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Aliases for NAA40 Gene

Aliases for NAA40 Gene

  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit 2 3
  • N-Acetyltransferase 11 (GCN5-Related, Putative) 2 3
  • N-Acetyltransferase 11 2 4
  • NatD Catalytic Subunit 3 4
  • NAT11 3 4
  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog (S. Cerevisiae) 2
  • N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit, Homolog 3
  • N-Alpha-Acetyltransferase 40, NatD Catalytic Subunit 3
  • N-Alpha Acetyl Transferase 40 3
  • N-Alpha-Acetyltransferase 40 3
  • EC 2.3.1.- 4
  • PATT1 3

External Ids for NAA40 Gene

Previous HGNC Symbols for NAA40 Gene

  • NAT11

Previous GeneCards Identifiers for NAA40 Gene

  • GC11P063706
  • GC11P060036

Summaries for NAA40 Gene

GeneCards Summary for NAA40 Gene

NAA40 (N(Alpha)-Acetyltransferase 40, NatD Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Biological oxidations. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA40 Gene

  • Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA40 Gene

Genomics for NAA40 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAA40 Gene

Start:
63,938,959 bp from pter
End:
63,957,328 bp from pter
Size:
18,370 bases
Orientation:
Plus strand

Genomic View for NAA40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA40 Gene

No data available for Regulatory Elements for NAA40 Gene

Proteins for NAA40 Gene

  • Protein details for NAA40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UY6-NAA40_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 40
    Protein Accession:
    Q86UY6
    Secondary Accessions:
    • B4DR03
    • B4DU10
    • Q5HYL5
    • Q9H897

    Protein attributes for NAA40 Gene

    Size:
    237 amino acids
    Molecular mass:
    27194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI46006.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAA40 Gene

    Alternative splice isoforms for NAA40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA40 Gene

Proteomics data for NAA40 Gene at MOPED

Post-translational modifications for NAA40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA40 Gene

No data available for DME Specific Peptides for NAA40 Gene

Domains for NAA40 Gene

Gene Families for NAA40 Gene

HGNC:
  • NAA :N(alpha)-acetyltransferase subunits

Protein Domains for NAA40 Gene

Suggested Antigen Peptide Sequences for NAA40 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UY6

UniProtKB/Swiss-Prot:

NAA40_HUMAN :
  • Q86UY6
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GNAT subfamily.
genes like me logo Genes that share domains with NAA40: view

Function for NAA40 Gene

Molecular function for NAA40 Gene

UniProtKB/Swiss-Prot Function: Responsible for the acetylation of the N-terminal residues of histones H4 and H2A.

Enzyme Numbers (IUBMB) for NAA40 Gene

Gene Ontology (GO) - Molecular Function for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with NAA40: view
genes like me logo Genes that share phenotypes with NAA40: view

Animal Model Products

CRISPR Products

miRNA for NAA40 Gene

miRTarBase miRNAs that target NAA40

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAA40

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NAA40 Gene

Localization for NAA40 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA40 Gene COMPARTMENTS Subcellular localization image for NAA40 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NAA40 Gene

Pathways for NAA40 Gene

SuperPathways for NAA40 Gene

Superpath Contained pathways
1 Biological oxidations
genes like me logo Genes that share pathways with NAA40: view

Pathways by source for NAA40 Gene

1 BioSystems pathway for NAA40 Gene

Interacting Proteins for NAA40 Gene

Gene Ontology (GO) - Biological Process for NAA40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with NAA40: view

Transcripts for NAA40 Gene

Unigene Clusters for NAA40 Gene

N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAA40

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA40 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for NAA40 Gene

GeneLoc Exon Structure for
NAA40
ECgene alternative splicing isoforms for
NAA40

Expression for NAA40 Gene

mRNA expression in normal human tissues for NAA40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA40 Gene

SOURCE GeneReport for Unigene cluster for NAA40 Gene Hs.523753

genes like me logo Genes that share expressions with NAA40: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA40 Gene

Orthologs for NAA40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA40 35
  • 99.72 (n)
  • 100 (a)
NAA40 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA40 35
  • 91.98 (n)
  • 98.31 (a)
NAT11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA40 35
  • 92.95 (n)
  • 98.56 (a)
NAA40 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa40 35
  • 91.42 (n)
  • 98.73 (a)
Naa40 16
Naa40 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA40 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAA40 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa40 35
  • 91.7 (n)
  • 97.89 (a)
chicken
(Gallus gallus)
Aves NAA40 35
  • 80.57 (n)
  • 86.81 (a)
NAA40 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA40 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16373 35
tropical clawed frog
(Silurana tropicalis)
Amphibia naa40 35
  • 73.87 (n)
  • 81.36 (a)
Str.2069 35
zebrafish
(Danio rerio)
Actinopterygii naa40 35
  • 75 (n)
  • 84.75 (a)
naa40 36
  • 78 (a)
OneToMany
naa40 36
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008428 35
  • 51.55 (n)
  • 37.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7593 35
  • 49.18 (n)
  • 36.61 (a)
CG7593 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y38A10A.7 35
  • 44.79 (n)
  • 31.29 (a)
Y38A10A.7 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18335 35
  • 45.93 (n)
  • 37.8 (a)
rice
(Oryza sativa)
Liliopsida Os05g0387800 35
  • 46.06 (n)
  • 38.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for NAA40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA40 Gene

ENSEMBL:
Gene Tree for NAA40 (if available)
TreeFam:
Gene Tree for NAA40 (if available)

Paralogs for NAA40 Gene

Pseudogenes.org Pseudogenes for NAA40 Gene

genes like me logo Genes that share paralogs with NAA40: view

No data available for Paralogs for NAA40 Gene

Variants for NAA40 Gene

Sequence variations from dbSNP and Humsavar for NAA40 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs320126 -- 63,956,828(-) TGGCT(A/G)ATTTT utr-variant-3-prime
rs320127 -- 63,956,473(-) CCACG(C/T)ATCCA utr-variant-3-prime
rs728919 -- 63,941,102(-) AGGAA(A/G)CAAGG intron-variant
rs873928 -- 63,939,002(+) GGGCC(A/C/G)TCCGC upstream-variant-2KB, utr-variant-5-prime
rs901492 -- 63,940,512(-) GGTAT(A/C/T)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA40 Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
nsv897639 CNV Loss 21882294
nsv825941 CNV Gain 20364138

Relevant External Links for NAA40 Gene

HapMap Linkage Disequilibrium report
NAA40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA40 Gene

Disorders for NAA40 Gene

No disorders were found for NAA40 Gene.

No data available for UniProtKB/Swiss-Prot for NAA40 Gene

Publications for NAA40 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. (PMID: 21935442) Hole K. … Arnesen T. (PLoS ONE 2011) 3 4
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Structure of Patt1 human proapoptotic histone acetyltransferase. (PMID: 24248912) JA9drzejewski R.P. … KaA_mierkiewicz R. (J Mol Model 2013) 3

Products for NAA40 Gene

Sources for NAA40 Gene

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