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Aliases for NAA35 Gene

Aliases for NAA35 Gene

  • N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit 2 3
  • Embryonic Growth-Associated Protein Homolog 3 4
  • Protein MAK10 Homolog 3 4
  • MAK10 3 4
  • EGAP 3 4
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit (S. Cerevisiae) 2
  • MAK10 Homolog, Amino-Acid N-Acetyltransferase Subunit 3
  • Corneal Wound Healing-Related Protein 3
  • BA379P1.1 3
  • MAK10P 3

External Ids for NAA35 Gene

Previous HGNC Symbols for NAA35 Gene

  • MAK10

Previous GeneCards Identifiers for NAA35 Gene

  • GC09P088556
  • GC09P058381

Summaries for NAA35 Gene

GeneCards Summary for NAA35 Gene

NAA35 (N(Alpha)-Acetyltransferase 35, NatC Auxiliary Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAA35 Gene

  • Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA35 Gene

Genomics for NAA35 Gene

Genomic Location for NAA35 Gene

Chromosome:
9
Start:
85,941,142 bp from pter
End:
86,025,462 bp from pter
Size:
84,321 bases
Orientation:
Plus strand

Genomic View for NAA35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA35 Gene

No data available for Regulatory Elements for NAA35 Gene

Proteins for NAA35 Gene

  • Protein details for NAA35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZE5-NAA35_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Protein Accession:
    Q5VZE5
    Secondary Accessions:
    • Q5VZE6
    • Q9H631
    • Q9H703

    Protein attributes for NAA35 Gene

    Size:
    725 amino acids
    Molecular mass:
    83639 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
    SequenceCaution:
    • Sequence=BAB15097.1; Type=Frameshift; Positions=518; Evidence={ECO:0000305}; Sequence=BAB15435.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA35 Gene

Proteomics data for NAA35 Gene at MOPED

Post-translational modifications for NAA35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA35 Gene

Domains & Families for NAA35 Gene

Gene Families for NAA35 Gene

Protein Domains for NAA35 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VZE5

UniProtKB/Swiss-Prot:

NAA35_HUMAN :
  • Belongs to the MAK10 family.
Family:
  • Belongs to the MAK10 family.
genes like me logo Genes that share domains with NAA35: view

Function for NAA35 Gene

Molecular function for NAA35 Gene

UniProtKB/Swiss-Prot Function:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Gene Ontology (GO) - Molecular Function for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19398576
genes like me logo Genes that share ontologies with NAA35: view

Phenotypes for NAA35 Gene

GenomeRNAi human phenotypes for NAA35:
genes like me logo Genes that share phenotypes with NAA35: view

Animal Model Products

CRISPR Products

miRNA for NAA35 Gene

miRTarBase miRNAs that target NAA35

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAA35

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA35 Gene

Localization for NAA35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA35 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA35 Gene COMPARTMENTS Subcellular localization image for NAA35 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IDA 19398576
genes like me logo Genes that share ontologies with NAA35: view

Pathways & Interactions for NAA35 Gene

SuperPathways for NAA35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IMP 19398576
GO:0048659 smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with NAA35: view

No data available for Pathways by source and SIGNOR curated interactions for NAA35 Gene

Drugs & Compounds for NAA35 Gene

No Compound Related Data Available

Transcripts for NAA35 Gene

Unigene Clusters for NAA35 Gene

N(alpha)-acetyltransferase 35, NatC auxiliary subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAA35

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA35 Gene

No ASD Table

Relevant External Links for NAA35 Gene

GeneLoc Exon Structure for
NAA35
ECgene alternative splicing isoforms for
NAA35

Expression for NAA35 Gene

mRNA expression in normal human tissues for NAA35 Gene

Protein differential expression in normal tissues from HIPED for NAA35 Gene

This gene is overexpressed in Breast (32.3), Urine (9.1), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA35 Gene



SOURCE GeneReport for Unigene cluster for NAA35 Gene Hs.436098

genes like me logo Genes that share expression patterns with NAA35: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NAA35 Gene

Orthologs for NAA35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAA35 35
  • 95.26 (n)
  • 99.17 (a)
NAA35 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA35 35
  • 94.57 (n)
  • 99.31 (a)
NAA35 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa35 35
  • 88.92 (n)
  • 97.38 (a)
Naa35 16
Naa35 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAA35 35
  • 99.82 (n)
  • 100 (a)
NAA35 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa35 35
  • 88.23 (n)
  • 96.14 (a)
oppossum
(Monodelphis domestica)
Mammalia NAA35 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAA35 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAA35 35
  • 84.6 (n)
  • 96.69 (a)
NAA35 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA35 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa35 35
  • 79.59 (n)
  • 91.31 (a)
Str.16347 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19076 35
zebrafish
(Danio rerio)
Actinopterygii naa35 35
  • 75.51 (n)
  • 85.64 (a)
wufb21g10 35
naa35 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005863 35
  • 51.41 (n)
  • 46.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4065 35
  • 50.07 (n)
  • 42.22 (a)
CG4065 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T23B12.4 35
  • 44.93 (n)
  • 30.45 (a)
T23B12.4 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MAK10 35
  • 42.72 (n)
  • 28.02 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10400 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for NAA35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA35 Gene

ENSEMBL:
Gene Tree for NAA35 (if available)
TreeFam:
Gene Tree for NAA35 (if available)

Paralogs for NAA35 Gene

No data available for Paralogs for NAA35 Gene

Variants for NAA35 Gene

Sequence variations from dbSNP and Humsavar for NAA35 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7450 -- 86,021,972(+) CTGGG(A/G)AGGTG utr-variant-3-prime
rs15898 -- 86,022,055(-) TCCAT(A/C)TCACT utr-variant-3-prime
rs511395 -- 85,947,477(-) AACAC(A/G)GAAAA intron-variant
rs954124 -- 85,948,149(+) TATCT(A/G)TGGAC intron-variant
rs997265 -- 85,996,363(-) TCAAC(G/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA35 Gene

Variant ID Type Subtype PubMed ID
nsv831646 CNV Loss 17160897
nsv519890 CNV Loss 19592680

Variation tolerance for NAA35 Gene

Residual Variation Intolerance Score: 36.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA35 Gene

HapMap Linkage Disequilibrium report
NAA35
Human Gene Mutation Database (HGMD)
NAA35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA35 Gene

Disorders for NAA35 Gene

Relevant External Links for NAA35

Genetic Association Database (GAD)
NAA35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA35
genes like me logo Genes that share disorders with NAA35: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA35 Gene

Publications for NAA35 Gene

  1. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim K.K. … Arnesen T. (Mol. Cell. Biol. 2009) 2 67
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for NAA35 Gene

Sources for NAA35 Gene

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