NAA30 Gene
protein-coding GIFtS: 44
GCID: GC14P057857
|
|
N(alpha)-acetyltransferase 30, NatC catalytic subunit(Previous names: chromosome 14 open reading frame 35, N-acetyltransferase...)
(Previous symbols: C14orf35, NAT12)
| |
Aliases
for NAA30 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N(Alpha)-Acetyltransferase 30, NatC Catalytic Subunit1 2 | | N-Acetyltransferase MAK3 Homolog2 3 | | C14orf351 2 3 | | FLJ353551 | | MAK31 2 3 | | Chromosome 14 Open Reading Frame 351 | | NAT121 2 3 | | N-Alpha-Acetyltransferase 302 | | Mak3p1 2 | | N-Alpha-Acetyltransferase 30, NatC Catalytic Subunit2 | | N-Acetyltransferase 12 (GCN5-Related, Putative)1 2 | | Putative N-Acetyltransferase2 | | N-Acetyltransferase 121 3 | | EC 2.3.1.883 | | NatC Catalytic Subunit2 3 | | |
Export aliases for NAA30 gene to outside databasesPrevious GC identifer: GC14P038022 |
Summaries
for NAA30 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NAA30_HUMAN, Q147X3Function: Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of theN-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomallocalization and function of ARL8B
|
Genomic Views
for NAA30 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NAA30
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAA30
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA30 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.3 Ensembl cytogenetic band: 14q22.3 HGNC cytogenetic band: 14q22.2NAA30 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P057857: view genomic region
(about GC identifiers)
Start:
|
57,857,262 bp from pter |
End:
|
57,882,635 bp from pter |
Size:
|
25,374 bases |
Orientation:
|
plus strand |
|
Proteins
for NAA30 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAA30_HUMAN, Q147X3 (See
protein sequence)Recommended Name: N-alpha-acetyltransferase 30 Size: 362 amino acids; 39320 Da
Subunit: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, LSMD1 and NAA30
Subcellular location: Cytoplasm
Secondary accessions: Q0IIN2Alternative splicing: 2 isoforms: Q147X3-1 Q147X3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NAA30: NX_Q147X3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q147X3
NAA30 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001011713.2
ENSEMBL proteins: ENSP00000450939 ENSP00000452521 ENSP00000451255 ENSP00000298406
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
NAA30 for ontologies About GeneDecksing
NAA30 Antibody Products:
Assay Products for NAA30: |
Protein
Domains /
Families
for NAA30 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAA30 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q147X3ProtoNet protein and cluster: Q147X3 UniProtKB/Swiss-Prot: NAA30_HUMAN, Q147X3Similarity: Belongs to the acetyltransferase family. MAK3 subfamilySimilarity: Contains 1 N-acetyltransferase domain |
Function
for NAA30 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAA30_HUMAN, Q147X3Function: Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of theN-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomallocalization and function of ARL8BCatalytic activity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoAEnzyme Number (IUBMB): EC 2.3.1.881
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA30 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA30 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NAA30 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA30 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA30 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004596 | peptide alpha-N-acetyltransferase activity |
IEA | -- | | GO:0008080 | N-acetyltransferase activity |
-- | -- |
NAA30 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Naa30 (no phenotypes)
NAA30 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NAA30 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Biological oxidations | |
1  BioSystems Pathway for NAA30
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA30
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for NAA30 (ENSP000002984064) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for NAA30 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAA30
Search CenterWatch for drugs/clinical trials and news about NAA30
|
Transcripts
for NAA30 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAA30 gene: NM_001011713.2 Unigene Cluster for NAA30: N(alpha)-acetyltransferase 30, NatC catalytic subunit Hs.165465 [show with all ESTs]Unigene Representative Sequence: NM_0010117134 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555166 ENST00000556492(uc001xcx.4 uc010trk.2 uc010aow.3)
ENST00000554703 ENST00000298406
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA30 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA30 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAA30 (NM_001011713) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAA30 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA30 |
Additional cDNA sequence: AK024885.1 AK025749.1 AK092674.1 AK296372.1 AK304257.1 AK307348.1 BC048983.1 BC118589.1 BC122557.1 BX648700.1 7 DOTS entries: DT.415321 DT.441829 DT.102824364 DT.100754625 DT.95106614 DT.97823552 DT.120753996 24/156 AceView cDNA sequences (see all 156): BM873588 AA541417 BM313443 AI298002 AA351407 AI753449 R42930 AI452950 W60557 CA437004 N46008 BQ186228 CA941313 BI964191 AA442141 CB242587 AI393257 BE327045 CA941607 AI803224 H67235 BQ959365 AI687432 AA608632
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NAA30 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for NAA30
|
Expression
for NAA30 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAA30 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATCACTAA
About this image
See NAA30 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAA30
SOURCE GeneReport for Unigene cluster: Hs.165465
SABiosciences Custom PCR Arrays for NAA30
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA30
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA30 |
Orthologs
for NAA30 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAA30 gene from 10/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Naa301 , 5 |
N(alpha)-acetyltransferase 30, NatC catalytic subunit1, 5 |
89.23(n)1
88.2(a)1 |
|
14 (25.42 cM)5
706461 NM_001081430.11 NP_001074899.11
491722265 |
chicken
(Gallus gallus) |
Aves |
NAA301 |
N(alpha)-acetyltransferase 30, NatC catalytic subunit |
79.66(n)
80.51(a) |
|
423547 XM_421440.3 XP_421440.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NAA306 |
-- |
64(a) |
1 ↔ 1 |
GL343325.1(829576-852840) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.102902 |
Xenopus laevis transcribed sequence with weak similarity more |
86.88(n) |
|
CA973347.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.195572 |
Transcribed sequence with weak similarity to protein more |
77.5(n) |
|
AL911505.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG323196CG114126 |
-- |
42(a)32(a) |
possible ortholog1 ↔ 1 |
3L(1470850-1472060) X(1236118-1238803) |
worm
(Caenorhabditis elegans) |
Secernentea |
B0238.106 |
Protein B0238.10 |
36(a) |
1 ↔ 1 |
V(5274058-5275546) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MAK3(YPR051W)4
MAK31 |
Catalytic subunit of N-terminal acetyltransferase of more4
Mak3p1 |
58.33(n)1
53.57(a)1 |
|
16(664960-665490)4
8561631, 4 NP_015376.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATMAK36 |
peptide alpha-N-acetyltransferase |
46(a) |
1 ↔ 1 |
2(15978512-15980749) |
rice
(Oryza sativa) |
Liliopsida |
-- |
acetyltransferase, GNAT family, putative, expresse... |
45(a) |
1 ↔ 1 |
11(18609967-18613000) |
ENSEMBL Gene Tree for NAA30 (if available)
TreeFam Gene Tree for NAA30 (if available) |
Paralogs
for NAA30 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NAA30 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAA30 (57857262 - 57882635 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAA30: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAA30 |
|
Disorders
/ Diseases
for NAA30 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAA30 for disorders About GeneDecksing
1  disease for NAA30: About MalaCardsmalaria
Export disorders for NAA30 gene to outside databases
|
Publications
for NAA30 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAA30 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NAA30) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PubMed id 19398576)2 Starheim K.K.... Arnesen T. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NAA30 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAA30 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAA30 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAA30 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAA30 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAA30 gene:
Search GeneIP for patents involving NAA30
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAA30 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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