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Aliases for NAAA Gene

Aliases for NAAA Gene

  • N-Acylethanolamine Acid Amidase 2 3
  • ASAHL 3 4 6
  • Acid Ceramidase-Like Protein 3 4
  • ASAH-Like Protein 3 4
  • PLT 3 4
  • N-Acylsphingosine Amidohydrolase (Acid Ceramidase)-Like 2
  • N-Acylethanolamine-Hydrolyzing Acid Amidase 3
  • N-Acylsphingosine Amidohydrolase-Like 4
  • EC 3.5.1.- 4

External Ids for NAAA Gene

Previous Symbols for NAAA Gene

  • ASAHL

Summaries for NAAA Gene

Entrez Gene Summary for NAAA Gene

  • This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAAA Gene

NAAA (N-Acylethanolamine Acid Amidase) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is ASAH1.

UniProtKB/Swiss-Prot for NAAA Gene

  • Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.

Gene Wiki entry for NAAA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAAA Gene

Genomics for NAAA Gene

Genomic Location for NAAA Gene

Start:
75,910,655 bp from pter
End:
75,941,051 bp from pter
Size:
30,397 bases
Orientation:
Minus strand

Genomic View for NAAA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAAA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAAA Gene

Regulatory Elements for NAAA Gene

Proteins for NAAA Gene

  • Protein details for NAAA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02083-NAAA_HUMAN
    Recommended name:
    N-acylethanolamine-hydrolyzing acid amidase
    Protein Accession:
    Q02083
    Secondary Accessions:
    • Q5KTF2
    • Q96EY2
    • Q9BRA8

    Protein attributes for NAAA Gene

    Size:
    359 amino acids
    Molecular mass:
    40066 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit, non-covalently linked.

    Alternative splice isoforms for NAAA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAAA Gene

Proteomics data for NAAA Gene at MOPED

Post-translational modifications for NAAA Gene

  • Autoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme.
  • N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.
  • Glycosylation at Asn37, Asn107, Asn309, and Asn333

Other Protein References for NAAA Gene

No data available for DME Specific Peptides for NAAA Gene

Domains for NAAA Gene

Protein Domains for NAAA Gene

UniProtKB/Swiss-Prot:

NAAA_HUMAN
Family:
  • Belongs to the acid ceramidase family.:
    • Q02083
genes like me logo Genes that share domains with NAAA: view

Function for NAAA Gene

Molecular function for NAAA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=97 uM for N-palmitoylethanolamine {ECO:0000269 PubMed:15655246}; pH dependence: Optimum pH is 4.5 with N-palmitoylethanolamine as substrate. {ECO:0000269 PubMed:15655246};
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by DTT and Nonidet P-40.
UniProtKB/Swiss-Prot Function: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.

Enzyme Numbers (IUBMB) for NAAA Gene

Gene Ontology (GO) - Molecular Function for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 21106534
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IDA 17980170
genes like me logo Genes that share ontologies with NAAA: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAAA Gene

Localization for NAAA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAAA Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAAA Gene COMPARTMENTS Subcellular localization image for NAAA gene
Compartment Confidence
lysosome 4
vacuole 4
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10610717
GO:0005764 lysosome IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NAAA: view

Pathways for NAAA Gene

SuperPathways for NAAA Gene

No Data Available

Interacting Proteins for NAAA Gene

Gene Ontology (GO) - Biological Process for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NAAA: view

No data available for Pathways by source for NAAA Gene

Compounds for NAAA Gene

(1) IUPHAR Ligand for NAAA Gene

Ligand Type Action Affinity Pubmed IDs
CCP Inhibitor Inhibition 5.3

(2) Novoseek inferred chemical compound relationships for NAAA Gene

Compound -log(P) Hits PubMed IDs
anandamide 79.1 2
monoacylglycerol 76.7 2
genes like me logo Genes that share compounds with NAAA: view

Transcripts for NAAA Gene

Unigene Clusters for NAAA Gene

N-acylethanolamine acid amidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAAA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for NAAA Gene

GeneLoc Exon Structure for
NAAA
ECgene alternative splicing isoforms for
NAAA

Expression for NAAA Gene

mRNA expression in normal human tissues for NAAA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAAA Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NAAA Gene

SOURCE GeneReport for Unigene cluster for NAAA Gene Hs.437365

mRNA Expression by UniProt/SwissProt for NAAA Gene

Q02083-NAAA_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
genes like me logo Genes that share expressions with NAAA: view

Orthologs for NAAA Gene

This gene was present in the common ancestor of animals.

Orthologs for NAAA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAAA 36
  • 97.3 (n)
  • 95.81 (a)
NAAA 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAAA 36
  • 84.37 (n)
  • 81.99 (a)
NAAA 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAAA 36
  • 87 (n)
  • 85.48 (a)
mouse
(Mus musculus)
Mammalia Naaa 36
  • 82.52 (n)
  • 79.27 (a)
Naaa 16
Naaa 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 48 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NAAA 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naaa 36
  • 81 (n)
  • 79.88 (a)
chicken
(Gallus gallus)
Aves NAAA 36
  • 69.33 (n)
  • 67.18 (a)
NAAA 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAAA 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9847 36
tropical clawed frog
(Silurana tropicalis)
Amphibia naaa 36
  • 64.08 (n)
  • 59.94 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55D5A.3 36
  • 46.88 (n)
  • 36.45 (a)
Y55D5A.3 37
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for NAAA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NAAA Gene

ENSEMBL:
Gene Tree for NAAA (if available)
TreeFam:
Gene Tree for NAAA (if available)

Paralogs for NAAA Gene

Paralogs for NAAA Gene

Selected SIMAP similar genes for NAAA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NAAA: view

Variants for NAAA Gene

Sequence variations from dbSNP and Humsavar for NAAA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs509812 -- 75,929,618(-) ACTAA(A/G)GTTTT intron-variant
rs657498 -- 75,929,774(-) CATAA(A/G)GCTTT intron-variant
rs905956 -- 75,925,523(-) TATAT(A/G)CTATT intron-variant
rs905958 -- 75,924,484(-) GTTAC(C/T)CACAG intron-variant
rs937788 -- 75,925,602(-) AGTGC(A/G)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAAA Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv822621 CNV Loss 20364138

Relevant External Links for NAAA Gene

HapMap Linkage Disequilibrium report
NAAA

Disorders for NAAA Gene

(2) University of Copenhagen DISEASES for NAAA Gene

Relevant External Links for NAAA

Genetic Association Database (GAD)
NAAA
Human Genome Epidemiology (HuGE) Navigator
NAAA
genes like me logo Genes that share disorders with NAAA: view

No data available for UniProtKB/Swiss-Prot for NAAA Gene

Publications for NAAA Gene

  1. Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein. (PMID: 10610717) Hong S.-B. … Schuchman E.H. (Genomics 1999) 2 3 4 23
  2. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. (PMID: 15655246) Tsuboi K. … Ueda N. (J. Biol. Chem. 2005) 3 4 23
  3. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PMID: 19014633) MA1ller T.D. … Hinney A. (Child Adolesc Psychiatry Ment Health 2008) 3 23 49
  4. A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta. (PMID: 1446826) Goodchild N.L. … Mager D.L. (Gene 1992) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NAAA Gene

Sources for NAAA Gene

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