NAA38 Gene
protein-coding GIFtS: 53
GCID: GC07P117824
|
|
N(alpha)-acetyltransferase 38, NatC auxiliary subunit(Previous names: LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)...)
(Previous symbol: LSM8)
| |
Aliases
for NAA38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N(Alpha)-Acetyltransferase 38, NatC Auxiliary Subunit1 2 | | LSM8 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1 | | LSM81 2 3 | | LSM8 Homolog, U6 Small Nuclear RNA Associated2 | | U6 SnRNA-Associated Sm-Like Protein LSm82 3 | | MAK31-Like Protein2 | | YJR022W1 | | N-Alpha-Acetyltransferase 38, NatC Auxiliary Subunit2 |
Export aliases for NAA38 gene to outside databasesPrevious GC identifer: GC07P112190 |
Summaries
for NAA38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAA38:
This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape,made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form aheteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNAin the nucleus. (provided by RefSeq, Jan 2010)
UniProtKB/Swiss-Prot: NAA38_HUMAN, O95777Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome
Gene Wiki entry for NAA38 (LSM8)
|
Genomic Views
for NAA38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NAA38
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAA38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.1-q31.3 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q31.1-q31.3NAA38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P117824: view genomic region
(about GC identifiers)
Start:
|
117,824,086 bp from pter |
End:
|
117,844,093 bp from pter |
Size:
|
20,008 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 117,219,509-117,239,504 |
|
Proteins
for NAA38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAA38_HUMAN, O95777 (See
protein sequence)Recommended Name: N-alpha-acetyltransferase 38, NatC auxiliary subunit Size: 96 amino acids; 10403 Da
Subunit: LSm subunits form a heteromer with a doughnut shape
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for NAA38: NX_O95777
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95777
NAA38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057284.1
ENSEMBL proteins: ENSP00000249299 ENSP00000395263 ENSP00000403811 ENSP00000408267
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- | | GO:0030529 | ribonucleoprotein complex |
IEA | -- |
NAA38 for ontologies About GeneDecksing
NAA38 Antibody Products:
Assay Products for NAA38: |
Protein
Domains /
Families
for NAA38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAA38 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95777ProtoNet protein and cluster: O95777 2 Blocks protein families: IPB001163 Small nuclear ribonucleoprotein (Sm protein) IPB010920 Like-Sm ribonucleoprotein-related
UniProtKB/Swiss-Prot: NAA38_HUMAN, O95777Similarity: Belongs to the snRNP Sm proteins family |
Function
for NAA38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAA38_HUMAN, O95777Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA38 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NAA38 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NAA38:
|
Pathways & Interactions
for NAA38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for NAA38):
NAA38 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA38
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/88 Interacting proteins for NAA38 (O957771, 2, 3 ENSP000002492994) via UniProtKB, MINT, STRING, and/or I2D (see all 88)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| LSM2 | Q9Y3331, 2, 3, ENSP000003648134 | EBI-347779,EBI-347416 MINT-62688 MINT-62590 MINT-62764 MINT-8336199 I2D:
score=5 STRING: ENSP00000364813 | | LSM3 | P623101, 2, 3, ENSP000003021604 | EBI-347779,EBI-348239 MINT-8336243 I2D:
score=3 STRING: ENSP00000302160 | | LSM4 | Q9Y4Z01, 3, ENSP000002528164 | EBI-347779,EBI-372521 I2D:
score=3 STRING: ENSP00000252816 | | DBF4 | Q9UBU73, ENSP000002657284 | I2D:
score=4 STRING: ENSP00000265728 | | FAM63A | Q8N5J23, ENSP000003548144 | I2D:
score=4 STRING: ENSP00000354814 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000398 | mRNA splicing, via spliceosome |
NAS | -- |
NAA38 for ontologies About GeneDecksing
|
Drugs & Compounds
for NAA38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAA38
Search CenterWatch for drugs/clinical trials and news about NAA38
|
Transcripts
for NAA38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAA38 gene: NM_016200.4 Unigene Cluster for NAA38: N(alpha)-acetyltransferase 38, NatC auxiliary subunit Hs.655046 [show with all ESTs]Unigene Representative Sequence: NM_0162004 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000249299(uc003vjg.3) ENST00000424702 ENST00000422760 ENST00000411938
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA38 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for NAA38 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA38 |
Additional cDNA sequence: AF182294.1 AK311936.1 BC002742.2 BC022440.1 BX537999.1 15 DOTS entries: DT.115713 DT.92009455 DT.110277 DT.100662478 DT.80100375 DT.95274095 DT.91658409 DT.309200 DT.110278 DT.121108915 DT.100667712 DT.75162217 DT.102834265 DT.91762921 DT.120805871 24/189 AceView cDNA sequences (see all 189): AA554299 N32524 Z44780 AL600056 AA578593 BC053644 AI358735 AA992175 AI933638 AW078874 BM023159 Z40586 AA742187 AA885244 AI243658 BF436500 BM546875 BQ009177 AA953298 BX503520 Z44888 AA580457 BU601738 BM721745
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NAA38 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for NAA38
|
Expression
for NAA38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAA38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACGAGTATT
About this image
See NAA38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAA38
SOURCE GeneReport for Unigene cluster: Hs.655046
SABiosciences Custom PCR Arrays for NAA38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA38
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA38 |
Orthologs
for NAA38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAA38 gene from 7/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NAA381 |
N(alpha)-acetyltransferase 38, NatC auxiliary subunit |
85.76(n)
98.96(a) |
|
417765 XM_416009.3 XP_416009.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BG360358.12 |
-- |
84.04(n) |
|
BG360358.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.170552 |
Transcribed sequence with strong similarity to protein more |
74.44(n) |
|
BM026429.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG20211 |
CG2021 |
60.99(n)
69.15(a) |
|
38229 NM_139403.1 NP_647660.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
lsm-81 |
Protein LSM-8 |
54.58(n)
60.44(a) |
|
177393 NM_068563.3 NP_500964.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G657001 |
U6 snRNA-associated Sm-like protein LSm8 |
61.05(n)
62.11(a) |
|
842881 NM_001036161.1 NP_001031238.1 |
rice
(Oryza sativa) |
Liliopsida |
Os05g05949001 |
hypothetical protein |
58.33(n)
63.04(a) |
|
4339810 NM_001063045.1 NP_001056510.1 |
ENSEMBL Gene Tree for NAA38 (if available)
TreeFam Gene Tree for NAA38 (if available) |
Paralogs
for NAA38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAA38 gene
- LSM12
6 SIMAP similar genes for NAA38 using alignment to 4 protein entries: NAA38_HUMAN (see all proteins):LSM8 SNRPG LSM1 SNRPB SNRPN LSM7
NAA38 for paralogs About GeneDecksing
|
Genomic Variants
for NAA38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAA38 (117824086 - 117844093 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAA38: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAA38 |
|
Disorders
/ Diseases
for NAA38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAA38 for disorders About GeneDecksing
OMIM gene information: 607288
OMIM disorders: --
4  diseases for NAA38: About MalaCardsretinitis pigmentosa retinitis hypoxia malaria
Export disorders for NAA38 gene to outside databases
|
Publications
for NAA38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAA38 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with NAA38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
- A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PubMed id 10523320)1, 2, 3 Achsel T....Luhrmann R. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Nuclear LSm8 affects number of cytoplasmic processing bodies via controlling cellular distribution of Like-Sm proteins. (PubMed id 22875987)1 Novotny I....Stanek D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for NAA38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAA38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAA38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAA38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAA38 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAA38 gene:
Search GeneIP for patents involving NAA38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAA38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | NAA38 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA38 |
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