(YJR126C)4 Protein of unknown function involved in vacuolar protein more   --   10(658689-656254) 853590  NP_012660.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G197401 AT5G19740 49.71(n)
    39.68(a)
      832094  NM_121979.3  NP_197475.2 
    rice
    (Oryza sativa)
    Liliopsida Os.181452 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.89(n)    AK103648.1 


    ENSEMBL Gene Tree for NAALAD2 (if available)
    TreeFam Gene Tree for NAALAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAALAD2 gene
    NAALADL12  NAALADL22  TFRC2  FOLH12  TFR22  
    4 SIMAP similar genes for NAALAD2 using alignment to 9 protein entries:     NALD2_HUMAN (see all proteins):
    FOLH1B    FOLH1    NAALADL1    TFR2

    NAALAD2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for NAALAD2 (see all 12)
    PGOHUM00000238426 PGOHUM00000238745 PGOHUM00000258598 PGOHUM00000239102 PGOHUM00000246387


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAALAD2 (see all 1499)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918665761,2
    C--89865823(+) ACATAA/CAAATA 1 -- us2k10--------
    rs770345891,2
    C,F--89865836(+) TCTGAG/ATGCTC 1 -- us2k13Minor allele frequency- A:0.06WA NA EA 358
    rs1415676131,2
    --89865850(+) GAAAAC/TGTTTC 1 -- us2k10--------
    rs108304121,2
    C,F,A--89865952(+) ATGCAT/CATAAG 1 -- us2k14Minor allele frequency- C:0.20NA WA 242
    rs107413151,2
    C,F,A,H--89866017(+) AAATAG/AAAAAC 1 -- us2k112Minor allele frequency- A:0.49NA WA CSA EA 497
    rs745274381,2
    C,F--89866056(+) ACAGGC/ATAGTA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1845211481,2
    --89866126(+) GTTCAC/TTAAGG 1 -- us2k10--------
    rs38089801,2
    C--89866143(-) AACTTT/CGAAGC 1 -- us2k13Minor allele frequency- C:0.18NA EA 242
    rs38089791,2
    C,F,A,H--89866154(-) ACCTGC/GTACTT 1 -- us2k110Minor allele frequency- G:0.48NA WA CSA EA 373
    rs38089781,2
    C,F,A,H--89866187(-) CTAATG/AACTTA 1 -- us2k118Minor allele frequency- A:0.49NA NS EA WA CSA 919

    HapMap Linkage Disequilibrium report for NAALAD2 (89864683 - 89926062 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NAALAD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1511526CNV Insertion17803354
    esv272147CNV Insertion20981092
    nsv898139CNV Loss21882294
    nsv898140CNV Loss21882294
    nsv898141CNV Loss21882294
    nsv468787CNV Loss19166990
    nsv898142CNV Gain21882294
    nsv898118CNV Gain21882294
    nsv898094CNV Gain21882294
    dgv412e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAALAD2
    DNA2.0 Custom Variant and Variant Library Synthesis for NAALAD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611636    OMIM disorders: --

    2 diseases for NAALAD2:    
    About MalaCards
    prostatitis    schizophrenia


    NAALAD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NAALAD2
    Human Genome Epidemiology (HuGE) Navigator: NAALAD2 (1 document)

    Export disorders for NAALAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAALAD2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with NAALAD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. (PubMed id 10085079)1, 2, 3, 9 Pangalos M.N.... Gordon R.D. (J. Biol. Chem. 1999)
    2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. (PubMed id 19678840)1, 2 Hlouchova K.... Lubkowski J. (FEBS J. 2009)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    8. Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C--&gt;T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. (PubMed id 12204797)1 Lievers K.J....Blom H.J. (Atherosclerosis 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II. (PubMed id 11905994)1 Barinka C....Konvalinka J. (J. Neurochem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10003 HGNC: 14526 AceView: NAALAD2 Ensembl:ENSG00000077616 euGenes: HUgn10003
    ECgene: NAALAD2 H-InvDB: NAALAD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAALAD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAALAD2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAALAD2 gene:
    Search GeneIP for patents involving NAALAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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