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Aliases for NAA30 Gene

Aliases for NAA30 Gene

  • N(Alpha)-Acetyltransferase 30, NatC Catalytic Subunit 2 3 5
  • N-Acetyltransferase 12 (GCN5-Related, Putative) 2 3
  • N-Acetyltransferase MAK3 Homolog 3 4
  • N-Acetyltransferase 12 2 4
  • NatC Catalytic Subunit 3 4
  • C14orf35 3 4
  • NAT12 3 4
  • MAK3 3 4
  • Chromosome 14 Open Reading Frame 35 2
  • N-Alpha-Acetyltransferase 30 3
  • Putative N-Acetyltransferase 3
  • EC 2.3.1.88 4
  • NAT12P 3
  • Mak3p 3

External Ids for NAA30 Gene

Previous HGNC Symbols for NAA30 Gene

  • C14orf35
  • NAT12

Previous GeneCards Identifiers for NAA30 Gene

  • GC14P057857
  • GC14P038022

Summaries for NAA30 Gene

GeneCards Summary for NAA30 Gene

NAA30 (N(Alpha)-Acetyltransferase 30, NatC Catalytic Subunit) is a Protein Coding gene. Diseases associated with NAA30 include Eastern Equine Encephalitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Vesicle-mediated transport. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA30 Gene

  • Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA30 Gene

Genomics for NAA30 Gene

Regulatory Elements for NAA30 Gene

Enhancers for NAA30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F057389 0.2 ENCODE 18.2 +0.6 570 3.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 GLIS2 SP3 YY2 SP5 NAA30 GC14P057427
GH14F057264 0.4 ENCODE 17.8 -123.1 -123050 5.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 NAA30 ENSG00000259969 AP5M1 ENSG00000258592
GH14F057361 0.4 ENCODE 10.8 -28.2 -28174 1.7 JUN MAFK NR2F2 NAA30 ENSG00000259008
GH14F057261 0.2 Ensembl 9.7 -128.7 -128744 0.4 HLF ADNP HNF4G ZNF644 YY1 NAA30 AP5M1 ENSG00000258592
GH14F057486 0.4 FANTOM5 6 +96.4 96410 0.4 CTCF ZNF654 SCRT2 SMC3 TRIM22 RAD21 MIXL1 NAA30 C14orf105 GC14P057427
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAA30 on UCSC Golden Path with GeneCards custom track

Promoters for NAA30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001789604 -844 201 TFDP1 PKNOX1 SCRT2 CEBPA CEBPB MLLT1 CEBPG
ENSR00000418469 1256 3601 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 GLIS2 SP3 YY2 SP5

Genomic Location for NAA30 Gene

Chromosome:
14
Start:
57,390,544 bp from pter
End:
57,415,917 bp from pter
Size:
25,374 bases
Orientation:
Plus strand

Genomic View for NAA30 Gene

Genes around NAA30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA30 Gene

Proteins for NAA30 Gene

  • Protein details for NAA30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q147X3-NAA30_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 30
    Protein Accession:
    Q147X3
    Secondary Accessions:
    • Q0IIN2

    Protein attributes for NAA30 Gene

    Size:
    362 amino acids
    Molecular mass:
    39320 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

    Alternative splice isoforms for NAA30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA30 Gene

Post-translational modifications for NAA30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA30 Gene

No data available for DME Specific Peptides for NAA30 Gene

Domains & Families for NAA30 Gene

Protein Domains for NAA30 Gene

Suggested Antigen Peptide Sequences for NAA30 Gene

Graphical View of Domain Structure for InterPro Entry

Q147X3

UniProtKB/Swiss-Prot:

NAA30_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. MAK3 subfamily.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. MAK3 subfamily.
genes like me logo Genes that share domains with NAA30: view

Function for NAA30 Gene

Molecular function for NAA30 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.

Enzyme Numbers (IUBMB) for NAA30 Gene

Gene Ontology (GO) - Molecular Function for NAA30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 19398576
GO:0005515 protein binding IPI 19398576
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAA30: view

Phenotypes for NAA30 Gene

genes like me logo Genes that share phenotypes with NAA30: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA30

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA30 Gene

Localization for NAA30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA30 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA30 Gene COMPARTMENTS Subcellular localization image for NAA30 gene
Compartment Confidence
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAA30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19398576
GO:0005844 colocalizes_with polysome IDA 19398576
GO:0031417 NatC complex IDA 19398576
genes like me logo Genes that share ontologies with NAA30: view

Pathways & Interactions for NAA30 Gene

genes like me logo Genes that share pathways with NAA30: view

Gene Ontology (GO) - Biological Process for NAA30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017196 N-terminal peptidyl-methionine acetylation IDA 19398576
genes like me logo Genes that share ontologies with NAA30: view

No data available for SIGNOR curated interactions for NAA30 Gene

Drugs & Compounds for NAA30 Gene

(1) Drugs for NAA30 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for NAA30 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with NAA30: view

Transcripts for NAA30 Gene

Unigene Clusters for NAA30 Gene

N(alpha)-acetyltransferase 30, NatC catalytic subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA30 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - - -
SP3: -
SP4: - - - -

Relevant External Links for NAA30 Gene

GeneLoc Exon Structure for
NAA30
ECgene alternative splicing isoforms for
NAA30

Expression for NAA30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA30 Gene

Protein differential expression in normal tissues from HIPED for NAA30 Gene

This gene is overexpressed in Breast (19.2) and Fetal Brain (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA30 Gene



Protein tissue co-expression partners for NAA30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA30 Gene:

NAA30

SOURCE GeneReport for Unigene cluster for NAA30 Gene:

Hs.165465
genes like me logo Genes that share expression patterns with NAA30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA30 Gene

Orthologs for NAA30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA30 34 35
  • 99.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA30 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA30 34 35
  • 94.83 (n)
cow
(Bos Taurus)
Mammalia NAA30 34 35
  • 93.25 (n)
rat
(Rattus norvegicus)
Mammalia Naa30 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Naa30 34 16 35
  • 87.23 (n)
oppossum
(Monodelphis domestica)
Mammalia NAA30 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAA30 34 35
  • 78.92 (n)
lizard
(Anolis carolinensis)
Reptilia NAA30 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa30 34
  • 77.3 (n)
Str.1080 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10290 34
zebrafish
(Danio rerio)
Actinopterygii naa30 35
  • 50 (a)
OneToOne
Dr.19557 34
fruit fly
(Drosophila melanogaster)
Insecta CG32319 35
  • 43 (a)
OneToMany
CG11412 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0238.10 35
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK3 35 37
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4735 35
  • 25 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.532 34
Species where no ortholog for NAA30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA30 Gene

ENSEMBL:
Gene Tree for NAA30 (if available)
TreeFam:
Gene Tree for NAA30 (if available)

Paralogs for NAA30 Gene

(1) SIMAP similar genes for NAA30 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NAA30: view

No data available for Paralogs for NAA30 Gene

Variants for NAA30 Gene

Sequence variations from dbSNP and Humsavar for NAA30 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1057737 -- 57,393,970(-) GGTTT(C/T)TAATC intron-variant
rs1058010 -- 57,412,161(+) AAACT(A/G)CTTTA utr-variant-3-prime
rs1059481 -- 57,411,516(+) TAGGG(A/G)TGGTT utr-variant-3-prime
rs11158159 -- 57,390,444(+) AGCCC(C/G)CAGGA upstream-variant-2KB
rs111666786 -- 57,397,184(+) ATACT(A/G)CAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA30 Gene

Variant ID Type Subtype PubMed ID
esv2664347 CNV deletion 23128226
esv3634606 CNV loss 21293372
nsv1046422 CNV gain 25217958
nsv832806 CNV loss 17160897

Variation tolerance for NAA30 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA30 Gene

Disorders for NAA30 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAA30 Gene - From: DISEASES

Disorder Aliases PubMed IDs
eastern equine encephalitis
  • eee
- elite association - COSMIC cancer census association via MalaCards
Search NAA30 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAA30

Genetic Association Database (GAD)
NAA30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA30
genes like me logo Genes that share disorders with NAA30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA30 Gene

Publications for NAA30 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 64
  2. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. (PMID: 19398576) Starheim K.K. … Arnesen T. (Mol. Cell. Biol. 2009) 2 3 4 64
  3. Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells. (PMID: 26292663) Mughal A.A. … Stangeland B. (Mol. Cancer 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for NAA30 Gene

Sources for NAA30 Gene

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