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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NAA60 Gene

protein-coding GIFtS: 39
GCID: GC16P003495

N(alpha)-acetyltransferase 60, NatF catalytic subunit

(Previous names: N-acetyltransferase 15 (GCN5-related, putative) )
(Previous symbol: NAT15)

Search for NAA60
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit¹ ²		FLJ14154¹
NAT15¹ ² ³		N-Alpha-Acetyltransferase 60²
N-Acetyltransferase 15 (GCN5-Related, Putative)¹ ²		EC 2.3.1.48³
Histone Acetyltransferase Type B Protein 4² ³		EC 2.3.1.88³
NatF Catalytic Subunit² ³		N-Acetyltransferase 15³
HAT4² ³

External Ids:	HGNC: 25875¹	Entrez Gene: 79903²	Ensembl: ENSG00000122390⁷	OMIM: 614246⁵	UniProtKB: Q9H7X0³

Export aliases for NAA60 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NAA60_HUMAN, Q9H7X0

Function: Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4,

thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac)

and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal

sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal

segregation during anaphase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for NAA60
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAA60 promoter sequence

Search SABiosciences Chromatin IP Primers for NAA60

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA60

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

NAA60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAA60 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P003495: view genomic region (about GC identifiers)

Start:	3,493,611 bp from pter	End:	3,536,963 bp from pter
Size:	43,353 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NAA60_HUMAN, Q9H7X0 (See protein sequence)

Recommended Name: N-alpha-acetyltransferase 60

Size: 242 amino acids; 27451 Da

Subcellular location: Golgi apparatus membrane

Secondary accessions: B3KRQ0 B4DLZ0 B4DPZ8 B4DYC4 D3DUC2 E7EQ65 Q6IA31 Q6UX26

Alternative promoter usage, Alternative splicing: 5 isoforms: Q9H7X0-1 Q9H7X0-2 Q9H7X0-3 Q9H7X0-4 Q9H7X0-5 (Produced by alternative splicing. Ref.2 (BAG60760) sequence is in conflict in position: 180:R->Q. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NAA60: NX_Q9H7X0

Post-translational modifications:

Acetylated: autoacetylation is required for optimal acetyltransferase activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H7X0

NAA60 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001077069.1 NP_001077070.1 NP_079121.1

ENSEMBL proteins:

ENSP00000385903 ENSP00000458928 ENSP00000459750 ENSP00000459084 ENSP00000461507

ENSP00000401237 ENSP00000461443 ENSP00000458505 ENSP00000459275 ENSP00000459055

ENSP00000459544 ENSP00000405873 ENSP00000354108 ENSP00000393224 ENSP00000461438

ENSP00000459188 ENSP00000458717 ENSP00000461730 ENSP00000461703 ENSP00000458667

ENSP00000459790 ENSP00000458575 ENSP00000460763 ENSP00000459057

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	Uscn Proteins for NAA60

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IDA	--
GO:0005575	cellular_component	ND	--

NAA60 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NAA60 for domains About GeneDecksing

2 InterPro domains/families:

IPR000182 GNAT_dom

IPR016181 Acyl_CoA_acyltransferase

Graphical View of Domain Structure for InterPro Entry Q9H7X0

ProtoNet protein and cluster: Q9H7X0

1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase

UniProtKB/Swiss-Prot: NAA60_HUMAN, Q9H7X0

Similarity: Belongs to the acetyltransferase family. NAA60 subfamily

Similarity: Contains 1 N-acetyltransferase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NAA60_HUMAN, Q9H7X0

Function: Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4,

thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac)

and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal

sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal

segregation during anaphase

Catalytic activity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

Induction: Isoform 2 is imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal

allele in placenta and leukocytes. Isoform 1 is biallelically expressed

Enzyme Numbers (IUBMB): EC 2.3.1.88¹ EC 2.3.1.48¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004596	peptide alpha-N-acetyltransferase activity	IDA	--
GO:0008080	N-acetyltransferase activity	--	--
GO:0010485	H4 histone acetyltransferase activity	IDA	--

NAA60 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NAA60

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA60

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NAA60

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IDA	--
GO:0007059	chromosome segregation	ISS	--
GO:0008283	cell proliferation	IMP	--
GO:0017196	N-terminal peptidyl-methionine acetylation	IDA	--
GO:0043967	histone H4 acetylation	IDA	--

NAA60 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NAA60
Search CenterWatch for drugs/clinical trials and news about NAA60

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NAA60 gene (3 alternative transcripts):

NM_001083600.1 NM_001083601.1 NM_024845.2

Unigene Cluster for NAA60:

N(alpha)-acetyltransferase 60, NatF catalytic subunit

Hs.513296 [show with all ESTs]

Unigene Representative Sequence: CR749599

18/37 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 37):

ENST00000407558(uc002cvh.4) ENST00000572169 ENST00000572757 ENST00000573593

ENST00000573617 ENST00000570372 ENST00000575936 ENST00000424546(uc010uxb.1)

ENST00000575733 ENST00000573201 ENST00000574950 ENST00000573580 ENST00000575042

ENST00000574256 ENST00000574762 ENST00000574328 ENST00000421765 ENST00000360862(uc010btk.1)

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Additional cDNA sequence:

AK021755.1 AK024216.1 AK092005.1 AK095819.1 AK130792.1 AK225178.1 AK297219.1 AK298566.1

AK302361.1 AK311524.1 AL833594.1 AY358543.1 BC011267.1 CR457324.1 CR749599.1

24/44 DOTS entries (see all 44):

DT.120703715 DT.100829477 DT.86859797 DT.100816029 DT.120703678 DT.120703654 DT.100816024 DT.91916319

DT.91651059 DT.120703671 DT.100699073 DT.120703749 DT.120703783 DT.40317216 DT.100816033 DT.120703753

DT.100031698 DT.100816030 DT.120703724 DT.120703725 DT.92415503 DT.95153981 DT.120703682 DT.120703705

24/318 AceView cDNA sequences (see all 318):

BP349992 AI807288 AU122697 BP364197 AU280121 BQ643197 AA877539 AW511751

BM982082 AI470314 BQ061773 BE220079 BG385807 BQ068723 BM832977 BP356474

CD106389 CR614322 AW473326 BP376716 BF206237 BX401428 BM854898 AI870372

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NAA60 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4	^	5	^	6a	·	6b
SP1:					-		-		-		-		-
SP2:					-		-		-		-		-		-		-
SP3:
SP4:
SP5:													-

ECgene alternative splicing isoforms for NAA60

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NAA60 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATTTGTC

About this image
See NAA60 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAA60

SOURCE GeneReport for Unigene cluster: Hs.513296
SABiosciences Custom PCR Arrays for NAA60

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA60 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Naa60⁵ Nat15¹	N-acetyltransferase 15 (GCN5-related, putative)^{1, 5}	93.25(n)¹ 97.11(a)¹		16 (2.28 cM)⁵ 74763¹ NM_029090.3¹ NP_083366.1¹ 3872375⁵
chicken (Gallus gallus)	Aves	NAT15¹	N-acetyltransferase 15 (GCN5-related, putative)	83.88(n) 90.91(a)		416659 XM_414956.3 XP_414956.1
lizard (Anolis carolinensis)	Reptilia	NAA60⁶	--	89(a)	1 ↔ 1	GL343691.1(40214-41863)
zebrafish (Danio rerio)	Actinopterygii	nat15¹	N-acetyltransferase 15 (GCN5-related, putative)	80.03(n) 88.84(a)		570640 NM_001082872.1 NP_001076341.1
fruit fly (Drosophila melanogaster)	Insecta	Naa60¹	N(alpha)-acetyltransferase 60	54.53(n) 55.34(a)		39142 NM_001144457.2 NP_001137929.1
worm (Caenorhabditis elegans)	Secernentea	F30F8.10¹	Protein F30F8.10	45.47(n) 38.46(a)		3565178 NM_001128995.1 NP_001122467.1
thale cress (Arabidopsis thaliana)	eudicotyledons	MCC1⁶ AT5G16800⁶	meiotic control of crossovers1 protein GCN5-related N-acetyltransferase (GNAT) family pro...	22(a) 19(a)	many → 1 many → 1	3(670897-672215) 5(5524282-5526589)
rice (Oryza sativa)	Liliopsida	--	GCN5-related N-acetyltransferase, putative, expres...	22(a)	1 ↔ 1	2(28511246-28515147)

ENSEMBL Gene Tree for NAA60 (if available)
TreeFam Gene Tree for NAA60 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs37832^1,2	C,F,A	--	3461580(+)	`caggaG/Cgcaga`	1	--	int¹		5		NA WA CSA	10
rs202220422^1,2	C	--	3461671(-)	`CTTTTC/TTTTTC`	1	--	int¹		0	--	--	--	--
rs8048531^1,2	A	--	3462202(+)	`ttagcA/Cgggcg`	1	--	int¹		0	--	--	--	--
rs8044544^1,2	C	--	3462286(+)	`gcttgC/Tagtga`	1	--	int¹		0	--	--	--	--
rs3816916^1,2	C,F,H	--	3462910(+)	`GGACCA/CATTCC`	1	--	int¹		25		EA NA NS WA CSA	2428
rs34496784^1,2	C,F	--	3462958(+)	`TTCCCT/CCCGAA`	1	--	int¹		6		WA CSA NA EA	364
rs7500590^1,2	C,F	--	3462971(+)	`CCCCCT/CTAAAA`	1	--	int¹		5		WA NA EA	362
rs59220957^1,2	C,F	--	3463003(+)	`TCTTGG/TCCCGG`	1	--	int¹		3		WA CSA	122
rs13330347^1,2	C	--	3463199(+)	`CAGCCC/TTCTCC`	1	--	us2k¹		2		WA	120
rs12923869^1,2	C,F,H	--	3463400(+)	`GCCTGC/TTGAAG`	1	--	us2k¹		7		NS EA NA	422

HapMap Linkage Disequilibrium report for NAA60 (3493611 - 3536963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAA60: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NAA60 for disorders About MalaCards

NAA60 for disorders About GeneDecksing

OMIM gene information: 614246 OMIM disorders: --

Export disorders for NAA60 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NAA60 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NAA60)

Utopia: connect your pdf to the dynamic
world of online information

NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. (PubMed id 21750686)^{1, 2, 3} Van Damme P....Arnesen T. (2011)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. (PubMed id 21981917)^{1, 2} Yang X.... Shang Y. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PubMed id 21593219)² Nakabayashi K.... Monk D. (2011)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79903	HGNC: 25875	AceView: FLJ14154	Ensembl:ENSG00000122390	euGenes: HUgn79903
ECgene: NAA60	H-InvDB: NAA60

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NAA60	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NAA60 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NAA60 gene:
Search GeneIP for patents involving NAA60

GeneCards and IP:
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NAA60 Gene

N(alpha)-acetyltransferase 60, NatF catalytic subunit

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NAA60 Gene

N(alpha)-acetyltransferase 60, NatF catalytic subunit

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