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Aliases for NAAA Gene

Aliases for NAAA Gene

  • N-Acylethanolamine Acid Amidase 2 3 5
  • Acid Ceramidase-Like Protein 3 4
  • ASAH-Like Protein 3 4
  • ASAHL 3 4
  • PLT 3 4
  • N-Acylsphingosine Amidohydrolase (Acid Ceramidase)-Like 2
  • N-Acylethanolamine-Hydrolyzing Acid Amidase 3
  • N-Acylsphingosine Amidohydrolase-Like 4
  • EC 3.5.1.- 4

External Ids for NAAA Gene

Previous HGNC Symbols for NAAA Gene

  • ASAHL

Previous GeneCards Identifiers for NAAA Gene

  • GC04M077050
  • GC04M076831
  • GC04M072584

Summaries for NAAA Gene

Entrez Gene Summary for NAAA Gene

  • This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAAA Gene

NAAA (N-Acylethanolamine Acid Amidase) is a Protein Coding gene. Diseases associated with NAAA include Acquired Thrombocytopenia and Marantic Endocarditis. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. GO annotations related to this gene include transcription factor binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is ASAH1.

UniProtKB/Swiss-Prot for NAAA Gene

  • Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.

Gene Wiki entry for NAAA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAAA Gene

Genomics for NAAA Gene

Regulatory Elements for NAAA Gene

Enhancers for NAAA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F075984 0.5 ENCODE 66.2 -44.4 -44360 1.8 FOS MAFK NFE2L2 NAAA ART3 LOC101928809 SDAD1
GH04F075939 0.6 ENCODE 64.3 +0.5 544 2.1 TBP HDAC1 ATF1 PKNOX1 SIN3A DMAP1 ZNF48 RAD21 KLF7 CREM NAAA PPEF2 SCARB2 ART3 GC04M075942 PIR50646
GH04F075901 0.9 FANTOM5 Ensembl ENCODE 30.9 +39.1 39086 1.3 SMARCE1 MAFG CEBPB EBF1 NR2F2 ZNF664 ZNF316 MAFK EMSY SPI1 NAAA CXCL10 CXCL9 CXCL11 THAP6 RCHY1 PPEF2 LOC105377285
GH04F076059 1.7 FANTOM5 Ensembl ENCODE 26.8 -119.1 -119145 1.6 ATF1 NR2F1 ZNF175 ZNF384 ZBTB40 ZGPAT ZNF512 IKZF1 CREB1 SPI1 ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 LOC101928809 GC04P076101
GH04F076055 1.4 Ensembl ENCODE 26 -114.2 -114150 0.4 PKNOX1 MTA2 JUNB TRIM22 BMI1 TBX21 RELA JUND CBX5 TARDBP NAAA CXCL10 CXCL9 SDAD1 ART3 CXCL11 GC04P076101
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAAA on UCSC Golden Path with GeneCards custom track

Promoters for NAAA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001243212 551 1801 TBP HDAC1 ATF1 PKNOX1 SIN3A DMAP1 ZNF48 RAD21 KLF7 CREM

Genomic Location for NAAA Gene

Chromosome:
4
Start:
75,910,655 bp from pter
End:
75,941,051 bp from pter
Size:
30,397 bases
Orientation:
Minus strand

Genomic View for NAAA Gene

Genes around NAAA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAAA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAAA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAAA Gene

Proteins for NAAA Gene

  • Protein details for NAAA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02083-NAAA_HUMAN
    Recommended name:
    N-acylethanolamine-hydrolyzing acid amidase
    Protein Accession:
    Q02083
    Secondary Accessions:
    • Q5KTF2
    • Q96EY2
    • Q9BRA8

    Protein attributes for NAAA Gene

    Size:
    359 amino acids
    Molecular mass:
    40066 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit, non-covalently linked.

    Alternative splice isoforms for NAAA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAAA Gene

Post-translational modifications for NAAA Gene

  • Autoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme.
  • N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.
  • Glycosylation at Asn 37, Asn 107, Asn 309, and Asn 333

Antibody Products

  • R&D Systems Antibodies for NAAA (ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NAAA

No data available for DME Specific Peptides for NAAA Gene

Domains & Families for NAAA Gene

Gene Families for NAAA Gene

Protein Domains for NAAA Gene

Graphical View of Domain Structure for InterPro Entry

Q02083

UniProtKB/Swiss-Prot:

NAAA_HUMAN :
  • Belongs to the acid ceramidase family.
Family:
  • Belongs to the acid ceramidase family.
genes like me logo Genes that share domains with NAAA: view

Function for NAAA Gene

Molecular function for NAAA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=97 uM for N-palmitoylethanolamine {ECO:0000269 PubMed:15655246}; pH dependence: Optimum pH is 4.5 with N-palmitoylethanolamine as substrate. {ECO:0000269 PubMed:15655246};
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by DTT and Nonidet P-40.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.

Enzyme Numbers (IUBMB) for NAAA Gene

Gene Ontology (GO) - Molecular Function for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 21106534
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds TAS --
genes like me logo Genes that share ontologies with NAAA: view
genes like me logo Genes that share phenotypes with NAAA: view

Animal Models for NAAA Gene

MGI Knock Outs for NAAA:
  • Naaa tm1a(KOMP)Wtsi

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAAA Gene

Localization for NAAA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAAA Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAAA Gene COMPARTMENTS Subcellular localization image for NAAA gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
cytosol 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10610717
GO:0005764 lysosome IEA --
GO:0043202 lysosomal lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with NAAA: view

Pathways & Interactions for NAAA Gene

genes like me logo Genes that share pathways with NAAA: view

Pathways by source for NAAA Gene

Interacting Proteins for NAAA Gene

Selected Interacting proteins: Q02083-NAAA_HUMAN for NAAA Gene via IID

Gene Ontology (GO) - Biological Process for NAAA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007269 neurotransmitter secretion TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NAAA: view

No data available for SIGNOR curated interactions for NAAA Gene

Drugs & Compounds for NAAA Gene

(2) Drugs for NAAA Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCP Pharma Inhibition, Inhibitor 0

(1) Additional Compounds for NAAA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAAA: view

Transcripts for NAAA Gene

Unigene Clusters for NAAA Gene

N-acylethanolamine acid amidase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAAA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for NAAA Gene

GeneLoc Exon Structure for
NAAA
ECgene alternative splicing isoforms for
NAAA

Expression for NAAA Gene

mRNA expression in normal human tissues for NAAA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAAA Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for NAAA Gene

This gene is overexpressed in Spleen (18.2) and Tlymphocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAAA Gene



Protein tissue co-expression partners for NAAA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAAA Gene:

NAAA

SOURCE GeneReport for Unigene cluster for NAAA Gene:

Hs.437365

mRNA Expression by UniProt/SwissProt for NAAA Gene:

Q02083-NAAA_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
genes like me logo Genes that share expression patterns with NAAA: view

Primer Products

Orthologs for NAAA Gene

This gene was present in the common ancestor of animals.

Orthologs for NAAA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAAA 34 35
  • 97.3 (n)
dog
(Canis familiaris)
Mammalia NAAA 34
  • 87 (n)
cow
(Bos Taurus)
Mammalia NAAA 34 35
  • 84.37 (n)
mouse
(Mus musculus)
Mammalia Naaa 34 16 35
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Naaa 34
  • 81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAAA 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves NAAA 34 35
  • 69.33 (n)
lizard
(Anolis carolinensis)
Reptilia NAAA 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naaa 34
  • 64.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9847 34
worm
(Caenorhabditis elegans)
Secernentea Y55D5A.3 34 35
  • 46.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for NAAA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NAAA Gene

ENSEMBL:
Gene Tree for NAAA (if available)
TreeFam:
Gene Tree for NAAA (if available)

Paralogs for NAAA Gene

Paralogs for NAAA Gene

(1) SIMAP similar genes for NAAA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NAAA: view

Variants for NAAA Gene

Sequence variations from dbSNP and Humsavar for NAAA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10017825 -- 75,926,493(+) gaggc(A/G)gaggt intron-variant
rs10023375 -- 75,916,064(+) TTGCT(C/T)GTTTA intron-variant, downstream-variant-500B
rs10026390 -- 75,916,936(+) catga(C/T)gcctg intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10155195 -- 75,919,602(+) GCCTC(C/T)GGAGT intron-variant
rs1050460 -- 75,914,215(-) TGCGA(A/G)GTGGG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAAA Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855
nsv822621 CNV loss 20364138

Variation tolerance for NAAA Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAAA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAAA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAAA Gene

Disorders for NAAA Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAAA Gene - From: DISEASES

Disorder Aliases PubMed IDs
acquired thrombocytopenia
  • secondary thrombocytopenia
marantic endocarditis
  • non-bacterial thrombotic endocarditis
- elite association - COSMIC cancer census association via MalaCards
Search NAAA in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAAA

Genetic Association Database (GAD)
NAAA
Human Genome Epidemiology (HuGE) Navigator
NAAA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAAA
genes like me logo Genes that share disorders with NAAA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAAA Gene

Publications for NAAA Gene

  1. Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein. (PMID: 10610717) Hong S.-B. … Schuchman E.H. (Genomics 1999) 2 3 4 22 64
  2. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PMID: 19014633) MA1ller T.D. … Hinney A. (Child Adolesc Psychiatry Ment Health 2008) 3 22 46 64
  3. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. (PMID: 15655246) Tsuboi K. … Ueda N. (J. Biol. Chem. 2005) 3 4 22 64
  4. A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta. (PMID: 1446826) Goodchild N.L. … Mager D.L. (Gene 1992) 2 3 4 64
  5. Mass spectrometric characterization of human N-acylethanolamine- hydrolyzing acid amidase. (PMID: 22040171) West J.M. … Makriyannis A. (J. Proteome Res. 2012) 3 4 64

Products for NAAA Gene

Sources for NAAA Gene

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