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Aliases for NAA25 Gene

Aliases for NAA25 Gene

  • N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit 2 3 5
  • N-Terminal Acetyltransferase B Complex Subunit NAA25 3 4
  • NatB Complex Subunit MDM20 3 4
  • C12orf30 3 4
  • MDM20 3 4
  • NAP1 3 4
  • N-Alpha-Acetyltransferase 25, NatB Auxiliary Subunit 3
  • Mitochondrial Distribution And Morphology Protein 20 4
  • N-Terminal Acetyltransferase B Complex Subunit MDM20 4
  • Mitochondrial Distribution And Morphology 20 3
  • Chromosome 12 Open Reading Frame 30 2
  • P120 4

External Ids for NAA25 Gene

Previous HGNC Symbols for NAA25 Gene

  • C12orf30

Previous GeneCards Identifiers for NAA25 Gene

  • GC12M112464
  • GC12M109477

Summaries for NAA25 Gene

Entrez Gene Summary for NAA25 Gene

  • This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]

GeneCards Summary for NAA25 Gene

NAA25 (N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA25 include N-Terminal Acetyltransferase Deficiency and Rheumatoid Arthritis, Systemic Juvenile.

UniProtKB/Swiss-Prot for NAA25 Gene

  • Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA25 Gene

Genomics for NAA25 Gene

Regulatory Elements for NAA25 Gene

Enhancers for NAA25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F112386 0.6 Ensembl ENCODE 22.7 -278.4 -278379 1.6 HDGF ATF1 ZNF2 ZNF121 ZNF416 ZNF143 KLF7 DEK SP3 REST NAA25 MAPKAPK5 HECTD4 MIR6861 PTPN11
GH12F111150 0.4 Ensembl 20.5 +958.5 958522 0.2 ZNF493 ZFP64 ZNF140 ZNF266 ZNF101 ZFHX2 ZNF354C SCRT2 KLF7 ZNF433 MAPKAPK5 PCNPP1 ADAM1A NAA25 HSPA8P14 ANAPC7 FAM216A CUX2 TRAFD1 GC12M111175
GH12F112106 0.7 ENCODE 14.3 +0.2 225 4.6 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 TMEM116 MAPKAPK5 NAA25 ADAM1A ENSG00000200688
GH12F111971 0.7 ENCODE 13.7 +137.1 137102 0.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 MAPKAPK5 NAA25 TMEM116 ERP29 GC12P111986 ADAM1B
GH12F112407 0.7 ENCODE 13.6 -299.7 -299712 3.0 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 MAPKAPK5 DDX54 ADAM1A NAA25 SLC8B1 TMEM116 PTPN11 MIR6861 HECTD4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAA25 on UCSC Golden Path with GeneCards custom track

Promoters for NAA25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000437207 422 2801 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for NAA25 Gene

Chromosome:
12
Start:
112,026,689 bp from pter
End:
112,109,022 bp from pter
Size:
82,334 bases
Orientation:
Minus strand

Genomic View for NAA25 Gene

Genes around NAA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA25 Gene

Proteins for NAA25 Gene

  • Protein details for NAA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX7-NAA25_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Protein Accession:
    Q14CX7
    Secondary Accessions:
    • A0JLU7
    • Q6MZH1
    • Q7Z4N6
    • Q9H911

    Protein attributes for NAA25 Gene

    Size:
    972 amino acids
    Molecular mass:
    112292 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
    SequenceCaution:
    • Sequence=BAB14432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE46062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA25 Gene

Post-translational modifications for NAA25 Gene

  • Ubiquitination at Lys 742
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA25 Gene

No data available for DME Specific Peptides for NAA25 Gene

Domains & Families for NAA25 Gene

Gene Families for NAA25 Gene

Protein Domains for NAA25 Gene

Suggested Antigen Peptide Sequences for NAA25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CX7

UniProtKB/Swiss-Prot:

NAA25_HUMAN :
  • Belongs to the MDM20/NAA25 family.
  • Contains 4 TPR repeats.
Family:
  • Belongs to the MDM20/NAA25 family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with NAA25: view

Function for NAA25 Gene

Molecular function for NAA25 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

Gene Ontology (GO) - Molecular Function for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IBA --
genes like me logo Genes that share ontologies with NAA25: view
genes like me logo Genes that share phenotypes with NAA25: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA25 Gene

Localization for NAA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA25 Gene COMPARTMENTS Subcellular localization image for NAA25 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0031416 NatB complex IBA --
genes like me logo Genes that share ontologies with NAA25: view

Pathways & Interactions for NAA25 Gene

SuperPathways for NAA25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017196 N-terminal peptidyl-methionine acetylation IBA --
genes like me logo Genes that share ontologies with NAA25: view

No data available for Pathways by source and SIGNOR curated interactions for NAA25 Gene

Transcripts for NAA25 Gene

Unigene Clusters for NAA25 Gene

N(alpha)-acetyltransferase 25, NatB auxiliary subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6: - -
SP7:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NAA25 Gene

GeneLoc Exon Structure for
NAA25
ECgene alternative splicing isoforms for
NAA25

Expression for NAA25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA25 Gene

Protein differential expression in normal tissues from HIPED for NAA25 Gene

This gene is overexpressed in Lymph node (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA25 Gene



Protein tissue co-expression partners for NAA25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA25 Gene:

NAA25

SOURCE GeneReport for Unigene cluster for NAA25 Gene:

Hs.530941
genes like me logo Genes that share expression patterns with NAA25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA25 Gene

Orthologs for NAA25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA25 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia NAA25 34 35
  • 94.55 (n)
dog
(Canis familiaris)
Mammalia NAA25 34 35
  • 94.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Naa25 34 16 35
  • 87.11 (n)
rat
(Rattus norvegicus)
Mammalia Naa25 34
  • 86.62 (n)
oppossum
(Monodelphis domestica)
Mammalia NAA25 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAA25 34 35
  • 79.39 (n)
lizard
(Anolis carolinensis)
Reptilia NAA25 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa25 34
  • 72.23 (n)
Str.1475 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7595 34
zebrafish
(Danio rerio)
Actinopterygii naa25 34 35
  • 66.77 (n)
Dr.14297 34
fruit fly
(Drosophila melanogaster)
Insecta psidin 34 35
  • 47.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta NAA25_ANOGA 34
  • 46.85 (n)
worm
(Caenorhabditis elegans)
Secernentea cra-1 34 35
  • 43.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDM20 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa25 34
  • 40.82 (n)
Species where no ortholog for NAA25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA25 Gene

ENSEMBL:
Gene Tree for NAA25 (if available)
TreeFam:
Gene Tree for NAA25 (if available)

Paralogs for NAA25 Gene

(3) SIMAP similar genes for NAA25 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NAA25: view

No data available for Paralogs for NAA25 Gene

Variants for NAA25 Gene

Sequence variations from dbSNP and Humsavar for NAA25 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035872 A breast cancer sample
rs10219716 -- 112,065,670(+) AAAAA(A/T)AAATA intron-variant
rs10431388 -- 112,026,827(+) AATAA(C/T)AAGCC downstream-variant-500B, utr-variant-3-prime
rs10437843 -- 112,105,196(+) ccgcc(G/T)gcagt intron-variant
rs10459143 -- 112,068,743(+) AGTAC(C/T)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA25 Gene

Variant ID Type Subtype PubMed ID
nsv483114 CNV gain 15286789
nsv52789 CNV deletion 16902084

Variation tolerance for NAA25 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA25 Gene

Disorders for NAA25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAA25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
n-terminal acetyltransferase deficiency
  • ogden syndrome
rheumatoid arthritis, systemic juvenile
  • juvenile rheumatoid arthritis
- elite association - COSMIC cancer census association via MalaCards
Search NAA25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAA25

Genetic Association Database (GAD)
NAA25
Human Genome Epidemiology (HuGE) Navigator
NAA25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA25
genes like me logo Genes that share disorders with NAA25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA25 Gene

Publications for NAA25 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 64
  2. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim K.K. … Lillehaug J.R. (Biochem. J. 2008) 2 3 4 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 64
  4. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PMID: 21437268) McKay J.D. … Brennan P. (PLoS Genet. 2011) 3 46 64
  5. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PMID: 18978792) Cooper J.D. … Todd J.A. (Nat. Genet. 2008) 3 46 64

Products for NAA25 Gene

Sources for NAA25 Gene

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