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NAAA Gene

protein-coding   GIFtS: 54
GCID: GC04M076831

N-Acylethanolamine Acid Amidase

(Previous name: N-acylsphingosine amidohydrolase (acid ceramidase)-like)
(Previous symbol: ASAHL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acylethanolamine Acid Amidase1 2     N-Acylsphingosine Amidohydrolase (Acid Ceramidase)-Like1
ASAHL1 2 3 5     N-Acylethanolamine-Hydrolyzing Acid Amidase2
Acid Ceramidase-Like Protein2 3     EC 3.5.1.-3
PLT2 3     N-Acylsphingosine Amidohydrolase-Like3
ASAH-Like Protein2 3     

External Ids:    HGNC: 7361   Entrez Gene: 271632   Ensembl: ENSG000001387447   OMIM: 6074695   UniProtKB: Q020833   

Export aliases for NAAA gene to outside databases

Previous GC identifers: GC04M077050 GC04M072584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAAA Gene:
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAAA Gene:
NAAA (N-acylethanolamine acid amidase) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and transcription factor binding. An important paralog of this gene is ASAH1.

UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083
Function: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference:
N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine >
N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides
N-lauroylsphingosine and N-palmitoylsphingosine

Gene Wiki entry for NAAA (ASAHL) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAAA gene promoter:
         TBP   PPAR-gamma1   POU2F1   Sp1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAAA promoter sequence
   Search Chromatin IP Primers for NAAA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAAA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

NAAA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAAA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076831:  view genomic region     (about GC identifiers)

Start:
76,831,808 bp from pter      End:
76,862,204 bp from pter
Size:
30,397 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083 (See protein sequence)
Recommended Name: N-acylethanolamine-hydrolyzing acid amidase precursor  
Size: 359 amino acids; 40066 Da
Subunit: Heterodimer of an alpha and a beta subunit, non-covalently linked
Secondary accessions: Q5KTF2 Q96EY2 Q9BRA8
Alternative splicing: 3 isoforms:  Q02083-1   Q02083-2   Q02083-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NAAA: NX_Q02083

Explore proteomics data for NAAA at MOPED

Post-translational modifications: 

  • N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine1
  • Autoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme1
  • Glycosylation2 at Asn37, Asn107, Asn309, Asn333

  • See NAAA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035861.1  NP_055250.2  

    ENSEMBL proteins: 
     ENSP00000286733   ENSP00000423397   ENSP00000473575   ENSP00000427641   ENSP00000426977  
     ENSP00000423142   ENSP00000382420  

    NAAA Human Recombinant Protein Products:

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    antibodies-online proteins for NAAA (7 products) 

     
    antibodies-online peptides for NAAA

    NAAA Antibody Products:

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    antibodies-online antibodies for NAAA (24 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: N-Acylethanolamine acid amidase
    Endocannabinoid turnover

    2 InterPro protein domains:
     IPR003199 Chologlycine_hydro
     IPR016699 Acid_ceramidase-like

    Graphical View of Domain Structure for InterPro Entry Q02083

    ProtoNet protein and cluster: Q02083

    1 Blocks protein domain: IPB003199 Choloylglycine hydrolase

    UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083
    Similarity: Belongs to the acid ceramidase family


    Find genes that share domains with NAAA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAAA_HUMAN, Q02083
    Function: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference:
    N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine >
    N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides
    N-lauroylsphingosine and N-palmitoylsphingosine
    Enzyme regulation: Stimulated by DTT and Nonidet P-40
    Biophysicochemical properties: Kinetic parameters: KM=97 uM for N-palmitoylethanolamine; pH dependence: Optimum pH
    is 4.5 with N-palmitoylethanolamine as substrate;

         Enzyme Number (IUBMB): EC 3.5.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008134transcription factor binding IPI--
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IDA17980170
         
    Find genes that share ontologies with NAAA           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NAAA

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    2 qRT-PCR Assays for microRNAs that regulate NAAA:
    hsa-miR-136 hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidNAAA 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAAA_HUMAN, Q02083: Lysosome (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    vacuole4
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10610717
    GO:0005764lysosome IEA--

    Find genes that share ontologies with NAAA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAAA
    Interactions:

        GeneGlobe Interaction Network for NAAA

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with NAAA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAAA

    1 IUPHAR Ligand for NAAA (N-Acylethanolamine acid amidase)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCP
    InhibitorInhibition5.314686878

    2 Novoseek inferred chemical compound relationships for NAAA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anandamide 79.1 4 17980170 (1), 18793752 (1)
    monoacylglycerol 76.7 5 16375680 (1), 19014633 (1)



    Find genes that share compounds with NAAA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAAA gene (2 alternative transcripts): 
    NM_001042402.1  NM_014435.3  

    Unigene Cluster for NAAA:

    N-acylethanolamine acid amidase
    Hs.437365  [show with all ESTs]
    Unigene Representative Sequence: NM_014435
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286733(uc003hjb.3) ENST00000511606 ENST00000513045 ENST00000602782
    ENST00000507956(uc003hjc.4 uc003hjd.4) ENST00000505594(uc011cbq.2)
    ENST00000507187(uc010iiz.1) ENST00000507940 ENST00000503636 ENST00000399497(uc003hja.3)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate NAAA:
    hsa-miR-136 hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidNAAA 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB161353.1 AK024677.1 AK301132.1 AK309271.1 M92449.1 

    15 DOTS entries:

    DT.86857920  DT.109510  DT.91959761  DT.211615  DT.91816216  DT.40111879  DT.121268169  DT.92426440 
    DT.95229006  DT.121268102  DT.95182109  DT.95288709  DT.95288708  DT.97840369  DT.99944948 

    Selected AceView cDNA sequences (see all 140):

    BQ189557 CK300406 AW614594 BE503233 AA974051 BQ051465 AI685903 BM725506 
    BM719630 BM682907 AA995567 W47576 AI348673 R09660 BM682921 AA426330 
    AI701976 AI241573 CA942081 BM847445 AI088304 AI056658 AI580701 BM678138 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAAA (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:        -           -                                                                                       
    SP2:        -           -                                                     -                                 
    SP3:        -           -                 -                                   -                                 
    SP4:                                                                          -     -                           
    SP5:                                                                                -                           


    ECgene alternative splicing isoforms for NAAA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAAA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGGGAGT
    NAAA Expression
    About this image


    NAAA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
    NAAA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAAA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437365

    UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083
    Tissue specificity: Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NAAA gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naaa1 , 5 N-acylethanolamine acid amidase1, 5 82.52(n)1
    79.27(a)1
      5 (46.35 cM)5
    671111  NM_025972.41  NP_080248.21 
     922576595 
    chicken
    (Gallus gallus)
    Aves NAAA1 N-acylethanolamine acid amidase 69.33(n)
    67.18(a)
      422641  XM_420596.4  XP_420596.2 
    lizard
    (Anolis carolinensis)
    Reptilia NAAA6
    N-acylethanolamine acid amidase
    66(a)
    1 ↔ 1
    5(146979611-146993285)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98472 Xenopus laevis transcribed sequence with weak similarity more 80.16(n)    CD329942.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y55D5A.31 Y55D5A.3 46.88(n)
    36.45(a)
      190304  NM_065246.1  NP_497647.1 


    ENSEMBL Gene Tree for NAAA (if available)
    TreeFam Gene Tree for NAAA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAAA gene
    ASAH12  
    1 SIMAP similar gene for NAAA using alignment to 5 protein entries:     NAAA_HUMAN (see all proteins):
    ASAH1

    Find genes that share paralogs with NAAA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAAA (see all 819)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400027341,2
    --76683132(+) TTCTAC/GCAAGA 2 -- us2k10--------
    rs560094881,2
    C,F--76831349(+) ACCACG/ACCCAG 1 -- ds50012Minor allele frequency- A:0.06CSA NA 121
    rs557017421,2
    C,F--76831365(+) AACAAC/AATTTT 1 -- ds50012Minor allele frequency- A:0.26CSA WA 119
    rs1908468591,2
    --76831477(+) ACTGTA/GCCTGT 1 -- ds50010--------
    rs1493833561,2
    C--76831479(+) TGTGC-/CTGT  
            
    CTGTC
    1 -- ds50010--------
    rs1124916571,2
    F--76831518(+) CCACTG/TTGTGT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs559879761,2
    C,F--76831563(+) ATGGAC/TATTTA 1 -- ds50013Minor allele frequency- T:0.15CSA WA NA 239
    rs1839215501,2
    --76831678(+) AATTTC/GTTTTC 1 -- ds50010--------
    rs790640191,2
    C--76831687(+) TCCCTG/TCTGGT 1 -- ds50013Minor allele frequency- T:0.16CSA WA NA 239
    rs1167445171,2
    --76831688(+) CCCTGC/TTGGTT 1 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for NAAA (76831808 - 76862204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NAAA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822621CNV Loss20364138
    nsv7363OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607469    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for NAAA:
    Thrombocytopenia     Anemia

    Find genes that share disorders with NAAA           About GenesLikeMe

    Genetic Association Database (GAD): NAAA
    Human Genome Epidemiology (HuGE) Navigator: NAAA (1 document)

    Export disorders for NAAA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAAA gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NAAA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein. (PubMed id 10610717)1, 2, 3, 9 Hong S.-B.... Schuchman E.H. (Genomics 1999)
    2. A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta. (PubMed id 1446826)1, 2, 3 Goodchild N.L.... Mager D.L. (Gene 1992)
    3. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. (PubMed id 15655246)1, 2, 9 Tsuboi K.... Ueda N. (J. Biol. Chem. 2005)
    4. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PubMed id 19014633)1, 4, 9 MA1ller T.D....Hinney A. (Child Adolesc Psychiatry Ment Health 2008)
    5. Mass spectrometric characterization of human N-acylethanolamine- hydrolyzing acid amidase. (PubMed id 22040171)1, 2 West J.M.... Makriyannis A. (J. Proteome Res. 2012)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. (PubMed id 17980170)1, 9 Zhao L.Y....Ueda N. (Biochim. Biophys. Acta 2007)
    8. Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. (PubMed id 18806270)1, 9 Wang J....Ueda N. (J. Biochem. 2008)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27163 HGNC: 736 AceView: ASAHL Ensembl:ENSG00000138744 euGenes: HUgn27163
    ECgene: NAAA H-InvDB: NAAA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAAA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAAA gene:
    Search GeneIP for patents involving NAAA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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