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Aliases for NAA38 Gene

Aliases for NAA38 Gene

  • N(Alpha)-Acetyltransferase 38, NatC Auxiliary Subunit 2 3 5
  • Phosphonoformate Immuno-Associated Protein 2 3 4
  • LSM Domain-Containing Protein 1 3 4
  • LSM Domain Containing 1 2 3
  • PFAAP2 3 4
  • LSMD1 3 4
  • N-Alpha-Acetyltransferase 38, NatC Auxiliary Subunit 3
  • MAK31 4

External Ids for NAA38 Gene

Previous HGNC Symbols for NAA38 Gene

  • LSMD1

Previous GeneCards Identifiers for NAA38 Gene

  • GC07P117824
  • GC07P112190
  • GC17M007763

Summaries for NAA38 Gene

GeneCards Summary for NAA38 Gene

NAA38 (N(Alpha)-Acetyltransferase 38, NatC Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network.

UniProtKB/Swiss-Prot for NAA38 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.

Additional gene information for NAA38 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA38 Gene

Genomics for NAA38 Gene

Regulatory Elements for NAA38 Gene

Enhancers for NAA38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H008055 1.3 Ensembl ENCODE 15.5 -171.6 -171629 2.6 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ATF7 LOC107985075 NAA38 GUCY2D ALOX12B KCNAB3 TRAPPC1 CNTROB SCARNA21 CHD3 CYB5D1
GH17H007833 1.9 FANTOM5 ENCODE dbSUPER 8.3 +45.6 45554 12.5 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC DVL2 PFAS CTC1 WRAP53 POLR2A CNTROB SNORD10 ENSG00000265749 NLGN2 KDM6B
GH17H007989 1.3 Ensembl ENCODE 11.2 -104.9 -104855 1.7 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 BRCA1 ZNF2 GLIS2 ELK1 KCNAB3 ALOX15B CNTROB TRAPPC1 SCARNA21 CHD3 NAA38 TMEM88 CYB5D1 LOC284023
GH17H007914 1.1 ENCODE 11.5 -30.7 -30658 2.9 PKNOX1 ARNT SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 ZNF207 SP3 CNTROB POLR2A WRAP53 DVL2 ENSG00000265749 CTC1 PFAS KCNAB3 NAA38 CYB5D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA38 on UCSC Golden Path with GeneCards custom track

Promoters for NAA38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090915 -717 4401 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 SP3 SP5

Genomic Locations for NAA38 Gene

Genomic Locations for NAA38 Gene
28,599 bases
Minus strand

Genomic View for NAA38 Gene

Genes around NAA38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA38 Gene

Proteins for NAA38 Gene

  • Protein details for NAA38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-alpha-acetyltransferase 38, NatC auxiliary subunit
    Protein Accession:
    Secondary Accessions:
    • Q8N4M0

    Protein attributes for NAA38 Gene

    125 amino acids
    Molecular mass:
    13514 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

    Alternative splice isoforms for NAA38 Gene


neXtProt entry for NAA38 Gene

Post-translational modifications for NAA38 Gene

  • Ubiquitination at posLast=5151 and Lys86
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAA38 Gene

Domains & Families for NAA38 Gene

Gene Families for NAA38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NAA38 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the snRNP Sm proteins family.
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with NAA38: view

Function for NAA38 Gene

Molecular function for NAA38 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.

Phenotypes From GWAS Catalog for NAA38 Gene

Gene Ontology (GO) - Molecular Function for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NAA38: view
genes like me logo Genes that share phenotypes with NAA38: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA38 Gene

Localization for NAA38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA38 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA38 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19398576
GO:0005737 cytoplasm IDA,IEA 19398576
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IEA,IDA 19398576
genes like me logo Genes that share ontologies with NAA38: view

Pathways & Interactions for NAA38 Gene

genes like me logo Genes that share pathways with NAA38: view

Gene Ontology (GO) - Biological Process for NAA38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IMP 19398576
genes like me logo Genes that share ontologies with NAA38: view

No data available for SIGNOR curated interactions for NAA38 Gene

Drugs & Compounds for NAA38 Gene

No Compound Related Data Available

Transcripts for NAA38 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA38 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP3: -

Relevant External Links for NAA38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAA38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA38 Gene

Protein differential expression in normal tissues from HIPED for NAA38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Nasal epithelium (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA38 Gene

Protein tissue co-expression partners for NAA38 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAA38 Gene:


Evidence on tissue expression from TISSUES for NAA38 Gene

  • Pancreas(4.3)
  • Liver(4.2)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with NAA38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA38 Gene

Orthologs for NAA38 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAA38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAA38 33
  • 99.42 (n)
LSMD1 34
  • 98 (a)
(Bos Taurus)
Mammalia NAA38 33
  • 88.69 (n)
LSMD1 34
  • 77 (a)
(Canis familiaris)
Mammalia NAA38 33
  • 87.67 (n)
LSMD1 34
  • 40 (a)
(Rattus norvegicus)
Mammalia Naa38 33
  • 83.67 (n)
(Mus musculus)
Mammalia Naa38 33 16
  • 83.33 (n)
Lsmd1 34
  • 76 (a)
(Monodelphis domestica)
Mammalia LSMD1 34
  • 71 (a)
(Gallus gallus)
Aves LSMD1 33 34
  • 76.07 (n)
(Anolis carolinensis)
Reptilia LSMD1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia naa38 33
  • 71.87 (n)
Str.17236 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6876 33
(Danio rerio)
Actinopterygii naa38 33
  • 66.27 (n)
lsmd1 34
  • 64 (a)
wufj33f12 33
fruit fly
(Drosophila melanogaster)
Insecta CG31950 34
  • 33 (a)
Species where no ortholog for NAA38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAA38 Gene

Gene Tree for NAA38 (if available)
Gene Tree for NAA38 (if available)

Paralogs for NAA38 Gene

(4) SIMAP similar genes for NAA38 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NAA38: view

No data available for Paralogs for NAA38 Gene

Variants for NAA38 Gene

Sequence variations from dbSNP and Humsavar for NAA38 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000065053 -- 7,864,545(+) TCCTG(C/T)CTAGG intron-variant, downstream-variant-500B
rs1000378794 -- 7,856,253(+) GACCT(C/G)AGAGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000406116 -- 7,875,996(+) TGAAT(A/G)ATATT intron-variant
rs1000481168 -- 7,880,669(+) TGTGC(A/G)TGTAA intron-variant
rs1000570951 -- 7,869,044(+) GTTGT(A/G)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA38 Gene

Variant ID Type Subtype PubMed ID
nsv833351 CNV loss 17160897
nsv1070804 CNV deletion 25765185
dgv510n67 CNV gain 20364138

Variation tolerance for NAA38 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA38 Gene

Disorders for NAA38 Gene

Relevant External Links for NAA38

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAA38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA38 Gene

Publications for NAA38 Gene

  1. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim KK … Arnesen T (Molecular and cellular biology 2009) 2 3 4 60
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 60
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for NAA38 Gene

Sources for NAA38 Gene

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