NAA40 Gene
protein-coding GIFtS: 44
GCID: GC11P063706
|
|
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog...(Previous names: N-acetyltransferase 11, N-acetyltransferase 11 (GCN5-related,...)
(Previous symbol: NAT11)
| |
Aliases
for NAA40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog (S.Cerevisiae)1 2 | | PATT12 | | NAT111 2 3 | | N-Alpha Acetyl Transferase 402 | | N-Acetyltransferase 11 (GCN5-Related, Putative)1 2 | | N-Alpha-Acetyltransferase 402 | | N-Acetyltransferase 111 3 | | N-Alpha-Acetyltransferase 40, NatD Catalytic Subunit2 | | NatD Catalytic Subunit2 3 | | EC 2.3.1.-3 | | FLJ138481 | | |
Export aliases for NAA40 gene to outside databasesPrevious GC identifer: GC11P060036 |
Summaries
for NAA40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NAA40_HUMAN, Q86UY6Function: Responsible for the acetylation of the N-terminal residues of histones H4 and H2A
|
Genomic Views
for NAA40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NAA40
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAA40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1NAA40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P063706: view genomic region
(about GC identifiers)
Start:
|
63,706,431 bp from pter |
End:
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63,724,800 bp from pter |
Size:
|
18,370 bases |
Orientation:
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plus strand |
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Proteins
for NAA40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAA40_HUMAN, Q86UY6 (See
protein sequence)Recommended Name: N-alpha-acetyltransferase 40 Size: 237 amino acids; 27194 Da
Sequence caution: Sequence=CAI46006.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q5HYL5 Q9H897Explore the universe of human proteins at neXtProt for NAA40: NX_Q86UY6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UY6
NAA40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079047.2
ENSEMBL proteins: ENSP00000440304 ENSP00000367024 ENSP00000438639 ENSP00000440849 ENSP00000442055 ENSP00000407578
Human Recombinant Protein Products for NAA40:
NAA40 Antibody Products:
Assay Products for NAA40: |
Protein
Domains /
Families
for NAA40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAA40 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86UY6ProtoNet protein and cluster: Q86UY6 1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase
UniProtKB/Swiss-Prot: NAA40_HUMAN, Q86UY6Similarity: Belongs to the acetyltransferase family. GNAT subfamilySimilarity: Contains 1 N-acetyltransferase domain |
Function
for NAA40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NAA40_HUMAN, Q86UY6Function: Responsible for the acetylation of the N-terminal residues of histones H4 and H2A Enzyme Number (IUBMB): EC 2.3.1.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008080 | N-acetyltransferase activity |
IEA | -- |
NAA40 for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Naa40):
NAA40 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA40
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NAA40 (NM_024771) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAA40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA40 |
|
Pathways & Interactions
for NAA40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Biological oxidations | |
1  BioSystems Pathway for NAA40
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA40
|
Drugs & Compounds
for NAA40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAA40
Search CenterWatch for drugs/clinical trials and news about NAA40
|
Transcripts
for NAA40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAA40 gene: NM_024771.2 Unigene Cluster for NAA40: N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae) Hs.523753 [show with all ESTs]Unigene Representative Sequence: BX64730911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338447(uc009yoz.3 uc010rmw.2) ENST00000536939 ENST00000534965
ENST00000377793(uc010rmx.2 uc010rmy.2) ENST00000539656 ENST00000544138
ENST00000542163 ENST00000545161 ENST00000544194 ENST00000542633 ENST00000456907
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA40
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAA40 (NM_024771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAA40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA40 |
Additional cDNA sequence: AK023910.1 AK299041.1 AK300451.1 AK303557.1 BC024160.2 BC041617.1 BC052298.1 BX647309.1 JF263566.1 7 DOTS entries: DT.425052 DT.434455 DT.100784383 DT.100784384 DT.120727791 DT.430191 DT.95123746 24/134 AceView cDNA sequences (see all 134): BM823419 AU130059 BM836913 BQ057333 BQ643116 BF184781 BQ061970 BQ642457 BM827572 AA308371 BC041617 BM020459 AU124159 BC052298 BE206497 AI365998 BG687609 BQ945613 AW962466 AI061320 H88367 AI689228 BE710396 AW369430
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NAA40 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
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| SP1: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for NAA40
|
Expression
for NAA40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAA40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAAAGCCC
About this image
See NAA40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAA40
SOURCE GeneReport for Unigene cluster: Hs.523753
SABiosciences Custom PCR Arrays for NAA40
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAA40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAA40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAA40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA40 |
Orthologs
for NAA40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAA40 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for NAA40 (if available)
TreeFam Gene Tree for NAA40 (if available) |
Paralogs
for NAA40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAA40 gene
NAA40 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NAA40
PGOHUM00000243474
|
Genomic Variants
for NAA40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAA40 (63706431 - 63724800 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAA40: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAA40 |
|
Disorders
/ Diseases
for NAA40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAA40 for disorders About GeneDecksing
3  diseases for NAA40: About MalaCardshepatocellular carcinoma carcinoma malaria
Export disorders for NAA40 gene to outside databases
|
Publications
for NAA40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAA40 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NAA40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
- The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. (PubMed id 21935442)1, 2 Hole K....Arnesen T. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Patt1, a novel protein acetyltransferase that is high ly expressed in liver and downregulated in hepatocellular carcinoma, enhances a poptosis of hepatoma cells. (PubMed id 19695338)1 Liu Z....Zhai Q. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for NAA40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAA40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAA40 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAA40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAA40 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAA40 gene:
Search GeneIP for patents involving NAA40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAA40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NAA40 | | OriGene shRNA RFP for NAA40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAA40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA40 | | | OriGene Protein Over-expression Lysate for NAA40 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAA40 | | OriGene 3'-UTR Clone for NAA40 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NAA40 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAA40 | | OriGene Custom Protein Services for NAA40 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAA40 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAA40 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA40 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAA40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAA40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAA40 |
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| | | | Search Tocris compounds for NAA40 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA40 |
|  |  |  |  | | | | ThermoFisher Antibodies for NAA40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA40 |
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