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Aliases for NAA25 Gene

Aliases for NAA25 Gene

  • N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit 2 3 5
  • N-Terminal Acetyltransferase B Complex Subunit NAA25 3 4
  • NatB Complex Subunit MDM20 3 4
  • C12orf30 3 4
  • MDM20 3 4
  • NAP1 3 4
  • Mitochondrial Distribution And Morphology Protein 20 4
  • N-Terminal Acetyltransferase B Complex Subunit MDM20 4
  • Mitochondrial Distribution And Morphology 20 3
  • Chromosome 12 Open Reading Frame 30 2
  • P120 4

External Ids for NAA25 Gene

Previous HGNC Symbols for NAA25 Gene

  • C12orf30

Previous GeneCards Identifiers for NAA25 Gene

  • GC12M112464
  • GC12M109477

Summaries for NAA25 Gene

Entrez Gene Summary for NAA25 Gene

  • This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]

GeneCards Summary for NAA25 Gene

NAA25 (N(Alpha)-Acetyltransferase 25, NatB Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA25 include N-Terminal Acetyltransferase Deficiency.

UniProtKB/Swiss-Prot for NAA25 Gene

  • Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA25 Gene

Genomics for NAA25 Gene

Regulatory Elements for NAA25 Gene

Enhancers for NAA25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAA25 on UCSC Golden Path with GeneCards custom track

Promoters for NAA25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAA25 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA25 Gene

Chromosome:
12
Start:
112,026,689 bp from pter
End:
112,109,022 bp from pter
Size:
82,334 bases
Orientation:
Minus strand

Genomic View for NAA25 Gene

Genes around NAA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA25 Gene

Proteins for NAA25 Gene

  • Protein details for NAA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX7-NAA25_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Protein Accession:
    Q14CX7
    Secondary Accessions:
    • A0JLU7
    • Q6MZH1
    • Q7Z4N6
    • Q9H911

    Protein attributes for NAA25 Gene

    Size:
    972 amino acids
    Molecular mass:
    112292 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
    SequenceCaution:
    • Sequence=BAB14432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE46062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA25 Gene

Proteomics data for NAA25 Gene at MOPED

Post-translational modifications for NAA25 Gene

  • Ubiquitination at Lys 742
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA25 Gene

No data available for DME Specific Peptides for NAA25 Gene

Domains & Families for NAA25 Gene

Gene Families for NAA25 Gene

Protein Domains for NAA25 Gene

Suggested Antigen Peptide Sequences for NAA25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CX7

UniProtKB/Swiss-Prot:

NAA25_HUMAN :
  • Belongs to the MDM20/NAA25 family.
  • Contains 4 TPR repeats.
Family:
  • Belongs to the MDM20/NAA25 family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with NAA25: view

Function for NAA25 Gene

Molecular function for NAA25 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.
genes like me logo Genes that share phenotypes with NAA25: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA25 Gene

Localization for NAA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA25 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA25 Gene COMPARTMENTS Subcellular localization image for NAA25 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NAA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NAA25: view

Pathways & Interactions for NAA25 Gene

SuperPathways for NAA25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAA25 Gene

Drugs & Compounds for NAA25 Gene

No Compound Related Data Available

Transcripts for NAA25 Gene

Unigene Clusters for NAA25 Gene

N(alpha)-acetyltransferase 25, NatB auxiliary subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA25 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6: - -
SP7:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NAA25 Gene

GeneLoc Exon Structure for
NAA25
ECgene alternative splicing isoforms for
NAA25

Expression for NAA25 Gene

mRNA expression in normal human tissues for NAA25 Gene

Protein differential expression in normal tissues from HIPED for NAA25 Gene

This gene is overexpressed in Lymph node (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA25 Gene



SOURCE GeneReport for Unigene cluster for NAA25 Gene Hs.530941

genes like me logo Genes that share expression patterns with NAA25: view

Protein tissue co-expression partners for NAA25 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA25 Gene

Orthologs for NAA25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAA25 35
  • 94.55 (n)
  • 96.81 (a)
NAA25 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA25 35
  • 94.17 (n)
  • 96.3 (a)
NAA25 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa25 35
  • 87.11 (n)
  • 92.9 (a)
Naa25 16
Naa25 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAA25 35
  • 99.73 (n)
  • 99.49 (a)
NAA25 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa25 35
  • 86.62 (n)
  • 92.38 (a)
oppossum
(Monodelphis domestica)
Mammalia NAA25 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NAA25 35
  • 79.39 (n)
  • 85.08 (a)
NAA25 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA25 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa25 35
  • 72.23 (n)
  • 76.83 (a)
Str.1475 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7595 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14297 35
naa25 35
  • 66.77 (n)
  • 71.09 (a)
naa25 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NAA25_ANOGA 35
  • 46.85 (n)
  • 37.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta psidin 35
  • 47.28 (n)
  • 37.95 (a)
psidin 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cra-1 35
  • 43.8 (n)
  • 29.91 (a)
cra-1 36
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDM20 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa25 35
  • 40.82 (n)
  • 27.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for NAA25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA25 Gene

ENSEMBL:
Gene Tree for NAA25 (if available)
TreeFam:
Gene Tree for NAA25 (if available)

Paralogs for NAA25 Gene

(3) SIMAP similar genes for NAA25 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NAA25: view

No data available for Paralogs for NAA25 Gene

Variants for NAA25 Gene

Sequence variations from dbSNP and Humsavar for NAA25 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_033156 -
VAR_035872 A breast cancer sample
rs16941860 - 112,061,260(+) TGGTA(C/G)AAGCC nc-transcript-variant, reference, missense
rs12298022 - 112,033,286(+) AATTA(A/G/T)ATGTG reference, missense
rs1973825 -- 112,042,516(-) aaaaa(A/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA25 Gene

Variant ID Type Subtype PubMed ID
nsv52789 CNV Loss 16902084
nsv483114 CNV Gain 15286789

Variation tolerance for NAA25 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NAA25 Gene

Disorders for NAA25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAA25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
n-terminal acetyltransferase deficiency
  • ogden syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NAA25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAA25

Genetic Association Database (GAD)
NAA25
Human Genome Epidemiology (HuGE) Navigator
NAA25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA25
genes like me logo Genes that share disorders with NAA25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA25 Gene

Publications for NAA25 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 67
  2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3
  3. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim K.K. … Lillehaug J.R. (Biochem. J. 2008) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NAA25 Gene

Sources for NAA25 Gene

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