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Aliases for NAA38 Gene

Aliases for NAA38 Gene

  • N(Alpha)-Acetyltransferase 38, NatC Auxiliary Subunit 2 3 5
  • Phosphonoformate Immuno-Associated Protein 2 3 4
  • LSM Domain-Containing Protein 1 3 4
  • LSM Domain Containing 1 2 3
  • PFAAP2 3 4
  • LSMD1 3 4
  • MAK31 4

External Ids for NAA38 Gene

Previous HGNC Symbols for NAA38 Gene

  • LSMD1

Previous GeneCards Identifiers for NAA38 Gene

  • GC07P117824
  • GC07P112190
  • GC17M007763

Summaries for NAA38 Gene

GeneCards Summary for NAA38 Gene

NAA38 (N(Alpha)-Acetyltransferase 38, NatC Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for NAA38 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA38 Gene

Genomics for NAA38 Gene

Regulatory Elements for NAA38 Gene

Enhancers for NAA38 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAA38 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA38 Gene

7,856,685 bp from pter
7,885,283 bp from pter
28,599 bases
Minus strand

Genomic View for NAA38 Gene

Genes around NAA38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA38 Gene

Proteins for NAA38 Gene

  • Protein details for NAA38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-alpha-acetyltransferase 38, NatC auxiliary subunit
    Protein Accession:
    Secondary Accessions:
    • Q8N4M0

    Protein attributes for NAA38 Gene

    125 amino acids
    Molecular mass:
    13514 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

    Alternative splice isoforms for NAA38 Gene


neXtProt entry for NAA38 Gene

Proteomics data for NAA38 Gene at MOPED

Post-translational modifications for NAA38 Gene

  • Ubiquitination at Lys 51 and Lys 86
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAA38 Gene

Domains & Families for NAA38 Gene

Gene Families for NAA38 Gene

Suggested Antigen Peptide Sequences for NAA38 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the snRNP Sm proteins family.
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with NAA38: view

Function for NAA38 Gene

Molecular function for NAA38 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
genes like me logo Genes that share phenotypes with NAA38: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA38 Gene

Localization for NAA38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA38 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for NAA38 Gene COMPARTMENTS Subcellular localization image for NAA38 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19398576
GO:0031417 NatC complex IDA 19398576
genes like me logo Genes that share ontologies with NAA38: view

Pathways & Interactions for NAA38 Gene

genes like me logo Genes that share pathways with NAA38: view

Gene Ontology (GO) - Biological Process for NAA38 Gene


No data available for SIGNOR curated interactions for NAA38 Gene

Drugs & Compounds for NAA38 Gene

No Compound Related Data Available

Transcripts for NAA38 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NAA38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP3: -

Relevant External Links for NAA38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAA38 Gene

mRNA expression in normal human tissues for NAA38 Gene

Protein differential expression in normal tissues from HIPED for NAA38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Nasal epithelium (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA38 Gene

genes like me logo Genes that share expression patterns with NAA38: view

Protein tissue co-expression partners for NAA38 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA38 Gene

Orthologs for NAA38 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA38 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAA38 35
  • 88.69 (n)
  • 88.24 (a)
LSMD1 36
  • 77 (a)
(Canis familiaris)
Mammalia NAA38 35
  • 87.67 (n)
  • 85.55 (a)
LSMD1 36
  • 40 (a)
(Mus musculus)
Mammalia Naa38 35
  • 83.33 (n)
  • 94 (a)
Naa38 16
Lsmd1 36
  • 76 (a)
(Pan troglodytes)
Mammalia NAA38 35
  • 99.42 (n)
  • 98.27 (a)
LSMD1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Naa38 35
  • 83.67 (n)
  • 94 (a)
(Monodelphis domestica)
Mammalia LSMD1 36
  • 71 (a)
(Gallus gallus)
Aves LSMD1 35
  • 76.07 (n)
  • 75.64 (a)
LSMD1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia LSMD1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia naa38 35
  • 71.87 (n)
  • 75 (a)
Str.17236 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6876 35
(Danio rerio)
Actinopterygii naa38 35
  • 66.27 (n)
  • 78.57 (a)
wufj33f12 35
lsmd1 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31950 36
  • 33 (a)
Species with no ortholog for NAA38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAA38 Gene

Gene Tree for NAA38 (if available)
Gene Tree for NAA38 (if available)

Paralogs for NAA38 Gene

(4) SIMAP similar genes for NAA38 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NAA38: view

No data available for Paralogs for NAA38 Gene

Variants for NAA38 Gene

Sequence variations from dbSNP and Humsavar for NAA38 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1064035 -- 7,877,429(-) ATGTA(A/G)AGACA intron-variant
rs1565816 -- 7,864,170(-) TTCTT(A/C)CAGCC intron-variant
rs2029739 -- 7,880,680(+) GCTCA(A/G)CTTAC intron-variant
rs4265881 -- 7,871,441(+) TACTA(C/T)TTTTG intron-variant
rs4290529 -- 7,864,413(+) ACTCC(C/T)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA38 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv889088 CNV Gain 21882294
nsv5920 CNV Insertion 18451855

Variation tolerance for NAA38 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NAA38 Gene

Disorders for NAA38 Gene

Relevant External Links for NAA38

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAA38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA38 Gene

Publications for NAA38 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 67
  2. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim K.K. … Arnesen T. (Mol. Cell. Biol. 2009) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Embryonic growth-associated protein is one subunit of a novel N- terminal acetyltransferase complex essential for embryonic vascular development. (PMID: 16484612) Wenzlau J.M. … Weiser-Evans M.C.M. (Circ. Res. 2006) 3

Products for NAA38 Gene

Sources for NAA38 Gene