Aliases for NAAA Gene
External Ids for NAAA Gene
Previous HGNC Symbols for NAAA Gene
Previous GeneCards Identifiers for NAAA Gene
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAAA Gene
NAAA (N-Acylethanolamine Acid Amidase) is a Protein Coding gene. Diseases associated with NAAA include marantic endocarditis and acquired thrombocytopenia. GO annotations related to this gene include transcription factor binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is ASAH1.
UniProtKB/Swiss-Prot for NAAA Gene
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.