Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NAA35 Gene

Aliases for NAA35 Gene

  • N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit 2 3 5
  • Embryonic Growth-Associated Protein Homolog 3 4
  • Protein MAK10 Homolog 3 4
  • MAK10 3 4
  • EGAP 3 4
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit (S. Cerevisiae) 2
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit 3
  • N-Alpha-Acetyltransferase 35, NatC Auxiliary Subunit 3
  • Corneal Wound Healing-Related Protein 3
  • BA379P1.1 3
  • MAK10P 3

External Ids for NAA35 Gene

Previous HGNC Symbols for NAA35 Gene

  • MAK10

Previous GeneCards Identifiers for NAA35 Gene

  • GC09P088556
  • GC09P058381

Summaries for NAA35 Gene

GeneCards Summary for NAA35 Gene

NAA35 (N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network.

UniProtKB/Swiss-Prot for NAA35 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Additional gene information for NAA35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA35 Gene

Genomics for NAA35 Gene

Regulatory Elements for NAA35 Gene

Enhancers for NAA35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H086731 1.5 Ensembl ENCODE dbSUPER 29.4 +791.3 791339 2 FEZF1 BRCA1 ZNF2 KLF7 FOS SP3 YY2 REST TSHZ1 ZNF488 NAA35 GAS1RR LOC389765 LOC100130049 GAS1 GC09M086730 LOC105376124
GH09H084949 0.8 dbSUPER 41.2 -990.0 -990031 3 ZFP64 ZNF140 ZNF266 ZNF697 ZNF791 ZNF316 ZNF138 RBAK GLI2 ZNF547 NAA35 HNRNPK LOC389765 ENSG00000235298 GC09P085030 GC09P084671
GH09H086348 1.2 Ensembl ENCODE 11.6 +407.5 407534 1 FOXA2 SIN3A ZNF121 GLIS2 ATF7 FOS ZNF202 ZHX2 TSHZ1 ZNF518A C9orf153 NAA35 GAS1RR ZCCHC6 GC09M086340
GH09H086854 1.1 Ensembl ENCODE 11.8 +914.5 914483 2 PKNOX1 FOXA2 INSM2 FEZF1 BMI1 RAD21 ZNF366 ZSCAN5C SCRT2 RCOR1 NAA35 PIR61502 GC09M086730
GH09H086793 0.8 Ensembl ENCODE 9.7 +854.6 854589 3 PRDM6 POLR2A RCOR1 ZNF112 LOC100130049 GAS1RR NAA35 GC09M086730 PIR61502
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA35 on UCSC Golden Path with GeneCards custom track

Promoters for NAA35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237015 158 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 SP5

Genomic Location for NAA35 Gene

Chromosome:
9
Start:
85,941,142 bp from pter
End:
86,025,462 bp from pter
Size:
84,321 bases
Orientation:
Plus strand

Genomic View for NAA35 Gene

Genes around NAA35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA35 Gene

Proteins for NAA35 Gene

  • Protein details for NAA35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZE5-NAA35_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Protein Accession:
    Q5VZE5
    Secondary Accessions:
    • Q5VZE6
    • Q9H631
    • Q9H703

    Protein attributes for NAA35 Gene

    Size:
    725 amino acids
    Molecular mass:
    83639 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
    SequenceCaution:
    • Sequence=BAB15097.1; Type=Frameshift; Positions=518; Evidence={ECO:0000305}; Sequence=BAB15435.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA35 Gene

Post-translational modifications for NAA35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA35 Gene

No data available for DME Specific Peptides for NAA35 Gene

Domains & Families for NAA35 Gene

Gene Families for NAA35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAA35 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VZE5

UniProtKB/Swiss-Prot:

NAA35_HUMAN :
  • Belongs to the MAK10 family.
Family:
  • Belongs to the MAK10 family.
genes like me logo Genes that share domains with NAA35: view

Function for NAA35 Gene

Molecular function for NAA35 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Gene Ontology (GO) - Molecular Function for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA --
GO:0005515 protein binding IPI 19398576
genes like me logo Genes that share ontologies with NAA35: view

Phenotypes for NAA35 Gene

genes like me logo Genes that share phenotypes with NAA35: view

Animal Model Products

CRISPR Products

miRNA for NAA35 Gene

miRTarBase miRNAs that target NAA35

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAA35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA35 Gene

Localization for NAA35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA35 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA35 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IDA 19398576
genes like me logo Genes that share ontologies with NAA35: view

Pathways & Interactions for NAA35 Gene

genes like me logo Genes that share pathways with NAA35: view

Gene Ontology (GO) - Biological Process for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IBA --
GO:0043066 negative regulation of apoptotic process IMP 19398576
GO:0048659 smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with NAA35: view

No data available for SIGNOR curated interactions for NAA35 Gene

Drugs & Compounds for NAA35 Gene

No Compound Related Data Available

Transcripts for NAA35 Gene

Unigene Clusters for NAA35 Gene

N(alpha)-acetyltransferase 35, NatC auxiliary subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAA35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NAA35 Gene

No ASD Table

Relevant External Links for NAA35 Gene

GeneLoc Exon Structure for
NAA35
ECgene alternative splicing isoforms for
NAA35

Expression for NAA35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA35 Gene

Protein differential expression in normal tissues from HIPED for NAA35 Gene

This gene is overexpressed in Breast (32.3), Urine (9.1), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA35 Gene



NURSA nuclear receptor signaling pathways regulating expression of NAA35 Gene:

NAA35

SOURCE GeneReport for Unigene cluster for NAA35 Gene:

Hs.436098

Evidence on tissue expression from TISSUES for NAA35 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with NAA35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA35 Gene

Orthologs for NAA35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA35 33 34
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia NAA35 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA35 33 34
  • 95.26 (n)
dog
(Canis familiaris)
Mammalia NAA35 33 34
  • 94.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA35 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa35 33 16 34
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Naa35 33
  • 88.23 (n)
chicken
(Gallus gallus)
Aves NAA35 33 34
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia NAA35 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa35 33
  • 79.59 (n)
Str.16347 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19076 33
zebrafish
(Danio rerio)
Actinopterygii naa35 33 34
  • 75.51 (n)
wufb21g10 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005863 33
  • 51.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4065 33 34
  • 50.07 (n)
worm
(Caenorhabditis elegans)
Secernentea T23B12.4 33 34
  • 44.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK10 36
thale cress
(Arabidopsis thaliana)
eudicotyledons MAK10 33
  • 42.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10400 33
Species where no ortholog for NAA35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA35 Gene

ENSEMBL:
Gene Tree for NAA35 (if available)
TreeFam:
Gene Tree for NAA35 (if available)

Paralogs for NAA35 Gene

No data available for Paralogs for NAA35 Gene

Variants for NAA35 Gene

Sequence variations from dbSNP and Humsavar for NAA35 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000000904 -- 85,953,061(+) CAAAA(A/G)AATTA intron-variant
rs1000043012 -- 85,988,092(+) ACACA(C/T)GCACA intron-variant
rs1000136120 -- 85,988,430(+) AGGAA(A/G)GCAGT intron-variant
rs1000140533 -- 86,006,565(+) GATTT(A/C)GTTTT intron-variant
rs1000146855 -- 86,015,579(+) TAATT(C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA35 Gene

Variant ID Type Subtype PubMed ID
nsv475991 CNV novel sequence insertion 20440878
nsv519890 CNV loss 19592680
nsv831646 CNV loss 17160897

Variation tolerance for NAA35 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA35 Gene

Human Gene Mutation Database (HGMD)
NAA35
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA35 Gene

Disorders for NAA35 Gene

Relevant External Links for NAA35

Genetic Association Database (GAD)
NAA35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA35

No disorders were found for NAA35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA35 Gene

Publications for NAA35 Gene

  1. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim KK … Arnesen T (Molecular and cellular biology 2009) 2 3 4 60
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for NAA35 Gene

Sources for NAA35 Gene

Content
Loading form....