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Aliases for NAA60 Gene

Aliases for NAA60 Gene

  • N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit 2 3 5
  • N-Acetyltransferase 15 (GCN5-Related, Putative) 2 3
  • Histone Acetyltransferase Type B Protein 4 3 4
  • NAT15 3 4
  • HAT4 3 4
  • N-Acetyltransferase 15 4
  • NatF Catalytic Subunit 4
  • EC 2.3.1.48 4
  • EC 2.3.1.88 4

External Ids for NAA60 Gene

Previous HGNC Symbols for NAA60 Gene

  • NAT15

Previous GeneCards Identifiers for NAA60 Gene

  • GC16P003495

Summaries for NAA60 Gene

Entrez Gene Summary for NAA60 Gene

  • This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

GeneCards Summary for NAA60 Gene

NAA60 (N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA60 Gene

  • Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 Lys-20(H4K20ac), Lys-79(H4K79ac) and Lys-91 (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA60 Gene

Genomics for NAA60 Gene

Regulatory Elements for NAA60 Gene

Enhancers for NAA60 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAA60 on UCSC Golden Path with GeneCards custom track

Promoters for NAA60 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAA60 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA60 Gene

Chromosome:
16
Start:
3,443,611 bp from pter
End:
3,486,963 bp from pter
Size:
43,353 bases
Orientation:
Plus strand

Genomic View for NAA60 Gene

Genes around NAA60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA60 Gene

Proteins for NAA60 Gene

  • Protein details for NAA60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X0-NAA60_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 60
    Protein Accession:
    Q9H7X0
    Secondary Accessions:
    • B3KRQ0
    • B4DLZ0
    • B4DPZ8
    • B4DYC4
    • D3DUC2
    • E7EQ65
    • Q6IA31
    • Q6UX26

    Protein attributes for NAA60 Gene

    Size:
    242 amino acids
    Molecular mass:
    27451 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAA60 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA60 Gene

Proteomics data for NAA60 Gene at MOPED

Post-translational modifications for NAA60 Gene

  • Acetylated: autoacetylation is required for optimal acetyltransferase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA60 Gene

Domains & Families for NAA60 Gene

Protein Domains for NAA60 Gene

Suggested Antigen Peptide Sequences for NAA60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7X0

UniProtKB/Swiss-Prot:

NAA60_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. NAA60 subfamily.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. NAA60 subfamily.
genes like me logo Genes that share domains with NAA60: view

Function for NAA60 Gene

Molecular function for NAA60 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 Lys-20(H4K20ac), Lys-79(H4K79ac) and Lys-91 (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.
UniProtKB/Swiss-Prot Induction:
Isoform 2 is imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in placenta and leukocytes. Isoform 1 is biallelically expressed.

Enzyme Numbers (IUBMB) for NAA60 Gene

Gene Ontology (GO) - Molecular Function for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with NAA60: view
genes like me logo Genes that share phenotypes with NAA60: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA60

CRISPR Products

miRNA for NAA60 Gene

miRTarBase miRNAs that target NAA60

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA60 Gene

Localization for NAA60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA60 Gene

Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA60 Gene COMPARTMENTS Subcellular localization image for NAA60 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for NAA60 Gene

Pathways & Interactions for NAA60 Gene

SuperPathways for NAA60 Gene

No Data Available

Interacting Proteins for NAA60 Gene

Gene Ontology (GO) - Biological Process for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IDA 21981917
GO:0007059 chromosome segregation ISS --
GO:0008152 metabolic process IEA --
GO:0043967 histone H4 acetylation IDA 21981917
genes like me logo Genes that share ontologies with NAA60: view

No data available for Pathways by source and SIGNOR curated interactions for NAA60 Gene

Drugs & Compounds for NAA60 Gene

(1) Drugs for NAA60 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for NAA60 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with NAA60: view

Transcripts for NAA60 Gene

Unigene Clusters for NAA60 Gene

N(alpha)-acetyltransferase 60, NatF catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA60 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -

Relevant External Links for NAA60 Gene

GeneLoc Exon Structure for
NAA60
ECgene alternative splicing isoforms for
NAA60

Expression for NAA60 Gene

mRNA expression in normal human tissues for NAA60 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NAA60 Gene



SOURCE GeneReport for Unigene cluster for NAA60 Gene Hs.513296

genes like me logo Genes that share expression patterns with NAA60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NAA60 Gene

Orthologs for NAA60 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA60 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAA60 35
  • 90.36 (n)
  • 95.87 (a)
NAA60 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NAA60 35
  • 91.87 (n)
  • 97.11 (a)
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Naa60 35
  • 93.25 (n)
  • 97.11 (a)
Naa60 16
Naa60 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Naa60 35
  • 92.84 (n)
  • 97.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves NAA60 35
  • 83.88 (n)
  • 90.91 (a)
-- 36
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naa60 35
  • 75.21 (n)
  • 80.99 (a)
zebrafish
(Danio rerio)
Actinopterygii nat15 35
  • 80.03 (n)
  • 88.84 (a)
nat15 36
  • 89 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005192 35
  • 57.75 (n)
  • 57.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Naa60 35
  • 55.95 (n)
  • 55.78 (a)
Naa60 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30F8.10 35
  • 46.67 (n)
  • 41.08 (a)
F30F8.10 36
  • 31 (a)
OneToMany
Species with no ortholog for NAA60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA60 Gene

ENSEMBL:
Gene Tree for NAA60 (if available)
TreeFam:
Gene Tree for NAA60 (if available)

Paralogs for NAA60 Gene

No data available for Paralogs for NAA60 Gene

Variants for NAA60 Gene

Sequence variations from dbSNP and Humsavar for NAA60 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34464545 - 3,484,780(-) AGGCT(C/G)TGGGC nc-transcript-variant, reference, missense
rs3859146 -- 3,447,839(+) GCCTT(A/G)AGTTG intron-variant
rs3859147 -- 3,450,193(+) TGTGC(C/T)AGTCT intron-variant
rs3859148 -- 3,450,717(+) aaaaa(A/G)aaaaa intron-variant
rs28401 -- 3,465,354(-) GACCA(C/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA60 Gene

Variant ID Type Subtype PubMed ID
esv29492 CNV Gain 19812545
nsv512420 CNV Loss 21212237
nsv1715 CNV Loss 18451855
nsv905213 CNV Loss 21882294
dgv361e201 CNV Deletion 23290073
dgv362e201 CNV Deletion 23290073
esv2750408 CNV Deletion 23290073
esv2665923 CNV Deletion 23128226
esv2750409 CNV Deletion 23290073
nsv905214 CNV Loss 21882294
nsv905215 CNV Loss 21882294

Variation tolerance for NAA60 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NAA60 Gene

Disorders for NAA60 Gene

Relevant External Links for NAA60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA60

No disorders were found for NAA60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA60 Gene

Publications for NAA60 Gene

  1. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. (PMID: 21750686) Van Damme P. … Arnesen T. (PLoS Genet. 2011) 2 3 4 67
  2. An organellar nI+-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H. … Arnesen T. (Cell Rep 2015) 2 3
  3. Holding it together: Naa60 at the Golgi. (PMID: 26164078) Aksnes H. … Arnesen T. (Oncotarget 2015) 3
  4. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (PMID: 24057671) Chimusa E.R. … Hoal E.G. (Hum. Mol. Genet. 2014) 3
  5. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PMID: 21593219) Nakabayashi K. … Monk D. (Hum. Mol. Genet. 2011) 3

Products for NAA60 Gene

Sources for NAA60 Gene

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