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Aliases for NAA50 Gene

Aliases for NAA50 Gene

  • N(Alpha)-Acetyltransferase 50, NatE Catalytic Subunit 2 3
  • NAT13 3 4 6
  • NAT5 3 4 6
  • N-Acetyltransferase 13 (GCN5-Related) 2 3
  • N-Acetyltransferase San Homolog 3 4
  • N-Acetyltransferase 13 2 4
  • NatE Catalytic Subunit 3 4
  • N-Acetyltransferase 5 3 4
  • HNAT5 3 4
  • MAK3 3 4
  • HSAN 3 4
  • SAN 3 6
  • N-Alpha-Acetyltransferase 50, NatE Catalytic Subunit 3
  • Mak3 Homolog (S. Cerevisiae) 2
  • N-Alpha-Acetyltransferase 50 3
  • Separation Anxiety 3
  • Mak3 Homolog 3
  • EC 2.3.1.- 4
  • NAT13P 3
  • NAT5P 3

External Ids for NAA50 Gene

Previous HGNC Symbols for NAA50 Gene

  • MAK3
  • NAT13

Previous GeneCards Identifiers for NAA50 Gene

  • GC03M113437
  • GC03M110812

Summaries for NAA50 Gene

GeneCards Summary for NAA50 Gene

NAA50 (N(Alpha)-Acetyltransferase 50, NatE Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Biological oxidations. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA50 Gene

  • Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA50 Gene

Genomics for NAA50 Gene

Genomic Location for NAA50 Gene

Start:
113,716,460 bp from pter
End:
113,746,300 bp from pter
Size:
29,841 bases
Orientation:
Minus strand

Genomic View for NAA50 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA50 Gene

No data available for Regulatory Elements for NAA50 Gene

Proteins for NAA50 Gene

  • Protein details for NAA50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ1-NAA50_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 50
    Protein Accession:
    Q9GZZ1
    Secondary Accessions:
    • D3DN74
    • Q68DQ1

    Protein attributes for NAA50 Gene

    Size:
    169 amino acids
    Molecular mass:
    19398 Da
    Quaternary structure:
    • Interacts with NAA35 (By similarity). Interacts with NAA15 and NAA11.

    Three dimensional structures from OCA and Proteopedia for NAA50 Gene

    Alternative splice isoforms for NAA50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA50 Gene

Proteomics data for NAA50 Gene at MOPED

Post-translational modifications for NAA50 Gene

  • Ubiquitination at Lys34, Lys37, Lys126, and Lys152
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAA50 Gene

Domains for NAA50 Gene

Gene Families for NAA50 Gene

HGNC:
  • NAA :N(alpha)-acetyltransferase subunits

Protein Domains for NAA50 Gene

Suggested Antigen Peptide Sequences for NAA50 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZZ1

UniProtKB/Swiss-Prot:

NAA50_HUMAN :
  • Q9GZZ1
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GNAT subfamily.
genes like me logo Genes that share domains with NAA50: view

Function for NAA50 Gene

Molecular function for NAA50 Gene

UniProtKB/Swiss-Prot Function: Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity.

Enzyme Numbers (IUBMB) for NAA50 Gene

Gene Ontology (GO) - Molecular Function for NAA50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 17502424
GO:0005515 protein binding IPI 16507339
GO:0008080 N-acetyltransferase activity --
GO:0010485 H4 histone acetyltransferase activity IDA 19744929
GO:0052858 peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA 19744929
genes like me logo Genes that share ontologies with NAA50: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAA50 Gene

Localization for NAA50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA50 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA50 Gene COMPARTMENTS Subcellular localization image for NAA50 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAA50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16507339
GO:0031415 colocalizes_with NatA complex IDA 16507339
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAA50: view

Pathways for NAA50 Gene

SuperPathways for NAA50 Gene

Superpath Contained pathways
1 Biological oxidations
genes like me logo Genes that share pathways with NAA50: view

Pathways by source for NAA50 Gene

1 BioSystems pathway for NAA50 Gene

Gene Ontology (GO) - Biological Process for NAA50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation TAS 16507339
GO:0008152 metabolic process --
GO:0043967 histone H4 acetylation IDA 19744929
GO:0071962 mitotic sister chromatid cohesion, centromeric IDA 17502424
genes like me logo Genes that share ontologies with NAA50: view

Transcripts for NAA50 Gene

Unigene Clusters for NAA50 Gene

N(alpha)-acetyltransferase 50, NatE catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA50 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for NAA50 Gene

GeneLoc Exon Structure for
NAA50
ECgene alternative splicing isoforms for
NAA50

Expression for NAA50 Gene

mRNA expression in normal human tissues for NAA50 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAA50 Gene

This gene is overexpressed in Muscle - Skeletal (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA50 Gene

SOURCE GeneReport for Unigene cluster for NAA50 Gene Hs.372378

genes like me logo Genes that share expressions with NAA50: view

No data available for mRNA Expression by UniProt/SwissProt for NAA50 Gene

Orthologs for NAA50 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA50 35
  • 100 (n)
  • 100 (a)
NAA50 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA50 35
  • 95.07 (n)
  • 100 (a)
NAA50 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA50 35
  • 98.03 (n)
  • 100 (a)
NAA50 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa50 35
  • 92.26 (n)
  • 98.81 (a)
Naa50 16
Naa50 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA50 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAA50 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa50 35
  • 92.06 (n)
  • 97.02 (a)
chicken
(Gallus gallus)
Aves NAA50 35
  • 89.47 (n)
  • 99.34 (a)
NAA50 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA50 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24370 35
tropical clawed frog
(Silurana tropicalis)
Amphibia naa50 35
  • 82.74 (n)
  • 97.62 (a)
Str.7260 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8499 35
zebrafish
(Danio rerio)
Actinopterygii naa50 35
  • 80.24 (n)
  • 93.41 (a)
naa50 36
  • 93 (a)
OneToOne
wufb01d06 35
fruit fly
(Drosophila melanogaster)
Insecta san 36
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F40F4.7 36
  • 31 (a)
OneToMany
F54E7.9 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT5 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.735 35
Species with no ortholog for NAA50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA50 Gene

ENSEMBL:
Gene Tree for NAA50 (if available)
TreeFam:
Gene Tree for NAA50 (if available)

Paralogs for NAA50 Gene

Pseudogenes.org Pseudogenes for NAA50 Gene

genes like me logo Genes that share paralogs with NAA50: view

No data available for Paralogs for NAA50 Gene

Variants for NAA50 Gene

Sequence variations from dbSNP and Humsavar for NAA50 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs15781 -- 113,721,674(+) TAAAA(A/G/T)AAAAG utr-variant-3-prime
rs921741 -- 113,725,204(+) CTTCA(A/C)TACTG intron-variant
rs1049157 -- 113,719,133(-) GAAAA(A/G)AAAAG utr-variant-3-prime
rs1349942 -- 113,718,763(+) TTTCC(C/T)TCTCA utr-variant-3-prime, downstream-variant-500B
rs1378180 -- 113,718,765(+) TCCCT(C/T)TCATT utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NAA50 Gene

Variant ID Type Subtype PubMed ID
nsv519099 CNV Loss 19592680
nsv829678 CNV Loss 17160897
nsv877351 CNV Loss 21882294

Relevant External Links for NAA50 Gene

HapMap Linkage Disequilibrium report
NAA50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA50 Gene

Disorders for NAA50 Gene

(1) University of Copenhagen DISEASES for NAA50 Gene

genes like me logo Genes that share disorders with NAA50: view

No data available for UniProtKB/Swiss-Prot for NAA50 Gene

Publications for NAA50 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4
  2. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. (PMID: 16507339) Arnesen T. … Lillehaug J.R. (Gene 2006) 2 3 4
  3. The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. (PMID: 17502424) Hou F. … Zou H. (J. Cell Biol. 2007) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for NAA50 Gene

  • Addgene plasmids for NAA50

Sources for NAA50 Gene

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