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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAA40 Gene

protein-coding   GIFtS: 45
GCID: GC11P063706

N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit

(Previous names: N-acetyltransferase 11, N-acetyltransferase 11 (GCN5-related,...)
(Previous symbol: NAT11)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit1 2     PATT12
NAT111 2 3     N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog2
N-Acetyltransferase 11 (GCN5-Related, Putative)1 2     N-Alpha Acetyl Transferase 402
N-Acetyltransferase 111 3     N-Alpha-Acetyltransferase 402
NatD Catalytic Subunit2 3     N-Alpha-Acetyltransferase 40, NatD Catalytic Subunit2
N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog (S.
Cerevisiae)1
     EC 2.3.1.-3

External Ids:    HGNC: 258451   Entrez Gene: 798292   Ensembl: ENSG000001105837   UniProtKB: Q86UY63   

Export aliases for NAA40 gene to outside databases

Previous GC identifer: GC11P060036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NAA40 Gene: 
NAA40 (N(alpha)-acetyltransferase 40, NatD catalytic subunit) is a protein-coding gene. Diseases associated with NAA40 include hepatocellular carcinoma, and among its related super-pathways are Biological oxidations. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot: NAA40_HUMAN, Q86UY6
Function: Responsible for the acetylation of the N-terminal residues of histones H4 and H2A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NAA40
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAA40 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAA40

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

NAA40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAA40 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063706:  view genomic region     (about GC identifiers)

Start:
63,706,431 bp from pter      End:
63,724,800 bp from pter
Size:
18,370 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NAA40_HUMAN, Q86UY6 (See protein sequence)
Recommended Name: N-alpha-acetyltransferase 40  
Size: 237 amino acids; 27194 Da
Sequence caution: Sequence=CAI46006.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q5HYL5 Q9H897

Explore the universe of human proteins at neXtProt for NAA40: NX_Q86UY6

Explore proteomics data for NAA40 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UY6

  • NAA40 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAA40 Protein Expression
    REFSEQ proteins: NP_079047.2  
    ENSEMBL proteins: 
     ENSP00000440304   ENSP00000367024   ENSP00000438639   ENSP00000440849   ENSP00000442055  
     ENSP00000407578  

    Human Recombinant Protein Products for NAA40: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NAA: N(alpha)-acetyltransferase subunits

    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q86UY6

    ProtoNet protein and cluster: Q86UY6

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: NAA40_HUMAN, Q86UY6
    Similarity: Belongs to the acetyltransferase family. GNAT subfamily
    Similarity: Contains 1 N-acetyltransferase domain


    NAA40 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAA40_HUMAN, Q86UY6
    Function: Responsible for the acetylation of the N-terminal residues of histones H4 and H2A

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008080N-acetyltransferase activity IEA--
         
    NAA40 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Naa40):
     adipose tissue  behavior/neurological  cellular  growth/size  homeostasis/metabolism 
     liver/biliary system 

    NAA40 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAA40 
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    miRNA
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    miRTarBase miRNAs that target NAA40:
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate NAA40 (see all 29):
    hsa-miR-320a hsa-miR-125a-5p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-373* hsa-miR-3142 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidNAA40 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NAA40 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.41


    1 BioSystems Pathway for NAA40
        metapathway biotransformation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA40

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAA40

    Search CenterWatch for drugs/clinical trials and news about NAA40

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAA40 gene: 
    NM_024771.2  

    Unigene Cluster for NAA40:

    N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
    Hs.523753  [show with all ESTs]
    Unigene Representative Sequence: BX647309
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338447(uc009yoz.3 uc010rmw.2) ENST00000536939 ENST00000534965
    ENST00000377793(uc010rmx.2 uc010rmy.2) ENST00000539656 ENST00000544138
    ENST00000542163 ENST00000545161 ENST00000544194 ENST00000542633 ENST00000456907

    miRNA
    Products:
         
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate NAA40 (see all 29):
    hsa-miR-320a hsa-miR-125a-5p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-373* hsa-miR-3142 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidNAA40 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAA40
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAA40

    Additional mRNA sequence: 

    AK023910.1 AK299041.1 AK300451.1 AK303557.1 BC024160.2 BC041617.1 BC052298.1 BX647309.1 
    JF263566.1 

    7 DOTS entries:

    DT.425052  DT.434455  DT.100784383  DT.100784384  DT.120727791  DT.430191  DT.95123746 

    24/134 AceView cDNA sequences (see all 134):

    BM836913 BE206497 BF184781 BC052298 BC041617 AA308371 BQ061970 AU130059 
    BQ643116 BQ057333 AI365998 BM827572 AU124159 BQ642457 BM020459 BM823419 
    BG687609 AI538555 NM_024771 BG529480 AW007427 AW517815 BE537055 BG492544 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NAA40 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                -     -     -           -                 -                           
    SP2:                                                        -                 -                           
    SP3:                                -     -     -           -                                             
    SP4:                                -                       -     -     -     -     -                     
    SP5:                                -     -     -           -     -     -     -     -                     


    ECgene alternative splicing isoforms for NAA40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAA40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAAGCCC
    NAA40 Expression
    About this image


    See NAA40 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAA40

    SOURCE GeneReport for Unigene cluster: Hs.523753
        SABiosciences Custom PCR Arrays for NAA40
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAA40 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naa401 , 5 N(alpha)-acetyltransferase 40, NatD catalytic subunit, more1, 5 91.42(n)1
    98.73(a)1
      19 (5.29 cM)5
    709991  NM_027643.11  NP_081919.11 
     72256685 
    chicken
    (Gallus gallus)
    Aves NAA401 N(alpha)-acetyltransferase 40, NatD catalytic subunit, more 80.57(n)
    86.81(a)
      430563  XM_003643528.1  XP_003643576.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAA406
    N(alpha)-acetyltransferase 40, NatD catalytic subu...
    89(a)
    1 ↔ 1
    GL343699.1(248292-259192)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163732 Xenopus laevis transcribed sequence with moderate similarity more 77.34(n)    CA974352.1 
    zebrafish
    (Danio rerio)
    Actinopterygii naa401 N(alpha)-acetyltransferase 40, NatD catalytic subunit, more 75(n)
    84.75(a)
      550325  NM_001017632.1  NP_001017632.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG75931 CG7593 49.18(n)
    36.61(a)
      43500  NM_143458.2  NP_651715.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38A10A.71 Protein Y38A10A.7 43.76(n)
    30.06(a)
      260224  NM_072172.1  NP_504573.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G183351 acyl-CoA N-acyltransferases-like protein 45.02(n)
    36.97(a)
      838414  NM_148472.2  NP_683313.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g03878001 hypothetical protein 46.73(n)
    37.25(a)
      4338664  NM_001061961.1  NP_001055426.1 


    ENSEMBL Gene Tree for NAA40 (if available)
    TreeFam Gene Tree for NAA40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAA40 gene

    NAA40 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAA40
    PGOHUM00000243474


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in NAA40 are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812598131,2
    --63704498(+) TTTGCA/GGAGAC 1 -- us2k10--------
    rs122840071,2
    C,F--63704606(+) cactgC/Tgccag 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs79275181,2
    C,A--63704681(+) gtatcT/Attttt 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs561943971,2
    C--63704681(+) TTTTT-/TGAGAC 1 -- us2k10--------
    rs71111301,2
    C,F,A--63704817(+) acaggC/Tgcccg 1 -- us2k15Minor allele frequency- T:0.01NA EA CSA 179
    rs1849318251,2
    C--63704955(+) AGGCGC/TGAGCC 1 -- us2k10--------
    rs1897503161,2
    --63705024(+) ATCTAC/TTATCG 1 -- us2k10--------
    rs1830701481,2
    --63705101(+) TGGAAC/TAGTGC 1 -- us2k10--------
    rs1862408551,2
    --63705136(+) AATGTC/TGTTGA 1 -- us2k10--------
    rs1383041601,2
    --63705145(+) GAGGCC/TACCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAA40 (63706431 - 63724800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NAA40:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1156n71CNV Loss21882294
    dgv1155n71CNV Loss21882294
    nsv897639CNV Loss21882294
    nsv825941CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NAA40
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NAA40:    About MalaCards
    hepatocellular carcinoma    


    NAA40 for disorders           About GeneDecksing


    Export disorders for NAA40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAA40 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with NAA40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
    2. The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. (PubMed id 21935442)1, 2 Hole K....Arnesen T. (2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Patt1, a novel protein acetyltransferase that is high ly expressed in liver and downregulated in hepatocellular carcinoma, enhances a poptosis of hepatoma cells. (PubMed id 19695338)1 Liu Z....Zhai Q. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79829 HGNC: 25845 AceView: FLJ13848 Ensembl:ENSG00000110583 euGenes: HUgn79829
    ECgene: NAA40 H-InvDB: NAA40

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for NAA40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for NAA40 gene:
    Search GeneIP for patents involving NAA40

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