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Aliases for NAA40 Gene

Aliases for NAA40 Gene

  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit 2 3 5
  • N-Acetyltransferase 11 (GCN5-Related, Putative) 2 3
  • N-Acetyltransferase 11 2 4
  • NatD Catalytic Subunit 3 4
  • NAT11 3 4
  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog (S. Cerevisiae) 2
  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog 3
  • N-Alpha Acetyl Transferase 40 3
  • N-Alpha-Acetyltransferase 40 3
  • EC 2.3.1.- 4
  • PATT1 3

External Ids for NAA40 Gene

Previous HGNC Symbols for NAA40 Gene

  • NAT11

Previous GeneCards Identifiers for NAA40 Gene

  • GC11P063706
  • GC11P060036

Summaries for NAA40 Gene

GeneCards Summary for NAA40 Gene

NAA40 (N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA40 Gene

  • Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA40 Gene

Genomics for NAA40 Gene

Regulatory Elements for NAA40 Gene

Enhancers for NAA40 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F063865 1.3 Ensembl ENCODE 17.7 -68.8 -68832 10.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 YY1 SLC30A9 ZNF143 NAA40 MARK2 C11orf84 RTN3 PLA2G16 LOC105369340 GC11M063862 RNU6-1306P
GH11F063837 1.6 FANTOM5 Ensembl ENCODE 12.2 -98.4 -98393 6.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 NAA40 RNU6-1306P MARK2 CCND2P1 COX8A FERMT3 RTN3 LGALS12 GC11M063862
GH11F064183 1.4 FANTOM5 ENCODE 9.7 +246.7 246715 4.4 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 C11orf84 TRPT1 IMMP1LP1 ENSG00000269038 FERMT3 C11orf95 ENSG00000257086 PLCB3 ENSG00000256341 SNX15
GH11F063854 1.2 Ensembl ENCODE 11.3 -81.3 -81282 5.6 PKNOX1 ATF1 ARID4B SIN3A ZNF48 BRCA1 FOS NFYC ZHX2 TBX21 RNU6-1306P NAA40 ENSG00000269038 ENSG00000256341 PLA2G16 C11orf84 LOC105369340 GC11M063862 MARK2
GH11F063862 1.1 Ensembl ENCODE 11.5 -76.0 -76017 1.4 ELF3 MLX ARID4B ZNF48 ZSCAN9 RAD21 RARA MIXL1 THAP11 MXD4 MARK2 NAA40 C11orf84 RTN3 ENSG00000256341 COX8A GC11M063862 RNU6-1306P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA40 on UCSC Golden Path with GeneCards custom track

Promoters for NAA40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000319509 141 2201 HDGF ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 ZNF263 SP3 SP5

Genomic Location for NAA40 Gene

63,938,959 bp from pter
63,957,328 bp from pter
18,370 bases
Plus strand

Genomic View for NAA40 Gene

Genes around NAA40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA40 Gene

Proteins for NAA40 Gene

  • Protein details for NAA40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-alpha-acetyltransferase 40
    Protein Accession:
    Secondary Accessions:
    • B4DR03
    • B4DU10
    • Q5HYL5
    • Q9H897

    Protein attributes for NAA40 Gene

    237 amino acids
    Molecular mass:
    27194 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI46006.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAA40 Gene

    Alternative splice isoforms for NAA40 Gene


neXtProt entry for NAA40 Gene

Post-translational modifications for NAA40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA40 Gene

Domains & Families for NAA40 Gene

Protein Domains for NAA40 Gene

Suggested Antigen Peptide Sequences for NAA40 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. GNAT subfamily.
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. GNAT subfamily.
genes like me logo Genes that share domains with NAA40: view

Function for NAA40 Gene

Molecular function for NAA40 Gene

UniProtKB/Swiss-Prot Function:
Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.

Enzyme Numbers (IUBMB) for NAA40 Gene

Gene Ontology (GO) - Molecular Function for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IEA --
GO:0004596 peptide alpha-N-acetyltransferase activity IEA --
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAA40: view
genes like me logo Genes that share phenotypes with NAA40: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA40

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA40 Gene

Localization for NAA40 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA40 gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NAA40 Gene

Pathways & Interactions for NAA40 Gene

genes like me logo Genes that share pathways with NAA40: view

Pathways by source for NAA40 Gene

1 BioSystems pathway for NAA40 Gene

Gene Ontology (GO) - Biological Process for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with NAA40: view

No data available for SIGNOR curated interactions for NAA40 Gene

Transcripts for NAA40 Gene

Unigene Clusters for NAA40 Gene

N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA40 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - -

Relevant External Links for NAA40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAA40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA40 Gene

Protein differential expression in normal tissues from HIPED for NAA40 Gene

This gene is overexpressed in Fetal heart (42.0) and Fetal testis (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA40 Gene

Protein tissue co-expression partners for NAA40 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAA40 Gene:


SOURCE GeneReport for Unigene cluster for NAA40 Gene:

genes like me logo Genes that share expression patterns with NAA40: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA40 Gene

Orthologs for NAA40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA40 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAA40 34 35
  • 99.72 (n)
(Bos Taurus)
Mammalia NAT11 35
  • 98 (a)
NAA40 34
  • 91.98 (n)
(Canis familiaris)
Mammalia NAA40 34 35
  • 92.95 (n)
(Rattus norvegicus)
Mammalia Naa40 34
  • 91.7 (n)
(Mus musculus)
Mammalia Naa40 34 16 35
  • 91.42 (n)
(Ornithorhynchus anatinus)
Mammalia NAA40 35
  • 88 (a)
(Monodelphis domestica)
Mammalia NAA40 35
  • 55 (a)
(Gallus gallus)
Aves NAA40 34 35
  • 80.57 (n)
(Anolis carolinensis)
Reptilia NAA40 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia naa40 34
  • 73.87 (n)
Str.2069 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16373 34
(Danio rerio)
Actinopterygii naa40 34 35 35
  • 75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008428 34
  • 51.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7593 34 35
  • 49.18 (n)
(Caenorhabditis elegans)
Secernentea Y38A10A.7 34 35
  • 44.79 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18335 34
  • 45.93 (n)
(Oryza sativa)
Liliopsida Os05g0387800 34
  • 46.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
Species where no ortholog for NAA40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA40 Gene

Gene Tree for NAA40 (if available)
Gene Tree for NAA40 (if available)

Paralogs for NAA40 Gene Pseudogenes for NAA40 Gene

genes like me logo Genes that share paralogs with NAA40: view

No data available for Paralogs for NAA40 Gene

Variants for NAA40 Gene

Sequence variations from dbSNP and Humsavar for NAA40 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1055933 -- 63,956,703(+) agtgc(A/G)gtggc utr-variant-3-prime
rs1059205 -- 63,957,195(+) TGATA(C/T)ATATA utr-variant-3-prime
rs1059206 -- 63,957,212(+) TATAT(A/T)TTTTT utr-variant-3-prime
rs10618202 -- 63,940,064(+) TTTTT(-/TTTT)GATAT intron-variant
rs10708670 -- 63,950,123(+) TTTTG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA40 Gene

Variant ID Type Subtype PubMed ID
nsv555180 CNV loss 21841781
nsv555181 CNV loss 21841781
nsv825941 CNV gain 20364138
nsv951010 CNV deletion 24416366

Variation tolerance for NAA40 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA40 Gene

Disorders for NAA40 Gene

Relevant External Links for NAA40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAA40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA40 Gene

Publications for NAA40 Gene

  1. The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. (PMID: 21935442) Hole K. … Arnesen T. (PLoS ONE 2011) 2 3 4 64
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. (PMID: 26666750) Pavlou D. … Kirmizis A. (Apoptosis 2016) 3 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for NAA40 Gene

Sources for NAA40 Gene

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