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Aliases for NAA35 Gene

Aliases for NAA35 Gene

  • N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit 2 3 5
  • Embryonic Growth-Associated Protein Homolog 3 4
  • Protein MAK10 Homolog 3 4
  • MAK10 3 4
  • EGAP 3 4
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit (S. Cerevisiae) 2
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit 3
  • N-Alpha-Acetyltransferase 35, NatC Auxiliary Subunit 3
  • Corneal Wound Healing-Related Protein 3
  • BA379P1.1 3
  • MAK10P 3

External Ids for NAA35 Gene

Previous HGNC Symbols for NAA35 Gene

  • MAK10

Previous GeneCards Identifiers for NAA35 Gene

  • GC09P088556
  • GC09P058381

Summaries for NAA35 Gene

GeneCards Summary for NAA35 Gene

NAA35 (N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Retrograde transport at the Trans-Golgi-Network.

UniProtKB/Swiss-Prot for NAA35 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA35 Gene

Genomics for NAA35 Gene

Regulatory Elements for NAA35 Gene

Enhancers for NAA35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G085878 0.7 ENCODE 10.8 -61.9 -61898 2.4 CTCF PKNOX1 KLF1 ARNT ZIC2 BCL11B PRDM6 ZNF316 CTBP1 GLIS1 NAA35 ENSG00000230303 PHBP7 PIR57070
GH09G085819 0.6 Ensembl 11.5 -121.8 -121842 0.2 CTCF ZNF654 TRIM22 REST RAD21 JUND SMC3 FOS NAA35 LOC389765 GC09P085847
GH09G085859 0.5 ENCODE 10.8 -80.9 -80892 0.6 SMARCC1 JUND PRDM10 TCF7L2 NAA35 AGTPBP1 PIR57070 PHBP7
GH09G085897 0.4 ENCODE 12.1 -43.1 -43142 0.2 SPI1 NAA35 PHBP7 PIR57070
GH09G085984 0.3 FANTOM5 11 +42.9 42904 0.0 NAA35 GC09P085989
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA35 on UCSC Golden Path with GeneCards custom track

Promoters for NAA35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237015 158 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF207 ZNF143

Genomic Location for NAA35 Gene

Chromosome:
9
Start:
85,941,142 bp from pter
End:
86,025,462 bp from pter
Size:
84,321 bases
Orientation:
Plus strand

Genomic View for NAA35 Gene

Genes around NAA35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA35 Gene

Proteins for NAA35 Gene

  • Protein details for NAA35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZE5-NAA35_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Protein Accession:
    Q5VZE5
    Secondary Accessions:
    • Q5VZE6
    • Q9H631
    • Q9H703

    Protein attributes for NAA35 Gene

    Size:
    725 amino acids
    Molecular mass:
    83639 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
    SequenceCaution:
    • Sequence=BAB15097.1; Type=Frameshift; Positions=518; Evidence={ECO:0000305}; Sequence=BAB15435.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA35 Gene

Post-translational modifications for NAA35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA35 Gene

No data available for DME Specific Peptides for NAA35 Gene

Domains & Families for NAA35 Gene

Gene Families for NAA35 Gene

Protein Domains for NAA35 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VZE5

UniProtKB/Swiss-Prot:

NAA35_HUMAN :
  • Belongs to the MAK10 family.
Family:
  • Belongs to the MAK10 family.
genes like me logo Genes that share domains with NAA35: view

Function for NAA35 Gene

Molecular function for NAA35 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Gene Ontology (GO) - Molecular Function for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA --
GO:0005515 protein binding IPI 19398576
genes like me logo Genes that share ontologies with NAA35: view

Phenotypes for NAA35 Gene

genes like me logo Genes that share phenotypes with NAA35: view

Animal Model Products

CRISPR Products

miRNA for NAA35 Gene

miRTarBase miRNAs that target NAA35

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA35 Gene

Localization for NAA35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA35 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA35 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IDA 19398576
genes like me logo Genes that share ontologies with NAA35: view

Pathways & Interactions for NAA35 Gene

genes like me logo Genes that share pathways with NAA35: view

Gene Ontology (GO) - Biological Process for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IBA --
GO:0043066 negative regulation of apoptotic process IMP 19398576
GO:0048659 smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with NAA35: view

No data available for SIGNOR curated interactions for NAA35 Gene

Transcripts for NAA35 Gene

Unigene Clusters for NAA35 Gene

N(alpha)-acetyltransferase 35, NatC auxiliary subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA35 Gene

No ASD Table

Relevant External Links for NAA35 Gene

GeneLoc Exon Structure for
NAA35
ECgene alternative splicing isoforms for
NAA35

Expression for NAA35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA35 Gene

Protein differential expression in normal tissues from HIPED for NAA35 Gene

This gene is overexpressed in Breast (32.3), Urine (9.1), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA35 Gene



NURSA nuclear receptor signaling pathways regulating expression of NAA35 Gene:

NAA35

SOURCE GeneReport for Unigene cluster for NAA35 Gene:

Hs.436098

Evidence on tissue expression from TISSUES for NAA35 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with NAA35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA35 Gene

Orthologs for NAA35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA35 34 35
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia NAA35 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA35 34 35
  • 95.26 (n)
dog
(Canis familiaris)
Mammalia NAA35 34 35
  • 94.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA35 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa35 34 16 35
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Naa35 34
  • 88.23 (n)
chicken
(Gallus gallus)
Aves NAA35 34 35
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia NAA35 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa35 34
  • 79.59 (n)
Str.16347 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19076 34
zebrafish
(Danio rerio)
Actinopterygii naa35 34 35
  • 75.51 (n)
wufb21g10 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005863 34
  • 51.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4065 34 35
  • 50.07 (n)
worm
(Caenorhabditis elegans)
Secernentea T23B12.4 34 35
  • 44.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK10 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MAK10 34
  • 42.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10400 34
Species where no ortholog for NAA35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA35 Gene

ENSEMBL:
Gene Tree for NAA35 (if available)
TreeFam:
Gene Tree for NAA35 (if available)

Paralogs for NAA35 Gene

No data available for Paralogs for NAA35 Gene

Variants for NAA35 Gene

Sequence variations from dbSNP and Humsavar for NAA35 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000000904 -- 85,953,061(+) CAAAA(A/G)AATTA intron-variant
rs1000043012 -- 85,988,092(+) ACACA(C/T)GCACA intron-variant
rs1000136120 -- 85,988,430(+) AGGAA(A/G)GCAGT intron-variant
rs1000140533 -- 86,006,565(+) GATTT(A/C)GTTTT intron-variant
rs1000146855 -- 86,015,579(+) TAATT(C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA35 Gene

Variant ID Type Subtype PubMed ID
nsv475991 CNV novel sequence insertion 20440878
nsv519890 CNV loss 19592680
nsv831646 CNV loss 17160897

Variation tolerance for NAA35 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA35 Gene

Human Gene Mutation Database (HGMD)
NAA35
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA35 Gene

Disorders for NAA35 Gene

Relevant External Links for NAA35

Genetic Association Database (GAD)
NAA35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA35

No disorders were found for NAA35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA35 Gene

Publications for NAA35 Gene

  1. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim K.K. … Arnesen T. (Mol. Cell. Biol. 2009) 2 3 4 64
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for NAA35 Gene

Sources for NAA35 Gene

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