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Aliases & Descriptions for NAALAD2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.4.17.21 3 | | MGC116996 2 | | MGC26353 2 | | NAADALASE2 1, 2 | | NAALADASE2 1, 2 |
| | | Descriptions |
|---|
| N-acetylated alpha-linked acidic dipeptidase 2 2 | | N-acetylated alpha-linked acidic dipeptidase II 2 | | N-acetylated-alpha-linked acidic dipeptidase II 3 | | NAALADase II 3 |
|
| | Search outside databases for aliases for NAALAD2 genePrevious GC identifers: GC11P092197 GC11P091374 GC11P090052 GC11P089555 GC11P089556 |
Summaries for NAALAD2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAALAD2: This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. [provided by RefSeq] UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0Function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate |
Genomic Location for NAALAD2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAALAD2 gene 
Entrez Gene cytogenetic band: 11q14.3-q21 Ensembl cytogenetic band: 11q14.3 HGNC cytogenetic band: 11q14.3-q21NAALAD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P089508:
(about GC identifiers)
Start:
|
89,507,491 bp from pter |
End:
|
89,565,424 bp from pter |
Size:
|
57,934 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_008984.17
| Proteins for NAALAD2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0 (See
protein sequence)Recommended Name: N-acetylated-alpha-linked acidic dipeptidase 2 Size: 740 amino acids; 83592 Da
Cofactor: Binds 2 zinc ions per subunit. Required for NAALADase activity
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: Q4VAM9REFSEQ proteins: NP_005458.1
ENSEMBL proteins: ENSP00000320083 ENSP00000365111
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NAALAD2: Assays for NAALAD2: | Protein
Domains/ Families for NAALAD2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y3Q0
ProtoNet protein and cluster: Q9Y3Q0 3 Blocks protein families: IPB003137 Protease-associated PA IPB007365 Transferrin receptor-like dimerisation domain IPB007484 Peptidase family M28
UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0Domain: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminalSimilarity: Belongs to the peptidase M28 family. M28B subfamily | Gene Function for NAALAD2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005467
Applied Biosystems Silencer® siRNAs for NAALAD2
Sigma-Aldrich siRNA and siRNA Panels for NAALAD2  Sigma-Aldrich shRNA for NAALAD2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005467                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005467                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005467 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005467
UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0Function: Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamateCatalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamatesEnzyme regulation: Inhibited by quisqualateEnzyme Number (IUBMB): EC 3.4.17.21 5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8
): About this table | Pathways & Interactions for NAALAD2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for NAALAD2 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for NAALAD2 (ENSP000003200833) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for NAALAD2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAALAD2
|
Transcripts for NAALAD2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005467
Sigma-Aldrich siRNA and siRNA Panels for NAALAD2  Sigma-Aldrich shRNA for NAALAD2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005467 REFSEQ mRNAs for NAALAD2 gene: NM_005467.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005467               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005467                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005467                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005467  Additional cDNA sequence: AJ012370.1 AK075390.1 AL133614.1 BC027594.1 BC038840.1 BC067793.1 BC096316.3 BC096317.3 BC096318.3 BC099646.4 5 DOTS entries: DT.91678123 DT.100021398 DT.70104856 DT.120716399 DT.91678118 24/52 AceView cDNA sequences (see all 52
):AI791615 BX110170 AK075390 AL133614 BC027594 CD242563 BC038840 BI524108 BQ188040 AI698592 CD106541 BI597780 AI199807 AJ012370 BI600086 AI139622 BX106487 BI598148 BU854265 NM_005467 BC067793 BV207937 BV194058 AW573201
highest scoring ESTs for NAALAD2:AJ012370 AK075390 BG185042 BQ438706 BU618706 BU854265 CD242563 AA424534 AA424600 AA973124 Unigene Cluster for NAALAD2: N-acetylated alpha-linked acidic dipeptidase 2 Hs.503560 [show with all ESTs]Unigene Representative Sequence: NM_005467
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NAALAD2 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | - |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |
| SP4: | - |   | - |   | - |   | - |   | |   | |
| SP5: | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAALAD2
2 Ensembl transcripts including schematic representations: ENST00000321955
ENST00000375944
|
Expression for NAALAD2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAALAD2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAALAD2
1 / 2 / 3 7 probe-sets matching NAALAD2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.503560
Expression variation in blood from EXPOLDB for NAALAD2 UniProtKB/Swiss-Prot: NALD2_HUMAN, Q9Y3Q0Tissue specificity: Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, putamen and superior colliculus |
Orthologs for NAALAD2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAALAD2 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for NAALAD2
ENSEMBL Gene Tree for NAALAD2 | Paralogs for NAALAD2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAALAD2 gene
- NAALADL12 FOLH12 ENSG000001346122
|
SNPs/Variants for NAALAD2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAALAD2 (up to first 250kb)
|
Disorders & Mutations for NAALAD2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611636
|
Medical News for NAALAD2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAALAD2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for NAALAD2 gene: |
Search for NAALAD2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAALAD2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAALAD2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAALAD2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAALAD2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAALAD2:

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Incremental update: 13 Oct 2009
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