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Aliases for NAA60 Gene

Aliases for NAA60 Gene

  • N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit 2 3
  • NAT15 3 4 6
  • N-Acetyltransferase 15 (GCN5-Related, Putative) 2 3
  • Histone Acetyltransferase Type B Protein 4 3 4
  • NatF Catalytic Subunit 3 4
  • HAT4 3 4
  • N-Alpha-Acetyltransferase 60 3
  • N-Acetyltransferase 15 4
  • EC 2.3.1.48 4
  • EC 2.3.1.88 4

External Ids for NAA60 Gene

Previous HGNC Symbols for NAA60 Gene

  • NAT15

Previous GeneCards Identifiers for NAA60 Gene

  • GC16P003495

Summaries for NAA60 Gene

GeneCards Summary for NAA60 Gene

NAA60 (N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include peptide alpha-N-acetyltransferase activity and H4 histone acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA60 Gene

  • Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 Lys-20(H4K20ac), Lys-79(H4K79ac) and Lys-91 (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA60 Gene

Genomics for NAA60 Gene

Genomic Location for NAA60 Gene

Start:
3,443,611 bp from pter
End:
3,486,963 bp from pter
Size:
43,353 bases
Orientation:
Plus strand

Genomic View for NAA60 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA60 Gene

No data available for Regulatory Elements for NAA60 Gene

Proteins for NAA60 Gene

  • Protein details for NAA60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X0-NAA60_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 60
    Protein Accession:
    Q9H7X0
    Secondary Accessions:
    • B3KRQ0
    • B4DLZ0
    • B4DPZ8
    • B4DYC4
    • D3DUC2
    • E7EQ65
    • Q6IA31
    • Q6UX26

    Protein attributes for NAA60 Gene

    Size:
    242 amino acids
    Molecular mass:
    27451 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAA60 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA60 Gene

Proteomics data for NAA60 Gene at MOPED

Post-translational modifications for NAA60 Gene

  • Acetylated: autoacetylation is required for optimal acetyltransferase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA60 Gene

Domains for NAA60 Gene

Gene Families for NAA60 Gene

HGNC:
  • NAA :N(alpha)-acetyltransferase subunits

Protein Domains for NAA60 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7X0

UniProtKB/Swiss-Prot:

NAA60_HUMAN :
  • Q9H7X0
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. NAA60 subfamily.
genes like me logo Genes that share domains with NAA60: view

No data available for Suggested Antigen Peptide Sequences for NAA60 Gene

Function for NAA60 Gene

Molecular function for NAA60 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function: Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 Lys-20(H4K20ac), Lys-79(H4K79ac) and Lys-91 (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.
UniProtKB/Swiss-Prot Induction: Isoform 2 is imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in placenta and leukocytes. Isoform 1 is biallelically expressed.

Enzyme Numbers (IUBMB) for NAA60 Gene

Gene Ontology (GO) - Molecular Function for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 21750686
GO:0008080 N-acetyltransferase activity --
GO:0010485 H4 histone acetyltransferase activity IDA 21981917
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with NAA60: view

miRNA for NAA60 Gene

miRTarBase miRNAs that target NAA60

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAA60 Gene

Localization for NAA60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA60 Gene

Golgi apparatus membrane.

Gene Ontology (GO) - Cellular Components for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 21981917
genes like me logo Genes that share ontologies with NAA60: view

No data available for Subcellular locations from COMPARTMENTS for NAA60 Gene

Pathways for NAA60 Gene

SuperPathways for NAA60 Gene

No Data Available

Interacting Proteins for NAA60 Gene

Gene Ontology (GO) - Biological Process for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IDA 21981917
GO:0007059 chromosome segregation ISS --
GO:0008152 metabolic process --
GO:0008283 cell proliferation IMP 21981917
GO:0017196 N-terminal peptidyl-methionine acetylation IDA 21750686
genes like me logo Genes that share ontologies with NAA60: view

No data available for Pathways by source for NAA60 Gene

Transcripts for NAA60 Gene

Unigene Clusters for NAA60 Gene

N(alpha)-acetyltransferase 60, NatF catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA60 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -

Relevant External Links for NAA60 Gene

GeneLoc Exon Structure for
NAA60
ECgene alternative splicing isoforms for
NAA60

Expression for NAA60 Gene

mRNA expression in normal human tissues for NAA60 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NAA60 Gene

SOURCE GeneReport for Unigene cluster for NAA60 Gene Hs.513296

genes like me logo Genes that share expressions with NAA60: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA60 Gene

Orthologs for NAA60 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NAA60 35
  • 90.36 (n)
  • 95.87 (a)
NAA60 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
NAA60 35
  • 91.87 (n)
  • 97.11 (a)
mouse
(Mus musculus)
Mammalia Naa60 35
  • 93.25 (n)
  • 97.11 (a)
Naa60 16
Naa60 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Naa60 35
  • 92.84 (n)
  • 97.52 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 81 (a)
OneToMany
NAA60 35
  • 83.88 (n)
  • 90.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naa60 35
  • 75.21 (n)
  • 80.99 (a)
zebrafish
(Danio rerio)
Actinopterygii nat15 35
  • 80.03 (n)
  • 88.84 (a)
nat15 36
  • 89 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005192 35
  • 57.75 (n)
  • 57.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Naa60 35
  • 55.95 (n)
  • 55.78 (a)
Naa60 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30F8.10 35
  • 46.67 (n)
  • 41.08 (a)
F30F8.10 36
  • 31 (a)
OneToMany
Species with no ortholog for NAA60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA60 Gene

ENSEMBL:
Gene Tree for NAA60 (if available)
TreeFam:
Gene Tree for NAA60 (if available)

Paralogs for NAA60 Gene

No data available for Paralogs for NAA60 Gene

Variants for NAA60 Gene

Sequence variations from dbSNP and Humsavar for NAA60 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs28401 -- 3,465,354(-) GACCA(C/G)AAGAT intron-variant
rs28810 -- 3,450,515(+) ctaac(A/G)tggtg intron-variant
rs37766 -- 3,465,279(-) ctttt(C/T)ttttt intron-variant
rs37767 -- 3,464,962(+) TCACC(C/T)CAATT intron-variant
rs37768 -- 3,464,777(+) TGAGT(C/T)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA60 Gene

Variant ID Type Subtype PubMed ID
esv29492 CNV Gain 19812545
nsv512420 CNV Loss 21212237
nsv1715 CNV Loss 18451855
nsv905213 CNV Loss 21882294
dgv361e201 CNV Deletion 23290073
dgv362e201 CNV Deletion 23290073
esv2750408 CNV Deletion 23290073
esv2665923 CNV Deletion 23128226
esv2750409 CNV Deletion 23290073
nsv905214 CNV Loss 21882294
nsv905215 CNV Loss 21882294

Relevant External Links for NAA60 Gene

HapMap Linkage Disequilibrium report
NAA60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA60 Gene

Disorders for NAA60 Gene

No disorders were found for NAA60 Gene.

No data available for UniProtKB/Swiss-Prot for NAA60 Gene

Publications for NAA60 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. (PMID: 21750686) Van Damme P. … Arnesen T. (PLoS Genet. 2011) 2 3 4
  3. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. (PMID: 21981917) Yang X. … Shang Y. (Mol. Cell 2011) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for NAA60 Gene

Sources for NAA60 Gene

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