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Aliases for NAA60 Gene

Aliases for NAA60 Gene

  • N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit 2 3 5
  • N-Acetyltransferase 15 (GCN5-Related, Putative) 2 3
  • Histone Acetyltransferase Type B Protein 4 3 4
  • N-Alpha-Acetyltransferase F 3 4
  • HNaa60 3 4
  • NAT15 3 4
  • HAT4 3 4
  • NatF 3 4
  • N-Alpha-Acetyltransferase 60 3
  • N-Acetyltransferase 15 4
  • EC 2.3.1.259 4
  • EC 2.3.1.48 4

External Ids for NAA60 Gene

Previous HGNC Symbols for NAA60 Gene

  • NAT15

Previous GeneCards Identifiers for NAA60 Gene

  • GC16P003495

Summaries for NAA60 Gene

Entrez Gene Summary for NAA60 Gene

  • This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

GeneCards Summary for NAA60 Gene

NAA60 (N(Alpha)-Acetyltransferase 60, NatF Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA60 Gene

  • N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917).

Additional gene information for NAA60 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA60 Gene

Genomics for NAA60 Gene

Regulatory Elements for NAA60 Gene

Enhancers for NAA60 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H003400 1.1 ENCODE 11.9 -42.3 -42316 2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF597 CREBBP ZNF200 SRRM2 ZNF263 LOC105371055 ENSG00000261938 AMDHD2 ERVK13-1 NAA60
GH16H003455 1.1 ENCODE 11 +15.1 15141 6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CREBBP ZNF597 SRRM2 LOC105371055 ZNF263 ZNF200 AMDHD2 THOC6 ENSG00000261938 NAA60
GH16H003266 0.9 Ensembl dbSUPER 10.8 -176.6 -176611 0 GATAD2A CTCF PKNOX1 ZSCAN4 MAX ZNF2 RAD21 TEAD3 SMC3 ZNF143 ZNF75A ZNF200 TIGD7 NAA60 ZNF597 ZSCAN32 ZNF174 OR2C1 ZNF263 ENSG00000279330
GH16H003214 0.7 Ensembl ENCODE 10.7 -227.9 -227886 2 HLF HMBOX1 MEFV ZNF200 ZNF75A TIGD7 NAA60 ZNF597 ZNF174 ZSCAN32 OR2C1 C16orf90
GH16H003292 0.4 ENCODE 11.1 -150.8 -150806 0 ATF2 ZNF263 MEFV ZNF200 ZNF597 NAA60 ZNF174 ZSCAN32 ENSG00000279031 ENSG00000279330
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA60 on UCSC Golden Path with GeneCards custom track

Promoters for NAA60 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082642 -10 2000 ZFP64 SIN3A YY1 ETS1 ELK1 FOS RUNX3 SP3 MXD4 NFYC

Genomic Location for NAA60 Gene

Chromosome:
16
Start:
3,443,611 bp from pter
End:
3,486,963 bp from pter
Size:
43,353 bases
Orientation:
Plus strand

Genomic View for NAA60 Gene

Genes around NAA60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA60 Gene

Proteins for NAA60 Gene

  • Protein details for NAA60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X0-NAA60_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 60
    Protein Accession:
    Q9H7X0
    Secondary Accessions:
    • B3KRQ0
    • B4DLZ0
    • B4DPZ8
    • B4DYC4
    • D3DUC2
    • E7EQ65
    • Q6IA31
    • Q6UX26

    Protein attributes for NAA60 Gene

    Size:
    242 amino acids
    Molecular mass:
    27451 Da
    Quaternary structure:
    • Monomer and homodimer; monomer in presence of substrate and homodimer in its absence (PubMed:27320834).

    Three dimensional structures from OCA and Proteopedia for NAA60 Gene

    Alternative splice isoforms for NAA60 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA60 Gene

Post-translational modifications for NAA60 Gene

  • Acetylated: autoacetylation is required for optimal acetyltransferase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA60 Gene

Domains & Families for NAA60 Gene

Gene Families for NAA60 Gene

Protein Domains for NAA60 Gene

Suggested Antigen Peptide Sequences for NAA60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7X0

UniProtKB/Swiss-Prot:

NAA60_HUMAN :
  • Belongs to the acetyltransferase family. NAA60 subfamily.
Family:
  • Belongs to the acetyltransferase family. NAA60 subfamily.
genes like me logo Genes that share domains with NAA60: view

Function for NAA60 Gene

Molecular function for NAA60 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
UniProtKB/Swiss-Prot Function:
N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917).
UniProtKB/Swiss-Prot Induction:
Isoform 2: Imprinted (PubMed:21593219). Promoter methylation of the paternal allele may restrict expression to the maternal allele in placenta and leukocytes (PubMed:21593219). Isoform 1: Biallelically expressed (PubMed:21593219).

Enzyme Numbers (IUBMB) for NAA60 Gene

Phenotypes From GWAS Catalog for NAA60 Gene

Gene Ontology (GO) - Molecular Function for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IEA --
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 21750686
GO:0008080 N-acetyltransferase activity IEA --
GO:0010485 H4 histone acetyltransferase activity IDA 21981917
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NAA60: view
genes like me logo Genes that share phenotypes with NAA60: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA60

CRISPR Products

miRNA for NAA60 Gene

miRTarBase miRNAs that target NAA60

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAA60
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA60 Gene

Localization for NAA60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA60 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably forms a intramembrane hairpin-like structure in the membrane. {ECO:0000305 PubMed:25732826}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA60 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (1)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 21981917
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NAA60: view

Pathways & Interactions for NAA60 Gene

SuperPathways for NAA60 Gene

No Data Available

Interacting Proteins for NAA60 Gene

Gene Ontology (GO) - Biological Process for NAA60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IDA 21981917
GO:0006474 N-terminal protein amino acid acetylation IDA 25732826
GO:0007059 chromosome segregation ISS,IBA --
GO:0008283 cell proliferation IMP 21981917
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with NAA60: view

No data available for Pathways by source and SIGNOR curated interactions for NAA60 Gene

Drugs & Compounds for NAA60 Gene

(1) Drugs for NAA60 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for NAA60 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with NAA60: view

Transcripts for NAA60 Gene

Unigene Clusters for NAA60 Gene

N(alpha)-acetyltransferase 60, NatF catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAA60
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NAA60 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: -

Relevant External Links for NAA60 Gene

GeneLoc Exon Structure for
NAA60
ECgene alternative splicing isoforms for
NAA60

Expression for NAA60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA60 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAA60 Gene



NURSA nuclear receptor signaling pathways regulating expression of NAA60 Gene:

NAA60

SOURCE GeneReport for Unigene cluster for NAA60 Gene:

Hs.513296

Evidence on tissue expression from TISSUES for NAA60 Gene

  • Kidney(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NAA60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA60 Gene

Orthologs for NAA60 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
NAA60 33
  • 91.87 (n)
mouse
(Mus musculus)
Mammalia Naa60 33 16 34
  • 93.25 (n)
rat
(Rattus norvegicus)
Mammalia Naa60 33
  • 92.84 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NAA60 33 34
  • 90.36 (n)
chicken
(Gallus gallus)
Aves NAA60 33
  • 83.88 (n)
-- 34
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naa60 33
  • 75.21 (n)
zebrafish
(Danio rerio)
Actinopterygii nat15 33 34
  • 80.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005192 33
  • 57.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Naa60 33 34
  • 55.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F30F8.10 33 34
  • 46.67 (n)
Species where no ortholog for NAA60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA60 Gene

ENSEMBL:
Gene Tree for NAA60 (if available)
TreeFam:
Gene Tree for NAA60 (if available)

Paralogs for NAA60 Gene

No data available for Paralogs for NAA60 Gene

Variants for NAA60 Gene

Sequence variations from dbSNP and Humsavar for NAA60 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000001155 -- 3,474,158(+) CATGA(A/G)CTACT intron-variant
rs1000007986 -- 3,448,237(+) CCACT(G/T)CACTC intron-variant
rs1000055627 -- 3,443,745(+) GTCTT(A/C)GGGTG upstream-variant-2KB, utr-variant-5-prime
rs1000111807 -- 3,444,239(+) GGAGG(G/T)AGTGC intron-variant, upstream-variant-2KB
rs1000181126 -- 3,472,965(+) ACCTT(C/T)ATCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA60 Gene

Variant ID Type Subtype PubMed ID
dgv324e201 CNV deletion 23290073
dgv325e201 CNV deletion 23290073
esv2665923 CNV deletion 23128226
esv2750408 CNV deletion 23290073
esv2750409 CNV deletion 23290073
esv29492 CNV gain 19812545
esv3553026 CNV deletion 23714750
esv3637667 CNV gain 21293372
esv3637668 CNV loss 21293372
nsv1051957 CNV loss 25217958
nsv1070738 CNV deletion 25765185
nsv1148032 CNV deletion 26484159
nsv1715 CNV deletion 18451855
nsv512420 CNV loss 21212237
nsv952908 CNV deletion 24416366

Variation tolerance for NAA60 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA60 Gene

Disorders for NAA60 Gene

Relevant External Links for NAA60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA60

No disorders were found for NAA60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA60 Gene

Publications for NAA60 Gene

  1. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H … Arnesen T (Cell reports 2015) 2 3 4 60
  2. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. (PMID: 21750686) Van Damme P … Arnesen T (PLoS genetics 2011) 2 3 4 60
  3. Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. (PMID: 27320834) Støve SI … Arnesen T (Structure (London, England : 1993) 2016) 3 4 60
  4. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. (PMID: 27550639) Chen JY … Yun CH (Scientific reports 2016) 3 4 60
  5. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. (PMID: 21981917) Yang X … Shang Y (Molecular cell 2011) 3 4 60

Products for NAA60 Gene

Sources for NAA60 Gene

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